CN111700952A - A Chinese medicinal quick-release dripping pill for treating venomous snake bite, and its preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine quick-release dropping pill for treating venomous snake bite and a preparation method thereof, belonging to the technical field of preparation of traditional Chinese medicines for relieving snake venom. The quick-release traditional Chinese medicine dropping pill is prepared from the following raw materials in parts by weight: 20-25 parts of isochoria trema, 25-30 parts of stinkbug extract, 10-15 parts of hedyotis diffusa, 10-15 parts of paris polyphylla, 10-15 parts of humifuse euphorbia herb, 10-15 parts of philippine violet herb, 10-15 parts of dandelion and 10-15 parts of auxiliary materials; wherein the adjuvants comprise polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407. The composition can promote recovery of liver and kidney functions of poisoning, enhance toxin expelling and detoxifying functions of organisms, and also contains components which are obvious and durable in defecation and urination promotion, protect the liver and promote recovery of toxic liver cells.

Description

A Chinese medicinal quick-release dripping pill for treating venomous snake bite, and its preparation method

Technical Field

The invention relates to a traditional Chinese medicine quick-release dropping pill for treating venomous snake bite and a preparation method thereof, belonging to the technical field of preparation of traditional Chinese medicines for relieving snake venom.

Background

The disease after the poisonous snake bite is caused by the snake venom secreted from the venom gland, mainly comprising protein, polypeptide and various enzymes. Snake venom can be divided into neurotoxin and blood toxin, the former has damage effect on central nerve, peripheral nerve, and nerve muscle conduction function, and can cause convulsion, paralysis and respiratory paralysis; the latter causes damage to the cardiovascular and blood systems, causing arrhythmias, circulatory failure, hemolysis and bleeding. Mainly seen in rural areas in the south of China, mountain areas and summer and autumn, the diseases are more, and the common vipers comprise phyllostachys scaber, viper, bungarus fasciatus, bungarus multicinctus, viper, cobra, king cobra and agkistrodon acutus.

After being bitten by the poisonous snake, the speed and the severity of symptoms of a patient have an obvious relationship with the species of the poisonous snake and the dosage and the property of the poisonous snake, the bitten part, the depth of a wound and the resistance of the patient also have certain influences, when the poisonous snake actively hurts the patient in a hunger state, the toxin expelling amount is large, the consequence is serious, the on-site first aid after the poisonous snake bite is very important, various measures are adopted to quickly expel the poison and prevent the absorption and the diffusion of the venom, and after reaching a conditional medical station, comprehensive measures such as thorough debridement, effective snake tablets for oral administration and external application, the application of anti-snake venom serum and the whole body support therapy are continuously adopted.

The understanding of the traditional Chinese medicine on snake venom is recorded in the Suibian generation's theory of pathogenesis early, the main serum treatment for the first aid of snake bite poisoning is carried out by the anti-snake venom serum, the anti-snake venom serum has certain curative effect on the snake bite, the curative effect of the monovalent serum reaches 90%, but the curative effect of the polyvalent serum is only 50%, but the serum treatment only aims at one snake bite, the anti-snake venom is only used in the first aid period, the carrying and the use are inconvenient, the production period is long, the price is high, and meanwhile, the snake venom in different areas has certain difference and has different curative effects, so the method has certain difficulty in popularization.

Disclosure of Invention

The invention relates to a traditional Chinese medicine quick-release dropping pill for treating venomous snake bite, which is prepared from the following raw materials in parts by weight: 20-25 parts of isochoria trema, 25-30 parts of stinkbug extract, 10-15 parts of hedyotis diffusa, 10-15 parts of paris polyphylla, 10-15 parts of humifuse euphorbia herb, 10-15 parts of philippine violet herb, 10-15 parts of dandelion and 10-15 parts of auxiliary materials; wherein the adjuvants comprise polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407.

Preferably, the preparation method of the stinkbug extract comprises the following steps: slowly drying the stinkbug, then crushing, adding the crushed stinkbug into ethanol according to the proportion of 200-300 g/L, carrying out flash extraction for 2-3 times, extracting for 5-6min each time, filtering, heating the extracting solution, recovering the solvent, and drying at 60 ℃ to constant weight to obtain a dry extract A.

The invention also aims to provide a preparation method of the traditional Chinese medicine quick-release dropping pill for treating venomous snake bite, which comprises the following steps:

(1) weighing isochoria trema, hedyotis diffusa, paris polyphylla, humifuse euphorbia herb, Chinese violet herb and dandelion according to a proportion, crushing, sieving with a 20-mesh sieve, adding into 2-3 times of water by volume, decocting for 1-2 hours at 90-100 ℃, filtering after the decoction is finished, decocting for 1-2 times again, combining filtrates, adding ethanol with the mass percentage concentration of 60-70%, stirring while adding until the generated precipitate is not increased any more, then filtering, and drying the liquid at 60 ℃ to constant weight to obtain a dry extract B;

(2) weighing polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407, heating, melting, mixing, adding dry extract A and dry extract B, stirring, heating, keeping the temperature, placing into a dripping liquid chamber of a dripping pill machine, dripping into condensate, condensing into pills, cooling completely, taking out the dripping pills, removing liquid paraffin adhered to the surface, and drying in a vacuum drying oven for 24 h.

Preferably, the mass ratio of the polyethylene glycol 4000 to the polyethylene glycol 6000 to the poloxamer 407 is 3-4: 4-5: 0.4-0.5.

The invention has the beneficial effects that:

the Chinese medicinal quick-release dropping pill for treating venomous snake bite improves microcirculation, promotes recovery of liver and kidney functions of poisoning, enhances the functions of expelling toxin and detoxifying of organisms, and also contains components which are obvious and durable in relaxing bowels, protect the liver and promote recovery of toxic liver cells through scientific compatibility. The Chinese medicine is the fundamental treatment rule of expelling toxin by expelling heat and toxin, clearing ying and cooling blood, and promoting diuresis.

The traditional Chinese medicine composition is prepared into the quick-release dropping pill, has the advantages of high bioavailability, quick release, quick effect, small toxic and side effect and convenient use and carrying, and can be simultaneously taken orally and applied to wounds.

Detailed Description

The present invention is further described in detail with reference to the following specific examples, but the scope of the present invention is not limited to the above description.

Example 1

A traditional Chinese medicine quick-release dropping pill for treating venomous snake bite is prepared from the following raw materials in parts by weight: 20 parts of isochoria trema, 25 parts of stinkbug extract, 10 parts of hedyotis diffusa, 13 parts of paris polyphylla, 15 parts of humifuse euphorbia herb, 13 parts of Chinese violet, 10 parts of dandelion and 10 parts of auxiliary materials; wherein the adjuvants comprise polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407.

The preparation method of the traditional Chinese medicine quick-release dropping pill for treating venomous snake bite comprises the following steps:

(1) the preparation method of the stinkbug extract comprises the following steps: slowly drying the stinkbug, then crushing, adding the crushed stinkbug into ethanol according to the proportion of 200g/L, carrying out flash extraction for 2-3 times, extracting for 5min each time, filtering, heating the extracting solution, recovering the solvent, and drying at 60 ℃ to constant weight to obtain dry extract A.

(2) Weighing isochoria trema, hedyotis diffusa, paris polyphylla, humifuse euphorbia herb, Chinese violet herb and dandelion according to a proportion, crushing, sieving with a 20-mesh sieve, adding 2 times of water by volume, decocting for 1.5h at 95 ℃, filtering after the decoction is finished, decocting for 1 time again, combining filtrates, adding ethanol with the mass percentage concentration of 60%, stirring while adding until the generated precipitate is not increased any more, then filtering, and drying the liquid at 60 ℃ to constant weight to obtain dry extract B.

(3) Weighing polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407, heating, melting, mixing uniformly (the mass ratio of polyethylene glycol 4000 to polyethylene glycol 6000 to poloxamer 407 is 4:5:0.5), adding dry extract A and dry extract B, stirring uniformly, heating, keeping the temperature, placing into a dripping chamber of a dripping pill machine, dripping condensate into the dripping chamber, condensing the dripping chamber into pills, taking out the dripping pills after the dripping pills are completely cooled, removing liquid paraffin attached to the surfaces of the dripping pills, and drying in a vacuum drying oven for 24h to obtain the final product.

Example 2

A traditional Chinese medicine quick-release dropping pill for treating venomous snake bite is prepared from the following raw materials in parts by weight: 23 parts of isochorima mollissima, 28 parts of stinkbug extract, 13 parts of spreading hedyotis herb, 10 parts of paris polyphylla, 10 parts of humifuse euphorbia herb, 15 parts of Chinese violet, 13 parts of dandelion and 13 parts of auxiliary materials; wherein the adjuvants comprise polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407.

The preparation method of the traditional Chinese medicine quick-release dropping pill for treating venomous snake bite comprises the following steps:

(1) the preparation method of the stinkbug extract comprises the following steps: slowly drying the stinkbug, then crushing, adding the crushed stinkbug into ethanol according to the proportion of 300g/L, carrying out flash extraction for 3 times, extracting for 6min each time, filtering, heating the extracting solution, recovering the solvent, and drying at 60 ℃ to constant weight to obtain dry extract A.

(2) Weighing isochoria trema, hedyotis diffusa, paris polyphylla, humifuse euphorbia herb, Chinese violet herb and dandelion according to a proportion, crushing, sieving with a 20-mesh sieve, adding into water with the volume of 3 times, decocting for 1h at 100 ℃, filtering after the decoction is finished, decocting for 2 times again, combining the filtrates, adding ethanol with the mass percentage concentration of 70%, stirring while adding until the generated precipitate is not increased any more, then filtering, and drying the liquid at 60 ℃ to constant weight to obtain a dry extract B.

(3) Weighing polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407, heating, melting, mixing uniformly (the mass ratio of polyethylene glycol 4000 to polyethylene glycol 6000 to poloxamer 407 is 4:4:0.5), adding dry extract A and dry extract B, stirring uniformly, heating, keeping the temperature, placing into a dripping chamber of a dripping pill machine, dripping condensate into the dripping chamber, condensing the dripping chamber into pills, taking out the dripping pills after the dripping pills are completely cooled, removing liquid paraffin attached to the surfaces of the dripping pills, and drying in a vacuum drying oven for 24h to obtain the final product.

Example 3

A traditional Chinese medicine quick-release dropping pill for treating venomous snake bite is prepared from the following raw materials in parts by weight: 25 parts of isochoria trema, 30 parts of stinkbug extract, 15 parts of hedyotis diffusa, 15 parts of paris polyphylla, 13 parts of humifuse euphorbia herb, 10 parts of Chinese violet, 15 parts of dandelion and 15 parts of auxiliary materials; wherein the adjuvants comprise polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407.

The preparation method of the traditional Chinese medicine quick-release dropping pill for treating venomous snake bite comprises the following steps:

(1) the preparation method of the stinkbug extract comprises the following steps: slowly drying the stinkbug, then crushing, adding the crushed stinkbug into ethanol according to the proportion of 250g/L, carrying out flash extraction for 3 times, extracting for 5min each time, filtering, heating the extracting solution, recovering the solvent, and drying at 60 ℃ to constant weight to obtain dry extract A.

(2) Weighing isochoria trema, hedyotis diffusa, paris polyphylla, humifuse euphorbia herb, Chinese violet herb and dandelion according to a proportion, crushing, sieving with a 20-mesh sieve, adding 2 times of water by volume, decocting for 2h at 90 ℃, filtering after the decoction is finished, decocting for 1 time again, combining the filtrates, adding ethanol with the mass percentage concentration of 65%, stirring while adding until the generated precipitate is not increased any more, then filtering, and drying the liquid at 60 ℃ to constant weight to obtain a dry extract B.

(3) Weighing polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407, heating, melting, mixing uniformly (the mass ratio of polyethylene glycol 4000 to polyethylene glycol 6000 to poloxamer 407 is 3:4:0.4), adding dry extract A and dry extract B, stirring uniformly, heating, keeping the temperature, placing into a dripping chamber of a dripping pill machine, dripping condensate into the dripping chamber, condensing the dripping chamber into pills, taking out the dripping pills after the dripping pills are completely cooled, removing liquid paraffin attached to the surfaces of the dripping pills, and drying in a vacuum drying oven for 24h to obtain the final product.

Example 4

The treatment method comprises the following steps: thoroughly debriding with 1:5000 potassium permanganate solution and 5% -10% saline water, cutting the wound in a '+' or '+ +' shape with the dental scar as the center after disinfection, gently massaging from near to far to make the residual snake venom flow out conveniently, and preventing the cut from being too deep to hurt blood vessels; then 5% -10% saline is used for cleaning the wound to enable blood to flow out, and the product is placed into cold boiled water to be applied to the periphery of the wound, and the dressing is changed once a day.

Simultaneously, the medicine is taken orally, 3-4 times in the first day (within 24 hours), 10-15 granules (each granule contains 30mg of medicine) are taken for the first time, 8-10 granules are taken each time, and the medicine is taken every 3-4 hours; 8-10 granules are taken for the second and third days, 3 times a day, 6 granules are taken for the fourth day, and 2 times a day until the swelling is completely subsided.

The curative effect standard is as follows:

and (3) curing: the general poisoning symptom disappears, the swelling of the affected limb basically subsides, the wound basically heals, and the limb function is recovered.

Results

25 cases of the group use the Chinese medicinal quick-release dropping pills in the embodiments 1 to 3 randomly, and the cure rate is 98 percent; the average treatment of the bungarus multicinctus bite is 4.5 days, the average treatment of the bungarus multicinctus bite is 6 days, and the average treatment of the cobra bite is 7 days.

Example 5

Patient, male, 50 years old, farmer; when mushrooms are picked up in mountains and bitten by the bungarus multicinctus carelessly, the mushrooms are bound by a belt automatically, a few drops of poisonous blood are expelled from the wound automatically, the patients can seek medical advice 3 hours after the wound, the medicines are soaked and washed by saline water and potassium permanganate solution, the cross-shaped incision is made to attract toxin expelling, the medicine in the external application example 1 is externally applied for three times every day, no red swelling is produced after 3 days of continuous application, and the patients are healed after 5 days.

Claims (4)

1. A traditional Chinese medicine quick-release dropping pill for treating venomous snake bite is characterized in that: the quick-release traditional Chinese medicine dropping pill is prepared from the following raw materials in parts by weight: 20-25 parts of isochoria trema, 25-30 parts of stinkbug extract, 10-15 parts of hedyotis diffusa, 10-15 parts of paris polyphylla, 10-15 parts of humifuse euphorbia herb, 10-15 parts of philippine violet herb, 10-15 parts of dandelion and 10-15 parts of auxiliary materials; wherein the adjuvants comprise polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407.

2. The Chinese medicinal quick-release dropping pill for treating venomous snake bite according to claim 1, which is characterized in that: the preparation method of the stinkbug extract comprises the following steps: slowly drying the stinkbug, then crushing, adding the crushed stinkbug into ethanol according to the proportion of 200-300 g/L, carrying out flash extraction for 2-3 times, extracting for 5-6min each time, filtering, heating the extracting solution, recovering the solvent, and drying at 60 ℃ to constant weight to obtain a dry extract A.

3. The preparation method of the Chinese medicinal quick-release dropping pill for treating venomous snake bite as claimed in claim 2, which is characterized by comprising the following steps:

(1) weighing isochoria trema, hedyotis diffusa, paris polyphylla, humifuse euphorbia herb, Chinese violet herb and dandelion according to a proportion, crushing, sieving with a 20-mesh sieve, adding into 2-3 times of water by volume, decocting for 1-2 hours at 90-100 ℃, filtering after the decoction is finished, decocting for 1-2 times again, combining filtrates, adding ethanol with the mass percentage concentration of 60-70%, stirring while adding until the generated precipitate is not increased any more, then filtering, and drying the liquid at 60 ℃ to constant weight to obtain a dry extract B;

(2) weighing polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer 407, heating, melting, mixing, adding dry extract A and dry extract B, stirring, heating, keeping the temperature, placing into a dripping liquid chamber of a dripping pill machine, dripping into condensate, condensing into pills, cooling completely, taking out the dripping pills, removing liquid paraffin adhered to the surface, and drying in a vacuum drying oven for 24 h.

4. The method for preparing the Chinese medicinal quick-release dropping pill for treating the venomous snake bite of claim 3 is characterized in that: the mass ratio of the polyethylene glycol 4000 to the polyethylene glycol 6000 to the poloxamer 407 is 3-4: 4-5: 0.4-0.5.