CN114028503A - Chinese and western medicine formula for treating allergic rhinitis and application - Google Patents
Chinese and western medicine formula for treating allergic rhinitis and application Download PDFInfo
- Publication number
- CN114028503A CN114028503A CN202111492548.9A CN202111492548A CN114028503A CN 114028503 A CN114028503 A CN 114028503A CN 202111492548 A CN202111492548 A CN 202111492548A CN 114028503 A CN114028503 A CN 114028503A
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- powder
- medicine
- chinese medicine
- western
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a Chinese and western medicine formula for treating allergic rhinitis and application thereof, wherein the formula comprises the following components: traditional Chinese and western medicines; the mass of each component is as follows: 2.45-2.55 g of traditional Chinese medicine and 1.302-1.552 g of western medicine; the traditional Chinese medicine is prepared by grinding herba schizonepetae, mint, divaricate saposhnikovia root, burdock root, fructus forsythiae, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed root and radix glycyrrhizae preparata into powder and mixing, and the prepared medicine is any one of pills, powder, paste, pellets or capsules; the traditional Chinese medicine and western medicine compound formula is adopted for treatment, the traditional Chinese medicine is a monarch drug, the western medicine is added, the side effect is small, the absorption is fast, the curative effect is good, the cure rate is high, the negative effects on children and old people are reduced, the traditional Chinese medicine has the effects of dispelling wind and heat, clearing heat and promoting the production of body fluid, moistening throat and detoxifying and relieving stuffy nose, is suitable for treating the spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and can effectively relieve the adverse symptoms of nasal itching, sneezing, eye itching and ear itching.
Description
Technical Field
The invention relates to the technical field of allergic rhinitis treatment, in particular to a Chinese and western medicine formula for treating allergic rhinitis and application thereof.
Background
Allergic rhinitis, refers to a non-infectious inflammatory disease of the nasal mucosa that is mainly released by IgE-mediated mediators and is involved with various immunocompetent cells, cytokines and the like after an atopic individual is exposed to an allergen. The requirements for this to occur are 3: specific antigen is the substance which causes the immune response of the organism; atopic individuals, so-called individual differences, allergic constitutions; the specific antigen meets both idiotypic individuals. Allergic rhinitis is a global health problem that can lead to many illnesses and loss of labor. At present, the treatment principle of allergic rhinitis is to avoid allergen exposure as much as possible, and western medicines are mainly used for treating allergic rhinitis by conditionally applying specific immunotherapy through reasonable use of antihistamines and glucocorticoids; the traditional Chinese medicine treatment needs different medicines according to the physique of a patient, for example, Yupingfeng can be eaten for qi deficiency, and Jinkui Shenqi pills can be eaten for kidney yang deficiency. However, most of the conventional treatments adopt western medicine formulas independently, the side effects are large, the negative effects on children and old people are particularly strong, the curative effect is poor, the cure rate is low, a few of the traditional Chinese medicine formulas adopt traditional Chinese medicine formulas, the impurity removal force in the preparation process is small, the impurities in the traditional Chinese medicine are difficult to remove, the extraction degree of the effective components is low, the useless components are large, the absorption of the effective components is influenced, in addition, the traditional Chinese medicine generally adopts a traditional drying mode, a complicated flow of firstly evaporating and then crushing is needed, time and labor are wasted, the drying efficiency is low, the preparation cost is high, the components of the traditional Chinese medicine are easy to lose in a large amount in a long-time evaporation process, and the curative effect of the formula is inevitably influenced.
Disclosure of Invention
The invention aims to provide a Chinese and western medicine formula for treating allergic rhinitis and application thereof, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the Chinese and western medicine formula for treating allergic rhinitis comprises the following components: traditional Chinese and western medicines; the mass of each component is as follows: 2.45-2.55 g of traditional Chinese medicine and 1.302-1.552 g of western medicine.
Preferably, the traditional Chinese medicine is prepared by grinding herba schizonepetae, mint, radix sileris, burdock root, fructus forsythiae, bamboo leaves, Chinese brake herb, cocklebur fruit, flos magnoliae, rhizoma phragmitis and radix glycyrrhizae preparata and mixing, and the prepared medicine is any one of pills, powder, ointment, pellets or capsules.
Preferably, the weight ratio of the herba schizonepetae, the mint, the divaricate saposhnikovia root, the burdock root, the weeping forsythia, the bamboo leaf, the Chinese brake herb, the siberian cocklour fruit, the magnolia flower, the reed root and the moxibustion licorice is 4: 2: 1: 2, respectively.
Preferably, the western medicine comprises 3 vitamin C tablets, 1-2 oxytetracycline tablets, 1 cyproheptadine tablet and 1 dexamethasone tablet, wherein each vitamin C tablet is 0.1g, each oxytetracycline tablet is 0.25g, each cyproheptadine tablet is 0.002g, and each dexamethasone tablet is 0.75 g.
Preferably, the traditional Chinese medicine preparation and the western medicine preparation are matched for use, oral treatment is carried out according to the disease condition degree, 1-2 times a day and 5-7 days are a treatment course.
Preferably, the preparation method of the Chinese and western medicine formula for treating allergic rhinitis comprises the following steps: step one, preparing materials; step two, pulverizing; step three, mixing; step four, extracting; step five, concentration; step six, sterilizing; step seven, drying; step eight, preparing a preparation; step nine, dispensing;
in the first step, respectively weighing 8 parts of herba schizonepetae, 8 parts of mint, 4 parts of radix sileris, 4 parts of burdock root, 4 parts of fructus forsythiae, 4 parts of bamboo leaf, 4 parts of pteris multifida, 1 part of cocklebur fruit, 1 part of flos magnoliae, 4 parts of rhizoma phragmitis and 4 parts of various traditional Chinese medicine decoction pieces for moxibustion, and keeping the traditional Chinese medicine decoction pieces for later use;
in the second step, the prepared herba schizonepetae, mint, divaricate saposhnikovia root, burdock root, fructus forsythiae, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and moxibustion licorice in the first step are respectively poured into a traditional Chinese medicine grinding machine with the rotation speed of 1200r/min and the grinding precision of 20 meshes, wall breaking and grinding are carried out to obtain powdery particles with uniform size, and then impurities are removed through a cyclone collector to respectively obtain herba schizonepetae powder, mint powder, windproof powder, burdock root powder, fructus forsythiae powder, bamboo leaf powder, Chinese brake herb powder, cocklebur fruit powder, flos magnoliae powder, reed root powder and moxibustion licorice powder;
in the third step, sequentially pouring the schizonepeta powder, the mint powder, the wind-proof powder, the burdock root powder, the fructus forsythiae powder, the bamboo leaf powder, the phoenix-tail fern powder, the cocklebur fruit powder, the magnolia flower powder, the reed rhizome powder and the moxibustion licorice powder obtained in the second step into a dry powder stirrer, stirring for 15min at the speed of 240r/min, and uniformly mixing to obtain medicinal powder;
in the fourth step, the medicinal powder obtained in the third step is poured into a hot reflux extractor, a proper amount of solvent is added, the solvent is any one of glucose injection and sodium chloride injection, the medicinal powder is dissolved in the solvent by using water temperature, the mixture is continuously refluxed for multiple times after being evaporated at 130 ℃ and condensed at 23 ℃, extraction is carried out through a separating funnel, inorganic phases are discarded, and organic phases are combined to obtain an extracting solution;
injecting the extracting solution obtained in the fourth step into an ultrafiltration membrane filter, filtering macromolecular solid solutes by using a hollow fiber ultrafiltration membrane, injecting into a reverse osmosis filter, and filtering micromolecular solid solutes by using a reverse osmosis membrane to obtain a concentrated solution;
in the sixth step, the concentrated solution obtained in the fifth step is put into a microwave sterilization cabinet, and the microorganisms such as bacteria, viruses and the like are sterilized by using 1000MHz microwave at the low temperature of 15 ℃ to obtain sterile liquid medicine;
in the seventh step, the sterile liquid medicine obtained in the sixth step is injected into a spray dryer, sprayed out at high speed by an atomizing nozzle and fully contacted with high-temperature hot gas, so that water is quickly vaporized and discharged to obtain the traditional Chinese medicine extract;
pouring the traditional Chinese medicine extract obtained in the step seven into a pharmaceutical machine, dividing into a plurality of parts, and preparing into pills, powder, ointment, pellets or capsules with predetermined patterns to obtain a traditional Chinese medicine preparation;
and in the ninth step, weighing 1.302-1.552 g of western medicines according to the mass, weighing 2.45-2.55 g of traditional Chinese medicines in the eighth step, and filling the medicines into a medicine package together.
The traditional Chinese medicine is a monarch drug, is matched with western medicines and is taken, has the effects of dispelling wind and heat, promoting the production of body fluid and clearing heat, moistening throat and detoxifying and freeing nasal orifices, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and effectively relieves adverse symptoms such as nasal itching, sneezing, eye itching, ear itching and the like.
Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine and western medicine formula for treating the allergic rhinitis and the application thereof adopt the compound traditional Chinese medicine and western medicine formula for treatment, the traditional Chinese medicine is monarch drug, the western medicine is added, the side effect is small, the absorption is quick, the curative effect is good, the cure rate is high, the negative effect on children and old people is reduced, the traditional Chinese medicine and western medicine formula has the effects of dispelling wind and heat, clearing heat and promoting the secretion of saliva or body fluid, moistening and detoxifying, and promoting nasal resuscitation, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and can effectively relieve the adverse symptoms of nasal itching, sneezing, eye itching and ear itching; the cyclone collection, the hot reflux extraction, the ultrafiltration membrane filtration and the reverse osmosis concentration are adopted, so that the impurity removal degree during preparation is improved, impurities in medicinal materials are greatly removed, the extraction degree of functional components is high, the content of useless components is low, and the absorption of the functional components is promoted; the spray drying method is adopted, the traditional evaporation and crushing processes are omitted, the time and the labor are saved, the drying efficiency is high, the water evaporation time is short, the medicine component loss of the traditional Chinese medicine is less, and the curative effect of the formula is ensured.
Drawings
FIG. 1 is a flow chart of the method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, the present invention provides a technical solution:
example 1:
the Chinese and western medicine formula for treating allergic rhinitis comprises the following components: traditional Chinese and western medicines; the mass of each component is as follows: 2.45g of traditional Chinese medicine and 1.302g of western medicine, wherein the traditional Chinese medicine is prepared by grinding and mixing schizonepeta, mint, divaricate saposhnikovia root, burdock root, weeping forsythia capsule, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and radix glycyrrhizae preparata, and is prepared into a patent medicine which is any one of pills, powder, ointment, red lead or capsules, wherein the weight ratio of the schizonepeta, the mint, the divaricate saposhnikovia root, the burdock root, weeping forsythia capsule, bamboo leaf, phoenix-tail fern, cocklebur fruit, flos magnoliae, reed root and the liquorice is respectively 4: 2: 1: 2, the western medicine comprises 3 pieces of vitamin C, 1 piece of oxytetracycline, 1 piece of heptidine and 1 piece of dexamethasone, 0.1g of vitamin C, 0.25g of oxytetracycline, 0.002g of cyproheptadine and 0.75g of dexamethasone per piece, the traditional Chinese medicine and the western medicine are matched with each other medicine for patient's condition, the patient's condition is treated by oral administration, the degree is 1.2, and the treatment course is 1 day, and the treatment course is 7-5 days, contraindications and cautionary matters refer to those of cyproheptadine and dexamethasone, and patients with allergic constitution containing Chinese and western medicinal components in the formula are prohibited to take the medicine, and patients who do not take the medicine need to take the medicine as soon as possible.
The preparation method of the Chinese and western medicine formula for treating allergic rhinitis comprises the following steps: step one, preparing materials; step two, pulverizing; step three, mixing; step four, extracting; step five, concentration; step six, sterilizing; step seven, drying; step eight, preparing a preparation; step nine, dispensing;
in the first step, respectively weighing 8 parts of herba schizonepetae, 8 parts of mint, 4 parts of radix sileris, 4 parts of burdock root, 4 parts of fructus forsythiae, 4 parts of bamboo leaf, 4 parts of pteris multifida, 1 part of cocklebur fruit, 1 part of flos magnoliae, 4 parts of rhizoma phragmitis and 4 parts of various traditional Chinese medicine decoction pieces for moxibustion, and keeping the traditional Chinese medicine decoction pieces for later use;
in the second step, the prepared herba schizonepetae, mint, divaricate saposhnikovia root, burdock root, fructus forsythiae, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and moxibustion licorice in the first step are respectively poured into a traditional Chinese medicine grinding machine with the rotation speed of 1200r/min and the grinding precision of 20 meshes, wall breaking and grinding are carried out to obtain powdery particles with uniform size, and then impurities are removed through a cyclone collector to respectively obtain herba schizonepetae powder, mint powder, windproof powder, burdock root powder, fructus forsythiae powder, bamboo leaf powder, Chinese brake herb powder, cocklebur fruit powder, flos magnoliae powder, reed root powder and moxibustion licorice powder;
in the third step, sequentially pouring the schizonepeta powder, the mint powder, the wind-proof powder, the burdock root powder, the fructus forsythiae powder, the bamboo leaf powder, the phoenix-tail fern powder, the cocklebur fruit powder, the magnolia flower powder, the reed rhizome powder and the moxibustion licorice powder obtained in the second step into a dry powder stirrer, stirring for 15min at the speed of 240r/min, and uniformly mixing to obtain medicinal powder;
in the fourth step, the medicinal powder obtained in the third step is poured into a hot reflux extractor, a proper amount of solvent is added, the solvent is any one of glucose injection and sodium chloride injection, the medicinal powder is dissolved in the solvent by using water temperature, the mixture is continuously refluxed for multiple times after being evaporated at 130 ℃ and condensed at 23 ℃, extraction is carried out through a separating funnel, inorganic phases are discarded, and organic phases are combined to obtain an extracting solution;
injecting the extracting solution obtained in the fourth step into an ultrafiltration membrane filter, filtering macromolecular solid solutes by using a hollow fiber ultrafiltration membrane, injecting into a reverse osmosis filter, and filtering micromolecular solid solutes by using a reverse osmosis membrane to obtain a concentrated solution;
in the sixth step, the concentrated solution obtained in the fifth step is put into a microwave sterilization cabinet, and the microorganisms such as bacteria, viruses and the like are sterilized by using 1000MHz microwave at the low temperature of 15 ℃ to obtain sterile liquid medicine;
in the seventh step, the sterile liquid medicine obtained in the sixth step is injected into a spray dryer, sprayed out at high speed by an atomizing nozzle and fully contacted with high-temperature hot gas, so that water is quickly vaporized and discharged to obtain the traditional Chinese medicine extract;
pouring the traditional Chinese medicine extract obtained in the step seven into a pharmaceutical machine, dividing into a plurality of parts, and preparing into pills, powder, ointment, pellets or capsules with predetermined patterns to obtain a traditional Chinese medicine preparation;
and step nine, weighing 1.302g of western medicines according to the mass, weighing 2.45g of traditional Chinese medicines in step eight, and filling the medicines into a medicine package together.
The traditional Chinese medicine is a monarch drug, is matched with western medicines and is taken, has the effects of dispelling wind and heat, promoting the production of body fluid and clearing heat, moistening throat and detoxifying and freeing nasal orifices, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and effectively relieves adverse symptoms such as nasal itching, sneezing, eye itching, ear itching and the like.
Example 2:
the Chinese and western medicine formula for treating the allergic rhinitis comprises the following components in parts by weight: traditional Chinese and western medicines; the mass of each component is as follows: 2.5g of traditional Chinese medicine and 1.302g of western medicine, wherein the traditional Chinese medicine is prepared by grinding and mixing schizonepeta, mint, divaricate saposhnikovia root, burdock root, weeping forsythia capsule, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and radix glycyrrhizae preparata, and is prepared into a patent medicine which is any one of pills, powder, ointment, red lead or capsules, wherein the weight ratio of the schizonepeta, the mint, the divaricate saposhnikovia root, the burdock root, weeping forsythia capsule, bamboo leaf, phoenix-tail fern, cocklebur fruit, flos magnoliae, reed root and the liquorice is respectively 4: 2: 1: 2, the western medicine comprises 3 pieces of vitamin C, 1 piece of oxytetracycline, 1 piece of heptidine and 1 piece of dexamethasone, 0.1g of vitamin C, 0.25g of oxytetracycline, 0.002g of cyproheptadine and 0.75g of dexamethasone per piece, the traditional Chinese medicine and the western medicine are matched with each other medicine for patient's condition, the patient's condition is treated by oral administration, the degree is 1.2, and the treatment course is 1 day, and the treatment course is 7-7 days, contraindications and cautionary matters refer to those of cyproheptadine and dexamethasone, and patients with allergic constitution containing Chinese and western medicinal components in the formula are prohibited to take the medicine, and patients who do not take the medicine need to take the medicine as soon as possible.
The preparation method of the Chinese and western medicine formula for treating allergic rhinitis comprises the following steps: step one, preparing materials; step two, pulverizing; step three, mixing; step four, extracting; step five, concentration; step six, sterilizing; step seven, drying; step eight, preparing a preparation; step nine, dispensing;
in the first step, respectively weighing 8 parts of herba schizonepetae, 8 parts of mint, 4 parts of radix sileris, 4 parts of burdock root, 4 parts of fructus forsythiae, 4 parts of bamboo leaf, 4 parts of pteris multifida, 1 part of cocklebur fruit, 1 part of flos magnoliae, 4 parts of rhizoma phragmitis and 4 parts of various traditional Chinese medicine decoction pieces for moxibustion, and keeping the traditional Chinese medicine decoction pieces for later use;
in the second step, the prepared herba schizonepetae, mint, divaricate saposhnikovia root, burdock root, fructus forsythiae, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and moxibustion licorice in the first step are respectively poured into a traditional Chinese medicine grinding machine with the rotation speed of 1200r/min and the grinding precision of 20 meshes, wall breaking and grinding are carried out to obtain powdery particles with uniform size, and then impurities are removed through a cyclone collector to respectively obtain herba schizonepetae powder, mint powder, windproof powder, burdock root powder, fructus forsythiae powder, bamboo leaf powder, Chinese brake herb powder, cocklebur fruit powder, flos magnoliae powder, reed root powder and moxibustion licorice powder;
in the third step, sequentially pouring the schizonepeta powder, the mint powder, the wind-proof powder, the burdock root powder, the fructus forsythiae powder, the bamboo leaf powder, the phoenix-tail fern powder, the cocklebur fruit powder, the magnolia flower powder, the reed rhizome powder and the moxibustion licorice powder obtained in the second step into a dry powder stirrer, stirring for 15min at the speed of 240r/min, and uniformly mixing to obtain medicinal powder;
in the fourth step, the medicinal powder obtained in the third step is poured into a hot reflux extractor, a proper amount of solvent is added, the solvent is any one of glucose injection and sodium chloride injection, the medicinal powder is dissolved in the solvent by using water temperature, the mixture is continuously refluxed for multiple times after being evaporated at 130 ℃ and condensed at 23 ℃, extraction is carried out through a separating funnel, inorganic phases are discarded, and organic phases are combined to obtain an extracting solution;
injecting the extracting solution obtained in the fourth step into an ultrafiltration membrane filter, filtering macromolecular solid solutes by using a hollow fiber ultrafiltration membrane, injecting into a reverse osmosis filter, and filtering micromolecular solid solutes by using a reverse osmosis membrane to obtain a concentrated solution;
in the sixth step, the concentrated solution obtained in the fifth step is put into a microwave sterilization cabinet, and the microorganisms such as bacteria, viruses and the like are sterilized by using 1000MHz microwave at the low temperature of 15 ℃ to obtain sterile liquid medicine;
in the seventh step, the sterile liquid medicine obtained in the sixth step is injected into a spray dryer, sprayed out at high speed by an atomizing nozzle and fully contacted with high-temperature hot gas, so that water is quickly vaporized and discharged to obtain the traditional Chinese medicine extract;
pouring the traditional Chinese medicine extract obtained in the step seven into a pharmaceutical machine, dividing into a plurality of parts, and preparing into pills, powder, ointment, pellets or capsules with predetermined patterns to obtain a traditional Chinese medicine preparation;
and step nine, weighing 1.302g of western medicines according to the mass, weighing 2.5g of traditional Chinese medicines in step eight, and filling the medicines into a medicine package together.
The traditional Chinese medicine is a monarch drug, is matched with western medicines and is taken, has the effects of dispelling wind and heat, promoting the production of body fluid and clearing heat, moistening throat and detoxifying and freeing nasal orifices, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and effectively relieves adverse symptoms such as nasal itching, sneezing, eye itching, ear itching and the like.
Example 3:
the Chinese and western medicine formula for treating the allergic rhinitis comprises the following components in parts by weight: traditional Chinese and western medicines; the mass of each component is as follows: 2.55g of traditional Chinese medicine and 1.552g of western medicine, wherein the traditional Chinese medicine is prepared by grinding and mixing schizonepeta, mint, divaricate saposhnikovia root, burdock root, weeping forsythia capsule, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and radix glycyrrhizae preparata into powder, and is prepared into a patent medicine which is any one of pills, powder, ointment, red lead or capsules, wherein the weight ratio of the schizonepeta, the mint, the divaricate saposhnikovia root, the burdock root, weeping forsythia capsule, bamboo leaf, phoenix-tail fern, the cocklebur fruit, flos magnoliae, the reed root and the radix glycyrrhizae preparata is 4: 2: 1: 2, the western medicine comprises 3 pieces of vitamin C, 2 pieces of oxytetracycline, 1 piece of heptidine and 1 piece of dexamethasone, 0.1.1 g of vitamin C, 0.002g of oxytetracycline, 0.75g of cyproheptadine and 0.75g of dexamethasone per piece, the traditional Chinese medicine and the western medicine are matched for patient's condition, the patient is treated by oral administration, the degree of the traditional Chinese medicine and the western medicine is 1.2 times per day, and the treatment course is 7-7 days, contraindications and cautionary matters refer to those of cyproheptadine and dexamethasone, and patients with allergic constitution containing Chinese and western medicinal components in the formula are prohibited to take the medicine, and patients who do not take the medicine need to take the medicine as soon as possible.
The preparation method of the Chinese and western medicine formula for treating allergic rhinitis comprises the following steps: step one, preparing materials; step two, pulverizing; step three, mixing; step four, extracting; step five, concentration; step six, sterilizing; step seven, drying; step eight, preparing a preparation; step nine, dispensing;
in the first step, respectively weighing 8 parts of herba schizonepetae, 8 parts of mint, 4 parts of radix sileris, 4 parts of burdock root, 4 parts of fructus forsythiae, 4 parts of bamboo leaf, 4 parts of pteris multifida, 1 part of cocklebur fruit, 1 part of flos magnoliae, 4 parts of rhizoma phragmitis and 4 parts of various traditional Chinese medicine decoction pieces for moxibustion, and keeping the traditional Chinese medicine decoction pieces for later use;
in the second step, the prepared herba schizonepetae, mint, divaricate saposhnikovia root, burdock root, fructus forsythiae, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and moxibustion licorice in the first step are respectively poured into a traditional Chinese medicine grinding machine with the rotation speed of 1200r/min and the grinding precision of 20 meshes, wall breaking and grinding are carried out to obtain powdery particles with uniform size, and then impurities are removed through a cyclone collector to respectively obtain herba schizonepetae powder, mint powder, windproof powder, burdock root powder, fructus forsythiae powder, bamboo leaf powder, Chinese brake herb powder, cocklebur fruit powder, flos magnoliae powder, reed root powder and moxibustion licorice powder;
in the third step, sequentially pouring the schizonepeta powder, the mint powder, the wind-proof powder, the burdock root powder, the fructus forsythiae powder, the bamboo leaf powder, the phoenix-tail fern powder, the cocklebur fruit powder, the magnolia flower powder, the reed rhizome powder and the moxibustion licorice powder obtained in the second step into a dry powder stirrer, stirring for 15min at the speed of 240r/min, and uniformly mixing to obtain medicinal powder;
in the fourth step, the medicinal powder obtained in the third step is poured into a hot reflux extractor, a proper amount of solvent is added, the solvent is any one of glucose injection and sodium chloride injection, the medicinal powder is dissolved in the solvent by using water temperature, the mixture is continuously refluxed for multiple times after being evaporated at 130 ℃ and condensed at 23 ℃, extraction is carried out through a separating funnel, inorganic phases are discarded, and organic phases are combined to obtain an extracting solution;
injecting the extracting solution obtained in the fourth step into an ultrafiltration membrane filter, filtering macromolecular solid solutes by using a hollow fiber ultrafiltration membrane, injecting into a reverse osmosis filter, and filtering micromolecular solid solutes by using a reverse osmosis membrane to obtain a concentrated solution;
in the sixth step, the concentrated solution obtained in the fifth step is put into a microwave sterilization cabinet, and the microorganisms such as bacteria, viruses and the like are sterilized by using 1000MHz microwave at the low temperature of 15 ℃ to obtain sterile liquid medicine;
in the seventh step, the sterile liquid medicine obtained in the sixth step is injected into a spray dryer, sprayed out at high speed by an atomizing nozzle and fully contacted with high-temperature hot gas, so that water is quickly vaporized and discharged to obtain the traditional Chinese medicine extract;
pouring the traditional Chinese medicine extract obtained in the step seven into a pharmaceutical machine, dividing into a plurality of parts, and preparing into pills, powder, ointment, pellets or capsules with predetermined patterns to obtain a traditional Chinese medicine preparation;
and step nine, weighing 1.552g of western medicine according to the mass, weighing 2.55g of traditional Chinese medicine from step eight, and filling the western medicine and the traditional Chinese medicine into a medicine bag.
The traditional Chinese medicine is a monarch drug, is matched with western medicines and is taken, has the effects of dispelling wind and heat, promoting the production of body fluid and clearing heat, moistening throat and detoxifying and freeing nasal orifices, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and effectively relieves adverse symptoms such as nasal itching, sneezing, eye itching, ear itching and the like.
The traditional Chinese medicine preparations obtained in the above examples are respectively subjected to functional component purity detection, and the obtained results are as follows:
| purity of functional component | |
| Example 1 | 98.9％ |
| Example 2 | 99.0％ |
| Example 3 | 99.0％ |
Based on the above, the traditional Chinese medicine and western medicine compound formula is adopted for treatment, the traditional Chinese medicine is a monarch drug, the western medicine is added, the side effect is small, the absorption is quick, the curative effect is good, the cure rate is high, the negative effects on children and old people are reduced, the traditional Chinese medicine has the effects of dispelling wind and heat, clearing heat and promoting the secretion of saliva or body fluid, moistening and detoxifying, and promoting nasal resuscitation, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and can effectively relieve adverse symptoms of nasal itching, sneezing, eye itching and ear itching.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (6)
1. The Chinese and western medicine formula for treating allergic rhinitis comprises the following components: traditional Chinese and western medicines; the method is characterized in that: the mass of each component is as follows: 2.45-2.55 g of traditional Chinese medicine and 1.302-1.552 g of western medicine.
2. The pharmaceutical formulation of claim 1, wherein the formulation comprises: the traditional Chinese medicine is prepared by grinding herba schizonepetae, mint, radix sileris, burdock root, fructus forsythiae, bamboo leaf, Chinese brake herb, cocklebur fruit, flos magnoliae, reed rhizome and radix glycyrrhizae preparata into powder and mixing, and the prepared medicine is any one of pills, powder, ointment, pellets or capsules.
3. The pharmaceutical formulation of claim 2, wherein the formulation comprises: the weight ratio of the herba schizonepetae, the mint, the divaricate saposhnikovia root, the burdock root, the weeping forsythia, the bamboo leaf, the Chinese brake herb, the siberian cocklebur fruit, the flos magnoliae, the reed root and the moxibustion licorice is 4: 2: 1: 2 respectively.
4. The pharmaceutical formulation of claim 1, wherein the formulation comprises: the western medicine comprises 3 pieces of vitamin C, 1-2 pieces of oxytetracycline, 1 piece of cyproheptadine and 1 piece of dexamethasone, wherein each piece of vitamin C is 0.1g, each piece of oxytetracycline is 0.25g, each piece of cyproheptadine is 0.002g, and each piece of dexamethasone is 0.75 g.
5. The pharmaceutical formulation of claim 1, wherein the formulation comprises: the traditional Chinese medicine preparation and the western medicine preparation are matched for use, and are orally taken for treatment according to the disease condition degree, 1-2 times a day and 5-7 days are a treatment course.
6. The traditional Chinese medicine is a monarch drug, is matched with western medicines and is taken, has the effects of dispelling wind and heat, promoting the production of body fluid and clearing heat, moistening throat and detoxifying and freeing nasal orifices, is suitable for treating spring and summer seasonal pollen allergic rhinitis patients in regions with dry climate and large temperature difference, and effectively relieves adverse symptoms such as nasal itching, sneezing, eye itching, ear itching and the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111492548.9A CN114028503A (en) | 2021-12-08 | 2021-12-08 | Chinese and western medicine formula for treating allergic rhinitis and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111492548.9A CN114028503A (en) | 2021-12-08 | 2021-12-08 | Chinese and western medicine formula for treating allergic rhinitis and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114028503A true CN114028503A (en) | 2022-02-11 |
Family
ID=80146472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111492548.9A Pending CN114028503A (en) | 2021-12-08 | 2021-12-08 | Chinese and western medicine formula for treating allergic rhinitis and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114028503A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660256A (en) * | 2004-12-31 | 2005-08-31 | 林定增 | Medication for treating cough caused by inflammation of upper respiratory tract |
| WO2020257390A1 (en) * | 2019-06-21 | 2020-12-24 | Evelo Biosciences, Inc. | Compositions and methods of treating a th2-mediated condition using prevotella |
| CN112336810A (en) * | 2019-08-07 | 2021-02-09 | 湖北清大中药饮片有限公司 | Pure traditional Chinese medicine preparation for treating allergic rhinitis |
-
2021
- 2021-12-08 CN CN202111492548.9A patent/CN114028503A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660256A (en) * | 2004-12-31 | 2005-08-31 | 林定增 | Medication for treating cough caused by inflammation of upper respiratory tract |
| WO2020257390A1 (en) * | 2019-06-21 | 2020-12-24 | Evelo Biosciences, Inc. | Compositions and methods of treating a th2-mediated condition using prevotella |
| CN112336810A (en) * | 2019-08-07 | 2021-02-09 | 湖北清大中药饮片有限公司 | Pure traditional Chinese medicine preparation for treating allergic rhinitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101099763A (en) | Traditional Chinese medicine for treating headache | |
| CN109223637B (en) | Compound traditional Chinese medicine subprostrate sophora toothpaste and preparation method thereof | |
| CN1210047C (en) | Medicine for treating common cold and preparation method | |
| KR20220098360A (en) | Forsythia-Astragalus peritoneal preparation and its manufacturing method and use | |
| CN104887952B (en) | Composition with yin nourishing and lung moistening effects and preparation method and application thereof | |
| CN102284022A (en) | Cough medicament and preparation method thereof | |
| CN108653434A (en) | A kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome | |
| CN104013929A (en) | Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof | |
| CN100500183C (en) | Preparation of Chinese medicinal mixture for treating gynecologic menstrual disease | |
| CN101085121A (en) | Traditional Chinese medicine composition with hypoglycemic and antilipemic function and making method and application | |
| CN114028503A (en) | Chinese and western medicine formula for treating allergic rhinitis and application | |
| CN1413697A (en) | Method for preparing Chinese medicine Liuwei Dihuang preparation | |
| CN1660260A (en) | Effervescence grains of reducing fever and relieving a cough for infant and preparation method | |
| CN1314434C (en) | Heat-clearing and detoxic medicine and its preparation method | |
| CN101084996A (en) | Traditional Chinese medicine containing red sage root and its preparation | |
| CN1060663C (en) | Compound Tibet capillary artemisia patent medicine | |
| CN112641855B (en) | A Chinese medicinal composition for treating or preventing common cold, and its preparation method | |
| CN112076276B (en) | Pharmaceutical composition for treating allergic rhinitis and preparation method thereof | |
| CN106511902A (en) | Preparation method for traditional Chinese medicine preparation for relieving swelling and pain | |
| CN102755519A (en) | Kudzuvine root-kudzuvine flower anti-canker sore particle and preparation method thereof | |
| CN107308275B (en) | Infantile common cold granules and preparation method thereof | |
| CN112168943A (en) | Traditional Chinese medicine composition and extract for preventing new coronary pneumonia, and preparation method and application thereof | |
| CN1063613A (en) | The preparation method of Yuquan capsule | |
| CN101085009A (en) | Composition containing barrenwort for treating cardiovascular diseases and its preparation | |
| CN105125682A (en) | Medicine preparation for treating facioplegia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220211 |
|
| RJ01 | Rejection of invention patent application after publication |