CN102406690B - Traditional Chinese medicine gynostemma pentaphylla buccal tablet - Google Patents
Traditional Chinese medicine gynostemma pentaphylla buccal tablet Download PDFInfo
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- CN102406690B CN102406690B CN201110390559.6A CN201110390559A CN102406690B CN 102406690 B CN102406690 B CN 102406690B CN 201110390559 A CN201110390559 A CN 201110390559A CN 102406690 B CN102406690 B CN 102406690B
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- herb gynostemmae
- gynostemmae pentaphylli
- chinese medicine
- buccal tablet
- hydroxypropyl cellulose
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Abstract
The invention relates to a traditional Chinese medicine preparation, and in particular relates to a traditional Chinese medicine gynostemma pentaphylla buccal tablet. The traditional Chinese medicine gynostemma pentaphylla buccal tablet provided by the invention is prepared from the following raw materials in weight ratio based on 1000 tablets: 100g of gynostemma pentaphylla, 1-500g of filler, 1-40g of adhesive, 1-10g of glidant and 0.1-2g of lubricant.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese Medicine Jiaogulan buccal tablet.
Background technology:
Herb Gynostemmae Pentaphylli is perennial root plant, is distributed widely in subtropical zone and north subtropical area.Cold in nature, sweet in the mouth, have QI invigorating, calm the nerves, and the effect of blood pressure lowering, " elixir grass " of among the people being called " mystery ", is classified as position first of " rare Chinese medicine " in Spark Program.In Herb Gynostemmae Pentaphylli, contain saponin constituent, Herb Gynostemmae Pentaphylli total glycosides capsule has anti-aging effects, Herb Gynostemmae Pentaphylli belongs to deficiency syndrome person to Senile Memory Deficits, hyperlipemia, senile chronic bronchitis, malignant tumor, thrombocytopenia, leukopenia and old poliosis etc., all has certain treatment or improvement effect.
Herb Gynostemmae Pentaphylli product in the market has, gynostemma pentaphylla granule, and gynostemium pentaphylla oral liquids etc., it is reported, long-term taking gynostemma pentaphyllum extract or electuary March～1 year, old people's poliosis reduces more than 25%.Gypenoside is the hair conditioner that primary raw material can be made into control poliosis.Herb Gynostemmae Pentaphylli can be improved scalp microcirculation, promotes lipid to discharge, and improves and recovers cell viability, and this may be the mechanism of its control poliosis.
The effect of Herb Gynostemmae Pentaphylli total glycosides tablet
Herb Gynostemmae Pentaphylli total glycosides tablet main component is for being Herb Gynostemmae Pentaphylli total glycosides, by Herb Gynostemmae Pentaphylli separation and Extraction, obtain 83 kinds of saponin monomers with ginsenoside's basic structure, be collectively referred to as Herb Gynostemmae Pentaphylli total glycosides, wherein six kinds is exactly ginsenoside, the equal tool of all the other monomers reaches agate ester alkanols structure, can be considered protopanoxadiol or Protopanaxatriol's isomer.Total saponin content is three times of Korean Ginseng, therefore has the laudatory title of " southern Radix Ginseng ".
According to above composition, can learn that Herb Gynostemmae Pentaphylli total glycosides tablet effect is blood fat reducing.The spleen invigorating of nourishing heart, QI invigorating and blood regulating, expectorant blood stasis dispelling.Mainly be applicable to hyperlipidemia, see that had palpitation breathes hard, limb fiber crops uncomfortable in chest, dizziness and headache, forgetful tinnitus, unconsciously sweat and tire, or heart deficiency of spleen-QI, the stagnation of phlegm blood stasis person such as distension and fullness in the abdomen.
In addition, the effect of Herb Gynostemmae Pentaphylli total glycosides tablet also has prevention of arterial sclerosis, and blood circulation promoting, improves old people's cold limbs, numbness, handicapped symptom; Enhancing body resistance and immunity, resisting fatigue, defying age; Rosemary Essence Oil, tranquillizing and allaying excitement, improves sleep Deng，You enterprise and is processed into Herb Gynostemmae Pentaphylli tea, is convenient to people and drinks.
Buccal tablet refers to be contained in oral cavity compressed tablet ，Neng Dui oral cavity and the lasting drug effect of pharyngeal generation of slowly dissolving, buccal tablet because of its good mouthfeel and easily instructions of taking be subject to the welcome of extensive patients.But also there is following problem in traditional Chinese medicine mouth buccal tablet: sensory issues, the sensation after buccal tablet entrance makes the problem of development person's headache often.Stability problem, buccal tablet tends to cause because of moisture absorption the even decline of drug content of variation of outward appearance.
The present invention, through research, has invented a kind of correctives that do not add, and mouthfeel is good, rapidly disintegrate in stability Qiang， oral cavity, without grittiness, to oral mucosa nonirritant, there is QI invigorating, calm the nerves, the Herb Gynostemmae Pentaphylli troche of the effect of blood pressure lowering, provides a kind of new preparation and formula.
Summary of the invention:
Traditional Chinese medicine mouth buccal tablet of the present invention is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
A buccal tablet, is characterized in that, with the raw material of following weight proportion, is prepared from: Herb Gynostemmae Pentaphylli 100g, and all the other are for to be selected from: the medicine acceptable carrier of filler, binding agent, fluidizer and lubricant, wherein:
Filler 1-500g
Binding agent 1-40g
Fluidizer 1-10g
Lubricant 0.1-2g.
Be more than unit of weight, can be prepared into 1000, tablet, but according to production scale, unit can be also kg that t etc. determine according to actual needs consumption, but each composition weight ratio are constant.
Wherein:
Filler is selected from: starch, dextrin, sucrose, microcrystalline Cellulose, lactose, modified starch, pregelatinized Starch, low-substituted hydroxypropyl cellulose, glucose, mannose, xylitol, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose;
Binding agent is selected from, and starch, pregelatinized Starch, dextrin, maltodextrin, sucrose, arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, Polyethylene Glycol, polyethylene adjoin pyrrolidone, xanthan gum, hydroxypropyl cellulose and hydroxypropyl emthylcellulose;
Fluidizer is selected from, and cruel, the single Laurel sucrose acid of micropowder silica gel, magnesium stearate, calcium stearate, zinc stearate, glyceryl monostearate, Polyethylene Glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyethylene monostearate is cruel, sodium laurylsulfate, magnesium laurylsulfate, Stepanol MG and Pulvis Talci;
Lubricant is selected from, hydrophobic lubricant, as: magnesium stearate, Pulvis Talci.
Preferred formula of the present invention is as follows:
Herb Gynostemmae Pentaphylli 100g
Filler 150-450g
Binding agent 15-30g
Fluidizer 5-10g.
Lubricant 0.5-2g.
Preferred formula of the present invention is as follows:
Herb Gynostemmae Pentaphylli 100g
Filler 220g
Binding agent 20g
Fluidizer 10g.
Lubricant 1g.
Most preferred formula of the present invention is as follows:
Herb Gynostemmae Pentaphylli 100g
Filler, low-substituted hydroxypropyl cellulose 220g
Binding agent, hydroxypropyl cellulose 20g
Fluidizer, micropowder silica gel 10g.
Lubricant, magnesium stearate 1g.
The preparation method of buccal tablet of the present invention, is characterized in that, comprises the following steps:
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation adds lubricant direct compression to make 1000 tablets of tablets.
Special character of the present invention is existing preparation technology to improve, and Herb Gynostemmae Pentaphylli is revised as to micronizing with decocting in water or alcohol extraction, simultaneously by the screening of adjuvant, obtains a kind of Herb Gynostemmae Pentaphylli tablet that is applicable to sucking.
The non-medicinal component that water extraction or alcohol extraction process propose is more, and the content difference opposite sex is large and hygroscopicity is large; Can disturb the detection of drug standard, can not accurately control drug quality, technique is unstable; The advantages such as the present invention proposes Herb Gynostemmae Pentaphylli to obtain powder by micronizing, can effective ingredient better be discharged Herb Gynostemmae Pentaphylli cell pulverization, reaches good stability simultaneously, and drug effect improves, and mouthfeel is good.
Buccal tablet of the present invention compared with prior art, has therapeutic effect good, few side effects, and instant effect, mouthfeel is good, and the quality guarantee period of medicament phase is long, good stability, cost is low, and preparation technology is simpler, has saved the plurality of advantages such as time of preparing medicine.
Adjuvant screening process of the present invention is as follows:
Supplementary material (g)/every 1000
| Prescription number | 1 | 2 | 3 | 4 | 5 | 6 |
| Herb Gynostemmae Pentaphylli powder | 50 | 100 | 100 | 100 | 100 | 150 |
| Lactose | ? | 100 | 250 | ? | ? | ? |
| Low-substituted hydroxypropyl cellulose | 100 | ? | ? | 220 | 200 | ? |
| Carboxymethyl starch sodium | 100 | 150 | ? | ? | ? | 200 |
| Polyvinylpolypyrrolidone | 10 | 15 | ? | ? | 25 | 30 |
| Hydroxypropyl cellulose | 10 | ? | 50 | 20 | 40 | ? |
| Magnesium stearate | 2 | 3 | 4 | 1 | 5 | 2 |
| Micropowder silica gel | 5 | 15 | ? | 10 | 5 | ? |
Above result of the test shows: the content no significant difference of six prescriptions.Prescription 2 and prescription 5 powder flowbilitys are bad, have certain aberration, and hardness is bad; 1 hardness of writing out a prescription is less than normal, is difficult for coating; In the 3 dry powder sheeting processes of writing out a prescription, produce to hang and cover phenomenon; 6 mobility of writing out a prescription are not fine; Prescription 4 is all better at indices such as outward appearance, hardness, disintegration, content, so select prescription 4 as the further research of basic prescription.By amplifying sample, manufacture experimently, 4 the proportioning of writing out a prescription is best proportioning.
The specific embodiment:
With specific embodiment, the present invention is elaborated below.Method of the present invention is the technological means that those skilled in the art can grasp and use.Following examples are implementation example of the present invention, and the part embodiment for the claims in the present invention, should not be construed as the limiting to the claimed invention going up in all senses.
Embodiment 1
Herb Gynostemmae Pentaphylli 100g
Low-substituted hydroxypropyl cellulose 220g
Hydroxypropyl cellulose 20g
Micropowder silica gel 10g
Magnesium stearate 1g.
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation, dry, screening, adds lubricant direct compression to make 1000 tablets of tablets.
Embodiment 2
Herb Gynostemmae Pentaphylli 100g
Low-substituted hydroxypropyl cellulose 150g
Hydroxypropyl cellulose 10g
Micropowder silica gel 1g
Magnesium stearate 0.1g.
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation, dry, screening, adds lubricant direct compression to make 1000 tablets of tablets.
Embodiment 3
Herb Gynostemmae Pentaphylli 100g
Low-substituted hydroxypropyl cellulose 500g
Hydroxypropyl cellulose 40g
Micropowder silica gel 10g
Magnesium stearate 2g.
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation, dry, screening, adds lubricant direct compression to make 1000 tablets of tablets.
Embodiment 4
Herb Gynostemmae Pentaphylli 100g
Microcrystalline Cellulose 220g
Pregelatinized Starch 20g
Micropowder silica gel 10g
Magnesium stearate 1g.
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation, dry, screening, adds lubricant direct compression to make 1000 tablets of tablets.
Embodiment 5
Herb Gynostemmae Pentaphylli 100g
Lactose 150g
Maltodextrin 15g
Micropowder silica gel 5g
Magnesium stearate 0.5g.
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation, dry, screening, adds lubricant direct compression to make 1000 tablets of tablets.
Embodiment 6
Herb Gynostemmae Pentaphylli 100g
Xylitol 450g
Ethyl cellulose 30g
Micropowder silica gel 105g
Magnesium stearate 2g.
Get Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add filler, binding agent, fluidizer mixing granulation, dry, screening, adds lubricant direct compression to make 1000 tablets of tablets.
Claims (2)
1. a Chinese Medicine Jiaogulan buccal tablet, is characterized in that, consists of the following composition:
Herb Gynostemmae Pentaphylli 100g
Low-substituted hydroxypropyl cellulose 220g
Hydroxypropyl cellulose 20g
Micropowder silica gel 10g
Magnesium stearate 1g.
2. a preparation method for Chinese Medicine Jiaogulan buccal tablet, is characterized in that, comprises the following steps:
Get 100g Herb Gynostemmae Pentaphylli, with jet mill, pulverize, make particle diameter be less than 50 μ m, add 220g low-substituted hydroxypropyl cellulose, 20g hydroxypropyl cellulose, 10g micropowder silica gel mixing granulation, dry, screening, adds 1g magnesium stearate direct compression to make 1000 tablets of tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110390559.6A CN102406690B (en) | 2011-11-30 | 2011-11-30 | Traditional Chinese medicine gynostemma pentaphylla buccal tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110390559.6A CN102406690B (en) | 2011-11-30 | 2011-11-30 | Traditional Chinese medicine gynostemma pentaphylla buccal tablet |
Publications (2)
| Publication Number | Publication Date |
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| CN102406690A CN102406690A (en) | 2012-04-11 |
| CN102406690B true CN102406690B (en) | 2014-01-15 |
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| CN201110390559.6A Expired - Fee Related CN102406690B (en) | 2011-11-30 | 2011-11-30 | Traditional Chinese medicine gynostemma pentaphylla buccal tablet |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102630789A (en) * | 2012-05-07 | 2012-08-15 | 沈志刚 | Green processing method of Gynostemma pentaphylla |
| CN103432189A (en) * | 2013-09-06 | 2013-12-11 | 李嘉 | Gynostemma pentaphylla buccal tablet and preparation method thereof |
| CN103829255A (en) * | 2014-02-11 | 2014-06-04 | 毛庆云 | Blood pressure lowering buccal tablet and preparation method thereof |
| JP6580414B2 (en) * | 2015-08-07 | 2019-09-25 | 小林製薬株式会社 | Herbal powder-containing tablets |
| CN107232546A (en) * | 2017-07-12 | 2017-10-10 | 贵州三金圣果绿色食品有限责任公司 | A kind of Kiwi berry buccal tablet and preparation method thereof |
| CN113181132A (en) * | 2021-04-27 | 2021-07-30 | 宁波西敦医药包衣科技有限公司 | Chinese herbal medicine superfine powder composition, preparation method and application of Chinese herbal medicine superfine powder tablet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1762374A (en) * | 2004-10-18 | 2006-04-26 | 孙民富 | Gypenosides pills formula and its preparation method |
| CN102178792A (en) * | 2010-11-12 | 2011-09-14 | 中山市中智药业集团有限公司 | Shiqi exogenous Chinese medicinal buccal tablets |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1762374A (en) * | 2004-10-18 | 2006-04-26 | 孙民富 | Gypenosides pills formula and its preparation method |
| CN102178792A (en) * | 2010-11-12 | 2011-09-14 | 中山市中智药业集团有限公司 | Shiqi exogenous Chinese medicinal buccal tablets |
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| CN102406690A (en) | 2012-04-11 |
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Granted publication date: 20140115 Termination date: 20171130 |