CN106511762B - Maca health-care wine capable of tonifying kidney and strengthening yang and preparation method thereof - Google Patents
Maca health-care wine capable of tonifying kidney and strengthening yang and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a maca health wine for tonifying kidney and strengthening yang and a preparation method thereof. On the basis of tonifying kidney and strengthening yang, the formula is compounded with the medicinal and edible traditional Chinese medicines for dispelling effects of alcohol and protecting liver, such as the flower of kudzuvine, the hovenia dulcis thunb and the like, so that the maca wine has the effects of tonifying kidney and strengthening yang, reduces the damage of alcohol to the liver, and has a remarkable curative effect on patients with kidney-yang deficiency, particularly patients with impotence.
Description
Technical Field
The invention relates to the field of health care wine, and particularly relates to maca health care wine capable of tonifying kidney and strengthening yang and a preparation method thereof.
Background
The kidney yang deficiency is caused by constitutional yang deficiency, or kidney deficiency of old people, or kidney injury due to long-term illness, and excessive sexual overstrain, and has clinical manifestations: soreness and weakness of the waist and knees, aversion to cold and cold limbs, especially lower limbs, dizziness, vertigo, listlessness, white complexion, dark tongue, pale and swollen tongue with white coating, deep and weak pulse or impotence, female infertility due to cold womb, or constipation, indigestion, diarrhea before dawn, edema, deep waist, depressed filling, abdominal pain, palpitation, cough and asthma. With the increasing pace of life and the increasing social pressure, the number of patients with kidney-yang deficiency, especially the male patients with kidney-yang deficiency who are clinically manifested as impotence, is increasing. According to incomplete statistics, the incidence rate of the adult male impotence reaches 20 percent, and the incidence rate of the male impotence above 40 years old exceeds 50 percent. The diseases caused by kidney-yang deficiency bring great harm to the body and mind of patients, and seriously affect the work and life of the patients. At present, a plurality of health care wine for tonifying kidney and strengthening yang are available in the market for treating kidney yang deficiency. Compared with common kidney-tonifying health-care medicinal liquor, such as antler wine, stiff wine, male silkworm moth wine, three-penis wine and the like, the medicinal liquor only can play a role in regulating metabolism, and has an unobvious effect on treating symptoms such as impotence and premature ejaculation caused by kidney-yang deficiency.
Modern medical researches show that Maca (Maca) is pungent in taste, slightly spicy and warm in nature, enters lung and kidney meridians, has the effects of tonifying kidney yang, benefiting essence and blood, resisting fatigue, improving fertility and the like as a medicine and food dual-purpose plant, is rich in various amino acids, active enzymes, mineral substances, trace elements and physiological active secondary metabolites required by a human body, can adjust the balance of yin and yang of the human body, promotes blood circulation, nourishes yin and tonifies yang, and effectively prevents and improves yang deficiency and body cold. Therefore, in view of the pharmacological effects of maca, a great deal of research on maca health-care medicinal liquor is carried out domestically to improve the efficacy of the health-care medicinal liquor in treating kidney-yang deficiency diseases, such as:
the Chinese invention patent CN102787062B discloses an okra and maca wine which is prepared from maca powder, okra, penis cervi, antler blood, medlar, longan pulp, deer sinew, crystal sugar, base wine and water according to a specified proportion, and has the functions of improving sexual function, increasing fertility, regulating endocrine, delaying menopause, enhancing immunity, relieving fatigue and the like.
The Chinese invention patent CN104263602A discloses a maca bull penis health care wine, which comprises the following components in parts by weight: 60-85 parts of maca and 15-40 parts of bullwhip. The maca and penis wine is prepared by extracting effective components from maca, making penis bovis into powder and adding the powder into wine, and has the effects of improving sexual function, tonifying yang and enriching blood, strengthening physique and the like.
The Chinese invention patent application CN201610232173.5 discloses a maca compound health wine, which is prepared by separately extracting maca, medlar, arillus longan, raspberry, cinnamon and mulberry with white spirits with different alcohol contents, combining the single extract according to a certain proportion, and performing the steps of reducing the alcohol content, standing, membrane filtration, big wine blending, fine filtration, canning and the like after combination.
The research shows that the health-care wine prepared by reasonably proportioning the maca and other components can really improve sexual functions and nourish yin and tonify yang, but the traditional maca wine is not suitable for long-term drinking, because drinking can easily cause alcohol to enter liver to generate toxic substance acetaldehyde to cause liver function damage, liver and kidney homology and essence-blood interaction, and liver blood can nourish kidney essence, so that the abundance and insufficiency of liver blood have an important role in the generation and regeneration of kidney essence, and the liver damage can certainly influence the functions of kidney. Therefore, the significance of researching and developing the maca health-care wine which has the effects of tonifying kidney and strengthening yang and does not hurt the liver is great.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a maca health wine capable of tonifying kidney and strengthening yang and a preparation method thereof. On the basis of tonifying kidney and strengthening yang, the maca health-care wine is compounded with the traditional Chinese medicines with homology of medicine and food, such as kudzuvine flower, hovenia dulcis thunb and the like for dispelling effects of alcohol and protecting liver, so that the maca wine has the effects of tonifying kidney and strengthening yang, reduces the damage of alcohol to the liver and is particularly suitable for patients with kidney yang deficiency to take.
The raw materials of the maca health-care wine for tonifying kidney and strengthening yang comprise maca, cistanche, morinda officinalis, wolfberry fruit, polygonatum rhizome, eucommia ulmoides, raspberry, cherokee rose fruit, leek seeds and liquorice.
The raw materials are as follows: the cistanche deserticola is sweet in taste, salty and warm in nature, has the effects of tonifying kidney yang, benefiting essence and blood and moistening intestinal tracts, can be used as both medicine and food, is proved by modern medicine to be rich in various amino acids, has the effects of enhancing resistance and resisting fatigue by trace elements required by a human body, can enhance sexual capability of human beings and animals, has great tonifying effect on male sexual organs such as kidney, testis, penis, cavernous body and the like, and has the best quality of the cistanche deserticola of Balan. The morinda officinalis has the effects of resisting fatigue strongly, enhancing the mobility, improving the cell hypoxia capability, prolonging the hypoxia tolerance time, resisting cold intolerance symptoms caused by kidney-yang deficiency, warming and invigorating kidney yang, tonifying the kidney, strengthening the body, overcoming sexual dysfunction, improving sexual activity, remarkably increasing the weight of thymus and spleen, enhancing immunity and the like. The medlar has the functions and the efficacies of tonifying the kidney and replenishing vital essence, nourishing the liver and improving eyesight, enriching the blood and soothing the nerves, promoting the production of body fluid and quenching thirst, and moistening the lung and relieving cough. It is mainly used for treating yin deficiency of liver and kidney, soreness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea. Rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney, and can be used for treating spleen and stomach weakness, tiredness, debilitation, xerostomia, anorexia, lung deficiency, cough, essence and blood deficiency, internal heat, diabetes, etc. The eucommia bark is sweet in taste and warm in nature, has the effects of tonifying liver and kidney, strengthening tendons and bones, regulating Chong and ren meridians, and securing menstruation and preventing miscarriage, and can be used for treating lumbocrural pain or soreness and weakness caused by kidney-yang deficiency, cell fetuses unconsolidation caused by liver-qi deficiency, scrotum damp itching and the like. Rubi fructus can be used for treating sexual impotence, spermatorrhea, infertility due to turbid urine, enuresis due to kidney deficiency, dim vision, and premature gray hair. Fructus Rosae Laevigatae is fruit of Rosa laevigata of Rosaceae, and has sour and astringent taste, mild property, and effects of arresting seminal emission, astringing intestine, reducing urination and relieving diarrhea. The semen Allii Tuberosi has effects of invigorating stomach, refreshing, arresting sweating, astringing, invigorating kidney, tonifying yang, and arresting spontaneous emission. Licorice root, radix Glycyrrhizae is sweet in taste and mild in nature, and enters heart, spleen, lung and stomach meridians. Raw materials are cool, and can purge fire, remove toxicity, relieve spasm and alleviate pain; moxibustion is warm in nature and can dissipate exterior cold, tonify middle-jiao and replenish qi. In addition, gan Cao is good at harmonizing property of herbs and removing toxicity of various herbs.
The raw materials of the maca health-care wine for tonifying kidney and strengthening yang also comprise flos puerariae lobatae and semen hoveniae. The flos puerariae lobatae is sweet in taste and cool in nature, has the functions of dispelling the effects of alcohol and relieving spleen, and is mainly used for treating alcoholic injury, fever, polydipsia, anorexia, vomiting and acid regurgitation. The hovenia dulcis thunb is sweet and sour and neutral in taste, and can clear heat, quench thirst, relieve alcoholism, relieve restlessness, stop vomiting and adverse rising energy and facilitate urination and defecation. Modern medical research shows that the pueraria lobata flower and the raisin tree seed can obviously reduce the concentration of ethanol in blood, promote the removal of the ethanol, eliminate excessive free radicals generated in vivo after drinking, and block the formation of lipid peroxide, thereby relieving the damage of the ethanol to liver tissues, and avoiding various metabolic abnormalities caused by alcoholism to induce various diseases.
The maca health-care wine has the effects of tonifying kidney and strengthening yang, nourishing yin and moisturizing lung, controlling nocturnal emission and reducing urination, protecting liver and improving eyesight, tonifying qi and strengthening exterior, resisting fatigue, clearing heat and removing toxicity, strengthening spleen and stomach, strengthening tendons and bones and the like, and is particularly suitable for being taken by patients with impotence caused by kidney-yang deficiency.
The raw materials of the maca health-care wine for tonifying kidney and strengthening yang comprise, by weight, 20-40 parts of maca, 10-25 parts of cistanche, 10-15 parts of morinda officinalis, 12-20 parts of wolfberry fruit, 10-15 parts of rhizoma polygonati, 10-20 parts of eucommia ulmoides, 10-20 parts of raspberry, 12-20 parts of cherokee rose fruit, 10-20 parts of leek seeds, 5-20 parts of pueraria flower, 5-20 parts of hovenia dulcis thumb and 8-15 parts of liquorice.
Preferably, the raw materials of the maca health-care wine for tonifying kidney and strengthening yang comprise, by weight, 30 parts of maca, 20 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of polygonatum rhizome, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 8 parts of pueraria flower, 8 parts of hovenia dulcis thumb and 10 parts of liquorice.
The preparation method of the maca health-care wine for tonifying kidney and strengthening yang comprises the following steps: A. cutting maca, cistanche, morinda officinalis, polygonatum rhizome, eucommia ulmoides and liquorice into pieces with cross-sectional areas of 0.2-0.5 cm2The fragments are dried at the temperature of 30-60 ℃ after being cleaned; cleaning fructus Lycii, Rubi fructus, fructus Rosae Laevigatae, semen Allii Tuberosi, flos Puerariae Lobatae, and semen Hoveniae, and air drying; B. putting the components obtained in the step A into a wine jar, and mixing the components according to the proportion of 1: 5-1: adding the white spirit according to the proportion of 10, sealing the wine jar, soaking for 30-60 days, and inverting the jar for 1-3 times every day in the soaking process; C. after the soaking time is over, opening the wine jar, and filtering to obtain the health wine. The invention adopts low-temperature drying to keep the effective components of the Chinese herbal medicine.
Preferably, the alcoholic strength of the white spirit is 42-70 degrees. The alcohol content is closely related to the curative effect of the medicinal liquor, and should not be too high or too low, because too high alcohol content can precipitate fat-soluble components but is not beneficial to dissolving water-soluble components; and the too low alcoholic strength is not beneficial to the dissolution of fat-soluble components, so that the curative effect of the medicinal liquor can be ensured only by selecting proper alcoholic strength for extraction.
Preferably, the alcohol content of the white spirit is 65 degrees, so that the kidney-yang tonifying formula for tonifying yin and yang, strengthening kidney, producing sperm and strengthening body resistance and cultivating vigor plays the maximum medicinal property.
Preferably, the degree of the health-care wine is 35-62 degrees. The maca health-care wine with different degrees in the range can be prepared according to different regions, personal preferences and the like.
The invention has the beneficial effects that: (1) according to the maca wine, the formula of the health wine is optimized, multiple Chinese herbal medicines are selected, the Chinese medicinal herbs with homology of medicine and food for dispelling effects of alcohol and protecting liver such as kudzuvine flower and hovenia dulcis are compounded on the basis of tonifying kidney and strengthening yang, when the maca wine is drunk, a protective film can be formed on the liver and the stomach, the effects of protecting the liver and nourishing the stomach are achieved, the malaise symptom of drinking is relieved by accelerating urination, perspiration and excretion and decomposition, and the drunk degree is relieved, so that the maca wine has the effects of tonifying kidney and strengthening yang, meanwhile, the damage of alcohol to the liver is reduced; (2) the traditional Chinese medicine composition disclosed by the invention is prepared by selecting reasonable and comprehensive Chinese herbal medicines, wherein the maca, the cistanche and the morinda officinalis can play a role in tonifying kidney yang, benefiting essence and blood and strengthening muscles and bones; the medlar, the sealwort and the eucommia bark can play the roles of nourishing liver and kidney, nourishing yin and moistening lung; the raspberry, the cherokee rose fruit and the leek seed have the effects of securing essence and reducing urination, warming and nourishing liver and kidney, and tonifying yang and securing essence; flos puerariae lobatae and semen hoveniae can protect liver, relieve alcoholism and relieve liver injury caused by drinking; (3) the maca health-care wine is prepared by mixing the Chinese herbal medicines and the white spirit, can exert the comprehensive effects of the medicinal materials to the maximum extent, has the effects of obviously tonifying kidney and yang, promoting the kidney to produce sperm automatically, enabling the essence and qi to be full, keeping primordial qi constant and smooth blood flow, and can assist yang to play, supplement essence and blood, benefit liver and kidney and strengthen tendons and bones, so that the effects of balancing yin and yang and tonifying at the same time are achieved, and the curative effect is obvious; (4) the maca health-care wine prepared by the invention is soft in body, pure in color, sweet and tasty, harmonious in fragrance, complementary in yin and yang, and has the effect of tonifying but not drying, thus being an ideal health-care product integrating nutrition and efficacy. The product has the obvious effects of enhancing human immunity, relieving physical fatigue, tonifying kidney and strengthening yang and treating impotence after being drunk for a long time.
Detailed Description
The invention relates to a preparation method of maca health-care wine for tonifying kidney and strengthening yang, which comprises the following steps:
A. cutting maca, cistanche, morinda officinalis, polygonatum rhizome, eucommia ulmoides and liquorice into pieces with cross-sectional areas of 0.2-0.5 cm2The fragments are dried at the temperature of 30-60 ℃ after being cleaned; cleaning fructus Lycii, Rubi fructus, fructus Rosae Laevigatae, semen Allii Tuberosi, flos Puerariae Lobatae, and semen Hoveniae, and air drying;
B. putting the components obtained in the step A into a wine jar, and mixing the components according to the proportion of 1: 5-1: 10, adding 42-70 degrees of white spirit, sealing the wine jar, soaking for 30-60 days, and inverting the jar for 1-3 times every day in the soaking process;
C. and after the soaking time is over, opening the wine jar, and filtering to obtain the 35-62-degree health wine.
The preparation method takes natural medicinal and edible materials as raw materials, and prepares the maca health wine by selecting proper alcohol content and proper material-liquid ratio to blend and filter with white spirit, thereby not only fully playing the efficacies of enhancing immunity, resisting fatigue, tonifying kidney and strengthening yang, securing essence and reducing urination, protecting liver and warming stomach, strengthening tendons and bones and the like of the raw materials, but also ensuring the efficacy, aroma and taste of the product and improving the stability of the product. The maca health-care wine prepared in the range is verified to belong to the optimal preparation method of the maca health-care wine, the preparation methods do not influence the efficacy and nutrition of the product with the same formula and proportion, the taste of the health-care wine is only different in alcohol degree (35-62 degrees), a drinker can select the health-care wine with the corresponding alcohol degree according to personal preference, the flavor of the health-care wine is the same, and the preparation method of the health-care wine listed in the following embodiment is not further limited by the embodiment of the invention.
Regarding product index detection, in the scope of the invention, various maca health-care wine prepared by the method is used as a sample, the sensory and physicochemical indexes of the sample are detected according to various national standards, and the detection results are shown in table 1:
table 1 the detection results of the product indexes of the maca health wine prepared by the present invention are as follows:
the technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The raw materials of the maca health-care wine for tonifying kidney and strengthening yang comprise, by weight, 40 parts of maca, 10 parts of cistanche, 10 parts of morinda officinalis, 12 parts of wolfberry fruit, 10 parts of polygonatum rhizome, 20 parts of eucommia bark, 20 parts of raspberry, 12 parts of cherokee rose fruit, 10 parts of leek seeds, 5 parts of pueraria flower, 5 parts of hovenia dulcis thumb and 8 parts of liquorice.
The preparation method of the maca health-care wine for tonifying kidney and strengthening yang comprises the following steps:
A. cutting maca, cistanche, morinda officinalis, polygonatum rhizome, eucommia ulmoides and liquorice into pieces with cross-sectional areas of 0.2-0.5 cm2Cleaning the fragments, and drying at the temperature of 45 ℃; cleaning fructus Lycii, Rubi fructus, fructus Rosae Laevigatae, semen Allii Tuberosi, flos Puerariae Lobatae, and semen Hoveniae, and air drying;
B. putting the components obtained in the step A into a wine jar, and mixing the components according to the proportion of 1: adding 65-degree Chinese liquor at a ratio of 10, sealing the jar, soaking for 60 days, and inverting the jar for 2 times a day during the soaking process;
C. after the soaking time is over, opening the wine jar, and filtering to obtain the 52-degree health wine.
Example 2
The raw materials of the maca health-care wine for tonifying kidney and strengthening yang comprise, by weight, 20 parts of maca, 25 parts of cistanche, 12 parts of morinda officinalis, 20 parts of wolfberry fruit, 15 parts of polygonatum rhizome, 10 parts of eucommia bark, 15 parts of raspberry, 20 parts of cherokee rose fruit, 20 parts of leek seeds, 20 parts of pueraria flower, 20 parts of hovenia dulcis thumb and 15 parts of liquorice. The preparation method of the maca health wine is the same as that of the maca health wine in example 1.
Example 3
The raw materials of the maca health-care wine for tonifying kidney and strengthening yang comprise, by weight, 35 parts of maca, 15 parts of cistanche, 10 parts of morinda officinalis, 18 parts of wolfberry fruit, 10 parts of polygonatum rhizome, 15 parts of eucommia ulmoides, 15 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 15 parts of pueraria flower, 15 parts of hovenia dulcis thumb and 10 parts of liquorice. The preparation method of the maca health wine is the same as that of the maca health wine in example 1.
Example 4
The maca health wine for tonifying kidney and strengthening yang comprises, by weight, 30 parts of maca, 20 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 8 parts of pueraria flower, 8 parts of hovenia dulcis thunb and 10 parts of liquorice. The preparation method of the maca health wine is the same as that of the maca health wine in example 1.
Comparative example 1
A maca health wine comprises, by weight, 46 parts of maca, 20 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds and 10 parts of liquorice. The preparation method of the maca health wine is the same as that of the example 1. The difference between the comparative example and the example 4 is only that the pueraria flower and the hovenia dulcis thunb are deleted from the ingredients, the content of the maca is improved, and the preparation method of the health wine is unchanged.
Comparative example 2
The invention relates to a maca health wine for tonifying kidney and strengthening yang, which comprises, by weight, 15 parts of maca, 35 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 8 parts of pueraria flower, 8 parts of hovenia dulcis thumb and 10 parts of liquorice. The comparative example is different from the example 4 only in that the content of maca in the ingredients is reduced, the content of cistanche is increased, and the preparation method of the health care wine is unchanged.
Comparative example 3
The maca health-care wine for tonifying kidney and strengthening yang comprises, by weight, 30 parts of maca, 20 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 16 parts of pueraria flower and 10 parts of liquorice. The difference between the comparative example and the example 4 is that the pueraria flower is used for completely replacing the hovenia dulcis thunb in the ingredients, and the preparation method of the health care wine is not changed.
Comparative example 4
The maca health wine for tonifying kidney and strengthening yang comprises, by weight, 30 parts of maca, 20 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 16 parts of hovenia dulcis thumb and 10 parts of liquorice. The maca health wine is different from the embodiment 4 only in that the pueraria flower is completely replaced by the hovenia dulcis thunb in the ingredients, and the preparation method of the health wine is not changed.
First, sensory evaluation
The same amount of maca health care wine in the above examples and comparative examples was taken for sensory evaluation. The evaluation mode adopts 10 points, 3 points of fragrance, 3 points of color and 4 points of taste, 10 experienced sensory panel judges the taste of the wine, and according to the total points, the results are shown in the following table 2:
table 2 the results of the comparisons are as follows:
as can be seen from the above table 2, the maca health wine prepared by the ingredients and the proportion thereof is more suitable, the medicine fragrance of the health wine is coordinated with the wine fragrance, the wine is soft, mellow and sweet, the aftertaste is long, and especially the fragrance and the taste of the health wine are optimal in the embodiment 4.
Second, pharmacodynamic test
1 test Material
1.1 test sample: the maca health-care wine prepared by the embodiments and the comparative examples listed in the invention is used as a test sample to perform evaluation tests on the effects of tonifying kidney and strengthening yang, promoting impotence and protecting liver.
1.2 animals: kunming mouse, weight 20 + -2 g; wistar rats.
2. Method and results
2.1 Effect on castration and Kidney deficiency in the Extra organs of rats
2.1.1 Effect on the sexual organs of castrated Male rats
(1) Taking 70 male rats with the weight of 102-126 g, removing bilateral testicles, injecting penicillin into muscles after operation, dividing three days after castration into 7 groups at random, wherein each group comprises 10 castration model groups, examples 1-4 and comparative examples 1 and 2, continuously irrigating the stomach for 20 days, and each day comprises 20ml of physiological saline water for irrigating the stomach of the castration model groups and corresponding maca health-care wine for irrigating the stomach of the examples and comparative examples; another 10 non-castrated rats were kept and observed in the same manner as normal control group. At 20d, the rat penis was placed with a stimulation electrode of a WQ-10B multi-use electronic acupoint apparatus, and a stimulation intensity of 3mA was applied to the electrode, and the penis erection latency (the interval from the start of stimulation to the erection of penis) was recorded, and the results are shown in Table 3.
TABLE 3 penile erection latency in groups of castrated male rats
| Group of | Latency period of penis erection (second) |
| Normal control group | 16.98±0.82 |
| Castration control group | 26.87±2.45 |
| Example 1 | 21.32±0.88***# |
| Example 2 | 22.15±0.83***# |
| Example 3 | 21.96±0.86***# |
| Example 4 | 21.03±0.82***# |
| Comparative example 1 | 22.52±1.02**# |
| Comparative example 2 | 25.42±1.24***# |
Note: p < 0.01 compared to normal control group and # P < 0.05 compared to castration model group.
As can be seen from the table 1, the maca health care wine prepared by the formula can improve the excitability of penis of castrated male rats to external stimulation, has the effect of shortening the erection latent period of the penis of the male rats, has significant difference (P is less than 0.05) compared with a castration model group, and has significant difference (P is less than 0.01) compared with a normal control group.
(2) Taking 70 male rats with the weight of 100-110 g, castrating into 7 groups, 10 male rats in each group, namely a castration model group, 1-4 male rats and comparative examples 1 and 2 male rats, and continuously performing intragastric administration for 20 days, wherein the daily volume is 20 ml; the castration model group comprises normal saline for gastric lavage, and the examples and comparative example groups comprise corresponding maca health care wine for gastric lavage; another 10 non-castrated rats were kept and observed in the same manner as normal control group. Animals were sacrificed after weighing on day 20, the seminal vesicle, prostate and glandulae preputiales were weighed rapidly and the amount per 100g of weight was calculated and the results are shown in table 4.
TABLE 4 influence of maca health wine on animal model with renal deficiency (X + -SD)
| Group of | Body weight (g) | Seminal night bag (mg) | Prostate (mg) | Glandula preputipes (mg) |
| Normal control group | 172.5±8.8 | 541.2±25.8 | 51.8±5.5 | 47.5±8.8 |
| Castration control group | 162.2±6.9 | 37.8±8.0 | 7.2±0.6 | 3.4±1.6 |
| Example 1 | 165.3±8.2 | 98.3±8.6* | 56.8±9.2* | 38.9±6.8* |
| Example 2 | 164.1±7.9 | 96.8±8.5* | 55.4±9.1* | 36.8±7.6* |
| Example 3 | 163.6±7.2 | 97.9±8.7* | 56.2±8.9* | 37.5±7.2* |
| Example 4 | 168.4±8.0 | 99.7±8.9* | 58.8±8.7* | 39.3±7.9* |
| Comparative example 1 | 163.5±7.8 | 82.5±7.8* | 52.4±8.3* | 31.2±6.4* |
| Comparative example 2 | 162.9±8.6 | 80.4±7.4* | 51.6±8.6* | 30.8±6.1* |
Note: p < 0.01 compared to the castration model group.
The results show that: the weight of animals (castrated rats) with kidney deficiency and the weight of each reproductive organ are obviously lower than those of normal control animals, which indicates that the molding of the animals with kidney deficiency is successful. The weight of the seminal fluid sac, the prostate and the glandula preputialis of the male rat of the maca health-care wine for gastric perfusion is obviously higher than that of a castration model group, which shows that the maca health-care wine has the effect of promoting the development of male organs after being taken for a long time.
2.1.2 Effect on the adnexal organs of castrated female rats
Taking 70 female rats with the weight of 100-110 g, cutting off bilateral ovaries under ether anesthesia, performing conventional anti-inflammatory treatment, randomly dividing the rats into 7 groups after 3 days, wherein each group comprises 10 female rats, namely a castration model group, examples 1-4 and comparative examples 1 and 2, and performing continuous intragastric administration for 20 days, wherein the daily volume is 20 ml; the castration model group comprises normal saline for gastric lavage, and the examples and comparative example groups comprise corresponding maca health care wine for gastric lavage; another 10 non-castrated rats were kept and observed in the same manner as normal control group. After day 20 the animals were sacrificed and the weight of the preputial glands and bilateral uteri was quickly weighed and calculated per 100g of body weight, the results are shown in table 5.
TABLE 5 Effect of the maca health wine of the invention on castrated female rats (X + -SD)
| Group of | Glandula preputipes (mg) | Uterus (mg) |
| Normal control group | 42.8±8.7 | 74.4±12.5 |
| Castration control group | 4.5±1.4 | 10.2±1.5 |
| Example 1 | 39.8±9.2* | 72.3±8.5* |
| Example 2 | 38.5±8.3* | 71.8±9.4* |
| Example 3 | 38.2±8.9* | 71.1±8.7* |
| Example 4 | 40.6±9.7* | 75.7±8.2* |
| Comparative example 1 | 35.4±8.8* | 69.5±7.8* |
| Comparative example 2 | 32.6±7.6* | 67.4±5.4* |
Note: p < 0.01 compared to the castration model group.
The results show that: the weight of periglandular glands and uterus of female animals of the maca health-care wine after gastric perfusion is obviously higher than that of a castration model group, so that the maca health-care wine has the effect of promoting development of female organs after long-term administration.
2.2 Effect on animals with Yang deficiency
Taking 70 mice, each half of the mice is male and female, randomly dividing the mice into 7 groups, wherein each group comprises 10 mice, namely a yang deficiency disease model group, examples 1-4 groups and comparative examples 1 and 2 groups, injecting 25mg/kg/d of hydrocortisone, continuously irrigating the stomach for 20d, and 20ml of the mice per day, and irrigating corresponding maca health care wine for the stomach of the yang deficiency disease model group, the examples and the comparative examples; another 10 animals were kept and observed in the same manner as the normal control group. Each group of mice was dosed once a day for 7 days, and the survival time (water temperature 10 ℃, water depth 50cm, width 50cm, swimming in swimming pool 120cm long) and the number of autonomic activities (within 10 min) of each group of mice were recorded after 1 hour of the last dose, and the test results are shown in Table 6.
Table 6 influence of the maca health wine of the present invention on yang deficiency syndrome animal low temperature swimming (X ± SD)
| Group of | Survival time for low temperature swimming (min) | Number of autonomous actions (min) |
| Normal control group | 9.7±1.1 | 19.3±1.4 |
| Castration control group | 7.1±0.8 | 8.0±0.4 |
| Example 1 | 17.2±1.6*# | 25.8±1.8*# |
| Example 2 | 16.8±1.4*# | 25.3±1.5*# |
| Example 3 | 17.1±1.2*# | 25.6±1.6*# |
| Example 4 | 18.6±1.8*# | 26.2±1.9*# |
| Comparative example 1 | 15.3±1.5*# | 22.5±1.2*# |
| Comparative example 2 | 14.2±1.1*# | 21.4±1.9*# |
Note: compared with normal control group, p is less than 0.01, compared with yang deficiency group, # p is less than 0.05.
The results show that: the large dose of hydrocortisone can cause the cold resistance and fatigue resistance of mice to be reduced, and the maca health care wine prolongs the low-temperature swimming survival time of the mice with yang deficiency, and has significant difference compared with a yang deficiency group and a normal control group. The maca health-care wine can obviously enhance the autonomous activity of mice, and has significant difference compared with a yang deficiency group and a normal control group.
2.3 liver protection efficacy verification
The reduction of liver damage according to the present invention is achieved by improving liver protection activity provided by the synergistic combination of pueraria lobata flower and hovenia dulcis thunb included in the health wine. Therefore, comparative examples 1, 3 and 4 are selected as control groups of the embodiment of the invention to study the liver protection effect of the maca health-care wine.
40 rats are taken, half of the rats are male and female, the rats are randomly divided into 4 groups, 10 rats are taken in each group, the rats are respectively the example 4 and the comparative examples 1, 3 and 4, the medicine is continuously drenched for 30 days, 20ml of the medicine is taken every day, and the maca health care wine is corresponding to the drenching of the rats in the examples and the comparative examples. On day 30, taking 0.5ml of blood from the tail of each rat every 30min after drug filling, and determining the concentration of ethanol in the blood, wherein the determination result shows that the concentration of ethanol in the blood is highest 60min after drug filling; the Malondialdehyde (MDA), Alcohol Dehydrogenase (ADH) and superoxide dismutase (SOD) activities in the blood were measured 30 days after the end of the test. The test results are shown in Table 7.
TABLE 7 Effect of maca health wine of the invention on rat liver function (X + -SD)
Note: p < 0.01 compared to comparative example 1.
Test results show that the anti-alcoholic substances contained in the flower of kudzuvine and the raisin tree seed in the maca health-care wine can improve the activity of ADH active Alcohol Dehydrogenase (ADH) and the activity of superoxide dismutase (SOD) in blood of a white rat after drinking for a long time, accelerate the catabolism speed of ethanol, reduce the content of ethanol in blood and the accumulation time of acetaldehyde as an intermediate metabolite in vivo, thereby reducing the accumulation of Malondialdehyde (MDA) and playing a role in reducing alcoholism and protecting liver function. The liver tissue HE staining result shows that the anti-alcoholism substances contained in the flower of kudzuvine and the hovenia dulcis thunb in the maca health-care wine can reduce the liver function damage caused by hepatic cell steatosis, hepatic cell necrosis, fatty liver and the like after the rats drink the wine for a long time, and the liver-protecting effect is achieved.
The pharmacodynamic test result shows that: the maca health-care wine has the effects of improving the excitability of penis of a castrated rat to external stimulation and shortening the latent period of penile erection. The maca health wine has the effects of increasing the weight of seminal fluid sacs, prostates, preputial glands and uteri for animals with kidney deficiency (castrated rats), and is identical to the effects of tonifying kidney and strengthening yang and promoting yang to wither. Can be used for improving cold tolerance, prolonging low temperature swimming time, and enhancing activity of animals (hydrocortisone mice) with yang deficiency. The sobering-up substances contained in the flower of kudzuvine and the raisin tree seed in the maca health-care wine can accelerate the catabolic speed of ethanol, reduce the ethanol content in blood and the accumulation time of an intermediate metabolite acetaldehyde in vivo, reduce the liver function damage phenomenon caused by hepatic cell steatosis, hepatic cell necrosis, fatty liver and the like after a rat drinks for a long time, and play a role in reducing alcoholism and protecting the liver function. Meanwhile, the effects are superior to the effects of the health care wine after the formula is changed according to the comparative example, which shows that the formula and the proportion of the medicinal wine are optimal, the medicinal wine can complement yin and yang, regulate the balance of yin and yang in vivo, strengthen and protect the kidney and the liver, and has obvious curative effects on the sub-health state caused by kidney-yang deficiency.
Third, clinical research
1. Trial drinking test
The maca health-care wine for tonifying kidney and strengthening yang disclosed by the invention has an obvious curative effect after being taken by patients with kidney-yang deficiency in clinic, and after being taken by 200 patients with kidney-yang deficiency in clinic (140 men and 60 women), the maca health-care wine is continuously taken for 2-3 days, and 100% of patients feel more peaceful intestines and stomach and have an enhanced appetite; 98% of patients feel refreshed and energetic after continuously taking the medicine for 7-15 days; after continuously taking the medicine for 3 months, 95 percent of patients have the renal function reaching the level of normal people, the symptoms such as soreness and weakness of waist and knees, intolerance of cold and cold limbs, impotence, premature ejaculation, spermatorrhea and the like disappear, the sexual function returns to normal, and the medicine is stopped without rebounding. After being taken by 20 cases of impotence patients clinically, the number of sperms of 9 cases of patients is increased by 35 to 45 percent after the patients continuously take the medicine for 3 months; after being taken by 18 patients with cold sperm clinically, 98 percent of the patients feel the cold sperm phenomenon relieved within 7 to 15 days, and 97 percent of the patients do not have the cold sperm phenomenon within 2 to 3 months. Because the ingredients of the maca health-care wine for tonifying kidney and strengthening yang comprise the pueraria flower and the raisin tree seed, when the health-care wine is drunk, a protective film can be formed in the liver and the stomach in advance, the effects of protecting the liver and nourishing the stomach are achieved, urination is accelerated, the uncomfortable symptoms of drinking can be relieved, and the maca health-care wine can wake up or recover the mental state quickly even if drunk, so that the daily dose of a patient can be higher than that of common medicinal wine in the market.
2. Typical case
(1) Liza, male, 50 years old, Xianning. The sexual intercourse is restrained because workers live separately in two places for a long time, and the sexual life is frequent because the sexual intercourse is not restrained in the early development stage of going back to the countryside, and the penis is gradually erected and is not hard, and the sexual intercourse is not easy to move for more than 2 years. The traditional Chinese medicine diagnosis is as follows: kidney yang deficiency. Various kidney-tonifying and yang-reinforcing medicines, health-care foods and the like have not been taken before to achieve the curative effect. Dizziness, fatigue, soreness of the waist and legs, insomnia, dreaminess, palpitation, shortness of breath, sallow complexion and poor appetite in case of fatigue. After the maca health-care wine is taken for 3 days, the appetite is enhanced, and the sleep quality is improved; after 1 month, the people are full of energy, the face color is red, the people are vigorous, and the sexual function is improved; after 3 months, the impotence symptom disappears, the sexual function returns to normal, the subjective resistance is obviously improved, and the fatigue is not easy to occur.
(2) Zhangqi, male, 32 years old, Wuhan. In 2 years after marriage, night sweat, soreness and weakness of waist and knees, impotence, unsatisfactory quality of sexual life, weakness and hypodynamia are caused, and semen is not collected until a fetus is not suffered later. The traditional Chinese medicine diagnosis is as follows: kidney yang deficiency. Various kidney-tonifying yang-invigorating medicines, health-care foods and the like have been taken once, and the effects are not good, the medicine is effective when being used, the penis is recovered, and the penis is not hard to erect. After the maca health-care wine is taken for 5 days, the libido is slightly enhanced, and the impotence is slightly improved; after 2 months of continuous use, all the symptoms of impotence, fatigue, weakness, soreness and weakness of waist and knees and the like disappear, the penis is erect and hard, the sexual life is recovered to be normal, the disease does not relapse after one year follow-up visit, and the children are born quickly.
(3) Neat, female, age 42. The following symptoms often appear in recent years: soreness of waist and backache, sallow complexion, anorexia, tinnitus, vertigo, dim eyesight, amnesia, insomnia, fatigue, dribbling after urination, nocturia, no interest in sexual intercourse, and advanced climacterium. The traditional Chinese medicine diagnosis is as follows: kidney yang deficiency. After drinking the tonic wine of the invention, 50ml is taken every day, after 3 months, people can feel energetic and not easy to fatigue, and the symptoms disappear.
In conclusion, the maca health-care wine has the effects of obviously warming and nourishing liver and kidney, tonifying yang and securing essence, enhancing immunity, relieving fatigue and the like, and has a remarkable curative effect on patients with kidney-yang deficiency, particularly patients with impotence. By changing any prescription or proportion of the traditional Chinese medicine composition, the pharmacological curative effect and the taste are not good.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The maca health-care wine for tonifying kidney and strengthening yang is characterized by comprising the following raw materials in parts by weight: 20-40 parts of maca, 10-25 parts of cistanche, 10-15 parts of morinda officinalis, 12-20 parts of wolfberry fruit, 10-15 parts of rhizoma polygonati, 10-20 parts of eucommia ulmoides, 10-20 parts of raspberry, 12-20 parts of cherokee rose fruit, 10-20 parts of leek seed, 5-20 parts of pueraria flower, 5-20 parts of hovenia dulcis thumb and 8-15 parts of liquorice.
2. The maca health wine for tonifying kidney and strengthening yang according to claim 1 is characterized by comprising the following raw materials in parts by weight: 30 parts of maca, 20 parts of cistanche, 15 parts of morinda officinalis, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 15 parts of eucommia ulmoides, 10 parts of raspberry, 15 parts of cherokee rose fruit, 15 parts of leek seeds, 8 parts of pueraria flower, 8 parts of hovenia dulcis thunb and 10 parts of liquorice.
3. The preparation method of the maca health-care wine for tonifying kidney and strengthening yang as claimed in claim 1 or 2, which is characterized by comprising the following steps: A. cutting maca, cistanche, morinda officinalis, polygonatum sibiricum, eucommia ulmoides and liquorice into pieces with the cross-sectional area of 0.2-0.5 cm2, cleaning and drying at the temperature of 30-60 ℃; cleaning fructus Lycii, Rubi fructus, fructus Rosae Laevigatae, semen Allii Tuberosi, flos Puerariae Lobatae, and semen Hoveniae, and air drying; B. putting the components obtained in the step A into a wine jar, and mixing the components according to the proportion of 1: 5-1: adding the white spirit according to the proportion of 10, sealing the wine jar, soaking for 30-60 days, and inverting the jar for 1-3 times every day in the soaking process; C. after the soaking time is over, opening the wine jar, and filtering to obtain the health wine.
4. The preparation method of the maca health-care wine for tonifying kidney and strengthening yang as claimed in claim 3, wherein the alcoholic strength of the white wine is 42-70 degrees.
5. The preparation method of the maca health-care wine for tonifying kidney and strengthening yang as claimed in claim 4, wherein the alcoholic strength of the white wine is 65 °.
6. The preparation method of the maca health-care wine for tonifying kidney and strengthening yang as claimed in claim 3, wherein the degree of the health-care wine is 35-62 degrees.
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