CN112168943A - Traditional Chinese medicine composition and extract for preventing new coronary pneumonia, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition and extract for preventing new coronary pneumonia, and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing neocoronary pneumonia, an extract, a preparation method and an application thereof. The traditional Chinese medicine composition comprises: 10-20 parts of honeysuckle, 10-20 parts of dandelion, 5-15 parts of houttuynia cordata, 5-15 parts of agastache rugosus, 5-15 parts of poria cocos, 5-15 parts of coix seeds, 4-8 parts of dried orange peel, 4-8 parts of mint, 4-8 parts of platycodon grandiflorum, 25-35 parts of fresh reed rhizome, 4-8 parts of ginger and 4-8 parts of Chinese dates. The traditional Chinese medicine composition and the extract thereof adopt components with homology of medicine and food, have more mild medicine property, and have better effects in the aspects of clearing heat, dispelling wind, clearing lung, detoxifying, expelling pathogenic factors, removing dirt, strengthening spleen, eliminating dampness, relieving cough, reducing phlegm and the like; according to the preparation method, through low-temperature extraction, low-temperature concentration and natural solidification, the extract of the prepared traditional Chinese medicine composition is loose powder with a certain granularity, so that the effective ingredients in the raw materials can be better reserved, and auxiliary materials are not required to be added for granulation.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing neocoronary pneumonia, an extract, a preparation method and an application thereof.
[ background of the invention ]
The new infectious diseases of the new coronary pneumonia outbreak in a plurality of countries all over the world, and practice proves that the traditional Chinese medicine highlights unique advantages in the major epidemic situation attack and solidness fighting, plays an irreplaceable role, complements and synergizes with the advantages of western medicine, and obtains good clinical effect.
Scientific support cannot be provided for scientific prevention and treatment, vast traditional Chinese medicine experts have an all-round way to develop scientific research and customs in epidemic situations, draw essences from ancient classic prescriptions by means of respective research characteristics, combine with a scheme of clinical diagnosis and treatment, rapidly provide a traditional Chinese medicine scheme, and play an important role in promoting scientific prevention and control and scientific treatment.
[ summary of the invention ]
The invention aims to provide a traditional Chinese medicine composition for preventing new coronary pneumonia, an extract, a preparation method and an application thereof.
The technical scheme of the invention is as follows: the invention provides a traditional Chinese medicine composition in a first aspect, which comprises the following components in parts by weight: 10-20 parts of honeysuckle, 10-20 parts of dandelion, 5-15 parts of houttuynia cordata, 5-15 parts of agastache rugosus, 5-15 parts of poria cocos, 5-15 parts of coix seeds, 4-8 parts of dried orange peel, 4-8 parts of mint, 4-8 parts of platycodon grandiflorum, 25-35 parts of fresh reed rhizome, 4-8 parts of ginger and 4-8 parts of Chinese dates.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of honeysuckle, 15 parts of dandelion, 10 parts of houttuynia cordata, 10 parts of agastache rugosus, 10 parts of poria cocos, 10 parts of coix seeds, 6 parts of dried orange peel, 6 parts of mint, 6 parts of platycodon grandiflorum, 30 parts of fresh reed rhizome, 6 parts of ginger and 6 parts of Chinese date.
In a second aspect, the present invention provides an extract of the above-mentioned Chinese medicinal composition.
Preferably, the extract is prepared according to the following preparation method:
crushing the raw materials of each component in the traditional Chinese medicine composition to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
centrifuging the extracting solution and collecting supernatant, carrying out ceramic membrane filtration on the supernatant and collecting ceramic membrane clear liquid;
performing membrane concentration on the ceramic membrane clear liquid to obtain a first concentrated solution;
carrying out vacuum concentration on the first concentrated solution to obtain a second concentrated solution;
and carrying out vacuum coagulation on the second concentrated solution to obtain the extract.
Preferably, the particle size of the extract is 0.1mm to 0.2 mm.
In a third aspect, the present invention provides a pharmaceutical preparation comprising the above extract as an active ingredient.
The fourth aspect of the invention provides a preparation method of an extract of a traditional Chinese medicine composition, which comprises the following steps:
a crushing step, in which raw materials of each component in the traditional Chinese medicine composition are crushed to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
an extraction process, namely adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
a microfiltration step, wherein the extracting solution is centrifuged and supernatant is collected, and the supernatant is subjected to ceramic membrane filtration and ceramic membrane supernatant is collected;
a membrane concentration step of performing membrane concentration on the ceramic membrane clear solution to obtain a first concentrated solution;
a vacuum concentration step of concentrating the first concentrated solution in vacuum to obtain a second concentrated solution;
and a solidification step of performing vacuum solidification on the second concentrated solution to obtain the extract.
Preferably, in the pulverizing step, the raw materials of dandelion, houttuynia cordata, agastache rugosus, poria cocos, mint, dried orange peel, platycodon grandiflorum and Chinese date are pulverized to obtain a pulverized material, and then the pulverized material is pulverized; cutting fresh rhizoma Phragmitis and rhizoma Zingiberis recens, and wet pulverizing; pulverizing Coicis semen and flos Lonicerae directly.
Preferably, in the extraction procedure, the extraction temperature is 25-30 ℃, the extraction rotation speed is 2000-15000 r/min, and the extraction time is 20-30 min;
and/or in the microfiltration working procedure, the microfiltration pressure is less than 0.28MPa, and the microfiltration temperature is less than or equal to 50 ℃;
and/or in the membrane concentration process, the membrane concentration pressure is less than 1.60Mpa, the membrane concentration temperature is less than or equal to 48 ℃, and the end point of the membrane concentration process is that the Baume value of the first concentrated solution is 0.5-1.5 or the membrane concentration time is more than 4 hours;
and/or in the vacuum concentration process, the vacuum concentration pressure is less than 1.60Mpa, the vacuum concentration temperature is less than or equal to 48 ℃, and the end point of the vacuum concentration process is that the Baume value of the second concentrated solution is 28-32;
and/or in the solidification process, the solidification pressure is less than-0.97 Mpa, and the solidification temperature is 35-45 ℃.
The fifth aspect of the invention provides an application of the traditional Chinese medicine composition, the extract or the pharmaceutical preparation in preparing a new coronary pneumonia prevention medicine.
The invention has the beneficial effects that: the traditional Chinese medicine composition and the extract thereof adopt components with homology of medicine and food, have more mild medicine property, and have better effects in the aspects of clearing heat, dispelling wind, clearing lung, detoxifying, expelling pathogenic factors, removing dirt, strengthening spleen, eliminating dampness, relieving cough, reducing phlegm and the like; according to the preparation method of the extract, the extract of the prepared traditional Chinese medicine composition is loose powder with a certain granularity through low-temperature extraction, low-temperature concentration and natural solidification, so that the active ingredients in the raw materials can be better reserved, and meanwhile, auxiliary materials are not required to be added for granulation.
[ description of the drawings ]
FIG. 1 is a graph showing the statistical results of the administration effect of the extracts of the Chinese medicinal composition in the application example of the present invention.
[ detailed description ] embodiments
The invention is further described with reference to the following figures and embodiments.
Infectious pneumonia belongs to the epidemic disease category in traditional Chinese medicine, the winter and spring seasons are the high-incidence seasons of epidemic diseases, the pathogeny often occurs when healthy qi of a human body is insufficient and the qi of ying and wei is not solid, and the pathogenic factors such as dampness, heat, wind, cold and the like invade the body while the body is still hot, and the pathogenic factors enter the interior to transform into heat.
The applicant conjectures that damp turbidity is accompanied with heat toxin according to the reported symptoms, and the accumulation of damp-heat is the main pathogenesis of the novel coronavirus pneumonia: the applicant considers that the treatment mainly comprises clearing heat, dispersing wind, clearing lung, detoxifying, expelling pathogenic factors, strengthening spleen, eliminating dampness, relieving cough and reducing sputum, and the like, because the heat blocks qi movement and the lung qi movement is dispersed, purified and descended, so that the symptoms of cough, chest distress, breath holding and the like are caused, and the symptoms of transportation and transformation disorder, dampness turbidity and internal stagnation, caused by the dampness invading spleen and stomach, fatigue, weakness, gastrointestinal discomfort and the like are caused.
[ composition formulation ]
The embodiment of the invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 10-20 parts of honeysuckle, 10-20 parts of dandelion, 5-15 parts of houttuynia cordata, 5-15 parts of agastache rugosus, 5-15 parts of poria cocos, 5-15 parts of coix seeds, 4-8 parts of dried orange peel, 4-8 parts of mint, 4-8 parts of platycodon grandiflorum, 25-35 parts of fresh reed rhizome, 4-8 parts of ginger and 4-8 parts of Chinese dates.
The traditional Chinese medicine composition has a reasonable formula, and honeysuckle flower has the effects of clearing away heat and toxic materials and cooling and dispersing wind heat according to the formula of the traditional medicine; the dandelion has the effects of clearing away heat and toxic materials, promoting urination and dissipating stagnation; the heartleaf houttuynia herb clears away heat and toxic materials, eliminates carbuncle and expels pus; fresh rhizoma Phragmitis has effects of clearing heat, promoting fluid production, purging pathogenic fire, and relieving restlessness; the four herbs are monarch drugs for clearing lung heat to remove toxicity and dispersing lung qi to clear and descend.
Poria has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; the coix seeds have the effects of tonifying spleen, promoting diuresis, clearing heat and expelling pus; pericarpium Citri Tangerinae has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and eliminating phlegm; the three medicines have the effects of eliminating dampness and strengthening spleen, and the platycodon root is matched to diffuse lung and eliminate phlegm, relieve sore throat and relieve cough, so that the platycodon root has the effects of clearing and resolving heat phlegm, and the four medicines are used as ministerial medicines.
The mint is pungent and cool and disperses, and can disperse wind and heat, clear and relieve headache and eyes; herba Agastaches is pungent in flavor and warm in property and can repel dirt, promote qi circulation and eliminate pathogenic factors, and harmonize the middle warmer and dispel dampness; the two herbs are both exterior-releasing herbs, but they are pungent but not drastic, warm and cool in combination, neither dry nor cold, and can enhance the action of promoting the circulation of exterior.
Ginger dispels cold to arrest cough, and jujube invigorates qi and nourishes blood, so the two herbs can harmonize the property of the medicine and improve the qi of ying and wei, and are also used as guiding herbs.
The combination of the medicines can clear heat toxin, eliminate dampness, promote the smooth lung qi and eliminate fever, cough, chest distress and breath holding.
In the traditional Chinese medicine composition, all the components are traditional Chinese medicines with homology of medicine and food, so that the medicine property is mild.
In an optional embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of honeysuckle, 15 parts of dandelion, 10 parts of houttuynia cordata, 10 parts of agastache rugosus, 10 parts of poria cocos, 10 parts of coix seeds, 6 parts of dried orange peel, 6 parts of mint, 6 parts of platycodon grandiflorum, 30 parts of fresh reed rhizome, 6 parts of ginger and 6 parts of Chinese date.
[ preparation of extract ]
The embodiment of the invention also provides a preparation method of the extract of the traditional Chinese medicine composition, which comprises the following steps:
a crushing step, in which raw materials of each component in the traditional Chinese medicine composition are crushed to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
an extraction process, namely adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
a microfiltration step, wherein the extracting solution is centrifuged and supernatant is collected, and the supernatant is subjected to ceramic membrane filtration and ceramic membrane supernatant is collected;
a membrane concentration step of performing membrane concentration on the ceramic membrane clear solution to obtain a first concentrated solution;
a vacuum concentration step of concentrating the first concentrated solution in vacuum to obtain a second concentrated solution;
and a solidification step of performing vacuum solidification on the second concentrated solution to obtain the extract.
In the pulverizing step, different pulverizing treatments can be performed according to the characteristics of the raw materials with different components, specifically, the raw materials of dandelion, houttuynia cordata, agastache rugosus, poria cocos, mint, dried orange peel and platycodon grandiflorum are pulverized to obtain a pulverized product, and then the pulverized product is pulverized; cutting fresh rhizoma Phragmitis, fructus Jujubae and rhizoma Zingiberis recens, and wet pulverizing; pulverizing Coicis semen and flos Lonicerae directly.
In the extraction process, the extraction temperature is 25-30 ℃, the extraction rotating speed (the rotating speed of an extractor) is 2000-15000 r/min, and the extraction time is 20-30 min. In the extraction step, the mass ratio of the raw material fine powder to water is 1 (15-25), preferably 1: 20. In this embodiment, the active ingredients in the raw material fine powder of the Chinese medicinal composition are extracted under the action of the pressure of the water flow rotating at a high speed at a normal temperature of 25 to 30 ℃.
In the microfiltration process, firstly, filter residues are removed through centrifugation, supernatant is collected and purified, the microfiltration pressure is less than 0.28MPa, the microfiltration temperature is less than or equal to 50 ℃, and in the microfiltration process, water is added, wherein the adding amount is 15% -20% of the water amount added in the extraction process.
In the membrane concentration process, the membrane concentration pressure is less than 1.60Mpa, the membrane concentration temperature is less than or equal to 48 ℃, and the end point of the membrane concentration process is that the Baume value of the first concentrated solution is 0.5-1.5 or the membrane concentration time is more than 4 hours. In the vacuum concentration process, the vacuum concentration pressure is less than 1.60Mpa, the vacuum concentration temperature is less than or equal to 48 ℃, and the end point of the vacuum concentration process is that the Baume value of the second concentrated solution is 28-32. In this example, the active ingredients in the raw materials were reduced by low-temperature concentration.
In the solidification process, the solidification pressure is less than-0.97 Mpa, and the solidification temperature is 35-45 ℃. In this embodiment, the second concentrated solution is naturally solidified, the extract of the prepared traditional Chinese medicine composition is in a loose powder form with a certain particle size, no other auxiliary materials are required to be added, no granulation is required, and the extract of the traditional Chinese medicine composition can be directly used as a solid beverage-like pharmaceutical preparation, which is completely different from the traditional Chinese medicine granule. Specifically, the particle size of the extract is 0.1 mm-0.2 mm.
According to the embodiment of the invention, the raw materials of the traditional Chinese medicine composition are sequentially extracted, microfiltered, concentrated by a membrane and concentrated in vacuum, no auxiliary material is added, and finally, the raw materials are naturally solidified into loose powder with certain granularity directly under the environment of negative pressure, low temperature and drying, so that the extract is obtained.
The extract prepared by the embodiment is in a loose powder shape with certain granularity, can be directly brewed by water, the soup color after brewing is clearer than that of the traditional Chinese medicine granule, and meanwhile, the amount of the extract required by brewing is less than that of the traditional Chinese medicine granule. That is to say, the extract prepared by the embodiment can be used as solid beverage for production, can meet large-scale and standardized production, can be rapidly put on the market, and meanwhile, the solid beverage is free of decoction, can be dissolved after being mixed with water, and is convenient and rapid.
Of course, it will be understood by those skilled in the art that the extract of the above-mentioned Chinese medicinal composition can be made into other oral dosage forms, such as capsule, tablet, oral liquid or syrup, besides being directly used as granule.
The traditional Chinese medicine composition, the extract of the traditional Chinese medicine composition and the pharmaceutical preparation containing the extract are suitable for preventing new coronary pneumonia, and are particularly suitable for preventing new coronary pneumonia in young adults.
Example 1
This embodiment 1 provides a method for preparing an extract of a traditional Chinese medicine composition, which specifically includes the following steps:
step 1, pretreatment: 1 ton of total material, and the following weight ratio: 11.6% of honeysuckle, 11.6% of dandelion, 7.7% of houttuynia cordata, 7.7% of wrinkled gianthyssop herb, 7.7% of poria cocos, 7.7% of coix seed, 4.6% of dried orange peel, 4.6% of mint, 4.6% of platycodon grandiflorum, 23% of fresh reed rhizome, 4.6% of ginger and 4.6% of Chinese date.
Crushing the raw materials of dandelion, houttuynia cordata, agastache rugosus, poria cocos, mint, dried orange peel, platycodon grandiflorum and Chinese date, drying the raw materials for 0.5-1 h at 75-80 ℃ by using a dryer if the water content of the raw materials is large, crushing the crushed raw materials, directly crushing coix seed and honeysuckle, cutting fresh reed rhizome and ginger by using a cutting machine, and then crushing by a wet method, wherein the crushed fine powder can pass through a 30-mesh screen.
Step 2, wall breaking extraction: the method comprises the steps of adopting a 500L extraction tank, putting raw materials into the extraction tank in batches of about 20kg each time, adding purified water according to the proportion of 1:20, enabling the temperature of feed liquid to be 25-30 ℃, uniformly stirring, and then conveying the feed liquid to an extraction wall breaking machine set (extractor) for extraction, wherein the extraction time is 20-30 min.
Step 3, centrifugation: centrifuging the extracting solution, wherein the frequency of a main centrifugal machine is 42.0Hz, the frequency of an auxiliary machine is 32.0Hz, the feeding frequency is 14.0Hz to 18.0Hz, and 5 percent to 10 percent of pure water is additionally added in the centrifuging process.
Step 4, microfiltration: and (3) filtering the centrifuged feed liquid by using a ceramic membrane, wherein the operating pressure is lower than 0.28MPa, the temperature is less than or equal to 50 ℃, and 15-20% of pure water is additionally added in the microfiltration process.
And step 5, membrane concentration: the microfiltration clear liquid is subjected to membrane concentration, the operation pressure is lower than 1.60MPa, and the temperature is less than or equal to 48 ℃. And when the membrane concentrated feed liquid reaches 0.5-1.5 Baume or the concentration cycle time of the feed liquid exceeds 4 hours, receiving the feed liquid.
Step 6, vacuum concentration: and (3) carrying out vacuum concentration on the membrane concentrated solution, wherein the concentration temperature is 35-45 ℃, and the vacuum degree is lower than-0.095 MPa. And collecting when the concentrated extract is 28-32 Baume.
Step 7, natural solidification: naturally solidifying the concentrated extract at 30-45 deg.C under vacuum degree lower than-0.097 MPa.
Application example
According to the application example, the effects of the extract prepared in the embodiment 1 of the invention on clearing heat, dispelling wind, clearing lung, detoxifying, expelling pathogenic factors, tonifying spleen, eliminating dampness, relieving cough, reducing sputum and the like are researched through group comparison investigation.
In this application example, 300 persons were randomly invited to the experiment, and 300 persons were divided into 3 groups of 100 persons on average. The first group provides one dose of the product twice a day for each person, and each dose is one gram of the product; a second group provides twice daily, two doses per person, one gram of the product per dose; the third group provides the product twice a day for each person, three doses each time, and one gram of the product; for four weeks, the effects of clearing heat, dispelling wind, clearing lung, removing toxic substances, expelling pathogenic factors, removing dirt, invigorating spleen, eliminating dampness, relieving cough and reducing sputum of all experimental participants were investigated once a week, and the investigation results are shown in fig. 1.
Referring to fig. 1, ninety percent of the persons participating in the experiment considered that the product has better effects in clearing heat and dispersing wind, clearing lung and detoxifying, expelling pathogenic factors and removing dirt, strengthening spleen and eliminating dampness, relieving cough and reducing sputum, and the like, wherein the second group has the highest satisfaction degree in four surveys, that is, each person provides twice a day, two doses each time, and the administration mode of one gram of the product is the most economical and the best effect.
While the foregoing is directed to embodiments of the present invention, it will be understood by those skilled in the art that various changes may be made without departing from the spirit and scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 10-20 parts of honeysuckle, 10-20 parts of dandelion, 5-15 parts of houttuynia cordata, 5-15 parts of agastache rugosus, 5-15 parts of poria cocos, 5-15 parts of coix seeds, 4-8 parts of dried orange peel, 4-8 parts of mint, 4-8 parts of platycodon grandiflorum, 25-35 parts of fresh reed rhizome, 4-8 parts of ginger and 4-8 parts of Chinese dates.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, in parts by weight: 15 parts of honeysuckle, 15 parts of dandelion, 10 parts of houttuynia cordata, 10 parts of agastache rugosus, 10 parts of poria cocos, 10 parts of coix seeds, 6 parts of dried orange peel, 6 parts of mint, 6 parts of platycodon grandiflorum, 30 parts of fresh reed rhizome, 6 parts of ginger and 6 parts of Chinese date.
3. An extract of the Chinese medicinal composition of claim 1 or 2.
4. The extract of the Chinese medicinal composition according to claim 3, which is prepared according to the following preparation method:
crushing the raw materials of each component in the traditional Chinese medicine composition to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
centrifuging the extracting solution and collecting supernatant, carrying out ceramic membrane filtration on the supernatant and collecting ceramic membrane clear liquid;
performing membrane concentration on the ceramic membrane clear liquid to obtain a first concentrated solution;
carrying out vacuum concentration on the first concentrated solution to obtain a second concentrated solution;
and carrying out vacuum coagulation on the second concentrated solution to obtain the extract.
5. The extract of the Chinese medicinal composition according to claim 4, wherein the particle size of the extract is 0.1mm to 0.2 mm.
6. A pharmaceutical preparation comprising the extract according to any one of claims 3 to 5 as an active ingredient.
7. A preparation method of an extract of a traditional Chinese medicine composition is characterized by comprising the following steps:
a crushing step, in which raw materials of each component in the traditional Chinese medicine composition are crushed to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
an extraction process, namely adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
a microfiltration step, wherein the extracting solution is centrifuged and supernatant is collected, and the supernatant is subjected to ceramic membrane filtration and ceramic membrane supernatant is collected;
a membrane concentration step of performing membrane concentration on the ceramic membrane clear solution to obtain a first concentrated solution;
a vacuum concentration step of concentrating the first concentrated solution in vacuum to obtain a second concentrated solution;
and a solidification step of performing vacuum solidification on the second concentrated solution to obtain the extract.
8. The method for preparing an extract of a chinese medicinal composition according to claim 7, wherein in the pulverizing step, the raw materials of dandelion, houttuynia cordata, agastache rugosus, poria cocos, mint, dried orange peel, platycodon grandiflorum, and jujube are pulverized to obtain a pulverized material, and the pulverized material is pulverized; cutting fresh rhizoma Phragmitis and rhizoma Zingiberis recens, and wet pulverizing; pulverizing Coicis semen and flos Lonicerae directly.
9. The method for preparing an extract of a Chinese medicinal composition according to claim 7, wherein in the extraction step, the extraction temperature is 25 to 30 ℃, the extraction rotation speed is 2000 to 15000r/min, and the extraction time is 20 to 30 min;
and/or in the microfiltration working procedure, the microfiltration pressure is less than 0.28MPa, and the microfiltration temperature is less than or equal to 50 ℃;
and/or in the membrane concentration process, the membrane concentration pressure is less than 1.60Mpa, the membrane concentration temperature is less than or equal to 48 ℃, and the end point of the membrane concentration process is that the Baume value of the first concentrated solution is 0.5-1.5 or the membrane concentration time is more than 4 hours;
and/or in the vacuum concentration process, the vacuum concentration pressure is less than 1.60Mpa, the vacuum concentration temperature is less than or equal to 48 ℃, and the end point of the vacuum concentration process is that the Baume value of the second concentrated solution is 28-32;
and/or in the solidification process, the solidification pressure is less than-0.97 Mpa, and the solidification temperature is 35-45 ℃.
10. Use of the Chinese medicinal composition of claim 1 or 2 or the extract of any one of claims 3 to 5 or the pharmaceutical preparation of claim 6 in the preparation of a medicament for preventing neocoronary pneumonia.
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| Title |
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| 冯怡: "《中药固体制剂技术理论与实践》", 31 March 2017, 中国中医药出版社 * |
| 分子态: "冠状病毒肺炎中药预防方 推荐冠状肺炎药方", 《网络公开》 * |
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Application publication date: 20210105 |