CN101204575A - Chinese traditional medicine composite for depressive neurosis, preparation method and application thereof - Google Patents
Chinese traditional medicine composite for depressive neurosis, preparation method and application thereof Download PDFInfo
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- CN101204575A CN101204575A CNA2007103000164A CN200710300016A CN101204575A CN 101204575 A CN101204575 A CN 101204575A CN A2007103000164 A CNA2007103000164 A CN A2007103000164A CN 200710300016 A CN200710300016 A CN 200710300016A CN 101204575 A CN101204575 A CN 101204575A
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Abstract
The invention belongs to the field of a Chinese traditional medicine preparation and in particular relates to a Chinese traditional medicine combination for curing depressive neurosis as well as a preparation method and application thereof.The ingredients composition of the combination are: Chinese thorowax root of 10-20 proportion, atractylodes ovata of 10-30 proportion, white peony root of 10-30 proportion, Chinese angelica root of 8-20 proportion, indian bread of 20-40 proportion, coptis root of 4-20 proportion, jujube kernel of 20-40 proportion, Chinese arborvitae kernel of 10-20 proportion, fresh rehmannia root of 10-20 proportion, dried tangerine peel of 5-18 proportion, magnolia officinalis of 5-20 proportion, pinellia of 5-15 proportion, thinleaf milkwort root of 8-20 proportion, dragon bone of 20-40 proportion, oyster of 20-40 proportion, szechwan lovage rhizome of 10-30 proportion, mint of 3-10 proportion, liquorice of 5-15 proportion, vermilion cinnabar of 3-10 proportion, fresh ginger of 1-2 proportion.According to clinical verification, the Chinese traditional medicine combination has the advantages of safety and no side effects, good treating effects, effectiveness rate of over 99 per cent and lasting medicine potency as well as low cost of the adopted components, low curing expense and the invention is convenient for promoting to be used among the patients with the depressive neurosis.
Description
(1) technical field
The invention belongs to field of traditional Chinese, particularly a kind of Chinese medicine composition for the treatment of depressive neurosis also relates to and its production and application simultaneously.
(2) background technology
Depressive neurosis claims the neurosis depression again, be by socio-psychological factors cause a kind of be the neurosis of feature with the low state of persistent mental state, often with anxiety, body sense of discomfort and sleep disorder, the patient has the treatment requirement, do not suppress or spiritual state of an illness symptom but there is tangible mobility, it is not adversely effected to live.This disease is commonly referred to as " dysthymia " in the world.The prevalence of primary disease is 3.1% during nineteen eighty-two.In recent years, along with social competition is fierce further, rhythm of life was accelerated, and prevalence has risen to 5.2%.Account for psychiatric department out-patient's 21.2% according to the psychiatric department report depressive neurosis patient of Huaxi Medical Univ, account for neurosal 70.6%.
The depressive neurosis main clinical manifestation for feel depressed, depressed, pessimistic dejected, with vexed, insomnia etc., belong to motherland's medical science " strongly fragrant disease " category.The cause of disease of strongly fragrant disease is a disorder of affect, makes liver lose bar and reaches functional activity of QI being not smooth, so that depression of liver-QI, shows as spirit depressing, irritable emotion, and uncomfortable in chest heaving a deep sigh, side of body rib expands painful, or irritability is kind cries, and blocks, insomnia uncomfortable in chest with dizziness in the pharynx if any thing.
At present to the treatment of depressive neurosis, first-selected tricyclic antidepressant, as imipramine, doxepin, amitriptyline etc., but the anti-choline side effect of this type of medicine is big, as with symptoms such as xerostomia, urine difficulty, constipation; Also having occurred with the maprotiline at present is the tetracyclic antidepressant of representative, definite effect, side effect seldom, but drug price is quite high, is not suitable for applying.
(3) summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of depressive neurosis, determined curative effect, safe and effective, side effect is little, and expense is low, and patient easily accepts.
The technical solution used in the present invention is as follows:
A kind of Chinese medicine composition for the treatment of depressive neurosis is made by the raw material of following weight portion: Radix Bupleuri 10-20 part Rhizoma Atractylodis Macrocephalae 10-30 part Radix Paeoniae Alba 10-30 part Radix Angelicae Sinensis 8-20 part Poria 20-40 part Rhizoma Coptidis 4-20 part Semen Ziziphi Spinosae (parched) 20-40 part Semen Platycladi 10-20 part Radix Rehmanniae 10-20 part Pericarpium Citri Reticulatae 5-18 part Cortex Magnoliae Officinalis 5-20 part Rhizoma Pinelliae 5-15 part Radix Polygalae 8-20 part Os Draconis 20-40 part Concha Ostreae 20-40 part Rhizoma Chuanxiong 10-30 part Herba Menthae 3-10 part Radix Glycyrrhizae 5-15 part Cinnabaris 3-10 part Rhizoma Zingiberis Recens 1-2 part.
Preferably, described Chinese medicine composition is made by the raw material of following weight portion: Radix Bupleuri 12-17 part Rhizoma Atractylodis Macrocephalae 15-22 part Radix Paeoniae Alba 15-22 part Radix Angelicae Sinensis 10-15 part Poria 25-32 part Rhizoma Coptidis 8-15 part Semen Ziziphi Spinosae (parched) 25-32 part Semen Platycladi 12-18 part Radix Rehmanniae 10-20 part Pericarpium Citri Reticulatae 5-18 part Cortex Magnoliae Officinalis 6-12 part Rhizoma Pinelliae 8-13 part Radix Polygalae 8-15 part Os Draconis 28-35 part Concha Ostreae 28-35 part Rhizoma Chuanxiong 18-25 part Herba Menthae 5-10 part Radix Glycyrrhizae 6-12 part Cinnabaris 3-8 part Rhizoma Zingiberis Recens 1-2 part.
Above-mentioned materials of weight proportions and pharmaceutically acceptable carrier can be prepared into pill, capsule, granule or powder.Further, preferred for preparation becomes capsule.
The Therapeutic Principle has been established in the clinical manifestation of depressive neurosis, and the one, resolving depression, the 2nd, calm the nerves.Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI in the side, regulate the flow of vital energy smooth in, Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, especially the fragrance of Radix Angelicae Sinensis can circulation of qi promoting, flavor is done can emergency, the key medicine of hepatic depression and blood deficiency especially, Rhizoma Atractylodis Macrocephalae Poria invigorating the spleen to clear away damp pathogen is had the right fortuneization, QI and blood is active, is principal agent; The Cinnabaris important city mind of feeling at ease, the Semen Ziziphi Spinosae (parched) mind tranquilizing and the heart calming, Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation, the Radix Polygalae Fructus Alpiniae Oxyphyllae of calming the nerves, Os Draconis, Concha Ostreae tranquillization with heavy prescription, YANG hyperactivity suppressing YIN nourishing are ministerial drug; The pathogenic fire purging of Rhizoma Coptidis bitter cold, clearing heat and relieving fidgetness, Radix Rehmanniae clearing away heat and cooling blood, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Rhizoma Pinelliae alleviating distention in middle-JIAO are regulated the flow of vital energy, and the Rhizoma Chuanxiong blood-activating and qi-promoting falls fire, gas is suitable, blood is alive, and is in the heart tired to separate, and is adjuvant drug; The Rhizoma Zingiberis Recens stomach warming and in, Herba Menthae helps Radix Bupleuri loose stagnation of liver-QI and the heat of life, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is messenger drug.Monarch, minister, help, make that cooperatively interact can dispersing the stagnated live-QI to relieve the stagnation of QI, can regenerate again and calm the nerves, so vexed, insomnia, emotion melancholy can be cured.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of depressive neurosis as mentioned above, and described method is ground into fine powder then for to get each raw material according to weight proportion, again with pharmaceutics on acceptable carrier be prepared into corresponding dosage form.If be prepared into capsule, in No. 2 capsules of the fine powder after pulverizing can being packed into; The preparation of other dosage forms is carried out according to conventional method.
Described Chinese medicine composition can be used to prepare the medicine for the treatment of depressive neurosis with other compositions jointly as effective ingredient.
The present invention has following advantage with respect to prior art:
Described Chinese medicine composition is through clinical verification, and safety has no side effect, good effect, and effective percentage is more than 99%, and the efficacy of a drug is lasting; Adopt the component cost low, medical expense is few, is convenient to promote the use of between the depressive neurosis patient.
(4) specific embodiment:
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited thereto:
Embodiment 1
The resolving stagnation for tranquilization capsule of treatment depressive neurosis: get 2 parts in 7 portions of Rhizoma Zingiberis Recenss of 12 parts of Cinnabaris of 7 portions of Radix Glycyrrhizaes of 22 portions of Herba Menthaes of 32 parts of Rhizoma Chuanxiongs of 32 portions of Concha Ostreaes of 13 parts of Os Draconis of 12 parts of Radix Polygalaes of 10 parts of Rhizoma Pinelliaes of 12 parts of Cortex Magnoliae Officinalis of 16 parts of Pericarpium Citri Reticulataes of 16 parts of Radix Rehmanniae of 32 parts of Semen Platycladi of 12 parts of Semen Ziziphi Spinosae (parched)s of 32 portions of Rhizoma Coptidis of 15 parts of Poria of 22 parts of Radix Angelicae Sinensis of 22 portions of Radix Paeoniae Albas of 16 parts of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri, each raw material is ground into fine powder, the capsule of packing into No. 2 after mixing.
Embodiment 2
Raw material consists of 4 parts in 1 part of Cinnabaris of 6 portions of Rhizoma Zingiberis Recenss of 5 portions of Radix Glycyrrhizaes of 15 portions of Herba Menthaes of 26 parts of Rhizoma Chuanxiongs of 25 portions of Concha Ostreaes of 10 parts of Os Draconis of 7 parts of Radix Polygalaes of 6 parts of Rhizoma Pinelliaes of 8 parts of Cortex Magnoliae Officinalis of 12 parts of Pericarpium Citri Reticulataes of 13 parts of Radix Rehmanniae of 25 parts of Semen Platycladi of 6 parts of Semen Ziziphi Spinosae (parched)s of 22 portions of Rhizoma Coptidis of 10 parts of Poria of 12 parts of Radix Angelicae Sinensis of 12 portions of Radix Paeoniae Albas of 10 parts of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri.
Other are with embodiment 1.
Embodiment 3
Raw material consists of 8 parts in 2 parts of Cinnabaris of 13 portions of Rhizoma Zingiberis Recenss of 8 portions of Radix Glycyrrhizaes of 26 portions of Herba Menthaes of 35 parts of Rhizoma Chuanxiongs of 36 portions of Concha Ostreaes of 15 parts of Os Draconis of 12 parts of Radix Polygalaes of 15 parts of Rhizoma Pinelliaes of 15 parts of Cortex Magnoliae Officinalis of 18 parts of Pericarpium Citri Reticulataes of 18 parts of Radix Rehmanniae of 35 parts of Semen Platycladi of 15 parts of Semen Ziziphi Spinosae (parched)s of 36 portions of Rhizoma Coptidis of 18 parts of Poria of 26 parts of Radix Angelicae Sinensis of 28 portions of Radix Paeoniae Albas of 20 parts of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri, and other are with embodiment 1.
The effect example
Case inclusion criteria: (1) Chinese mental disorder classification and diagnostic criteria (CCMD-3); (2) Hamilton depression scale (HAMD, 24)＞20 minutes; (3) symptom continued for 2 weeks at least; (4) get rid of the depression have due to organic disease, physical disease and the psychoactive drug substance, symptoms such as auditory hallucination, vain hope appear in the patient, differentiate with schizophrenia.
Choose case 14009 examples altogether according to above standard, women 7289 examples, male 6720 examples.Be divided into two groups at random: seminar's 8560 examples, male 4210 examples, women 4350 examples, age 14-75 year; Matched group 5449 examples, male 2510 examples, women 2939 examples, age 14-72 year.Two groups have comparability (P＞0.005).Wherein, the oral present embodiment 1 resolving stagnation for tranquilization capsule of seminar, every day 3 times, each 5.The oral imipramine 75mg of matched group, every day 3 times.
Be for 6 weeks two groups of courses of treatment, adopt HAMD and self rating depressive scale SDS before treatment and after the treatment, to evaluate respectively 1 time in 1,2,4,6 weeks.Evaluate untoward reaction with TESS when treating for 2 weekends, each scale consistency check r=0.89-0.93. of evaluation person subtracts branch rate evaluation curative effect by HAMD, and 〉=75% is recovery from illness, and 〉=74%-25% is that effectively＜25% is invalid.Blood, routine urinalysis before and after the treatment, liver, renal function and electrocardiogram, electroencephalogram are respectively done once.
Effect: two groups be 5 days after onset.Significant change is not seen in the inspection of blood leukocytes counting, hepatic and renal function and electroencephalogram before and after the treatment.Untoward reaction does not appear in seminar; Occur xerostomia, constipation, postural hypotension in the treatment of control group process, the severe patient arrhythmia, disturbance of consciousness occurs.Seminar and matched group curative effect see Table 1:
Table 1
| Group | Recovery from illness | Effectively | Invalid | Total effective rate | The P value |
| Seminar | 7530 | 950 | 80 | 99％ | ＜0.005 |
| Matched group | 4750 | 580 | 119 | 97％ | ＜0.005 |
Seminar's total effective rate 99%, matched group effective percentage 97% adopts t check and X 2 test statistical method, and two groups of contrasts have the significance difference opposite sex (x
2=4.31, P＜0.05).
Claims (6)
1. Chinese medicine composition for the treatment of depressive neurosis is characterized in that being made by the raw material of following weight portion:
Radix Bupleuri 10-20 part Rhizoma Atractylodis Macrocephalae 10-30 part Radix Paeoniae Alba 10-30 part Radix Angelicae Sinensis 8-20 part Poria 20-40 part Rhizoma Coptidis 4-20 part Semen Ziziphi Spinosae (parched) 20-40 part Semen Platycladi 10-20 part Radix Rehmanniae 10-20 part Pericarpium Citri Reticulatae 5-18 part Cortex Magnoliae Officinalis 5-20 part Rhizoma Pinelliae 5-15 part Radix Polygalae 8-20 part Os Draconis 20-40 part Concha Ostreae 20-40 part Rhizoma Chuanxiong 10-30 part Herba Menthae 3-10 part Radix Glycyrrhizae 5-15 part Cinnabaris 3-10 part Rhizoma Zingiberis Recens 1-2 part.
2. the Chinese medicine composition of treatment depressive neurosis as claimed in claim 1 is characterized in that being made by the raw material of following weight portion:
Radix Bupleuri 12-17 part Rhizoma Atractylodis Macrocephalae 15-22 part Radix Paeoniae Alba 15-22 part Radix Angelicae Sinensis 10-15 part Poria 25-32 part Rhizoma Coptidis 8-15 part Semen Ziziphi Spinosae (parched) 25-32 part Semen Platycladi 12-18 part Radix Rehmanniae 10-20 part Pericarpium Citri Reticulatae 5-18 part Cortex Magnoliae Officinalis 6-12 part Rhizoma Pinelliae 8-13 part Radix Polygalae 8-15 part Os Draconis 28-35 part Concha Ostreae 28-35 part Rhizoma Chuanxiong 18-25 part Herba Menthae 5-10 part Radix Glycyrrhizae 6-12 part Cinnabaris 3-8 part Rhizoma Zingiberis Recens 1-2 part.
3. the Chinese medicine composition of treatment depressive neurosis as claimed in claim 1 or 2 is characterized in that described raw material and pharmaceutically acceptable carrier make pill, capsule, granule, powder.
4. the Chinese medicine composition of treatment depressive neurosis as claimed in claim 3 is characterized in that described Chinese medicine composition is prepared into capsule.
5. the method for the Chinese medicine composition of depressive neurosis is treated in preparation as claimed in claim 1 or 2, it is characterized in that described method for to get each raw material, become pill, capsule, granule or powder with pharmaceutically acceptable preparing carriers after being ground into fine powder according to proportioning.
6. treat of the application of the Chinese medicine composition of depressive neurosis as claimed in claim 1 or 2 as the effective ingredient of the medicine of treatment depressive neurosis.
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| CN101433645B (en) * | 2008-09-09 | 2011-06-01 | 中国人民解放军第二军医大学 | Chinese medicine preparation for resisting depression and stress-induced mental disorder, and preparation method thereof |
| CN102370727A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Compound Chinese medicinal preparation for treating depression and preparation method thereof |
| CN102895376A (en) * | 2012-11-08 | 2013-01-30 | 蒿崑 | Chinese medicinal mixture for assisting in nerve soothing and pulse stabilization of computed tomography angiography (CTA) examination of coronary arteries |
| CN103127481A (en) * | 2012-12-09 | 2013-06-05 | 延安大学 | Drug curing depressive disorder |
| CN103405637A (en) * | 2013-08-30 | 2013-11-27 | 董中影 | Drug for treating neurosis and preparation method thereof |
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| CN104491513A (en) * | 2014-12-05 | 2015-04-08 | 王婷婷 | Traditional Chinese medicine composition for treating somatoform disorders |
| CN106039238A (en) * | 2016-08-10 | 2016-10-26 | 单团结 | Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof |
| CN106581588A (en) * | 2017-01-29 | 2017-04-26 | 毛华养 | Medicine for treating depressive neurosis |
| CN108236665A (en) * | 2016-12-22 | 2018-07-03 | 邢德忠 | A kind of Chinese medicinal formulae for treating depression |
| CN110013539A (en) * | 2019-04-22 | 2019-07-16 | 沈阳国和医疗科技有限公司 | A kind of pharmaceutical formulation for treating insomnia |
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| CN100389780C (en) * | 2005-07-01 | 2008-05-28 | 武汉普百康科技发展有限公司 | Traditional Chinese medicine for treating depressive disorders, and its prepn. method |
| CN100379436C (en) * | 2006-01-23 | 2008-04-09 | 首都医科大学宣武医院 | Pharmaceutical composition for treating depression, preparation method and application thereof |
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- 2007-12-20 CN CN2007103000164A patent/CN101204575B/en not_active Expired - Fee Related
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| CN101433645B (en) * | 2008-09-09 | 2011-06-01 | 中国人民解放军第二军医大学 | Chinese medicine preparation for resisting depression and stress-induced mental disorder, and preparation method thereof |
| CN102370727B (en) * | 2011-11-17 | 2016-05-25 | 中国中医科学院中医临床基础医学研究所 | Compound Chinese medicinal preparation of a kind of Cure of depression and preparation method thereof |
| CN102370727A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Compound Chinese medicinal preparation for treating depression and preparation method thereof |
| CN102895376A (en) * | 2012-11-08 | 2013-01-30 | 蒿崑 | Chinese medicinal mixture for assisting in nerve soothing and pulse stabilization of computed tomography angiography (CTA) examination of coronary arteries |
| CN103127481A (en) * | 2012-12-09 | 2013-06-05 | 延安大学 | Drug curing depressive disorder |
| CN103127481B (en) * | 2012-12-09 | 2014-07-09 | 延安大学 | Drug curing depressive disorder |
| CN103405637A (en) * | 2013-08-30 | 2013-11-27 | 董中影 | Drug for treating neurosis and preparation method thereof |
| CN104435798A (en) * | 2014-10-29 | 2015-03-25 | 济南方宇文化传媒有限公司 | Traditional Chinese medicine preparation for improving neurasthenia and preparation method thereof |
| CN104491513A (en) * | 2014-12-05 | 2015-04-08 | 王婷婷 | Traditional Chinese medicine composition for treating somatoform disorders |
| CN106039238A (en) * | 2016-08-10 | 2016-10-26 | 单团结 | Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof |
| CN108236665A (en) * | 2016-12-22 | 2018-07-03 | 邢德忠 | A kind of Chinese medicinal formulae for treating depression |
| CN106581588A (en) * | 2017-01-29 | 2017-04-26 | 毛华养 | Medicine for treating depressive neurosis |
| CN110013539A (en) * | 2019-04-22 | 2019-07-16 | 沈阳国和医疗科技有限公司 | A kind of pharmaceutical formulation for treating insomnia |
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| CN111671868B (en) * | 2020-05-11 | 2021-09-10 | 首都医科大学附属北京中医医院 | Novel traditional Chinese medicine composition for treating mild symptoms, namely coronavirus pneumonia and insomnia |
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