CN104887980A - Traditional Chinese medicine compound, preparation thereof and preparation method and application of preparation - Google Patents
Traditional Chinese medicine compound, preparation thereof and preparation method and application of preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound, a preparation thereof and a preparation method and application of the preparation. The raw materials of the compound include milkvetch root, herba cistanches, white ginseng tail, angelica, chonemorpha macrophylla, Chinese dodder herb, morinda officinalis, eucommia bark, fleeceflower root, liquorice, herba epimedii, red ginseng, barbary wolfberry fruit, American ginseng, mulberry, dendrobium candidum and rock candy. According to the compound, the significant curative effect is achieved for kidney deficiency treatment, aging resistance is provided, life can be prolonged, the safety is high, and toxic and side effects are omitted; the preparation method of the compound preparation is simple and is adaptive to industrial production; the taste layers of the compound preparation are enriched, the compound preparation is tasted mellow and sweet, dizzy and drunkenness are avoided, the digestive function and resistance of stomachs are improved, the stomach irritation caused by alcohol is reduced, and the compound is safe and effective and has promised application prospect.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly relate to a kind of Chinese medicine composition, its preparation, the preparation method of preparation and application.
Background technology
Suffer from a deficiency of the kidney: also known as " deficiency of the kidney ", refer to the vital essence loss of kidney, the traditional Chinese medical science thinks that kidney essense can nourish the five internal organs, and thinks that vital essence is lost marrow and can be caused pathological changes, and this pathological changes covers the problem of kidney and relevant urinary system and reproductive system.
The traditional Chinese medical science is thought, suffer from a deficiency of the kidney point deficiency of the kidney yin and insufficiency of kidney-YANG, will do different diagnosis and treatment according to different symptoms, suffers from a deficiency of the kidney mostly to be long term accumulation and to become disease, and the medicine of large benefits can't be used because of anxious for success to nourish, or with the kidney invigorating and YANG supporting medicine that composition is failed to understand, and should slowly nurse one's health.
According to " new Chinese medicine guideline of clinical investigations " that China Medical Science Press in 2002 publishes, the criterion to syndrome of deficiency of kidney-YANG and syndrome of deficiency of kidney yin:
Insufficiency of kidney-YANG symptom: soreness of waist and knee joint, aversion to cold and cold limbs, hyposexuality, lethargy, nocturia, edema of lower limbs, dynamic then tachypnea, pale tongue, tongue is white, and deep-slow pulse is unable.
Deficiency of the kidney yin symptom: soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, dizziness and tinnitus, dryness of the mouth and throat, hectic fever night sweat, or vaporization heat of bone, emaciated physique, insomnia forgetfulness, tooth pine loss of hairs, seminal emission, premature ejaculation, infrequent menstruation, amenorrhea, red tongue with a little fluid, few tongue or no fur, thready and rapid pulse.
" integration of edible and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science; The traditional Chinese medical science is always emphasized " medication is not as dietetic therapy ", and dietetic therapy becomes the optimum selection that modern pursues health diet; Allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery.The full nutritional formulas of wholefood clear stipulaties: 2.1.1 in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 specific full nutritional formulas: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition.
Summary of the invention
In view of this, the present invention is by experimental study, and provide a kind of Chinese medicine composition, its preparation, the preparation method of preparation and application, described Chinese medicine composition has significant curative effect to suffering from a deficiency of the kidney, and safety is high, has no side effect.
The invention discloses a kind of Chinese medicine composition, comprise following crude drug: the Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii, Radix Panacis Quinquefolii, Fructus Mori, Herba Dendrobii and crystal sugar.
Described raw material medicines in portions by weight number is preferably: the Radix Astragali 5 ~ 25 parts, Herba Cistanches 8 ~ 45 parts, fibrous root of Radix Ginseng 8 ~ 35 parts, Radix Angelicae Sinensis 5 ~ 45 parts, cattle rises 5 ~ 45 parts, Herba cuscutae 8 ~ 50 parts, Radix Morindae Officinalis 5 ~ 45 parts, the Cortex Eucommiae 7 ~ 30 parts, Radix Polygoni Multiflori 6 ~ 45 parts, 5 ~ 30 parts, Radix Glycyrrhizae, Herba Epimedii 10 ~ 45 parts, Radix Ginseng Rubra 10 ~ 35 parts, Fructus Lycii 5 ~ 45 parts, Radix Panacis Quinquefolii 10 ~ 35 parts, Fructus Mori 5 ~ 50 parts, Herba Dendrobii 5 ~ 70 parts and 30 ~ 150 parts, crystal sugar.
The present invention also provides a kind of Chinese medicinal composition preparation, comprises Chinese medicine composition described in any one provided by the invention, and described Chinese medicinal composition preparation is the one of granule, oral liquid, pill, injection, capsule, wine.
Preferably, described Chinese medicinal composition preparation is wine.
The present invention also provides a kind of preparation method of Chinese medicinal composition preparation, comprises the steps:
1) soak: by crude drug: the Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii and Radix Panacis Quinquefolii are put into 2000 parts ~ 10000 portions 55 degree of jowar wines and are soaked;
2) first time heating: by Fructus Mori and Herba Dendrobii making beating, obtained mixed juice, by mixed juice and step 1) in bubble have the jowar wine of crude drug mix and heat, be heated to 78 ~ 85 DEG C, insulation 25 ~ 45min after heating, be cooled to 40 ~ 50 DEG C after insulation at insulation 24 ~ 36h, then be cooled to room temperature, heating and cooling process in all otherwise stop stir; Every two days repeat a hyposynchronization 2) flow process, repeats 2-4 time, obtain mixed liquor;
3) second time heating: described mixed liquor is filtered obtained medicinal liquid, described medicinal liquid is added crystal sugar and is heated to 65 DEG C ~ 70 DEG C, insulation 25 ~ 35min, is cooled to room temperature after insulation, canned obtained described Chinese medicinal composition preparation.
Preferably, the alcoholic strength of described Chinese medicinal composition preparation is 30 ~ 35 degree.
The present invention also provides a kind of Chinese medicine composition to prevent and treat the application of suffering from a deficiency of the kidney in medicine in preparation, and shown by clinical trial, Chinese medicine composition provided by the invention has good therapeutic effect to Patients with Kidney Deficiency Type, evident in efficacy.
The defect undesirable to curative effect of suffering from a deficiency of the kidney for existing Chinese medicine, Western medicine toxic and side effects is larger, reasonably optimizing formula of the present invention, 16 kinds of purification of tcm are selected to form a kind of brand-new Chinese medicine composition, under the prerequisite ensureing safety, to suffering from a deficiency of the kidney, there is good curative effect, and by the principle of integration of edible and medicinal herbs, solve existing treatment by dietetic therapy and to suffer from a deficiency of the kidney the defect of medicine.
Usefulness of the present invention is:
1) Chinese medicinal composition preparation preparation method process of the present invention is simple, improves the extraction of effective ingredient in medicine, thus substantially reduces the preparation time of traditional medicated wine technique, be easy to suitability for industrialized production;
2) Traditional Chinese medicine composition formula of the present invention is reasonable, safe without toxic side effect, and therapeutic effect of suffering from a deficiency of the kidney is remarkable;
3) Chinese medicinal composition preparation mouthfeel levels are rich of the present invention, mellow sweetness, not top after drinking, not easily makes drunk, and enhances digestive function and the body resistivity of stomach, reduces ethanol to the stimulation of stomach, is a kind of effective way to keep in good health.
Detailed description of the invention
Now further describe the present invention by following examples, embodiment only for the object of illustration, does not limit the scope of the invention, and the simultaneously apparent change made according to the present invention of those of ordinary skill in the art and modification are also contained within the scope of the invention.
The preparation (1) of embodiment 1 Chinese medicine composition
By following portions by weight take each raw material (unit: g):
The preparation (2) of embodiment 2 Chinese medicine composition
By following portions by weight take each raw material (unit: g):
The preparation (3) of embodiment 3 Chinese medicine composition
By following portions by weight take each raw material (unit: g):
The preparation (4) of embodiment 4 Chinese medicinal composition preparation
By following portions by weight take each raw material (unit: g):
1) soak: by crude drug: the Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii and Radix Panacis Quinquefolii are put into 4 jin of 55 degree of jowar wines and are soaked;
2) first time heating: by Fructus Mori and Herba Dendrobii making beating, obtained mixed juice, by mixed juice and step 1) in bubble have the jowar wine of crude drug mix and heat, be heated to 78 DEG C, be incubated 25min after heating, be cooled to 40 DEG C after insulation, and be incubated 24h, be cooled to room temperature again, heating and cooling process in all otherwise stop stir; Every two days repeat a step 2) flow process, repeats 2 times, obtain mixed liquor;
3) second time heating: described mixed liquor is filtered obtained medicinal liquid, described medicinal liquid is added crystal sugar and is heated to 65 DEG C, insulation 25min, is cooled to room temperature after insulation, canned obtained described Chinese medicinal composition preparation.
The preparation (5) of embodiment 5 Chinese medicinal composition preparation
By following portions by weight take each raw material (unit: g):
1) soak: by crude drug: the Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii and Radix Panacis Quinquefolii are put into 10 jin of 55 degree of jowar wines and are soaked;
2) first time heating: by Fructus Mori and Herba Dendrobii making beating, obtained mixed juice, by mixed juice and step 1) in bubble have the jowar wine of crude drug mix and heat, be heated to 80 DEG C, be incubated 35min after heating, be cooled to 45 DEG C after insulation, and be incubated 30h, be cooled to room temperature again, heating and cooling process in all otherwise stop stir; Every two days repeat a step 2) flow process, repeats 3 times, obtain mixed liquor;
3) second time heating: described mixed liquor is filtered obtained medicinal liquid, described medicinal liquid is added crystal sugar and is heated to 68 DEG C, insulation 30min, is cooled to room temperature after insulation, canned obtained described Chinese medicinal composition preparation.
The preparation (6) of embodiment 6 Chinese medicinal composition preparation
By following portions by weight take each raw material (unit: g):
1) soak: by crude drug: the Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii and Radix Panacis Quinquefolii are put into 20 jin of 55 degree of jowar wines and are soaked;
2) first time heating: by Fructus Mori and Herba Dendrobii making beating, obtained mixed juice, by mixed juice and step 1) in bubble have the jowar wine of crude drug mix and heat, be heated to 85 DEG C, be incubated 45min after heating, be cooled to 50 DEG C after insulation, and be incubated 36h, be cooled to room temperature again, heating and cooling process in all otherwise stop stir; Every two days repeat a step 2) flow process, repeats 4 times, obtain mixed liquor;
3) second time heating: described mixed liquor is filtered obtained medicinal liquid, described medicinal liquid is added crystal sugar and is heated to 70 DEG C, insulation 35min, is cooled to room temperature after insulation, canned obtained described Chinese medicinal composition preparation.
Embodiment 7 prepares tablet or the capsule of Chinese medicine composition of the present invention
By above-mentioned raw materials medicine, add 6 times of water gagings, decoct 1 hour, leach medicine juice.Add 6 times of water gagings again, decoct 0.5 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 0.2 times, discard alcohol washing liquid, precipitate drying, for subsequent use, add starch and magnesium stearate adjuvant, vacuum drying, pulverize and granulate, be pressed into tablet or fill encapsulated.
The capsule made, every is 1.0g, and each serving with 4, every day 3 times, with (medicine) being taken before meal best results.
Embodiment 8 prepares tablet or the capsule of Chinese medicine composition of the present invention
By above-mentioned raw materials medicine, add 8 times of water gagings, decoct 2 hours, leach medicine juice.Add 8 times of water gagings again, decoct 1 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2.5 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 1 times, discard alcohol washing liquid, precipitate drying, for subsequent use; Add starch and magnesium stearate adjuvant, vacuum drying, pulverize and granulate, be pressed into tablet or fill encapsulated.
The capsule made, every is 1.0g, and each serving with 4, every day 3 times, with (medicine) being taken before meal best results.
Embodiment 9 prepares tablet or the capsule of Chinese medicine composition of the present invention
By above-mentioned raw materials medicine, add 10 times of water gagings, decoct 3 hours, leach medicine juice.Add 10 times of water gagings again, decoct 2 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 3 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 2 times, discard alcohol washing liquid, precipitate drying, for subsequent use, add starch and magnesium stearate adjuvant, vacuum drying, pulverize and granulate, be pressed into tablet or fill encapsulated.
The capsule made, every is 1.0g, and each serving with 4, every day 3 times, with (medicine) being taken before meal best results.
Embodiment 10 prepares the granule of Chinese medicine composition of the present invention
Get above-mentioned raw materials medicine, add 6 times of water gagings, decoct 1 hour, leach medicine juice.Add 6 times of water gagings again, decoct 0.5 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 0.2 times, discard alcohol washing liquid, precipitate drying, for subsequent use, add suitable pharmaceutical aids through vacuum drying, granulate, dry, granulate, obtains granule, subpackage.
Embodiment 11 prepares the granule of Chinese medicine composition of the present invention
Get above-mentioned raw materials medicine, add 8 times of water gagings, decoct 2 hours, leach medicine juice.Add 8 times of water gagings again, decoct 1 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2.5 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 1 times, discard alcohol washing liquid, precipitate drying, for subsequent use; Add suitable pharmaceutical aids, granulate, dry, granulate, obtains granule, subpackage.
Embodiment 12 prepares the granule of Chinese medicine composition of the present invention
Get above-mentioned raw materials medicine, add 10 times of water gagings, decoct 3 hours, leach medicine juice.Add 10 times of water gagings again, decoct 2 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 3 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 2 times, discard alcohol washing liquid, precipitate drying, for subsequent use; Add suitable pharmaceutical aids, granulate, dry, granulate, obtains granule, subpackage.
Embodiment 13 prepares the mixture of Chinese medicine composition of the present invention, oral liquid or syrup
By above-mentioned raw materials medicine, add 6 times of water gagings, decoct 1 hour, leach medicine juice.Add 6 times of water gagings again, decoct 0.5 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 0.2 times, discard alcohol washing liquid, precipitate drying, for subsequent use, add suitable pharmaceutical aids, make mixture, oral liquid or syrup.
Embodiment 14 prepares the mixture of Chinese medicine composition of the present invention, oral liquid or syrup
By above-mentioned raw materials medicine, add 8 times of water gagings, decoct 2 hours, leach medicine juice.Add 8 times of water gagings again, decoct 1 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2.5 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 1 times, discard alcohol washing liquid, precipitate drying, for subsequent use, add suitable pharmaceutical aids, make mixture, oral liquid or syrup.
Embodiment 15 prepares the mixture of Chinese medicine composition of the present invention, oral liquid or syrup
By above-mentioned raw materials medicine, add 10 times of water gagings, decoct 3 hours, leach medicine juice.Add 10 times of water gagings again, decoct 2 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 3 times amount 95% ethanol, stir precipitates overnight.Get precipitation, with 95% ethanol wash 3 times of 2 times, discard alcohol washing liquid, precipitate drying, for subsequent use, add suitable pharmaceutical aids, make mixture, oral liquid or syrup.
Contrast test is arranged
Arranging embodiment 1 ~ 15 is corresponding experimental group 1-15 and contrast groups 1
Contrast groups 1 is application reference number: the full nutritional formulas of tonifying YANG that in 201410402259.9 prepared by the formula of the 10th page the 32nd section and method
The clinical trial of Chinese medicine composition of the present invention
Clinical symptoms crowd: this group crowd is totally 510 examples, 30 years old-60 years old age, man 265 example, female 245 example, " the new Chinese medicine guideline of clinical investigations " all published according to China Medical Science Press in 2002 and clinical diagnosis are syndrome of deficiency of kidney-YANG syndrome of deficiency of kidney yin patient, by this group crowd random packet, this component is 1-17 group, and one group has 30 examples respectively.
Further, 1 ~ 3 group corresponding respectively takes experimental group 1 ~ 3 group of Chinese medicine composition prepared, and takes each 20ml, every day 1 time, one after each meal, avoids edible Radix Raphani, Caulis et Folium Brassicae junceae, Semen phaseoli radiati etc., within 3 days, be a course for the treatment of, take 3 courses for the treatment of continuously, advise life, diet, daily life regular.
Further, 4 ~ 15 groups of Chinese medicinal composition preparation taken experimental group 4 ~ 15 and prepare, take each 20ml, every day 3 times, one after each meal, avoids edible Radix Raphani, Caulis et Folium Brassicae junceae, Semen phaseoli radiati etc., within 3 days, be a course for the treatment of, take 3 courses for the treatment of continuously, advise life, diet, daily life regular.
Further, 16 groups of preparations taken contrast groups 1 and prepare, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and 65ml/ bottle, avoids edible Radix Raphani, Caulis et Folium Brassicae junceae, Semen phaseoli radiati etc., within 3 days, be a course for the treatment of, take 3 courses for the treatment of continuously, advises life, diet, daily life regular.
Further, disregard for 17 groups, advise life, diet, daily life regular.
Curative effect determinate standard:
" new Chinese medicine guideline of clinical investigations " according to China Medical Science Press's publication in 2002 formulates following standard:
1, methods of marking
Every patient in 4 groups of crowds holds a consultation for the first time and carries out evaluation marking according to table 1 standards of grading during further consultation after treating.
Publish syndrome of deficiency of kidney-YANG and syndrome of deficiency of kidney yin symptom in " new Chinese medicine guideline of clinical investigations " according to China Medical Science Press in 2002 to describe, by each symptom by gently, in, be heavily designated as three points, six points or nine points, carry out scalar quantization with this.
Table 1 syndrome of deficiency of kidney-YANG Syndrome Scale quantization table
Table 2 syndrome of deficiency of kidney yin Syndrome Scale quantization table
2, criterion of therapeutical effect:
Computing formula is: syndrome integral slip=[(first consultation of doctors syndrome total mark-further consultation syndrome total mark)/first consultation of doctors syndrome total mark] * 100%
1) clinical effective: syndrome integral slip >=95%
2) effectively clinical: syndrome integral slip >=50%
3) clinical invalid: syndrome integral slip <50%
3, Comparison of therapeutic table: table 3
| Group | Number of cases | Effective | Effectively | Invalid | Effective percentage |
| 1 | 30 | 24 | 4 | 2 | 93.33％ |
| 2 | 30 | 25 | 4 | 1 | 96.67％ |
| 3 | 30 | 23 | 4 | 3 | 90.00％ |
| 4 | 30 | 20 | 8 | 2 | 93.33％ |
| 5 | 30 | 25 | 4 | 1 | 96.67％ |
| 6 | 30 | 21 | 6 | 4 | 90.00％ |
| 7 | 30 | 22 | 5 | 3 | 90.00％ |
| 8 | 30 | 22 | 6 | 2 | 93.33％ |
| 9 | 30 | 24 | 3 | 3 | 90.00％ |
| 10 | 30 | 25 | 4 | 1 | 96.67％ |
| 11 | 30 | 24 | 4 | 2 | 93.33％ |
| 12 | 30 | 24 | 5 | 1 | 96.67％ |
| 13 | 30 | 23 | 4 | 3 | 90.00％ |
| 14 | 30 | 24 | 5 | 1 | 96.67％ |
| 15 | 30 | 22 | 5 | 3 | 90.00％ |
| 16 | 30 | 8 | 10 | 12 | 60％ |
| 17 | 30 | 0 | 0 | 0 | 0％ |
As can be seen here, for application number: the full nutritional formulas of tonifying YANG of 201410402259.9, Chinese medicine composition of the present invention and preparation have the effective percentage of more excellent treatment insufficiency of kidney-YANG deficiency of the kidney yin, wherein have the effective percentage of five experimental grouies to treatment insufficiency of kidney-YANG deficiency of the kidney yin all to reach more than 96%.
For further illustrating beneficial effect of the present invention, the invention provides following model case:
1, insufficiency of kidney-YANG patient: Wang, man, 45 years old, the course of disease 2 years.Without any inducement sense vertigo before 2 years, lethargy, complexion is dark, and the fat tongue of light red tongue is white, easy impotence and premature ejaculation.Start the wine prepared by the above-mentioned embodiment of the present invention 4, each 20ml, drinks 3 every day, one after each meal, avoids edible Radix Raphani, Caulis et Folium Brassicae junceae, Semen phaseoli radiati etc., and life, diet, daily life are regular.Take effect after 5 courses for the treatment of (three days being a course for the treatment of), after two courses for the treatment of, symptom obviously alleviates, and after 8 courses for the treatment of, kidney deficiency shape disappears completely.Following up a case by regular visits to 3 years, all are normal.
2, deficiency of the kidney yin patient: Lee so-and-so, female, 32 years old, abdominal compression can not cave in, distending pain, thoracic dorsal hectic fever, dizzy more than.Its clinical definite is deficiency of the kidney yin.Start the wine prepared by the embodiment of the present invention 5, each 20ml, drinks 3 every day, avoids edible Radix Raphani, Caulis et Folium Brassicae junceae, Semen phaseoli radiati etc., and life, diet, daily life are regular.1 course for the treatment of (three days being a course for the treatment of) symptom alleviates to some extent, is clearly better after 3 courses for the treatment of, 10 the course for the treatment of metanephros deficiency of YIN symptom disappear completely.
4, mouthfeel test and appraisal
Sensory evaluation by 70 age brackets 30-60 year valuation officer's Chinese medicinal composition preparation obtained to embodiment 4 ~ 6 evaluate, 1 people is only had to represent that taste is general, 69 people represent that mouthfeel is very good, mouthfeel levels are rich, mellow sweetness, not top after drinking, not easily make drunk, without the sensation of burning stomach, fruital is pleasant, peculiar.
5, other curative effects
In addition, suffer from a deficiency of the kidney while curative effect in detection, also observe this product and there is hair growth promoting nourish blood, the beneficial effects such as looks improving and the skin nourishing.
To sum up, Chinese medicine composition of the present invention is a kind of Chinese medicine composition of the safe and effective treatment insufficiency of kidney-YANG deficiency of the kidney yin had no side effect, Chinese medicinal composition preparation preparation method process of the present invention is simple, improve the extraction of effective ingredient in medicine, thus substantially reduce the preparation time of traditional medicated wine technique, be easy to suitability for industrialized production; Chinese medicinal composition preparation mouthfeel levels are rich of the present invention, mellow sweetness, not top after drinking, not easily makes drunk, and enhances digestive function and the resistivity of stomach, reduces ethanol to the stimulation of stomach, has a good application prospect.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within the scope of protection of the invention.
Claims (7)
1. a Chinese medicine composition, is characterized in that, comprises following crude drug:
The Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii, Radix Panacis Quinquefolii, Fructus Mori, Herba Dendrobii and crystal sugar.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, comprise the crude drug of following parts by weight:
The Radix Astragali 5 ~ 25 parts, Herba Cistanches 8 ~ 45 parts, fibrous root of Radix Ginseng 8 ~ 35 parts, Radix Angelicae Sinensis 5 ~ 45 parts, cattle rises 5 ~ 45 parts, Herba cuscutae 8 ~ 50 parts, Radix Morindae Officinalis 5 ~ 45 parts, the Cortex Eucommiae 7 ~ 30 parts, Radix Polygoni Multiflori 6 ~ 45 parts, 5 ~ 30 parts, Radix Glycyrrhizae, Herba Epimedii 10 ~ 45 parts, Radix Ginseng Rubra 10 ~ 35 parts, Fructus Lycii 5 ~ 45 parts, Radix Panacis Quinquefolii 10 ~ 35 parts, Fructus Mori 5 ~ 50 parts, Herba Dendrobii 5 ~ 70 parts, 30 ~ 150 parts, crystal sugar.
3. a Chinese medicinal composition preparation, is characterized in that, comprises Chinese medicine composition described in claim 1 ~ 2, and described Chinese medicinal composition preparation is the one of granule, oral liquid, pill, capsule, wine.
4. Chinese medicinal composition preparation as claimed in claim 3, it is characterized in that, described Chinese medicinal composition preparation is wine.
5. the preparation method of Chinese medicinal composition preparation as claimed in claim 4, is characterized in that, comprise the steps:
1) soak: by crude drug: the Radix Astragali, Herba Cistanches, fibrous root of Radix Ginseng, Radix Angelicae Sinensis, Niu Teng, Herba cuscutae, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Polygoni Multiflori, Radix Glycyrrhizae, Herba Epimedii, Radix Ginseng Rubra, Fructus Lycii and Radix Panacis Quinquefolii are put into 2000 parts ~ 10000 portions 55 degree of jowar wines and are soaked;
2) first time heating: by Fructus Mori and Herba Dendrobii making beating, obtained mixed juice, by mixed juice and step 1) in bubble have the jowar wine of crude drug mix and heat, be heated to 78 ~ 85 DEG C, 25min ~ 45min is incubated after heating, be cooled to 40 ~ 50 DEG C after insulation at insulation 24 ~ 36h, then be cooled to room temperature, heating and cooling process in all otherwise stop stir; Every two days repeat a step 2) flow process, repeats 2-4 time, obtain mixed liquor;
3) second time heating: described mixed liquor is filtered obtained medicinal liquid, described medicinal liquid is added crystal sugar and is heated to 65 DEG C ~ 70 DEG C, insulation 25min ~ 35min, is cooled to room temperature after insulation, canned obtained described Chinese medicinal composition preparation.
6. the preparation method of Chinese medicinal composition preparation as claimed in claim 5, it is characterized in that, the alcoholic strength of described Chinese medicinal composition preparation is 30 ~ 35 degree.
7. the application of the Chinese medicine composition described in any one of claim 1 ~ 2 in preparation control sexual dysfunction medicine.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106036818A (en) * | 2016-05-10 | 2016-10-26 | 王斌 | Capsules containing eucommia ulmoides male flowers and pollen |
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| CN1111138A (en) * | 1994-05-06 | 1995-11-08 | 广东省德庆县首乌酒厂 | Morinda officinalis tonic wine and its making process |
| CN1872246A (en) * | 2006-04-28 | 2006-12-06 | 重庆希尔安药业有限公司 | Capsule of Baji, and preparation method |
| CN103478723A (en) * | 2013-10-10 | 2014-01-01 | 哈尔滨膳宝酒业有限公司 | Formula and production method of lucid ganoderma-containing soup base for tonifying kidney deficiency and strengthening body |
| CN103784675A (en) * | 2012-12-19 | 2014-05-14 | 唐继元 | Chinese herbal medicine for treating herniae due to insufficiency of kidney yang and accumulation of dampness |
| CN104055932A (en) * | 2014-07-06 | 2014-09-24 | 杨天梅 | Herba epimedii soup |
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2015
- 2015-06-30 CN CN201510373602.6A patent/CN104887980B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111138A (en) * | 1994-05-06 | 1995-11-08 | 广东省德庆县首乌酒厂 | Morinda officinalis tonic wine and its making process |
| CN1872246A (en) * | 2006-04-28 | 2006-12-06 | 重庆希尔安药业有限公司 | Capsule of Baji, and preparation method |
| CN103784675A (en) * | 2012-12-19 | 2014-05-14 | 唐继元 | Chinese herbal medicine for treating herniae due to insufficiency of kidney yang and accumulation of dampness |
| CN103478723A (en) * | 2013-10-10 | 2014-01-01 | 哈尔滨膳宝酒业有限公司 | Formula and production method of lucid ganoderma-containing soup base for tonifying kidney deficiency and strengthening body |
| CN104055932A (en) * | 2014-07-06 | 2014-09-24 | 杨天梅 | Herba epimedii soup |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036818A (en) * | 2016-05-10 | 2016-10-26 | 王斌 | Capsules containing eucommia ulmoides male flowers and pollen |
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| CN104887980B (en) | 2019-03-22 |
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