CN103405637A - Drug for treating neurosis and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for treating neurosis and a preparation method thereof. The drug is mainly prepared from fruits of Chinese wolfberry, chrysanthemum, adenophora tetraphylla, radix ophiopogonis, radix bupleuri, angelica sinensis, radix paeoniae alba, concha margaritiferallsta, keel, tuckahoe and the like in a certain weight proportion. The drug disclosed by the invention has the functions of relieving muscular spasm and tranquilizing the mind, nourishing yin to moisten the lung and clearing away the heart-fire and relieving restlessness, and is used for treating the neurosis.

Description

A kind of neurosal medicine and preparation method thereof for the treatment of

Technical field

The present invention relates to a kind of neurosal medicine and preparation method thereof for the treatment of, belong to the field of Chinese medicines.

Technical background

Neurosis (neurosis) is once called as neurosis, be a kind of main manifestations be the decline of ergasia ability, worry, anxiety, anxiety, depression, fear, force, the mental disorder of hypochondriasis symptom, dissociation symptom, conversion symptom or neurasthenia symptom.Along with the in-depth to neurosis understanding, a series of differentiation has also occurred in its concept, the general trend of this differentiation is become more and more in-depth constantly alienation of intension, result is in ICD-10, almost completely to have abandoned this concept of neurosis, it is seven kinds of different obstacles that this class disease is dismembered, and is referred to as neurosis, stress be correlated with and somatoform disorder.

At present, because Western medicine can't effectively be treated neurosis, and easily recurrence, and more side effect is arranged, therefore, there is very large demand in people to the neurosal Chinese medicine of effective treatment.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical repeatedly test and checking, has finally found the neurosal medicine of effective treatment, thereby has completed the present invention.

Purpose of the present invention just is to provide a kind ofly can effectively treat neurosal composition of medicine.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Fructus Lycii, Flos Chrysanthemi, Radix Adenophorae, Radix Ophiopogonis, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygalae, the Rhizoma Pinelliae, Concha Margaritifera, Os Draconis, Concha Ostreae, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Platycladi, Fructus Corni, Poria, Rhizoma Atractylodis Macrocephalae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat neurosal recurrence.Wherein select Fructus Lycii to be because its nature and flavor are sweet, flat, nourishing kidney is arranged, lung moistening, tonifying liver, the function of improving eyesight, control hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quench one's thirst, and loses clear.Select Flos Chrysanthemi to be because its nature and flavor sweetness and bitterness is cool, enter lung, Liver Channel, have dispelling wind, the heat that disappears, and improving eyesight, the function of removing toxic substances, control headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Select Radix Adenophorae to be because its nature and flavor are sweet, be slightly cold, attach to the lung and stomach meridians, nourishing YIN and clearing away lung-heat is arranged, reduce phlegm, the function of QI invigorating, control lung-heat type cough, deficiency of YIN phthisical cough, and dry cough expectorant is glutinous, deficiency of both vital energy and Yin, restlessness and fever with thirst.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, control dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, calentura Tianjin wound, dry mouth and throat, constipation.Select Radix Bupleuri to be because its nature and flavor hardship is cool, enter liver, gallbladder meridian, reconciling superficies and interior is arranged, soothing the liver, the function of yang invigorating, control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, nourishing blood to suppress the hyperactive liver is arranged, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Selecting Radix Polygalae is that temperature, enter the heart, kidney channel, and the Fructus Alpiniae Oxyphyllae of calming the nerves is arranged, and eliminates the phlegm because of its nature and flavor toil, and the function of resolving depression, control palpitation with fear, forgetful, nocturnal emission, and insomnia, cough ant phlegm, the carbuncle skin ulcer is swollen.Selecting the Rhizoma Pinelliae is because of its nature and flavor suffering, and temperature is poisonous, enters spleen, stomach warp, and drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, and the function of dissolving lump and resolving mass, control the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warps, suppressing the hyperactive liver is arranged, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, control dizziness, tinnitus, cardiopalmus, insomnia, demented ， Jing Epilepsy, spit blood, epistaxis, metrorrhagia.Select Os Draconis to be because its property sweet-puckery flavor is flat, be included into the heart, liver, kidney, large intestine channel, tranquillizing the mind by relieving convulsion is arranged, the function of arresting sweating controlling nocturnal emission with astringent drugs, control frightened Epilepsy demented, and palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, yin fluid astringing is arranged, YANG hyperactivity suppressing, hidroschesis, the function of arresting seminal emission, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, control the calentura excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, send out the speckle dermexanthesis.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enter liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quench one's thirst, frequency of micturition, deafness, blurred vision.Select Semen Platycladi to be because its nature and flavor are sweet, flat, enter the heart, liver, spleen channel, tranquilizing by nourishing the heart is arranged, the function of loosening bowel to relieve constipation, control palpitation with fear, insomnia, seminal emission, night sweat, the function of constipation.(189) selecting Fructus Corni is that tepor, enter liver, kidney channel, and invigorating the liver and kidney is arranged because of its nature and flavor acid, and arresting seminal emission gas is Gu the function of collapse is controlled soreness of waist and knee joint, dizzy, tinnitus, and sexual impotence, seminal emission, frequent micturition, the deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enter spleen, stomach warp, and spleen reinforcing is arranged, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea uneasiness.

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Fructus Lycii 8-15 gram Flos Chrysanthemi 8-15 gram Radix Adenophorae 8-15 grams

Radix Ophiopogonis 8-15 gram Radix Bupleuri 10-20 gram Radix Angelicae Sinensis 10-20 grams

The Radix Paeoniae Alba 10-20 gram Radix Polygalae 10-20 gram Rhizoma Pinelliae 10-20 grams

Concha Margaritifera 25-35 cron bone 25-35 gram Concha Ostreae 10-15 grams

Radix Rehmanniae 10-20 gram Radix Rehmanniae Preparata 10-20 gram Semen Platycladi 10-20 grams

Fructus Corni 10-20 gram Poria 10-15 gram Rhizoma Atractylodis Macrocephalae 10-15 grams

Preferable amount is

Fructus Lycii 10 gram Flos Chrysanthemi 10 gram Radix Adenophorae 10 grams

Radix Ophiopogonis 10 gram Radix Bupleuri 15 gram Radix Angelicae Sinensis 15 grams

The Radix Paeoniae Alba 15 gram Radix Polygalae 15 gram Rhizoma Pinelliae 15 grams

Concha Margaritifera 30 cron bone 30 gram Concha Ostreae 12 grams

Radix Rehmanniae 15 gram Radix Rehmanniae Preparata 15 gram Semen Platycladi 15 grams

The Fructus Corni 15 gram Poria 12 gram Rhizoma Atractylodis Macrocephalae 12 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

2, Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;

3, Radix Adenophorae: remove fibrous root, clean, scrape off rough bark, drying;

4, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, then clean and dry;

5, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;

6, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;

7, the Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

8, Radix Polygalae: choose decontamination, cutting, sieve dedust bits;

9, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

10, Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;

11, Os Draconis: outwash earth, smash;

12, Concha Ostreae: clean, dry, pulverize use;

13, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;

14, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, cut into slices, drying;

15, Semen Platycladi: choose clean impurity, remove residual shell and plant skin;

16, Fructus Corni: clean, except removal core and impurity, dry;

17, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

18, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dry.

Two, preparation

The Fructus Lycii of described weight, Flos Chrysanthemi, Radix Adenophorae, Radix Ophiopogonis, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygalae, the Rhizoma Pinelliae, Concha Margaritifera, Os Draconis, Concha Ostreae, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Platycladi, Fructus Corni, Poria, Rhizoma Atractylodis Macrocephalae medicine are put into to the container of boiling medicine, add 8 times of amounts of water, soaked 200 minutes, decoct with high heat boiling 25 minutes, used again slow fire boiling 30 minutes, filter and get final product, will decoct medicinal liquid and be equally divided into 4 doses and take.

Medicine of the present invention has tranquillizing the mind by relieving convulsion, nourishing YIN and moistening the lung, and the relieving restlessness that clears away heart-fire, the effect of reinforcing stomach reg fluid, treatment neurosis instant effect, short treating period, do not recur.

The specific embodiment

Below by test example, further set forth the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, every day 2 times, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 130 examples for medical treatment, its male patient's 60 examples, female patient 70 examples.

2, diagnostic criteria

Clinical manifestation is divided into the symptoms such as phobia, anxiety neurosis, obsession, hypochondria, neurasthenia.

Phobia refers to patient some situation, object or while with the people, associating to external world, produce thundering fear and nervous, and often with obvious autonomic nerve symptom, as blush, tachypnea, perspiration, cardiopalmus, blood pressure, feel sick, unable even faint etc.The patient knows that this fear reaction is undue or irrational perfectly well, but still repeatedly occurs, is difficult to control, so that does one's utmost to avoid causing frightened objective things or situation, or go to stand with fear, thereby affect its normal activity.

Anxiety neurosis refers to take extensively and persistence anxiety or the terrified uneasiness of repeatedly showing effect are the neurosis of main clinical characteristics.Often with autonomic nervous dysfunction, muscular tone and mobility's uneasiness, onset is not caused by actual threat or dangerous institute, its anxiety or terrified degree and real situation unbecoming.Be divided into clinically generalized anxiety disorder and panic attack.

Obsession is that to force symptom be a class neurosis of main clinical phase.The juvenile era of being everlasting morbidity, most slowly onsets, without obvious inducement, its fundamental symptoms is obsessive idea or obsessive intentions, often with compulsive act or behavior, can a kind ofly be main, also can concentrate symptom to have both at the same time.

Hypochondria: the patient worries or thinks the lasting over valued idea of oneself suffering from one or more serious physical diseases.Majority is slow onset, normal without obvious inducement.Clinical manifestation be take the hypochondriasis symptom as main, and companion's anxiety, depressive emotion, also often with various pain.The patient is concerned about especially to the health status of self, the sensation of each one of health is extremely paid close attention to, and then suspected that oneself is ill, requires doctor or relatives to sympathize with, though, through all negative discoveries of various inspections, worry still, suspect whether check result is wrong.Therefore, the patient seeks medical advice everywhere, repeatedly checks, often seeks so-called proved recipe, folk prescription, simultaneously, suspects again its curative effect.Most patients hypochondriasis symptom is single fixing, also has indivedual patients' symptom varied.The course of disease is tediously long, often causes somatic function impaired, and therapeutic effect is poor.

Neurasthenic feature is that spirit is easily excited and mental easily tired, often with symptoms such as emotion worry, irritability, sleep disorder, headache and multiple body discomforts, these symptoms can not be owing to physical disease, brain organic pathological changes or certain specific mental disorder.Course of disease delay, heavy when light during symptom, state of an illness fluctuation is normal relevant with psychosocial factor.Majority of cases was fallen ill in 16-40 between year, and sickness rate is without obvious sex difference, and the person of being engaged in mental work occupies the majority.

3, Therapeutic Method

Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day early, respectively take 1 evening, and 20 days is a course for the treatment of, takes continuously 4 courses for the treatment of.

4, efficacy assessment standard

Produce effects: transference cure, body constitution recover normal, observe 1 year without the recidivist;

Take a turn for the better: symptom is clearly better, and symptom fades away;

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy neurosis patient of the present invention 130 examples, produce effects 120 examples as a result, obvious effective rate is 92.31%, 6 examples that take a turn for the better, improvement rate is 4.62%, invalid 4 examples, total effective rate is 96.93%.

Claims (3)

1. treat neurosal medicine for one kind, it is characterized in that: it is to be made by the crude drug in following weight range:

Fructus Lycii 8-15 gram Flos Chrysanthemi 8-15 gram Radix Adenophorae 8-15 grams

Radix Ophiopogonis 8-15 gram Radix Bupleuri 10-20 gram Radix Angelicae Sinensis 10-20 grams

The Radix Paeoniae Alba 10-20 gram Radix Polygalae 10-20 gram Rhizoma Pinelliae 10-20 grams

Concha Margaritifera 25-35 cron bone 25-35 gram Concha Ostreae 10-15 grams

Radix Rehmanniae 10-20 gram Radix Rehmanniae Preparata 10-20 gram Semen Platycladi 10-20 grams

Fructus Corni 10-20 gram Poria 10-15 gram Rhizoma Atractylodis Macrocephalae 10-15 grams.

2. external used medicine according to claim 1, wherein the consumption of each crude drug is:

Fructus Lycii 10 gram Flos Chrysanthemi 10 gram Radix Adenophorae 10 grams

Radix Ophiopogonis 10 gram Radix Bupleuri 15 gram Radix Angelicae Sinensis 15 grams

The Radix Paeoniae Alba 15 gram Radix Polygalae 15 gram Rhizoma Pinelliae 15 grams

Concha Margaritifera 30 cron bone 30 gram Concha Ostreae 12 grams

Radix Rehmanniae 15 gram Radix Rehmanniae Preparata 15 gram Semen Platycladi 15 grams

The Fructus Corni 15 gram Poria 12 gram Rhizoma Atractylodis Macrocephalae 12 grams.

3. according to the preparation method of claim 1 or 2 described medicine, it comprises the following steps:

(1) get the raw materials ready

(1) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

(2) Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;

(3) Radix Adenophorae: remove fibrous root, clean, scrape off rough bark, drying;

(4) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, then clean and dry;

(5) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;

(6) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;

(7) Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(8) Radix Polygalae: choose decontamination, cutting, sieve dedust bits;

(9) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(10) Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;

(11) Os Draconis: outwash earth, smash;

(12) Concha Ostreae: clean, dry, pulverize use;

(13) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;

(14) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, cut into slices, drying;

(15) Semen Platycladi: choose clean impurity, remove residual shell and plant skin;

(16) Fructus Corni: clean, except removal core and impurity, dry;

(17) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(18) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dry;

(2) preparation

The Fructus Lycii of described weight, Flos Chrysanthemi, Radix Adenophorae, Radix Ophiopogonis, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygalae, the Rhizoma Pinelliae, Concha Margaritifera, Os Draconis, Concha Ostreae, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Platycladi, Fructus Corni, Poria, Rhizoma Atractylodis Macrocephalae medicine are put into to the container of boiling medicine, add 8 times of amounts of water, soaked 200 minutes, decoct with high heat boiling 25 minutes, used again slow fire boiling 30 minutes, filter and get final product, will decoct medicinal liquid and be equally divided into 4 doses and take.