CN1253002A - Anti-cold oral liquid and its preparing process - Google Patents

Abstract

An anti-cold oral liquid for treating pneumonia, upper respiratory tract infection, tonsillitis, pharyngitis, etc. is prepared from honeysuckle flower, scutellaria root, forsythia fruit, white sugar, menthol and 5% ethyl paraben as basic remedy. Its advantages include quickly taking its effect, good oral feeling, simple preparing process and low cost.

Description

Anti-cold oral liquid and production technology thereof

The present invention relates to a kind of flu medicine preparation, the cold oral liquid preparation of diseases such as pneumonia, upper respiratory tract infection, tonsillitis, cigarette inflammation and the heating that causes because of antibacterial and viral infection especially for treatment, pharyngalgia, cough, expectoration.

Flu is a kind of the most common and multiple disease.The medicine of treatment also has the number of chemical medicine except that the natural drugs such as Chinese herbal medicine that Chinese medicine is used.Medicine has effect though chemical drugs cures cold, but can produce some side effect, therefore the Chinese medicine product that has no side effect of good effect just enjoys people's favor, at present, the Chinese medicine oral liquid of treatment flu has certain effect as " antivirus oral liquid ", " SHUANGHUANGLIAN oral liquid " etc. for the treatment flu, but it is slow also to exist curative effect, the not fairly obvious deficiency that waits of curative effect.

Task of the present invention is: overcome the deficiencies in the prior art, the anti-cold oral liquid and the preparation technology thereof that provide that a kind of curative effect is fast, mouthfeel good, be easy to take, preparation technology are simple, cost is low.

Task of the present invention is to realize (weight portion) with following prescription:

Flos Lonicerae 117.65

Radix Scutellariae 147

Fructus Forsythiae 235.3

White sugar 200

Mentholum 1.0

5% ethyl hydroxybenzoate 20ml makes 1000ml

Its production technology is:

The weighing medical material is chosen clean impurity in full, and decocting three times filters, and is concentrated in right amount, adds white sugar, boils 30 minutes, filters, and adds on the filter material and boils distilled water to capacity, adds Mentholum and ethyl hydroxybenzoate, fill, and packing is promptly.

The technology of producing oral liquid of the present invention is:

Compared with prior art, the present invention has following advantage: curative effect is fast, and mouthfeel is good, is easy to take, and the simple and low price of preparation technology has no side effect through animal experiment and clinical trial certificate oral liquid of the present invention, determined curative effect, reliable.

The animal experiment of this oral liquid:

Experiment material:

1, experiment medicine: anti-cold oral liquid, experiment side provides, lot number;

2, laboratory animal: Kunming mouse, Heilongjiang University of Chinese Medicine's Experimental Animal Center

Experimental technique and effect;

1, antitussive experiment:

30 of Kunming mouses, body weight 18-20 gram, male and female dual-purpose, divide 3 groups at random, 10 every group, irritate stomach respectively and give anti-cold oral liquid, high dose 30ml/kg, low dose group 10ml/kg, capacity water such as matched group, once a day, continuous three days, behind the last medicine 30 minutes, by only Mus being put into glass bell jar, put into long 10cm from bell jar is suitable for reading, wide 1.5cm filter paper bar, drip 0.5ml ammonia above, airtight, the cough latent period of mice behind the observation suction ammonia, whenever change a Mus, change a filter paper bar, every all drips 0.5ml ammonia, and experimental result sees Table 1.

The antitussive action of table 1 anti-cold oral liquid (X ± SD)

Group	The example number	Dosage (g/kg)	Cough latent period (s)
				High dose	???10	????15	????162.38±26.65**
Low dosage	???10	????5	????114±19.08*
				Matched group	???10	????/	????90±27.41

With matched group than * P＜0.05 * * P＜0.01

T check between group: high low dose group antitussive effect all has the significance meaning, P＜0.01 and P＜0.05.

2, the experiment of eliminating the phlegm:

30 of Kunming mouses, body weight 18-20 gram, male and female dual-purpose, divide 3 groups at random, 10 every group, irritate stomach respectively and give anti-cold oral liquid, high dose group 30ml/kg, low dose group 10ml/kg, matched group equal-volume water, once a day, continuous three days, behind the last medicine 30 minutes, every Mus lumbar injection 0.5% phenol red solution 0.5ml, after half an hour, take off cervical vertebra and put to death mice, face upward the position and be fixed on the operation plate, cut off neck center skin, separate trachea, under larynx injection needle is inserted trachea, ligation is fixed, and draws 5% sodium bicarbonate solution 0.5ml with syringe, flushing respiratory tract three times, amount to flushing three times, totally nine times, each flushing liquor is put into test tube, with 722 grating spectrophotometer colorimetrics, experimental result sees Table 2.

The phlegm-dispelling functions of table 2 anti-cold oral liquid (X ± SD)

Group	The example number	Dosage (g/kg)	Phenol red output (ug)
				High dose	???10	????15	????2.99±1.00**
Low dosage	???10	????5	????1.94±0.68*
				Matched group	???10	????/	????1.23±0.55

With matched group than *＜0.05 * * P＜0.01

T check between group: high low dose group is eliminated the phlegm all significance meaning P＜0.01 and P＜0.05

Experiment conclusion:, confirm that anti-cold oral liquid has tangible cough-suppressing phlegm-dispelling functions by the relieving cough and expelling phlegm experiment.

Clinical verification:

Through Heilongjiang Prov. Electric Power Hospital's clinical verification, serve as that the contrast medicine is observed 150 routine patients with " SHUANGHUANGLIAN oral liquid ":

The nature situation sees Table one, and the group of taking medicine is with single clothes anti-cold oral liquid, three-four times on the one, a 10-40ml (deciding) according to the age difference, matched group can be according to other multiple medicine of the conventional clothes of the state of an illness in order to judge the time limit in three days, its observation situation saw Table two in order to judge the time limit in three days.

Table one

Natural situation	The group of taking medicine	Matched group
			The man	????65	????70
The woman	????85	????80
			3～6 years old	????32	????28
7～14 years old	????25	????34
			15～60 years old	????75	????74
More than 60 years old	????18	????14

Table two

	Take medicine and organize remission or disappearance number	Matched group remission or disappearance number
			Sneeze	????100	????90
Nasal obstruction	????130	????100
			Watery nasal discharge	????150	????142
Hoarseness	????120	????96
			Cough	????146	????120
Fear of cold	????108	????100
			Headache	????102	????100

Its healing situation sees Table three.

Criterion: the three days clinical symptoms of taking medicine are partly alleviated and are produce effects, and the three days clinical symptoms of taking medicine disappearance person substantially are recovery from illness.

Table three

	The group of taking medicine	Matched group
			Produce effects	????24	????34
Recovery from illness	????114	????95
			Invalid	????12	????21
Total effective rate %	????92	????86

Discuss:

1, anti-cold oral liquid is the plus-minus side of SHUANGHUANGLIAN oral liquid, reuses the fourth Radix Scutellariae in the side, to increase the effect of clearing away lung-heat, detoxicating, relieving inflammation, join again through the Herba Menthae relieving the exterior syndrome with drugs of pungent in flavor and cool in nature in the full side, and wind and heat dispersing, detoxifcation is reduced phlegm, and has more increased former side's therapeutical effect.

2, Herba Menthae brain-capacity dispelling wind reduces phlegm, the important component menthol of Mentholum has certain therapeutical effect to respiratory inflammation, because it smells sense of taste feel Secondary cases, thereby has promoted endotracheal secretion, remove the mucus of adhering on the trachea, and reached the effect of eliminating the phlegm so that treating; In addition, menthol can make people that a kind of sense of euphoria and happy sense are arranged to the stimulation of trachea throat, is beneficial to very much the subjective symptoms of ease people.

3,, and the effect of preventing cold is arranged according to clinical observation anti-cold oral liquid curative effect the best at the initial stage of a disease.

The mechanism of curing the disease of the present invention is:

This prescription is made up of Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae, Mentholum, is monarch drug with the Radix Scutellariae in the side, lets out excess-fire, removes damp and hot; Flos Lonicerae, Fructus Forsythiae are ministerial drug, heat-clearing and toxic substances removing; Mentholum is an adjuvant drug; Radix Scutellariae is specialized in the part of the body cavity above the diaphragm housing the heart and lungs and is gone into lung meridian, lets out scorching detoxifcation, for controlling the key medicine of pathogenic fire in the lung; Wind-fire is damp and hot in the clear network of Flos Lonicerae, and eliminating carbuncle looses malicious, and the pathogenic factor in the exterior that looses thoroughly is the key medicine of detoxifcation; Fructus Forsythiae gas virtue is strong and property is refrigerant, and tool rises the power that floating a surname looses, and is the key medicine by wind heat, and three flavors share, and one clear one disappears one looses, and pathogenic fire reducing is eliminating evil, heat-clearing and toxic substances removing, and assistant is with Mentholum, and fragrance makes eye bright, the sore-throat relieving expectorant, the interior cardiopulmonary excess-fire of can letting out can make eye bright outward in moistening and cleaning throat.

Show according to modern data: Radix Scutellariae extract has antimicrobial spectrum more widely, G (+), G (-) bacterium is all had inhibitory action, and antiinflammatory refrigeration function etc. is arranged; Flos Lonicerae has tangible antibacterial action, and influenza virus is had deactivation, can also delay the pathological changes effect of Respirovirus pair cell; Fructus Forsythiae has broad-spectrum antibacterial action, simultaneously fungus, influenza virus, rhinovirus is had different inhibitory action, also has antiinflammatory action and analgesic town to tell effect etc.; Mentholum has certain diaphoresis, analgesic, antiinflammatory, is good for the stomach, function of gallbladder promoting and suppress the gastrointestinal smooth muscle contraction, and can increase the secretion of respiratory mucus, and reflexive have cough-relieving, a phlegm-dispelling functions.

The rule of treatment

Scorching method is let out in heat clearing away

A most preferred embodiment of the present invention is got Flos Lonicerae 117.65g, Radix Scutellariae 147g, Fructus Forsythiae 235.3g, white sugar 200g, Mentholum 1.0g, 5% ethyl hydroxybenzoate is an amount of.Above-mentioned medical material is chosen clean impurity, and decocting three times filters, and is concentrated in right amount, adds white sugar and boils 30 minutes, filters, and adds on the filter material and boils distilled water to capacity, adds Mentholum and ethyl hydroxybenzoate, makes the 1000ml anti-cold oral liquid, fill, and packing is finished product.

Claims (2)

1, a kind of anti-cold oral liquid is characterized in that: the prescription (weight portion) composed as follows of making this oral liquid:

Flos Lonicerae 117.65

Radix Scutellariae 147

Fructus Forsythiae 235.3

White sugar 200

Mentholum 1.0

5% ethyl hydroxybenzoate 20ml

Surplus is a water, makes 1000ml

2, a kind of processing technology of anti-cold oral liquid as claimed in claim 1, it is characterized in that: described each composition of weighing claim 1 in full, choose clean impurity, decocting three times, filter, be concentrated in right amount, add white sugar and boiled 30 minutes, filter then, add then and boil distilled water to capacity, add Mentholum and ethyl hydroxybenzoate, make 1000ml, last fill, packing.