CN106344680B - A kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling and preparation method thereof - Google Patents
A kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The application belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling and preparation method thereof.The Chinese medicine composition is mainly made of following bulk pharmaceutical chemicals：Geranium wilfordii, Radix Astragali, caulis piperis futokadsurae, the root of Chinese clematis, Radix Angelicae Pubescentis, Ramulus Taxilli, pawpaw, windproof, Rhizoma Et Radix Notopterygii, pig label grass and Radix Salviae Miltiorrhizae.Result of the test shows that Chinese medicine composition and preparation can reach 86% to the total effective rate of rheumatism, rheumatoid as made from the formula of the embodiment of the present application 2,5, and more than 90% is may be up to the effective percentage of apoplexy and sequelae.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and its system with wind and relieving paralysis effect of dispelling
Preparation Method.
Background technology
Cerebral apoplexy sequela, rheumatism and rheumatoid disease are common disease, multiple disease clinically.The two seems two big systems
Disease.Doctor trained in Western medicine thinks that rheumatism and rheumatism are to belong to collagenosis, also it is believed that rheumatoid arthritis
(RA) it is a kind of chronic generalized autoimmune disease that arthrosynovitis is characterized.The lasting recurrent exerbation of synovitis, causes
The destruction of intra-articular cartilage and bone, joint function disturbance.Rheumatism, rheumatoid show as that getting up early is tired, weak, weight loss, receives
A certain arthralgia, stiff or arthrocele, handicapped then occurs for slow-witted, morning stiffness, the numb in every limb shouting pain of low-heat.The traditional Chinese medical science claims
For rheumatism.Both diseases often have very high incidence and disability rate, are caused to the life and national economy of the people
Heavy burden.
In recent years, due to the accelerating rhythm of life, life stress is big to wait many factors, and the incidence of apoplexy gradually rises.
Apoplexy, doctor trained in Western medicine claim cerebral apoplexy, are a kind of relatively low diseases of cure rate, and in China, its disability rate is up to 80%.It is modern
Medicine thinks that apoplexy includes two kinds of situations：First, bleeding caused by rupture of blood vessel in brain, oozing of blood；Second is that brain caused by cerebrovascular stenosis
Blood vessel embolism.The both of these case later stage can all cause hemiplegia, language to hold high up puckery, inconvenient walking namely cerebral apoplexy sequela.
It is complicated various for the cause of disease of above-mentioned three kinds of diseases, most scholars think with role of autoimmune factors, heredity because
Element and some other factor such as cold, humidity, wound, malnutrition, do not get enough athletic exercise, direct stimulation it is related.《The Yellow Emperor's Canon of Internal Medicine》
In it is on the books：" three gas of wind, cold, wet is miscellaneous extremely, combined into numbness.Its general mood victor is migratory arthralgia：Cold air victor is arthritis：Moisture
Victor is numbness.Supreme Being says：It has five, He YeDiscrimination uncle says：This person is met with the winter, is heumatism, this person is met with the spring, is muscular rheumatism, with
Summer meets this person, is vessle-Bi symptom-complex, is rheumatism with the muscle involved so that cloudy meet this person：This person is met with the autumn, is the numbness of the skin." in fact, the above is penetrating to be explained
The Crack cause of rheumatism and rheumatism is stated.
Modern medicine to the treatment of cerebral apoplexy sequela, rheumatism and rheumatism mainly based on antibacterial anti-inflammatory, only
Supplemented by pain and increase immunity.Western medicine can alleviate illness to a certain extent, but there are various drawbacks, and antibiosis is such as used for a long time
Element and hormone medicine cause the symptoms such as caput femoris necrosis, and huge financial burden is not only brought to patient and its family members, is also given
Patient body brings huge injury.Since traditional Chinese medicine has the characteristics that curative effect is stable, has no toxic side effect, increasingly by wide
The attention of big medical personal.It is said according to a The Yellow Emperor's Canon of Internal Medicine numbness opinion piece the 43rd：" the interior house vital organs of the human body, what gas make soDiscrimination uncle says：
The five internal organs all have conjunction, and disease is long without the person of going, and interior house is in its conjunction.Therefore heumatism is endlessly, multiple sense is in heresy, and interior house is in kidney.Muscular rheumatism is endlessly, multiple
Feel in heresy, interior house is in liver.Endlessly, multiple sense is in heresy, and interior house is in the heart for vessle-Bi symptom-complex.Endlessly, multiple sense is in heresy, and interior house is in spleen for rheumatism with the muscle involved.The numbness of the skin is not
, multiple sense is in heresy, and interior house is in lung.So-called numbness person, respectively at that time, double infection is in the wet gas of chill." more than content opinion told rheumatism
Relationship between disease, rheumatoid disease and each internal organs has established theoretical foundation for treatment rheumatism with rheumatoid disease.《Synopsis Golden Chamber》
Apoplexy joint-running abnormal pulse is demonstrate,proved and controls the 5th " pulse at CUN KOU being deep and weak, deep pulse indicating the disease affecting bone, weak i.e. main reinforcement, deep pulse indicating the kidney disease, weak as liver, sweating
Enter in water, if water is sad, joint-running Huang sweating, therefore say joint-running.", " suffering from arthritis is unable to flex and stretch the extremities pain, and Aconiti Decoction boils it." it is rheumatism
Treatment with rheumatism provides the principle of reatment that temperature is alleviated pain through dispelling cold, dehumidifying.
It is disclosed more for treating rheumatism, the Chinese medicine preparation of rheumatoid in the prior art through retrieval, such as Chinese patent
200610047095.8《Treat rheumatism, rheumatoid Chinese medicine》Disclose it is a kind of by rheum officinale, it is Rhizoma Gastrodiae, RADIX ACONITI KUSNEZIFFII, scorpio, the radix paeoniae rubrathe, sweet
The Chinese medicine preparation being applied with made of grass, the root of Dahurain angelica, rhizoma atractylodis, the fleece-flower root, ten taste medicine of Eupolyphoge sinensis, the medicine is to treatment rheumatoid, rheumatism, rheumatism
The rheumatic diseases such as migraine are cured soon, while to scapulohumeral periarthritis, knee oedema, lumbago caused by deficiency of kidney, vasculitis, pathogenic wind-toxic sore, bruise damage
The diseases such as wound also have a better effect.
Chinese patent 201210525243.8《A kind of drug for treating rheumatic and rheumatoid》It discloses a kind of use monkshood, do
The 30 multi-flavor herbal medicine such as ginger, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, vomiting nut is formulated, the drug can effectively treat rheumatic and rheumatoid diseases and
Without apparent toxic side effect, also there is the effect of fine simultaneously for lumbocrural pain caused by disc herniation and fracture pain.
But above two drug only has mitigation, but to cerebral apoplexy sequela without any to rheumatism, rheumatoid class pain
Curative effect.
Chinese patent 201610323212.2《A kind of Chinese traditional medicine composition for treating headstroke and apoplexy sequelae》It discloses and controls
Treat the Chinese medicine composition of headstroke and apoplexy sequelae, the composition be by Radix Angelicae Sinensis, Rhizoma Chuanxiong, safflower, peach kernel, cow-bezoar, cornu bubali,
Moschus, pearl powder, realgar, cinnabar, the coptis, radix scutellariae, cape jasmine, Radix Curcumae, borneol, centipede, the radix paeoniae rubrathe, full worm, leech, dried orange peel, Poria cocos,
Ramulus Taxilli, Cortex Eucommiae, prepared RHIZOMA PINELLIZE without adju-vant, the root of Chinese clematis, selfheal, radix achyranthis bidentatae, Caulis Spatholobi, Radix Glycyrrhizae, Radix Astragali and Radix Codonopsis are made.Above-mentioned application
Although preparation made of the Chinese medicine composition is described in file can treat headstroke, hemiplegia, hemiplegia, facial paralysis etc.,
But clinical test shows that therapeutic effect is not good enough.
Rheumatism, rheumatoid arthritis, there is the handicapped, deficiency of vital energy, blood stasis symptoms for cerebral apoplexy sequela.From the traditional Chinese medical science
For angle, exist and communicate part.If medical personal is on the basis of looking for the cause of disease, the specific therapeutic thoughts of establishment, flexibly
With monarch, compatibility minister, helped, made rule, provide it is a kind of can a medicine more medicament controlled, can not only reduce while rheumatism (or class wind
It is wet), the pain of the patient of headstroke, shorten treatment cycle, rheumatism (or rheumatoid) patient can also be reduced and happened suddenly headstroke
Possibility.But currently on the market and it there are no such drug.
Invention content
An object of the present invention, which is to provide one kind, has wind and relieving paralysis effect of dispelling, in rheumatism, atrophic diseases and brain
Wind sequelae is respectively provided with the Chinese medicine composition and its preparation of good therapeutic effect.
It is a further object to provide a kind of methods for preparing above-mentioned Chinese medicine composition and its preparation.
In order to achieve the above-mentioned object of the invention, a technical solution of the invention provides a kind of with wind and relieving paralysis effect of dispelling
Chinese medicine composition is mainly made of following bulk pharmaceutical chemicals：Geranium wilfordii, Radix Astragali, caulis piperis futokadsurae, the root of Chinese clematis, Radix Angelicae Pubescentis, Ramulus Taxilli, pawpaw,
Windproof, Rhizoma Et Radix Notopterygii, pig label grass and Radix Salviae Miltiorrhizae.
Preferably, the Chinese medicine composition is made of each raw material of following parts by weight：10-25 parts of geranium wilfordii, caulis piperis futokadsurae 10-
25 parts, 10-25 parts of the root of Chinese clematis, 10-25 parts of Radix Astragali, 10-20 parts of Radix Angelicae Pubescentis, 10-20 parts of Ramulus Taxilli, 10-20 parts of pawpaw, windproof 10-
20 parts, 10-20 parts of Rhizoma Et Radix Notopterygii 10-20 Fen , pig label grass, 10-20 parts of Radix Salviae Miltiorrhizae.
It is further preferred that the bulk pharmaceutical chemicals that the Chinese medicine composition is made further include Radix Angelicae Sinensis, safflower and Chinese cassia tree.
It is further preferred that the bulk pharmaceutical chemicals that the Chinese medicine composition is made further include 10-15 parts of Radix Angelicae Sinensis, safflower 10-15
Part, 10-15 parts of Chinese cassia tree.
Still further it is preferably made from each bulk pharmaceutical chemicals geranium wilfordii of the Chinese medicine composition, Radix Astragali, caulis piperis futokadsurae, Wheeling
Celestial being, Radix Angelicae Pubescentis, Ramulus Taxilli, pawpaw, windproof, Rhizoma Et Radix Notopterygii, pig label grass, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, safflower and the weight ratio of Chinese cassia tree are 5:5:5:4:3:
4:3:3:4:3:3:3:2:2。
Still further it is preferably made from each bulk pharmaceutical chemicals geranium wilfordii of the Chinese medicine composition, Radix Astragali, caulis piperis futokadsurae, Wheeling
Celestial being, Radix Angelicae Pubescentis, Ramulus Taxilli, pawpaw, windproof, Rhizoma Et Radix Notopterygii, pig label grass, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, safflower and the weight ratio of Chinese cassia tree are 4:4:4:3:2:
3:2:2:3:2:2:2:1:1。
As a kind of embodiment, the Chinese medicine composition is made of each raw material of following parts by weight：25 parts of geranium wilfordii, Huang
25 parts of stilbene, 25 parts of caulis piperis futokadsurae, 20 parts of the root of Chinese clematis, 15 parts of Radix Angelicae Pubescentis, 20 parts of Ramulus Taxilli, 15 parts of pawpaw, 15 parts windproof, 20 parts of Rhizoma Et Radix Notopterygii,
15 parts of pig label grass, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Angelicae Sinensis, 10 parts of safflower, 10 parts of Chinese cassia tree.
As another embodiment, the Chinese medicine composition is made of each raw material of following parts by weight：20 parts of geranium wilfordii,
20 parts of Radix Astragali, 20 parts of caulis piperis futokadsurae, 15 parts of the root of Chinese clematis, 10 parts of Radix Angelicae Pubescentis, 15 parts of Ramulus Taxilli, 10 parts of pawpaw, 10 parts windproof, Rhizoma Et Radix Notopterygii 15
10 parts of Fen, pig label grass, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Radix Angelicae Sinensis, 5 parts of safflower, 5 parts of Chinese cassia tree.
Another technical solution of the application provides a kind of leading to wind-dispelling comprising any of the above-described Chinese medicine composition
The preparation of numbness effect is one kind in pill, particle, syrup, capsule and tablet, preferably pill.In above-mentioned preparation also
Include pharmaceutically acceptable auxiliary material
Another technical solution of the application provides the Chinese medicine composition described in a kind of prepare with wind and relieving paralysis effect of dispelling
Method, be as follows：
1) each bulk pharmaceutical chemicals are weighed by weight, after crushing, respectively by geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, caulis piperis futokadsurae, Wheeling
Celestial being, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii cross 10-50 mesh and sieve to obtain coarse powder；Pawpaw, pig label grass, Radix Angelicae Sinensis, safflower, Chinese cassia tree cross 80-100 mesh respectively
Sieve to obtain fine powder；
2) purified water is added in after the coarse powder of geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae is mixed to decoct 1-3 times, it is 1-3 hours each,
Merging filtrate after filtering is concentrated to give the medicinal extract 1 that 25 DEG C of relative densities are 1.1-1.36；
After caulis piperis futokadsurae, the root of Chinese clematis, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii coarse powder are mixed, the second for being 55-75% with volume fraction
Alcohol percolation collects 6-8 times of percolate, ethyl alcohol is recovered under reduced pressure, and is concentrated to give the medicinal extract 2 that 25 DEG C of relative densities are 1.15-1.29；
3) fine powder obtained in step 1) is mixed with medicinal extract 1,2 up to Chinese medicine composition.
Preferably, the purified water for being equivalent to 6-8 times of weight of purified water is added in step 2).
It is prepared by the conventional means that those skilled in the art can be used in the preparation that the application provides.
One of technical solution of the application provides a kind of method for preparing the pill with wind and relieving paralysis effect of dispelling,
It is as follows：
It is having bonding, rectifying for 5-8% that its weight 10-15% mass concentrations are added in into Chinese medicine composition obtained above
Pill, drying are to get target pill after the solution of taste effect.
Preferably, the solution with bonding, flavored action is one kind in sucrose, mannitol and chitosan；It is described
Dry temperature is 65-75 DEG C.
Wherein, the pharmacological action of each bulk pharmaceutical chemicals of herein described Chinese medicine composition and side's solution are as follows：
Radix Astragali：Tonifying Qi and lifting yang, temperature are cured mainly through detumescence：Deficient qi and blood, blood-arthralgia pain subcutaneous ulcer；
Caulis piperis futokadsurae：It is dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, it cures mainly：Rheumatoid, rheumatism, arthritis；
The root of Chinese clematis：Dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain, and is cured mainly：Arthralgia pain due to rheumatism, extremity numbness；
Radix Angelicae Pubescentis：Dispelling wind and eliminating dampness, numbness relieving and pain relieving, cure mainly：Rheumatism numbness pain, waist and knee；
Radix Angelicae Sinensis：It enriches blood, invigorate blood circulation, remove obstruction in channels to relieve pain, cure mainly：Cold of insufficiency type pain；
Ramulus Taxilli：Kidney tonifying strengthens muscles and bones, wind-damp dispelling, cures mainly：Arthralgia pain due to rheumatism, pain in waist and lower extremities；
Pawpaw：Relaxing muscles and tendons and network, stomach dampness elimination, cure mainly：Arthritis with fixed pain caused by dampness arrests twin, waist and knee celebrating section pain；
Geranium wilfordii：It is dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, it cures mainly：Wind-cold-dampness arthralgia, limbs pain；
Safflower：Invigorate blood circulation, stasis-dispelling and pain-killing, cure mainly：Lumbocrural pain, fracture and pain-stop；
Rhizoma Et Radix Notopterygii：Relieving exterior syndrome and dispelling cold, dispelling wind and eliminating dampness, analgesic, cure mainly：Headache, Xiang Qiang, limbs pain；
Pig label grass：Dispelling wind and eliminating dampness, analgesic, relieving rigidity of muscles and joints, cure mainly：Rheumatic arthritis；
It is windproof：Dispelling wind and eliminating dampness cures mainly：Arthralgia pain due to rheumatism；Radix Salviae Miltiorrhizae：Promoting blood circulation proceeds blood cycle, and cures mainly：Wandering arthritis pain is swollen；Meat
Osmanthus：Mends fire supporing yang, cold-dispelling pain-relieving, cure mainly：Decline of kidney-YANG, waist and knee numbness pain.
Wherein, geranium wilfordii, Radix Astragali, caulis piperis futokadsurae and the root of Chinese clematis are monarch drug in a prescription in we,
Radix Astragali nature and flavor are sweet warm-natured, specially take charge of QI invigorating reinforcing because of qi being the governor of blood, promote blood circulation, and can inducing diuresis for removing edema；Sea
Wind rattan property is pungent, bitter, tepor, has the effect of dispelling wind and eliminating dampness, cold dispelling channels sootheing and network vessel quickening；The root of Chinese clematis is pungent, sweet, warm-natured, and work(kidney-replenishing is dispelled
Rheumatism, removing dampness and warming kidney yang-tonifying also have adrenocortical hormones fuction outside；Geranium wilfordii is pungent, bitter flat, and Return liver, kidney, the spleen channel have
The effects that wind-dispelling degrading the channel.The effect of four medicines are shared with dispelling wind and eliminating dampness, cold dispelling channels sootheing and network vessel quickening.
Radix Angelicae Pubescentis, Ramulus Taxilli, pawpaw, windproof, Rhizoma Et Radix Notopterygii, pig label grass and seven taste ministerial drug of Radix Salviae Miltiorrhizae, share one action multipotency, first can temperature
Kidney yang-tonifying, warm venting QI-blood, a surname's network exempt from numbness；Second blood circulation promoting nourishes blood is elder generation's rhymed formula of wind-dispelling.Ancients' cloud：It " controls wind and first controls blood, blood wind
From going out ", Gu Zuo is with Radix Angelicae Sinensis, safflower, with Chinese cassia tree guiding fire to origin.Three green bloods of enriching blood are the key medicine of righting, amount to its medicine and get rid of evils
Without hindering purpose just.
It is strong that above-mentioned each medicine shares nature and flavor hero, can declare logical hundred arteries and veins, between the channels joint that goes directly；Reconciliation channels and collaterals lead to muscles and bones, close
Section, have the function of dispelling wind and eliminating dampness, inducing meastruation to relieve menalgia, relaxing tendons and activating collaterals, it is promoting blood circulation and removing blood stasis, strengthen muscles and bones.
Compared with prior art, the Chinese medicine composition with wind and relieving paralysis effect of dispelling or its preparation that the application provides are with such as
Lower advantageous effect：
(1) Chinese medicine composition that the application provides can be used for the disease with rheumatism, especially rheumatism, rheumatoid disease
The treatment of disease, apoplexy and apoplexy sequelae.Result of the test shows the Chinese traditional medicine composition as made from the formula of the embodiment of the present application 2,5
Object and preparation can reach 86% to the total effective rate of rheumatism, rheumatoid, the effective percentage of apoplexy and sequelae may be up to 90% with
On.
(2) Chinese medicine composition that the application provides is pure Chinese medicine formula, and animal test results show what is provided by the application
Chinese medicine composition is toxic formulation, available for anti-inflammatory, inducing meastruation to relieve menalgia, detumescence.
Specific embodiment
The present invention is further elaborated with reference to embodiment.These embodiments be only for illustrative purposes,
And do not limit the scope of the invention and essence.
Embodiment 1
A kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：Old stork
25 parts of grass, 20 parts of caulis piperis futokadsurae, 22 parts of the root of Chinese clematis, 18 parts of Radix Astragali, 13 parts of Radix Angelicae Pubescentis, 15 parts of Ramulus Taxilli, 18 parts of pawpaw, windproof 15 parts,
18 parts of 15 Fen , pig label of Rhizoma Et Radix Notopterygii grass, 20 parts of Radix Salviae Miltiorrhizae.
Wherein, the preparation method of the Chinese medicine composition is as follows：
1) each bulk pharmaceutical chemicals are weighed by weight, after crushing, respectively by geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, caulis piperis futokadsurae, Radix Salviae Miltiorrhizae, Wheeling
Celestial being, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii cross 20 mesh and sieve to obtain coarse powder；Pawpaw, pig label grass sieves with 100 mesh sieve to obtain fine powder respectively；
2) addition purified water decoction 2 times after the coarse powder of geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae is mixed, 2.5 hours every time, mistake
Merging filtrate after filter is concentrated to give the medicinal extract 1 that 25 DEG C of relative densities are 1.18；
After caulis piperis futokadsurae, the root of Chinese clematis, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii coarse powder are mixed, oozed with the ethyl alcohol that volume fraction is 70%
It filters, collects 8 times of percolates, ethyl alcohol is recovered under reduced pressure, be concentrated to give the medicinal extract 2 that 25 DEG C of relative densities are 1.29；
3) fine powder obtained in step 1) is mixed with medicinal extract 1,2 up to Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：
25 parts of geranium wilfordii, 25 parts of caulis piperis futokadsurae, 25 parts of the root of Chinese clematis, 20 parts of Radix Astragali, 18 parts of Radix Angelicae Pubescentis, 20 parts of Ramulus Taxilli, pawpaw 15
Part, windproof 18 parts, 18 parts of 18 Fen , pig label of Rhizoma Et Radix Notopterygii grass, 18 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Angelicae Sinensis, 15 parts of safflower, 12 parts of Chinese cassia tree.
Wherein, the preparation method of the Chinese medicine composition is as follows：
1) each bulk pharmaceutical chemicals are weighed by weight, after crushing, respectively by geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, caulis piperis futokadsurae, Wheeling
Celestial being, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii cross 50 mesh and sieve to obtain coarse powder；Pawpaw, pig label grass, Radix Angelicae Sinensis, safflower, Chinese cassia tree sieve with 100 mesh sieve carefully respectively
Powder；
2) purified water is added in after the coarse powder of geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae is mixed to decoct 2 times, 2 hours every time, is filtered
Merging filtrate afterwards is concentrated to give the medicinal extract 1 that 25 DEG C of relative densities are 1.26；
After caulis piperis futokadsurae, the root of Chinese clematis, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii coarse powder are mixed, oozed with the ethyl alcohol that volume fraction is 75%
It filters, collects 6 times of percolates, ethyl alcohol is recovered under reduced pressure, be concentrated to give the medicinal extract 2 that 25 DEG C of relative densities are 1.18；
3) fine powder prepared in step 1) is mixed with medicinal extract 1,2 up to Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：
25 parts of geranium wilfordii, 25 parts of Radix Astragali, 25 parts of caulis piperis futokadsurae, 20 parts of the root of Chinese clematis, 15 parts of Radix Angelicae Pubescentis, 20 parts of Ramulus Taxilli, pawpaw 15
Part, windproof 15 parts, 15 parts of 20 Fen , pig label of Rhizoma Et Radix Notopterygii grass, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Angelicae Sinensis, 10 parts of safflower, 10 parts of Chinese cassia tree.
Wherein, the preparation method of the Chinese medicine composition is substantially the same as embodiment 2.
Embodiment 4
A kind of Chinese medicine composition for wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：
10 parts of geranium wilfordii, 15 parts of Radix Astragali, 20 parts of caulis piperis futokadsurae, 10 parts of the root of Chinese clematis, 15 parts of Radix Angelicae Pubescentis, 20 parts of Ramulus Taxilli, pawpaw 12
Part, windproof 20 parts, 10 parts of 10 Fen , pig label of Rhizoma Et Radix Notopterygii grass, 20 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Angelicae Sinensis, 15 parts of safflower, 15 parts of Chinese cassia tree.
Wherein, the preparation method of the Chinese medicine composition is substantially the same as embodiment 2.
Embodiment 5
A kind of pill with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：
20 parts of geranium wilfordii, 20 parts of Radix Astragali, 20 parts of caulis piperis futokadsurae, 15 parts of the root of Chinese clematis, 10 parts of Radix Angelicae Pubescentis, 15 parts of Ramulus Taxilli, pawpaw 10
Part, windproof 10 parts, 10 parts of 15 Fen , pig label of Rhizoma Et Radix Notopterygii grass, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Radix Angelicae Sinensis, 5 parts of safflower, 5 parts of Chinese cassia tree.
The preparation method of the pill is as follows：
1) Chinese medicine composition is made according to the method described in same embodiment 2；
2) added in into Chinese medicine composition obtained above 10% mass concentration be 8% sucrose solution after pill, in 60-
65 DEG C of dry 8h are to get target pill；
The pill, drying process use the common process of those skilled in the art.
Embodiment 6
A kind of pill with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：25 parts of geranium wilfordii,
20 parts of caulis piperis futokadsurae, 22 parts of the root of Chinese clematis, 18 parts of Radix Astragali, 13 parts of Radix Angelicae Pubescentis, 15 parts of Ramulus Taxilli, 18 parts of pawpaw, windproof 15 parts, Rhizoma Et Radix Notopterygii 15
18 parts of Fen , pig label grass, 20 parts of Radix Salviae Miltiorrhizae, 10 parts of prepared rehmannia root, 5 parts of motherwort, 5 parts of Chinese yam.
The preparation method of the pill is as follows：
1) each bulk pharmaceutical chemicals are weighed by weight, after crushing, respectively by geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, caulis piperis futokadsurae, Wheeling
Celestial being, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii cross 50 mesh and sieve to obtain coarse powder；Pawpaw, pig label grass, prepared rehmannia root, motherwort, Chinese yam sieve with 100 mesh sieve respectively
Obtain fine powder；
2) purified water is added in after the coarse powder of geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae is mixed to decoct 2 times, 2 hours every time, is filtered
Merging filtrate afterwards is concentrated to give the medicinal extract 1 that 25 DEG C of relative densities are 1.26；
After caulis piperis futokadsurae, the root of Chinese clematis, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii coarse powder are mixed, oozed with the ethyl alcohol that volume fraction is 75%
It filters, collects 6 times of percolates, ethyl alcohol is recovered under reduced pressure, be concentrated to give the medicinal extract 2 that 25 DEG C of relative densities are 1.18；
3) fine powder prepared in step 1) is mixed with medicinal extract 1,2 up to Chinese medicine composition,
4) added in into Chinese medicine composition made from step 3) 10% mass concentration be 8% sucrose solution after pill, in
60-65 DEG C of dry 8h is to get target pill.
Comparative example 1
A kind of pill with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：
30 parts of Radix Astragali, 30 parts of caulis piperis futokadsurae, 15 parts of the root of Chinese clematis, 10 parts of Radix Angelicae Pubescentis, 15 parts of Ramulus Taxilli, 15 parts of pawpaw, 20 parts of Rhizoma Et Radix Notopterygii,
10 parts of pig label grass, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Radix Angelicae Sinensis, 5 parts of safflower, 5 parts of Chinese cassia tree.
The preparation method of the pill is substantially the same as embodiment 5.
Comparative example 2
A kind of pill with wind and relieving paralysis effect of dispelling, is mainly made of the bulk pharmaceutical chemicals of following parts by weight：
5 parts of geranium wilfordii, 25 parts of Radix Astragali, 20 parts of caulis piperis futokadsurae, 15 parts of the root of Chinese clematis, 10 parts of Radix Angelicae Pubescentis, 15 parts of Ramulus Taxilli, pawpaw 10
Part, windproof 10 parts, 10 parts of 15 Fen , pig label of Rhizoma Et Radix Notopterygii grass, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Radix Angelicae Sinensis, 10 parts of safflower, 10 parts of Chinese cassia tree.
The preparation method of the pill is substantially the same as embodiment 5.
Pharmacodynamics test
1st, acute toxicity test in mice
Take 18-22g kunming mices 80, half male and half female is divided into 8 groups, administration group and blank control group.
Administration group mouse distinguishes gavage Chinese medicine composition 1000mg/kg, 1200mg/kg as made from embodiment 3,
1440mg/kg, 1680mg/kg, 2200mg/kg, 2400mg/kg, 2520mg/kg, blank control group intragastric administration on mice water for injection
The toxic reaction of 7 days animals is observed continuously in (9mL/20g) after administration, appetite, behavioral activity, the state of mind including mouse, big
Urine and hair, breathing, mouth, nose, eye, ear, anus etc. whether there is situations such as abnormal secretion, changes of weight and death.
The results show that activity is slightly reduced indivedual administration group mouse upon administration, it is other to be showed no exception.But the 2nd day 70
Mouse diet, activity are normal.It is observed continuously 7 days, spirit, appetite, the colour of skin, secretion, muscular movement of whole mouse etc.
Aspect does not observe anomalous variation, different without the sight of apparent eye from blank control group.The Chinese medicine composition provided due to this experiment
Dosage increase to 2520mg/kg, 70 mouse are still strong to live, and illustrates Chinese medicine composition that the application provides to mouse safety nothing
Poison.
Moreover, using identical method, it is equal to measure Chinese medicine composition and pill made from the embodiment of the present application 1,2,4,5,6
It is safe and non-toxic to mouse.
2nd, the anti-inflammatory effect of Chinese medicine composition
1) influence increased to mouse peritoneal injection acetic acid induced mice capillary permeability
Take 18-22g kunming mices 50, half male and half female, every group 10, totally 5 groups.Positive controls, blank control group and
Test group.Wherein, positive controls gavage aspirin (10mg/20g), blank control group gavage medical saline (9mL/
20g), test group gavage Chinese medicine composition as made from embodiment 3 low (5mg/20g), in (8mg/20g), high (22mg/20g)
Dosage group.Unless otherwise specified, it is generally administered once a day, laboratory temperature is controlled at 18-28 DEG C, makes standard particle feed by oneself
It feeds, freely ingests, takes the photograph water.Administration 7 days, 1 time a day, in administration the 7th day, after last dose 40min, each equal tail vein note of mouse
1% Evans blue (0.1mL/g) is penetrated, 0.6%HAc0.1mL/10g is injected intraperitoneally immediately, mouse, abdominal cut are put to death after 20min
Integumentary musculature with 6mL normal saline flushings abdominal cavity, draws cleaning solution, centrifugation washing lotion 15min (3000rpm) takes with syringe
Clear liquid surveys its absorbance (A) at spectrophotometer 590nm.As a result it see the table below 1.
Influence of 1 Chinese medicine composition of table to mouse peritoneal capillary permeability
The result shows that the high dose group of the Chinese medicine composition as made from embodiment 3 significantly can inhibit acetic acid caused by mouse
The increase of abdominal cavity capillary permeability, but low dose group effect is weaker.
2) influence of rat angle plantar swelling caused by Chinese medicine composition Carrageenan inflammation
The male rat 50 of 200-220g is taken, is randomly divided into 5 groups, every group 10.Wherein, positive controls gavage Ah Si
Woods (10mg/20g), blank control group gavage medical saline (9mL/20g), test group gavage is as made from embodiment 4
Chinese medicine composition low (3.5mg/20g), in (6.5mg/20g), high (15mg/20g) dosage group.By above-mentioned test example 1) in method
Administration, once a day, continuous 5 days, after last dose 1h, vola pedis was subcutaneously injected into 1% carrageenan 0.1mL/ only after Rat Right,
1.0h, 2.0h, 3.0h, 4.0h, 5.0h, 6.0h after inflammation is caused to measure rat paw volume respectively, calculates swelling angle value (after causing inflammation
Foot plantar volume and the difference for causing foot plantar volume before inflammation).As a result such as following table 2.
The influence of rat paw edema caused by 2 Chinese medicine composition Carrageenan of table
The result shows that the middle and high dosage group for the Chinese medicine composition that the embodiment of the present application 4 provides can be apparent when 3h starts
Rat paw edema caused by inhibiting carrageenan.
3rd, the analgesic activity of Chinese medicine composition
Mouse analgesic test
20-25g kunming mices 50 are taken, half male and half female is randomly divided into 5 groups, every group 10.Wherein blank control group gavage
Medicinal purified water (9mL/20g), positive controls gavage aspirin (10mg/20g), test group gavage are made by embodiment 3
Chinese medicine composition low (3.5mg/20g), in (6.5mg/20g), high (15mg/20g) dosage group.By above-mentioned test example 1) in side
Method is administered, and once a day, continuous 5 days, after last dose 1h, 0.7% glacial acetic acid (0.15mL/10g) is injected intraperitoneally, observes every
Writhing number caused by mouse 15min internal cause pain.As a result such as the following table 3.
The influence of 3 Chinese medicine composition Dichlorodiphenyl Acetate induced pain small white mouse writhing number of table
| Group | Writhing number (secondary) |
| Blank control group | 25 |
| Positive controls | 15 |
| Test group low dose group | 23 |
| Test group middle dose group | 19 |
| Test group high dose group | 12 |
The result shows that the middle and high dosage group of the Chinese medicine composition provided by embodiment 3 can significantly inhibit acetic acid induced pain mouse
The increase of writhing number.
4th, clinical test
1) to the therapeutic effect of rheumatic and rheumatoid disease
Randomly select 300 rheumatism, rheumatoid patients, wherein man, female it is fifty-fifty, above-mentioned patient is divided into 10 groups, blank pair
According to group, positive controls and test group, every group of each 30 people.Wherein, test group：1-5 of embodiment of the present invention offers are provided respectively
Chinese medicine composition or each 25mg of pill, 3 times a day；Blank control group：Take the physiological saline of equivalent；Positive controls：Mouthful
Take Voltarol enteric coatel tablets, each 25mg, 3 times a day；Experimental result was observed and recorded when 30 days, 60 days, 90 days, as a result
Such as the following table 4.
Efficacy assessment standard：It cures, refers to that clinical symptoms are substantially reduced or disappear, and without recurrence at 90 days；
Effective, above-mentioned clinical symptoms have a degree of mitigation or improvement when referring to 90 days；
In vain, refer to that above-mentioned clinical symptoms are without improvement or effect unobvious at 90 days.
4 Chinese medicine composition of table is to rheumatism, the therapeutic effect of atrophic diseases
The result shows that the Chinese medicine composition and preparation that are provided by embodiment 2,5 have preferably rheumatism, atrophic diseases
Therapeutic effect.Total effective rate may be up to 86.7% (total effective rate=(healing+effective)/sum * 100%).
2) to the therapeutic effect of apoplexy and apoplexy sequelae
Apoplexy or the patient 270 with apoplexy sequelae symptom are randomly selected, above-mentioned patient is divided into 9 groups, every group each
30 people.Take Chinese medicine composition that 1-6 of the embodiment of the present invention and comparative example 1,2 provide or pill each 25mg respectively, daily 3
It is secondary.Control group：Oral normal saline；Experimental result was observed and recorded when 30 days, 60 days, 90 days, it is as a result as follows
Table 5.
Wherein, patient screening standard：Patient has the symptoms such as hemiplegia, facial paralysis, slurred speech, four limbs are stiff.
Efficacy assessment standard：
Effectively refer to that patient clinical symptom is substantially reduced or fully recovers；
Refer to that the clinical symptoms of patient are without any improvement in vain.
5 Chinese medicine composition of table is to the therapeutic effect of apoplexy and apoplexy sequelae
The result shows that Chinese medicine composition and its pill that the application provides improve significantly to apoplexy and apoplexy sequelae
Effect, it is efficient up to more than 90%.
Only illustratively, the scope of the present invention is not limited thereto for above-described embodiment.To those skilled in the art
Modify for member is it will be apparent that the present invention is only limited by attached rights require scope.
Claims (5)
1. a kind of Chinese medicine composition with wind and relieving paralysis effect of dispelling, is made of each bulk pharmaceutical chemicals of following parts by weight：
10-25 parts of geranium wilfordii, 10-25 parts of caulis piperis futokadsurae, 10-25 parts of the root of Chinese clematis, 10-25 parts of Radix Astragali, 10-20 parts of Radix Angelicae Pubescentis, Ramulus Taxilli
10-20 parts, 10-20 parts of pawpaw is 10-20 parts windproof, 10-20 parts of Rhizoma Et Radix Notopterygii 10-20 Fen , pig label grass, 10-20 parts of Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis 10-
15 parts, 10-15 parts of safflower, 10-15 parts of Chinese cassia tree.
2. Chinese medicine composition according to claim 1, be made each bulk pharmaceutical chemicals geranium wilfordii of the Chinese medicine composition, Radix Astragali,
Caulis piperis futokadsurae, the root of Chinese clematis, Radix Angelicae Pubescentis, Ramulus Taxilli, pawpaw, windproof, Rhizoma Et Radix Notopterygii, pig label grass, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, safflower and Chinese cassia tree weight ratio
It is 5:5:5:4:3:4:3:3:4:3:3:3:2:2.
3. a kind of preparation with wind and relieving paralysis effect of dispelling comprising claim 1-2 any one of them Chinese medicine compositions, is
One kind in pill, particle, syrup, capsule and tablet.
4. preparation according to claim 3 is pill.
5. a kind of method for preparing the Chinese medicine composition with wind and relieving paralysis effect of dispelling as described in claim 1-2, specific to walk
It is rapid as follows：
1）Weigh each bulk pharmaceutical chemicals by weight, after crushing, respectively by geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, caulis piperis futokadsurae, the root of Chinese clematis,
Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii cross 10-50 mesh and sieve to obtain coarse powder；Pawpaw, pig label grass, Radix Angelicae Sinensis, safflower, Chinese cassia tree cross 80-100 mesh sieve respectively
Obtain fine powder；
2）It adds in purified water after the coarse powder of geranium wilfordii, Radix Astragali, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae is mixed to decoct 1-3 times, 1-3 hours each, filtering
Merging filtrate afterwards is concentrated to give 25oC relative densities are the medicinal extract 1 of 1.1-1.36；
After caulis piperis futokadsurae, the root of Chinese clematis, Ramulus Taxilli, windproof, Rhizoma Et Radix Notopterygii coarse powder are mixed, the ethyl alcohol for being 55-75% with volume fraction oozes
It filters, collects 6-8 times of percolate, ethyl alcohol is recovered under reduced pressure, is concentrated to give 25oC relative densities are the medicinal extract 2 of 1.15-1.29；
3）By step 1）In fine powder obtained mixed with medicinal extract 1,2 up to Chinese medicine composition.
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Denomination of invention: Traditional Chinese medicinal composition with effects of expelling wind and relieving cold-aggravated arthralgia and preparation method thereof Effective date of registration: 20190318 Granted publication date: 20180612 Pledgee: Jilin rural commercial bank and Limited by Share Ltd Pledgor: Jilin Zixin Pharmaceutical Co., Ltd. Registration number: 2019220000006 |
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