CN105770002A - Nose spraying water and preparing method thereof - Google Patents
Nose spraying water and preparing method thereof Download PDFInfo
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- CN105770002A CN105770002A CN201610231398.9A CN201610231398A CN105770002A CN 105770002 A CN105770002 A CN 105770002A CN 201610231398 A CN201610231398 A CN 201610231398A CN 105770002 A CN105770002 A CN 105770002A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention relates to nose spraying water.The nose spraying water comprises, by weight, 10-60 parts of common andrographis herbs, 10-60 parts of glabrous sarcandra herbs, 0.2-3 parts of borneol, 5-30 parts of flos magnoliae liliflorae, 0.2-1.2 parts of ephedra herbs and 0.2-0.9 part of venenum bufonis.The invention further relates to a preparing method of the nose spraying water.The preparing method includes the steps that the active ingredients in the common andrographis herbs and the active ingredients in the glabrous sarcandra herbs are extracted with the supercritical fluid extraction method, the active ingredients in ephedra herbs are extracted with the ethanol reflux extract method, the active ingredients in the flos magnoliae liliflorae are extracted with the steam distillation method, the borneol and the venenum bufonis are smashed, absolute ethyl alcohol and distilled water are added, the mixture is mixed to be even and subjected to split charging, and the nose spraying water is obtained.The nose spraying water is simple in formula, rapid in effect taking and safe in use, discharging of purulent secretion in the nose cavity can be effectively promoted, the medicine effect of single medicine using can be continuously kept for 12 hours or above, and the curing rate is high.The preparing method of the nose spraying water is high in extracting efficiency, free of residual organic solvents in the extracting process and suitable for mass production.
Description
Technical field
The invention belongs to field of medicinal compositions, be specifically related to a kind of spray snot and preparation method thereof.
Background technology
In recent years, along with atmospheric pollution constantly aggravates, various pathogenic microorganisms in air and anaphylactogen
Quantity increases, and the sickness rate of various nasal cavity inflammations is gradually increasing.
Nasal cavity inflammation refers to by virus, antibacterial, allergen, various physical and chemical factor and some systemic disease
The inflammation of the bronchia mucosal caused, including multiple kinds, as chronic simple rhinitis, chronic hypertrophic rhinitis,
Atrophic rhinitis etc..Nasal cavity inflammation not only can bring the symptoms such as nasal obstruction, watery nasal discharge, headache, hyposmia, and
And multiple complications can be caused.Meanwhile, nasal cavity inflammation easily recurs, and is difficult to cure, has a strong impact on patient's
The activities such as normal work, study.
The medicine of the most conventional treatment rhinitis has a variety of, including electuary for oral administration, pill and externally applied spray
Deng.Endo-medicine after digestive tract decomposes, then must deliver to nasal membrane through systemic circulation, arrives nose
Dose is little, and medication is inefficient.And external used medicine is typically only capable to temporarily improve nasal airflow situation, single
After medication, duration of efficacy is shorter, needs repeatedly medication every day, uses inconvenience.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of spray snot and preparation side thereof
Method.Described spray snot formula is simple, and onset is rapid, uses safety, it is possible to effectively facilitate nasal cavity purulence and divide
The discharge of secretion, the drug effect of single medication can continue more than 12 hours, and cure rate is high.Described spray snot
Preparation method extraction efficiency is high, extracts process organic solvent-free residual, is suitable for a large amount of production.
The technical solution adopted in the present invention is:
A kind of spray snot, the raw material components of employing includes:
Herba Andrographis 10-60 weight portion, Herba Sarcandrae 10-60 weight portion, Borneolum Syntheticum 0.2-3 weight portion, Flos Magnoliae 5-30
Weight portion, Herba Ephedrae 0.2-1.2 weight portion, Venenum Bufonis 0.2-0.9 weight portion.
Further, the raw material components of employing includes:
Herba Andrographis 10-20 weight portion, Herba Sarcandrae 10-20 weight portion, Borneolum Syntheticum 0.2-1 weight portion, Flos Magnoliae 5-10
Weight portion, Herba Ephedrae 0.2-0.4 weight portion, Venenum Bufonis 0.2-0.3 weight portion.
Further, the raw material components of employing includes:
Herba Andrographis 10 weight portion, Herba Sarcandrae 12 weight portion, Borneolum Syntheticum 0.2 weight portion, Flos Magnoliae 6 weight portion,
Herba Ephedrae 0.2 weight portion, Venenum Bufonis 0.2 weight portion.
The preparation method of a kind of described spray snot, comprises the following steps:
(1) Herba Andrographis, Herba Sarcandrae, Flos Magnoliae and Herba Ephedrae, sterilizing are weighed according to above weight portion；
(2) each raw material components after the sterilizing of gained in step (1) is separately dried, pulverizes, sieve,
Obtain Herba Andrographis coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and Herba Ephedrae coarse granule；
(3) the Herba Andrographis coarse granule of gained in step (2) is put in supercritical extraction tank, seal, fill
Enter carbon dioxide, extract, separate, obtain Herba Andrographis extract；
The Herba Sarcandrae coarse granule of gained in step (2) is put in supercritical extraction tank, seals, be filled with dioxy
Change carbon, extract, separate, obtain Herba Sarcandrae extract；
Take the Herba Ephedrae coarse granule of gained in step (2), carry out alcohol reflux, obtain Herba Ephedrae extract；
Take the Flos Magnoliae coarse granule of gained in step (2), carry out vapor distillation extraction, obtain Flos Magnoliae and carry
Take oil；
(4) weigh Borneolum Syntheticum and Venenum Bufonis, sterilizing according to above weight portion, pulverize standby；
(5) by the Herba Andrographis extract of gained in step (3), Herba Sarcandrae extract, Herba Ephedrae extract,
In Flos Magnoliae caul-fat and step (4), Borneolum Syntheticum and Venenum Bufonis after the pulverizing of gained are sufficiently mixed, and are mixed
Thing, adds dehydrated alcohol and distilled water in described mixture, is sufficiently mixed, filter, subpackage, obtain institute
State spray snot.
Further, the sterilizing methods used in step (1) is moist hear heat test, described moist hear heat test
Sterilising temp is 121 DEG C, and sterilization time is 30min.
Further, step (2) use drying mode each raw material components of gained in step (1) is entered
Row is dried, and baking temperature is 70-80 DEG C, and drying time is 6-8 hour；After pulverizing and sieving, gained Herba Andrographis
Coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and the coarse grained particle size of Herba Ephedrae are 20-80 mesh.
Further, when step (3) carries out supercritical extraction to described Herba Andrographis coarse granule, use dioxy
The flow changing carbon is 2-10Kg/h, and extraction temperature is 45-60 DEG C, and extraction time is 2-3h, and extracting pressure is
25-35MPa, separating pressure is 4-8MPa, and separation temperature is 40-45 DEG C；
When described Herba Sarcandrae coarse granule is carried out supercritical extraction, the flow of the carbon dioxide of employing is
4-15Kg/h, extraction temperature is 50-65 DEG C, and extraction time is 2-3h, and extracting pressure is 25-40MPa, point
Tripping power is 5-10MPa, and separation temperature is 30-40 DEG C；
When described Herba Ephedrae coarse granule is carried out alcohol reflux, in described Herba Ephedrae coarse granule, add 8-10 times
Amount volume fraction is the ethanol of 80%, reflux, extract, 2-3 time, and each 1-2h merges, and ethanol is reclaimed in evaporation,
Obtain described Herba Ephedrae extract；
When described Flos Magnoliae coarse granule carries out vapor distillation extraction, Extracting temperature is 102-108 DEG C, extracts
Time is 12-16h, and the oil water mixture obtained after being condensed by product of distillation is separated by centrifugation, obtains
Flos Magnoliae extracts oil.
Further, step (4) uses60Co irradiation sterilization mode carries out sterilizing to Borneolum Syntheticum and Venenum Bufonis,
Irradiation dose is 4-6kGy；After described Borneolum Syntheticum and Venenum Bufonis are pulverized, grain size is 50-100 μm.
Further, the amount adding dehydrated alcohol in step (5) is 80-150 weight portion, adds distilled water
Amount be described mixture and 8 times of the gross weight of the described dehydrated alcohol of addition；Use intensification alr mode
By described mixture mix homogeneously, speed of agitator is 100-200r/min, and whipping temp is 30-40 DEG C, stirring
Time is 1-3h；Filter the aperture of filter screen a size of 150-200 mesh used.
Described intensification alr mode refers to heat the mixture to uniform temperature, then in certain speed of agitator condition
Under be stirred.
Herba Andrographis is Acanthaceae Herba Andrographis platymiscium, and pharmaceutical leaf or herb have heat-clearing and toxic substances removing, antiinflammatory, disappear
The effect of swollen pain relieving, it is possible to be used for treating gastrointestinal tract and respiratory tract infection, heating, herpes, throat pain and each
Plant bacterial infection.
Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye, and property is put down, and feeble QI is fragrant, and taste is micro-pungent, has
Antibacterial, antiinflammatory, removing heat from blood, heat-clearing and toxic substances removing, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation, immunosuppressant curative effect, and tool
There are antitussive, the effect eliminated the phlegm, relieving asthma.
Borneolum Syntheticum is water white transparency or white obtained by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf refine
Crystallization that the translucent lamellar of color is crisp；Gas delicate fragrance, acrid in the mouth, cool in nature, have refreshment of having one's ideas straightened out, heat clearing away dissipate poison,
Improving acuity of vision and removing nebula, effect of reducing swelling and alleviating pain.
Flos Magnoliae is the dry flower of Magnoliacea plant Y biondii(Pamp)D.L.Fu., Magnolia denudata, Flos Magnoliae etc., warm in nature, taste
Pungent, there is dispersing wind and cold；Effect of clearing the nasal passage, it is possible to be used for treating the diseases such as nasal obstruction, watery nasal discharge, headche due to wind-cold.
Herba Ephedrae is the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina, warm in nature, acrid in the mouth,
Micro-hardship, has effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, can treat anemofrigid cold, uncomfortable in chest breath with cough
The diseases such as edema due to wind pathogen edema, bronchial asthma.
Venenum Bufonis is the processed dry gained of secretions of Bufo siccus epidermal gland.Sweet in the mouth, pungent, warm in nature, feeble QI raw meat,
That smells sneezes, have removing toxic substances, ease pain, have one's ideas straightened out, the several functions such as antitumor, outer can promote for nasal cavity
Nasal cavity ciliary movement, discharges secretions.
Using method:
After every day cleans nasal cavity, use described spray snot that left nare and right naris are respectively sprayed medicine once.
It it was a course for the treatment of with two weeks.
Beneficial effect:
1, the raw material components that described spray snot uses includes Herba Andrographis, Herba Sarcandrae, Borneolum Syntheticum, Flos Magnoliae, Herba Ephedrae
And Venenum Bufonis, described Venenum Bufonis can promote patient's sneeze, effectively the purulent secretion of discharge nasal cavity, meanwhile,
Coordinate Flos Magnoliae and Herba Ephedrae, it is possible to dredge clearing the nasal passage, shrink nasal cavity blood vessel, improve nasal airflow situation；Described
Herba Andrographis, Herba Sarcandrae and Borneolum Syntheticum are respectively provided with heat-clearing and toxic substances removing, the effect of anti-inflammatory analgetic, and three is with the use of can
Effectively eliminate nasal membrane swelling, subside a swelling antiinflammatory, simultaneously Borneolum Syntheticum abnormal smells from the patient delicate fragrance, refreshment of having one's ideas straightened out, contact nasal cavity
Refrigerant comfortable sense can be brought afterwards, alleviate the zest of spray snot, then coordinate the gas of the delicate fragrance of Flos Magnoliae,
The comfort of spray snot can be effectively improved.Described spray snot directly acts in nasal cavity, drug absorption
Rate is high, and onset is rapid, and medication can alleviate Rhinitis Symptoms the same day, and the duration of efficacy of single medication exceedes
12h, cure rate is high.
2, the method preparing described spray snot includes sterilizing, supercritical extraction, reflux, extract, and distillation extraction
Etc. step, disinfecting action can effectively ensure that the hygienic quality of products obtained therefrom, improves product storage duration；Super
Critical extraction process extraction efficiency is higher, extracts fully for the active substance in each raw material, the product obtained
Middle organic solvent-free remains, and does not results in product and environmental pollution；Reflux, extract, and distillation extraction can have
Effect extracts the effective ingredient in corresponding medicinal raw material, and cost is relatively low, is suitable for batch production.
Detailed description of the invention
Detailed description below can illustrate in greater detail the present invention, but limits the present invention the most in any form.
In following example, with 1 weight portion as 1g.
Embodiment 1
A kind of spray snot, the raw material components of employing includes:
Herba Andrographis 10 weight portion, Herba Sarcandrae 20 weight portion, Borneolum Syntheticum 0.2 weight portion, Flos Magnoliae 15 weight portion,
Herba Ephedrae 0.5 weight portion, Venenum Bufonis 0.2 weight portion.
The preparation method of the above spray snot, comprises the following steps:
(1) weigh Herba Andrographis, Herba Sarcandrae, Flos Magnoliae and Herba Ephedrae according to above weight portion, use moist heat sterilization
Method carries out sterilizing to above raw material, and sterilising temp is 121 DEG C, and sterilization time is 30min；
(2) each raw material components after the sterilizing of gained in step (1) is respectively placed in drying baker,
Under the conditions of 70 DEG C, it is separately dried 6 hours；Again above each raw material components is pulverized respectively, sieve, worn
Heart lotus coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and Herba Ephedrae coarse granule, the above is coarse grained
Particle size is 20-80 mesh；
(3) the Herba Andrographis coarse granule of gained in step (2) is put in supercritical extraction tank, seal,
The flow of carbon dioxide is 5Kg/h, and extraction temperature is 45 DEG C, and extracting pressure is to carry out under conditions of 30MPa
Carbon dioxide supercritical fluid extraction, extraction time is 2h；Being 4MPa at separating pressure afterwards, separation temperature is
Separate under conditions of 40 DEG C, obtain Herba Andrographis extract；
The Herba Sarcandrae coarse granule of gained in step (2) is put in supercritical extraction tank, seals, in titanium dioxide
The flow of carbon is 4Kg/h, and extraction temperature is 50 DEG C, and extracting pressure is to carry out titanium dioxide under conditions of 25MPa
Carbon supercritical extraction, extraction time is 2h；Being 5MPa at separating pressure afterwards, separation temperature is 40 DEG C
Under the conditions of separate, obtain Herba Sarcandrae extract；
Taking the Herba Ephedrae coarse granule of gained in step (2), adding 8 times amount volume fractions is the ethanol of 80%, returns
Stream extracts 3 times, each 1h, merges, and ethanol is reclaimed in evaporation, obtains Herba Ephedrae extract；
Take the Flos Magnoliae coarse granule of gained in step (2), at 102 DEG C, carry out vapor distillation extraction, carry
The time of taking is 16 hours, is centrifuged the oil water mixture obtained separating, and obtains Flos Magnoliae and extracts oil.
(4) weigh Borneolum Syntheticum and Venenum Bufonis according to above weight portion, use60Co irradiation sterilization mode to Borneolum Syntheticum and
Venenum Bufonis carries out sterilizing, and irradiation dose is 4kGy；After described Borneolum Syntheticum and Venenum Bufonis are pulverized, grain size is 60-70 μ
m。
(5) by the Herba Andrographis extract of gained in step (3), Herba Sarcandrae extract, Herba Ephedrae extract,
In Flos Magnoliae caul-fat and step (4), Borneolum Syntheticum and Venenum Bufonis after the pulverizing of gained are sufficiently mixed, and obtain mixture,
The described dehydrated alcohol of dehydrated alcohol 80 weight portion and described mixture and addition is added in described mixture
The distilled water of 8 times of gross weight, at 30 DEG C, under 100r/min rotating speed, stir 3h, re-use 150 mesh
Filter screen filtration, is distributed into the filtrate obtained in nose spray bottle, to obtain final product.
Embodiment 2
A kind of spray snot, the raw material components of employing includes:
Herba Andrographis 40 weight portion, Herba Sarcandrae 60 weight portion, Borneolum Syntheticum 1 weight portion, Flos Magnoliae 30 weight portion,
Herba Ephedrae 0.2 weight portion, Venenum Bufonis 0.5 weight portion.
The preparation method of the above spray snot, comprises the following steps:
(1) weigh Herba Andrographis, Herba Sarcandrae, Flos Magnoliae and Herba Ephedrae according to above weight portion, use moist heat sterilization
Method carries out sterilizing to above raw material, and sterilising temp is 121 DEG C, and sterilization time is 30min；
(2) each raw material components after the sterilizing of gained in step (1) is respectively placed in drying baker,
Under the conditions of 75 DEG C, it is separately dried 8 hours；Again above each raw material components is pulverized respectively, sieve, worn
Heart lotus coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and Herba Ephedrae coarse granule, the above is coarse grained
Particle size is 20-80 mesh；
(3) the Herba Andrographis coarse granule of gained in step (2) is put in supercritical extraction tank, seal,
The flow of carbon dioxide is 2Kg/h, and extraction temperature is 60 DEG C, and extracting pressure is to carry out under conditions of 35MPa
Carbon dioxide supercritical fluid extraction, extraction time is 3h；Being 8MPa at separating pressure afterwards, separation temperature is
Separate under conditions of 45 DEG C, obtain Herba Andrographis extract；
The Herba Sarcandrae coarse granule of gained in step (2) is put in supercritical extraction tank, seals, in titanium dioxide
The flow of carbon is 10Kg/h, and extraction temperature is 58 DEG C, and extracting pressure is to carry out dioxy under conditions of 32MPa
Changing carbon supercritical extraction, extraction time is 2h；Being 10MPa at separating pressure afterwards, separation temperature is 35 DEG C
Under conditions of separate, obtain Herba Sarcandrae extract；
Taking the Herba Ephedrae coarse granule of gained in step (2), adding 8 times amount volume fractions is the ethanol of 80%, returns
Stream extracts 2 times, each 2h, merges, and ethanol is reclaimed in evaporation, obtains Herba Ephedrae extract；
Take the Flos Magnoliae coarse granule of gained in step (2), at 108 DEG C, carry out vapor distillation extraction, carry
The time of taking is 12 hours, is centrifuged the oil water mixture obtained separating, and obtains Flos Magnoliae and extracts oil.
(4) weigh Borneolum Syntheticum and Venenum Bufonis according to above weight portion, use60Co irradiation sterilization mode to Borneolum Syntheticum and
Venenum Bufonis carries out sterilizing, and irradiation dose is 5kGy；After described Borneolum Syntheticum and Venenum Bufonis are pulverized, grain size is 90-100
μm。
(5) by the Herba Andrographis extract of gained in step (3), Herba Sarcandrae extract, Herba Ephedrae extract,
In Flos Magnoliae caul-fat and step (4), Borneolum Syntheticum and Venenum Bufonis after the pulverizing of gained are sufficiently mixed, and obtain mixture,
The described dehydrated alcohol of dehydrated alcohol 100 weight portion and described mixture and addition is added in described mixture
The distilled water of 8 times of gross weight, at 40 DEG C, under 150r/min rotating speed, stir 1 hour, re-use 150
Mesh filter screen filtration, is distributed into the filtrate obtained in nose spray bottle, to obtain final product.
Embodiment 3
A kind of spray snot, the raw material components of employing includes:
Herba Andrographis 60 weight portion, Herba Sarcandrae 30 weight portion, Borneolum Syntheticum 2 weight portion, Flos Magnoliae 20 weight portion,
Herba Ephedrae 1.2 weight portion, Venenum Bufonis 0.9 weight portion.
The preparation method of the above spray snot, comprises the following steps:
(1) weigh Herba Andrographis, Herba Sarcandrae, Flos Magnoliae and Herba Ephedrae according to above weight portion, use moist heat sterilization
Method carries out sterilizing to above raw material, and sterilising temp is 121 DEG C, and sterilization time is 30min；
(2) each raw material components after the sterilizing of gained in step (1) is respectively placed in drying baker,
Under the conditions of 80 DEG C, it is separately dried 7 hours；Again above each raw material components is pulverized respectively, sieve, worn
Heart lotus coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and Herba Ephedrae coarse granule, the above is coarse grained
Particle size is 20-80 mesh；
(3) the Herba Andrographis coarse granule of gained in step (2) is put in supercritical extraction tank, seal,
The flow of carbon dioxide is 10Kg/h, and extraction temperature is 50 DEG C, and extracting pressure is to enter under conditions of 25MPa
Row carbon dioxide supercritical fluid extraction, extraction time is 2h；It is 6MPa at separating pressure afterwards, separation temperature
Separate under conditions of being 42 DEG C, obtain Herba Andrographis extract；
The Herba Sarcandrae coarse granule of gained in step (2) is put in supercritical extraction tank, seals, in titanium dioxide
The flow of carbon is 15Kg/h, and extraction temperature is 65 DEG C, and extracting pressure is to carry out dioxy under conditions of 40MPa
Changing carbon supercritical extraction, extraction time is 3h；Being 8MPa at separating pressure afterwards, separation temperature is 30 DEG C
Under conditions of separate, obtain Herba Sarcandrae extract；
Taking the Herba Ephedrae coarse granule of gained in step (2), adding 8 times amount volume fractions is the ethanol of 80%, returns
Stream extracts 3 times, each 1.5h, merges, and ethanol is reclaimed in evaporation, obtains Herba Ephedrae extract；
Take the Flos Magnoliae coarse granule of gained in step (2), at 105 DEG C, carry out vapor distillation extraction, carry
The time of taking is 15 hours, is centrifuged the oil water mixture obtained separating, and obtains Flos Magnoliae and extracts oil.
(4) weigh Borneolum Syntheticum and Venenum Bufonis according to above weight portion, use60Co irradiation sterilization mode to Borneolum Syntheticum and
Venenum Bufonis carries out sterilizing, and irradiation dose is 6kGy；After described Borneolum Syntheticum and Venenum Bufonis are pulverized, grain size is 60-70 μ
m。
(5) by the Herba Andrographis extract of gained in step (3), Herba Sarcandrae extract, Herba Ephedrae extract,
In Flos Magnoliae caul-fat and step (4), Borneolum Syntheticum and Venenum Bufonis after the pulverizing of gained are sufficiently mixed, and obtain mixture,
The described dehydrated alcohol of dehydrated alcohol 150 weight portion and described mixture and addition is added in described mixture
The distilled water of 8 times of gross weight, at 38 DEG C, under 200r/min rotating speed, stir 1 hour, re-use 200
Mesh filter screen filtration, is distributed into the filtrate obtained in nose spray bottle, to obtain final product.
Embodiment 4
A kind of spray snot, the raw material components of employing includes:
Herba Andrographis 10 weight portion, Herba Sarcandrae 12 weight portion, Borneolum Syntheticum 0.2 weight portion, Flos Magnoliae 6 weight portion,
Herba Ephedrae 0.2 weight portion, Venenum Bufonis 0.2 weight portion.
The preparation method of the above spray snot, comprises the following steps:
(1) weigh Herba Andrographis, Herba Sarcandrae, Flos Magnoliae and Herba Ephedrae according to above weight portion, use moist heat sterilization
Method carries out sterilizing to above raw material, and sterilising temp is 121 DEG C, and sterilization time is 30min；
(2) each raw material components after the sterilizing of gained in step (1) is respectively placed in drying baker,
Under the conditions of 74 DEG C, it is separately dried 8 hours；Again above each raw material components is pulverized respectively, sieve, worn
Heart lotus coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and Herba Ephedrae coarse granule, the above is coarse grained
Particle size is 20-80 mesh；
(3) the Herba Andrographis coarse granule of gained in step (2) is put in supercritical extraction tank, seal,
The flow of carbon dioxide is 8Kg/h, and extraction temperature is 55 DEG C, and extracting pressure is to carry out under conditions of 25MPa
Carbon dioxide supercritical fluid extraction, extraction time is 2h；Being 6MPa at separating pressure afterwards, separation temperature is
Separate under conditions of 40 DEG C, obtain Herba Andrographis extract；
The Herba Sarcandrae coarse granule of gained in step (2) is put in supercritical extraction tank, seals, in titanium dioxide
The flow of carbon is 10Kg/h, and extraction temperature is 55 DEG C, and extracting pressure is to carry out dioxy under conditions of 35MPa
Changing carbon supercritical extraction, extraction time is 3h；Being 8MPa at separating pressure afterwards, separation temperature is 35 DEG C
Under conditions of separate, obtain Herba Sarcandrae extract；
Taking the Herba Ephedrae coarse granule of gained in step (2), adding 8 times amount volume fractions is the ethanol of 80%, returns
Stream extracts 3 times, each 1h, merges, and ethanol is reclaimed in evaporation, obtains Herba Ephedrae extract；
Take the Flos Magnoliae coarse granule of gained in step (2), at 106 DEG C, carry out vapor distillation extraction, carry
The time of taking is 14 hours, is centrifuged the oil water mixture obtained separating, and obtains Flos Magnoliae and extracts oil.
(4) weigh Borneolum Syntheticum and Venenum Bufonis according to above weight portion, use60Co irradiation sterilization mode to Borneolum Syntheticum and
Venenum Bufonis carries out sterilizing, and irradiation dose is 6kGy；After described Borneolum Syntheticum and Venenum Bufonis are pulverized, grain size is 50-60 μ
m。
(5) by the Herba Andrographis extract of gained in step (3), Herba Sarcandrae extract, Herba Ephedrae extract,
In Flos Magnoliae caul-fat and step (4), Borneolum Syntheticum and Venenum Bufonis after the pulverizing of gained are sufficiently mixed, and obtain mixture,
The described dehydrated alcohol of dehydrated alcohol 100 weight portion and described mixture and addition is added in described mixture
The distilled water of 8 times of gross weight, at 35 DEG C, under 150r/min rotating speed, stir 3 hours, re-use 150
Mesh filter screen filtration, is distributed into the filtrate obtained in nose spray bottle, to obtain final product.
The therapeutic effect of the present invention, is illustrated by following clinical case.
The present inventor is carried out by the effect after clinical 200 example rhinitis patients are used spray snot of the present invention
Observe, the maleest 91 examples, female 109 example, minimum 15 years old of age, maximum 70 years old, acute rhinitis 62
Example, chronic rhinitis 82 example, allergic rhinitis 56 example.The most each case carries out 1-3 respectively according to practical situation
The medication of the course for the treatment of, obtains following result.
Efficacy assessment standard:
Cure: clinical symptoms is wholly absent, recover example orthobiosis 191.
Effective: clinical symptoms partial disappearance, nasal cavity inflammation has taken a turn for the better 9 examples.
Invalid: symptom and sign is not improved 0 example.Cure rate reaches 95.5%, and total effective rate reaches 100%.
Typical clinical case one:
Wang, female, 15 years old, suffer from acute rhinitis, there is nasal obstruction, stream clear water sample nasal mucus and frequent sneeze
Clinical symptoms.Use the described spray snot after one week treatment provided in the embodiment of the present invention 1, symptom of having a stuffy nose
Alleviating, after using a course for the treatment of, clinical symptoms is wholly absent.
Typical clinical case two:
Liao so-and-so, man, 42 years old, suffer from chronic rhinitis, there is nasal obstruction for a long time, tympanum external drum and resorption are told
The symptoms such as expectorant, after using the described spray snot provided in the embodiment of the present invention 2 to treat a course for the treatment of, nasal cavity leads to
Vaporous condition is obviously improved, and nasal cavity secretions reduces, and after being continuing with a course for the treatment of, clinical symptoms disappears completely
Lose.
Typical clinical case three:
Liu, man, 62 years old, suffer from allergic rhinitis for many years, when changing according to the season, especially to replace season easy in Winter-Spring
Morbidity, has that eyes are rubescent, itches, sheds tears, and nasal secretion is many, frequent sneeze, and under olfactory sensation
Degradation symptom, this patient uses the described spray provided in the embodiment of the present invention 3 between allergic rhinitis stage of attack
Snot, after treating a course for the treatment of, the symptom of frequent sneeze alleviates, and nasal secretion reduces, nasal airflow
Situation is improved, and after two courses for the treatment of of continual cure, clinical symptoms is wholly absent.
Typical clinical case four:
Huang, female, 31 years old, suffer from chronic sinusitis for many years, nasal obstruction is serious, rhinorrhea, with feeling sick
Headache syndromes, after using the described spray snot provided in the embodiment of the present invention 4 to treat a course for the treatment of, nasal cavity leads to
Vaporous condition improve, purulent secretion reduce, be continuing with described spray snot treatment two courses for the treatment of after, clinical condition
Shape is wholly absent.
The present invention is not limited to above-mentioned preferred forms, and anyone can draw it under the enlightenment of the present invention
His various forms of products, no matter but in its shape or structure, make any change, every have and the application
Technical scheme as same or like, within all falling within protection scope of the present invention.
Claims (9)
1. a spray snot, it is characterised in that the raw material components of employing includes:
Herba Andrographis 10-60 weight portion, Herba Sarcandrae 10-60 weight portion, Borneolum Syntheticum 0.2-3 weight portion, Flos Magnoliae 5-30
Weight portion, Herba Ephedrae 0.2-1.2 weight portion, Venenum Bufonis 0.2-0.9 weight portion.
Spray snot the most according to claim 1, it is characterised in that the raw material components of employing includes:
Herba Andrographis 10-20 weight portion, Herba Sarcandrae 10-20 weight portion, Borneolum Syntheticum 0.2-1 weight portion, Flos Magnoliae 5-10
Weight portion, Herba Ephedrae 0.2-0.4 weight portion, Venenum Bufonis 0.2-0.3 weight portion.
Spray snot the most according to claim 1, it is characterised in that the raw material components of employing includes:
Herba Andrographis 10 weight portion, Herba Sarcandrae 12 weight portion, Borneolum Syntheticum 0.2 weight portion, Flos Magnoliae 6 weight portion,
Herba Ephedrae 0.2 weight portion, Venenum Bufonis 0.2 weight portion.
4. the preparation method of the spray snot according to any one of claim 1-3, it is characterised in that bag
Include following steps:
(1) Herba Andrographis, Herba Sarcandrae, Flos Magnoliae and Herba Ephedrae, sterilizing are weighed according to above weight portion；
(2) each raw material components after the sterilizing of gained in step (1) is separately dried, pulverizes, sieve,
Obtain Herba Andrographis coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and Herba Ephedrae coarse granule；
(3) the Herba Andrographis coarse granule of gained in step (2) is put in supercritical extraction tank, seal, fill
Enter carbon dioxide, extract, separate, obtain Herba Andrographis extract；
The Herba Sarcandrae coarse granule of gained in step (2) is put in supercritical extraction tank, seals, be filled with dioxy
Change carbon, extract, separate, obtain Herba Sarcandrae extract；
Take the Herba Ephedrae coarse granule of gained in step (2), carry out alcohol reflux, obtain Herba Ephedrae extract；
Take the Flos Magnoliae coarse granule of gained in step (2), carry out vapor distillation extraction, obtain Flos Magnoliae and carry
Take oil；
(4) weigh Borneolum Syntheticum and Venenum Bufonis, sterilizing according to above weight portion, pulverize standby；
(5) by the Herba Andrographis extract of gained in step (3), Herba Sarcandrae extract, Herba Ephedrae extract,
In Flos Magnoliae caul-fat and step (4), Borneolum Syntheticum and Venenum Bufonis after the pulverizing of gained are sufficiently mixed, and are mixed
Thing, adds dehydrated alcohol and distilled water in described mixture, is sufficiently mixed, filter, subpackage, obtain institute
State spray snot.
The preparation method of spray snot the most according to claim 4, it is characterised in that in step (1)
The sterilizing methods used is moist hear heat test, and the sterilising temp of described moist hear heat test is 121 DEG C, during sterilizing
Between be 30min.
The preparation method of spray snot the most according to claim 4, it is characterised in that in step (2)
Being dried each raw material components of gained in step (1), baking temperature is 70-80 DEG C, and drying time is
6-8 hour；After pulverizing and sieving, gained Herba Andrographis coarse granule, Herba Sarcandrae coarse granule, Flos Magnoliae coarse granule and fiber crops
Yellow coarse grained particle size is 20-80 mesh.
The preparation method of spray snot the most according to claim 4, it is characterised in that in step (3)
When described Herba Andrographis coarse granule is carried out supercritical extraction, the flow using carbon dioxide is 2-10Kg/h, extraction
Taking temperature and be 45-60 DEG C, extraction time is 2-3h, and extracting pressure is 25-35MPa, and separating pressure is 4-8MPa,
Separation temperature is 40-45 DEG C；
When described Herba Sarcandrae coarse granule is carried out supercritical extraction, the flow of the carbon dioxide of employing is
4-15Kg/h, extraction temperature is 50-65 DEG C, and extraction time is 2-3h, and extracting pressure is 25-40MPa, point
Tripping power is 5-10MPa, and separation temperature is 30-40 DEG C；
When described Herba Ephedrae coarse granule is carried out alcohol reflux, in described Herba Ephedrae coarse granule, add 8-10 times
Amount volume fraction is the ethanol of 80%, reflux, extract, 2-3 time, and each 1-2h merges, and ethanol is reclaimed in evaporation,
Obtain described Herba Ephedrae extract；
When described Flos Magnoliae coarse granule carries out vapor distillation extraction, Extracting temperature is 102-108 DEG C, extracts
Time is 12-16h, and the oil water mixture obtained after being condensed by product of distillation is separated by centrifugation, obtains
Flos Magnoliae extracts oil.
The preparation method of spray snot the most according to claim 4, it is characterised in that in step (4)
Use60Co irradiation sterilization mode carries out sterilizing to Borneolum Syntheticum and Venenum Bufonis, and irradiation dose is 4-6kGy；Described Borneolum Syntheticum
After pulverizing with Venenum Bufonis, grain size is 50-100 μm.
The preparation method of spray snot the most according to claim 4, it is characterised in that in step (5)
The amount adding dehydrated alcohol is 80-150 weight portion, adds the institute that amount is described mixture and addition of distilled water
State 8 times of gross weight of dehydrated alcohol；Use intensification alr mode by described mixture mix homogeneously, stirring
Rotating speed is 100-200r/min, and whipping temp is 30-40 DEG C, and mixing time is 1-3h；Filter the filter screen used
Aperture size is 150-200 mesh.
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| CN201610231398.9A CN105770002A (en) | 2016-04-14 | 2016-04-14 | Nose spraying water and preparing method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481471A (en) * | 2019-01-25 | 2019-03-19 | 上海真仁堂药业有限公司 | The preparation method of dried venom of toads powder medicine materical crude slice |
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|---|---|---|---|---|
| CN1493351A (en) * | 2003-09-18 | 2004-05-05 | 江苏扬子江药业集团有限公司 | Chinese medicine compound spraying agent for treating acute, chronic nasitis and its preparation method |
| CN101972313A (en) * | 2010-09-29 | 2011-02-16 | 王矛 | Medicament for treating rhinitis |
| CN103251709A (en) * | 2013-05-27 | 2013-08-21 | 丁念善 | External medicine nose through paste for treating rhinitis and preparation method thereof |
| CN105287926A (en) * | 2014-07-05 | 2016-02-03 | 于飞 | Traditional Chinese herb pillow for treating rhinitis |
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2016
- 2016-04-14 CN CN201610231398.9A patent/CN105770002A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1493351A (en) * | 2003-09-18 | 2004-05-05 | 江苏扬子江药业集团有限公司 | Chinese medicine compound spraying agent for treating acute, chronic nasitis and its preparation method |
| CN101972313A (en) * | 2010-09-29 | 2011-02-16 | 王矛 | Medicament for treating rhinitis |
| CN103251709A (en) * | 2013-05-27 | 2013-08-21 | 丁念善 | External medicine nose through paste for treating rhinitis and preparation method thereof |
| CN105287926A (en) * | 2014-07-05 | 2016-02-03 | 于飞 | Traditional Chinese herb pillow for treating rhinitis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109481471A (en) * | 2019-01-25 | 2019-03-19 | 上海真仁堂药业有限公司 | The preparation method of dried venom of toads powder medicine materical crude slice |
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Application publication date: 20160720 |