CN108379369A - A kind of small pox rehabilitation box - Google Patents

A kind of small pox rehabilitation box Download PDF

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Publication number
CN108379369A
CN108379369A CN201810528322.1A CN201810528322A CN108379369A CN 108379369 A CN108379369 A CN 108379369A CN 201810528322 A CN201810528322 A CN 201810528322A CN 108379369 A CN108379369 A CN 108379369A
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parts
beans
small pox
acne
rehabilitation box
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刘道忠
刘骞
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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Abstract

The invention belongs to technical field of Chinese medicine, provide a kind of small pox rehabilitation box, including by following drug：Minocycline, Ornidazole, beans beans bacteriostasis spray and the antibacterial aqua of beans beans, which is characterized in that its detailed directions is as follows：It takes within one day twice, each taking 100ml Chinese medicines acne clearing decoction, 50mg minocyclines and 0.5mg Ornidazoles；Simultaneously beans beans bacteriostasis spray or the antibacterial aqua of beans beans were sprayed in affected part every 46 hours.This small pox rehabilitation box is the understanding and principle of reatment with doctor trained in Western medicine to pathogenesis of acne mechanism based on modern Chinese medicine, selected Chinese and western medical raw material, it is formulated using unique formula, acne whelks can effectively be treated, it is significant in efficacy, it has no toxic side effect, obvious effective rate reaches 82% or more, total effective rate reaches 90% or more, and uneasy to recur.

Description

A kind of small pox rehabilitation box
Technical field
The invention belongs to technical field of Chinese medicine, more particularly to a kind of small pox rehabilitation box.
Background technology
Acne is commonly called as " whelk ", " whelk " measles risen in puberty face are easily mistakenly considered by majority, it crosses Puberty will self-healing.Just because of this, the acnes such as many patients influence beauty and just go to see the doctor." whelk " no in fact It it is singly puberty, childhood minority can also be happened at or the middle age." whelk " it is that patient facial region's pilosebaceous follicle is chronic Diseases associated with inflammation is one of most common disease of dept. of dermatology." whelk " if effective treatment not in time, develops as one pleases just It can influence the beautiful distinguished face of patient.Its morbidity is mainly largely secreted with sex hormone level, sebaceous glands, propionibacterium acnes are proliferated, The factors such as the dyskeratosis and inflammation of pilosebaceous duct are related.The illness is apt to occur in hebetic male and female, male Slightly more than women, but women morbidity is earlier than male.There is the teenager of 80-90% to suffer from acne, nature is tended to after puberty Decline or recovery from illness, few patients can also extend to 30 years old or more.Although acne is the disease for having self-healing to be inclined to, acne sheet Caused scar can seriously affect the quality of life of patient not in time for body and acne treatment, cause the stress of patient And financial burden, it need to cause to pay close attention to.Acne is apt to occur in cheek, forehead, cheek and nasolabial groove, followed by chest, back and shoulder Portion.
Existing medicine has Chinese medicine and Western medicine.In western medicine, antisterone, metronidazole, happy mould is mostly used greatly Element is treated, but curative effect is not notable.Chinese medicine thinks that acne is that lung channel is hot and suffocating, and interior heat is flourishing, outside caused by by ailment said due to cold or exposure, the rules for the treatment of Mainly mansion is led in facilitaing lung heat-clearing, dampness elimination.
Thus, the present invention select the preferably basic cipher prescription of therapy of combing traditional Chinese and Western medicine homeliness type acne curative effect, pass through by Oral Chinese and Western medicine is put on the skin with wet-dressing medicine combination in suit case, and designs a kind of small pox rehabilitation box outside.
Invention content
The purpose of the invention is to overcome the deficiencies in the prior art, and targetedly design a kind of small pox rehabilitation Box.
To achieve the above object, the present invention provides the following technical solutions：
A kind of small pox rehabilitation box, including by following drug：Minocycline, Ornidazole, beans beans bacteriostasis spray and beans beans are antibacterial Aqua, which is characterized in that its detailed directions is as follows：It takes within one day twice, it is happy each taking 100ml Chinese medicines acne clearing decoction, 50mg Mycin and 0.5mg Ornidazoles；Simultaneously beans beans bacteriostasis spray or the antibacterial aqua of beans beans were sprayed in affected part every 4-6 hours.
Preferably, the Chinese medicine acne clearing decoction, the weight proportion of material composition are as follows：8-15 parts of radix scutellariae, oldenlandia diffusa 15-20 parts, 10-20 parts of honeysuckle, 10-18 parts of Fructus Forsythiae, 12-20 parts of Radix Salviae Miltiorrhizae, 15-25g parts of radix paeoniae rubra, 15-25 parts of dandelion, life 10-20 parts of hawthorn.
Preferably, the traditional Chinese herbal decoction includes ingredient as following formula according to mass fraction：12 parts of radix scutellariae, oldenlandia diffusa 20 parts, 15 parts of honeysuckle, 15 parts of Fructus Forsythiae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of radix paeoniae rubra, 20 parts of dandelion, 15 parts of raw hawthorn.
Preferably, the preparation method of the traditional Chinese herbal decoction is：It is equipped with each raw material according to said program and is crushed with pulverizer It is spare at fine powder, then each fine powder is mixed well, auxiliary material is added, routinely preparation process is made various in materia medica meaning Peroral dosage form.
Modern Western medicine thinks, this disease is mainly with androgen and sebaceous glands hyperfunction, the taste of microorganism in hair follicle sebum Raw, it is related that the immune function of host is low etc..Modern Chinese herbal medicine thinks that face nose category lung, wind and heat in the lung meridian, powder can be caused in skin by fumigating Thorn.The rules for the treatment of need facilitaing lung heat-clearing, dampness elimination to lead to mansion.
Modern pharmacology research proves：
Honeysuckle, radix scutellariae, Radix Salviae Miltiorrhizae, heat-clearing accompany, eliminating dampness, invigorate blood circulation as monarch drug in a prescription.Wherein, honeysuckle is sweet in flavor cold in nature, heat-clearing solution Poison can be individually used for treatment furunculosis；Radix scutellariae is sweet in flavor cold in nature, heat-clearing and damp-drying drug, purging intense heat and detonicating；Radix Salviae Miltiorrhizae bitter cold nature, invigorates blood circulation, dispels The stasis of blood, cool blood to disappear carbuncle.
Dandelion, oldenlandia diffusa, Fructus Forsythiae are clearing heat and detoxicating, are altogether adjuvant.Wherein dandelion bitter but sweet flavor is cold in nature, there is heat-clearing It the effect of removing toxic substances, dampness removing, associates with honeysuckle, the clearing heat and detoxicating effect of honeysuckle can be reinforced；Oldenlandia diffusa bitter is cold in nature, Clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness；Fructus Forsythiae bitter is cold in nature, clearing heat and detoxicating, dissipating bind, detumescence, control warm, erysipelas, macula, Large carbuncle pyogenic infections.
Radix paeoniae rubra, raw hawthorn strengthening the spleen and stomach, it is eliminating dampness and eliminating phlegm, it is altogether adjutant.Radix paeoniae rubra hardship is slightly cold, and clearing heat and cooling blood, promoting blood circulation is dispelled The stasis of blood；The slightly sour puckery relieving dyspepsia of raw hawthorn taste, phlegm reduction of blood circulation promoting.Radix paeoniae rubra is associated with radix scutellariae, the effect of capable of reinforcing monarch drug in a prescription heat-clearing and damp-drying drug.
Minocycline, alias Minocycline Hydrochloride Capsules in Healthy Volunteers are semi-synthetic tetracycline antibiotic, and antibacterial action is at Fourth Ring It is relatively strong in plain class antibiotic.This product to gram-positive bacteria, including the staphylococcus aureus of tetracycline resistant strain, streptococcus, Diplococcus meningitidis etc. is highly sensitive, also very strong to the effect of gram-negative gonococcus, to chlamydia trachomatis and molten urea branch Substance also has preferable bacteriostasis.It is generally weaker to the effect of gram-Negative bacillus.This product is applicable to treatment acne.
Ornidazole is the novel nitro imidazole derivatives of the third generation after metronidazole, Tinidazole, is had good Anaerobe resistant and anti-trichomonal effect.The active compound and intermediate metabolites of Ornidazole are active, act on anaerobic bacteria, amoeba worm, The DNA of giardia lamblia and trichmonad cell makes its helical structure be broken or block its transcription to replicate and lethal die.
This drug has the effect of dry poison of heat-clearing, eliminating dampness, cooling and activating blood, can reach the purpose of effectively treatment acne whelks.
The advantages of the present invention and advantage are：
1. the data scheme of the present invention based on modern Chinese medicine and doctor trained in Western medicine to the understanding and principle of reatment of pathogenesis of acne mechanism, Selected Chinese and western medical raw material, is formulated using unique formula, can effectively treat acne whelks, significant in efficacy, nontoxic pair Effect, obvious effective rate reach 82% or more, and total effective rate reaches 90% or more, and uneasy to recur.
2. small pox rehabilitation box of the present invention by by oral Chinese and Western medicine, put on the skin outside with wet-dressing medicine combination in suit case, facilitate trouble Person carries treatment.
Specific implementation mode
Product of the present invention is further described below in conjunction with structure of the invention and embodiment, the description of embodiment is only It is easy to understand and with the application of the invention, rather than to the limitation of the invention protected.Unless stated otherwise, the % in the present invention is matter Measure percentage；Unless stated otherwise, preparation process carries out under room temperature, normal pressure state；Unless stated otherwise, it is adopted in the present invention Reagent, method and apparatus are the art conventional reagent, method and apparatus；Unless stated otherwise, it is adopted in the present invention Experimental condition is the art normal test conditions；Unless stated otherwise, agents useful for same is purchased in market in the present invention.
It is prepared by 1 traditional Chinese herbal decoction of embodiment
Prescription：12 parts of radix scutellariae, 20 parts of oldenlandia diffusa, 15 parts of honeysuckle, 15 parts of Fructus Forsythiae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of radix paeoniae rubra, 20 parts of dandelion, 15 parts of g of raw hawthorn.
Preparation method：It is spare then each fine powder is abundant that each raw material in the drug with pulverizer is ground into fine powder Auxiliary material is added in mixing, and routinely the various peroral dosage forms in materia medica meaning are made in preparation process.
To verify curative effect of the present invention, inventor has carried out in 2012-2016 in Wuhan City, Hubei Province Li Ji hospitals as follows Clinical trial：
1. clinical data：
The acne patient totally 82 of selection the slight of age 15-25 Sui, moderate, the severe state of an illness, is randomly divided into two Group, one group is treatment group, amounts to 42, and another group is control group, amounts to 40.
2. document method：
Treatment group uses this small pox rehabilitation box：Take within i.e. one day 15-25ml Chinese medicines acne clearing decoction, 50mg minocyclines twice With Ornidazole 0.5mg, each one；Simultaneously beans beans bacteriostasis spray or the antibacterial aqua of beans beans were sprayed in affected part every 4-6 hours.
Control group uses western medicine, antisterone 25mg, metronidazole 25mg, minocycline 40mg to take orally, daily two Secondary oral, January is as a treatment course.
3. curative effect judging standard
A. significantly：Clinical cure, skin lesion are all subsided, and subjective symptoms disappears or there are pigmentation and scars；
B. effectively：30% or more skin lesion recession, subjective symptoms is substantially reduced；
C. invalid:Skin lesion and symptom are unchanged, and subjective symptoms recession shape is less than 30%.
4. therapeutic effect：
Table one：Therapeutic effect
Significantly Effectively In vain It is total
Treatment group 32 8 2 42
Control group 12 10 18 40
It can be seen that from one data of table：
One, treatment group：Obvious effective rate is 76.2%；Effective percentage is 19%；Inefficiency is 4.8%.
Two, control group：Obvious effective rate is 30%；Effective percentage is 25%；Inefficiency is 45%.
The above is only the preferred application implementation mode of the present invention, it is noted that for the common skill of the art For art personnel, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvement Protection scope of the present invention is also should be regarded as with retouching.

Claims (4)

1. a kind of small pox rehabilitation box, including by following drug：Minocycline, Ornidazole, beans beans bacteriostasis spray and beans beans bacteriostatic water Agent, which is characterized in that its detailed directions is as follows：It takes within one day twice, it is mould each taking 100ml Chinese medicines acne clearing decoction, 50mg happinesses Element and 0.5mg Ornidazoles；Simultaneously beans beans bacteriostasis spray or the antibacterial aqua of beans beans were sprayed in affected part every 4-6 hours.
2. a kind of small pox rehabilitation box according to claim 1, which is characterized in that the Chinese medicine acne clearing decoction, material composition Weight proportion is as follows：8-15 parts of radix scutellariae, 15-20 parts of oldenlandia diffusa, 10-20 parts of honeysuckle, 10-18 parts of Fructus Forsythiae, Radix Salviae Miltiorrhizae 12-20 Part, 15-25g parts of radix paeoniae rubra, 15-25 parts of dandelion, 10-20 parts of raw hawthorn.
3. a kind of small pox rehabilitation box according to claim 2, which is characterized in that the traditional Chinese herbal decoction, according to mass fraction Including ingredient as following formula：12 parts of radix scutellariae, 20 parts of oldenlandia diffusa, 15 parts of honeysuckle, 15 parts of Fructus Forsythiae, 15 parts of Radix Salviae Miltiorrhizae, radix paeoniae rubra 15 Part, 20 parts of dandelion, 15 parts of raw hawthorn.
4. a kind of small pox rehabilitation box according to claim 2, which is characterized in that the preparation method of the traditional Chinese herbal decoction is： It is spare that it is ground into fine powder according to each raw material of said program outfit and with pulverizer, then each fine powder is mixed well, auxiliary material is added, presses The various peroral dosage forms in materia medica meaning are made in conventional formulation technique.
CN201810528322.1A 2018-05-29 2018-05-29 A kind of small pox rehabilitation box Pending CN108379369A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103705603A (en) * 2014-01-07 2014-04-09 王东海 Traditional Chinese medicine for treating acne
CN107260844A (en) * 2017-06-26 2017-10-20 刘骞 A kind of bacteriostasis spray

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103705603A (en) * 2014-01-07 2014-04-09 王东海 Traditional Chinese medicine for treating acne
CN107260844A (en) * 2017-06-26 2017-10-20 刘骞 A kind of bacteriostasis spray

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
曹化章: "中药内服外敷治疗寻常痤疮67例 ", 《河南中医》 *

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