CN105816699A - Sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and preparation method thereof - Google Patents
Sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and preparation method thereof Download PDFInfo
- Publication number
- CN105816699A CN105816699A CN201610176059.5A CN201610176059A CN105816699A CN 105816699 A CN105816699 A CN 105816699A CN 201610176059 A CN201610176059 A CN 201610176059A CN 105816699 A CN105816699 A CN 105816699A
- Authority
- CN
- China
- Prior art keywords
- parts
- wulf
- oral liquid
- sparassia crispa
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and a preparation method thereof. The healthcare oral liquid is prepared from, by mass, 30-40 parts of sparassis crispa, 5-10 parts of selfheal, 5-8 parts of white chrysanthemum flowers, 3-5 parts of Shandong hawthorn fruits, 3-7 parts of corn stigma, 5-10 parts of uncaria, 5-7 parts of apocynum venetum, 3-5 parts of ground beetles, 3-7 parts of oriental wormwood, 4-7 parts of kelp, 5-10 parts of processed honey and 5-10 parts of flavoring agent. According to the oral liquid, the sparassis crispa serves as a main ingredient to be compounded with uncaria, apocynum venetum, white chrysanthemum flowers, selfheal, Shandong hawthorn fruits, kelp, oriental wormwood, ground beetles and corn stigma, and the oral liquid has the effects of clearing liver heat and dissipating internal heat, subsiding swelling and prompting urination, protecting the liver and benefiting the gallbladder, reducing blood pressure and blood lipid and the like and further has the healthcare effects of resisting inflammation, resisting tumors, cancer, oxidation and aging, enhancing immunity and the like.
Description
Technical field
The present invention relates to health product technology field, Sparassia crispa (Wulf.) Fr. health care oral liquid being specifically related to a kind of blood fat-reducing blood pressure-decreasing and preparation method thereof.
Background technology
Sparassia crispa (Wulf.) Fr., has another name called silk ball mushroom, and Classification system is Sparassiscrispa, is non-pleat pore fungi mesh, silk ball Cordycepps, silk ball Pseudomonas.Sparassia crispa (Wulf.) Fr. is famous and precious food medicine dual-purpose bacterium, is described as " kings of ten thousand mushrooms ", because it has the activation immunocompetence of superelevation, the title of " the magical mushroom of illusion " is had in Japan, common mushroom growth is at the back, and silk ball mushroom needs the irradiation of more than 10h every day, is unique " sunlight mushroom " in the world.Sparassia crispa (Wulf.) Fr. contains substantial amounts of protein, carbohydrate, multivitamin, several amino acids and dietary fiber and ash, mineral etc..Wherein, Sparassia crispa (Wulf.) Fr. contains substantial amounts of beta glucan, and beta glucan is a kind of bioactive substance, has immunomodulating, antitumor, antiinflammatory, antiviral, antioxidation, radioprotective, blood sugar lowering, blood fat reducing, protects the liver, improves the several functions such as hemopoietic function；Vitamin E, vitamin C in Sparassia crispa (Wulf.) Fr. have antioxidation；Sparassia crispa (Wulf.) Fr. can be changed into vitamin D under sunlight and ultraviolet irradiate possibly together with ergosterol, ergosterol, promote calcium, the formation of the absorption of phosphorus, beneficially skeleton, can prevent children rachitis, adult's osteoporosis and osteomalacia；In Sparassia crispa (Wulf.) Fr., potassium content is the highest, and sodium content is relatively low, and hyperkalemia hyponatremia has the effect of diuresis, highly beneficial to hypertension；Containing substantial amounts of antioxidant in Sparassia crispa (Wulf.) Fr., such as superoxide dismutase, can the effective free radical in purged body, prevent the active oxygen infringement to body, have the effect of antioxidation, defying age.
Oral liquid has the advantages such as taking dose is little, it is very fast to absorb, steady quality, easy to carry and use, easy preservation, is especially suitable for industrialized production.Therefore how tablet, granule, pill, decoction, herb mixture, injection etc. are changed system into oral liquid in recent years, make and pharmaceutical preparation develops one of dosage form faster.The most currently also there is the oral liquid of a lot of hypertension and hyperlipemia, health care oral liquid of Fructus Viticis of a kind of hypertension and hyperlipemia and preparation method thereof as disclosed in the patent No. 201510409243.5, do not find the oral liquid with Sparassia crispa (Wulf.) Fr. as formula material through retrieval.
Summary of the invention
It is an object of the invention to, for prior art, it is provided that Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing and preparation method thereof.
For achieving the above object, the present invention takes techniques below scheme: the Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing is made up of the following raw material of mass parts: Sparassia crispa (Wulf.) Fr. 30～40 parts, Spica Prunellae 5～10 parts, Flos Chrysanthemi 5～8 parts, Fructus Crataegi 3～5 parts, Stigma Maydis 3～7 parts, Ramulus Uncariae Cum Uncis 5～10 parts, Herba Apocyni veneti 5～7 parts, Eupolyphaga Seu Steleophaga 3～5 parts, Herba Artemisiae Scopariae 3～7 parts, Thallus Laminariae (Thallus Eckloniae) 4～7 parts, refined honey 5～10 parts, correctives 5～10 parts.
Wherein, described correctives is the one of glucose, white sugar, brown sugar.
Wherein, its preparation method is:
(1) pretreatment of raw material: Sparassia crispa (Wulf.) Fr., Spica Prunellae, Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Ramulus Uncariae Cum Uncis, Herba Apocyni veneti, Eupolyphaga Seu Steleophaga, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae) are respectively placed at 110～120 DEG C and are dried 1～2h, more each medical material carries out superfine powder and is broken into the powder of 8～10um；
(2) preparation of aqueous extract: the water of 5～8 times of mass parts will be added after Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Stigma Maydis, Herba Apocyni veneti, Fructus Crataegi mixing, after dipping 5～6h, heated and boiled 1～2h, first-time filtrate is obtained with microfilter filtration, the most respectively filtering residue be impregnated in the water of 3～5 times of mass parts, boil 2h, filter to get filtrate with microfilter, mix to obtain Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Herba Apocyni veneti mixing water extract with an extracting solution；
(3) preparation of alcohol extract: Spica Prunellae, Ramulus Uncariae Cum Uncis, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae), eupolyphage sece steleophaga Trionyx sinensis Wiegmann are soaked in respectively 5～6 times of mass parts 85% ethanol solution 2h, heating and refluxing extraction 2 times, each 1～2h, stand after extracting solution is merged, again filtering residue is added in the water of 3～5 times of mass parts, heating and refluxing extraction 1h, extracting solution and ethanol extract are mixed, obtains alcohol extract；
(4) concentration, dispensing: at 50～60 DEG C after step (2) and step (3) are mixed, the relative density being evaporated to concentrated solution under vacuum 0.8kpa is 1.02～1.04, after cold preservation 48h, filter press filters to obtain clear paste, clear paste is centrifuged again, filters with Hollow Fiber Ultrafiltration equipment and be placed in material-compound tank, add refined honey and correctives, stir static 48～50h, then carry out fill；
(5) sterilizing: by sterilizing 30～40min at temperature is 110～120 DEG C of the oral liquid after tinning.
Wherein, in described step (3), reflux, extract, temperature is 60～70 DEG C.
Further, Sparassia crispa (Wulf.) Fr. contains substantial amounts of protein, carbohydrate, multivitamin, several amino acids and dietary fiber and ash, mineral etc..Wherein, Sparassia crispa (Wulf.) Fr. contains substantial amounts of beta glucan, and beta glucan is a kind of bioactive substance, has immunomodulating, antitumor, antiinflammatory, antiviral, antioxidation, radioprotective, blood sugar lowering, blood fat reducing, protects the liver, improves the several functions such as hemopoietic function.
Further, Herba Artemisiae Scopariae bitter in the mouth, pungent, cold nature, return spleen, stomach, liver, gallbladder meridian, the tonkabean in Herba Artemisiae Scopariae have Lipid-lowering activities, can lower serum cholesterol, makes aortosclerosis alleviate, has liver function protecting, has the effects such as blood fat reducing, blood pressure lowering, coronary dilating.
Further, Eupolyphaga Seu Steleophaga, salty in the mouth, cold in nature, there is removing blood stasis, effect of reunion of fractured tendons and bones, its alkaloid contained has effect of blood pressure lowering blood fat reducing.
Further, Flos Chrysanthemi acrid in the mouth, sweetness and bitterness, cold nature, return lung, Liver Channel, have effect of suppressing the hyperactive liver improving eyesight.
Further, Fructus Crataegi is sour, sweet, tepor, return spleen, stomach, Liver Channel, can promoting digestion, circulation of qi promoting dissipating blood stasis.
Further, Spica Prunellae bitter in the mouth is pungent, cold in nature, returns liver, gallbladder meridian, can clearing away liver-fire Disperse hepatic depression.
Further, Herba Apocyni veneti property of medicine sweet, bitter, cold.Return Liver Channel.Suppressing liver-YANG, clearing away heat and promoting diuresis.Can treat and have a dizzy spell and edema, dysuria, Herba Apocyni veneti has the effects such as blood pressure lowering heart tonifying, blood fat reducing, diuresis, radioprotective, slow down aging.
Further, Ramulus Uncariae Cum Uncis is used as medicine with dry stem and branch with belt hook.There is calmness, blood pressure lowering, heat clearing away suppressing the hyperactive liver, the function of dispelling wind and relieving convulsion, be used for dizziness of having a headache, the diseases such as dysphoric cold, infantile convulsion are twitched, pre-eclampsia, hypertension.
Further, Stigma Maydis has containing effective ingredients such as abundant flavonoid, polysaccharide, alcohols, saponins, alkaloids, organic acid, alkanes, aminoacid, has antibacterial, effect of antitumor, antioxidation, lowering blood pressure and blood fat, blood sugar lowering, hepatic cholagogic, diuresis and expelling stone.
Further, Thallus Laminariae (Thallus Eckloniae) nature and flavor are trembled with fear, salty, there are hard masses softening and resolving, detumescencing diuresis, the merit of relaxing the bowels with lubricant drugs expectorant,, bronchitis, pulmonary tuberculosis swollen for goiter, lymphonodi cervicales, cough and senile cataract etc. clinically, also trying out in treatment cancer, and the sodium alginate in Thallus Laminariae (Thallus Eckloniae) has hypotensive effect, Thallus Laminariae (Thallus Eckloniae) starch has the effect of blood fat reducing.
The invention has the beneficial effects as follows:
1, with Sparassia crispa (Wulf.) Fr. as main component in the present invention, compound with Ramulus Uncariae Cum Uncis, Roman cloth, Flos Chrysanthemi, Spica Prunellae, Fructus Crataegi, Thallus Laminariae (Thallus Eckloniae), Herba Artemisiae Scopariae, Eupolyphaga Seu Steleophaga, Stigma Maydis, there is the effects such as Liver-Clearing Powder fire, detumescencing diuresis, hepatic cholagogic, lowering blood pressure and blood fat.
2, the present invention also has the health-care effects such as foster antiinflammatory, antitumor, anticancer, antioxidation, anti-aging, enhancing immunity.
Detailed description of the invention
Below in conjunction with specific embodiment, to further instruction of the present invention.
Embodiment 1
The Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing is made up of the following raw material of mass parts: Sparassia crispa (Wulf.) Fr. 30 parts, Spica Prunellae 5 parts, Flos Chrysanthemi 5 parts, Fructus Crataegi 3 parts, Stigma Maydis 3 parts, Ramulus Uncariae Cum Uncis 5 parts, Herba Apocyni veneti 5 parts, Eupolyphaga Seu Steleophaga 3 parts, Herba Artemisiae Scopariae 3 parts, Thallus Laminariae (Thallus Eckloniae) 4 parts, refined honey 5 parts, correctives 5 parts, wherein, sweeting agent is glucose.
Its preparation method is:
(1) pretreatment of raw material: Sparassia crispa (Wulf.) Fr., Spica Prunellae, Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Ramulus Uncariae Cum Uncis, Herba Apocyni veneti, Eupolyphaga Seu Steleophaga, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae) are respectively placed at 110 DEG C and are dried 1h, more each medical material carries out superfine powder and is broken into the powder of 8um；
(2) preparation of aqueous extract: the water of 5 times of mass parts will be added after Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Stigma Maydis, Herba Apocyni veneti, Fructus Crataegi mixing, after dipping 5h, heated and boiled 1h, first-time filtrate is obtained with microfilter filtration, the most respectively filtering residue be impregnated in the water of 3 times of mass parts, boil 2h, filter to get filtrate with microfilter, mix to obtain Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Herba Apocyni veneti mixing water extract with an extracting solution；
(3) preparation of alcohol extract: Spica Prunellae, Ramulus Uncariae Cum Uncis, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae), eupolyphage sece steleophaga Trionyx sinensis Wiegmann are soaked in respectively 5 times of mass parts 85% ethanol solution 2h, it is heated to 60 DEG C of reflux, extract, 2 times, each 1h, stand after extracting solution is merged, again filtering residue is added in the water of 3 times of mass parts, it is heated to 60 DEG C of reflux, extract, 1h, extracting solution and ethanol extract are mixed, obtains alcohol extract；
(4) concentration, dispensing: at 50 DEG C after step (2) and step (3) are mixed, the relative density being evaporated to concentrated solution under vacuum 0.8kpa is 1.02, after cold preservation 48h, filter press filters to obtain clear paste, clear paste is centrifuged again, filters with Hollow Fiber Ultrafiltration equipment and be placed in material-compound tank, add refined honey and correctives, stir static 48h, then carries out fill；
(5) sterilizing: by the sterilizing 30min at temperature is 110 DEG C of the oral liquid after tinning.
Embodiment 2
The Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing is made up of the following raw material of mass parts: Sparassia crispa (Wulf.) Fr. 40 parts, Spica Prunellae 10 parts, Flos Chrysanthemi 8 parts, Fructus Crataegi 5 parts, Stigma Maydis 7 parts, Ramulus Uncariae Cum Uncis 10 parts, Herba Apocyni veneti 7 parts, Eupolyphaga Seu Steleophaga 5 parts, Herba Artemisiae Scopariae 7 parts, Thallus Laminariae (Thallus Eckloniae) 7 parts, refined honey 10 parts, correctives 10 parts, wherein, sweeting agent is white sugar.
Its preparation method is:
(1) pretreatment of raw material: Sparassia crispa (Wulf.) Fr., Spica Prunellae, Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Ramulus Uncariae Cum Uncis, Herba Apocyni veneti, Eupolyphaga Seu Steleophaga, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae) are respectively placed at 120 DEG C and are dried 2h, more each medical material carries out superfine powder and is broken into the powder of 10um；
(2) preparation of aqueous extract: the water of 8 times of mass parts will be added after Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Stigma Maydis, Herba Apocyni veneti, Fructus Crataegi mixing, after dipping 6h, heated and boiled 2h, first-time filtrate is obtained with microfilter filtration, the most respectively filtering residue be impregnated in the water of 5 times of mass parts, boil 2h, filter to get filtrate with microfilter, mix to obtain Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Herba Apocyni veneti mixing water extract with an extracting solution；
(3) preparation of alcohol extract: Spica Prunellae, Ramulus Uncariae Cum Uncis, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae), eupolyphage sece steleophaga Trionyx sinensis Wiegmann are soaked in respectively 6 times of mass parts 85% ethanol solution 2h, it is heated to 70 DEG C of reflux, extract, 2 times, each 2h, stand after extracting solution is merged, again filtering residue is added in the water of 5 times of mass parts, it is heated to 70 DEG C of reflux, extract, 1h, extracting solution and ethanol extract are mixed, obtains alcohol extract；
(4) concentration, dispensing: at 60 DEG C after step (2) and step (3) are mixed, the relative density being evaporated to concentrated solution under vacuum 0.8kpa is 1.04, after cold preservation 48h, filter press filters to obtain clear paste, clear paste is centrifuged again, filters with Hollow Fiber Ultrafiltration equipment and be placed in material-compound tank, add refined honey and correctives, stir static 50h, then carries out fill；
(5) sterilizing: by the sterilizing 40min at temperature is 120 DEG C of the oral liquid after tinning.
Embodiment 3
The Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing is made up of the following raw material of mass parts: Sparassia crispa (Wulf.) Fr. 35 parts, Spica Prunellae 6 parts, Flos Chrysanthemi 7 parts, Fructus Crataegi 4 parts, Stigma Maydis 5 parts, Ramulus Uncariae Cum Uncis 8 parts, Herba Apocyni veneti 6 parts, Eupolyphaga Seu Steleophaga 4 parts, Herba Artemisiae Scopariae 6 parts, Thallus Laminariae (Thallus Eckloniae) 5 parts, refined honey 8 parts, correctives 8 parts, wherein, sweeting agent is brown sugar.
Its preparation method is:
(1) pretreatment of raw material: Sparassia crispa (Wulf.) Fr., Spica Prunellae, Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Ramulus Uncariae Cum Uncis, Herba Apocyni veneti, Eupolyphaga Seu Steleophaga, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae) are respectively placed at 115 DEG C and are dried 2h, more each medical material carries out superfine powder and is broken into the powder of 9um；
(2) preparation of aqueous extract: the water of 7 times of mass parts will be added after Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Stigma Maydis, Herba Apocyni veneti, Fructus Crataegi mixing, after dipping 5h, heated and boiled 2h, first-time filtrate is obtained with microfilter filtration, the most respectively filtering residue be impregnated in the water of 4 times of mass parts, boil 2h, filter to get filtrate with microfilter, mix to obtain Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Herba Apocyni veneti mixing water extract with an extracting solution；
(3) preparation of alcohol extract: Spica Prunellae, Ramulus Uncariae Cum Uncis, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae), eupolyphage sece steleophaga Trionyx sinensis Wiegmann are soaked in respectively 6 times of mass parts 85% ethanol solution 2h, it is heated to 65 DEG C of reflux, extract, 2 times, each 2h, stand after extracting solution is merged, again filtering residue is added in the water of 4 times of mass parts, it is heated to 65 DEG C of reflux, extract, 1h, extracting solution and ethanol extract are mixed, obtains alcohol extract；
(4) concentration, dispensing: at 55 DEG C after step (2) and step (3) are mixed, the relative density being evaporated to concentrated solution under vacuum 0.8kpa is 1.03, after cold preservation 48h, filter press filters to obtain clear paste, clear paste is centrifuged again, filters with Hollow Fiber Ultrafiltration equipment and be placed in material-compound tank, add refined honey and correctives, stir static 48h, then carries out fill；
(5) sterilizing: by the sterilizing 35min at temperature is 115 DEG C of the oral liquid after tinning.
Claims (4)
1. the Sparassia crispa (Wulf.) Fr. health care oral liquid of a blood fat-reducing blood pressure-decreasing, it is characterized in that, it is made up of the following raw material of mass parts: Sparassia crispa (Wulf.) Fr. 30～40 parts, Spica Prunellae 5～10 parts, Flos Chrysanthemi 5～8 parts, Fructus Crataegi 3～5 parts, Stigma Maydis 3～7 parts, Ramulus Uncariae Cum Uncis 5～10 parts, Herba Apocyni veneti 5～7 parts, Eupolyphaga Seu Steleophaga 3～5 parts, Herba Artemisiae Scopariae 3～7 parts, Thallus Laminariae (Thallus Eckloniae) 4～7 parts, refined honey 5～10 parts, correctives 5～10 parts.
The Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing the most according to claim 1, it is characterised in that described correctives is the one of glucose, white sugar, brown sugar.
The preparation method of the Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of blood fat-reducing blood pressure-decreasing the most according to claim 1 and 2, it is characterised in that comprise the following steps:
(1) pretreatment of raw material: Sparassia crispa (Wulf.) Fr., Spica Prunellae, Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Ramulus Uncariae Cum Uncis, Herba Apocyni veneti, Eupolyphaga Seu Steleophaga, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae) are respectively placed at 110～120 DEG C and are dried 1～2h, more each medical material carries out superfine powder and is broken into the powder of 8～10um；
(2) preparation of aqueous extract: the water of 5～8 times of mass parts will be added after Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Stigma Maydis, Herba Apocyni veneti, Fructus Crataegi mixing, after dipping 5～6h, heated and boiled 1～2h, first-time filtrate is obtained with microfilter filtration, the most respectively filtering residue be impregnated in the water of 3～5 times of mass parts, boil 2h, filter to get filtrate with microfilter, mix to obtain Sparassia crispa (Wulf.) Fr., Flos Chrysanthemi, Fructus Crataegi, Stigma Maydis, Herba Apocyni veneti mixing water extract with an extracting solution；
(3) preparation of alcohol extract: Spica Prunellae, Ramulus Uncariae Cum Uncis, Herba Artemisiae Scopariae, Thallus Laminariae (Thallus Eckloniae), eupolyphage sece steleophaga Trionyx sinensis Wiegmann are soaked in respectively 5～6 times of mass parts 85% ethanol solution 2h, heating and refluxing extraction 2 times, each 1～2h, stand after extracting solution is merged, again filtering residue is added in the water of 3～5 times of mass parts, heating and refluxing extraction 1h, extracting solution and ethanol extract are mixed, obtains alcohol extract；
(4) concentration, dispensing: at 50～60 DEG C after step (2) and step (3) are mixed, the relative density being evaporated to concentrated solution under vacuum 0.8kpa is 1.02～1.04, after cold preservation 48h, filter press filters to obtain clear paste, clear paste is centrifuged again, filters with Hollow Fiber Ultrafiltration equipment and be placed in material-compound tank, add refined honey and correctives, stir static 48～50h, then carry out fill；
(5) sterilizing: by sterilizing 30～40min at temperature is 110～120 DEG C of the oral liquid after tinning.
The preparation method of the Sparassia crispa (Wulf.) Fr. health care oral liquid of a kind of hypertension and hyperlipemia the most according to claim 3, it is characterised in that in described step (3), reflux, extract, temperature is 60～70 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610176059.5A CN105816699A (en) | 2016-03-25 | 2016-03-25 | Sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610176059.5A CN105816699A (en) | 2016-03-25 | 2016-03-25 | Sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105816699A true CN105816699A (en) | 2016-08-03 |
Family
ID=56524731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610176059.5A Pending CN105816699A (en) | 2016-03-25 | 2016-03-25 | Sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105816699A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075062A (en) * | 2016-08-10 | 2016-11-09 | 翔天农业开发集团股份有限公司 | A kind of antilipemic healthy oral liquid and preparation method thereof |
| CN106389929A (en) * | 2016-11-30 | 2017-02-15 | 广西大学 | Sparassiscrispa oral liquid and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857584A (en) * | 2006-03-14 | 2006-11-08 | 王信锁 | Hypertension treating Chinese medicine preparation |
| CN101305826A (en) * | 2007-05-17 | 2008-11-19 | 沙纯荣 | Sparassis crsipa beverage |
| CN105343593A (en) * | 2015-11-09 | 2016-02-24 | 青岛安倍康生物医药技术有限公司 | Spica prunellae health oral liquid capable of decreasing blood pressure and blood lipid as well as preparation method of spica prunellae health oral liquid |
-
2016
- 2016-03-25 CN CN201610176059.5A patent/CN105816699A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857584A (en) * | 2006-03-14 | 2006-11-08 | 王信锁 | Hypertension treating Chinese medicine preparation |
| CN101305826A (en) * | 2007-05-17 | 2008-11-19 | 沙纯荣 | Sparassis crsipa beverage |
| CN105343593A (en) * | 2015-11-09 | 2016-02-24 | 青岛安倍康生物医药技术有限公司 | Spica prunellae health oral liquid capable of decreasing blood pressure and blood lipid as well as preparation method of spica prunellae health oral liquid |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075062A (en) * | 2016-08-10 | 2016-11-09 | 翔天农业开发集团股份有限公司 | A kind of antilipemic healthy oral liquid and preparation method thereof |
| CN106389929A (en) * | 2016-11-30 | 2017-02-15 | 广西大学 | Sparassiscrispa oral liquid and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103637319B (en) | Pear soup beverage and preparation method for same | |
| CN102228180B (en) | Betelnut buccal tablet and preparation method thereof | |
| CN104957602B (en) | Sugarcane active component composition and functional health-care food and preparation method thereof | |
| CN103749816B (en) | Lotus leaf bitter gourd lipid-lowering health-care tea and preparation method thereof | |
| CN103961561B (en) | A kind of Herba Dendrobii is relieved summer heat Halth-care composition and preparation method thereof | |
| CN103609992B (en) | Preparation method of Korean red ginseng cream | |
| CN105695258A (en) | Female health wine containing lychee seed saponin | |
| KR20130056780A (en) | Cosmetic composition comprising soapnut | |
| CN104207241B (en) | A kind of integration of drinking and medicinal herbs composite health care beverage and preparation method thereof | |
| CN108175785A (en) | Golden flower composite health beverage and preparation method thereof | |
| CN110839725A (en) | Clinacanthus nutans functional tea beverage formula and preparation method | |
| CN107333926A (en) | A kind of Seabuckthorn healthcare tea and its preparation technology | |
| CN110075266A (en) | One breeding kidney reinforces the kidney the formula to fill blood and preparation method | |
| CN105907458A (en) | Health-caring sesame oil suitable for people having hypertension, hyperglycemia and hyperlipidemia and preparation method of same | |
| CN103404640B (en) | Liver and stomach nourishing tea and preparation method thereof | |
| CN105533598A (en) | Health-care honey and preparation method thereof | |
| CN105816699A (en) | Sparassis crispa healthcare oral liquid with lipid and pressure reducing effects and preparation method thereof | |
| CN105077489A (en) | Maca functional beverage and making method thereof | |
| CN108684992A (en) | A kind of alcohol-decomposing beverage of plant formula and preparation method thereof of energy Quick sobering | |
| KR101381277B1 (en) | The wild rice gel containing ginseng | |
| KR20100035961A (en) | Composition of gongjindan comprising nono powder of jinseung | |
| CN108969658A (en) | A kind of preparation method of hundred hay-scenteds mist | |
| CN108813001A (en) | A kind of function tea for preventing and treating hypertension | |
| CN106728866A (en) | A kind of health protection tea for treating physically weak cough and preparation method thereof | |
| KR101397189B1 (en) | extraction beverage and manufacturing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160803 |