CN112915195A - Smoking cessation paste and preparation method thereof - Google Patents
Smoking cessation paste and preparation method thereof Download PDFInfo
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- CN112915195A CN112915195A CN202110269179.0A CN202110269179A CN112915195A CN 112915195 A CN112915195 A CN 112915195A CN 202110269179 A CN202110269179 A CN 202110269179A CN 112915195 A CN112915195 A CN 112915195A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract
The smoking cessation paste comprises the following raw materials in parts by weight: 15-20 parts of houttuynia cordata total polysaccharide, 5-7 parts of earthworm protein extract, 3-5 parts of peppermint oil, 10-15 parts of eucommia ulmoides extract, 12-18 parts of fritillaria cirrhosa polysaccharide, 13-15 parts of ophiopogonin and 0.001-0.01 part of nicotine. The invention takes traditional Chinese medicinal materials as raw materials, extracts effective components to prepare a transdermal patch, absorbs the effective components through skin penetration, treats liver and kidney injury caused by long-term smoking, relieves discomfort caused by withdrawal reaction, promotes metabolism and discharge of harmful substances accumulated in the body, combines the harmful substances with nicotine receptors in the body by adding trace nicotine, and inhibits dopamine excitability feedback so as to achieve the purpose of quitting smoking.
Description
[ technical field ] A method for producing a semiconductor device
The invention belongs to the field of traditional Chinese medicine assisted smoking cessation, and particularly relates to smoking cessation paste and a preparation method thereof.
[ background of the invention ]
China is the biggest tobacco producing country and consumer country in the world, and 'smoking is harmful to health' becomes a world acknowledged statement, tobacco contains a large amount of nicotine, the nicotine is combined with nicotine receptors in the body to generate dopamine excitability feedback and produce smoking addiction, chemical harmful substances such as long-term smoking, tar, nicotine and benzene can be accumulated in the human body to cause great damage to the human body, people know the smoking harm or begin to try to quit smoking, China also quits smoking in public places such as hospitals and schools, and smoking also often becomes public nuisance. Many people are willing to quit smoking, but are difficult to quit with weak will, and are easy to have withdrawal reaction in the process of quitting smoking, patients with withdrawal reaction are clinically mainly manifested with subjective symptoms and objective physical signs, subjective symptoms such as nausea, vomiting, dizziness, headache, anorexia and the like, objective physical signs can be increased blood pressure, body temperature is high and the like.
For smokers who smoke for a long time, smoking cessation is difficult to succeed only by means of willpower, the probability of relapse is more than 70%, the damaged and long-term chemical harmful substances such as nicotine, tar, nicotine and benzene accumulated in the body after successful smoking cessation cannot be metabolized and discharged out of the body, and the damaged organs such as liver cannot be recovered quickly.
Therefore, the problem to be solved in the field is to provide the smoking cessation paste for assisting smoking cessation and repairing body injury and the preparation method thereof.
[ summary of the invention ]
Aiming at the problems, the invention provides a smoking cessation paste which takes traditional Chinese medicinal materials as raw materials, extracts effective components to prepare a transdermal patch, permeates and absorbs the effective components through skin, treats liver and kidney injuries caused by long-term smoking, relieves the discomfort caused by withdrawal reaction, promotes the metabolism and discharge of harmful substances accumulated in the body, combines the harmful substances with nicotine receptors in the body by adding trace nicotine, and inhibits the excitatory feedback of dopamine, thereby achieving the purpose of smoking cessation.
In order to solve the problems, the invention provides a smoking cessation paste which comprises the following raw materials in parts by weight: 15-20 parts of houttuynia cordata total polysaccharide, 5-7 parts of earthworm protein extract, 3-5 parts of peppermint oil, 10-15 parts of eucommia ulmoides extract, 12-18 parts of fritillaria cirrhosa polysaccharide, 13-15 parts of ophiopogonin and 0.001-0.01 part of nicotine.
Further, the smoking cessation paste comprises the following raw materials in parts by weight: the smoking cessation paste comprises the following raw materials in parts by weight: 18 parts of houttuynia cordata total polysaccharide, 6 parts of earthworm protein extract, 4 parts of peppermint oil, 13 parts of eucommia bark extract, 16 parts of fritillaria cirrhosa polysaccharide, 14 parts of ophiopogonin and 0.005 part of nicotine.
A method for preparing the smoking cessation paste applied to claim 1, which comprises the following steps:
the method comprises the following steps: pulverizing herba Houttuyniae, decocting with purified water, filtering, collecting filtrate, decocting the obtained residue with purified water, filtering, and mixing filtrates; filtering and retaining with ceramic membrane, collecting filtrate (reddish brown, clear and transparent), and concentrating to obtain herba Houttuyniae total polysaccharide extract;
step two: freeze drying Lumbricus, grinding, extracting with ethanol, ultrasonic treating, and filtering to obtain filtrate; concentrating the filtrate under reduced pressure, and drying to obtain crude extract of Lumbricus protein; dissolving the crude extract of Lumbricus protein in water, loading on MCI column, and collecting eluate; concentrating the eluate, eluting with methanol water solution, collecting eluate, and concentrating to obtain Lumbricus protein extract;
step three: mixing and pulping mint leaves, refrigerating, taking out, adding an ethanol solution, uniformly stirring, adjusting pH, circularly leaching to obtain an ethanol leaching solution and mint leaf residues, adding an ethyl acetate solution into the mint leaf residues, uniformly stirring, adjusting the pH, performing ultrasonic extraction, filtering, and taking filtrate to obtain an ethyl acetate extracting solution; mixing the ethanol extract and ethyl acetate extract, evaporating, and collecting oleum Menthae Dementholatum;
step four: placing folium Eucommiae in an extraction tank, adding softened water, soaking and extracting for several times, extracting the folium Eucommiae in water, precipitating the soaking solution with double salt, filtering with plate-frame filter, filtering to remove other impurities, desorbing with resin, and concentrating with steam to obtain cortex Eucommiae extract;
step five: taking bulbus fritillariae cirrhosae, drying and crushing, and extracting crushed bulbus fritillariae cirrhosae to obtain an extracting solution; adjusting pH, decolorizing, and filtering under reduced pressure to obtain filtrate; concentrating the filtrate under reduced pressure, adding ethanol, stirring, precipitating, washing the precipitate, and vacuum drying to obtain Bulbus Fritillariae Cirrhosae polysaccharide;
step six: cleaning radix Ophiopogonis, mincing, adding diastase, extracting with water, filtering to obtain residue and filtrate, concentrating the filtrate under reduced pressure, and extracting with ethyl acetate to obtain water phase and ethyl acetate phase; concentrating ethyl acetate phase under reduced pressure, eluting with ethanol solution to obtain eluate, concentrating the eluate under reduced pressure for crystallization, and filtering to obtain ophiopogonin;
step seven: adding nicotine with different dosages according to the smoking amount per day to prepare products with different specifications.
Furthermore, in the first step, two 500nm and 5nm ceramic membranes are adopted for filtration and interception, the pressure difference is adjusted to be 0.2Mpa, and the flow rate is adjusted to be 60L/h.
Further, in the third step, hydrochloric acid is used for regulating the pH value to 3.5 for the first time, sulfuric acid is used for regulating the pH value to 3.0 for the second time, the ethanol leaching solution and the ethyl acetate extracting solution are mixed and then are subjected to evaporation treatment for 90min at the temperature of 130 ℃, and the peppermint oil is collected.
Furthermore, in the fourth step, the compound salt, namely calcium hydroxide is 1 percent of the softened water, and ferric chloride is 1 per mill of the softened water.
Furthermore, in the fifth step, the extraction temperature is 47.3 ℃, the extraction pressure is 23.7MPa, the flow rate of the extracted carbon dioxide is 20-28L/h, the carrying agent is distilled water, the using amount is 390ml/kg, and the extraction is carried out for 2.5 h.
Further, the eluent in the sixth step is decompressed and concentrated to 1/15-1/30 at 50-60 ℃, and crystallized at 4-8 ℃.
Moreover, the smoking cessation paste takes traditional Chinese medicinal materials as raw materials, active ingredients are extracted to prepare a transdermal patch, the active ingredients are absorbed through skin penetration, liver and kidney injuries caused by long-term smoking are treated, discomfort caused by withdrawal reaction is relieved, metabolism and discharge of harmful substances accumulated in the body are promoted, and the patch is combined with nicotine receptors in the body by adding trace nicotine to inhibit dopamine excitability feedback, so that the aim of smoking cessation is fulfilled.
[ detailed description ] embodiments
The invention discloses a smoking cessation paste and a preparation method thereof, and the technical personnel in the field can use the contents of the invention for reference and properly improve the technological parameters for realization. It is expressly intended that all such similar substitutes and modifications which would be obvious to those skilled in the art are deemed to be included in the invention. While the method and application of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the method and application described herein may be made and equivalents employed without departing from the spirit and scope of the invention.
For a further understanding of the present invention, reference will now be made in detail to the following examples.
The smoking cessation paste comprises the following raw materials in parts by weight: 15-20 parts of houttuynia cordata total polysaccharide, 5-7 parts of earthworm protein extract, 3-5 parts of peppermint oil, 10-15 parts of eucommia ulmoides extract, 12-18 parts of fritillaria cirrhosa polysaccharide, 13-15 parts of ophiopogonin and 0.001-0.01 part of nicotine;
preferably, the smoking cessation paste comprises the following raw materials in parts by weight: 18 parts of houttuynia cordata total polysaccharide, 6 parts of earthworm protein extract, 4 parts of peppermint oil, 13 parts of eucommia bark extract, 16 parts of fritillaria cirrhosa polysaccharide, 14 parts of ophiopogonin and 0.005 part of nicotine;
houttuynia cordata: dried aerial part of houttuynia cordata Thunb of houttuynia of Saururaceae, has pungent taste and slightly cold nature; the traditional Chinese medicine composition is prepared from the components of the lung meridian, houttuynin, volatile oil, houttuynine, quercetin, potassium chloride and the like, and is mainly used for treating lung carbuncle and pus vomiting, lung heat cough: it is the essential herb for pulmonary abscess because it can purge and descend, pungent flavor can dissipate nodulation and enter lung meridian mainly to clear lung heat and relieve lung heat, and also has actions of resolving abscess and draining pus.
Earthworm: dried whole body of crinis cilianensis, common crinis cilianensis, crinis williamsii or crinis foetida of crinis of the lumbricaceae, contains various amino acids with highest content of glutamic acid, aspartic acid and leucine; contains microelements such as iron, zinc, magnesium and copper; contains arachidonic acid, succinic acid, etc. acid, and optionally Lumbricus alkali, Lumbricus essence, Lumbricus toxin, xanthine, hypoxanthine, guanine, choline, phospholipid, cholesterol, vitamins, protein, and enzymes, and has salty taste and cold property, and is suitable for liver and spleen; has effects of clearing heat, calming endogenous wind, dredging collaterals, relieving asthma, promoting urination, and lowering blood pressure.
Mint: is the aerial part of Mentha haplocalyx of Mentha of Labiatae, mainly contains volatile oil, the main ingredient of the oil is various components such as menthol, menthone, isomenthone, menthol, menthyl esters, etc., and also contains Isopterol, menthyl glycoside and various free amino acids, etc.; the tea has pungent taste and cool nature, enters lung and liver channels, and has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation;
eucommia ulmoides: is bark of eucommia ulmoides Oliver belonging to eucommia of Eucommiaceae, contains gutta Percha, eucommia ulmoides Oliver glycoside, pinoresinol diglucoside, aucubin, tannin, and flavonoid, has sweet taste and warm property, and enters liver and kidney channels; has effects in nourishing liver and kidney, strengthening muscle and bone, and preventing miscarriage.
Bulbus Fritillariae Cirrhosae: bulbus Fritillariae Cirrhosae, unibract fritillary bulb, Gansu fritillary bulb or Fritillaria fusiformis of Fritillaria of Liliaceae contains various alkaloids, such as Bulbus Fritillariae Cirrhosae containing peimine, Pinebicine A and Pinebicine B, and Bulbus Fritillariae Cirrhosae containing peimine and sipeimine. The Fritillaria unibracteata Hsiao et Hsia also contains pinto beining and sucrose, and the Fritillaria unibracteata Hsiao et Hsiao contains Min Bei Jia and Min Bei Yi; fritillaria comprises steine and steine, and has bitter and sweet taste, slightly cold property, and lung entering effect; has the effects of clearing heat, eliminating phlegm, moistening lung, relieving cough, resolving hard mass and relieving swelling.
Radix ophiopogonis: the Liliaceae Ophiopogon japonicus belongs to perennial evergreen herbaceous plant, contains steroid saponin, various polysaccharides, homoisoflavonoid compounds, monoterpene glycoside, chromone, etc., and has effects of promoting fluid production, quenching thirst, moistening lung, and relieving cough. Can be used for treating dry cough due to lung dryness, tuberculosis due to yin deficiency, sore throat, pharyngalgia, thirst due to body fluid consumption, diabetes due to internal heat, vexation, insomnia, and constipation due to intestinal dryness.
The preparation method of the smoking cessation paste comprises the following steps:
the method comprises the following steps: preparing houttuynia cordata total polysaccharide
Chopping and crushing a commercially available dried houttuynia cordata, sieving the chopped houttuynia cordata with a 60-100-mesh sieve, adding purified water, decocting the crushed houttuynia cordata in a heating tank for 1 hour, filtering the decoction with fine gauze, collecting filtrate, adding the obtained filter residue into the purified water, decocting the decoction in the heating tank for 1 hour, filtering the decoction with the fine gauze, and combining the two filtrates; filtering and retaining with 500nm and 5nm ceramic membranes, adjusting pressure difference to 0.2Mpa and flow rate to 60L/h, collecting filtrate (reddish brown, clear and transparent), and concentrating the filtrate to obtain herba Houttuyniae total polysaccharide extract;
step two: preparing Lumbricus protein extract
Freeze drying clean fresh Lumbricus at-20 deg.C, rapidly grinding in liquid nitrogen environment, adding anhydrous ethanol, soaking and extracting at room temperature for 24 hr, treating with ultrasound (40KHz) for 3 hr, and filtering to obtain filtrate; repeating the soaking extraction and ultrasonic treatment for 2 times, mixing the filtrates obtained 3 times, concentrating the filtrate under reduced pressure, recovering ethanol, and drying to obtain crude Lumbricus protein extract; dissolving the crude earthworm protein extract in water, loading the earthworm protein extract on an MCI (methanol to oil) column, washing the column by using 90% methanol aqueous solution in volume concentration, and collecting eluent; concentrating the eluate, loading on Sephadex LH-20, eluting with 90% methanol water solution, collecting eluate, and concentrating to obtain Lumbricus protein extract.
Step three: extracting oleum Menthae Dementholatum
Mixing fresh folium Menthae, pulping, placing into a refrigerator, refrigerating, taking out, adding 84% ethanol solution, stirring, adding hydrochloric acid to adjust pH to 3.5, circularly leaching at 44 deg.C for 200min to obtain ethanol leaching solution and folium Menthae residue; adding 63% by mass of ethyl acetate solution into folium Menthae residue, stirring, adding sulfuric acid to adjust pH to 3.0, performing ultrasonic extraction at 39 deg.C, filtering, and collecting filtrate to obtain ethyl acetate extract; mixing ethanol extractive solution and ethyl acetate extractive solution, evaporating at 130 deg.C for 90min, and collecting oleum Menthae Dementholatum;
step four: extracting cortex Eucommiae extract
Placing selected folium Eucommiae into an extraction tank, adding softened water 6 times of folium Eucommiae, heating to 60 deg.C, soaking and extracting for three times, extracting the folium Eucommiae into water, precipitating the soaking solution with double salt (calcium hydroxide is 1% of the softened water and ferric chloride is 1 ‰ of the softened water), enlarging impurity molecules of the folium Eucommiae, filtering with a plate frame, filtering out other impurities, adsorbing and desorbing with resin, and concentrating with steam to obtain cortex Eucommiae extract;
step five: preparation of Bulbus Fritillariae Cirrhosae polysaccharide
Taking and drying the bulbus fritillariae cirrhosae, crushing the bulbus fritillariae cirrhosae into powder with the particle size smaller than 60 meshes, putting the crushed bulbus fritillariae cirrhosae into a supercritical CO2 extraction kettle, sealing the kettle, removing air, introducing a carrying agent for extraction to obtain an extracting solution, wherein the extraction temperature is 47.3 ℃, the extraction pressure is 23.7MPa, the flow rate of extraction carbon dioxide is 20-28L/h, the carrying agent is distilled water, the using amount is 390ml/kg, and the extraction is carried out for 2.5 h; adjusting pH of the obtained extractive solution to 7.8 with 1mol/L NaOH, adding diatomaceous earth, boiling for 5min for decolorizing, and filtering under reduced pressure to obtain filtrate; concentrating the obtained filtrate under reduced pressure in 75 deg.C water bath to 30% of the original volume, adding 4 times of 95 wt% ethanol, stirring, centrifuging at 3000r/min for 10min to obtain precipitate I, washing the precipitate I with anhydrous ethanol and diethyl ether, and vacuum drying to obtain Bulbus Fritillariae Cirrhosae polysaccharide;
step six: extracting ophiopogonin
Cleaning and mincing radix ophiopogonis, adding glucoamylase into the solution to enable the enzyme activity in the solution to reach more than 200U/L, and carrying out enzymolysis for 1.5-3 h at 50-60 ℃; adding water, leaching for 1.5-3 h at 90-100 ℃, and filtering to obtain filter residue and filtrate, wherein the weight kg ratio of the added water L to the radix ophiopogonis is 4-8: 1; concentrating the filtrate at 50-60 ℃ under reduced pressure to 1/10-1/20, adding ethyl acetate with two to four times volume of the filtrate, stirring and extracting for 30-60 min, and standing for 8-12 h to obtain a water phase and an ethyl acetate phase; concentrating the ethyl acetate phase at 50-60 ℃ under reduced pressure to 1/10-1/20, loading the ethyl acetate phase on an S-8 column, eluting the ethyl acetate phase with 30% ethanol solution with four to six times of column volume to obtain eluent, concentrating the eluent at 50-60 ℃ under reduced pressure to 1/15-1/30, crystallizing at 4-8 ℃, and filtering to obtain an ophiopogonin product;
step seven: adding nicotine with different dosages according to the smoking amount per day to prepare products with different specifications;
mixing the herba Houttuyniae total polysaccharide, Lumbricus protein extract, oleum Menthae Dementholatum, Eucommiae cortex extract, Bulbus Fritillariae Cirrhosae polysaccharide, radix Ophiopogonis saponin and nicotine to obtain extract, and uniformly spreading the extract on medical adhesive tape to obtain transdermal patch, wherein transdermal patches with different specifications are selected according to user's own condition; the method specifically comprises the following three specifications:
(1)10cm2: 17.5 mg: i.e. the smoking cessation patch 10, the average speed of the active substance release to the skin is 7mg/24 hours;
(2)20cm2: 35.0 mg: i.e. the smoking cessation patch 20, which releases the active substance to the skin at an average rate of 14mg/24 hours;
(3)30cm2: 52.5 mg/: i.e., a patch 30 for giving up smoking, which has an average rate of release of the active substance to the skin of 21mg/24 hours;
applying the smoking cessation paste 30 to smokers who smoke more than 20 cigarettes per day; the smoking quitting patch 20 is used for smokers who smoke no more than 20 cigarettes per day. The patch 10 is used at the end of the treatment when the dosage is reduced.
The smoking cessation paste is prepared by extracting effective components from traditional Chinese medicinal materials as raw materials to prepare a transdermal patch, the effective components are absorbed through skin penetration, liver and kidney injuries caused by long-term smoking are treated, discomfort caused by withdrawal reaction is relieved, metabolism and discharge of harmful substances accumulated in the body are promoted, and the patch is combined with nicotine receptors in the body by adding trace nicotine to inhibit dopamine excitability feedback, so that the aim of smoking cessation is fulfilled.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (8)
1. The smoking cessation paste is characterized by comprising the following raw materials in parts by weight: 15-20 parts of houttuynia cordata total polysaccharide, 5-7 parts of earthworm protein extract, 3-5 parts of peppermint oil, 10-15 parts of eucommia ulmoides extract, 12-18 parts of fritillaria cirrhosa polysaccharide, 13-15 parts of ophiopogonin and 0.001-0.01 part of nicotine.
2. The smoking cessation paste as claimed in claim 1, wherein the smoking cessation paste comprises the following raw materials in parts by weight: the smoking cessation paste comprises the following raw materials in parts by weight: 18 parts of houttuynia cordata total polysaccharide, 6 parts of earthworm protein extract, 4 parts of peppermint oil, 13 parts of eucommia bark extract, 16 parts of fritillaria cirrhosa polysaccharide, 14 parts of ophiopogonin and 0.005 part of nicotine.
3. A method for preparing the smoking cessation paste applied to claim 1, which comprises the following steps:
the method comprises the following steps: pulverizing herba Houttuyniae, decocting with purified water, filtering, collecting filtrate, decocting the obtained residue with purified water, filtering, and mixing filtrates; filtering and retaining with ceramic membrane, collecting filtrate (reddish brown, clear and transparent), and concentrating to obtain herba Houttuyniae total polysaccharide extract;
step two: freeze drying Lumbricus, grinding, extracting with ethanol, ultrasonic treating, and filtering to obtain filtrate; concentrating the filtrate under reduced pressure, and drying to obtain crude extract of Lumbricus protein; dissolving the crude extract of Lumbricus protein in water, loading on MCI column, and collecting eluate; concentrating the eluate, eluting with methanol water solution, collecting eluate, and concentrating to obtain Lumbricus protein extract;
step three: mixing and pulping mint leaves, refrigerating, taking out, adding an ethanol solution, uniformly stirring, adjusting pH, circularly leaching to obtain an ethanol leaching solution and mint leaf residues, adding an ethyl acetate solution into the mint leaf residues, uniformly stirring, adjusting the pH, performing ultrasonic extraction, filtering, and taking filtrate to obtain an ethyl acetate extracting solution; mixing the ethanol extract and ethyl acetate extract, evaporating, and collecting oleum Menthae Dementholatum;
step four: placing folium Eucommiae in an extraction tank, adding softened water, soaking and extracting for several times, extracting the folium Eucommiae in water, precipitating the soaking solution with double salt, filtering with plate-frame filter, filtering to remove other impurities, desorbing with resin, and concentrating with steam to obtain cortex Eucommiae extract;
step five: taking bulbus fritillariae cirrhosae, drying and crushing, and extracting crushed bulbus fritillariae cirrhosae to obtain an extracting solution; adjusting pH, decolorizing, and filtering under reduced pressure to obtain filtrate; concentrating the filtrate under reduced pressure, adding ethanol, stirring, precipitating, washing the precipitate, and vacuum drying to obtain Bulbus Fritillariae Cirrhosae polysaccharide;
step six: cleaning radix Ophiopogonis, mincing, adding diastase, extracting with water, filtering to obtain residue and filtrate, concentrating the filtrate under reduced pressure, and extracting with ethyl acetate to obtain water phase and ethyl acetate phase; concentrating ethyl acetate phase under reduced pressure, eluting with ethanol solution to obtain eluate, concentrating the eluate under reduced pressure for crystallization, and filtering to obtain ophiopogonin;
step seven: adding nicotine with different dosages according to the smoking amount per day to prepare products with different specifications.
4. The preparation method of the smoking cessation paste as claimed in claim 3, wherein two 500nm and 5nm ceramic membranes are adopted for filtration and retention in the first step, the pressure difference is adjusted to 0.2Mpa, and the flow rate is 60L/h.
5. The method for preparing paste for stopping smoking according to claim 3, wherein hydrochloric acid is used for adjusting pH to 3.5 in the first step, sulfuric acid is used for adjusting pH to 3.0 in the second step, the ethanol extract and the ethyl acetate extract are mixed, and then the mixture is subjected to evaporation treatment at 130 ℃ for 90min, and peppermint oil is collected.
6. The method for preparing paste for stopping smoking according to claim 3, wherein the compound salt in the fourth step is calcium hydroxide 1% of the softened water, and ferric chloride 1% of the softened water.
7. The preparation method of the smoking cessation paste as claimed in claim 3, wherein in the fifth step, the extraction temperature is 47.3 ℃, the extraction pressure is 23.7MPa, the flow rate of the extracted carbon dioxide is 20-28L/h, the carrying agent is distilled water, the dosage is 390ml/kg, and the extraction is carried out for 2.5 h.
8. The preparation method of the smoking cessation paste as claimed in claim 3, wherein the eluent in the sixth step is concentrated to 1/15-1/30 under reduced pressure at 50-60 ℃, and crystallized at 4-8 ℃.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173329A (en) * | 1996-08-13 | 1998-02-18 | 李建民 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
| CN1468606A (en) * | 2002-07-16 | 2004-01-21 | 王 蓝 | Smoking-quiting gettama cigarette |
| CN104189446A (en) * | 2014-08-13 | 2014-12-10 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicinal smoking cessation buccal tablet |
-
2021
- 2021-03-12 CN CN202110269179.0A patent/CN112915195A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173329A (en) * | 1996-08-13 | 1998-02-18 | 李建民 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
| CN1468606A (en) * | 2002-07-16 | 2004-01-21 | 王 蓝 | Smoking-quiting gettama cigarette |
| CN104189446A (en) * | 2014-08-13 | 2014-12-10 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicinal smoking cessation buccal tablet |
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