CN106039238A - Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof - Google Patents

Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof Download PDF

Info

Publication number
CN106039238A
CN106039238A CN201610653281.XA CN201610653281A CN106039238A CN 106039238 A CN106039238 A CN 106039238A CN 201610653281 A CN201610653281 A CN 201610653281A CN 106039238 A CN106039238 A CN 106039238A
Authority
CN
China
Prior art keywords
parts
radix
depressive neurosis
chinese medicine
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610653281.XA
Other languages
Chinese (zh)
Inventor
单团结
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610653281.XA priority Critical patent/CN106039238A/en
Publication of CN106039238A publication Critical patent/CN106039238A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/84Valerianaceae (Valerian family), e.g. valerian
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicinal composition for treating depressive neurosis. The composition is prepared from, by weight, 10-15 parts of Medulla Junci, 20-25 parts of Cortex Albiziae, 15-20 parts of Rhizoma Atractylodis Macrocephalae, 13-18 parts of Radix Curcumae Aromaticae, 13-18 parts of radix bupleuri, 15-20 parts of Chinese magnoliavine, 15-20 parts of Poria cocos, 15-20 parts of Fructus Gardeniae, 10-15 parts of white peony root, 10-15 parts of Valeriana officinalis L. and 15-20 parts of Folium Eucommiae. The invention also discloses a preparation method of the composition, and an application of the composition in depressive neurosis treatment medicines as an effective component. All raw material traditional Chinese medicines complement each other, and cooperate to realize the efficacy of soothing the liver and resolving depression, invigorating spleen and benefiting qi, tonifying liver and kidney, and calming heart and tranquilizing mind, so the composition has a definite treatment effect on the depressive neurosis, and has the advantages of substantial treatment effect, high safety, no toxic or side effects, realization of the effective rate reaching 99.4%, and very good promotion and use values.

Description

A kind of Chinese medicine composition treating depressive neurosis and its preparation method and application
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating depressive neurosis and preparation side thereof Method and application.
Background technology
Depressive neurosis, also known as dysthymic disorder, is that a kind of lasting emotion caused due to socio-psychological factors presses down Strongly fragrant, its lesser extent, the course of disease is relatively delayed.Have the feature that (1) has lasting depressed, dejected, constrain, with Jiao Consider, Somatic discomfort and sleep disorder.(2) without the neurosal feature of major depressive, as sluggish, unreal without obvious psychomotor activity Circadian change caused by feel, vain hope and the change of abiology aspect, early awakening insomnia, losing weight without obvious cause Deng.(3) contact with surrounding well, daily work, learn and life Non Apparent Abnormality.(4) there is insight, can actively seek medical advice. Common psychosocial factor has man and wife to quarrel, divorced, the difference of relatives, unexpected disability, operational difficulties, interpersonal difficulty, Fail.Primary disease women is common, and many onsets are in juvenile era.The Most patients course of disease is longer, prognosis bona, especially spirit Factor is single, without depressed personality person.But such as Relapse rate, often fluctuate along with the impact of Nervous and Mental Factors, there is depressed personality barrier The person of hindering, the course of disease relatively delays, and prognosis is not good enough.Primary disease treatment needs psychotherapy and Drug therapy to carry out simultaneously, can obtain good result. At present, depressive neurosis is treated frequently with tricyclic antidepressants amitriptyline, chlorine the third miaow prolixity etc. in psychiatric department, although effective Hurry up, but its anticholinergic side effects (such as dizziness, postural hypotension, xerostomia, dysuria etc.) and induced cardiotoxicity are (such as the heart Dynamic overrun, conduction block etc.) make patient not be easily accepted by, or more after end-of-dose failure, obstinate, affect the social merit of patient for a long time Energy and quality of life.
Summary of the invention
For the deficiencies in the prior art, the invention provides the Chinese drug-treated group of the treatment depressive neurosis of a kind of determined curative effect Compound and its preparation method and application.
For realizing object above, the present invention is achieved by the following technical programs:
A kind of Chinese medicine composition treating depressive neurosis, is made up of the raw material of following weight portion: Medulla Junci 10-15 Part, Cortex Albiziae 20-25 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Curcumae 13-18 part, Radix Bupleuri 13-18 part, Fructus Schisandrae Chinensis 15-20 part, Poria 15-20 Part, Fructus Gardeniae 15-20 part, Radix Paeoniae Alba 10-15 part, Rhizoma et radix valerianae 10-15 part, Folium Eucommiae 15-20 part.
Preferably, it is made up of the raw material of following weight portion: Medulla Junci 12 parts, Cortex Albiziae 21 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Radix Curcumae 15 Part, Radix Bupleuri 15 parts, Fructus Schisandrae Chinensis 18 parts, 20 parts of Poria, Fructus Gardeniae 17 parts, the Radix Paeoniae Alba 14 parts, Rhizoma et radix valerianae 12 parts, Folium Eucommiae 16 parts.
The preparation method of the Chinese medicine composition for the treatment of depressive neurosis, comprises the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collects Distillate, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct extraction 2 Secondary, each 1h, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux extraction 2 times, often Secondary 1h, filters, obtains alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give leaching Cream, is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as corresponding pharmaceutical dosage form.
Preferably, described dosage form is tablet, granule, capsule or pill.
Treatment depressive neurosis Chinese medicine composition as treatment depressive neurosis medicine effective ingredient should With.
In the present invention, effect of each raw material Chinese medicine is as follows:
Medulla Junci: cold nature, sweet in the mouth, light, GUIXIN warp, lung meridian, small intestine meridian, clearing away heart-fire, diuresis are wet with controlling pyretic stranguria, water The edema inside stopped, dysuria, oedema due to nephritis, dysphoria and insomnia, nocturnal fretfulness in infants etc..
Cortex Albiziae: property put down, sweet in the mouth, GUIXIN warp, Liver Channel, lung meridian, resolving stagnation for tranquilization, promoting blood circulation and detumescence, modern times with control irritability, Melancholy insomnia.
The Rhizoma Atractylodis Macrocephalae: warm in nature, sweet in the mouth, hardship, return spleen channel, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic.
Radix Curcumae: cold in nature, acrid in the mouth, hardship, return Liver Channel, heart channel, lung meridian, promoting blood circulation and stopping pain, circulation of qi promoting scabies, heart fire-clearing upset-relieving, function of gallbladder promoting to move back Yellow.
Radix Bupleuri: cold nature, bitter in the mouth, return Liver Channel, gallbladder meridian, lung meridian, reconciling superficies and interior, soothing the liver yang invigorating, pharmacological testing proves, has Antiinflammatory, antipyretic, calm, analgesia, antitussive and anticonvulsant action;Hepatic injury can be alleviated and promote bile secretion.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung meridian, heart channel, kidney channel, restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Poria: property is put down, sweet in the mouth, light, GUIXIN warp, lung meridian, spleen channel, kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Fructus Gardeniae: cold in nature, bitter in the mouth, GUIXIN warp, lung meridian, tri-jiao channel, pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, with controlling epidemic febrile disease Heat stagnation ambition, vexed, gloomy, restlessness is peaceful, sleep disorder.
The Radix Paeoniae Alba: cold nature, bitter in the mouth, acid, return Liver Channel, spleen channel, suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma et radix valerianae: property is put down, bitter in the mouth is micro-sweet, GUIXIN warp, Liver Channel, has effect of mind tranquilizing and the heart calming.
Folium Eucommiae: warm in nature, taste is micro-pungent.Return Liver Channel, kidney channel, invigorating the liver and kidney, bone and muscle strengthening.
The method have the benefit that in the present invention, each raw material Chinese medicine complements each other, synergism, play dispersing the stagnated live-QI to relieve the stagnation of QI, spleen invigorating altogether QI invigorating, liver and kidney tonifying, effect of mind tranquilizing and the heart calming, there is definite curative effect for depressive neurosis, and evident in efficacy, safety is without secondary Effect, effective percentage reaches 99.4%, has good popularizing value.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one Divide embodiment rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making The every other embodiment obtained under creative work premise, broadly falls into the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine composition treating depressive neurosis, is made up of the raw material of following weight portion: Medulla Junci 12 parts, conjunction Joyous skin 21 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Radix Curcumae 15 parts, Radix Bupleuri 15 parts, Fructus Schisandrae Chinensis 18 parts, 20 parts of Poria, Fructus Gardeniae 17 parts, the Radix Paeoniae Alba 14 parts, figured silk fabrics Grass 12 parts, Folium Eucommiae 16 parts.
The preparation method of the Chinese medicine composition for the treatment of depressive neurosis, comprises the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collects Distillate, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct extraction 2 Secondary, each 1h, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux extraction 2 times, often Secondary 1h, filters, obtains alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give leaching Cream, is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as tablet.
Embodiment 2:
A kind of Chinese medicine composition treating depressive neurosis, is made up of the raw material of following weight portion: Medulla Junci 13 parts, conjunction Joyous skin 24 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Radix Curcumae 16 parts, Radix Bupleuri 16 parts, Fructus Schisandrae Chinensis 20 parts, 18 parts of Poria, Fructus Gardeniae 18 parts, the Radix Paeoniae Alba 12 parts, figured silk fabrics Grass 13 parts, Folium Eucommiae 17 parts.
The preparation method of the Chinese medicine composition for the treatment of depressive neurosis, comprises the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collects Distillate, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct extraction 2 Secondary, each 1h, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux extraction 2 times, often Secondary 1h, filters, obtains alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give leaching Cream, is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as granule.
Embodiment 3:
A kind of Chinese medicine composition treating depressive neurosis, is made up of the raw material of following weight portion: Medulla Junci 14 parts, conjunction Joyous skin 22 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Radix Curcumae 15 parts, Radix Bupleuri 16 parts, Fructus Schisandrae Chinensis 17 parts, 18 parts of Poria, Fructus Gardeniae 16 parts, the Radix Paeoniae Alba 13 parts, figured silk fabrics Grass 10 parts, Folium Eucommiae 15 parts.
The preparation method of the Chinese medicine composition for the treatment of depressive neurosis, comprises the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collects Distillate, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct extraction 2 Secondary, each 1h, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux extraction 2 times, often Secondary 1h, filters, obtains alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give leaching Cream, is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as capsule.
Embodiment 4:
A kind of Chinese medicine composition treating depressive neurosis, is made up of the raw material of following weight portion: Medulla Junci 10 parts, conjunction Joyous skin 25 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Curcumae 18 parts, Radix Bupleuri 13 parts, Fructus Schisandrae Chinensis 20 parts, 15 parts of Poria, Fructus Gardeniae 20 parts, the Radix Paeoniae Alba 10 parts, figured silk fabrics Grass 15 parts, Folium Eucommiae 15 parts.
The preparation method of the Chinese medicine composition for the treatment of depressive neurosis, comprises the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collects Distillate, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct extraction 2 Secondary, each 1h, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux extraction 2 times, often Secondary 1h, filters, obtains alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give leaching Cream, is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as pill.
Embodiment 5:
A kind of Chinese medicine composition treating depressive neurosis, is made up of the raw material of following weight portion: Medulla Junci 15 parts, conjunction Joyous skin 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Curcumae 13 parts, Radix Bupleuri 18 parts, Fructus Schisandrae Chinensis 15 parts, 20 parts of Poria, Fructus Gardeniae 15 parts, the Radix Paeoniae Alba 15 parts, figured silk fabrics Grass 10 parts, Folium Eucommiae 20 parts.
The preparation method of the Chinese medicine composition for the treatment of depressive neurosis, comprises the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collects Distillate, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct extraction 2 Secondary, each 1h, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux extraction 2 times, often Secondary 1h, filters, obtains alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give leaching Cream, is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as tablet.
Clinical practice
Case selection: select Factors of Depressive Patients 340 example made a definite diagnosis, wherein male 152 example, women 188 example, age In 14-65 year, the mean age is 26 years old, is randomly divided into 2 groups, experimental group and matched group, often organizes each 170 examples, male 76 example, women 94 examples, the equal not statistically significant of difference (P < 0.05) such as two groups of sexes, age, the state of an illness, courses of disease, there is comparability.
1, diagnostic criteria: 1. Chinese Spirit Obstacles classification and diagnostic criteria (CCMD-3);2. Hamilton depression scale (HAMD, 24) > 20 points;3. symptom at least continues 2 weeks;4. get rid of and have organic disease, physical disease and psychoactive drug substance Caused depression, there is the symptom such as auditory hallucination, vain hope, differentiates with schizophrenia in patient.
2, Therapeutic Method: experimental group be administered orally the embodiment of the present invention 1 preparation Chinese medicinal tablet, 2g/ sheet, three times a day, each 2 Grain;Matched group is administered orally imipramine 75mg, and three times a day, two groups for the treatment of cycle were for 4 courses for the treatment of, within 10 days, were 1 course for the treatment of.
Outcome measure: use HAMD and self rating depressive scale SDS before the treatment and after treatment each course for the treatment of terminate after respectively Evaluate 1 time, after treating for 2 courses for the treatment of, evaluate untoward reaction with TESS, evaluation person each scale consistency check r=0.89-0.93;Press HAMD deduction rate evaluation curative effect, >=75% is recovery from illness, and >=74%-25% is that effectively < 25% is invalid;Blood, urine before and after treatment Routine, Liver and kidney function and electrocardiogram, electroencephalogram respectively do once.
4, therapeutic effect: 150 examples of fully recovering in experimental group 170 example, effective 19 examples, invalid 1 example, total effective rate reaches 99.4%; Matched group is fully recovered 138 examples, effective 24 examples, invalid 8 examples, total effective rate 95.3%, it can be seen that experimental group cure rate, the most effective Rate is significantly better than that matched group.Before and after treatment, the inspection of Leukocyte Counts, hepatic and renal function and electroencephalogram has no significant change, real Test group and untoward reaction does not occurs;Xerostomia, constipation, postural hypotension occur during treatment of control group, severe patient arrhythmia, Disturbance of consciousness occurs.
Above example only in order to technical scheme to be described, is not intended to limit;Although with reference to previous embodiment The present invention is described in detail, it will be understood by those within the art that: it still can be to aforementioned each enforcement Technical scheme described in example is modified, or wherein portion of techniques feature is carried out equivalent;And these amendment or Replace, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.

Claims (5)

1. the Chinese medicine composition treating depressive neurosis, it is characterised in that be made up of the raw material of following weight portion: wick Grass 10-15 part, Cortex Albiziae 20-25 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Curcumae 13-18 part, Radix Bupleuri 13-18 part, Fructus Schisandrae Chinensis 15-20 part, Fu Siberian cocklebur 15-20 part, Fructus Gardeniae 15-20 part, Radix Paeoniae Alba 10-15 part, Rhizoma et radix valerianae 10-15 part, Folium Eucommiae 15-20 part.
2. the Chinese medicine composition treating depressive neurosis as claimed in claim 1, it is characterised in that by following weight portion Raw material is made: Medulla Junci 12 parts, Cortex Albiziae 21 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Radix Curcumae 15 parts, Radix Bupleuri 15 parts, Fructus Schisandrae Chinensis 18 parts, Poria 20 Part, Fructus Gardeniae 17 parts, the Radix Paeoniae Alba 14 parts, Rhizoma et radix valerianae 12 parts, Folium Eucommiae 16 parts.
3. the preparation method of the Chinese medicine composition for the treatment of depressive neurosis as claimed in claim 1 or 2, it is characterised in that Comprise the following steps:
1) Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Rhizoma et radix valerianae are taken, mixing, it is placed in volatile oil extractor, soaks, decompression distillation 1h, collection evaporates Liquid, second distillation, ether extracts, and is dried, obtains volatile oil, Aqueous extracts and filtering residue standby;
2) by Medulla Junci, Folium Eucommiae, Radix Bupleuri, Poria and step 1) in filtering residue mixing, add 8 times amount water, decoct and extract 2 times, 1h every time, filters, discards medicinal residues, obtain Aqueous extracts;
3) Cortex Albiziae, Fructus Schisandrae Chinensis, Fructus Gardeniae, the Radix Paeoniae Alba are taken, mixing, add 8 times amount 70% alcohol heating reflux and extract 2 times, each 1h, Filter, obtain alcohol extract;
4) combining step 1) Aqueous extracts and volatile oil, step 2) in Aqueous extracts, step 3) alcohol extract, be concentrated to give extractum, It is dried, is ground into medicated powder;
5) in medicated powder, add pharmaceutically acceptable carrier, be prepared as corresponding pharmaceutical dosage form.
4. the preparation method of the Chinese medicine composition for the treatment of depressive neurosis as claimed in claim 3, it is characterised in that described Dosage form is tablet, granule, capsule or pill.
5. treat the Chinese medicine composition medicine as treatment depressive neurosis of depressive neurosis as claimed in claim 1 or 2 The application of the effective ingredient of thing.
CN201610653281.XA 2016-08-10 2016-08-10 Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof Pending CN106039238A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610653281.XA CN106039238A (en) 2016-08-10 2016-08-10 Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610653281.XA CN106039238A (en) 2016-08-10 2016-08-10 Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN106039238A true CN106039238A (en) 2016-10-26

Family

ID=57480368

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610653281.XA Pending CN106039238A (en) 2016-08-10 2016-08-10 Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN106039238A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106581238A (en) * 2017-01-02 2017-04-26 佛山市腾瑞医药科技有限公司 Traditional Chinese medicine composition for relaxing bowels and preparation method of traditional Chinese medicine composition
CN106581588A (en) * 2017-01-29 2017-04-26 毛华养 Medicine for treating depressive neurosis
CN107080785A (en) * 2017-04-07 2017-08-22 云南龙发制药股份有限公司 A kind of jatamans valeriana rhizome volatile oil antiseptic inclusion compound and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579461A (en) * 2003-08-07 2005-02-16 于水 Anti-depression traditional medicinal composition and its preparation method
CN101204575A (en) * 2007-12-20 2008-06-25 董建国 Chinese traditional medicine composite for depressive neurosis, preparation method and application thereof
CN103285334A (en) * 2013-06-25 2013-09-11 单翠红 Prescription for treatment of depressive neurosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579461A (en) * 2003-08-07 2005-02-16 于水 Anti-depression traditional medicinal composition and its preparation method
CN101204575A (en) * 2007-12-20 2008-06-25 董建国 Chinese traditional medicine composite for depressive neurosis, preparation method and application thereof
CN103285334A (en) * 2013-06-25 2013-09-11 单翠红 Prescription for treatment of depressive neurosis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106581238A (en) * 2017-01-02 2017-04-26 佛山市腾瑞医药科技有限公司 Traditional Chinese medicine composition for relaxing bowels and preparation method of traditional Chinese medicine composition
CN106581588A (en) * 2017-01-29 2017-04-26 毛华养 Medicine for treating depressive neurosis
CN107080785A (en) * 2017-04-07 2017-08-22 云南龙发制药股份有限公司 A kind of jatamans valeriana rhizome volatile oil antiseptic inclusion compound and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102670776B (en) Traditional Chinese medicine composition for curing rheumatism
CN101757313A (en) Liquid medicine with acupuncture effect
CN106039238A (en) Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof
CN104274725A (en) Traditional Chinese medicinal composition for treating depression and insomnia as well as preparation method and application thereof
CN103816402A (en) Traditional Chinese medicine composition for treating liver wind agitation
CN104491695A (en) Pharmaceutical composition for treating chloasma
CN109966413A (en) It is a kind of for treating the traditional Chinese medicine for external application of the peripheral neuropathy of caused by chemotherapeutic medicines
CN101966298B (en) Traditional Chinese medicine for treating wind-cold numbness
CN104000890B (en) Traditional Chinese medicine for harmonizing liver and spleen, dispelling wind and eliminating dampness and nourishing blood and stopping throat pains
CN101112533B (en) A Chinese medicinal composition for treating and preventing gout, and its preparation method
CN100515486C (en) Medicine for treating senile dementia and its preparing process
CN101664518B (en) Moist bath lotion composition, preparation method and application in preparing pharmaceuticals and health products for treating YIN-blood deficiency fatigue syndrome or adiposity
CN103830482A (en) Traditional Chinese medicine preparation for treating stroke and preparation method thereof
CN101195003B (en) Proprietary Chinese medicine for treating apoplexy and sequela
CN102784234A (en) Traditional Chinese medicine composition for treating chronic urticaria
CN104606650A (en) Traditional Chinese medicine composition treating insomnia
CN110339323A (en) A kind of Chinese medicine composition and its preparation method and application for treating bradycardia
CN103736027A (en) Traditional Chinese medicine composition for treating insomnia
CN114504635B (en) Chinese patent medicine for treating apoplexy sequela
CN103341015B (en) Medicine for treating three-highs and preparation method thereof
CN103751488B (en) A kind of medicine for the treatment of high-sensitivity condition after neurosurgery operation
CN106729198A (en) It is a kind of to treat Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof
CN101279069A (en) Medicament composite for dredging channels and collaterals, and promoting blood-circulation and removing blood stasis, and method of preparing the same
CN106581553A (en) Lozenge utilizing biological extract to treat cardio-cerebrovascular diseases and preparation method thereof
CN105497783A (en) Application of traditional Chinese medicine preparation to preparing drug for treating qi stagnation and blood stasis type chloasma

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20161026

RJ01 Rejection of invention patent application after publication