CN112168932A - Traditional Chinese medicine composition and extract for preventing new coronary pneumonia, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition and extract for preventing new coronary pneumonia, and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing neocoronary pneumonia, an extract, a preparation method and an application thereof. The traditional Chinese medicine composition comprises: 5-15 parts of fresh reed rhizome, 4-8 parts of honeysuckle, 4-8 parts of mulberry leaf, 1-5 parts of dried orange peel, 1-5 parts of coix seed and 1-5 parts of wrinkled gianthyssop herb. The traditional Chinese medicine composition and the extract thereof adopt components with homology of medicine and food, have more mild medicine property, and have better effects on the aspects of clearing away heat and toxic materials, promoting the production of body fluid, purging pathogenic fire, invigorating spleen, eliminating dampness and the like; according to the preparation method, through low-temperature extraction, low-temperature concentration and natural solidification, the extract of the prepared traditional Chinese medicine composition is loose powder with a certain granularity, so that the effective ingredients in the raw materials can be better reserved, and auxiliary materials are not required to be added for granulation.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing neocoronary pneumonia, an extract, a preparation method and an application thereof.
[ background of the invention ]
The new infectious diseases of the new coronary pneumonia outbreak in a plurality of countries all over the world, and practice proves that the traditional Chinese medicine highlights unique advantages in the major epidemic situation attack and solidness fighting, plays an irreplaceable role, complements and synergizes with the advantages of western medicine, and obtains good clinical effect.
Scientific support cannot be provided for scientific prevention and treatment, vast traditional Chinese medicine experts have an all-round way to develop scientific research and customs in epidemic situations, draw essences from ancient classic prescriptions by means of respective research characteristics, combine with a scheme of clinical diagnosis and treatment, rapidly provide a traditional Chinese medicine scheme, and play an important role in promoting scientific prevention and control and scientific treatment.
[ summary of the invention ]
The invention aims to provide a traditional Chinese medicine composition for preventing new coronary pneumonia, an extract, a preparation method and an application thereof.
The technical scheme of the invention is as follows: the invention provides a traditional Chinese medicine composition in a first aspect, which comprises the following components in parts by weight: 5-15 parts of fresh reed rhizome, 4-8 parts of honeysuckle, 4-8 parts of mulberry leaf, 1-5 parts of dried orange peel, 1-5 parts of coix seed and 1-5 parts of wrinkled gianthyssop herb.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of fresh reed rhizome, 6 parts of honeysuckle, 6 parts of mulberry leaf, 3 parts of dried orange peel, 3 parts of coix seed and 3 parts of wrinkled gianthyssop herb.
In a second aspect, the present invention provides an extract of the above-mentioned Chinese medicinal composition.
Preferably, the extract is prepared according to the following preparation method:
crushing the raw materials of each component in the traditional Chinese medicine composition to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
centrifuging the extracting solution and collecting supernatant, carrying out ceramic membrane filtration on the supernatant and collecting ceramic membrane clear liquid;
performing membrane concentration on the ceramic membrane clear liquid to obtain a first concentrated solution;
carrying out vacuum concentration on the first concentrated solution to obtain a second concentrated solution;
and carrying out vacuum coagulation on the second concentrated solution to obtain the extract.
Preferably, the particle size of the extract is 0.1mm to 0.2 mm.
In a third aspect, the present invention provides a pharmaceutical preparation comprising the above extract as an active ingredient.
The fourth aspect of the invention provides a preparation method of an extract of a traditional Chinese medicine composition, which comprises the following steps:
a crushing step, in which raw materials of each component in the traditional Chinese medicine composition are crushed to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
an extraction process, namely adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
a microfiltration step, wherein the extracting solution is centrifuged and supernatant is collected, and the supernatant is subjected to ceramic membrane filtration and ceramic membrane supernatant is collected;
a membrane concentration step of performing membrane concentration on the ceramic membrane clear solution to obtain a first concentrated solution;
a vacuum concentration step of concentrating the first concentrated solution in vacuum to obtain a second concentrated solution;
and a solidification step of performing vacuum solidification on the second concentrated solution to obtain the extract.
Preferably, in the crushing step, the raw materials of mulberry leaves, ageratum and dried orange peels are crushed to obtain crushed materials, and then the crushed materials are crushed; cutting fresh rhizoma Phragmitis, and wet pulverizing; pulverizing Coicis semen and flos Lonicerae directly.
Preferably, in the extraction procedure, the extraction temperature is 25-30 ℃, the extraction rotation speed is 2000-15000 r/min, and the extraction time is 20-30 min;
and/or in the microfiltration working procedure, the microfiltration pressure is less than 0.28MPa, and the microfiltration temperature is less than or equal to 50 ℃;
and/or in the membrane concentration process, the membrane concentration pressure is less than 1.60Mpa, the membrane concentration temperature is less than or equal to 48 ℃, and the end point of the membrane concentration process is that the Baume value of the first concentrated solution is 0.5-1.5 or the membrane concentration time is more than 4 hours;
and/or in the vacuum concentration process, the vacuum concentration pressure is less than 1.60Mpa, the vacuum concentration temperature is less than or equal to 48 ℃, and the end point of the vacuum concentration process is that the Baume value of the second concentrated solution is 28-32;
and/or in the solidification process, the solidification pressure is less than-0.97 Mpa, and the solidification temperature is 35-45 ℃.
The fifth aspect of the invention provides an application of the traditional Chinese medicine composition, the extract or the pharmaceutical preparation in preparing a new coronary pneumonia prevention medicine.
The invention has the beneficial effects that: the traditional Chinese medicine composition and the extract thereof adopt components with homology of medicine and food, have more mild medicine property, and have better effects on the aspects of clearing away heat and toxic materials, promoting the production of body fluid, purging pathogenic fire, invigorating spleen, eliminating dampness and the like; according to the preparation method of the extract, the extract of the prepared traditional Chinese medicine composition is loose powder with a certain granularity through low-temperature extraction, low-temperature concentration and natural solidification, so that the active ingredients in the raw materials can be better reserved, and meanwhile, auxiliary materials are not required to be added for granulation.
[ detailed description ] embodiments
The present invention will be further described with reference to the following embodiments.
Infectious pneumonia belongs to the epidemic disease category in traditional Chinese medicine, the winter and spring seasons are the high-incidence seasons of epidemic diseases, the pathogeny often occurs when healthy qi of a human body is insufficient and the qi of ying and wei is not solid, and the pathogenic factors such as dampness, heat, wind, cold and the like invade the body while the body is still hot, and the pathogenic factors enter the interior to transform into heat.
The applicant conjectures that the disease belongs to the category of epidemic diseases in traditional Chinese medicine according to the reported symptoms, the core pathogenesis of the disease is 'dampness, toxicity, blood stasis and block', the disease is positioned in the lung and the spleen, the collateral can be injured, blood can enter, and the new coronary pneumonia can be effectively prevented by clearing away the dampness, heat and toxic stasis of related meridians.
[ composition formulation ]
The embodiment of the invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 5-15 parts of fresh reed rhizome, 4-8 parts of honeysuckle, 4-8 parts of mulberry leaf, 1-5 parts of dried orange peel, 1-5 parts of coix seed and 1-5 parts of wrinkled gianthyssop herb.
The traditional Chinese medicine composition disclosed by the invention is reasonable in prescription, and the fresh reed rhizome is a monarch drug which has the effects of clearing heat, promoting the secretion of saliva or body fluid, promoting urination and purging fire and enters the lung and stomach channels according to the prescription of the traditional medicine; honeysuckle flower has the effects of clearing heat and removing toxicity, cooling and dispersing wind heat, and can enter lung, heart and stomach channels, and mulberry leaf is matched with the functions of clearing lung and moistening dryness, clearing liver and improving eyesight, and can enter lung and liver channels, and is used as a ministerial drug; the dried orange peel has the functions of regulating qi, stimulating appetite, eliminating dampness and phlegm, entering lung and spleen channels, and is matched with the coix seed for strengthening spleen, promoting diuresis, clearing heat and stopping diarrhea, and entering spleen, stomach and lung channels, which are used as adjuvant drugs; agastache rugosus is a guiding drug for promoting the circulation of qi and regulating the middle warmer, removing dirt and dampness and entering spleen, stomach and lung channels; the combination of the medicines has the effects of clearing away heat and toxic materials, promoting the production of body fluid, purging pathogenic fire, invigorating spleen and eliminating dampness.
In the traditional Chinese medicine composition, all the components are traditional Chinese medicines with homology of medicine and food, so that the medicine property is mild.
In an optional embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of fresh reed rhizome, 6 parts of honeysuckle, 6 parts of mulberry leaf, 3 parts of dried orange peel, 3 parts of coix seed and 3 parts of wrinkled gianthyssop herb.
[ preparation of extract ]
The embodiment of the invention also provides a preparation method of the extract of the traditional Chinese medicine composition, which comprises the following steps:
a crushing step, in which raw materials of each component in the traditional Chinese medicine composition are crushed to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
an extraction process, namely adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
a microfiltration step, wherein the extracting solution is centrifuged and supernatant is collected, and the supernatant is subjected to ceramic membrane filtration and ceramic membrane supernatant is collected;
a membrane concentration step of performing membrane concentration on the ceramic membrane clear solution to obtain a first concentrated solution;
a vacuum concentration step of concentrating the first concentrated solution in vacuum to obtain a second concentrated solution;
and a solidification step of performing vacuum solidification on the second concentrated solution to obtain the extract.
In the crushing process, different crushing treatments can be carried out according to the characteristics of raw materials with different components, specifically, raw materials of mulberry leaves, ageratum and dried orange peels are crushed to obtain crushed materials, and then the crushed materials are crushed; cutting fresh rhizoma Phragmitis, and wet pulverizing; pulverizing Coicis semen and flos Lonicerae directly.
In the extraction process, the extraction temperature is 25-30 ℃, the extraction rotating speed (the rotating speed of an extractor) is 2000-15000 r/min, and the extraction time is 20-30 min. In the extraction step, the mass ratio of the raw material fine powder to water is 1 (15-25), preferably 1: 20. In this embodiment, the active ingredients in the raw material fine powder of the Chinese medicinal composition are extracted under the action of the pressure of the water flow rotating at a high speed at a normal temperature of 25 to 30 ℃.
In the microfiltration process, firstly, filter residues are removed through centrifugation, supernatant is collected and purified, the microfiltration pressure is less than 0.28MPa, the microfiltration temperature is less than or equal to 50 ℃, and in the microfiltration process, water is added, wherein the adding amount is 15% -20% of the water amount added in the extraction process.
In the membrane concentration process, the membrane concentration pressure is less than 1.60Mpa, the membrane concentration temperature is less than or equal to 48 ℃, and the end point of the membrane concentration process is that the Baume value of the first concentrated solution is 0.5-1.5 or the membrane concentration time is more than 4 hours. In the vacuum concentration process, the vacuum concentration pressure is less than 1.60Mpa, the vacuum concentration temperature is less than or equal to 48 ℃, and the end point of the vacuum concentration process is that the Baume value of the second concentrated solution is 28-32. In this example, the active ingredients in the raw materials were reduced by low-temperature concentration.
In the solidification process, the solidification pressure is less than-0.97 Mpa, and the solidification temperature is 35-45 ℃. In this embodiment, the second concentrated solution is naturally solidified, the extract of the prepared traditional Chinese medicine composition is in a loose powder form with a certain particle size, no other auxiliary materials are required to be added, no granulation is required, and the extract of the traditional Chinese medicine composition can be directly used as a solid beverage-like pharmaceutical preparation, which is completely different from the traditional Chinese medicine granule. Specifically, the particle size of the extract is 0.1 mm-0.2 mm.
According to the embodiment of the invention, the raw materials of the traditional Chinese medicine composition are sequentially extracted, microfiltered, concentrated by a membrane and concentrated in vacuum, no auxiliary material is added, and finally, the raw materials are naturally solidified into loose powder with certain granularity directly under the environment of negative pressure, low temperature and drying, so that the extract is obtained.
The extract prepared by the embodiment is in a loose powder shape with certain granularity, can be directly brewed by water, the soup color after brewing is clearer than that of the traditional Chinese medicine granule, and meanwhile, the amount of the extract required by brewing is less than that of the traditional Chinese medicine granule. That is to say, the extract prepared by the embodiment can be used as solid beverage for production, can meet large-scale and standardized production, can be rapidly put on the market, and meanwhile, the solid beverage is free of decoction, can be dissolved after being mixed with water, and is convenient and rapid.
Of course, it will be understood by those skilled in the art that the extract of the above-mentioned Chinese medicinal composition can be made into other oral dosage forms, such as capsule, tablet, oral liquid or syrup, besides being directly used as granule.
The traditional Chinese medicine composition, the extract of the traditional Chinese medicine composition and the pharmaceutical preparation containing the extract are suitable for preventing new coronary pneumonia, and are particularly suitable for preventing new coronary pneumonia of children.
Example 1
This embodiment 1 provides a method for preparing an extract of a traditional Chinese medicine composition, which specifically includes the following steps:
step 1, pretreatment: 1 ton of total material, and the following weight ratio: 12 parts of fresh reed rhizome, 6 parts of honeysuckle, 6 parts of mulberry leaf, 3 parts of dried orange peel, 3 parts of coix seed and 3 parts of wrinkled gianthyssop herb, and the raw materials are crushed and fully mixed.
Crushing the mulberry leaves, the agastache rugosus and the dried orange peel, drying the raw materials for 0.5-1 h at 75-80 ℃ by using a dryer if the water content of the raw materials is large, crushing the crushed raw materials, directly crushing the coix seeds and the honeysuckle, crushing the fresh reed rhizome by using a chopper and then carrying out wet crushing, and sieving the crushed fine powder by using a 30-mesh sieve.
Step 2, wall breaking extraction: the method comprises the steps of adopting a 500L extraction tank, putting raw materials into the extraction tank in batches of about 20kg each time, adding purified water according to the proportion of 1:20, enabling the temperature of feed liquid to be 25-30 ℃, uniformly stirring, and then conveying the feed liquid to an extraction wall breaking machine set (extractor) for extraction, wherein the extraction time is 20-30 min.
Step 3, centrifugation: centrifuging the extracting solution, wherein the frequency of a main centrifugal machine is 42.0Hz, the frequency of an auxiliary machine is 32.0Hz, the feeding frequency is 14.0Hz to 18.0Hz, and 5 percent to 10 percent of pure water is additionally added in the centrifuging process.
Step 4, microfiltration: and (3) filtering the centrifuged feed liquid by using a ceramic membrane, wherein the operating pressure is lower than 0.28MPa, the temperature is less than or equal to 50 ℃, and 15-20% of pure water is additionally added in the microfiltration process.
And step 5, membrane concentration: the microfiltration clear liquid is subjected to membrane concentration, the operation pressure is lower than 1.60MPa, and the temperature is less than or equal to 48 ℃. And when the membrane concentrated feed liquid reaches 0.5-1.5 Baume or the concentration cycle time of the feed liquid exceeds 4 hours, receiving the feed liquid.
Step 6, vacuum concentration: and (3) carrying out vacuum concentration on the membrane concentrated solution, wherein the concentration temperature is 35-45 ℃, and the vacuum degree is lower than-0.095 MPa. And collecting when the concentrated extract is 28-32 Baume.
Step 7, natural solidification: naturally solidifying the concentrated extract at 30-45 deg.C under vacuum degree lower than-0.097 MPa.
Application example
In the application example, the effects of the extract prepared in the embodiment 1 of the invention on clearing away heat and toxic materials, promoting the production of body fluid, purging pathogenic fire, invigorating spleen, eliminating dampness and the like are researched through group comparison investigation.
In the application example, the first group of participants is a group of children aged 1-3 years, 0.6g of the product (the extract obtained in example 1) can be taken each time, the product can be taken with 50-100 mL of warm water, 1 time a day, one conditioning or preventing period is taken for one week continuously, and four periods are taken; the second group of participants is 4-12 years old children, each time 0.6g of the product (the extract obtained in example 1) is taken, the product can be taken with 50-100 mL of warm water, 2 times a day, one conditioning or preventing period is continuously taken for one week, and the four periods are taken; the third group of participants is children and adults over 13 years old, and 2g of the product (extract obtained in example 1) is taken each time, and the product can be taken with 100-200 mL of warm water 2 times a day, and is taken for four periods, wherein one period of conditioning or preventing is continuously taken for one week.
Among the people participating in the experiment, ninety percent of the three groups think that the product has better effects on clearing away heat and toxic materials, promoting the production of body fluid and purging intense heat after being taken for one to two cycles, and has better effects on clearing damp and heat after being taken for four cycles.
While the foregoing is directed to embodiments of the present invention, it will be understood by those skilled in the art that various changes may be made without departing from the spirit and scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 5-15 parts of fresh reed rhizome, 4-8 parts of honeysuckle, 4-8 parts of mulberry leaf, 1-5 parts of dried orange peel, 1-5 parts of coix seed and 1-5 parts of wrinkled gianthyssop herb.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, in parts by weight: 12 parts of fresh reed rhizome, 6 parts of honeysuckle, 6 parts of mulberry leaf, 3 parts of dried orange peel, 3 parts of coix seed and 3 parts of wrinkled gianthyssop herb.
3. An extract of the Chinese medicinal composition of claim 1 or 2.
4. The extract of the Chinese medicinal composition according to claim 3, which is prepared according to the following preparation method:
crushing the raw materials of each component in the traditional Chinese medicine composition to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
centrifuging the extracting solution and collecting supernatant, carrying out ceramic membrane filtration on the supernatant and collecting ceramic membrane clear liquid;
performing membrane concentration on the ceramic membrane clear liquid to obtain a first concentrated solution;
carrying out vacuum concentration on the first concentrated solution to obtain a second concentrated solution;
and carrying out vacuum coagulation on the second concentrated solution to obtain the extract.
5. The extract of the Chinese medicinal composition according to claim 4, wherein the particle size of the extract is 0.1mm to 0.2 mm.
6. A pharmaceutical preparation comprising the extract according to any one of claims 3 to 5 as an active ingredient.
7. A preparation method of an extract of a traditional Chinese medicine composition is characterized by comprising the following steps:
a crushing step, in which raw materials of each component in the traditional Chinese medicine composition are crushed to obtain raw material fine powder with the particle size of less than or equal to 30 meshes;
an extraction process, namely adding the raw material fine powder into water, stirring to form a material liquid, and conveying the material liquid to an extraction unit for extraction to obtain an extracting solution;
a microfiltration step, wherein the extracting solution is centrifuged and supernatant is collected, and the supernatant is subjected to ceramic membrane filtration and ceramic membrane supernatant is collected;
a membrane concentration step of performing membrane concentration on the ceramic membrane clear solution to obtain a first concentrated solution;
a vacuum concentration step of concentrating the first concentrated solution in vacuum to obtain a second concentrated solution;
and a solidification step of performing vacuum solidification on the second concentrated solution to obtain the extract.
8. The method for preparing an extract of a chinese medicinal composition according to claim 7, wherein in the pulverizing step, the raw materials of mulberry leaf, wrinkled giant hyssop and dried orange peel are pulverized to obtain a pulverized material, and then the pulverized material is pulverized; cutting fresh rhizoma Phragmitis, and wet pulverizing; pulverizing Coicis semen and flos Lonicerae directly.
9. The method for preparing an extract of a Chinese medicinal composition according to claim 7, wherein in the extraction step, the extraction temperature is 25 to 30 ℃, the extraction rotation speed is 2000 to 15000r/min, and the extraction time is 20 to 30 min;
and/or in the microfiltration working procedure, the microfiltration pressure is less than 0.28MPa, and the microfiltration temperature is less than or equal to 50 ℃;
and/or in the membrane concentration process, the membrane concentration pressure is less than 1.60Mpa, the membrane concentration temperature is less than or equal to 48 ℃, and the end point of the membrane concentration process is that the Baume value of the first concentrated solution is 0.5-1.5 or the membrane concentration time is more than 4 hours;
and/or in the vacuum concentration process, the vacuum concentration pressure is less than 1.60Mpa, the vacuum concentration temperature is less than or equal to 48 ℃, and the end point of the vacuum concentration process is that the Baume value of the second concentrated solution is 28-32;
and/or in the solidification process, the solidification pressure is less than-0.97 Mpa, and the solidification temperature is 35-45 ℃.
10. Use of the Chinese medicinal composition of claim 1 or 2 or the extract of any one of claims 3 to 5 or the pharmaceutical preparation of claim 6 in the preparation of a medicament for preventing neocoronary pneumonia.
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| CN113082170A (en) * | 2021-04-16 | 2021-07-09 | 黄冈师范学院 | Traditional Chinese medicine preparation for inhibiting 2019-nCoV and preparation method thereof |
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| CN113082170A (en) * | 2021-04-16 | 2021-07-09 | 黄冈师范学院 | Traditional Chinese medicine preparation for inhibiting 2019-nCoV and preparation method thereof |
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