CN103908617A - Medicinal liquid for treating recurrent oral ulcer - Google Patents
Medicinal liquid for treating recurrent oral ulcer Download PDFInfo
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- CN103908617A CN103908617A CN201410108187.7A CN201410108187A CN103908617A CN 103908617 A CN103908617 A CN 103908617A CN 201410108187 A CN201410108187 A CN 201410108187A CN 103908617 A CN103908617 A CN 103908617A
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- medicinal liquid
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- fructus
- alpiniae oxyphyllae
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Abstract
The invention discloses medicinal liquid for treating recurrent oral ulcer, which is prepared by raw materials and excipients; the raw materials comprise, by weight, 60-85 parts of corncobs, 42-60 parts of mung beans, 9-16 parts of cape jasmine, 8-13 parts of fructus alpiniae oxyphyllae, and 20-35 parts of bamboo leaves. The medicinal liquid of the invention has significant efficacy on recurrent oral ulcer, not only can rapidly alleviate congestion and pain, accelerate ulcer heal, but also can effectively control recurrence.
Description
Technical field
The invention belongs to Chinese medicine technical field, in particular to a kind of external used medicine for the treatment of oral ulcer, relate in particular to a kind of medicinal liquid for the treatment of recurrent oral ulceration.
Background technology
Recurrent oral ulceration (recurrentoralulcer, ROU) claims again recurrent aphtha (recurrent aphthousulcer, RAU), is department of stomatology common disease.Patient, due to the infringement of oral mucosa repeatability ulcer, pain, is difficult to recovery from illness, and its concrete pathogenesis is still not clear, may be relevant to the disorder of immune mechanism of body, cause of disease complexity is various, and throughout the year, no matter men and women, no matter the age all can fall ill, and brings tremendous influence to people's quality of life.At present clinically never have perfect treatment measure for this disease, be confined to symptomatic treatment more.Traditional treatment compound vitamin B sheet adds hormone therapy, and its curative effect is undesirable, and relapse rate is high.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to by secret recipe handed down in the family is carried out to lot of experiments research and improvement, thereby a kind of medicinal liquid that effects a radical cure recurrent oral ulceration is provided.
The object of the present invention is achieved like this:
Treat a medicinal liquid for recurrent oral ulceration, be prepared from by raw material and excipient, by weight, described raw material comprises: corn cob 60-85 part, Semen phaseoli radiati 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13 part, Folium Bambusae 20-35 part.
Preferably, treat as mentioned above the medicinal liquid of recurrent oral ulceration, its by weight, described raw material is made up of corn cob 68-76 part, Semen phaseoli radiati 48-53 part, Fructus Gardeniae 11-13 part, Fructus Alpiniae Oxyphyllae 9-11 part and Folium Bambusae 25-29 part.
In a most preferred embodiment of the present invention, treat as mentioned above the medicinal liquid of recurrent oral ulceration, its by weight, described raw material is made up of 27 parts, 72 parts of corn cobs, 50 parts, Semen phaseoli radiati, 12 parts of Fructus Gardeniaes, 10 parts of Fructus Alpiniae Oxyphyllae and Folium Bambusae.
Further preferably, treat as mentioned above the medicinal liquid of recurrent oral ulceration, excipient wherein comprises glycerol and antiseptic, and described antiseptic is preferably ethyl hydroxybenzoate.
The preparation method of the oral cavity medicinal liquid the present invention relates to comprises the steps: to take corn cob 60-85 part, Semen phaseoli radiati 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13 part and Folium Bambusae 20-35 part, cleans roguing, dries, be ground into granule, with bundle it, put in people's container, add 15-18 times of water, soak after 30 minutes and decoct to boiling, continue 25-40 minute, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio that is 1:2-4 in mass volume ratio adds 25-35%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30-60min.
It should be noted that, raw material of the present invention has following source: corn cob is selected the excellent core after gramineous herbaceous plant's beautiful sorghum broomcorn millet white maize rod threshing.Semen phaseoli radiati is selected the seed of leguminous plant Semen phaseoli radiati.Fructus Gardeniae is selected the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Fructus Alpiniae Oxyphyllae is selected the mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.Folium Bambusae is selected the dried leaves of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.
By experimental results demonstrate, the stable curative effect of liquid medicine applying recurrent oral ulceration of the present invention, relapse rate is low, substantially has no side effect.Therefore, the present invention also provides a kind of new use of product, that is: the application of above-mentioned medicinal liquid in the external used medicine of preparation treatment recurrent oral ulceration.Preferably described external used medicine is cream, spray.
Compared with prior art, the medicinal liquid the present invention relates to is evident in efficacy to recurrent oral ulceration, can not only alleviate rapidly congested pain, accelerates ulcer healing, and effective Control in recurring, after treating, follows up a case by regular visits to and no longer recurs half a year.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Take corn cob 720g, Semen phaseoli radiati 500g, Fructus Gardeniae 120g, Fructus Alpiniae Oxyphyllae 100g and Folium Bambusae 270g, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, soak after 30 minutes and decoct to boiling, continue 40 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio that is 1:3 in mass volume ratio adds 33%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 2
Take corn cob 800g, Semen phaseoli radiati 420g, Fructus Gardeniae 90g, Fructus Alpiniae Oxyphyllae 100g and Folium Bambusae 200g, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, soak after 30 minutes and decoct to boiling, continue 30 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio that is 1:2 in mass volume ratio adds 25%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 3
Take corn cob 850g, Semen phaseoli radiati 580g, Fructus Gardeniae 150g, Fructus Alpiniae Oxyphyllae 130g and Folium Bambusae 250g, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 18 times of water, soak after 30 minutes and decoct to boiling, continue 40 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio that is 1:4 in mass volume ratio adds 33%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 4
Take corn cob 600g, Semen phaseoli radiati 550g, Fructus Gardeniae 120g, Fructus Alpiniae Oxyphyllae 80g and Folium Bambusae 350g, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, soak after 30 minutes and decoct to boiling, continue 40 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio that is 1:3 in mass volume ratio adds 33%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Comparative example
Take Semen phaseoli radiati 500g, Fructus Gardeniae 120g and Folium Bambusae 270g, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, soak after 30 minutes and decoct to boiling, continue 40 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtains extract, for subsequent use; Take extract, the ratio that is 1:3 in mass volume ratio adds 33%(v/v) glycerine water solution, and add appropriate antiseptic ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Clinical practice example
Get rid of immunologic hypofunction, patients with connective tissue diseases, use glucocorticoid and immunosuppressant person and have other parts or whole body systemic disease person after, meet 58 routine patients of recurrent oral ulceration diagnostic criteria, wherein male 26 examples, female's 31 examples, 23～57 years old age.All patients are divided into test A group (29 example) and test B group (29 example) at random.Two groups are compared there was no significant difference at the aspect such as sex, age.
Test A group patient adopts dry cotton swab to pick the appropriate medicinal liquid of getting ready (being prepared from according to the prescription of above-described embodiment 1 and technique) on the basis of oral vitamin B5mg/d, is applied to lightly oral ulcer position.After coating, remain silent, can not gargle immediately, drinking-water and feed.Medication every day 3 times one week is a course for the treatment of.
Test B group patient adopts dry cotton swab to pick the appropriate medicinal liquid of getting ready (being prepared from according to above-mentioned comparative example's prescription and technique) on the basis of oral vitamin B5mg/d, within one week, is a course for the treatment of.
Two groups of patients all treated after the course for the treatment of, carried out therapeutic outcome statistics by following curative effect judging standard:
Effective: treat ulcer in latter 5 days and substantially heal, congested pain disappears substantially; Effective: in 5 days, ulcer area is obviously dwindled, congested pain obviously alleviates; Invalid: after 5 days, ulcer area, hyperemia, pain are not improved.
Two groups of curative effects are relatively in table 1.Can find out by table 1, adopt the treatment of medicinal liquid of the present invention for recurrent oral ulceration, the liquid medicine applying of comparing comparative example has better curative effect.In addition, test A group patient follows up a case by regular visits to half a year, and no case was recurrence.
Table 1 liang group curative effect comparison
Claims (5)
1. treat the medicinal liquid of recurrent oral ulceration for one kind, it is characterized in that: be prepared from by raw material and excipient, by weight, described raw material comprises: corn cob 60-85 part, Semen phaseoli radiati 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13 part, Folium Bambusae 20-35 part.
2. the medicinal liquid for the treatment of according to claim 1 recurrent oral ulceration, is characterized in that: by weight, described raw material is made up of corn cob 68-76 part, Semen phaseoli radiati 48-53 part, Fructus Gardeniae 11-13 part, Fructus Alpiniae Oxyphyllae 9-11 part and Folium Bambusae 25-29 part.
3. the medicinal liquid for the treatment of according to claim 2 recurrent oral ulceration, is characterized in that: by weight, described raw material is made up of 27 parts, 72 parts of corn cobs, 50 parts, Semen phaseoli radiati, 12 parts of Fructus Gardeniaes, 10 parts of Fructus Alpiniae Oxyphyllae and Folium Bambusae.
4. the application of the medicinal liquid described in claim 1 or 2 or 3 in the external used medicine of preparation treatment recurrent oral ulceration.
5. application according to claim 4, is characterized in that: described external used medicine is cream, spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410108187.7A CN103908617B (en) | 2014-03-21 | 2014-03-21 | A kind of medicinal liquid treating recurrent oral ulceration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410108187.7A CN103908617B (en) | 2014-03-21 | 2014-03-21 | A kind of medicinal liquid treating recurrent oral ulceration |
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| Publication Number | Publication Date |
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| CN103908617A true CN103908617A (en) | 2014-07-09 |
| CN103908617B CN103908617B (en) | 2016-08-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410108187.7A Expired - Fee Related CN103908617B (en) | 2014-03-21 | 2014-03-21 | A kind of medicinal liquid treating recurrent oral ulceration |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038740A (en) * | 2009-10-09 | 2011-05-04 | 吴海洋 | Formula for treating aphtha |
| CN102671039A (en) * | 2012-04-04 | 2012-09-19 | 张敏丽 | Chinese medicinal composition for treating aphtha of mouth and tongue |
| CN102772693A (en) * | 2012-08-21 | 2012-11-14 | 孙凤梅 | Medicine for treating recurrent oral ulcer and preparation method thereof |
-
2014
- 2014-03-21 CN CN201410108187.7A patent/CN103908617B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038740A (en) * | 2009-10-09 | 2011-05-04 | 吴海洋 | Formula for treating aphtha |
| CN102671039A (en) * | 2012-04-04 | 2012-09-19 | 张敏丽 | Chinese medicinal composition for treating aphtha of mouth and tongue |
| CN102772693A (en) * | 2012-08-21 | 2012-11-14 | 孙凤梅 | Medicine for treating recurrent oral ulcer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 陈文芳等: "口溃愈汤治疗复发性口腔溃疡疗效观察", 《实用中医药杂志》, vol. 29, no. 10, 31 December 2013 (2013-12-31), pages 813 * |
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| CN103908617B (en) | 2016-08-17 |
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