CN117257863A - Trollium drop pill and preparation process thereof - Google Patents
Trollium drop pill and preparation process thereof Download PDFInfo
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- CN117257863A CN117257863A CN202311508095.3A CN202311508095A CN117257863A CN 117257863 A CN117257863 A CN 117257863A CN 202311508095 A CN202311508095 A CN 202311508095A CN 117257863 A CN117257863 A CN 117257863A
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- polyethylene glycol
- menthol
- stevioside
- chinese patent
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- 239000006187 pill Substances 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000003814 drug Substances 0.000 claims abstract description 27
- 241001312894 Trollius chinensis Species 0.000 claims abstract description 25
- 241000612118 Samolus valerandi Species 0.000 claims abstract description 18
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 17
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 17
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 17
- 229940041616 menthol Drugs 0.000 claims abstract description 17
- 229940013618 stevioside Drugs 0.000 claims abstract description 17
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000019202 steviosides Nutrition 0.000 claims abstract description 17
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims abstract description 14
- 206010057190 Respiratory tract infections Diseases 0.000 claims abstract description 4
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 201000007100 Pharyngitis Diseases 0.000 claims abstract description 3
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 3
- 206010044008 tonsillitis Diseases 0.000 claims abstract description 3
- 210000004072 lung Anatomy 0.000 claims abstract 2
- 239000000284 extract Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 241000628997 Flos Species 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000011229 interlayer Substances 0.000 claims description 2
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- -1 micropills Substances 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 239000007919 dispersible tablet Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 241000700605 Viruses Species 0.000 description 5
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 206010047482 Viral upper respiratory tract infection Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011020 pilot scale process Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 206010049590 Upper respiratory tract inflammation Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 208000011479 upper respiratory tract disease Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Chinese patent medicine for clearing heat and detoxicating. The Chinese patent medicine is prepared from the following raw materials in parts by mass: 500 parts of trollius chinensis bunge, 205.5 parts of polyethylene glycol 4000, 3 parts of stevioside and 1.5 parts of menthol, and 1000 parts of the trollius chinensis bunge is prepared. The traditional Chinese medicine provided by the invention is used for treating symptoms of upper respiratory tract infection, pharyngitis and tonsillitis caused by pathogenic wind-heat evil attacking the lung and excessive heat evil.
Description
Technical Field
The application relates to the technical field of medicines, in particular to a trollflower dripping pill and a preparation process thereof.
Background
Viral upper respiratory tract infection refers to upper respiratory tract inflammation caused by viruses, and has local symptoms such as systemic symptoms, rhinitis, pharyngitis, tonsillitis and the like with different degrees. Including common cold, influenza, adenovirus diseases, syncytial virus diseases, etc., are among the most common diseases of human beings, and the symptoms thereof can be light or heavy. At present, western medicine does not have specific medicines, and the treatment only mainly supports symptomatic treatment. Because of the wide variety of viruses, the infection range is wide, the immunity is not durable, and the virus can be maintained by means of repeated infection, so that the vaccine is widely used for preventing the virus. The traditional Chinese medicine has certain advantages compared with western medicine in treating the diseases. The diseases belong to the category of exogenous diseases in traditional Chinese medicine, and the symptoms of the diseases are seen in wind-warm disease, spring-warm disease, summer-heat-warm disease and the like, and in solar disease, shaoyang disease and yangming disease in typhoid fever. The report on the treatment of influenza by traditional Chinese medicine is more in the last fifties to the eighties, and clinical and laboratory researches on the treatment of viral upper respiratory tract infection by using a compound are continuously visible in the last 10 years. From the aspects of pathogenic characteristics and research trends, traditional Chinese medicine has a relatively development prospect for treating the diseases.
The use of antibiotics can shorten the upper respiratory tract disease course and relieve the upper respiratory tract infection symptoms, but usually has a certain side effect on human bodies and is easy to generate drug resistance. The Chinese medicinal injection may have acute toxic reaction and anaphylaxis in use. Thus, there remains a need in the art for a medicament that is easy to store and carry, has few side effects, and is stable for use in the treatment of upper respiratory tract infections.
Disclosure of Invention
In order to solve the technical problems, the invention provides a dripping pill prepared from pure Chinese herbal medicines, and the dripping pill has good curative effect and is convenient to take.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a Chinese patent medicine for clearing heat and detoxicating is mainly prepared from traditional Chinese medicine raw materials and auxiliary materials; 200-600 parts of trollius chinensis, 4000 100-300 parts of polyethylene glycol, 2-5 parts of stevioside and 1-3 parts of menthol.
Preferably, 300-500 parts of trollius chinensis, 4000 150-220 parts of polyethylene glycol, 2-4 parts of stevioside and 1-2 parts of menthol.
More preferably, 500 parts of trollius chinensis, 205.5 parts of polyethylene glycol 4000, 3 parts of stevioside and 1.5 parts of menthol.
The invention also aims at providing a preparation method of the Chinese patent medicine, which is characterized in that trollius chinensis bunge is weighed, added with water with the mass of 6-10 times that of the trollius chinensis bunge for 0.5-2 hours, extracted for 2-3 times under reflux, extracted for 1-2 hours each time, filtered after each extraction is finished, collected and combined with filtrate, recycled water, and the filtrate is concentrated to the density of 1.1-1.3 under reduced pressure and dried under reduced pressure at the temperature of 60-80 ℃ to obtain trollius chinensis bunge extract; the trollius chinensis bunge extract is mixed with stevioside, menthol and polyethylene glycol 4000, and is melted uniformly, and then is cooled by dripping to form a dripping pill preparation.
The preparation method is characterized by accurately weighing polyethylene glycol 4000 with a command amount, trollius chinensis extract, stevioside and menthol, firstly adding about 1/2 of the polyethylene glycol 4000 with the command amount into a clean and dry batching tank, setting the temperature of the hot water tank to be 76 ℃, heating the mixture through an interlayer to enable the mixture to be completely melted, then mixing the rest polyethylene glycol 4000 with the trollius chinensis extract with the command amount, adding the mixture into the completely melted polyethylene glycol 4000, finally adding the stevioside and the menthol in sequence, and after the materials are completely melted and the temperature reaches 76+/-6 ℃, preserving heat and stirring the mixture for about 30min to enable the materials to be uniformly mixed. The dripping temperature is controlled within 76+/-6 ℃.
Another object of the present invention is to provide a method for preparing trollius chinensis bunge extract, characterized in that: soaking weighed flos Trollii in 6-10 times of water for 0.5-2 hr, reflux extracting for 2-3 times, extracting for 1-2 hr each time, filtering after each extraction, collecting combined filtrate, recovering water, concentrating the filtrate under reduced pressure to density of 1.1-1.3, and drying under reduced pressure at 60-80deg.C.
The preparation method of the trollius chinensis bunge extract is characterized by comprising the steps of decocting weighed trollius chinensis bunge with water with the mass of 6-10 times for 2-3 times, decocting for 40-60 minutes each time, mixing decoctions, filtering, and concentrating filtrate under reduced pressure until the density is 1.1-1.3; drying under reduced pressure at 60-80deg.C. The trollius chinensis bunge extract is obtained.
Detailed Description
EXAMPLE 1 drop temperature study
Taking 500g of trollius chinensis bunge, decocting twice, adding 10 times of water for soaking for 1 hour for the first time, decocting for 1 hour for the second time, adding 10 times of water for decocting for 1 hour, decocting and filtering, combining filtrate, concentrating under reduced pressure to obtain clear paste with the relative density of 1.15-1.20 (70 ℃), drying under reduced pressure below 70 ℃, crushing, sieving with a fifth sieve, uniformly mixing extract powder with 4000205.5g of polyethylene glycol, 3g of stevioside and 1.5g of menthol, melting at 90+/-5 ℃ and then dripping into 1000 granules to obtain the Chinese medicinal composition.
The results show that: under the condition of the parameter, the weight difference of the dripping pills is larger, and the final production yield is lower. The phenomenon that the dripping pills which are dropped out of the individual dripping holes are obviously smaller can occur, the longer the dripping time is, the more abnormal dripping holes are, and the weight of the pills can be recovered to be normal after the dripping holes are dredged.
EXAMPLE 2 drop temperature study
Taking 500g of trollius chinensis bunge, decocting twice, adding 10 times of water for soaking for 1 hour for the first time, decocting for 1 hour for the second time, adding 10 times of water for decocting for 1 hour, decocting and filtering, combining filtrate, concentrating under reduced pressure to obtain clear paste with the relative density of 1.15-1.20 (70 ℃), drying under reduced pressure below 70 ℃, crushing, sieving with a fifth sieve, uniformly mixing extract powder with 4000205.5g of polyethylene glycol, 3g of stevioside and 1.5g of menthol, melting at 76+/-6 ℃ and then dripping into 1000 granules to obtain the Chinese medicinal composition.
The results show that: the temperature of the liquid medicine is controlled within the range of 70-82 ℃, the weight difference of the dripping pills is improved, and the abnormal phenomenon basically does not occur
Example 3 pilot scale validation
75kg of trollius chinensis bunge is taken and decocted twice, 10 times of water is added for soaking for 1 hour in the first time, water is added for 1 hour in the second time, decoction is decocted for 1 hour, decoction liquid is filtered, filtrate is combined, reduced pressure concentration is carried out to obtain clear paste with the relative density of 1.15-1.20 (70 ℃), drying is carried out under the reduced pressure below 70 ℃, crushing is carried out, no. five sieves are adopted, extract powder is evenly mixed with 30.82kg of polyethylene glycol 4000, 0.45kg of stevioside and 0.22kg of menthol, and dripping is carried out after melting at 76+/-6 ℃.
The results are shown in Table 1.
Table 1: pilot scale validation test results
Example 4 batch production
150kg of trollius chinensis bunge is taken and decocted twice, 10 times of water is added for soaking for 1 hour in the first time, water is added for 1 hour in the second time, decoction is decocted for 1 hour, decoction liquid is filtered, filtrate is combined, reduced pressure concentration is carried out to obtain clear paste with the relative density of 1.15-1.20 (70 ℃), drying is carried out under the reduced pressure below 70 ℃, crushing is carried out, no. five sieves are adopted, extract powder is evenly mixed with 4000.65 kg of polyethylene glycol, 0.9kg of stevioside and 0.45kg of menthol, and dripping is carried out after melting at 76+/-6 ℃.
The results are shown in Table 2.
Table 2: mass production test results
Table 3: pill weight difference experimental data
Claims (8)
1. A Chinese patent medicine for clearing heat and detoxicating is characterized in that: the Chinese patent medicine is mainly prepared from traditional Chinese medicine raw materials and auxiliary materials; the traditional Chinese medicine comprises the following raw materials in parts by weight: 200-600 parts of trollius chinensis bunge; the auxiliary materials are as follows: 4000 100-300 parts of polyethylene glycol, 2-5 parts of stevioside and 1-3 parts of menthol.
2. The Chinese patent medicine according to claim 1, wherein: 300-500 parts of trollius chinensis bunge, 4000 150-220 parts of polyethylene glycol, 2-4 parts of stevioside and 1-2 parts of menthol.
3. The Chinese patent medicine according to claim 2, wherein: 500 parts of trollius chinensis bunge, 205.5 parts of polyethylene glycol 4000, 3 parts of stevioside and 1.5 parts of menthol.
4. The method for preparing the Chinese patent medicine according to any one of claims 1 to 3, characterized in that: weighing flos Trollii, soaking in 6-10 times of water for 0.5-2 hr, decocting for 40-60 min each time, reflux extracting for 2-3 times, extracting for 1-2 hr each time, filtering after each extraction, collecting combined filtrates, recovering water, concentrating the filtrate under reduced pressure to density of 1.1-1.3, and drying under reduced pressure at 60-80deg.C to obtain flos Trollii extract; the trollius chinensis bunge extract is mixed with stevioside, menthol and polyethylene glycol 4000, and is melted uniformly, and then is cooled by dripping to form a dripping pill preparation.
5. The method for preparing the Chinese patent medicine according to claim 4, wherein the method comprises the following steps: accurately weighing polyethylene glycol 4000, trollius chinensis extract, stevioside and menthol, firstly adding about 1/2 of polyethylene glycol 4000 in the instruction amount into a clean and dry batching tank, setting the temperature of the hot water tank to be 76 ℃, heating the mixture through an interlayer to enable the mixture to be completely melted, then mixing the rest polyethylene glycol 4000 with trollius chinensis extract in the instruction amount, adding the mixture into the completely melted polyethylene glycol 4000, finally adding stevioside and menthol in sequence, and after the materials are completely melted and the temperature reaches 76+/-6 ℃, preserving heat and stirring for about 30min to enable the materials to be uniformly mixed. The dripping temperature is controlled within 76+/-6 ℃.
6. A Chinese medicinal composition for clearing heat and detoxicating comprises the Chinese medicinal materials as claimed in any one of claims 1-3.
7. The traditional Chinese medicine preparation according to claim 6, wherein: the dosage form of the traditional Chinese medicine preparation is selected from any one of the following: tablets, dispersible tablets, capsules, soft capsules, granules, pills, micropills, powders, dripping pills, decoctions, syrups, mixtures, oral liquid preparations, soft extracts and extract.
8. Use of a chinese patent medicine according to any one of claims 1-3 for the preparation of any one of the following products: clearing heat and detoxicating, and can be used for treating upper respiratory infection, pharyngitis and tonsillitis caused by pathogenic wind-heat evil and lung invasion and excessive heat evil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311508095.3A CN117257863A (en) | 2023-11-14 | 2023-11-14 | Trollium drop pill and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311508095.3A CN117257863A (en) | 2023-11-14 | 2023-11-14 | Trollium drop pill and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117257863A true CN117257863A (en) | 2023-12-22 |
Family
ID=89210809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311508095.3A Pending CN117257863A (en) | 2023-11-14 | 2023-11-14 | Trollium drop pill and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117257863A (en) |
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2023
- 2023-11-14 CN CN202311508095.3A patent/CN117257863A/en active Pending
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