CN1100945A - Broad spectrum detoxicating medicine for curing snakebite - Google Patents

Abstract

The present invention relates to a broad-spectrum detoxicating drug for treating snake-bite. It is made up by using ten traditional Chinese medicinal herbs of radical lobelia, hairy vein agrimony, honeysuckle flower, climbing groundsel, paris polyphilla, chrysanthemum flower, dandelion herb, viola philippica, bidens pilosa and centipede according to a scientific formulation. Said detoxicating drug not only can cure various snake-bites of blood circulation intoxication, mixed intoxication and neurotoxicosis, etc., but also has the advantages of notable curative effect and convenient application.

Description

Broad spectrum detoxicating medicine for curing snakebite

The present invention relates to a kind of broad spectrum detoxicating medicine for curing snakebite.

At present, the antidote for snake bites that is used for the treatment of snakebite has JIDESHENGSHEYAO (nantong sheyao) and " antivenin " (snake venom antibiotics), the former is only applicable to treat neural poison such as Agkistrodon halys, admixture poison snakebite (the heavy patient's curative effect to blood circulation poison class snakebites such as Agkistrodon acutus is not ideal), latter's can only " concentrate on one thing only " (which kind of snakebite which kind of antitoxic serum can only control), and must diagnose accurately, the early stage use can be taken effect.Yet China mountain area poisonous snake is of a great variety, because the restriction of conditions such as traffic, the various snakebite patients of remote mountain areas want in time to make a definite diagnosis nearby and suit the remedy to the case often to be difficult to accomplish.This just presses for provides a kind of easy to use, good effect, the antidote for snake bites of the various snakebites of energy extensively treating.

The objective of the invention is to provide a kind of broad spectrum detoxicating medicine for curing snakebite, and it not only has the significant curative effect of the various snakebites of treatment, and easy to use.

Design of the present invention is that employing Herba Lobeliae Chinensis (or Herba Cyathulae Prostratae), Rhizoma Paridis (or Radix et Rhizoma Dysosmatis), bidens pilosa (or Herba Hedyotidis Diffusae) and Herba Senecionis Scandentis are heat-clearing and toxic substances removing, the principal agent of inducing diuresis to remove edema: join Flos Lonicerae, Herba Taraxaci, Flos Chrysanthemi and Herba Violae grass to strengthen the effect of heat clearing away, detoxifcation; Join Herba Agrimoniae (or Herba Duchesneae Indicae) again in order to removing heat from blood, hemostasis; Join Scolopendra for detoxifcation, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.

The prescription of broad spectrum detoxicating medicine for curing snakebite of the present invention is:

Herba Lobeliae Chinensis (or Herba Cyathulae Prostratae) 23～30%

Herba Agrimoniae (or Herba Duchesneae Indicae) 5～10%

Flos Lonicerae 5～10%

Herba Senecionis Scandentis 5～10%

Paris polyphylla (or Radix et Rhizoma Dysosmatis) 2～5%

Flos Chrysanthemi 5～10%

Herba Taraxaci 5～10%

Herba Violae grass 5～10%

Bidens pilosa (or Herba Hedyotidis Diffusae) 5～10%

Scolopendra (or Herba pileae peploidis) 1～2%

Herba Lobeliae Chinensis in the prescription not only contains multiple alkaloid, flavonoid, Saponin, aminoacid etc., and diuresis, detoxifcation, excited respiratory center effect are arranged, the both available blood circulation poison class venom of controlling, and available again training the mind is through malicious class, admixture poison class venom.

Paris polyphylla contains flea body glycoside, aminoacid etc., heat-clearing and toxic substances removing is arranged, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., reducing swelling and alleviating pain and broad-spectrum antibacterial action.Be used for the treatment of the blood circulation poison class, neural malicious class admixture poison class venom all has better curative effect.

Herba Senecionis Scandentis, bidens pilosa, Herba Taraxaci, Herba Violae grass, Flos Lonicerae etc. contain flavonoid, alkaloid, glycoside etc. respectively, are extensive pedigree antibiotic, have heat-clearing toxin-expelling functions, and to blood circulation poison class venom, curative effect is rather good.

Herba Agrimoniae contains agrimonine, tannin etc., and antiinflammatory, anastalsis are arranged, and blood circulation poison class venom hemorrhage had inhibitory action.

Scolopendra contains the H-subst of similar Venenum apis and dissolved blood protein matter etc., and dispel the wind detoxifcation, anticonvulsant action are applicable to diseases such as convulsions due to the neural poison of treatment, the admixture poison snakebite, tic.

Because ten kinds of medicines in the above-mentioned prescription are combined into one in the science ratio, produced cooperative effect, so this broad spectrum detoxicating medicine for curing snakebite have heat-clearing and toxic substances removing, alleviating pain and detumescence, the remarkable function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. (analgesic, antibacterial, diuresis, calmness, convulsion) all has obvious curative effects to various snakebites such as the malicious class of nerve, blood circulation poison class and admixture poison classes.

Broad spectrum detoxicating medicine for curing snakebite of the present invention i.e. " Shaowu antidote for snake bites " is received better effects at the Fujian Shaowu City through the practical application of 208 examples.The comprehensive condition brief summary of clinical verification is as follows:

(1) physical data:

In 208 examples, man 147, women 61 examples: at minimum 3 years old of age, maximum 75 years old, between twenty and fifty 166 examples accounted for 80%; Peasant's 147 examples account for 70%; Student, workman, teacher, cadre and other people member's 61 examples account for 30%.The injured time with six, seven, eight, JIUYUE is maximum, according to the injured time of patient, place, finding poisonous snake form and the specimen of killing poisonous snake, in conjunction with life characteristic, mechanics and the clinical manifestation of the various poisonous snakes in the county, be diagnosed as that Agkistrodon is hindered 9 examples, Agkistrodon is hindered 22 examples, Trimeresurus stejnegeri snakebite 114 examples, Trimeresurus mucrosquamatus (Cantor). snakebite 26 examples, glasses snakebite 10 examples.3 examples are hindered by Dermis Enhydris chinensis, not clear snakebite 24 examples.The injury is in foot person 103 examples, ankle person 49 examples, shank person 10 examples, thigh person 1 example, finger person 26 examples, wrist person's 16 examples, ancon person 1 example, shoulder arm person 1 example, head person 1 example.208 routine patients judge by the sick and wounded situation grade scale of poisonous snake that national snakebite meeting in 1973 is formulated: light-duty 94 examples, medium-sized 103 examples, heavy 10 examples, danger type 1 example.

Two, cardinal symptom:

208 examples all have typical case and very not typical snakebite vestige.Except that bite local non-evident sympton and whole body of 9 routine Agkistrodon, 3 routine Dermis Enhydris chinensiss occurs the poisoning symptom, all there are obvious pain, swelling in all the other 196 routine parts.Wherein swelling surpasses more than the big joint, and two following person's 58 examples in big joint surpass two big joint person 97 examples, and 15 routine Agkistrodon wounds and part Trimeresurus stejnegeri, Trimeresurus mucrosquamatus (Cantor)., Naja the wounded see in various degree hemorrhage of subcutaneous and wound.11 examples are heavy, the danger type wounded are hemorrhage with mouth and nose, gingival hemorrhage, hematuria, have blood in stool.There are 13 routine wound circumference that in various degree ulcer and infection are arranged.Also has quite a few patient with different poisoning symptoms.Mainly show as uncomfortable in chest, dyspnea, hyperpyrexia, have a dizzy spell, laryngopharynx swelling and pain, have in addition shock.

Three, medicine is formed and Therapeutic Method:

Shaowu antidote for snake bites is made with ten kinds of Chinese herbal medicine pulverizing tablettings such as bidens pilosa, Radix et Rhizoma Dysosmatis, Herba Duchesneae Indicae, Herba Cyathulae Prostratae, Scolopendras, and every contains crude drug 0.5 gram.

Treatment is integrated as principle with Orally taken and externally " Shaowu antidote for snake bites ", reaches especially heavily external application of light, medium-sized patient in early days.Each 6 for oral administration, every day 3 times.Double first, child's dose cuts down according to the circumstance.External: with " Shaowu antivenom tablet is ground into powder and transferred vinegar or cold boiled water to be coated with the affected part.Every day 1-2 time, along with the alleviation of poisoning symptom after the medication, oral and external dose is decrement progressively.

Four, therapeutic outcome:

Disappear with the whole body poisoning symptom, local swelling is disappeared, and the wound healing that festers is a criterion of cure, in 208 examples, invalid 1 example, all the other are all cured, the shortest 1 day of period of healing, the longest 20 days, average 5.55 days, cure rate reached 99.5%, and not seeing during the treatment has any reflection.

Five, model case introduction:

1, the sick and wounded example of admixture poison poisonous snake

Old * *, woman, 26 years old.Shaowu diversified farm worker, 12 of JIUYUE in 1980 26 days are permitted on the way by the Naja outer ankle of left foot that bites, local severe pain, swelling.At that time please herbalist among the people treat 2 days, failed the disease controlling development, sent herbalist out-patient department diagnosis and treatment in Shaowu county institute of Pharmaceutical Research at 5 on 28 afternoon of JIUYUE.

Check: critical sickly complexion, and color is pale, staring spells, blurred vision.The bilateral blepharoptosis, platycoria, it is blunt to reflect, and suffers from limb and being dispersed in property of atropurpureus ecchymosis occurs.37.2 ℃ of body temperature, pulse is heavy thin, 84 times/minute, breathes 28 times/minute.Blood pressure 94/60 millimetres of mercury is hindered the swelling of limb severe, spreads to thigh root, and than 6 centimeters of strong side enlargements, wound blackout, numbness, pain.

Diagnosis: right lower extremity Naja bite (heavy type).

Treatment: promptly give clothes " Shaowu antidote for snake bites " 12, advise obeyed 6 night, grind into powder with " Shaowu antidote for snake bites " 20 in addition and transfer cold water to be coated on wound circumference every four hours, spirit took a turn for the better in second day, swelling also sees and disappears, but occur having blood in stool, hematuria, cardio palmus shape, facial, abdominal muscles has the twitch phenomenon.For oral administration, the liniment consumption is the same, and caves such as pass, tsu san li add the cooling blood for hemostasis Chinese herbal medicine in the acupuncture.

Through above-mentioned treatment seven days, the whole body poisoning symptom disappeared, and local swelling is disappeared substantially, leaves hospital morning October 5.

2, the sick and wounded example of blood circulation poison poisonous snake

Deng * *, the man, 9 years old, hole people from production team all thanked under the group in Shaowu Xian Shuibei people's commune two.Student, patient cut firewood on the mountain at 4 in afternoon on August 27th, 1980 and are carried on the back by the venom left hand, see Serpentis body green, five cun long of about chis.Hinder back wound causalgia, swelling was once used medical herbs external application wound rapidly to vertical spread after one hour, and 11 o'clock the next mornings are to the treatment of Shaowu county institute of Pharmaceutical Research out-patient department.

During prescription on individual diagnosis.Patient's coma, delirium, platycoria, it is blunt to reflect, 38.6 ℃ of body temperature.Pulse 140 times/minute is breathed 28 times/minute, and blood pressure 127/80 millimetres of mercury, wound are " ∴ " shape.Blister is nearly surplus in the of 20, and is big as egg, little of Semen Glycines, suffers from limb and the blood stasis point occurs.Be swelling to the shoulder arm, than 7 centimeters of strong side enlargements, thoracic dorsal has slightly and swells and ache.Family members Dai Shu only urinated once in one day, and urine quantity not sufficient 300CC is yellow redness of the skin or complexion.

Diagnosis: left hand back of the body Trimeresurus stejnegeri bite (heavy type).

Treatment: " Shaowu antidote for snake bites " 10 for oral administration, three times on the one.Wound circumference is coated with " Shaowu antidote for snake bites " (transferring cold boiled water) outward, afternoon staring spells, dyspnea, other obeys 6 of LIUSHEN WAN.

August 29, swelling still has development, to abdominal part, waist.Water, bleeding blister increase increase, urinate 2 times, and be short red.Continue to take " Shaowu antidote for snake bites ", one day three times, each 6.Big blister is needled, and is coated with " Shaowu antidote for snake bites " (accent vaseline) outward.

August 30, patient's mind is clear, asks and can answer, and One's heart is filled with pain in readme.Swelling place of breast abdominal part is soft, spreads to lower abdomen, can take food, and it is clear that urine changes, and amount increases, and treats the same.

August 31, uncomfortable in chest, the cardio palmus shape alleviates, and swelling is obviously disappeared, most of water bleeding blisters absorb, diet is normal, continues treatment three days, and General Symptoms disappears, swelling retreats to the back of the hand, suffer from the limb activity freely, the patient head of a family requires to leave hospital, and advises and continues to be coated with " Shaowu antidote for snake bites " or soak ethacridine gauze 1-2 days outward.

3, the sick and wounded example of neural poisonous snake

Post * *, the man, 27 years old, Shaowu Shui Bei Pu of people's commune people that founds the team, the peasant, about 9 o'clock evenings on the 14th of August in 1981 on the path of limit, field by the venom left lower extremity, it is white that the patient sees on this ichthyosis a joint Bai Yijie clearly by torch, the ring-type Serpentis.After half an hour, conscious trouble limb wound circumference is numb slightly, dizzy, dim eyesight, and pharyngalgia, whole body is aching and limp, and is drowsiness etc.After 2 hours, to Shaowu institute of Pharmaceutical Research out-patient treatment, 37.6 ℃ of body temperature, pulse is floating thin, breathes 28 times/minute, and blood pressure 110/70 millimetres of mercury wound is not red, pneumonedema, not bitterly.

Diagnosis: Agkistrodon bite (medium-sized)

Treatment: promptly give clothes " Shaowu antidote for snake bites " 8.Advise every six hours and take medicine once, each 4, transfer cold boiled water to be coated with wound circumference " Shaowu antidote for snake bites " levigation in addition, second day morning, poisoning symptom disappeared substantially, advised continuous clothes " Shaowu antidote for snake bites " 1 day, and three times, each 4.

Six, explanation

1, Shaowu antidote for snake bites " take to take orally, external application for curing snakebite effect is preferable.(making tablet, every 0.5 gram) for oral administration grasps general each 4-8 sheet, every day 3 times flexibly according to snakebite poisoning symptom weight; Can suitably increase dosage for indivedual critical patients, each 8-16 sheet, every day 4 times; External application is then transferred cold boiled water with the medicine levigation, is applied to wound circumference.Simultaneously, must note cooperating western medical treatment, to improve cure rate.

2, the great advantage of " Shaowu antidote for snake bites " is that can extensively treating various poisonous snakes hinder, and to need not diagnosis be which kind of poisonous snake hinders, and no matter is early, middle and late phase disease, and good efficacy is all arranged.

3, " Shaowu antidote for snake bites " is easy to use, and economical and effective is not only treated various poisonous snakes and hindered, and can also treat acute and chronic pharyngitis, parotitis, and it is multiple sick and wounded that innominate toxic swelling, furuncle furuncle and phyma, bee venom are stabbed etc., the clinical application non-evident effect.

Claims (1)

1, a kind of broad spectrum detoxicating medicine for curing snakebite is characterized in that its prescription is:

Herba Lobeliae Chinensis (or Herba Cyathulae Prostratae) 23～30%

Herba Agrimoniae (or Herba Duchesneae Indicae) 5～10%

Flos Lonicerae 5～10%

Herba Senecionis Scandentis 5～10%

Paris polyphylla (or Radix et Rhizoma Dysosmatis) 2～5%

Flos Chrysanthemi 5～10%

Herba Taraxaci 5～10%

Herba Violae grass 5～10%

Bidens pilosa (or Herba Hedyotidis Diffusae) 5～10%

Scolopendra (or Herba pileae peploidis) 1～2%