CN103520685A - Production method of pawpaw anti-alcohol syrup - Google Patents
Production method of pawpaw anti-alcohol syrup Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a pawpaw anti-alcohol syrup pharmaceutical composition taking pawpaw as a main raw material and a preparation method thereof. The pawpaw anti-alcohol syrup is prepared from the following raw materials: the pawpaw, radix puerariae, poria cocos, cortex albiziae, spica prunellae, cassia twig, fructus hordei germinates, radix aconiti preparata, fructus gardeniae, peach kernel, liquorice, frankincense, fructus crataegi, rhizoma zingiberis, folium perillae, glossy privet fruit, hippophae rhamnoides, fructus lycii and red date. The medicinal materials are combined to bring out the best in each other, the metabolism of alcohol in human body can be accelerated, the excretion of alcohol can be increased, and the resistant ability of the human body against alcohol can be enhanced; by taking the pawpaw anti-alcohol syrup after the user gets drunk, the discomfort symptoms such as headache, dizziness and nausea caused by drunkenness can be improved and treated so as to realize an anti-alcohol effect. The curative effect is remarkable and reliable, and the application prospect is broad.
Description
Technical field
The invention belongs to Chinese medicine technical field, concrete, relate to a kind of production method of Fructus Chaenomelis solution JIULU
Background technology
Over the past thousands of years, wine is also present in us at one's side as a kind of medium of interchange as a kind of beverage simultaneously, drink on a small quantity existing certain effect of invigorating blood circulation, there is again certain excitation, can increase the atmosphere of the social lives such as red-letter day, party, but excessive consumption of alcohol, the drunk harm to human body are very serious.Acute heavy drinking can cause nausea, vomiting, absent minded, fine movement ability is impaired, emotional instability, can cause that lethargy, stupor, breathing, circulatory function die of exhaustion to die when serious.The many pathological changes of system such as can causing digestion, nerve, circulation of drinking for a long time.Ethanol has minute quantity directly through urine, antiperspirant or lung, to discharge in vivo, and most ethanol, mainly at liver metabolism, is converted into acetaldehyde through ethanol dehydrogenase by ethanol, acetaldehyde, and acetaldehyde is poisonous to human body, then be oxidized to acetic acid through liver aldehyde dehydrogenase, finally become water and carbon dioxide excretes.Long-term heavy drinking, can cause alcoholic liver disease, alcoholic encephalopathy, brain atrophy, alcoholic dementia, Alcoholic osteopathia, osteoporosis and femur head necrosis, also can cause alcoholic cardiomyopathy, the prevalence of coronary heart disease and case fatality rate be increased, impotence, pregnancy period infant development defect, the contaminated wine being brewed can be carcinogenic.
Current nearly 300,000,000 people of the long-term alcohol user of China, 20% disease that inpatient takes a disease is relevant with excessive drinking.Alcohol dependence and relevant issues thereof become the third-largest public health problem that is only second to cardiovascular and cerebrovascular disease, tumor.The health that alcohol abuse causes and social danger and economic loss have caused the extensive attention of international community.
The classification of existing market antialcoholic drug and effect: 1, chemical drugs: be mostly the compositions such as analeptic, vitamin and aminoacid, play the effect that promotes ethanol decomposition and relieving alcoholic intoxication, the internal organs that ethanol is caused injury and chronic poisoning have little effect.2, enzyme preparation: containing the antialcoholism capsule of aldehyde dehydrogenase and Chinese medicine, can decompose rapidly acetaldehyde and absorption ethanol, but expensive.3, Chinese medicine preparation: Chinese medicinal alcoholism-relieving has long history, adopts Overall View determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and acute and chronic alcoholism is all had to therapeutical effect.
There is abundant resources of medicinal plant in China, and Ancient Times in China has many good recipes of relieving the effect of alcohol all through the ages, and the various diseases that cause drinking have corresponding formula.Contained according to ancient books, prescription or method for the treatment of are varied, the not complete statistics to Holy Benevolent Prescriptions, Effective Formulas Tested by Physicians for Generations, " Prescriptions for Universal Relief " and " Yifangleiju " only, size relieve the effect of alcohol and alleviating alcohol addiction side's medicine approximately more than 150 is planted, the prescription that wherein relieves the effect of alcohol accounts for 90%, and alleviating alcohol addiction prescription accounts for 10%.Current China has some scholars to study as the ability of relieving the effect of alcohol of the proved recipes that relieve the effect of alcohol such as Flos puerariae lobatae solution sobering soup, winebibber's pleasure, dry clock wine, Shigao Tang and WUZIYANZONG WAN quintessence of Chinese culture ancient prescription wherein, and has people to develop sober-up oral liquid, drunkenness dispelling tea and the functional preparation that relieves the effect of alcohol.
Summary of the invention
The present invention with reference to motherland's medical science to the understanding of relieving mechanism and experience, consult existing reasonable formula, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to Chinese Pharmacopoeia and pharmacology compatibility, push away Chen Zhixin and gain to some extent, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how for main pathogenesis medication, to take into account less important pathogenesis simultaneously, taking into account the treatment of general character and individual character, thereby at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.
The object of the invention is can to relieve the effect of alcohol for after the people of insobriety is drunk in right amount, diuresis, protect the liver and a kind of functional solution JIULU with the effect of fast reducing blood-alcohol concentration of providing.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
A compositions with antialcoholism function, is characterized in that being obtained by the raw material preparation of following weight proportioning:
50 parts of Fructus Chaenomeliss, 25 parts of Radix Puerariaes, 20 parts, Poria, 20 parts of Cortex Albiziaes,
20 parts of Spica Prunellaes, 18 parts of Ramulus Cinnamomi, 18 parts, Fructus Hordei Germinatus, 18 parts of Radix Aconiti Preparatas,
15 parts of Fructus Gardeniaes, 15 parts, Semen Persicae, 15 parts, Radix Glycyrrhizae, 12 parts of Olibanums,
10 parts of Fructus Crataegis, 10 parts of Rhizoma Zingiberiss, 10 parts of Folium Perillaes, 8 parts of Fructus Ligustri Lucidi,
8 parts of Fructus Hippophaes, 5 parts of Fructus Lycii, 5 parts of Fructus Jujubaes.
Pharmaceutical composition its preparation method of the present invention is: crude drug (proportioning unit: gram) concrete operations of getting above-mentioned parts by weight are as follows:
1) take each crude drug, standby;
2) get Fructus Chaenomelis, Radix Puerariae, Poria, Cortex Albiziae, Spica Prunellae, Ramulus Cinnamomi, Rhizoma Zingiberis, Folium Perillae mix homogeneously, the water intense fire that adds 3 times of weight boils, and then slow fire boiling is 1 hour, filters and collects filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boils, and then slow fire boiling is 30 minutes, filters and collects filtrate; Merge above-mentioned twice filtrate and obtain liquid A;
3) get all the other compositions (being Fructus Hordei Germinatus, Radix Aconiti Preparata, Fructus Gardeniae, Semen Persicae, Radix Glycyrrhizae, Olibanum, Fructus Crataegi, Fructus Ligustri Lucidi, Fructus Hippophae, Fructus Lycii, Fructus Jujubae) and add 70% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hours, merge extractive liquid,, filter, obtain liquid B;
4) by liquid A, liquid B mixing and stirring and get final product.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, bring out the best in each other, monarch is respectively executed its effect, and the drinking amount that general reaction is taken after this product can double and have no adverse reaction.This product is taken half an hour before drinking, and can reduce the absorption of human body to ethanol, accelerates ethanol metabolism in vivo simultaneously, increases the excretion of ethanol, strengthens the tolerance of human body to ethanol; After drunk, take and can improve with treatment because of the drunk headache causing, dizziness, the malaise symptoms such as feel sick, play antialcoholism action.Evident in efficacy reliable, have a extensive future.
The specific embodiment
Embodiment 1
A compositions with antialcoholism function, is characterized in that being obtained by the raw material preparation of following weight proportioning:
50 parts of Fructus Chaenomeliss, 25 parts of Radix Puerariaes, 20 parts, Poria, 20 parts of Cortex Albiziaes,
20 parts of Spica Prunellaes, 18 parts of Ramulus Cinnamomi, 18 parts, Fructus Hordei Germinatus, 18 parts of Radix Aconiti Preparatas,
15 parts of Fructus Gardeniaes, 15 parts, Semen Persicae, 15 parts, Radix Glycyrrhizae, 12 parts of Olibanums,
10 parts of Fructus Crataegis, 10 parts of Rhizoma Zingiberiss, 10 parts of Folium Perillaes, 8 parts of Fructus Ligustri Lucidi,
8 parts of Fructus Hippophaes, 5 parts of Fructus Lycii, 5 parts of Fructus Jujubaes.
Pharmaceutical composition its preparation method of the present invention is: crude drug (proportioning unit: gram) concrete operations of getting above-mentioned parts by weight are as follows:
1) take each crude drug, standby;
2) get Fructus Chaenomelis, Radix Puerariae, Poria, Cortex Albiziae, Spica Prunellae, Ramulus Cinnamomi, Rhizoma Zingiberis, Folium Perillae mix homogeneously, the water intense fire that adds 3 times of weight boils, and then slow fire boiling is 1 hour, filters and collects filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boils, and then slow fire boiling is 30 minutes, filters and collects filtrate; Merge above-mentioned twice filtrate and obtain liquid A;
3) get all the other compositions (being Fructus Hordei Germinatus, Radix Aconiti Preparata, Fructus Gardeniae, Semen Persicae, Radix Glycyrrhizae, Olibanum, Fructus Crataegi, Fructus Ligustri Lucidi, Fructus Hippophae, Fructus Lycii, Fructus Jujubae) and add 70% soak with ethanol 1 hour, extract twice, each 1.5 hours, merge extractive liquid,, filter and collect filtrate, be liquid B;
4) by liquid A, liquid B mixing and stirring and get final product, each serving using 150ml.
Embodiment 2
The drunk prevention experiment of one mice
Experiment material: get the solution JIULU that the embodiment of the present invention 1 makes, it is standby that commercially available strong, colourless liquor distilled from sorghum is made into the aqueous solution of spirituosity 40%.
Experimental technique: get 40 of Kunming kind white mice, male and female dual-purpose, body weight 18-20g, be divided at random 2 groups, every group 20, difference setting model group, the embodiment of the present invention 1 medicine group, each organize every day gavage to wine 0.4mL/ only, model group every day to wine before 30min, gavage feedwater 0.1mL, administration group every day to wine before 30min, equal gastric infusion 0.1mL, carry out continuously 30, and respectively the 2nd, 5, 10, 15, in the time of 20 days, mice is carried out to righting reflex experiment, observation to ethanol after in 1 hour mice there is the number of elements of righting reflex loss, righting reflex loss can think that animal is drunk, 5 observed results of accumulative total (amounting to 100 times), calculate its drunk number of times.Experimental result shows, administration group is compared with model group, and drunk number of times obviously reduces, and shows that it has the effect of good pre-preventing drunkenness, in Table 1.
The drunk prevention experiment of mice table 1
| Group | Number of cases | Drunk number of times |
| Model group | 20 | 77 |
| Administration group | 20 | 9 |
Two, the mice ability of relieving the effect of alcohol is tested
Get 40 of Kunming mouses, male and female dual-purpose, at laboratory rearing 1d.Then fasting 5h, is divided into 1 group of model group (blank group), the embodiment of the present invention at random after the labelling of weighing.First gavage, to medicated wine amount 0.25ml/20g, is given administration immediately after drinking, and blank group gives distilled water.Take righting reflex loss as sleep index, calculate tolerance time (time from ethanol gavage to righting reflex loss) and liquor-saturated sleeping the time (from righting reflex loss to the time of recovering), result is as follows, in Table 2:
Table 2
| Group | Number of cases | Not liquor-saturated (only) | Liquor-saturated sleeping (only) | Tolerance time |
| Model group | 20 | 0 | 20 | 2.3±0.5 |
| Administration group | 20 | 13 | 7 | 20.7±1.3 |
Therefore solution JIULU of the present invention can obviously strengthen the tolerance time of mice, the effect of relieving the effect of alcohol is remarkable.
Embodiment 3
Clinical data
Case selection: select easy headache person 53 people in the crowd that drinks for a long time, at 23-55 years old ages, be all male.
Therapeutic Method: before and after drinking, respectively take the solution JIULU of embodiment 1 preparation half an hour, drinking amount therewith before during headache drinking amount suitable.
Curative effect determinate standard:
Effective: no headache symptom.
Effective: headache degree alleviates, the headache time shortens.
Invalid: headache degree does not change.
Result: take embodiment 1 preparation and separate after JIULU, 37 people that have of the transference cure of having a headache, separately have 13 people to react headache degree and alleviate, and the headache time shortens, and 3 people's headache degree do not change, and the total effective rate that calculates thus solution JIULU of the present invention is: 94.3%.
Embodiment 4
Model case
Zhao, Zheng drink together, and everyone drinks and is greater than 500ml, all occurs acute alcoholism, headache, dizziness, feels sick, drunken man gait, mind fuzzy about half an hour, start to drink the solution JIULU of the embodiment of the present invention 1 preparation, drink 150ml per half an hour, successively clear-headed after 1 hour, slight headache still, after 2 hours, symptom all disappears.
Zheng, job specification determines long-term heavy drinking, occurs ictally forgeing after 2 years, touches liver 1cm under costal margin.Examine as chronic alcoholism, adhere to every day twice, each serving 150ml of the present invention, after 1 month, symptom and sign disappears, and adheres to again taking 1 month, gets well.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, can also have many distortion.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention, all should think protection scope of the present invention.
Claims (3)
1. a Fructus Chaenomelis solution JIULU with antialcoholism function, is characterized in that being obtained by the raw material preparation of following weight proportioning:
50 parts of Fructus Chaenomeliss, 25 parts of Radix Puerariaes, 20 parts, Poria, 20 parts of Cortex Albiziaes,
20 parts of Spica Prunellaes, 18 parts of Ramulus Cinnamomi, 18 parts, Fructus Hordei Germinatus, 18 parts of Radix Aconiti Preparatas,
15 parts of Fructus Gardeniaes, 15 parts, Semen Persicae, 15 parts, Radix Glycyrrhizae, 12 parts of Olibanums,
10 parts of Fructus Crataegis, 10 parts of Rhizoma Zingiberiss, 10 parts of Folium Perillaes, 8 parts of Fructus Ligustri Lucidi,
8 parts of Fructus Hippophaes, 5 parts of Fructus Lycii, 5 parts of Fructus Jujubaes.
2. the preparation method of Fructus Chaenomelis solution JIULU described in claim 1, is characterized in that concrete operation step is as follows:
1) take each crude drug, standby;
2) get Fructus Chaenomelis, Radix Puerariae, Poria, Cortex Albiziae, Spica Prunellae, Ramulus Cinnamomi, Rhizoma Zingiberis, Folium Perillae mix homogeneously, the water intense fire that adds 3 times of weight boils, and then slow fire boiling is 1 hour, filters and collects filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boils, and then slow fire boiling is 30 minutes, filters and collects filtrate; Merge above-mentioned twice filtrate and obtain liquid A;
3) get all the other compositions (being Fructus Hordei Germinatus, Radix Aconiti Preparata, Fructus Gardeniae, Semen Persicae, Radix Glycyrrhizae, Olibanum, Fructus Crataegi, Fructus Ligustri Lucidi, Fructus Hippophae, Fructus Lycii, Fructus Jujubae) and add 70% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid,, filter, obtain liquid B;
4) by liquid A, liquid B mixing and stirring and get final product.
3. the purposes that the pharmaceutical composition of claim 1-2 is relieving the effect of alcohol.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103932173A (en) * | 2014-03-25 | 2014-07-23 | 姜利 | Composition for dispelling alcohol effect and protecting liver |
| CN104127644A (en) * | 2014-07-21 | 2014-11-05 | 任朝勋 | Sober solution |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028500A (en) * | 2007-03-21 | 2007-09-05 | 孙喜灵 | Two-purpose food with appetising and sobering-up functions and its production |
| CN102018942A (en) * | 2009-09-09 | 2011-04-20 | 何波运 | Smoking cessation sober-up tea |
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2013
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028500A (en) * | 2007-03-21 | 2007-09-05 | 孙喜灵 | Two-purpose food with appetising and sobering-up functions and its production |
| CN102018942A (en) * | 2009-09-09 | 2011-04-20 | 何波运 | Smoking cessation sober-up tea |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103932173A (en) * | 2014-03-25 | 2014-07-23 | 姜利 | Composition for dispelling alcohol effect and protecting liver |
| CN103932173B (en) * | 2014-03-25 | 2016-01-13 | 张海燕 | A kind of composition of relieving alcoholism and protecting liver |
| CN104127644A (en) * | 2014-07-21 | 2014-11-05 | 任朝勋 | Sober solution |
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| CN103520685B (en) | 2015-11-25 |
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