CN103251813A - Medicine for treating chronic bronchitis type tussive and preparation method thereof - Google Patents
Medicine for treating chronic bronchitis type tussive and preparation method thereof Download PDFInfo
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- CN103251813A CN103251813A CN2013102128255A CN201310212825A CN103251813A CN 103251813 A CN103251813 A CN 103251813A CN 2013102128255 A CN2013102128255 A CN 2013102128255A CN 201310212825 A CN201310212825 A CN 201310212825A CN 103251813 A CN103251813 A CN 103251813A
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Abstract
The invention discloses a medicine for treating chronic bronchitis type tussive and a preparation method thereof. The medicine is prepared by the following medicines by weight percentage: ginseng, perilla leaf, dried tangerine, bitter orange, common hogfenneI root, pinellia ternate, the root of kudzu vine, the bulb of fritillary, libanotis buchtormensis and the like. The medicine disclosed by the invention has the functions of clearing fire and tonifying yin, clearing lung and eliminating phlegm, and moistening lung to arrest cough; and when the meidicne is applied to treatment of the chronic bronchitis type tussive, the curative effect is good, the disease is not easy to recur, and the cure rate is high.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of the chronic bronchitis cough and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Cough is the cardinal symptom of respiratory system disease, is dry cough seldom as cough but no phlegm or amount of expectoration, is common in acute pharyngolaryngitis, bronchitic initial stage; Foreign body in the bronchus is more common in the acute cough that takes place suddenly; Long-term chronic cough is more common in chronic bronchitis, pulmonary tuberculosis etc.Character cough but no phlegm or the amount of expectoration of cough are few, are called dry cough.Dry cough or irritable cough are common in acute or chronic pharyngolaryngitis, laryngeal carcinoma, acute bronchitis initial stage, trachea pressurized, foreign body in bronchus, tumor of bronchus, pleural diseases, primary pulmonary hypertension and mitral stenosis etc.Cough is called the moist cough with expectoration, is common in chronic bronchitis, bronchiectasis, pneumonia, pulmonary abscess and cavernous pulmonary tuberculosis etc.Cough has influenced people's daily life and work.At present, because Western medicine can't effectively be treated cough, and has certain side effect, therefore, there is very big demand in people to the Chinese medicine of effective treatment chronic bronchitis cough.
Summary of the invention
The inventor has found the medicine of effective treatment chronic bronchitis cough finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine for the treatment of the chronic bronchitis cough.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Ginseng, Folium Perillae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Peucedani, the Rhizoma Pinelliae, Radix Puerariae, the Radix Aucklandiae, Radix Platycodonis, Poria, Pseudobulbus Coelogynes corymbosae, Radix Zanthoxyli Spinifolii, Radix Libanotidis buchotomensis and Radix Glycyrrhizae to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of chronic bronchitis cough.Wherein select for use Radix Ginseng to be because its nature and flavor are sweet little sweet, temperature is gone into spleen, lung meridian, and strongly invigorating primordial QI is arranged, promote the production of body fluid admittedly take off, the function of calming the nerves, it is deficient to control impairment caused by overstrain, lack of appetite, asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition is quenched one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Selecting Folium Perillae for use is that temperature is gone into lung, spleen channel because of its nature and flavor suffering, deliver, and cold expelling, the function of regulating the flow of vital energy and seeking, the wind and cold that cures cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement, and can solving toxin of fish and crab.Selecting Pericarpium Citri Reticulatae for use is that temperature is returned lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged because of its nature and flavor hardship, suffering, and the function of drying dampness to eliminate phlegm is controlled fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Selecting Fructus Aurantii for use is that lung, spleen, large intestine channel are gone in cold, and dispelling the stagnated QI is arranged because of its nature and flavor toil, row expectorant, and the function of removing food stagnancy is controlled chest and diaphragm expectorant and is stagnated, the feeling of stuffiness in chest, the side of body expands, food stagnation, eructation, vomiting weighs proctoptosis, uterine prolapse behind the dysentery.Selecting Radix Peucedani for use is because of its nature and flavor suffering, hardship, is slightly cold, and returns lung meridian, and diffusing wind heat clearing away is arranged, and the function of lowering the adverse-rising QI to resolve phlegm is controlled the cough due to pathogenic wind-heat, abundant expectoration, and the expectorant dyspnea of heat type is full, and it is yellow thick to cough up phlegm.Selecting the Rhizoma Pinelliae for use is because of its nature and flavor suffering, and temperature is poisonous, goes into spleen, stomach warp, and drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, and the function of dissolving lump and resolving mass is controlled the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select for use Radix Puerariae to be because the sweet suffering of its nature and flavor is flat, go into spleen, stomach warp, the yang invigorating expelling pathogenic factors from muscles is arranged, rash antidiarrheal, the function that relieving restlessness is quenched the thirst, it is cold to cure the wound, warm, headache, stiffness of the nape, dysphoria with smothery sensation disappears and drinks, and has loose bowels, and dysentery, abnormal pigmentary deposit on the skin are examined not saturating, hypertension, angina pectoris, deafness.Select for use the Radix Aucklandiae to be because its nature and flavor are arduous, temperature is gone into lung, liver, spleen channel, and promoting the circulation of QI to relieve pain are arranged, and the function of warming middle-JIAO for easing the stomach is controlled the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, and dysentery tenesmus, colic of cold type are had loose bowels in vomiting.Select for use Radix Platycodonis to be because its nature and flavor toil is flat, go into lung, stomach warp, lung qi dispersing gas is arranged out, the function of the evacuation of pus of eliminating the phlegm is controlled the exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.Select for use Poria to be because its property slightly sweet flavor is flat, go into the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select for use Pseudobulbus Coelogynes corymbosae to be because its nature and flavor are sweet, Xin Liang has heat clearing away, cough-relieving, and the function of hemostasis analgesic therapy is controlled bronchitis, flu.Select for use Radix Zanthoxyli Spinifolii to be because its property and flavor of peppery and warm has expelling wind and cold, invigorate blood circulation, the analgesic function is controlled the cough due to wind and cold, rheumatic numbness.Select for use Radix Libanotidis buchotomensis to be because its property and flavor of peppery and warm has analgesia, spleen invigorating, cough-relieving, the function of detoxifcation, the cough that cures cold, headache, toothache, rheumatism, numbness.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in the following weight scope
Radix Ginseng 8-15 gram Folium Perillae 10-20 gram Pericarpium Citri Reticulatae 8-15 gram
Fructus Aurantii 8-15 gram Radix Peucedani 15-25 gram Rhizoma Pinelliae 8-15 gram
Radix puerariae 10-20 gram Radix Aucklandiae 8-15 gram Radix Platycodonis 8-15 gram
Poria 10-20 gram Pseudobulbus Coelogynes corymbosae 15-25 gram Radix Zanthoxyli Spinifolii 8-12 gram
Radix Libanotidis buchotomensis 15-25 gram Radix Glycyrrhizae 8-15 gram
Wherein, be preferably
Radix Ginseng 10 gram Folium Perillaes 15 gram Pericarpium Citri Reticulataes 10 grams
The Fructus Aurantii 10 gram Radix Peucedanis 20 gram Rhizoma Pinelliaes 10 grams
The Radix puerariae 15 gram Radix Aucklandiae 10 gram Radix Platycodoniss 10 grams
Poria 15 gram Pseudobulbus Coelogynes corymbosaes 20 gram Radix Zanthoxyli Spinifoliis 10 grams
Radix Libanotidis buchotomensis 20 gram Radix Glycyrrhizaes 10 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Radix Ginseng: except removing LU, cutting;
2, Folium Perillae: choose decontamination, dry;
3, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
4, Fructus Aurantii: remove flesh, nuclear, edulcoration soaks slightly, pulls out, moistens softly, can pinch doubling degree of being with hands, and section is dried;
5, Radix Peucedani: get crude drug, remove impurity, clean, run through, shave, drying or cold drying, sieve removes chip;
6, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
7, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;
8, the Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;
9, Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through the back section, dry;
10, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
11, Pseudobulbus Coelogynes corymbosae: choose clean impurity, dry;
12, Radix Zanthoxyli Spinifolii: spring, summer, Qiu Sanji all can excavate, and dry, or get root bark and dry;
13, Radix Libanotidis buchotomensis: Xia Qiu excavates the root of plant bottom, is soaked in water, and pulls out, runs through, and section is dried;
14, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing.
Two, preparation
1, Radix Ginseng, Folium Perillae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Peucedani, the Rhizoma Pinelliae, Radix Puerariae, the Radix Aucklandiae, Radix Platycodonis, Poria, Pseudobulbus Coelogynes corymbosae, Radix Zanthoxyli Spinifolii, Radix Libanotidis buchotomensis, the Radix Glycyrrhizae with described weight decocts with water, add for the first time 4 times of amounts of water, soaked 60 minutes, intense fire decocts boiling 30 minutes, used slow fire boiling again 20 minutes, filter and namely get decoction liquor, be the oral liquid medicine first time.
2, the medicinal residues after will filtering add 2 times of amounts of water, and intense fire was used slow fire boiling 20 minutes after decocting boiling again, was the oral liquid medicine second time.
Medicine of the present invention has the nourishing YIN of relieving inflammation or internal heat, removing heat from the lung and dissipating phlegm, and the pharmic function of nourishing the lung to arrest cough is used for chronic bronchitis cough good effect, is difficult for recurrence, the cure rate height.
The specific embodiment
Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested the routine animal toxicity test of medicine of the present invention and the clinical observation on the therapeutic effect of having comprised and test.
The animal toxicity test of [test example 1] medicine of the present invention
Get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day 2 times, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy chronic bronchitis cough of the present invention
1, physical data
Accept out-patient's 160 examples for medical treatment, light-duty cough 90 examples wherein, heavy cough 70 examples.
2, diagnostic criteria
Light-duty cough: referring to for 3 weeks with interior cough, is the modal symptom of Pneumology Department outpatient service.The cause of disease comprises that virus, mycoplasma or antibacterial comprise acute bronchitis, pneumonia, respiratory tract infection, pulmonary tuberculosis, the foreign body in trachea that causes.
Heavy cough: the persistent period surpasses 3 weeks, sustainable several years even lasting many decades.The reason of chronic cough is comparatively complicated, comprises that cough variant asthma (allergic bronchitis), upper respiratory tract cough syndrome (anaphylaxis rhinotracheitis), stomach esophagus backflow, eosinophilia bronchitis, chronic bronchitis etc.Wherein common with cough variant asthma and upper respiratory tract cough syndrome.
3, Therapeutic Method
Select above-mentioned medicament for use, take to the patient, light-duty patient takes 1 dose at every turn, every day early, respectively obey 1 time evening, 10 days is a course for the treatment of, takes three courses for the treatment of continuously.Heavy patient takes 1 dose at every turn, and every day is early, middle and late respectively obeys 1 time, and 10 days is a course for the treatment of, takes five courses for the treatment of continuously.
4, efficacy assessment standard
Produce effects: treatment back clinical symptom disappearance, it is normal that body constitution is recovered, and observes and do not have the recidivist half a year;
Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;
Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy chronic bronchitis of the present invention cough patient 160 examples, light-duty cough 90 examples wherein, produce effects 86 examples as a result, obvious effective rate is 95.56%, 2 examples that take a turn for the better, improvement rate is 2.22%, invalid 2 examples, total effective rate is 98.78%; Heavy cough 70 examples, produce effects 60 examples as a result, obvious effective rate is 85.71%, 2 examples that take a turn for the better, improvement rate is 2.86%, invalid 8 examples, total effective rate is 88.57%.
Claims (3)
1. treat the medicine that chronic bronchitis is coughed for one kind, it is characterized in that: it is to be made by the crude drug in the following weight range:
Radix Ginseng 8-15 gram Folium Perillae 10-20 gram Pericarpium Citri Reticulatae 8-15 gram
Fructus Aurantii 8-15 gram Radix Peucedani 15-25 gram Rhizoma Pinelliae 8-15 gram
Radix puerariae 10-20 gram Radix Aucklandiae 8-15 gram Radix Platycodonis 8-15 gram
Poria 10-20 gram Pseudobulbus Coelogynes corymbosae 15-25 gram Radix Zanthoxyli Spinifolii 8-12 gram
Radix Libanotidis buchotomensis 15-25 gram Radix Glycyrrhizae 8-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Ginseng 10 gram Folium Perillaes 15 gram Pericarpium Citri Reticulataes 10 grams
The Fructus Aurantii 10 gram Radix Peucedanis 20 gram Rhizoma Pinelliaes 10 grams
The Radix puerariae 15 gram Radix Aucklandiae 10 gram Radix Platycodoniss 10 grams
Poria 15 gram Pseudobulbus Coelogynes corymbosaes 20 gram Radix Zanthoxyli Spinifoliis 10 grams
Radix Libanotidis buchotomensis 20 gram Radix Glycyrrhizaes 10 grams.
3. according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
(1) gets the raw materials ready
(1) Radix Ginseng: except removing LU, cutting;
(2) Folium Perillae: choose decontamination, dry;
(3) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
(4) Fructus Aurantii: remove flesh, nuclear, edulcoration soaks slightly, pulls out, moistens softly, can pinch doubling degree of being with hands, and section is dried;
(5) Radix Peucedani: get crude drug, remove impurity, clean, run through, shave, drying or cold drying, sieve removes chip;
(6) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
(7) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;
(8) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;
(9) Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through the back section, dry;
(10) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(11) Pseudobulbus Coelogynes corymbosae: choose clean impurity, dry;
(12) Radix Zanthoxyli Spinifolii: spring, summer, Qiu Sanji all can excavate, and dry, or get root bark and dry;
(13) Radix Libanotidis buchotomensis: Xia Qiu excavates the root of plant bottom, is soaked in water, and pulls out, runs through, and section is dried;
(14) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
(2) preparation
(1) Radix Ginseng, Folium Perillae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Peucedani, the Rhizoma Pinelliae, Radix Puerariae, the Radix Aucklandiae, Radix Platycodonis, Poria, Pseudobulbus Coelogynes corymbosae, Radix Zanthoxyli Spinifolii, Radix Libanotidis buchotomensis, the Radix Glycyrrhizae with described weight decocts with water, add for the first time 4 times of amounts of water, soaked 60 minutes, intense fire decocts boiling 30 minutes, used slow fire boiling again 20 minutes, filter and namely get decoction liquor, be the oral liquid medicine first time;
(2) medicinal residues after will filtering add 2 times of amounts of water, and intense fire was used slow fire boiling 20 minutes after decocting boiling again, was the oral liquid medicine second time.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103907991A (en) * | 2014-03-04 | 2014-07-09 | 太仓市伟基生物科技有限公司 | Traditional Chinese medicine beverage used for treating spleen lung kidney deficiency cough of children, and preparation method thereof |
| CN114558066A (en) * | 2022-03-28 | 2022-05-31 | 北京中医药大学 | Pharmaceutical composition for treating cough variant asthma and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045153A (en) * | 2006-08-30 | 2007-10-03 | 湖南中达骛马制药有限责任公司 | Traditional Chinese medicine for treating cold |
| CN101757337A (en) * | 2008-11-20 | 2010-06-30 | 杨汝静 | Phlegm-resolving pill |
-
2013
- 2013-06-02 CN CN2013102128255A patent/CN103251813A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045153A (en) * | 2006-08-30 | 2007-10-03 | 湖南中达骛马制药有限责任公司 | Traditional Chinese medicine for treating cold |
| CN101757337A (en) * | 2008-11-20 | 2010-06-30 | 杨汝静 | Phlegm-resolving pill |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103907991A (en) * | 2014-03-04 | 2014-07-09 | 太仓市伟基生物科技有限公司 | Traditional Chinese medicine beverage used for treating spleen lung kidney deficiency cough of children, and preparation method thereof |
| CN114558066A (en) * | 2022-03-28 | 2022-05-31 | 北京中医药大学 | Pharmaceutical composition for treating cough variant asthma and preparation method thereof |
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Application publication date: 20130821 |