KR102041867B1 - Skin cosmetic composition comprising the extract of Hibiscus Esculentus, Chenopodium quinoa, PunicagranatumL., Perilla frutescens, Chamaecyparis obtusa, Propolis and synthetic peptide - Google Patents

Abstract

The present invention relates to a skin cosmetic composition containing okra, quinoa, pomegranate, perilla, perilla extract, and propolis and synthetic peptides, which are anti-oxidant, anti-inflammatory, skin moisturizer, skin elasticity, wrinkle improvement, anti-aging and whitening It relates to a cosmetic composition having an excellent effect to assist the effect.

Description

Skin cosmetic composition comprising the extract of Hibiscus Esculentus, Chenopodium quinoa, Punicagranatum L., Perilla frutescens, Chamaecyparis obtusa, Propolis and synthetic peptide}

The present invention relates to skin cosmetic compositions containing okra, quinoa, pomegranate, perilla, perilla extract mixtures and propolis and synthetic peptides.

Since the stratum corneum of the skin, which is the outermost layer that distinguishes the human body from the outside, is in direct contact with the outside, it acts as a barrier to prevent invasion of harmful substances or pathogens from the outside and to prevent loss of internal moisture and electrolytes into the body. .

The stratum corneum contains about 10 to 20% of moisture and gives the skin flexibility, elasticity and moisturizing through water retention. In the stratum corneum, lipid components such as free fatty acids, glycerol lipids, ceramides, and natural moisturizing factors (NMFs), which are hydrophilic and hygroscopic substances, play an important role in skin softness and moisture retention (J. Invest. Dermatol. 54, 24--31, 1970)

However, when the water content of the stratum corneum decreases (usually 10% or less), the skin becomes dry and causes direct and indirect causes such as itching, atopic dermatitis, and dermatitis. Therefore, the importance of maintaining a healthy and elastic skin by promoting a sufficient moisture retention of the stratum corneum by providing a barrier to inhibit moisture loss even in a dry environment.

Accordingly, recently, animal moisturizing materials such as snail cream and horse oil cream, which are excellent animal cosmetic materials for moisturizing and skin troubles, have shown sensational interest and sales volume.

However, animal cosmetic materials have poor social awareness of animal raw materials due to diseases such as cow, pig and poultry such as mad cow disease, foot-and-mouth disease and avian influenza, and have exposed many problems to their use due to resistance by animal protection groups. .

Therefore, research on various natural vegetable cosmetic materials has been actively conducted recently. Natural vegetable cosmetic materials are easy to secure the raw materials, high safety, good consumer recognition, and simple separation and purification process has the advantage of lowering the production cost.

Looking at the prior art for the cosmetic material using the natural vegetable raw material, one or two or more selected from the group consisting of calcium, manganese, magnesium and zinc in Korean Patent Publication No. 10-2015-0112617 (October 07, 2015) A mineral component comprising a; And quinoa extracts are known for moisturizing cosmetic compositions.

In addition, Korean Patent Registration No. 10-1490762 (February 02, 2015) is known as an antioxidant cosmetic composition containing an okra polysaccharide extracted from the fruit of mature okra (Hibiscus esculentus) from which the skin is removed as an active ingredient.

In addition, Korean Patent Registration No. 10-1676292 (November 09, 2016) is a pulverized product mixed with 80 to 120 parts by weight of okra and 80 to 120 parts by weight of yam compared to 100 parts by weight of dried kelp and to produce a pulverized product by grinding At least one organic solvent selected from water, alcohol, C1 to C4 alcohol, chloroform, ethyl acetate, diethyl ether, hexane, dihydric alcohol of C2 to C5, and acetone 100 5 to 10 parts by weight of the crushed powder is added to the mixed extract material manufacturing step of preparing a mixed extract material through stirring, and removing the pulverized solid product through filtration by using the filter paper or filter cloth for the prepared mixed extract material. A liquid filtration extract collection step of collecting a liquid filtration extract, concentration of the collected liquid filtration extract under reduced pressure to remove the organic solvent Preparing a concentrated filter extract, the mixed extract manufacturing step of preparing a mixed extract of a solid phase by removing the water and the organic solvent contained in the concentrated filter extract through a vacuum freeze-drying process. 100 to 100 parts by weight of distilled water, 30 to 50 parts by weight of 1,3-butylene glycol and 30 to 50 parts by weight of glycerin (glycerine) to dissolve 1.6 to 20 parts by weight of the mixed extract in a liquid cosmetics There is known a method for producing a cosmetic composition comprising a kelp, okra and yam mixed extract comprising a cosmetic composition completion step of completing the composition.

In addition, Korean Patent Registration No. 10-1574556 (November 30, 2015) is a round hemp, fresh vinegar, okra, and taro extracts of round hemp, fresh vinegar, okra, and taro mixed extracts each having a weight ratio of 2: 1: 1: 2. BACKGROUND ART Cosmetic compositions for moisturizing skin containing 0.005 to 50% by weight based on the total weight of the cosmetic composition are known.

However, the patents use quinoa extract, okra extract alone, or by simply mixing several natural plants, so the antioxidant or anti-inflammatory effect is excellent, but the skin moisturizing, skin elasticity and wrinkle improvement effects are insufficient and satisfactory. There was a problem.

[Patent Document 001] Korea Patent Publication 10-2015-0112617 (October 07, 2015) [Patent Document 002] Korea Patent Registration 10-1490762 (February 02, 2015) [Patent Document 003] Korea Patent Registration 10-1676292 (November 9, 2016) [Patent Document 004] Korea Patent Registration 10-1574556 (November 30, 2015)

In order to solve the above problems, the present invention provides a skin cosmetic composition containing okra, quinoa, pomegranate, perilla, cypress extract mixture and propolis and synthetic peptide to prevent the skin's antioxidant, anti-inflammatory, skin moisturizing, skin elasticity, It is intended to help wrinkle improvement, anti-aging and whitening effects.

In order to solve the above problems, a skin cosmetic composition containing okra, quinoa, pomegranate, perilla, cypress extract mixture, propolis and synthetic peptide is used as a solution to the problem.

The okra extract extracts okra leaves and fruits with an extraction solvent selected from water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform and hexane, and filtered the solution.

The quinoa extract is dried quinoa flowers, leaves, berries and seeds, and then extracted with an extraction solvent selected from water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane, and filtered It is done.

The pomegranate extract is a pomegranate powder: water is mixed in a weight ratio of 1: 2 to 10 and extracted by heating for 1 to 24 hours at 50 ~ 100 ℃ as a means of solving the problem is a solution of the problem.

The perilla extract is the solution of perilla to extract perilla for 72 hours at room temperature with ethanol and then filtered.

The cypress extract is extracted by heating the cypress branches and leaves to 70 ~ 80 ℃ with water and filtered to solve the problem.

The synthetic peptide is selected from the group consisting of Nicotinoyl Dipeptide, Palmitoyl pentapeptide, Copper tripeptide, Acetyl Hexa peptide, Tripeptide, Palrmitoyl Oligopeptide, HumanOligopeptide, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Tetrapeptide, Pentapeptide, Hexapeptide, Opepeptide .

The skin cosmetic composition is a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, oil, pack, soap, shampoo, cleansing Solution to the problem consists of any one selected from the group consisting of foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder and eye shadow.

Skin cosmetic composition containing okra, quinoa, pomegranate, perilla, perilla extract and propolis and synthetic peptide of the present invention is effective in anti-oxidation, anti-inflammatory, skin moisturizing, skin elasticity, wrinkle improvement, anti-aging and whitening effect of skin There is an excellent effect that helps.

1 is a view showing the cytotoxicity evaluation of the cosmetic composition of the present invention
2 is a diagram showing the stability evaluation of the cosmetic composition of the present invention

The present invention is characterized by a skin cosmetic composition containing okra, quinoa, pomegranate, perilla, perilla extract mixture and propolis and synthetic peptide.

The okra extract is characterized by the technical composition of the okra leaf and fruit extracted with water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane extracted with an extraction solvent selected from.

The quinoa extract is dried quinoa flowers, leaves, berries and seeds after extraction with an extraction solvent selected from water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane, and then filtered It is done.

The pomegranate extract is characterized in that the pomegranate powder: water is mixed in a weight ratio of 1: 2 to 10 and extracted by heating at 50 to 100 ° C. for 1 to 24 hours, followed by cold filtration of the obtained extract.

The perilla extract is characterized by the technical configuration that the filtered perilla extracted with ethanol at room temperature for 72 hours.

The cypress extract is characterized by the technical configuration that the filtered after extracting heated cypress branches and leaves to 70 ~ 80 ℃ with water.

The synthetic peptides are selected from the group consisting of Nicotinoyl Dipeptide, Palmitoyl pentapeptide, Copper tripeptide, Acetyl Hexa peptide, Tripeptide, Palrmitoyl Oligopeptide, HumanOligopeptide, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Tetrapeptide, Pentapeptide, Hexapeptide, and Oligapeptide. .

The skin cosmetic composition is a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, oil, pack, soap, shampoo, cleansing The technical composition is characterized by consisting of any one formulation selected from the group consisting of foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder and eye shadow.

Hereinafter will be described in detail with reference to the embodiments and drawings of the present invention so that those skilled in the art can easily practice. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention.

First, in the present invention, the okra (Hibiscus esculentus or belmoschus esculentus) is a plant belonging to the family Malvaceae, which is cultivated over tropical and subtropical regions, and is rich in fiber and contains a mixture of pectin galactam and araban in plants. This helps nourishment tonic and lowers blood cholesterol. Okra edible parts can be harvested in seven days after flowering with green pods, and peak at about 13 days after flowering. Okra pods are nutritionally about 90% water, about 15% protein, about 0.2% fat, about 0.7% inorganic salts, about 1.2% fiber, about 6.4% carbohydrates, about 88 mg of vitamin A, It is attracting attention as a nutritious green vegetable containing about 13mg of vitamin C.

Okra is known to be rich in vitamin C, which is good for recovery from fatigue. Since ancient times, leaves and unripe fruits have been used for a long time as a poultice medicine for pain relief. In addition, the polysaccharides of okra have been used in fields other than food (Ndjouenkeu, Goycoolea, Morris, & Akingbala, 1996; Tanaka et al., 2002; Woolfe, Chaplin, & Otchere, 1997). In the preparation of the complex extract of the present invention, the leaves, stems, roots and / or berries of okra may be used, and preferably the okra leaves and fruits are used.

The okra extract is extracted from the okra leaf and fruit with an extraction solvent selected from water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane, and then filtered.

Quinoa is a millet-sized round, smaller than rice, and is divided into white, red, brown, and black. In particular, red quinoa, called red quinoa, has higher protein and calcium content than other types of quinoa. Quinoa is a high protein food with an average of 16-20% of protein, which is the main source of protein for ancient Indians. Unlike other grains such as rice, barley, and wheat, it has little sodium and no gluten, so it does not cause allergic reactions. In particular, it contains high-quality protein and is considered to be a complete vegetable protein food that can replace the animal protein food milk.

In addition, nine kinds of essential amino acids such as lysine, methionine, arginine, and histidine are balanced in composition, which is excellent for nourishing the human body. In addition to the minerals and minerals such as calcium, potassium, phosphorus, iron, magnesium, manganese, zinc and selenium, it has abundant nutrients such as vitamins, fiber, starch. Lysine and phosphorus are the building blocks of muscle and skeleton to prevent osteoporosis, magnesium is to maintain blood pressure properly, and manganese and selenium are antioxidants to prevent aging.

The quinoa extract is dried after quinoa flowers, leaves, berries and seeds, and extracted with water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane extracted with an extraction solvent selected from, and then filtered.

Meanwhile, in the present invention, the pomegranate extract is obtained by extracting a pomegranate (Punicagranatum L.) which is a fruit of the pomegranate (Punicaceae). Pomegranate contains major amounts of glucose and fructose and contains citric acid (citric acid) to cleanse and circulate blood. In addition, it has abundant minerals that perform important functions in our body, such as calcium and potassium, and also contains vitamins such as vitamin B1, vitamin B2, and vitamin C. It also controls various functions and prevents diseases in the body. It is effective.

In particular, pomegranates contain isoflavones, which are phytoestrogens, which have the effect of anticipating the metabolic function of the skin, which delays skin aging and dryness due to female hormone deficiency.

The pomegranate extract is obtained by pulverizing and extracting seeds, shells, leaves, stems and shoots of the fruit and pomegranate obtained from the pomegranate tree, and is obtained by mixing the pomegranate powder with purified water and extracting it by heating. That is, pomegranate powder: purified water is mixed at a weight ratio of 1: 2 to 10, heated and extracted at 50 to 100 ° C. for 1 to 24 hours, and an extract obtained by cold filtration is used.

Perilla frutescens is an annual herb belonging to Laviatae. Perilla frutescens is used for perilla oil, tea, porridge and confectionery. Leafy vegetables are used for freshness, pickling and canning (Choung, MG, Comparison of major characteristics) between seed perilla and vegetable perilla, Korean J. Crop.Sci., 50, 171-174, 2005).

In addition, as perilla seeds germinate than normal mature vegetables, nutrients such as amino acids, fatty acids, carbohydrates, and antioxidants such as vitamins, minerals, and polyphenols have higher contents than those of seeds and maturation. Khalil, AW et al., Comparison of sprout quality characteristicsof desi and kabuli type chickpea cultivars (Cicer arietinum L.), LWTFood Sci. Technol., 40, 937-945, 2007.

In addition, perilla is rich in vitamins such as linolenic acid, an omega-3 fatty acid, and vitamins, which promote the brain's activity in the human body to help prevent dementia and its hematopoietic effect, which is effective in preventing anemia and hypotension as well as blood cholesterol. It has a beneficial effect on the prevention of arteriosclerosis or anti-inflammatory by reducing the effect, and also has an excellent effect on skin beauty and anti-aging.

Perilla, which has the above-mentioned physiologically active substances and efficacy, has been used to treat various diseases such as depression, tumors, coughs, antibacterial, antifungal and allergy for centuries as one of the traditional medicinal herbs.

That is, essential oil of perilla has been reported to have high antifungal activity, and major bioactive substances of perilla are known as tormentic acid (TA), oleanolic acid (OA) and ursolic acid (UA). Among these, TA has been reported to have anti-inflammatory effects and DNA polymerase inhibitory activity, OA and UA have also been reported to have anti-inflammatory effects, and OA has been reported to have liver protective effects and anti-tumor effects.

The perilla extract is extracted from perilla for 72 hours at room temperature with ethanol and filtered.

Phytoncide, on the other hand, is the Greek word for 'phyton' which means 'plant' and 'cide' which means 'kill'. In other words, substances that plants release or secrete to resist pathogens are called phytoncides. Plants are known to emit different phytoncide depending on the type of plant and the type of pathogen.

These phytoncides provide psychological stability, strengthen peripheral blood vessels, strengthen cardiopulmonary function, treat bronchial asthma and pulmonary tuberculosis, strengthen the heart, relieve stress, potent antibacterial action, deodorant action, sedation of fatigue, allergies and It is known to have an effect of improving skin diseases and enhancing immune function.

In other words, phytoncide has a strong sterilization effect, and it clears the air in the forest, and drinking the air phytoncide inhaled through the air selectively sterilizes bad bacteria in the human body, which makes our flesh and blood clear. This means smoothing our body's metabolism, not only refreshing our head but also our appetite.

A typical species that emits phytoncide is cypress, which is also called cypress, reaching 40m in height and 2m in diameter. Cypress is an evergreen arboretum native to Japan, also known as sashimi and hinoki. The bark is reddish brown, and small needle-shaped leaves are dense on the branches. Small flowers bloom on the branches in spring, and green conifers ripen in red in October. The conifer is 1 cm in diameter and consists of 7 to 9 shield pieces of vinyl. Leaves and wood contain 1% essential oil and are used for medicinal purposes.

The cypress extract is extracted by heating the cypress branches and leaves with water to 70 ~ 80 ℃, which is filtered, which heats the cypress leaves at a temperature higher than 80 ℃, phytoncide component contained in the cypress leaves Because it can be destroyed.

In addition, in the present invention, propolis is used as an antioxidant and salt-containing auxiliary ingredient, propolis (propolis) is a resin such as resin (꿀벌 아) extracted from various kinds of trees and herbs for honeybees their survival and breeding A generic term for complexes of various polymers produced by bees sticking to their hind legs, mixed with their saliva, and reacted with enzymes in the saliva, the main component being flavonoids. Flavonoids are anisozanins such as flavones, flavonones, flavonols, flavanols, flavanones and isoflavones and glycosides associated with sugars, hundreds of ansocyanins and glycosides associated with sugars, catechins as tannins And leucozancin. Propolis is B.C. Long ago 300 years ago, the ancient Egyptians used it effectively as an antiseptic to embalm mummies.These preservatives were used by moths, small rats, or snakes in the beehive, where they were killed by bees attack and then carried them out of the beehive. Failure to do so can be confirmed by natural observation that the propolis coated by the bees does not rot for years and the original remains intact. The non-preservative effects of propolis include anti-cancer, burn healing, eczema, atopic dermatitis and athlete's foot such as skin disease, hair loss inhibition, menstrual pain relief or elimination, constipation, skin care and wrinkle removal The ability to cure and prevent bacterial dental diseases such as dental caries, tooth decay, and oral infections has been reported. Based on this, the Ministry of Health and Welfare has recently defined health supplements in Korean Food Code 13-25. In addition, for flavonoids, the main ingredient of propolis, in 1969, Dr. Kavarkina's 5.6-fold increase in immunity effect was announced, and in 1973, a stronger bactericidal test was demonstrated than that of penicillin of Alexander Drople, Russia. Anti-inflammatory effect, 1994 anti-cancer effect clinical trials at Nihon Kogyo University, other systemic cell activation, hormonal stimulation activity, treatment of scurvy by vitamin P action, hypotensive action of hypertensive patients, balance of biological hormones The results of studies and clinical trials in countries around the world have been reported on their effectiveness.

On the other hand, the synthetic peptide is selected from Nicotinoyl Dipeptide, Palmitoyl pentapeptide, Copper tripeptide, Acetyl Hexa peptide, Tripeptide, Palrmitoyl Oligopeptide, HumanOligopeptide, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Tetrapeptide, Pentapeptide, Hexapeptide, Oligapept.

In addition, the skin cosmetic composition is a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, oil, pack, soap, shampoo Of course, it may be used in any one formulation selected from the group consisting of cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, latex, press powder, loose powder and eye shadow.

[Preparation of skin cosmetic composition of the present invention]

Okra extract: 10.0 g of mature okra fruit from which skin was removed was heated to 60 ° C. in purified water, and then immersed at this temperature for about 2 to 3 minutes, and then filtered to obtain 1.23 g of okra extract.

Quinoa extract: Quinoa fruit, 0.2 kg of seeds and extracts in ethanol and then filtered through a membrane filter to prepare a quinoa extract.

Pomegranate extract: The pomegranate powder was mixed with 3 times of water, heated and extracted at 100 ° C. for 24 hours, and filtered to obtain a pomegranate extract.

Perilla extract: Perilla was extracted with ethanol at room temperature for 72 hours and then filtered to obtain perilla extract.

Cypress extract: The cypress branches and leaves were extracted by heating to 70 ~ 80 ℃ with water and filtered to prepare a cypress extract.

After mixing Nicotinoyl Dipeptide and Palmitoyl pentapeptide as propolis and synthetic peptide to the extract prepared above, according to the conventional manufacturing method, the skin cosmetic composition (skin toner) of the present invention was prepared as shown in the following [Table 1].

[Cytotoxicity Evaluation of Skin Cosmetic Composition of the Present Invention]

In order to evaluate the cytotoxicity of the skin toner prepared in Example 1, 10,000 cells / well were dispensed per well for skin dermal fibroblasts (Human dermal fibroblast) in a 96well plate, and the survival rate of the cells for 24 hours was determined using the MTT method. Confirmed. Skin toner was injected into the experimental group by concentration, and culture medium was used for the negative control group. The results are shown in [FIG. 1].

As shown in FIG. 1, the survival rate of the dermal fibroblasts in the skin toner of the present invention is not toxic to the fibroblasts because they do not show a significant difference with the culture medium at the composition concentrations of 1, 3, and 5 vol%, respectively. It is confirmed.

[Evaluation of Skin Cosmetic Composition Stability of the Present Invention]

The stability of the skin toner prepared in Example 1 was obtained by placing the product in a transparent container, respectively, at high temperature (45 ° C), low temperature (-4 ° C), cycle (-4 to 45 ° C), and room temperature (25 ° C). Was observed after 4 weeks and the results are shown in [FIG. 2].

As shown in FIG. 1, it was confirmed that both high temperature, low temperature, cycle, and room temperature were stable under conditions, and no phenomenon such as separation or discoloration and odor was found.

The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and changes without departing from the essential characteristics of the present invention. Therefore, the embodiments and the drawings disclosed in the present invention are not intended to limit the technical spirit of the present invention but to explain, and the scope of the technical idea of the present invention is not limited by these embodiments and the drawings. The protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent scope should be interpreted as being included in the scope of the present invention.

Claims (8)

Contains okra, quinoa, pomegranate, perilla, cypress extract mixture and propolis and synthetic peptide,
The okra extract is filtered after extracting the okra leaves and fruits with an extraction solvent selected from water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane,
The quinoa extract is dried by quinoa flowers, leaves, berries and seeds and then extracted with an extraction solvent selected from water, ethyl alcohol, propylene glycol, butylene glycol, glycerin, chloroform, hexane, and filtered.
The pomegranate extract is a mixture of pomegranate powder: water in a weight ratio of 1: 2 to 10, and extracted by heating at 50 to 100 ° C. for 1 to 24 hours, followed by cold filtration of the extract obtained.
The perilla extract is filtered after extracting perilla with ethanol at room temperature for 72 hours,
The cypress extract is extracted by heating the cypress branches and leaves with water to 70 ~ 80 ℃,
The synthetic peptide is selected from the group consisting of Nicotinoyl Dipeptide, Palmitoyl pentapeptide, Copper tripeptide, Acetyl Hexa peptide, Tripeptide, Palrmitoyl Oligopeptide, HumanOligopeptide, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Tetrapeptide, Pentapeptide, Hexapeptide, Opiapeptide
delete delete delete delete delete delete The method of claim 1,
The skin cosmetic composition is a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, oil, pack, soap, shampoo, cleansing Skin cosmetic composition, characterized in that consisting of any one form selected from the group consisting of foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder and eye shadow

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