CN111575142A - Preparation method of functional dendrobe wine for improving yin nourishing and deficiency tonifying - Google Patents
Preparation method of functional dendrobe wine for improving yin nourishing and deficiency tonifying Download PDFInfo
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- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
- C12G3/05—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention discloses a preparation method and application of a functional dendrobium wine for improving yin nourishing and deficiency tonifying, which is prepared by taking white spirit as base wine and Chinese medicinal materials, wherein the Chinese medicinal materials comprise 15 Chinese medicinal materials such as dendrobium huoshanense, cistanche, American ginseng, epimedium herb, medlar, prepared rehmannia root, dogwood fruit, eucommia bark, Chinese taxillus twig, oriental waterplantain rhizome, cinnamon, semen allii tuberosi, hippocampus, pilose antler, liquorice and the like. The preparation method comprises pulverizing herba Dendrobii into fine powder, parching with other 14 kinds of Chinese medicinal materials with refined salt powder, adding Chinese liquor, mixing, soaking, and filtering to obtain liquor; adding the Chinese liquor again, soaking, filtering to obtain filtrate, mixing the two filtrates, and blending to appropriate alcohol content; the dendrobium huoshanense wine has the effects of warming kidney and suppressing yang, tonifying qi and securing essence, and building body, and has good curative effects on hyposexuality, cold and weakness of essence, soreness and weakness of waist and legs, dysphoria and insomnia, chronic prostatitis and the like caused by kidney yang deficiency and hyperactivity, qi deficiency and blood weakness.
Description
Technical Field
The invention relates to a medicated diet, in particular to a functional dendrobium wine for improving human immunity.
Background
The traditional Chinese medicine considers that the food and the food are homologous, and the diet and the health are closely related. Therefore, the health preserving science of traditional Chinese medicine is not weak for thousands of years, especially at present of rapid development of science and technology, the drug resistance of human body to bacteria and viruses generated by abuse of western medicines cannot control the disease condition, and the medicine residue also seriously pollutes the environment and harms the health of the human body, so that at present, people call to return to the nature, look for green food without residue, and medical workers try to search animal and Chinese herbal medicine regulators capable of enhancing the immunity of the human body from natural animals and plants to prevent and treat the common and multiple diseases. The food is eaten by people as days, the food therapy and the food nourishing are important parts of the health preserving science of the traditional Chinese medicine, so that the importance of the medicated food is clearly shown, namely the three-element disease is nourished by seven elements, and the medicine nourishing is not like the food nourishing. China is the origin of Chinese herbal medicine and medicated diet therapy, and has no shortage of Chinese herbal medicine for resisting germs and viruses and medicated diet for preserving health and improving human immunity.
Health is a basic stone for harmonious life, and the body is the original money for good life. In modern society, due to the rapid pace of life, especially, the great pressure of work and life for a long time for men, the spirit is in a high tension, and many people are in a sub-health state more or less, so that the sexual life time of men is shortened, the sexual indifference of women is caused, and certain damage is brought to the men and the families.
Sexual dysfunction in sub-health state involves endocrine or nervous system disorder, but is different from sexual dysfunction of organic nature, usually manifested as hyposexuality, soft erection, and no orgasm, and seriously results in cold sperm and sterility, thereby affecting family harmony and stability. From the perspective of traditional Chinese medicine, the reasons for the symptoms are mainly indicated as kidney-yang deficiency, hypofunction and yin deficiency with smooth essence. In Western medicine, hormone medicines are mostly adopted, so that the symptoms and root causes are generally treated, and the disease is easy to recur after the medicine is stopped. Along with the improvement of living standard of people, more and more attention is paid to health problems, and nontoxic medicines for warming kidney and suppressing yang, building body and delaying senility are discovered from traditional Chinese medicines and become a hotspot of research.
The wine is a good solvent, modern scientific experiments show that most of the active ingredients in the traditional Chinese medicinal materials can be dissolved in the wine, and the wine has the antiseptic effect, can prevent the putrefaction of the active ingredients and improve the stability of the drug effect. The medicinal liquor is prepared by dissolving traditional Chinese medicines for strengthening body constitution and liquor into a whole, wherein various effective components of the traditional Chinese medicines are dissolved, and the effects of the traditional Chinese medicines are fully exerted by the aid of the liquor power and the liquor. Effective components of traditional Chinese medicinal materials such as dendrobium huoshanense and the like can be separated out by soaking in white spirit, so that the effects of warming and recuperating kidney yang, nourishing yin and blood, prolonging life and beautifying are achieved.
Disclosure of Invention
The invention aims to develop a functional traditional Chinese medicine wine which can improve the immunity of human body, promote the recovery of weak body and treat chronic diseases caused by yin-yang disharmony at present according to the basic theory and the principle of treatment based on syndrome differentiation of traditional Chinese medicine. The invention is a medicated wine for dietetic therapy, which is prepared by combining rare traditional Chinese medicines such as dendrobium huoshanense, cistanche salsa, American ginseng, epimedium, medlar, prepared rehmannia root, dogwood fruit, eucommia bark, Chinese taxillus twig, alisma orientale, largehead atractylodes rhizome, Chinese chive seed, sea horse, pilose antler, liquorice and the like through a special process, and has the functions of protecting the liver and strengthening the spleen, nourishing yin and suppressing yang, enriching the blood and tonifying qi, promoting the production of body fluid and moistening dryness and treating kidney deficiency type prostate diseases. The traditional Chinese medicinal materials in the formula are combined, and the effective components of the medicines generate synergistic effect through the extraction function of alcohol, so that the traditional Chinese medicinal composition can effectively improve the immunity of a human body, promote the recovery of the organism and treat some chronic diseases with imbalance of yin and yang. The medicinal liquor prescription takes rare Chinese herbal medicine dendrobium huoshanense as monarch drug, the dendrobium huoshanense is also called as dendrobium huoshanense, is an extreme product in dendrobium huoshanense, is slightly cold in nature, sweet and light in taste, can clear heat and promote fluid production, nourish liver and lung, stimulate the appetite and invigorate the spleen, replenish vital essence and strengthen yin, promote fluid production to quench thirst, tonify deficiency and win, and remove deficiency fire in stomach; the medicine has the effects of greatly supplementing yin deficiency, has good effects of nourishing yin and clearing heat, strengthening liver, nourishing lung and tonifying kidney in the late stage and recovery period of consumptive disease blood loss, hemoptysis, intestinal wind blood hemorrhoid, night sweat, summer heat, heat disease and tuberculosis, and has obvious curative effects and repairing effects on hyperpyrexia, viscera strain and weakness after diseases; cistanchis herba, sweet, salty and warm, enters kidney and large intestine meridians. Tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation. Can be used for treating sexual impotence, infertility, soreness of waist and knees, weakness of tendons and bones, constipation due to intestinal dryness; american ginseng, sweet, slightly bitter and cool. It enters heart, lung and kidney meridians. Tonify qi, nourish yin, clear heat and promote fluid production. Can be used for treating deficiency of vital energy and yin, internal heat, cough, asthma, phlegm, asthenia, vexation, fatigue, diabetes, xerostomia, dry throat, fatigue, oxidation and stress, inhibiting platelet aggregation, and reducing blood coagulability; epimedium herb, pungent and sweet in flavor, warm in nature, enters liver and kidney meridians. Tonify kidney yang, strengthen tendons and bones, dispel wind-damp. Can be used for treating sexual impotence, spermatorrhea, tendons and bones flaccidity, rheumatalgia, numbness and contracture; gou Qi Zi is sweet and neutral, and enters liver and kidney meridians. Nourishing liver and kidney, replenishing vital essence to improve eyesight, consumptive disease and essence deficiency, soreness and pain of waist and knees, dizziness and tinnitus, impotence and spermatorrhea, internal heat and diabetes, and is a common medicine for beautifying and enhancing immunity in the traditional Chinese medicinal materials; shu Di Huang is sweet in flavor and warm in nature, and enters liver and kidney meridians. Enriching blood and moistening; replenishing vital essence and marrow; dogwood fruit, fructus Corni, sour and astringent, warm slightly, enters liver and kidney meridians. Tonifying liver and kidney, arresting seminal emission and relieving depletion; du Zhong is sweet and warm. Enter liver and kidney meridians, tonify liver and kidney, strengthen waist and knee joints, strengthen tendons and bones; sang Ji Sheng, bitter, sweet and even enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, dispel wind-damp; alisma orientale, sweet and light in flavor; cold in nature, entering kidney and bladder meridians, promoting diuresis and excreting dampness; clearing heat and treating stranguria; cinnamon is hot in nature, pungent and sweet in flavor, enters kidney, spleen, heart and liver channels, tonifies fire, strengthens yang, guides fire to source, dispels cold, relieves pain, activates blood and promotes menstruation; semen allii tuberosi, pungent in nature, sweet in flavor, warm in nature, entering kidney and liver meridians, warming and nourishing liver and kidney, tonifying yang and securing essence, and warming waist and knee joints; hippocampus, sweet and warm, enters liver and kidney meridians. Strengthening body constitution, invigorating kidney, supporting yang, relaxing muscles and tendons, activating collateral flow, relieving inflammation and pain, tranquilizing mind; pilose antler is sweet, salty and warm, enters kidney and liver meridians, strengthens kidney yang, benefits essence and blood and strengthens muscles and bones; the liquorice has sweet taste and mild nature, enters heart, lung, spleen and stomach channels, tonifies spleen and qi, clears heat and toxic materials, eliminates phlegm and stops coughing. The rare medicines are combined with the white spirit, can be organically matched, and have the effects of clearing heat and purging fire, cooling blood and removing toxicity, resisting bacteria and diminishing inflammation and improving the immunity of the organism together so as to achieve the effects of epidemic prevention, disease control and rehabilitation. The medicinal liquor preparation has strict matching, and has no incompatibility of eighteen antagonisms and nineteen incompatibilities, and experiments also prove that the prescription is a safe and non-toxic preparation, has sweet taste and no bitter and astringent taste, and is very suitable for the taste of consumers.
The adopted traditional Chinese medicines also comprise a rape flower extract, the camellia has a long history of preventing and treating diseases in folks of China, the medicinal value of the camellia has been recorded in Ben Cao gang mu of Li Shizhen of Ming Dynasty for a long time, and the medicinal value of the camellia has been detailed in Ben Cao Shi Xin of Wu Yilo of Qing Qianlong famous medical science for clearing away heat and toxic materials, stopping bleeding, removing blood stasis and reducing swelling, tonifying kidney and strengthening yang, and preventing and treating diabetes, neurasthenia, cardiovascular diseases and the like. Modern research and analysis prove that the camellia contains rich nutrient components such as protein, amino acid, polyphenol, polysaccharide, anthocyanin, flavone, vitamin C, various trace mineral elements and the like.
The solvent extraction method is the main extraction process of the effective components of the Chinese herbal medicines at present, but different solvents have different solubilities of the effective components in the Chinese herbal medicines, the effective components extracted by different solvents can be different, and the different solvent extraction processes of the effective components in the camellia oleifera flowers are rarely reported at home and abroad.
In order to solve the technical problems, the invention adopts the technical scheme that:
a functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following traditional Chinese medicinal materials: herba Dendrobii, Cistanchis herba, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, Corni fructus, Eucommiae cortex, herba Taxilli, Alismatis rhizoma, Atractylodis rhizoma, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and Glycyrrhrizae radix.
Preferably, the functional dendrobium wine comprises the following Chinese medicinal materials: 20-40g of dendrobium huoshanense, 20-40g of cistanche, 35-55g of American ginseng, 10-30g of epimedium herb, 35-55g of medlar, 30-50g of prepared rehmannia root, 10-30g of cornus officinalis, 5-15g of eucommia bark, 5-15g of parasitic loranthus, 5-15g of rhizoma alismatis, 5-15g of red soil fried bighead atractylodes rhizome, 3-8g of semen allii tuberosi, 6-10g of hippocampus, 2-8g of pilose antler and 2-8g of liquorice.
More preferably, the functional dendrobium wine comprises the following Chinese medicinal materials: 30g of dendrobium huoshanense, 30g of cistanche, 45g of American ginseng, 20g of epimedium herb, 45g of medlar, 40g of prepared rehmannia root, 20g of cornus officinalis, 10g of eucommia bark, 10g of loranthus parasiticus, 10g of rhizoma alismatis, 10g of bighead atractylodes rhizome fried by red soil, 5g of semen allii tuberosi, 8g of hippocampus, 5g of cornua cervi pantotrichum and 5g of liquorice.
The invention also aims to provide a preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying.
A preparation method of a functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following steps:
s1, crushing the dendrobium huoshanense into powder of 60-100 meshes for later use;
s2 cleaning herba cistanches, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, fructus Corni, cortex Eucommiae, herba Taxilli, rhizoma Alismatis, rhizoma Atractylodis Macrocephalae, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and radix Glycyrrhizae;
s3, dissolving 10-30g of fine powder iodine salt in 50-70mL of water at 90-100 ℃ for later use;
s4, burning the iron pan to red, then putting the cleaned traditional Chinese medicinal materials obtained in the step S2 and the refined powder iodine salt aqueous solution obtained in the step S3 into the pan in sequence, and immediately stir-frying until the materials turn brown;
s5, simultaneously putting the dendrobium huoshanense powder obtained in the step S1 and the scorched traditional Chinese medicine beverage obtained in the step S4 into a wine jar, adding the white wine for soaking for the first time, stirring for 1 time every 18-24 hours, soaking for 10-15 days, and filtering out the wine. Adding Chinese liquor for the second time, soaking for more than 10-12 days, stirring for 1 time every 18-24 hr, filtering to obtain liquor, and mixing the liquor;
s6, adding 40-60g of honey into 80-120mL of water at 40-60 ℃, decocting the honey into thick soup in an iron pan with slow fire, and adding the thick soup into the wine liquid to be uniformly stirred;
s7 blending the wine with sterile distilled water to obtain functional herba Dendrobii wine with effects of nourishing yin and tonifying deficiency.
The alcoholic strength of the white spirit for soaking is 60-65% Vol.
The first adding amount of the white spirit for soaking is 6-10 times of the total weight of the traditional Chinese medicinal materials, and the second adding amount of the white spirit for soaking is 3-7 times of the total weight of the traditional Chinese medicinal materials.
The alcohol content of the functional dendrobe wine prepared by blending the dendrobe wine for nourishing yin and tonifying deficiency is 38-48% Vol.
The invention also adopts another technical scheme that:
a functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following traditional Chinese medicinal materials: 20-40g of dendrobium huoshanense, 20-40g of cistanche, 35-55g of American ginseng, 10-30g of epimedium herb, 35-55g of medlar, 30-50g of prepared rehmannia root, 10-30g of cornus officinalis, 5-15g of eucommia bark, 5-15g of parasitic loranthus, 5-15g of rhizoma alismatis, 5-15g of red soil fried bighead atractylodes rhizome, 3-8g of Chinese chive seed, 6-10g of sea horse, 2-8g of pilose antler, 2-8g of liquorice and 0.5-1g of camellia extract.
The camellia oleifera flower extract is prepared by mixing one or more of camellia oleifera flower extract extracted by petroleum ether, camellia oleifera flower extract extracted by ethyl acetate and camellia oleifera flower extract extracted by n-butanol.
Preferably, the camellia oleifera flower extract is prepared by extracting camellia oleifera flower extract with petroleum ether, extracting camellia oleifera flower extract with ethyl acetate and extracting camellia oleifera flower extract with n-butanol according to a mass ratio of (1-3): (1-3): (1-3) mixing.
The preparation method of the camellia oleifera flower extract comprises the following steps:
s1, drying the camellia oleifera flowers in a 50 ℃ oven, crushing and sieving with a 60-100 mesh sieve for later use;
s2 weighing 3-5kg of dried and crushed oil-tea camellia flowers, adding 6-15L of 95% ethanol, heating, refluxing, extracting for 2-4 times, filtering, mixing filtrates, performing rotary evaporation concentration at 50-60 ℃, and evaporating to dryness in water bath to obtain oil-tea camellia flower alcohol extract;
s3 taking 100-200g of camellia oleifera flower alcohol extract, adding 200-400mL of water to disperse to prepare suspension, adding petroleum ether to extract for 3-4 times, wherein the volume ratio of each time is 1: 1 adding a solvent, combining the upper organic solvent extraction liquid each time, collecting the lower aqueous phase, performing rotary evaporation concentration at 50-60 ℃, and evaporating in a water bath to dryness to obtain an oil camellia extract extracted by petroleum ether;
s4 adding ethyl acetate into the lower aqueous phase collected after petroleum ether extraction, and extracting for 3-4 times, wherein the volume ratio of each time is 1: 1 adding a solvent, combining the upper organic solvent extraction liquid each time, collecting the lower aqueous phase, performing rotary evaporation concentration at 50-60 ℃, and evaporating in a water bath to dryness to obtain an ethyl acetate-extracted camellia oleifera extract;
s5, adding n-butanol into the lower aqueous phase collected after ethyl acetate extraction, and extracting for 3-4 times, wherein the volume ratio of each time is 1: 1 adding solvent, mixing the upper organic solvent extractive solutions, collecting the lower water phase, rotary evaporating at 50-60 deg.C for concentration, and evaporating in water bath to obtain ethyl acetate extract of Camellia oleifera flower.
Another preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following steps:
s1, crushing the dendrobium huoshanense into powder of 60-100 meshes for later use;
s2 cleaning herba cistanches, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, fructus Corni, cortex Eucommiae, herba Taxilli, rhizoma Alismatis, rhizoma Atractylodis Macrocephalae, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and radix Glycyrrhizae;
s3, dissolving 10-30g of fine powder iodine salt in 50-70mL of water at 90-100 ℃ for later use;
s4, burning the iron pan to red, then putting the cleaned traditional Chinese medicinal materials obtained in the step S2 and the refined powder iodine salt aqueous solution obtained in the step S3 into the pan in sequence, and immediately stir-frying until the materials turn brown;
s5, simultaneously putting the dendrobium huoshanense powder obtained in the step S1, the scorched traditional Chinese medicine beverage obtained in the step S4 and the camellia oleifera flower extract into a wine jar, adding white wine for soaking for the first time, stirring for 1 time every 18-24 hours, filtering out wine liquid after soaking for 10-15 days, adding white wine for soaking for the second time, stirring for 1 time every 18-24 hours, continuously soaking for more than 10-12 days, filtering out wine liquid, and combining the wine liquid obtained in the two times;
s6, adding 40-60g of honey into 80-120mL of water at 40-60 ℃, decocting the honey into thick soup in an iron pan with slow fire, and adding the thick soup into the wine liquid to be uniformly stirred;
s7 blending the wine with sterile distilled water to obtain functional herba Dendrobii wine with effects of nourishing yin and tonifying deficiency.
The alcoholic strength of the white spirit for soaking is 60-65% Vol.
The first adding amount of the white spirit for soaking is 6-10 times of the total weight of the traditional Chinese medicinal materials, and the second adding amount of the white spirit for soaking is 3-7 times of the total weight of the traditional Chinese medicinal materials.
The alcohol content of the functional dendrobe wine prepared by blending the dendrobe wine for nourishing yin and tonifying deficiency is 38-48% Vol.
The invention has the beneficial effects that:
the functional dendrobe wine for nourishing yin and tonifying deficiency is orange yellow and transparent in wine color, strong in medicine fragrance, soft and mellow, has good effects of harmonizing yin and yang, nourishing qi and blood, prolonging life and beautifying after long-term drinking, has the effects of warming and tonifying kidney yang, tonifying qi and producing sperm, delaying senescence, enhancing immunity and the like, and has good curative effects on hyposexuality, cold and weakness, soreness and weakness of waist and legs, dysphoria and insomnia and the like caused by deficiency of kidney yang and deficiency of qi and blood.
According to the dendrobium wine, another technical scheme is adopted, and the camellia oleifera flower extract is added into the functional dendrobium wine for nourishing yin and tonifying deficiency, so that the effect of warming and invigorating kidney yang of the dendrobium wine is further improved. The preparation method of the camellia oleifera flower extract adopts three camellia oleifera flower extracts extracted by three different solvents which are obtained by petroleum ether extraction, ethyl acetate extraction and n-butanol extraction step by step, and the dendrobe wine is mixed and added, so that the effect of warming and invigorating kidney yang of the dendrobe wine is further improved.
Detailed Description
Test examples 1-5 the same functional dendrobium wine for nourishing yin and tonifying deficiency was used: the preparation method comprises the following steps: a functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following traditional Chinese medicinal materials: 30g of dendrobium huoshanense, 30g of cistanche, 45g of American ginseng, 20g of epimedium herb, 45g of medlar, 40g of prepared rehmannia root, 20g of cornus officinalis, 10g of eucommia bark, 10g of loranthus parasiticus, 10g of rhizoma alismatis, 10g of bighead atractylodes rhizome fried by red soil, 5g of semen allii tuberosi, 8g of hippocampus, 5g of cornua cervi pantotrichum and 5g of liquorice.
The preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following steps:
s1, crushing the dendrobium huoshanense into powder of 80 meshes for later use;
s2 cleaning herba cistanches, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, fructus Corni, cortex Eucommiae, herba Taxilli, rhizoma Alismatis, rhizoma Atractylodis Macrocephalae, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and radix Glycyrrhizae;
s3, dissolving 20g of fine iodine powder into 60mL of water at 100 ℃ for later use;
s4, burning the iron pan to red, then putting the cleaned traditional Chinese medicinal materials obtained in the step S2 and the refined powder iodine salt aqueous solution obtained in the step S3 into the pan in sequence, and immediately stir-frying until the materials turn brown;
s5, simultaneously putting the dendrobium huoshanense powder obtained in the step S1 and the scorched traditional Chinese medicine beverage obtained in the step S4 into a wine jar, adding the white wine for the first time for soaking, stirring for 1 time every 24 hours, and filtering out wine liquid after soaking for 15 days. Adding Chinese liquor for soaking for the second time, stirring for 1 time every 24 hr, continuously soaking for more than 12 days, filtering to obtain liquor, and mixing the liquor obtained in the two times;
s6, adding 50g of honey into 100mL of water at 50 ℃, decocting the honey into thick soup in an iron pan with slow fire, and adding the thick soup into the wine liquid to be uniformly stirred;
s7 blending the wine with sterile distilled water to obtain functional herba Dendrobii wine with effects of nourishing yin and tonifying deficiency.
The alcoholic strength of the white spirit for soaking is 60 percent Vol.
The first adding amount of the white spirit for soaking is 8 times of the total weight of the traditional Chinese medicinal materials, and the second adding amount of the white spirit for soaking is 5 times of the total weight of the traditional Chinese medicinal materials.
The alcohol content of the functional dendrobe wine prepared by the method for nourishing yin and tonifying deficiency is 48% Vol.
The prevention and treatment effects of the medicated diet on human diseases, particularly on febrile disease, diabetes and chronic disease, are further illustrated by the following test examples.
Test example 1
The chronic hepatitis B patient is accompanied by virus membrane proliferative nephritis, the functional dendrobium wine for nourishing yin and tonifying deficiency is adopted for 1 time in the morning and evening every day, 5mL of the wine is adopted for each time, the medicine is matched for consolidation treatment, according to observation and comparison, 20 cases of the functional dendrobium wine for nourishing yin and tonifying deficiency are matched by the medicine, 2 months are taken as a treatment course, 2-3 treatment courses of food therapy are adopted, in 20 cases, significant persons (symptoms disappear and urine is normal) 12 cases, 6 effective persons are included, 2 invalid persons are included, the total effective rate reaches 90%, follow-up visit is carried out for 2 years, and the curative effect is stable. Therefore, the functional dendrobium wine for nourishing yin and tonifying deficiency has good curative effect on virus membrane proliferative nephritis of chronic hepatitis B patients.
Test example 2
The functional dendrobe wine for nourishing yin and tonifying deficiency is adopted 14-20 times per week for treating impotence due to qi deficiency or sexual hypofunction, 2 months is a treatment course, and the other methods are not used during the diet therapy period. The patient is instructed to refrain from smoking, strictly refrain from drinking other white spirit, refrain from masturbation, avoid sexual intercourse and mental stress, clear heart and desire for a small amount of time, do proper exercises, and eliminate the influence of psychological factors on the disease. The food therapy result shows that the functional dendrobium wine for nourishing yin and tonifying deficiency has obvious curative effect on 86 patients with qi deficiency and impotence or low sexual function, wherein 53 patients with obvious curative effect, 18 patients with improvement and 15 patients with no effect have the total effective rate of 82 percent, and in effective cases, 28 days are the shortest patient and 56 days are the longest patient, and the patients with qi deficiency and impotence or low sexual function are treated by using medicated diet, so that the dendrobium wine has the advantages of convenient administration, good taste and no toxic or side effect, and is easy to accept by patients.
Test example 3
For chronic diabetes, the medicated diet is taken 7 times a week, and 50mL is taken one hour (20-21 o' clock) before sleep at night each time. 2 months is a treatment course, and is matched with normal insulin administration, and the diet for strictly controlling blood sugar and diabetes is adopted. And (3) dietary therapy results: after 1 treatment course of 26 patients with diabetes mellitus, 23 patients with remarkable curative effect have the average blood sugar value reduced from 12.27mmol/L (221mg) to 10.43mmol/L (188mg), 2 patients are improved, and 1 patient is ineffective, so that the total effective rate reaches 96%. Compared with the control group of diabetes patients who only adopt normal insulin administration and do not use functional dendrobium wine for nourishing yin and tonifying deficiency, the difference is very obvious.
Test example 4
The medicated diet is adopted for treating chronic prostatitis 14-20 times a week, each time is 50mL, 2 months are a treatment course, the medicated diet is matched with a common dose of diuretic and anti-inflammatory drugs, urine holding is strictly controlled, the dietary therapy result, and the functional dendrobium wine for nourishing yin and tonifying deficiency is used for 160 cases of chronic prostatitis patients, after 1 treatment course, 130 cases with obvious curative effect account for 82%, 24 cases with improvement, 6 cases with ineffectiveness, and the total effective rate reaches 96%. The frequency of getting up and drawing urine of most patients in the second night after taking the medicated diet is reduced, and the sexual desire and the physical strength can be gradually recovered, so that the curative effect of treating the chronic prostatitis is very obvious.
Test example 5
The medicated diet is adopted 14 times a week, 2 months are a treatment course, the medicated diet is matched with traditional Chinese medicine decoction such as houttuynia cordata, selfheal, bulbus fritilariae and radix asparagi to treat the pulmonary tuberculosis, the result of the dietary therapy is that the functional dendrobe wine for nourishing yin and tonifying deficiency has 42 cases of patients with the pulmonary tuberculosis, after 1 treatment course, 32 cases with obvious curative effect account for 76 percent, 6 cases are improved, 4 cases are invalid, and the total effective rate reaches 90 percent. Most patients can get better and recover gradually in different degrees after taking the medicated diet for half a month, and the symptoms of fever, night sweat, cough, asthma, hemoptysis, anorexia and the like are improved, so that the curative effect is very obvious.
Secondly, in order to facilitate the understanding of the invention, the following data of the test of the functional dendrobium wine for nourishing yin and tonifying deficiency on the mouse reproductive capacity and fatigue resistance are provided, and the technical characteristics of the invention are further explained:
test example 6 influence of functional dendrobe wine for nourishing yin and tonifying deficiency on mouse reproductive ability.
The functional dendrobe wine for nourishing yin and tonifying deficiency for the test is basically the same as the test examples 1-5, and the only difference is that: the alcohol content of the functional dendrobe wine for nourishing yin and tonifying deficiency is 48% Vol and 38% Vol.
The test is carried out by setting 4 groups of 10 mice each, the body mass is 18-22g, and the groups are respectively a negative control group, 1 group of high and low doses and a model group. Hydrocortisone is used for molding kidney-yang deficiency syndrome, except for a negative control group, the other mice are injected with 25mg/kg of hydrocortisone per day and continuously injected for 12 days, and aversion to cold and warm, cold limbs, clear and thin urine and emaciation are used as indexes for successful molding. And (3) after the model is successfully made, continuously performing intragastric administration for 30 days, and performing intragastric administration at a dose of 0.25ml/10g BW every day, wherein the high and low dose groups are respectively 48% Vol and 38% Vol functional dendrobium wine for nourishing yin and tonifying deficiency. The model group and the negative control group were each administered with the same volume of distilled water for intragastric administration.
TABLE 1 Effect of test drugs on mouse testicular weight, testosterone and luteinizing hormone production
Note: p <0.01 compared to model group.
As can be seen from Table 1, the weight of testis, testosterone and luteinizing hormone production in the model group mice were significantly decreased as compared with the negative control group, and testosterone and luteinizing hormone production were closely related to the reproductive function of mice. The functional dendrobium wine for nourishing yin and tonifying deficiency can obviously relieve the influence of hydrocortisone. Statistical analysis shows that the negative control group, the high-low dose group and the model group have significant difference (P <0.01), and the negative control group and the high-low dose group have no significant change (P > 0.05).
Test example 6 test results of test substance for mouse weight swimming test, serum urea and liver glycogen after exercise
The test is carried out by setting 4 groups of 10 mice each, the body mass is 18-22g, and the groups are respectively a negative control group, 1 group of high and low doses and a white spirit group. Continuously performing intragastric administration for 30 days, and performing intragastric administration at a dose of 0.25ml/10g BW every day, wherein the high and low dose groups are respectively 48% Vol and 38% Vol functional herba Dendrobii wine for nourishing yin and tonifying deficiency. The Chinese liquor group is filled with Chinese liquor with the same dosage. The negative control group was given an equal volume of distilled water each time.
In the heavy-load swimming experiment, 1 hour after the last administration, a 1g lead block is tied on the tail root of a mouse through a thin wire, the mouse swims in a swimming box, the water depth is 30cm, the temperature is 25 seconds and 1 degree, and the time from the beginning of swimming to the death of the mouse is the heavy-load swimming time.
Serum urea test 1 hour after the last administration, swim in water with 30 deg.C for 100min, take out the swimming box and rest for 1 hour, pick up the eyeball and take blood, and determine with enzyme method kit.
Hepatic glycogen test 1 hour after the last administration, mice were sacrificed, livers were taken, 50mg were precisely weighed, and hepatic glycogen values were measured by the anthrone method.
TABLE 2 Effect of the tested drugs on serum Urea and liver glycogen after swimming and exercise weight bearing in mice
Note: p <0.01 compared to white spirit and negative control groups.
As shown in Table 2, the weight-bearing swimming time of the mice in the functional dendrobe wine group with stomach-irrigation, yin-nourishing and deficiency-tonifying effects is significantly different from that in the negative control group and the white spirit group (P is less than 0.01). The serum urea value after exercise shows that the functional dendrobium wine group for nourishing yin and tonifying deficiency is obviously reduced compared with the negative control group and the white spirit group (P is less than 0.01). But there was no significant change in liver glycogen stores in each group (P > 0.05). The functional dendrobe wine for nourishing yin and tonifying deficiency has the effects of strengthening physique and resisting fatigue.
Thirdly, in order to further understand the invention, another preferable method for preparing the functional dendrobium wine for nourishing yin and tonifying deficiency is provided below to further illustrate the technical characteristics of the invention for the mouse reproductive capacity:
example 1
A functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following traditional Chinese medicinal materials: 30g of dendrobium huoshanense, 30g of cistanche, 45g of American ginseng, 20g of epimedium herb, 45g of medlar, 40g of prepared rehmannia root, 20g of cornus officinalis, 10g of eucommia ulmoides, 10g of loranthus parasiticus, 10g of rhizoma alismatis, 10g of bighead atractylodes rhizome fried by red soil, 5g of semen allii tuberosi, 8g of hippocampus, 5g of cornu cervi pantotrichum, 5g of liquorice and 1g of camellia extract.
The camellia oleifera flower extract is prepared by extracting camellia oleifera flower extract with petroleum ether, extracting camellia oleifera flower extract with ethyl acetate and extracting camellia oleifera flower extract with n-butanol according to a mass ratio of 1: 1: 1 are mixed.
The preparation method of the camellia oleifera flower extract comprises the following steps:
s1, drying the camellia oleifera flowers in a 50 ℃ oven, crushing and sieving with a 80-mesh sieve for later use;
s2 weighing 5kg of dried and crushed oil-tea camellia flower, adding 15L of 95% ethanol, heating, refluxing, extracting for 3 times, filtering, combining filtrates, performing rotary evaporation and concentration at 60 ℃, and evaporating in water bath to dryness to obtain an oil-tea camellia flower alcohol extract;
s3 adding 200g of camellia oleifera flower alcohol extract into 400mL of water to disperse to prepare suspension, adding petroleum ether to extract for 3 times, wherein the volume ratio of each time is 1: 1 adding a solvent, combining the upper organic solvent extraction liquid each time, collecting the lower aqueous phase, performing rotary evaporation concentration at 50 ℃, and evaporating in a water bath to dryness to obtain a camellia oleifera extract extracted by petroleum ether;
s4 adding ethyl acetate into the lower aqueous phase collected after petroleum ether extraction, and extracting for 3 times, wherein the volume ratio of each time is 1: 1 adding a solvent, combining the upper organic solvent extraction liquid each time, collecting the lower aqueous phase, performing rotary evaporation concentration at 50 ℃, and evaporating in a water bath to dryness to obtain an ethyl acetate extracted camellia oleifera extract;
s5 adding n-butanol into the lower aqueous phase collected after ethyl acetate extraction, and extracting for 3 times, wherein the volume ratio of each time is 1: 1 adding solvent, mixing the upper organic solvent extractive solutions, collecting the lower water phase, rotary evaporating at 50 deg.C for concentration, and evaporating in water bath to obtain ethyl acetate extract of Camellia oleifera flower.
The preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following steps:
s1, crushing the dendrobium huoshanense into powder of 80 meshes for later use;
s2 cleaning herba cistanches, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, fructus Corni, cortex Eucommiae, herba Taxilli, rhizoma Alismatis, rhizoma Atractylodis Macrocephalae, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and radix Glycyrrhizae;
s3, dissolving 20g of fine iodine powder into 60mL of water at 100 ℃ for later use;
s4, burning the iron pan to red, then putting the cleaned traditional Chinese medicinal materials obtained in the step S2 and the refined powder iodine salt aqueous solution obtained in the step S3 into the pan in sequence, and immediately stir-frying until the materials turn brown;
s5, simultaneously placing the dendrobium huoshanense powder obtained in the step S1, the scorched traditional Chinese medicine beverage obtained in the step S4 and the camellia oleifera flower extract into a wine jar, adding white wine for soaking for the first time, stirring for 1 time every 24 hours, and filtering out wine liquid after soaking for 15 days. Adding Chinese liquor for soaking for the second time, stirring for 1 time every 24 hr, continuously soaking for more than 12 days, filtering to obtain liquor, and mixing the liquor obtained in the two times;
s6, adding 50g of honey into 100mL of water at 50 ℃, decocting the honey into thick soup in an iron pan with slow fire, and adding the thick soup into the wine liquid to be uniformly stirred;
s7 blending the wine with sterile distilled water to obtain functional herba Dendrobii wine with effects of nourishing yin and tonifying deficiency.
The alcoholic strength of the white spirit for soaking is 60 percent Vol.
The first adding amount of the white spirit for soaking is 8 times of the total weight of the traditional Chinese medicinal materials, and the second adding amount of the white spirit for soaking is 5 times of the total weight of the traditional Chinese medicinal materials.
The alcohol content of the functional dendrobe wine for nourishing yin and tonifying deficiency is 38% Vol and 48% Vol.
Example 2
Essentially the same as example 1, with the only difference that:
the camellia oleifera flower extract is prepared by extracting camellia oleifera flower extract with petroleum ether and extracting camellia oleifera flower extract with ethyl acetate according to a mass ratio of 1: 1 are mixed.
Example 3
Essentially the same as example 1, with the only difference that:
the camellia oleifera flower extract is prepared by extracting camellia oleifera flower extract with petroleum ether and extracting camellia oleifera flower extract with n-butanol according to a mass ratio of 1: 1 are mixed.
Example 4
Essentially the same as example 1, with the only difference that:
the camellia oleifera flower extract is prepared by extracting camellia oleifera flower extract with n-butanol and extracting camellia oleifera flower extract with ethyl acetate according to a mass ratio of 1: 1 are mixed.
Comparative example 1
A functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following traditional Chinese medicinal materials: 30g of dendrobium huoshanense, 30g of cistanche, 45g of American ginseng, 20g of epimedium herb, 45g of medlar, 40g of prepared rehmannia root, 20g of cornus officinalis, 10g of eucommia bark, 10g of loranthus parasiticus, 10g of rhizoma alismatis, 10g of bighead atractylodes rhizome fried with red clay, 5g of semen allii tuberosi, 8g of hippocampus, 5g of cornua cervi pantotrichum and 5g of liquorice.
A preparation method of a functional dendrobe wine for improving yin nourishing and deficiency tonifying comprises the following steps:
s1, crushing the dendrobium huoshanense into powder of 80 meshes for later use;
s2 cleaning herba cistanches, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, fructus Corni, cortex Eucommiae, herba Taxilli, rhizoma Alismatis, rhizoma Atractylodis Macrocephalae, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and radix Glycyrrhizae;
s3, dissolving 20g of fine iodine powder into 60mL of water at 100 ℃ for later use;
s4, burning the iron pan to red, then putting the cleaned traditional Chinese medicinal materials obtained in the step S2 and the refined powder iodine salt aqueous solution obtained in the step S3 into the pan in sequence, and immediately stir-frying until the materials turn brown;
s5, simultaneously putting the dendrobium huoshanense powder obtained in the step S1 and the scorched traditional Chinese medicine beverage obtained in the step S4 into a wine jar, adding the white wine for the first time for soaking, stirring for 1 time every 24 hours, and filtering out wine liquid after soaking for 15 days. Adding Chinese liquor for soaking for the second time, stirring for 1 time every 24 hr, continuously soaking for more than 12 days, filtering to obtain liquor, and mixing the liquor obtained in the two times;
s6, adding 50g of honey into 100mL of water at 50 ℃, decocting the honey into thick soup in an iron pan with slow fire, and adding the thick soup into the wine liquid to be uniformly stirred;
s7 blending the wine with sterile distilled water to obtain functional herba Dendrobii wine with effects of nourishing yin and tonifying deficiency.
The alcoholic strength of the white spirit for soaking is 60 percent Vol.
The first adding amount of the white spirit for soaking is 8 times of the total weight of the traditional Chinese medicinal materials, and the second adding amount of the white spirit for soaking is 5 times of the total weight of the traditional Chinese medicinal materials.
The alcohol content of the functional dendrobe wine for nourishing yin and tonifying deficiency is 38% Vol and 48% Vol.
Test example 7:
examples 1-4 and comparative example 1 influence of the functional dendrobe wine for nourishing yin and tonifying deficiency on the reproductive capacity of mice.
12 groups of 10 animals are set in the test, the mass of the animals is 18-22g, and the animals are respectively a negative control group, 1 group of high and low doses of examples 1-4 and comparative example 1 and a model group. Hydrocortisone is used for molding kidney-yang deficiency syndrome, except for a negative control group, the other mice are injected with hydrocortisone 25mg/kg per day for 12 days continuously, and cold intolerance and warm pleasure, cold limbs, clear and thin urine and emaciation are used as indexes for successful molding. And (3) after the model is successfully made, continuously performing intragastric administration for 30 days, and performing intragastric administration at a dose of 0.25ml/10g BW every day, wherein the high and low dose groups are respectively 48% Vol and 38% Vol functional dendrobium wine for nourishing yin and tonifying deficiency. The model group and the negative control group were each administered with the same volume of distilled water for intragastric administration.
Table 3 examples 1-4 and comparative example 1 the effect of the tested drugs on mouse testicular weight, testosterone and luteinizing hormone production.
Note: p <0.01 compared to model group.
As can be seen from Table 3, the weight of testis, testosterone and luteinizing hormone production in the model group mice were significantly reduced compared to the negative control group compared to examples 1-4 and comparative example 1, and testosterone and luteinizing hormone production were closely related to the reproductive function of the mice. The camellia oleifera flower extract is added in the process of preparing the functional dendrobium wine for nourishing yin and tonifying deficiency, so that the influence of hydrocortisone can be remarkably relieved. The reason why the mouse testicle weight, testosterone and luteinizing hormone production of example 1 are significantly increased is that in example 1, camellia oleifera flower extract extracted by petroleum ether, camellia oleifera flower extract extracted by ethyl acetate and camellia oleifera flower extract extracted by n-butanol are added, and the three extracts are rich in various effective components of the camellia oleifera flower extract, have synergistic effect and can fully exert the effects of the three extracts.
Statistical analysis shows that the negative control group, the high-low dose group and the model group have significant difference (P <0.01), and the negative control group and the high-low dose group have no significant change (P > 0.05).
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (7)
1. A functional dendrobe wine for improving yin nourishing and deficiency tonifying is characterized by comprising the following traditional Chinese medicinal materials: herba Dendrobii, Cistanchis herba, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, Corni fructus, Eucommiae cortex, herba Taxilli, Alismatis rhizoma, Atractylodis rhizoma, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and Glycyrrhrizae radix.
2. The functional dendrobe wine for improving yin nourishing and deficiency tonifying according to claim 1, which is characterized by comprising the following Chinese medicinal materials: 20-40g of dendrobium huoshanense, 20-40g of cistanche, 35-55g of American ginseng, 10-30g of epimedium herb, 35-55g of medlar, 30-50g of prepared rehmannia root, 10-30g of cornus officinalis, 5-15g of eucommia bark, 5-15g of parasitic loranthus, 5-15g of rhizoma alismatis, 5-15g of red soil fried bighead atractylodes rhizome, 3-8g of semen allii tuberosi, 6-10g of hippocampus, 2-8g of pilose antler and 2-8g of liquorice.
3. The functional dendrobe wine for improving yin nourishing and deficiency tonifying according to claim 2, which is characterized by comprising the following Chinese medicinal materials: 30g of dendrobium huoshanense, 30g of cistanche, 45g of American ginseng, 20g of epimedium herb, 45g of medlar, 40g of prepared rehmannia root, 20g of cornus officinalis, 10g of eucommia bark, 10g of loranthus parasiticus, 10g of rhizoma alismatis, 10g of bighead atractylodes rhizome fried by red soil, 5g of semen allii tuberosi, 8g of hippocampus, 5g of cornua cervi pantotrichum and 5g of liquorice.
4. The preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying according to any one of claims 1 to 3, which is characterized by comprising the following steps:
s1, crushing the dendrobium huoshanense into powder of 60-100 meshes for later use;
s2 cleaning herba cistanches, radix Panacis Quinquefolii, herba Epimedii, fructus Lycii, radix rehmanniae Preparata, fructus Corni, cortex Eucommiae, herba Taxilli, rhizoma Alismatis, rhizoma Atractylodis Macrocephalae, semen Allii Tuberosi, Hippocampus, cornu Cervi Pantotrichum, and radix Glycyrrhizae;
s3, dissolving 10-30g of fine powder iodine salt in 50-70mL of water at 90-100 ℃ for later use;
s4, burning the iron pan to red, then putting the cleaned traditional Chinese medicinal materials obtained in the step S2 and the refined powder iodine salt aqueous solution obtained in the step S3 into the pan in sequence, and immediately stir-frying until the materials turn brown;
s5, simultaneously putting the dendrobium huoshanense powder obtained in the step S1 and the scorched traditional Chinese medicine beverage obtained in the step S4 into a wine jar, adding the white wine for soaking for the first time, stirring for 1 time every 18-24 hours, soaking for 10-15 days, and filtering out the wine. Adding Chinese liquor for the second time, soaking for more than 10-12 days, stirring for 1 time every 18-24 hr, filtering to obtain liquor, and mixing the liquor;
s6, adding 40-60g of honey into 80-120mL of 40-60 ℃ water, decocting the mixture in an iron pan with slow fire into thick soup, and adding the thick soup into wine liquid to be uniformly stirred;
s7 blending the wine with sterile distilled water to obtain functional herba Dendrobii wine with effects of nourishing yin and tonifying deficiency.
5. The preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying according to claim 4, wherein the alcoholic strength of the white spirit for soaking is 60% -65% Vol.
6. The preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying according to claim 4, wherein the first adding amount of the white spirit for soaking is 6-10 times of the total weight of the traditional Chinese medicinal materials, and the second adding amount of the white spirit for soaking is 3-7 times of the total weight of the traditional Chinese medicinal materials.
7. The preparation method of the functional dendrobe wine for improving yin nourishing and deficiency tonifying according to claim 4, which is characterized by comprising the following steps: the alcohol content of the functional dendrobe wine prepared by blending the dendrobe wine for nourishing yin and tonifying deficiency is 38-48% Vol.
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| CN112195077A (en) * | 2020-09-26 | 2021-01-08 | 齐鲁工业大学 | Formula for preparing health-preserving fermented wine from dendrobium huoshanense |
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