CN103169853B - Traditional Chinese medicine composition for treating kidney yin deficiency type aplastic anemia - Google Patents

Traditional Chinese medicine composition for treating kidney yin deficiency type aplastic anemia Download PDF

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CN103169853B
CN103169853B CN201310122563.3A CN201310122563A CN103169853B CN 103169853 B CN103169853 B CN 103169853B CN 201310122563 A CN201310122563 A CN 201310122563A CN 103169853 B CN103169853 B CN 103169853B
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chinese medicine
medicine composition
aplastic anemia
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CN103169853A (en
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张晔
王立珍
井芳
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Abstract

The invention discloses a traditional Chinese medicine composition for treating kidney yin deficiency type aplastic anemia. The traditional Chinese medicine composition is prepared from alpine swertia, herba leonuri flower, radix cynanchi bungei, panax zigniberensis, radix rehmanniae preparata, Chinese avens, radix glehniae, cortex lycii radicis, mulberry fruit, semen sesami nigrum, lily and liquorice. The traditional Chinese medicine composition disclosed by the invention can be clinically used for treating kidney yin deficiency type aplastic anemia.

Description

A kind of Chinese medicine composition for the treatment of deficiency of the kidney yin type aplastic anemia
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition, especially relate to a kind of Chinese medicine composition for the treatment of deficiency of the kidney yin type aplastic anemia.
Background technology
Deficiency of the kidney yin type aplastic anemia is a kind of different substantiality disease, is the marrow hematopoiesis function failure causing due to a variety of causes, shows as the anemia illness of pancytopenia.Primary disease is in the majority with person between twenty and fifty, clinical manifestation except anemia, hemorrhage, normal companion infects and heating.Have in recent years scholar to think, the pathogenesis of chronic aplastic anemia is mainly dysimmunity.Modern medicine generally adopts blood transfusion therapy and Western medicine therapeutic alliance to deficiency of the kidney yin type aplastic anemia, but untoward reaction is heavier, is difficult to prolonged application.Draw through inventor's long-term practice, Chinese medicine is controlled deficiency of the kidney yin type aplastic anemia and is had better effect, obtains good effect.
Summary of the invention
The object of the present invention is to provide the Chinese medicine composition of the treatment deficiency of the kidney yin type aplastic anemia that a kind of therapeutic effect is good, effective percentage is high, human body is had no side effect.
The object of the present invention is achieved like this, according to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, adopt Herba Swertiae heteranthae, Flos leonuri, Radix Cynanchi Auriculati, egg seven, Radix Rehmanniae Preparata, Herba Gei, Radix Glehniae, Cortex Lycii, Fructus Trichosanthis, Herba Lophatheri, Bulbus Lilii, Radix Glycyrrhizae are according to certain compatibility requirement, through being processed into.
Preparing Chinese medicine composition of the present invention is made up of following raw material medicaments: Herba Swertiae heteranthae 55-65 part, Flos leonuri 40-45 part, Radix Cynanchi Auriculati 35-45 part, chlorella 32-42 part, Radix Rehmanniae Preparata 22-32 part, Herba Gei 21-32 part, Radix Glehniae 25-35 part, Cortex Lycii 12-22 part, Fructus Mori 11-22 part, Semen Sesami Nigrum 11-22 part, Bulbus Lilii 8-10 part, Radix Glycyrrhizae 7-10 part.
Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is: 60 parts of Herba Swertiae heteranthaes, 42 parts of Flos leonuris, 38 parts of Radix Cynanchi Auriculatis, 35 parts of chlorellas, 28 parts, Radix Rehmanniae Preparata, 26 parts of Herba Geis, 30 parts of Radix Glehniaes, 18 parts of Cortex Lycii, 16 parts of Fructus Mori, 17 parts of Semen Sesami Nigrums, 9 parts of Bulbus Liliies, 8 parts, Radix Glycyrrhizae.
The pharmacological action of Chinese medicine of the present invention is as follows:
Herba Swertiae heteranthae: sweet, micro-hardship, flat.GUIXIN, Liver Channel.Suppressing the hyperactive liver sun, tranquilizing by nourishing the heart, nourishing blood for regulating menstruation, for dizziness, neurasthenia, hypertension, anemia, the diseases such as menoxenia.
Flos leonuri: sweet, bitter, cold.Nourish blood, invigorate blood circulation, diuretic.For anemia, carbuncle pyogenic infections from tumour or sore, amenorrhea due to stagnation of blood, dysmenorrhea, the diseases such as prolonged lochia.
Radix Cynanchi Auriculati: bitter, flat.Return liver,kidney,spleen stomach warp.Invigorating the liver and kidney, bone and muscle strengthening, benefiting essence-blood, strengthening the spleen to promote digestion, detoxification sore treatment.For soreness of the waist and knees, impotence and seminal emission, dizziness and tinnitus, palpitation and insomnia, inappetence, infantile malnutrition, puerperal milk rareness, sore, carbuncle and painful swelling, venom etc.
Chlorella: clearing away heat and promoting diuresis, enrich blood.Clinical in edema, have loose bowels, hepatitis, the diseases such as anemia.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.The YIN nourishing of enriching blood, beneficial essence is filled out marrow.For blood deficiency and yellow complexion, dizzy, palpitation and insomnia; Deficiency of kidney yin and the hectic fever hectic fever due to YIN-deficiency, night sweat, the seminal emission that cause; The soreness of the waist and knees of Liver and kidney blood and essence asthenia, vertigo and tinnitus, early whitening of beard and hair etc.Herba Gei: bitter, acrid, cold.Return spleen, kidney, Liver Channel.The kidney invigorating suppressing the hyperactive liver, promoting blood circulation and detumescence.Clinical in having a dizzy spell, infantile convulsion, sexual impotence, seminal emission, anemia, cough due to consumptive disease, rheumatic arthralgia, menoxenia, the disease such as skin infection swells and ache, traumatic injury.Radix Glehniae: sweet, micro-hardship, be slightly cold, attach to the lung and stomach meridians.Nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.For the lung-heat type cough of deficiency of lung-YIN, the few expectorant of dry cough, deficiency of stomach-YIN or thermal burn stomach-Yin, the thirsty and dry pharynx of deficiency of body fluid etc.
Cortex Lycii: sweet, cold.Return lung, kidney channel.Clearind deficient heat, purte the white, removing heat from blood.For hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition heating, dyspnea and cough due to lung-heat, spits blood, and hematuria, quenches one's thirst etc.
Fructus Mori: sweet, sour, cold.Return liver, kidney channel.Nourishing YIN and benefiting blood, promotes the production of body fluid, intestine moistening.For having a dizzy spell of deficiency of the liver and kindey and blood deficiency damage of essence, soreness of waist tinnitus, early whitening of beard and hair, insomnia and dreamful sleep, Tianjin wound is thirsty, quenches one's thirst, dryness of the intestine constipation etc.
Semen Sesami Nigrum: sweet, flat.Return liver,spleen,kidney warp.Liver and kidney tonifying, the benefit that nourishes blood essence, loosening bowel to relieve constipation.Dizziness and tinnitus, waist foot flaccidity due to deficiency of the liver and kindey are soft, beard and hair is early sent out, scaly dry skin, dryness of the intestine constipation, and married woman's breast is few, carbuncle skin ulcer eczema etc.
Bulbus Lilii: sweet, micro-hardship, be slightly cold, GUIXIN, lung meridian.Nourishing YIN to relieve dryness, clearing away heart-fire for tranquillization.Cure mainly the fidgets due to deficiency palpitation with fear due to unsuccessful of deficiency of YIN chronic cough or feelings will, insomnia and dreamful sleep.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.For severe palpitation, the irregularly intermittent and regularly intermittent pulse of deficiency of heart-QI, pathopyretic ulcer, laryngopharynx swelling and pain.
Aplastic anemia, according to its anemia, hemorrhage, asthenia, dizziness, the clinical manifestation such as weak, belongs to motherland's medical science " asthenia ", " deficient " and " blood disorder " category.Motherland's medical science has unique understanding to hemopoietic theory, by raw the change of blood middle Jiao and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of mainly belonging to." blood person, foodstuff essence is also, biochemical in spleen ", " middle Jiao extracting juice of being bullied, change and red be to be blood.The relation of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and hemopoietic mainly refers to the effect of kidney, kidney governing bones, raw marrow, store essential substances, " blood is essenceization ", " the damage of essence insufficiency of blood of suffering from a deficiency of the kidney ", modern medicine thinks that bone marrow is hemopoietic tissue, contacts above-mentioned theory of Chinese medical science, motherland's medical science can be summarized as the physiological understanding of hemopoietic: diet is digested and assimilated through taste, produce cereal nutrient, be transported to bone marrow, then generate blood through the hemoposieis of bone marrow.Herba Swertiae heteranthae nourishing blood for regulating menstruation, suppressing the hyperactive liver sun in the present invention, be monarch drug, and Flos leonuri nourishes blood, invigorates blood circulation, Radix Cynanchi Auriculati invigorating the liver and kidney, benefiting essence-blood, chlorella is enriched blood, the Radix Rehmanniae Preparata YIN nourishing of enriching blood, for ministerial drug, Herba Gei the kidney invigorating suppressing the hyperactive liver, Radix Glehniae YIN nourishing and the production of body fluid promoting, Cortex Lycii clearind deficient heat, removing heat from blood, Fructus Mori nourishing YIN and benefiting blood, Semen Sesami Nigrum liver and kidney tonifying, the benefit that nourishes blood essence, Bulbus Lilii nourishing YIN to relieve dryness, the invigorating middle warmer of Radix Glycyrrhizae QI invigorating, coordinating the actions of various ingredients in a prescription.All medicines share plays enriching yin and nourishing kidney altogether, life essence-filling, marrow-benefitting, and regulating QI is nourished blood, and the effect of enriching blood finds that through clinical practice deficiency of the kidney yin type aplastic anemia is had to unique curative effect.
Chinese medicine composition of the present invention was in 2005 to 2009 clinical observation deficiency of the kidney yin type aplastic anemia 66 routine patients, and clinical report is as follows:
1, physical data
Man's 26 examples, female's 40 examples, at 21~65 years old age, average 37 years old, all meet the diagnostic criteria of deficiency of the kidney yin type aplastic anemia.
2, diagnostic criteria
(1) Western medicine diagnose standard: with reference to " diagnosis of hematological diseases and criterion of therapeutical effect " 3 editions.
1) pancytopenia, reticulocyte reduces.Lymphocyte increases relatively.
2) at least 1 position hypoplasia of bone marrow or severe lower (as active proliferation, must there be the obvious minimizing of megalokaryocyte and lymphocyte relatively to increase), bone marrow granule non-hematopoietic cell increases that (person of having ready conditions does bone marrow biopsy, show that hemopoietic tissue reduces, fatty tissue increases).
3) except energy, cause the other diseases of pancytopenia, as pancytopenia, acute aplastic crisis, the myelofibrosis, acute from disorders of blood, malignant histocytosis etc. of paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, autoantibody mediation.
(2) traditional Chinese medical science disease diagnostic criteria: with reference to " new Chinese medicine guideline of clinical investigations " (trying).
Aplastic anemia patient cardiopalmus, dizziness, the whole body is weak, and complexion, lip, fingernail are pale, and night sweat is hemorrhage, low grade fever, feverish sensation in the palms and soles, thirsty think of drink, constipation with dry stool, pale tongue or red tip of the tongue, thin fur, thready and rapid pulse, belongs to deficiency of the kidney yin type aplastic anemia.
4, Therapeutic Method
4.1 prescriptions: Herba Swertiae heteranthae 60g, Flos leonuri 42g, Radix Cynanchi Auriculati 38g, chlorella 35g, Radix Rehmanniae Preparata 28g, Herba Gei 26g, Radix Glehniae 30g, Cortex Lycii 18g, Fructus Mori 16g, Semen Sesami Nigrum 17g, Bulbus Lilii 9g, Radix Glycyrrhizae 8g.
4.2 methods of preparation and use: said medicine routinely technique is made decoction, every day 2 times, 25 days were 1 course for the treatment of at 1 dose of every day.
5, therapeutic outcome:
5.1 clinical efficacy standards: with reference to " diagnosis of hematological diseases and criterion of therapeutical effect " 3 editions
Cure: anemia, bleeding disappear, and hemoglobin reaches 120g/L (man) or 100g/L (female), and numeration of leukocyte reaches 4 × 10 9/ L, platelet count reaches 80 × 10 9/ L, follows up a case by regular visits to not recurrence above in 1 year.
Effective: anemia, bleeding disappear, and hemoglobin reaches 120g/L (man) or 100g/L (female), and numeration of leukocyte reaches 3.5 × 10 9/ L left and right, platelet count also has certain degree to increase, and follows up a case by regular visits to 3 months stable disease or continues progressive.
Effective: anemia, bleeding are clearly better, in not blood transfusion situation, hemoglobin is treated in first 1 month more than modal value increases 30g/L, and maintains 3 months and do not fall.
Invalid: through fully treatment, symptom, hemogram do not reach obvious progress.
5.2 results: in 66 routine patients, cure 24 examples (36.4%), effective 26 examples (39.3%), effective 10 examples (15.2%), invalid 6 examples (9.1%), total effective rate is 90.9%.
6, model case
6.1 Mas, female, 36 years old.Patient's complexion is greyish white, and the whole body is weak, chronognosis cold extremities, and dizziness, cardiopalmus, has gingival hemorrhage, night sweat, feverish sensation in the palms and soles, constipation with dry stool, light red tongue, white and thin fur, thready and rapid pulse.Routine blood test shows: hemoglobin 52g/L, platelet 32 × 10 9/ L.Bone marrow (ilium) puncture is shown: three is that hypertrophy is bad, meet deficiency of the kidney yin type aplastic anemia bone marrow smear, take medicine of the present invention, treat 1 course for the treatment of, patient's subjective symptoms takes a turn for the better, the whole body is unable slightly take a favorable turn before, and limbs are temperature gradually, when dizzy, does, when stool, have half congealed thin, tongue arteries and veins is the same, and routine blood test shows: hemoglobin 85g/L, platelet 57 × 10 9/ L.Continue to take 3 courses for the treatment of, patient's symptom takes a turn for the better, and the whole body is still strong, and anemia before has clear improvement, without dizzy, receive can, the peace of sleeping night, stool makes moderate progress, light red tongue, white and thin fur, thready pulse.Routine blood test shows: hemoglobin 103g/L, platelet 93 × 10 9/ L.Recovery from illness, follows up a case by regular visits to 1 year, and conditions of patients is stable, not recurrence.
6.2 what certain, man, 53 years old.Patient's lusterless complexion, skin mucosa is dispersed in petechia, gingival hemorrhage, epistaxis, dizziness, tinnitus, soreness of the waist and knees is unable, time xerostomia, receive can, the peace of sleeping night still, is hard and dry, urine is normal, tongue is dim red, white and thin fur, thready pulse.Routine blood test shows: hemoglobin 55g/L, platelet 43 × 10 9/ L; Bone marrow examination is shown: grain system, red be that hypertrophy is all low, have no megalokaryocyte, meet deficiency of the kidney yin type aplastic anemia bone marrow smear.Take medicine of the present invention, treat 1 course for the treatment of, subjective symptoms takes a turn for the better, and anemia before makes moderate progress, and skin mucosa is without petechia, time the whole body weak, dizziness, receive can, the peace of sleeping night, two just tune, tongue arteries and veins is the same.Routine blood test shows: hemoglobin 78g/L, platelet 66 × 10 9/ L, extend the interval time of transfusing blood during this time.Continue to take 2 courses for the treatment of, subjective symptoms is obviously improved, and skin mucosa has no petechia, and the whole body is strong, without symptoms such as dizziness, soreness of the waist and knees, receive can, the peace of sleeping night, two just tune, light red tongue, white and thin fur, rolling pulse.Routine blood test shows: hemoglobin 115g/L, platelet 89 × 10 9/ L, recovery from illness.Follow up a case by regular visits to 1 year, conditions of patients is stable.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and following this embodiment does not only limit the present invention for the present invention is described.
Embodiment 1, a kind of Chinese medicine composition for the treatment of deficiency of the kidney yin type aplastic anemia, be by Herba Swertiae heteranthae 55g, Flos leonuri 40g, Radix Cynanchi Auriculati 35g, chlorella 32g, Radix Rehmanniae Preparata 22g, Herba Gei 21g, Radix Glehniae 25g, Cortex Lycii 12g, Fructus Mori 11g, Semen Sesami Nigrum 11g, Bulbus Lilii 8g, Radix Glycyrrhizae 7g make.
Embodiment 2, a kind of Chinese medicine composition for the treatment of deficiency of the kidney yin type aplastic anemia, be by Herba Swertiae heteranthae 60g, Flos leonuri 42g, Radix Cynanchi Auriculati 38g, chlorella 35g, Radix Rehmanniae Preparata 28g, Herba Gei 26g, Radix Glehniae 30g, Cortex Lycii 18g, Fructus Mori 16g, Semen Sesami Nigrum 17g, Bulbus Lilii 9g, Radix Glycyrrhizae 8g make.
Embodiment 3, a kind of Chinese medicine composition for the treatment of deficiency of the kidney yin type aplastic anemia, be by Herba Swertiae heteranthae 65g, Flos leonuri 45g, Radix Cynanchi Auriculati 45g, chlorella 42g, Radix Rehmanniae Preparata 32g, Herba Gei 32g, Radix Glehniae 35g, Cortex Lycii 22g, Fructus Mori 22g, Semen Sesami Nigrum 22g, Bulbus Lilii 10g, Radix Glycyrrhizae 10g make.

Claims (2)

1. treat a Chinese medicine composition for deficiency of the kidney yin type aplastic anemia, it is characterized in that it is to be made up of following raw material medicaments:
Herba Swertiae heteranthae 55-65 part, Flos leonuri 40-45 part, Radix Cynanchi Auriculati 35-45 part, chlorella 32-42 part, Radix Rehmanniae Preparata 22-32 part, Herba Gei 21-32 part, Radix Glehniae 25-35 part, Cortex Lycii 12-22 part, Fructus Mori 11-22 part, Semen Sesami Nigrum 11-22 part, Bulbus Lilii 8-10 part, Radix Glycyrrhizae 7-10 part.
2. Chinese medicine composition according to claim 1, is characterized in that it is to be made up of following raw material medicaments:
60 parts of Herba Swertiae heteranthaes, 42 parts of Flos leonuris, 38 parts of Radix Cynanchi Auriculatis, 35 parts of chlorellas, 28 parts, Radix Rehmanniae Preparata, 26 parts of Herba Geis, 30 parts of Radix Glehniaes, 18 parts of Cortex Lycii, 16 parts of Fructus Mori, 17 parts of Semen Sesami Nigrums, 9 parts of Bulbus Liliies, 8 parts, Radix Glycyrrhizae.
CN201310122563.3A 2013-03-28 2013-03-28 Traditional Chinese medicine composition for treating kidney yin deficiency type aplastic anemia Expired - Fee Related CN103169853B (en)

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CN103749837B (en) * 2014-01-08 2015-09-09 蓝秀香 A kind of alpine swertia health-care tea

Citations (1)

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CN1171601C (en) * 2001-07-16 2004-10-20 夏伍明 Medicine 'Shenfeishu' for treating nephrosis and lung disease and its preparing process

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Publication number Priority date Publication date Assignee Title
CN1171601C (en) * 2001-07-16 2004-10-20 夏伍明 Medicine 'Shenfeishu' for treating nephrosis and lung disease and its preparing process

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