CN108125857B - It is a kind of quickly to defoam bacteriostatic hand sanitizer and preparation method thereof - Google Patents
It is a kind of quickly to defoam bacteriostatic hand sanitizer and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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Abstract
The invention belongs to daily necessities fields, more particularly to a kind of quickly defoaming bacteriostatic hand sanitizer and preparation method thereof, it is made of following components and its weight percent: laureth sodium sulfovinate 3-7%, lauroylamidopropyl betaine 6-12%, sodium lauroyl sarcosine 2-5%, Sha graceful 1-3% of ancient India, skin is releived composition 5-12%, Monoolein 0.3-0.8%, silicone emulsion 0.02-0.05%, citric acid 0.1-0.2%, parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.5%, salicylic acid 0.1-0.5%, essence 0.1-0.3%, the deionized water of 75~80% ethanol solutions 0.3~1% and surplus.Hand cleanser of the present invention has the advantages that blistering is fast, defoaming is fast, and it is 6min that the residual foam extinction time of hand washing sink is most short after washing one's hands, and the hand cleanser is small to the irritation of sensitive, can be used for a long time.
Description
Technical field
The invention belongs to daily necessities fields, and in particular to a kind of quickly to defoam bacteriostatic hand sanitizer and preparation method thereof.
Background technique
Surfactant is most important cleansing in cleaning products, and general surfactant usually has a water-wet side
(being attracted on hydrone) and a hydrophobic side (while it repels water in conjunction with the grease in dirt).When these have parent simultaneously
When water end (W.E.) and the surfactant of hydrophobic side are dissolved in water, which imparts the performances that product can remove dirt.
With the raising of people's quality of life and the concern to health, foam type bacteriostatic hand sanitizer is increasingly by consumer
Favor.The richness of foam would generally be added largely when foam type bacteriostatic hand sanitizer in the prior art is washed one's hands to pursue
Anionic surfactant, the most commonly used is AES, general dosage is 10% or more.It is this living containing high level anionic surface
The hand cleanser of property agent, can generate foam abundant when in use.But its there are a serious drawback, most consumers
It is reflected in after having used this hand cleanser, since a large amount of foam of generation can not dissipate in a short time, needs with a large amount of
Water rinses remaining foam, is on the one hand serious waste for water resource, and on the other hand, the foam washed out by water is not due to
Have and be effectively destroyed, after repeatedly washing one's hands, may result in these foams and spilt into hand washing sink by the way that sewer pipe is counter, influenced
Beautiful and health.
And aiming at the problem that foam can not be deteriorated in time, it attempts that defoaming agent is added to be feasible, but joined and disappear
Infusion can reduce lather quickness when washing one's hands and foaming abundancy degree when washing one's hands again.Therefore, how guarantee wash one's hands when
The technical issues of residual foam rapid dispersion capable of being made to be current urgent need to resolve again while lather quickness and foaming abundancy are spent.
In addition, AES is common surfactant, with good blistering and effect of deoiling, if but for directly connecing
When touching skin product, when hand cleanser especially containing high level AES, the sebum of skin surface is easily taken away, is caused quick
Perceptual skin person generates uncomfortable and aggravates stimulation, therefore, needs the small hand cleanser of the stimulation of a kind of pair of sensitive subjects skin at present.
Summary of the invention
The present invention is intended to provide a kind of quickly defoaming bacteriostatic hand sanitizer and preparation method thereof, the hand cleanser is fast with blistering,
Foaming abundancy, and the residual foam after washing one's hands is easy to dissipate, while sensibility skin is stimulated small, it is answered suitable for promoting on a large scale
With.
In order to achieve the above object, the invention adopts the following technical scheme: a kind of quickly defoam bacteriostatic hand sanitizer, by following
Component and its weight percent composition: laureth sodium sulfovinate 3-7%, lauroylamidopropyl betaine 6-12%, laurel
Acylsarcosine sodium 2-5%, Sha graceful 1-3% of ancient India, skin are releived composition 5-12%, Monoolein 0.3-0.8%, emulsification silicon
Oily 0.02-0.05%, citric acid 0.1-0.2%, parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-
0.5%, the deionization of salicylic acid 0.1-0.5%, essence 0.1-0.3%, 75~80% ethanol solutions 0.3~1% and surplus
Water.
Further, the hand cleanser is made of following components and its weight percent: laureth sodium sulfovinate 5-
7%, lauroylamidopropyl betaine 6-10%, sodium lauroyl sarcosine 3-5%, Sha graceful 1-3% of ancient India, skin are releived composition 5-
10%, Monoolein 0.3-0.6%, silicone emulsion 0.02-0.05%, citric acid 0.1-0.2%, parachlorometaxylenol
0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.4%, salicylic acid 0.1-0.3%, essence 0.1-0.3%, 75~80% second
The deionized water of alcoholic solution 0.5~1% and surplus.
Further, the hand cleanser is made of following components and its weight percent: laureth sodium sulfovinate
5%, lauroylamidopropyl betaine 9%, sodium lauroyl sarcosine 3%, Sha be of ancient India graceful 2%, skin is releived composition 8%, glycerol
Monoleate 0.6%, silicone emulsion 0.04%, citric acid 0.15%, parachlorometaxylenol 0.2%, coconut oil monoethanol acyl
Amine 0.35%, salicylic acid 0.3%, essence 0.2%, 75~80% ethanol solutions 0.8% and surplus deionized water.
Further, the hand cleanser is made of following components and its weight percent: laureth sodium sulfovinate
5%, lauroylamidopropyl betaine 6%, sodium lauroyl sarcosine 3%, Sha be of ancient India graceful 1%, skin is releived composition 5%, glycerol
Monoleate 0.3%, silicone emulsion 0.02%, citric acid 0.1%, parachlorometaxylenol 0.1%, Coconut Fatty Acid Monoethanolamide
0.2%, the deionized water of salicylic acid 0.1%, essence 0.1%, 75~80% ethanol solutions 0.5% and surplus.
Further, the hand cleanser is made of following components and its weight percent: laureth sodium sulfovinate
7%, lauroylamidopropyl betaine 10%, sodium lauroyl sarcosine 5%, Sha be of ancient India graceful 3%, skin is releived composition 10%, sweet
Oily monoleate 0.6%, silicone emulsion 0.05%, citric acid 0.2%, parachlorometaxylenol 0.3%, coconut oil monoethanol acyl
Amine 0.4%, salicylic acid 0.3%, essence 0.3%, 75~80% ethanol solutions 1% and surplus deionized water.
Further, the skin releive composition be comprising 5~15wt% go chlorophyll green-tea extract, 0.1~
The solution of 1wt% nonpolar amino acid and 5~10wt% Rosmarinus officinalis extract.
Further, the skin releives composition to go to the non-pole of chlorophyll green-tea extract, 0.4wt% comprising 12wt%
The solution of acidic amino acid and 8wt% Rosmarinus officinalis extract.
Further, the nonpolar amino acid is selected from one of leucine, valine and phenylalanine.
Further, the nonpolar amino acid is selected from leucine.
Further, described that chlorophyll green-tea extract is gone to be made by following steps:
S1, it takes fresh green tea to clean, dries in the shade, crush, 60~80% ethanol solution of 2~5 times of green tea total amount amounts is added
It extracts 1~3 time, merges, obtain ethanol extract；
S2, above-mentioned ethanol extract is passed through into D152 resin column, and is washed till flow liquid without muddy with 60~80% ethanol solution
It is turbid, collect flow liquid to get.
Further, institute's Rosmarinus officinalis extract is made by following steps: being taken rosemary blade, is crushed after drying in the shade, fan is added
The repeatedly water of 2~5 times of amounts of fragrant total amount, decoct 1~3 time, filtering, merging filtrate to get.
Correspondingly, the present invention also provides a kind of methods for preparing above-mentioned hand cleanser, comprising the following steps:
Parachlorometaxylenol and salicylic acid first are dissolved with ethanol solution, obtains mixed solution, it is spare；It is added in 1/2 water
Laureth sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, Buddhist Sha be graceful, Monoolein and cream
SiClx oil, stirring is to being completely dissolved；It sequentially adds Coconut Fatty Acid Monoethanolamide, salicylic acid and skin to releive composition, stirring
Uniformly, the water of above-mentioned mixed solution, essence and surplus is then added, stirring is eventually adding lemon acid for adjusting pH, i.e., to dissolving
?.
Further, the pH of the hand cleanser is 4.0-4.6.
Further, the viscosity of the hand cleanser is 1500-3000cps.
At the beginning, the technical thought that inventor provides is with laureth sodium sulfovinate (AES), dodecanamide propyl sweet tea
Dish alkali and sodium lauroyl sarcosine are as surfactant, and wherein laureth sodium sulfovinate is used as primary surfactant
Amount is 10~15%, undertakes main barbotage, and three's compounding can reach higher lather quickness and enough foams
Richness, but there are a serious drawbacks: a large amount of residual foam is difficult to short time dissipation after washing one's hands.Therefore, it invents
People attempts to be added Monoolein and silicone emulsion, test prove the movement be it is feasible, joined defoaming agent and greatly drop
The low stability of residual foam makes remaining foam be easier to dissipate, and residual foam dissipates substantially after 12min, but again
There is a new problem: joined defoaming agent and result in the decline of lather quickness and foaming abundancy degree (initial bubble is high only
For 121mm).And this problem is also that cannot effectively solve the problems, such as always in the art at present, inventor is attempting to solve
Certainly during the above problem, look for another way, joined a kind of cyclic lipopeptide surfactant, Buddhist Sha is graceful, it has unexpectedly been found that, it should
The addition of cyclic lipopeptide surfactant produces following effect: even if joined defoaming agent, the lather quickness and bubble of hand cleanser
The richness of foam remains within ideal level, and the initial height that steeps can reach 195mm, and residual foam extinction time is
6min, especially it is surprising that this effect can also be reached by not needing a large amount of AES (content is 3~7%) is added in hand cleanser
Fruit greatly reduces the dosage of AES, is truly realized that blistering is fast, defoaming also fast effect.
And it be emphasized that the application can obtain said effect, it may be possible to because of the group of surfactant of the present invention
It is different to close type, the general prior art is with anionic surfactant, nonionic surfactant or amphoteric surfactant
One or more of collocation form surfactant system, and what the present inventor took is and above-mentioned entirely different think of
Road, present invention adds cyclic lipopeptide surfactant, exactly because may this difference just achieve it is above-mentioned unexpected
Effect.
Another key point is to joined skin in hand cleanser and releives composition in the present invention, main function be for
Reducing AES when hand cleanser is used for a long time stimulates caused by sensitive.Test proves, using joined skin of the present invention
Releive composition when, smooth feeling and moisture feeling are obvious, and non-stimulated to sensitive skin.
The invention has the following advantages that
1) hand cleanser of the present invention has the advantages that blistering is fast, defoams fast, the residual foam extinction time of hand washing sink after washing one's hands
Most short is 6min, and the residual foam extinction time of commercially available hand cleanser is 23min, and the hand cleanser is to the thorn of sensitive
It is small to swash property, can be used for a long time.
2) present invention is arranged in pairs or groups with laureth sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine 3%
Sha's graceful formation surfactant package of ancient India, is aided with defoaming agent, forms a kind of blistering, defoams fast system, with prior art phase
Than achieving significant progress.
3) it releives composition the present invention also provides a kind of skin, can reduce in hand cleanser AES to sensitive
Stimulation.
Specific embodiment
The specific embodiment of form by the following examples makees further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
Sha's graceful molecular formula of ancient India is C53H93N7O13, is bought in Beijing Geordie Asia Bioisystech Co., Ltd, article No. S3523.
Embodiment 1, the preparation for removing chlorophyll green-tea extract
S1, fresh green tea is taken to clean, shade is dry, crushes, and 75% ethanol solution that 3 times of green tea total amount amounts are added extracts 2 times,
Merge, obtains ethanol extract；
S2, above-mentioned ethanol extract is washed till flow liquid without muddiness by D152 resin column, and with 75% ethanol solution, received
Take flow liquid to get wherein amount of resin and medical fluid ratio are 1:3.
The preparation of embodiment 2, repeatedly fragrant extract
It is crushed after taking rosemary blade, shade dry, the water of 5 times of rosemary total amount amounts is added, decocted 3 times, filtering merges filter
Liquid to get.
The preparation of embodiment 3, green-tea extract
The difference from embodiment 1 is that removing step S2, remaining parameter and operation are as described in Example 1.
Embodiment 4, a kind of bacteriostatic hand sanitizer quickly defoamed
Laureth sodium sulfovinate 5%, lauroylamidopropyl betaine 9%, sodium lauroyl sarcosine 3%, Buddhist Sha are graceful
2%, skin releive composition 8%, Monoolein 0.6%, silicone emulsion 0.04%, citric acid 0.15%, between chlorine two
Cresols 0.2%, Coconut Fatty Acid Monoethanolamide 0.35%, salicylic acid 0.3%, essence 0.2%, 75% ethanol solution 0.8% with
And the deionized water of surplus, the skin releive composition be comprising gone described in 12wt% embodiment 1 chlorophyll green-tea extract,
The aqueous solution of Rosmarinus officinalis extract described in 0.4wt% leucine and 8wt% embodiment 2.
Preparation method:
Parachlorometaxylenol and salicylic acid first are dissolved with ethanol solution, obtains mixed solution, it is spare；It is added in 1/2 water
Laureth sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, Buddhist Sha be graceful, Monoolein and cream
SiClx oil, stirring is to being completely dissolved；It sequentially adds Coconut Fatty Acid Monoethanolamide, salicylic acid and skin to releive composition, stirring
Uniformly, the water of above-mentioned mixed solution, essence and surplus is then added, to dissolving, being eventually adding lemon acid for adjusting pH is for stirring
4.5 to get.
Embodiment 5, a kind of bacteriostatic hand sanitizer quickly defoamed
Laureth sodium sulfovinate 5%, lauroylamidopropyl betaine 6%, sodium lauroyl sarcosine 3%, Buddhist Sha are graceful
1%, skin releive composition 5%, Monoolein 0.3%, silicone emulsion 0.02%, citric acid 0.1%, between diformazan chlorine
Phenol 0.1%, Coconut Fatty Acid Monoethanolamide 0.2%, salicylic acid 0.1%, essence 0.1%, 75~80% ethanol solutions 0.5% with
And the deionized water of surplus；The skin releive composition be comprising gone described in 6wt% embodiment 1 chlorophyll green-tea extract,
The aqueous solution of Rosmarinus officinalis extract described in 0.2wt% valine and 5wt% embodiment 2.
Preparation method reference implementation example 4.
Embodiment 6, a kind of bacteriostatic hand sanitizer quickly defoamed
Laureth sodium sulfovinate 7%, lauroylamidopropyl betaine 10%, sodium lauroyl sarcosine 5%, Buddhist Sha are graceful
3%, skin releive composition 10%, Monoolein 0.6%, silicone emulsion 0.05%, citric acid 0.2%, between chlorine two
Cresols 0.3%, Coconut Fatty Acid Monoethanolamide 0.4%, salicylic acid 0.3%, essence 0.3%, 75~80% ethanol solutions 1% with
And the deionized water of surplus；The skin releive composition be comprising gone described in 15wt% embodiment 1 chlorophyll green-tea extract,
The aqueous solution of Rosmarinus officinalis extract described in 0.4wt% phenylalanine and 10wt% embodiment 2.
Preparation method reference implementation example 4.
Comparative example 1, a kind of bacteriostatic hand sanitizer quickly defoamed
Difference with embodiment 4 is, removes that Buddhist Sha is graceful, remaining parameter and operation are as described in Example 4.
Comparative example 2, a kind of bacteriostatic hand sanitizer quickly defoamed
Difference with embodiment 4 is, graceful, remaining parameter that substitutes Buddhist Sha with cyclic lipopeptide type surfactant surfaction
And operation is as described in Example 4.
Comparative example 3, a kind of bacteriostatic hand sanitizer quickly defoamed
Difference with embodiment 4 is, substitutes laureth sodium sulfovinate with lauryl sodium sulfate, remaining parameter and
Operation is as described in Example 4.
Comparative example 4, a kind of bacteriostatic hand sanitizer quickly defoamed
Difference with embodiment 4 is that the skin releives composition to extract comprising green tea described in 12wt% embodiment 3
The aqueous solution of Rosmarinus officinalis extract described in object, 0.4wt% leucine and 8wt% embodiment 2.
Test example one, foam performance test
1. sample: (droplet dew health is antibacterial for hand cleanser and commercially available hand cleanser prepared by embodiment 4~6 and comparative example 1~3
Hand cleanser).
2.Ross-Miles method measures foaming properties: Example 4~6, comparative example 1~3 and the configuration of commercially available hand cleanser
At the sample solution of 0.02% solubility, take each sample solution of 200ml from high 900mm, internal diameter 2.9mm pore in flow down, pour
With in mutually synthermal and concentration 50ml sample solution, foam height when record has flowed 200ml sample solution is used as tested
The foaming power evaluation index of test, blister 5min after evaluation index of the foam height as foam stability, and record each group steep
Foam completely disappears the time.
3. test result: test result is as shown in table 1:
1 foam performance test result of table
| Classification | Initial bubbles height (mm) | Foam height (mm) after blistering 5min | Residual foam extinction time (min) |
| Droplet dew | 136 | 102 | 23 |
| Embodiment 4 | 195 | 5 | 6 |
| Embodiment 5 | 189 | 5 | 6 |
| Embodiment 6 | 186 | 6 | 6 |
| Comparative example 1 | 127 | 72 | 15 |
| Comparative example 2 | 133 | 60 | 12 |
| Comparative example 3 | 152 | 51 | 10 |
Note: initial bubbles height is bigger, and expression foaming abundancy degree is bigger；Foam height is smaller after blistering 5min, indicates foam
Stability is poor, and antifoaming speed is fast.
As shown in Table 1, compared with commercially available hand cleanser, 4~6 hand cleanser of the embodiment of the present invention has excellent foam performance,
Its initial bubbles height can reach 195mm, and 6min or so residual foam disappears substantially, and commercially available hand cleanser initial bubbles are high
Degree is 136mm, and foam vanishing time needs 23min, and in contrast, hand cleanser of the present invention has reached quick truly
Bubble has both the effect quickly defoamed.
It should be pointed out that the initial bubble of comparative example 1 (it is graceful compared with Example 4, to be added without Buddhist Sha) described hand cleanser is high
34.8% is reduced compared with Example 4, although it is compared with commercially available hand cleanser, foam time is shortened, with implementation
For example 4 compared to 9min is extended, this explanation, Sha's graceful addition of ancient India can significantly improve foaming abundancy degree when washing one's hands, and can also
Enough reduce the stability of residual foam.
The initial bubble Gao Yushi of comparative example 2 (compared with Example 4, substitute Buddhist Sha with the surfaction graceful) hand cleanser
Example 4 is applied compared to reducing 31.7%, foam vanishing time extends 8min, this explanation, not all cyclic lipopeptide surface
Activating agent is suitable for the present invention and washes one's hands liquid system, and compared with surfaction, Sha graceful present invention that is more suitable for of ancient India washes one's hands liquid
System.
The initial bubble of comparative example 3 (compared with Example 4, substitute Buddhist Sha with the lauryl sodium sulfate graceful) hand cleanser is high
22.1% is reduced compared with Example 4, and foam vanishing time extends 4min.
Test example two, using effect test
The evaluation of 2.1 sensory effects
2.1.1 sample: the hand cleanser that the embodiment of the present invention 4~6 and comparative example 4 are prepared.
40 testers are equally divided into 10 groups, give specimen sample at random, it is desirable that tester is daily according to itself
Habit of washing one's hands is washed one's hands, smooth feeling, moisture feeling and the irritation when successively washing one's hands according to 2 evaluation criterion of table evaluation each group sample,
It is finally the scoring of each sample sensory effects with mean values, evaluation result is as shown in table 3.
2 evaluation criterion of table
| Project | 1~3 point | 4~6 points | 7~9 points |
| Smooth feeling | Without smooth feeling | Smooth feeling is general | Smooth feeling is obvious |
| Moisture feeling | Without moisture feeling | Moisture feeling is general | Moisture feeling is obvious |
| Irritation | Stimulation is strong | There are minimal irritations | It is non-stimulated |
3 evaluation result of table
| Group | Smooth feeling | Moisture feeling | Irritation |
| Embodiment 4 | 9.2 | 9.5 | 9.8 |
| Embodiment 5 | 9.0 | 9.3 | 9.6 |
| Embodiment 6 | 8.9 | 9.0 | 9.2 |
| Comparative example 4 | 7.4 | 8.2 | 5.9 |
As shown in Table 3, when 10 groups of subjects are thought using 4~6 hand cleanser of the embodiment of the present invention, smooth feeling, moisture feeling
Obviously, and irritation is small, and comparative example 4 (compared with Example 4, removing chlorophyll green-tea extract with green-tea extract substitution) is washed
Smooth feeling, the moisture feeling of hand liquid decreased significantly than embodiment 4, and 10 groups of subjects think to wash one's hands using comparative example 4
There are slight excitements when liquid.
The evaluation of 2.2 fungistatic effects
1. sample: hand cleanser prepared by embodiment 4~6 and comparative example 1~4.
2. test method: being made staphylococcus aureus, Escherichia coli and Candida albicans according to " disinfection technology standard "
For bacteriostatic test object, experimental concentration is hand cleanser stoste, and action time 1min, experimental temperature is 18-22 DEG C, is calculated antibacterial
Rate (%), test are averaged in triplicate.
3. test result: test result is as shown in table 4:
4 bacteriostatic test test result of table
By table 3,4 it is found that 4~6 hand cleanser of the embodiment of the present invention is to staphylococcus aureus, Escherichia coli and Candida albicans
Bacterium all has preferable fungistatic effect, meets the requirement of antibacterial disinfection.Wherein 4 fungistatic effect of embodiment is best, is of the invention
Most preferred embodiment.Significantly decline it is surprising that the fungistatic effect of comparative example 4 has compared with Example 4, this illustrates this hair
The releive variation of composition component of bright skin will affect the fungistatic effect of hand cleanser.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (8)
1. a kind of quickly defoaming bacteriostatic hand sanitizer, which is characterized in that be made of following components and its weight percent: laruyl alcohol is poly-
Ether sodium sulfovinate 3-7%, lauroylamidopropyl betaine 6-12%, sodium lauroyl sarcosine 2-5%, Sha graceful 1-3% of ancient India, skin
Releive composition 5-12%, Monoolein 0.3-0.8%, silicone emulsion 0.02-0.05%, citric acid 0.1-0.2%, right
Chloxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.5%, salicylic acid 0.1-0.5%, essence 0.1-
0.3%, the deionized water of 75~80% ethanol solutions 0.3~1% and surplus.
2. hand cleanser as described in claim 1, which is characterized in that be made of following components and its weight percent: laruyl alcohol
Polyethers sodium sulfovinate 5-7%, lauroylamidopropyl betaine 6-10%, sodium lauroyl sarcosine 3-5%, Sha graceful 1-3% of ancient India, skin
Skin releive composition 5-10%, Monoolein 0.3-0.6%, silicone emulsion 0.02-0.05%, citric acid 0.1-0.2%,
Parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.4%, salicylic acid 0.1-0.3%, essence 0.1-
0.3%, the deionized water of 75~80% ethanol solutions 0.5~1% and surplus.
3. hand cleanser as described in claim 1, which is characterized in that be made of following components and its weight percent: laruyl alcohol
Group that polyethers sodium sulfovinate 5%, lauroylamidopropyl betaine 9%, sodium lauroyl sarcosine 3%, Sha are of ancient India graceful 2%, skin is releived
Close object 8%, Monoolein 0.6%, silicone emulsion 0.04%, citric acid 0.15%, parachlorometaxylenol 0.2%, coconut palm
Oleic monoethanolamide 0.35%, salicylic acid 0.3%, essence 0.2%, 75~80% ethanol solutions 0.8% and surplus are gone
Ionized water.
4. the hand cleanser as described in claims 1 to 3 is any, which is characterized in that the skin releive composition be comprising 5~
15wt% removes the solution of chlorophyll green-tea extract, 0.1~1wt% nonpolar amino acid and 5~10wt% Rosmarinus officinalis extract.
5. hand cleanser as claimed in claim 4, which is characterized in that the skin releive composition be comprising 12wt% defoliation it is green
The solution of plain green-tea extract, 0.4wt% nonpolar amino acid and 8wt% Rosmarinus officinalis extract.
6. hand cleanser as claimed in claim 5, which is characterized in that the nonpolar amino acid be selected from leucine, valine and
One of phenylalanine.
7. hand cleanser as claimed in claim 4, which is characterized in that described to go chlorophyll green-tea extract by following steps system
:
S1, it takes fresh green tea to clean, dries in the shade, crush, 60~80% ethanol solution that 2~5 times of green tea total amount amounts are added extracts 1
~3 times, merges, obtain ethanol extract；
S2, above-mentioned ethanol extract is washed till flow liquid without muddiness by D152 resin column, and with 60~80% ethanol solution, received
Take flow liquid to get.
8. hand cleanser as claimed in claim 4, which is characterized in that institute's Rosmarinus officinalis extract is made by following steps: fan being taken to change
Spiceleaf piece crushes after drying in the shade, be added 2~5 times of rosemary total amount amount water, decoct 1~3 time, filtering, merging filtrate to get.
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| CN110585099A (en) * | 2019-10-12 | 2019-12-20 | 福建省梦娇兰日用化学品有限公司 | Baby moisturizing and nourishing shower gel prepared by plant chlorophyll centrifugal extraction technology |
| CN111150695A (en) * | 2020-01-14 | 2020-05-15 | 浙江神英科技股份有限公司 | Preparation method of hand sanitizer with super-strong decontamination effect |
| CN112168770A (en) * | 2020-10-08 | 2021-01-05 | 福建省梦娇兰日用化学品有限公司 | Moisturizing and bacteriostatic hand sanitizer containing natural plant extract improved formula for infants |
| CN113083151A (en) * | 2021-03-16 | 2021-07-09 | 华东理工大学 | Synergistic thickening viscoelastic micelle system of sodium surfactin and chlorinated cationic surfactant |
| CN115040427B (en) * | 2022-06-07 | 2024-02-02 | 全芯生物科技(澳门)有限公司 | Hand sanitizer with slow release effect and preparation method thereof |
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| CN106474776A (en) * | 2016-10-18 | 2017-03-08 | 合肥新万成环保科技有限公司 | A kind of can quick hyperbranched polyether modified organic silicon defoamer of froth breaking and preparation method thereof |
| CN106667795B (en) * | 2017-02-06 | 2018-05-08 | 邹伟权 | A kind of soluble cleaning tissue with deep layer cleaning and preparation method thereof |
| CN106974861B (en) * | 2017-04-07 | 2020-01-31 | 深圳微伴生物有限公司 | amino acid soluble facial cleaning paper and preparation method thereof |
| CN107185276A (en) * | 2017-05-25 | 2017-09-22 | 完美（中国）有限公司 | A kind of quick debubbling method of cleaning product |
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