CN101491650B - Refined Yinqiao detoxification preparation and preparation method thereof - Google Patents
Refined Yinqiao detoxification preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a refined lonicera-forsythia alexipharmic preparation, which is prepared by the following method: paracetamol and ballonflower are ground into fine powder respectively; schizonepeta spike is ground to be between 10 and 20 mesh, and then volatile oil is extracted; nepeta oil and menthol are dissolved in a proper amount of ethanol; the rest of medicines is added with water, decocted twice and filtered; filtrate is concentrated, dried and ground so as to obtain dry extract powder; the dry extract powder, the fine ballonflower powder, the fine paracetamol powder and subsidiary substances are granulated, added with a nepeta-oil ethanol solution and a menthol ethanol solution, well mixed and made into various orally-administrated preparations. In the refined lonicera-forsythia alexipharmic preparation, the nepeta oil as the component of the volatile oil is stable in content and beneficial to the stable quality of the preparation and the curative effect enhancement of the medicines. The invention also discloses a method for preparing the refined lonicera-forsythia alexipharmic preparation. The method is beneficial to the leaching of the volatile oil in medicinal materials so as to greatly improve the yield of the volatile oil, and has the advantages of improving the leaching rate of volatile active components, obviously increasing the content of effective substances in preparation products and strengthening the therapeutic effects of the medicines.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, particularly a kind of refined lonicera-forsythia alexipharmic preparation and preparation method thereof.
Background technology
Refined Yin Qiao antidotal tablet records in the 198th page of " Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government " (the 3rd); With acetaminophen (72g), Radix Platycodonis (120g), Fructus Forsythiae (200g), Semen Sojae Preparatum (100g), Radix Glycyrrhizae (100g), Herba Lophatheri (80g), Flos Lonicerae (200g), Fructus Arctii (120g), Herba Schizonepetae (80g), Mentholum (0.6g) is raw material; Make through the following method of stating: acetaminophen, Radix Platycodonis pulverize separately become fine powder; Extracting volatile oil from schizonepeta spike is used an amount of dissolve with ethanol with Herba Schizonepetae spike oil, Mentholum; Six-element decocte with water secondaries such as all the other Fructus Forsythiaes filter, merging filtrate, and filtrating is condensed into cream; Add Radix Platycodonis, acetaminophen powder and right amount of auxiliary materials, mixing is processed granule, oven dry; Put coldly, add Herba Schizonepetae spike oil, Mentholum alcoholic solution, mixing, should go out granule number is 408g; Tabletting, sugar coating promptly gets.
In prescription, Herba Schizonepetae is the dry spica of labiate Herba Schizonepetae Schizonepetatenuifolia Briq., is one of clinical pungent and warm medicine for relieving the exterior syndrome commonly used; Its slightly warm in nature, acrid in the mouth is gone into the liver lung meridian; Effect with expelling pathogenic wind from the body surface, the malicious rash of a surname; Cure mainly anemofrigid cold, laryngopharynx swelling and pain, headache, rubella, measles, skin infection from the beginning of etc. various skin sick, be the tcm clinical practice common drug.Herba Schizonepetae is rich in volatile oil, and the main effective ingredient in its volatile oil is terpenoids such as menthone, pulegone, and wherein menthone has very strong analgesic activity, and pulegone has effects such as antiinflammatory.Herba Schizonepetae volatile oil has analgesia, antiinflammation, simultaneously aspects such as smooth muscle, heart and central nervous system is also had certain influence.
Among the preparation technology of existing refined Yin Qiao antidotal tablet, be that the Herba Schizonepetae medical material is added the water distillation, distil process laid down by imprecision causes the volatile oil yield low, of poor quality, has influenced the quality of product and the drug effect of medicine.And this technology is wayward in process of production, is unfavorable for big production; Volatile ingredient is prone to loss, has influence on the clinical efficacy of medicine.Therefore rationally extract Herba Schizonepetae and improve the content of its active component and the stability in product has important meaning to improving drug effect.
Summary of the invention
Main purpose of the present invention provides a kind of refined lonicera-forsythia alexipharmic preparation, and the effective ingredient stable content of volatile ingredient Herba Schizonepetae oil particularly in the said preparation helps the steady quality and the medicament curative effect enhancement of preparation.
Another object of the present invention provides a kind of method for preparing of above-mentioned refined lonicera-forsythia alexipharmic preparation, through the Herba Schizonepetae medical material is carried out special handling before extraction, improves the leaching rate of volatile oil, medicament curative effect enhancement.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of refined lonicera-forsythia alexipharmic preparation makes through the method that comprises following key step:
(1), pulverizes acetaminophen and Radix Platycodonis: the acetaminophen of formula ratio is become fine powder with the Radix Platycodonis pulverize separately;
(2), extract Herba Schizonepetae oil: the Herba Schizonepetae of formula ratio is crushed to 10 orders～20 orders, after 30 minutes, discards water with 10 times of medical material water gagings immersions, directly logical Steam Heating is collected Aromatic water, carries to distinguishing the flavor of to the greatest extent, and Aromatic water obtains Herba Schizonepetae oil after making with extra care;
(3), dissolving Herba Schizonepetae oil and Mentholum: the Mentholum of the Herba Schizonepetae oil in above-mentioned (2) step and formula ratio is used an amount of ethanol respectively, and (concentration is the ethanol more than 90%; Its consumption is 1: 3～5 to be advisable with solute (Herba Schizonepetae oil or Mentholum) and alcoholic acid part by weight) dissolving, Herba Schizonepetae oil alcoholic solution and Mentholum alcoholic solution;
(4), extract all the other medicines: get Fructus Forsythiae, Semen Sojae Preparatum, Radix Glycyrrhizae, Herba Lophatheri, Flos Lonicerae, the Fructus Arctii of formula ratio, drop in the extraction pot, add 6 times of water gagings for the first time, soak 2h, decoct and extract 2h, filter; Add for the second time 5 times of water gagings, decoct and extract 1.5h, it is 1.28g/ml～1.35g/ml (60 ℃ of surveys) that filtrate decompression is concentrated into proportion, goes out cream; 70～80 ℃ of control temperature, vacuum-0.06MPa～-0.09Mpa, drying under reduced pressure with broken mistake 80 orders of dried cream powder, gets the mixture dried cream powder;
(5), process preparation: in above-mentioned (4) the mixture dried cream powder in step, add (1) Radix Platycodonis and the Paracetamol BP Fine Powder in step, add an amount of pharmaceutic adjuvant, mixing; Granulate, add (3) the Herba Schizonepetae oil alcoholic solution and the Mentholum alcoholic solution in step again, mixing; Process various oral formulations, promptly get.
When processing preparation, can in above-mentioned (4) dried cream powder in step, add (1) Radix Platycodonis and the Paracetamol BP Fine Powder in step, add appropriate amount of auxiliary materials, mixing is processed granule, and oven dry is put cold; Add above-mentioned (3) the Herba Schizonepetae oil alcoholic solution and the Mentholum alcoholic solution in step again, mixing can direct packaging make granule, makes capsule in the capsulae vacuus of perhaps packing into, and perhaps further tabletting, coating make tablet etc.
In the method for preparing of above-mentioned refined lonicera-forsythia alexipharmic preparation, adopt, increased the surface area of medical material, make the volatile oil yield greatly improve, improved the leaching rate of volatility active component simultaneously, strengthened the therapeutic effect of medicine extracting volatile oil after the pulverizing medicinal materials.
Show through long term test and detection: the stable content of volatile ingredient Herba Schizonepetae oil in the said preparation helps the steady quality and the medicament curative effect enhancement of preparation.
Refined lonicera-forsythia alexipharmic preparation of the present invention has clearing away heat to dispel wind, the effect such as bring down a fever of inducing sweat; Can be used for treating influenza, the fever of feeling cold, extremity are listless and aching, headache cough, laryngopharynx swelling and pain etc.
Compared with prior art, the invention has the beneficial effects as follows:
In the refined lonicera-forsythia alexipharmic preparation of the present invention, the stable content of volatile ingredient Herba Schizonepetae oil helps the steady quality and the medicament curative effect enhancement of preparation.
On the other hand; The method for preparing of the above-mentioned refined lonicera-forsythia alexipharmic preparation of the present invention is simple, through the Herba Schizonepetae medical material is carried out pulverization process before extraction, has increased the surface area of medical material; Help the leaching of volatile oil in the medical material; Make the volatile oil yield greatly improve, can improve the leaching rate of volatility active component simultaneously, obviously improve the content and the therapeutic effect that strengthens medicine of active substance in the product formulation.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is made further detailed description.
But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.
Embodiment 1
Present embodiment is refined Yin Qiao antidotal tablet (specification: every contains acetaminophen 44mg)
Its raw material consists of:
Acetaminophen (72g), Radix Platycodonis (120g), Fructus Forsythiae (200g), Semen Sojae Preparatum (100g), Radix Glycyrrhizae (100g), Herba Lophatheri (80g), Flos Lonicerae (200g), Fructus Arctii (120g), Herba Schizonepetae (80g), Mentholum (0.6g).(making granule 408g altogether, about 1636)
Method through comprising following key step makes:
(1), pulverizes acetaminophen and Radix Platycodonis: the acetaminophen of formula ratio is become fine powder with the Radix Platycodonis pulverize separately;
(2), extract the Herba Schizonepetae spike oil: the Herba Schizonepetae of formula ratio is pulverized the Herba Schizonepetae of formula ratio was pulverized 10 orders, soak 30 minutes with 10 times of water gagings after, discard water, directly logical Steam Heating is collected Aromatic water, carry to flavor to the greatest extent, promptly obtain Herba Schizonepetae oil after Aromatic water is refining;
(3), dissolving Herba Schizonepetae oil and Mentholum: the Herba Schizonepetae oil in above-mentioned (2) step and the Mentholum of formula ratio are used 3 times of 90% dissolve with ethanol respectively, get Herba Schizonepetae oil alcoholic solution and Mentholum alcoholic solution;
(4), extract all the other medicines: with Fructus Forsythiae, Semen Sojae Preparatum, Radix Glycyrrhizae, Herba Lophatheri, Flos Lonicerae, Fructus Arctii, drop in the extraction pot, add 6 times of amount drinking waters for the first time, soak 2h, decoct and extract 2h, filter in the prescription ratio; Add for the second time 5 times of amount drinking waters, decoct and extract 1.5h, it is 1.28g/ml (60 ℃ of surveys) that filtrate decompression is concentrated into proportion, goes out cream; 70～80 ℃ of control temperature, vacuum-0.06MPa～-0.09Mpa, drying under reduced pressure with broken mistake 80 orders of dried cream powder, gets the mixture dried cream powder;
(5), process preparation: in above-mentioned (4) the mixture dried cream powder in step, add (1) the Radix Platycodonis fine powder and the Paracetamol BP Fine Powder in step, add the starch of 0.05g/ sheet, mixing; Add 85% ethanol and make suitable soft material; 16 mesh sieves are granulated, 60～70 ℃ of dryings, 16 mesh sieve granulate; Add above-mentioned (3) the Herba Schizonepetae oil alcoholic solution and the Mentholum alcoholic solution in step again, the micropowder silica gel of adding 1% and 0.5% magnesium stearate, mixing, check acetaminophen content, tabletting, coating, packing promptly gets refined Yin Qiao antidotal tablet.
Embodiment 2
Present embodiment is refined Yinqiao detoxification granule (specification: 15g/ bag, every bag contains acetaminophen 44mg)
Its raw material consists of:
Acetaminophen (72g), Radix Platycodonis (120g), Fructus Forsythiae (200g), Semen Sojae Preparatum (100g), Radix Glycyrrhizae (100g), Herba Lophatheri (80g), Flos Lonicerae (200g), Fructus Arctii (120g), Herba Schizonepetae (80g), Mentholum (0.6g).
Method through comprising following key step makes:
(1), pulverizes acetaminophen and Radix Platycodonis: the acetaminophen of formula ratio is become fine powder with the Radix Platycodonis pulverize separately;
(2), extract the Herba Schizonepetae spike oil: the Herba Schizonepetae of formula ratio was pulverized 10 orders～20 orders, after 30 minutes, discard water with 10 times of water gagings immersions, directly logical Steam Heating is collected Aromatic water, carries to distinguishing the flavor of to the greatest extent, and Aromatic water promptly obtains Herba Schizonepetae oil after making with extra care;
(3), dissolving Herba Schizonepetae oil and Mentholum: the Herba Schizonepetae oil in above-mentioned (2) step and the Mentholum of formula ratio are used 5 times of 95% dissolve with ethanol respectively, get Herba Schizonepetae oil alcoholic solution and Mentholum alcoholic solution;
(4), extract all the other medicines: with Fructus Forsythiae, Semen Sojae Preparatum, Radix Glycyrrhizae, Herba Lophatheri, Flos Lonicerae, Fructus Arctii, drop in the extraction pot, add 6 times of amount drinking waters for the first time, soak 2h, decoct and extract 2h, filter in the prescription ratio; Add for the second time 5 times of amount drinking waters, decoct and extract 1.5h, it is 1.35g/ml (60 ℃ of surveys) that filtrate decompression is concentrated into proportion, goes out cream; 70～80 ℃ of control temperature, vacuum-0.06MPa～-0.09Mpa, drying under reduced pressure with broken mistake 80 orders of dried cream powder, gets the mixture dried cream powder;
(5), process preparation: in above-mentioned (4) the mixture dried cream powder in step, add (1) the Radix Platycodonis fine powder and the Paracetamol BP Fine Powder in step, add the Icing Sugar of 14.8g/ bag, mixing adds 65% ethanol and makes suitable soft material; 16 mesh sieves are granulated, and 60～70 ℃ of dryings are with 12 orders and 60 mesh sieves choosing grain; Add above-mentioned (3) the Herba Schizonepetae oil alcoholic solution and the Mentholum alcoholic solution in step again, mixing, check acetaminophen content; Fill, packing promptly gets the refined Yinqiao detoxification granule.
Embodiment 3
Present embodiment is refined Yinqiao detoxification capsule (specification: 0.3g/ grain, every contains acetaminophen 44mg)
Its raw material consists of:
Acetaminophen (72g), Radix Platycodonis (120g), Fructus Forsythiae (200g), Semen Sojae Preparatum (100g), Radix Glycyrrhizae (100g), Herba Lophatheri (80g), Flos Lonicerae (200g), Fructus Arctii (120g), Herba Schizonepetae (80g), Mentholum (0.6g).
Method through comprising following key step makes:
(1), pulverizes acetaminophen and Radix Platycodonis: the acetaminophen of formula ratio is become fine powder with the Radix Platycodonis pulverize separately;
(2), extract the Herba Schizonepetae spike oil: the Herba Schizonepetae of formula ratio was pulverized 10 orders～20 orders, after 30 minutes, discard water with 10 times of water gagings immersions, directly logical Steam Heating is collected Aromatic water, carries to distinguishing the flavor of to the greatest extent, and Aromatic water promptly obtains Herba Schizonepetae oil after making with extra care;
(3), dissolving Herba Schizonepetae oil and Mentholum: the Herba Schizonepetae oil in above-mentioned (2) step and the Mentholum of formula ratio are used 4 times of anhydrous alcohol solutions respectively, get Herba Schizonepetae oil alcoholic solution and Mentholum alcoholic solution;
(4), extract all the other medicines: with Fructus Forsythiae, Semen Sojae Preparatum, Radix Glycyrrhizae, Herba Lophatheri, Flos Lonicerae, Fructus Arctii, drop in the extraction pot, add 6 times of amount drinking waters for the first time, soak 2h, decoct and extract 2h, filter in the prescription ratio; Add for the second time 5 times of amount drinking waters, decoct and extract 1.5h, filtrate decompression is concentrated into proportion 1.30g/ml (60 ℃ of surveys) and goes out cream; 70～80 ℃ of control temperature, vacuum-0.06MPa～-0.09Mpa, drying under reduced pressure with broken mistake 80 orders of dried cream powder, gets the mixture dried cream powder;
(5), process preparation: in above-mentioned (4) the mixture dried cream powder in step, add (1) the Radix Platycodonis fine powder and the Paracetamol BP Fine Powder in step, add the starch of 0.1g/ grain, mixing sprays into purified water and makes granule, 60～70 ℃ of dryings, 20 mesh sieve granulate; Add above-mentioned (3) the Herba Schizonepetae oil alcoholic solution and the Mentholum alcoholic solution in step again, the micropowder silica gel of adding 0.5% and 0.5% magnesium stearate, mixing, check acetaminophen content, the fill capsule, packing promptly gets the refined Yinqiao detoxification capsule.
Volatile oil yield after the inventor extracts Herba Schizonepetae volatile oil in the foregoing description 1～3 detects, and compares with the volatile oil yield of traditional extraction method gained.The gained correction data is following:
| Project | The tradition extraction method | Extraction method of the present invention (embodiment 1～3) |
| Volatile oil yield (%) | 0.5～0.65 | 0.8～1.2 |
It is thus clear that: the yield of volatile oil greatly improves among the present invention, correspondingly, can improve the leaching rate of volatility active component, improves the content and the therapeutic effect that strengthens medicine of active substance in the product formulation.
Claims (2)
1. the method for preparing of a refined lonicera-forsythia alexipharmic preparation comprises following key step:
(1), pulverizes acetaminophen and Radix Platycodonis: the acetaminophen of formula ratio is become fine powder with the Radix Platycodonis pulverize separately;
(2), extract Herba Schizonepetae oil: the Herba Schizonepetae of formula ratio is crushed to 10 orders～20 orders, after 30 minutes, discards water with 10 times of water gagings immersions, directly logical Steam Heating is collected Aromatic water, carries to distinguishing the flavor of to the greatest extent, and Aromatic water obtains Herba Schizonepetae oil after making with extra care;
(3), dissolving Herba Schizonepetae oil and Mentholum: it is the dissolve with ethanol more than 90% that the Mentholum of the Herba Schizonepetae oil in above-mentioned (2) step and formula ratio is used concentration respectively; Its consumption is Herba Schizonepetae oil/Mentholum and alcoholic acid part by weight 1:3～5, gets Herba Schizonepetae oil alcoholic solution and Mentholum alcoholic solution;
(4), extract all the other medicines: get Fructus Forsythiae, Semen Sojae Preparatum, Radix Glycyrrhizae, Herba Lophatheri, Flos Lonicerae, the Fructus Arctii of formula ratio, drop in the extraction pot, add 6 times of water gagings for the first time, soak 2h, decoct and extract 2h, filter; Add for the second time 5 times of water gagings, decoct and extract 1.5h, proportion was 1.28g/ml～1.35g/ml when filtrate decompression was concentrated into 60 ℃, went out cream; 70～80 ℃ of control temperature, vacuum-0.06MPa～-0.09Mpa, drying under reduced pressure with broken mistake 80 orders of dried cream powder, gets the mixture dried cream powder;
(5), process preparation: in above-mentioned (4) the mixture dried cream powder in step, add (1) Radix Platycodonis and the Paracetamol BP Fine Powder in step, add pharmaceutic adjuvant, mixing; Granulate, add (3) the Herba Schizonepetae oil alcoholic solution and the Mentholum alcoholic solution in step again, mixing; Process various oral formulations, promptly get.
2. the method for preparing of a kind of refined lonicera-forsythia alexipharmic preparation according to claim 1 is characterized in that, described preparation is any one or a few in tablet, capsule, the granule.
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| CN114588199B (en) * | 2020-12-04 | 2023-10-24 | 海图生物科技(上海)有限责任公司 | A fructus forsythiae extract, and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1014677B (en) * | 1990-02-10 | 1991-11-13 | 北京市东风制药厂 | Preparing process of snore-stopping medicine |
| CN1709366A (en) * | 2005-06-24 | 2005-12-21 | 王衡新 | Chinese medicine formulation for dispelling wind, diaphoresis and expelling toxin by cooling, and its preparing method |
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2008
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1014677B (en) * | 1990-02-10 | 1991-11-13 | 北京市东风制药厂 | Preparing process of snore-stopping medicine |
| CN1709366A (en) * | 2005-06-24 | 2005-12-21 | 王衡新 | Chinese medicine formulation for dispelling wind, diaphoresis and expelling toxin by cooling, and its preparing method |
Non-Patent Citations (2)
| Title |
|---|
| WS3-B-0660-91.精制银翘解毒片.《部颁中药成方制剂》.卫生部颁药品标准,1991,第三册、第198页. * |
| 栾伟丽等.荆芥挥发油提取方法的研究.《江西化工》.2006,(第2期),7-9. * |
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