CN106729198A - It is a kind of to treat Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to the field of Chinese medicines, and in particular to a kind of to treat Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof, the Chinese medicine preparation of the treatment pesticide poisoning sequela is made up of the bulk drug of following weight portion：15 20 parts of Radix Glycyrrhizae, 20 25 parts of chrysanthemum, 8 15 parts of dried orange peel, 8 12 parts of Ligusticum wallichii, 10 15 parts of Ramulus Taxilli, 6 12 parts of Chinese yam, 8 12 parts of the bighead atractylodes rhizome, 12 16 parts of Radix Angelicae Sinensis, 6 10 parts of Semen Lablab Album, 20 30 parts of smilax, 48 parts of lalang grass rhizome, yellow 5 10 parts of the rose of Sharon, 12 18 parts of caulis bambusae in taenian, 48 parts of Herba Kalimeridis, 5 10 parts of the Radix Astragali, 8 15 parts of pseudo-ginseng, 6 10 parts of dateplum persimmon, 8 15 parts of the bark of eucommia, its preparation method mainly includes：(1) dry, crush and weigh；(2) extraction and treatment of volatile oil；(3) extract；(4) preparation, Chinese medicine preparation of the present invention can accelerate toxin to drain, for pesticide poisoning sequela such as indigestion, do not feel like eating, have no peace of mind, mental depression etc. has special efficacy, Chinese medicine preparation of the present invention is convenient to take and has no toxic side effect, evident in efficacy to treatment pesticide poisoning sequela.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine preparation for treating pesticide poisoning sequela and its preparation side
Method.
Background technology
At present, China's insecticide consumption rank forefront four be organophosphor, organochlorine, Spanon and carbamates, especially
It is the most universal with organic phosphates poisoning, so pesticide poisoning clinically is more with organophosphorus insecticide poisoning.Lost after pesticide poisoning
Disease refers to pesticide poisoning after emergency call salving, and the sequelae shape that survivor's body is present shows skin, respiratory tract, alimentary canal more
Deng.
Pesticide poisoning belongs to the categories such as traditional Chinese medicine " halitosis ", " nausea ", " vomiting ", " sound of vomiting ".Ancient prescription traditional Chinese medical science difficult disease research
Institute TCM Major personage represents：Pesticide poisoning etiology and pathogenesis are mainly shown as that upward steaming of stomach-heat, exopathogen violate stomach, eating and drinking without temperance tripartite
Face, the weight of pesticide poisoning sequela is closely related with toxic dose, concentration and time.Ancient prescription TCM Major personage point out：Agriculture
Medicine poisoning sequelae is primarily referred to as organic phosphorus pesticide poisoning sequelae, usually by the symptom caused in terms of nervous system, specifically
The sensation reduction at sign such as certain position of body or missing and paralysis etc., it is evil that Syndrome Differentiation of Traditional Chinese Medicine can be divided into pesticide poisoning sequela
Resistance channels and collaterals type and pesticide poisoning sequela due to weakness of spleen and stomach etc..Pesticide poisoning can damage liver and gall renal function, and being allowed to can not be normal
Edera Extract, so as to cause diffusivity brain damage, the glucose recovery that sequelae occurs in organic phosphorus pesticide poisoning is very slow.Syndrome Differentiation of Chinese Medicine
Card classification therapy pesticide poisoning sequela requirement integral syndrome differentiation opinion is controlled, therefore pesticide poisoning sequela is controlled from the angle of the traditional Chinese medical science
Treatment is one of effective method.
The content of the invention
Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof, the Chinese medicine preparation are treated the invention provides a kind of
It is convenient to take and have no toxic side effect, it is evident in efficacy to treatment pesticide poisoning sequela.
To realize object above, the present invention is achieved by the following technical programs：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：Radix Glycyrrhizae 15-20
Part, chrysanthemum 20-25 parts, dried orange peel 8-15 parts, Ligusticum wallichii 8-12 parts, Ramulus Taxilli 10-15 parts, Chinese yam 6-12 parts, bighead atractylodes rhizome 8-12 parts, Radix Angelicae Sinensis
12-16 parts, Semen Lablab Album 6-10 parts, smilax 20-30 parts, lalang grass rhizome 4-8 parts, yellow 5-10 parts of the rose of Sharon, caulis bambusae in taenian 12-18 parts, Herba Kalimeridis 4-8
Part, Radix Astragali 5-10 parts, pseudo-ginseng 8-15 parts, dateplum persimmon 6-10 parts, bark of eucommia 8-15 parts.
Preferably, the Chinese medicine preparation of the treatment pesticide poisoning sequela is made up of the bulk drug of following weight portion：Radix Glycyrrhizae
18 parts, 22 parts of chrysanthemum, 12 parts of dried orange peel, 10 parts of Ligusticum wallichii, 12 parts of Ramulus Taxilli, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome, 14 parts of Radix Angelicae Sinensis, Semen Lablab Album 8
Part, 25 parts of smilax, 6 parts of lalang grass rhizome, yellow 8 parts of the rose of Sharon, 15 parts of caulis bambusae in taenian, 6 parts of Herba Kalimeridis, 7 parts of the Radix Astragali, 12 parts of pseudo-ginseng, 7 parts of dateplum persimmon, Du
Secondary 12 parts.
The preparation method of the Chinese medicine preparation of pesticide poisoning sequela is treated, is comprised the following steps：
(1) dry, crush and weigh：Crushed after each bulk drug is dried into 3-5h at 55-65 DEG C respectively, crossed 40-
80 mesh sieves, weigh the crushed material of each bulk drug in proportion；
(2) extraction and treatment of volatile oil：Add its gross mass after the crushed material of chrysanthemum, dried orange peel, the bighead atractylodes rhizome and Radix Angelicae Sinensis is mixed
After 8-12 times is measured saturated sodium-chloride water solution immersion 1-2h, using extraction by steam distillation volatile oil, just distillate is collected, to first
Distillate carries out secondary steam distillation, obtains rectifying liquid, is extracted with ether, anhydrous sodium sulfate drying, is concentrated under reduced pressure, and obtains volatile oil,
The dregs of a decoction and fried liquid retain standby, then by volatile oil beta-cyclodextrin inclusion compound, are made inclusion particle；
(3) extract：By Radix Glycyrrhizae, Ligusticum wallichii, Ramulus Taxilli, Chinese yam, Semen Lablab Album, smilax, lalang grass rhizome, the yellow rose of Sharon, caulis bambusae in taenian, Herba Kalimeridis,
The water immersion 20-40min for adding 9-11 times of its gross mass to measure after the Radix Astragali, pseudo-ginseng, dateplum persimmon, the crushed material mixing of the bark of eucommia, adds step
Suddenly the dregs of a decoction and fried liquid in (2), are extracted 2-3 times with ultrasonic extractor, and each 30-45min is filtered, aqueous extract afterwards
Through concentrated under reduced pressure, dry water extract；
(4) preparation：Step (2) gained inclusion particle and step (3) gained water extract are well mixed, auxiliary material is added,
Granulation is tabletted, is coated, and obtains final product.
Preferably, the mesh number of sieving is 60 mesh in the step (1).
Preferably, anhydrous sodium sulfate drying 6-8h is used in the step (2).
Preferably, the drying mode in the step (3) is freeze-drying or spray drying.
In the present invention, effect of each Chinese medicine material medicinal material is as follows：
Radix Glycyrrhizae：It is sweet, flat, returns spleen, stomach, lung channel.With nourishing the stomach, enrich blood, invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, rush down
The effects such as fire, removing toxic substances, coordinating the drug actions of a prescription.
Chrysanthemum：Bitter, tepor, return lung, Liver Channel, the effects such as with dispelling wind, heat-clearing, removing toxic substances, diuresis, treating stranguria, invigorating the spleen and stomach.
Dried orange peel：Bitter, temperature, returns spleen, stomach, lung channel, with heat-clearing, removing toxic substances, diuresis, treating stranguria, invigorating the spleen, tune, qi-regulating the effects such as,
Suitable for diseases such as weakness of the spleen and the stomach, diet reduction, indigestion, diarrheas.
Ligusticum wallichii：It is pungent, temperature, Return liver, gallbladder channel.Former times people meaning Ligusticum wallichii be blood in gas medicine, nearly say its residence it is pungent dissipate, Xie Yu, it is sensible, only
The functions such as pain.
Ramulus Taxilli：It is bitter, sweet, flat, enter liver and kidney channel.The effects such as with filling liver kidney, strengthening the bones and muscles, except rheumatism, degrading the channel, beneficial blood,
Cure mainly that soreness of waist and knee joint, muscles and bones impotence be weak, hemiplegia, wind-cold-dampness arthralgia lamp disease.
Chinese yam：It is sweet, flat, nontoxic, returns spleen, lung, kidney channel, with nourish it is strong, aid digestion, hold back abnormal sweating, antidiarrheal the effect of, it is main
Insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes is controlled the disease such as to quench one's thirst.
The bighead atractylodes rhizome：It is bitter, sweet, temperature, returns spleen, stomach.It is strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive.For spleen eating less, abdominal distension
Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration.
Radix Angelicae Sinensis：Sweet, pungent, temperature, Return liver, the heart, the spleen channel.With enriching blood, invigorate blood circulation, moisturize laxation the effects such as.Cure mainly all cards of the deficiency of blood,
Abdominal mass knot is poly-, the disease such as again after asthenia cold abdominalgia, Impotence numbness, numbness, intestines are dry and shit is difficult, dysentery characterized by blood in the stool.
Semen Lablab Album：It is sweet, tepor, returns spleen, stomach.Invigorating the spleen for eliminating dampness, and in relieve summer heat.For treat it is weakness of the spleen and the stomach, poor appetite,
The diseases such as diarrhea, summer-heat and damp vomiting and diarrhoea, vexed abdominal distension.
Smilax：It is sweet, light, flat, Return liver, stomach.There is removing toxic substances, dehumidifying, easing joint movement.
Lalang grass rhizome：It is sweet, it is bitter, tremble with fear, attach to the lung and stomach meridians, small intestinl channel.It is cooling blood and hemostasis, clearing heat and detoxicating, cure mainly oedema, jaundice, urine not
The diseases such as profit, pyreticosis polydipsia, stomach energy is vomitted the sound of vomiting.
The yellow rose of Sharon：Bitter, acrid, cold, return lung warp.Clearing and antitussive, removing toxicity for detumescence can control affection of exogenous wind-heat, cough, convulsive seizure due to phlegm-fire pent-up, cough up
Phlegm Huang is thick, cough with lung heat, ulcerative carbuncle pyogenic infections, bronchitis.
Caulis bambusae in taenian：It is sweet, cold nature.Return lung, stomach, the heart, gallbladder channel.For phlegm-heat cough, courage fire hold under the arm phlegm, palpitate with fear it is not peaceful, vexed
The diseases such as insomnia, middle wind phlegm fan, aphasia with stiff tongue, gastropyretic vomiting.
Herba Kalimeridis：Cool in nature, taste is pungent, Return liver, stomach, lung channel.There is cooling blood and hemostasis, clearing heat and promoting diuresis, removing toxicity for detumescence, it is main
Control the diseases such as jaundice, rush down dysentery, stranguria with turbid discharge.
The Radix Astragali：It is sweet, tepor, return lung, spleen, liver and kidney channel.The Radix Astragali have enhancing body's immunity, liver protection, diuresis, anti-aging,
Resisting stress, step-down and wide antibacterial action.Radix Astragali energy coronary artery dilator, improves myocardial blood supply, improves immunologic function.
Pseudo-ginseng：Temperature, sweet, slight bitter, Return liver, stomach, large intestine channel.With hemostasis, promoting blood circulation and removing blood stasis, detumescence ding-tong, strengthening by means of tonics, resist
The effects such as fatigue, raising body's immunity.
Dateplum persimmon：Dateplum persimmon is warm in nature sweet, rich in protein, carbohydrate, organic acid, vitamin B and vitamin E, and phosphorus, calcium, iron
Deng trace element, also various nutrients, the effects such as have tonifying kidney and nourishing stomach, improving eyesight promoting blood circulation, promoting diuresis to remove toxic substance.
The bark of eucommia：Sweet, temperature, returns liver and kidney channel.With filling liver kidney, the effects such as control spinal column ache, foot and knee flaccidity, to immune system,
Internal system, central nervous system, the circulatory system and urinary system have different degrees of adjustment effect, and the bark of eucommia excited can be hung down
Body-interrenal system, strengthens adrenal cortex function.
Beneficial effects of the present invention are：
1. Chinese medicine preparation of the present invention has the effects such as clearing heat and detoxicating, strengthening the spleen and stomach, strongly fragrant active solution, diuresis, can accelerate toxin
Excretion, for pesticide poisoning sequela such as indigestion, do not feel like eating, have no peace of mind, mental depression etc. has special efficacy, this hair
Bright Chinese medicine preparation is convenient to take and has no toxic side effect, evident in efficacy to treatment pesticide poisoning sequela.
2. the present invention carries out traditional Chinese medicine extraction using ultrasonic extraction, and the effective ingredient in crude drug cell can be made molten rapidly
Go out, and do not destroy the chemical constitution of effective ingredient, the time is short, and recovery rate is high.
3. volatile oil is extracted when the present invention prepares Chinese medicine preparation, can effective guarantee Chinese medicine preparation curative effect, to waving
Hair oil carries out inclusion and is made particle using beta-schardinger dextrin, and it is a kind of physical process, and chemical change does not occur, and it can increase volatilization
The solubility and dissolution rate of oil, can improve the stability of volatile oil, make volatile oil powdered, reduce its volatility, improve
The utilization rate of volatile oil.
4. the present invention can be promoted water-oil separating, be subtracted using saturated sodium-chloride water solution in the extraction of volatile oil as solvent
Few solubility of the volatile oil in water.
Specific embodiment
Technical solution of the invention is further illustrated with reference to specific embodiment, embodiment is not to be construed as right
The limitation of technical solution.
Embodiment 1：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：18 parts of Radix Glycyrrhizae, chrysanthemum
Spend 22 parts, 12 parts of dried orange peel, 10 parts of Ligusticum wallichii, 12 parts of Ramulus Taxilli, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome, 14 parts of Radix Angelicae Sinensis, 8 parts of Semen Lablab Album, soil Fu
25 parts of Siberian cocklebur, 6 parts of lalang grass rhizome, yellow 8 parts of the rose of Sharon, 15 parts of caulis bambusae in taenian, 6 parts of Herba Kalimeridis, 7 parts of the Radix Astragali, 12 parts of pseudo-ginseng, 7 parts of dateplum persimmon, 12 parts of the bark of eucommia.
The preparation method of the Chinese medicine preparation of pesticide poisoning sequela is treated, is comprised the following steps：
(1) dry, crush and weigh：Crushed after each bulk drug is dried into 3h at 65 DEG C respectively, crossed 60 mesh sieves, pressed
Ratio weighs the crushed material of each bulk drug；
(2) extraction and treatment of volatile oil：Add its gross mass after the crushed material of chrysanthemum, dried orange peel, the bighead atractylodes rhizome and Radix Angelicae Sinensis is mixed
After 10 times of amount saturated sodium-chloride water solution immersion 2h, using extraction by steam distillation volatile oil, just distillate is collected, to first distillate
Secondary steam distillation is carried out, rectifying liquid is obtained, is extracted with ether, anhydrous sodium sulfate drying 8h, be concentrated under reduced pressure, obtain volatile oil, medicine
Slag and fried liquid retain standby, then by volatile oil beta-cyclodextrin inclusion compound, are made inclusion particle；
(3) extract：By Radix Glycyrrhizae, Ligusticum wallichii, Ramulus Taxilli, Chinese yam, Semen Lablab Album, smilax, lalang grass rhizome, the yellow rose of Sharon, caulis bambusae in taenian, Herba Kalimeridis,
Add the water immersion 30min of 10 times of amounts of its gross mass after the Radix Astragali, pseudo-ginseng, dateplum persimmon, the crushed material mixing of the bark of eucommia, add step (2)
In the dregs of a decoction and fried liquid, extracted 3 times with ultrasonic extractor, each 40min is filtered afterwards, aqueous extract through it is concentrated under reduced pressure,
Freeze-drying obtains water extract；
(4) preparation：Step (2) gained inclusion particle and step (3) gained water extract are well mixed, auxiliary material is added,
Granulation is tabletted, is coated, and obtains final product.
Embodiment 2：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：20 parts of Radix Glycyrrhizae, chrysanthemum
Spend 20 parts, 15 parts of dried orange peel, 8 parts of Ligusticum wallichii, 15 parts of Ramulus Taxilli, 6 parts of Chinese yam, 12 parts of the bighead atractylodes rhizome, 12 parts of Radix Angelicae Sinensis, 10 parts of Semen Lablab Album, soil Fu
20 parts of Siberian cocklebur, 8 parts of lalang grass rhizome, yellow 5 parts of the rose of Sharon, 18 parts of caulis bambusae in taenian, 4 parts of Herba Kalimeridis, 10 parts of the Radix Astragali, 8 parts of pseudo-ginseng, 10 parts of dateplum persimmon, 8 parts of the bark of eucommia.
The preparation method of the Chinese medicine preparation of pesticide poisoning sequela is treated, is comprised the following steps：
(1) dry, crush and weigh：Crushed after each bulk drug is dried into 5h at 55 DEG C respectively, crossed 80 mesh sieves, pressed
Ratio weighs the crushed material of each bulk drug；
(2) extraction and treatment of volatile oil：Add its gross mass 8 after the crushed material of chrysanthemum, dried orange peel, the bighead atractylodes rhizome and Radix Angelicae Sinensis is mixed
Again after amount saturated sodium-chloride water solution immersion 1h, using extraction by steam distillation volatile oil, just distillate is collected, first distillate is entered
The secondary steam distillation of row, obtains rectifying liquid, is extracted with ether, anhydrous sodium sulfate drying 6h, is concentrated under reduced pressure, and obtains volatile oil, the dregs of a decoction
Retain standby with fried liquid, then by volatile oil beta-cyclodextrin inclusion compound, be made inclusion particle；
(3) extract：By Radix Glycyrrhizae, Ligusticum wallichii, Ramulus Taxilli, Chinese yam, Semen Lablab Album, smilax, lalang grass rhizome, the yellow rose of Sharon, caulis bambusae in taenian, Herba Kalimeridis,
Add the water immersion 40min of 11 times of amounts of its gross mass after the Radix Astragali, pseudo-ginseng, dateplum persimmon, the crushed material mixing of the bark of eucommia, add step (2)
In the dregs of a decoction and fried liquid, extracted 2 times with ultrasonic extractor, each 45min is filtered afterwards, aqueous extract through it is concentrated under reduced pressure,
It is spray-dried to obtain water extract；
(4) preparation：Step (2) gained inclusion particle and step (3) gained water extract are well mixed, auxiliary material is added,
Granulation is tabletted, is coated, and obtains final product.
Embodiment 3：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：15 parts of Radix Glycyrrhizae, chrysanthemum
Spend 25 parts, 8 parts of dried orange peel, 12 parts of Ligusticum wallichii, 10 parts of Ramulus Taxilli, 12 parts of Chinese yam, 8 parts of the bighead atractylodes rhizome, 16 parts of Radix Angelicae Sinensis, 6 parts of Semen Lablab Album, smilax
30 parts, 4 parts of lalang grass rhizome, yellow 10 parts of the rose of Sharon, 12 parts of caulis bambusae in taenian, 8 parts of Herba Kalimeridis, 5 parts of the Radix Astragali, 15 parts of pseudo-ginseng, 6 parts of dateplum persimmon, 15 parts of the bark of eucommia.
The preparation method of the Chinese medicine preparation of pesticide poisoning sequela is treated, is comprised the following steps：
(1) dry, crush and weigh：Crushed after each bulk drug is dried into 4h at 60 DEG C respectively, crossed 40 mesh sieves, pressed
Ratio weighs the crushed material of each bulk drug；
(2) extraction and treatment of volatile oil：Add its gross mass after the crushed material of chrysanthemum, dried orange peel, the bighead atractylodes rhizome and Radix Angelicae Sinensis is mixed
After 12 times of amount saturated sodium-chloride water solution immersion 1.5h, using extraction by steam distillation volatile oil, just distillate is collected, to fore-running
Liquid carries out secondary steam distillation, obtains rectifying liquid, is extracted with ether, anhydrous sodium sulfate drying 7h, is concentrated under reduced pressure, and obtains volatile oil,
The dregs of a decoction and fried liquid retain standby, then by volatile oil beta-cyclodextrin inclusion compound, are made inclusion particle；
(3) extract：By Radix Glycyrrhizae, Ligusticum wallichii, Ramulus Taxilli, Chinese yam, Semen Lablab Album, smilax, lalang grass rhizome, the yellow rose of Sharon, caulis bambusae in taenian, Herba Kalimeridis,
After the Radix Astragali, pseudo-ginseng, dateplum persimmon, the crushed material mixing of the bark of eucommia plus 9 times of its gross mass amount water immersion 20min, in adding step (2)
The dregs of a decoction and fried liquid, extracted 2 times with ultrasonic extractor, each 30min is filtered afterwards, and aqueous extract is through concentrated under reduced pressure, cold
Lyophilized dry water extract；
(4) preparation：Step (2) gained inclusion particle and step (3) gained water extract are well mixed, auxiliary material is added,
Granulation is tabletted, is coated, and obtains final product.
Embodiment 4：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：18 parts of Radix Glycyrrhizae, chrysanthemum
Spend 20 parts, 8 parts of dried orange peel, 12 parts of Ligusticum wallichii, 12 parts of Ramulus Taxilli, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome, 16 parts of Radix Angelicae Sinensis, 9 parts of Semen Lablab Album, soil Fu
28 parts of Siberian cocklebur, 8 parts of lalang grass rhizome, yellow 5 parts of the rose of Sharon, 15 parts of caulis bambusae in taenian, 6 parts of Herba Kalimeridis, 7 parts of the Radix Astragali, 15 parts of pseudo-ginseng, 6 parts of dateplum persimmon, 8 parts of the bark of eucommia.
The preparation method of the Chinese medicine preparation of pesticide poisoning sequela is treated, is comprised the following steps：
(1) dry, crush and weigh：Crushed after each bulk drug is dried into 5h at 60 DEG C respectively, crossed 60 mesh sieves, pressed
Ratio weighs the crushed material of each bulk drug；
(2) extraction and treatment of volatile oil：Add its gross mass 9 after the crushed material of chrysanthemum, dried orange peel, the bighead atractylodes rhizome and Radix Angelicae Sinensis is mixed
Again after amount saturated sodium-chloride water solution immersion 2h, using extraction by steam distillation volatile oil, just distillate is collected, first distillate is entered
The secondary steam distillation of row, obtains rectifying liquid, is extracted with ether, anhydrous sodium sulfate drying 7h, is concentrated under reduced pressure, and obtains volatile oil, the dregs of a decoction
Retain standby with fried liquid, then by volatile oil beta-cyclodextrin inclusion compound, be made inclusion particle；
(3) extract：By Radix Glycyrrhizae, Ligusticum wallichii, Ramulus Taxilli, Chinese yam, Semen Lablab Album, smilax, lalang grass rhizome, the yellow rose of Sharon, caulis bambusae in taenian, Herba Kalimeridis,
Add the water immersion 30min of 10 times of amounts of its gross mass after the Radix Astragali, pseudo-ginseng, dateplum persimmon, the crushed material mixing of the bark of eucommia, add step (2)
In the dregs of a decoction and fried liquid, extracted 3 times with ultrasonic extractor, each 45min is filtered afterwards, aqueous extract through it is concentrated under reduced pressure,
It is spray-dried to obtain water extract；
(4) preparation：Step (2) gained inclusion particle and step (3) gained water extract are well mixed, auxiliary material is added,
Granulation is tabletted, is coated, and obtains final product.
Embodiment 5：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：15 parts of Radix Glycyrrhizae, chrysanthemum
Spend 22 parts, 13 parts of dried orange peel, 8 parts of Ligusticum wallichii, 15 parts of Ramulus Taxilli, 8 parts of Chinese yam, 8 parts of the bighead atractylodes rhizome, 12 parts of Radix Angelicae Sinensis, 7 parts of Semen Lablab Album, smilax
23 parts, 5 parts of lalang grass rhizome, yellow 8 parts of the rose of Sharon, 12 parts of caulis bambusae in taenian, 8 parts of Herba Kalimeridis, 5 parts of the Radix Astragali, 8 parts of pseudo-ginseng, 8 parts of dateplum persimmon, 12 parts of the bark of eucommia.
The preparation method of Chinese medicine preparation of pesticide poisoning sequela is treated with embodiment 1.
Embodiment 6：
A kind of Chinese medicine preparation for treating pesticide poisoning sequela, is made up of the bulk drug of following weight portion：20 parts of Radix Glycyrrhizae, chrysanthemum
Spend 25 parts, 8 parts of dried orange peel, 8 parts of Ligusticum wallichii, 15 parts of Ramulus Taxilli, 12 parts of Chinese yam, 8 parts of the bighead atractylodes rhizome, 12 parts of Radix Angelicae Sinensis, 10 parts of Semen Lablab Album, smilax
30 parts, 4 parts of lalang grass rhizome, yellow 5 parts of the rose of Sharon, 18 parts of caulis bambusae in taenian, 8 parts of Herba Kalimeridis, 5 parts of the Radix Astragali, 8 parts of pseudo-ginseng, 10 parts of dateplum persimmon, 15 parts of the bark of eucommia.
The preparation method of Chinese medicine preparation of pesticide poisoning sequela is treated with embodiment 2.
Clinical efficacy is summarized：
1st, general data：This Chinese medicine preparation is used to treat pesticide poisoning sequela patient 100, wherein man 46, female
54, age 16-63 Sui, the course of disease-three years 15 days.
2nd, usage and dosage：It is early, middle and late daily respectively to take Chinese medicine preparation 3g, two obtained by the present embodiment 1 during clinical practice
The Zhou Weiyi courses for the treatment of, avoided eating anything raw or cold during continuously taking the 2-3 course for the treatment of, medication according to the state of an illness, it is pungent, stimulate and greasy thing.
3rd, diagnostic criteria：
(1) have wrongly take, from clothes and exposed to pesticides medical history.
(2) there is the classical symptom of pesticide poisoning：Weak, tinnitus is forgetful, insomnia and dreamful sleep, dry throat, dysphoria in chestpalms-soles, spirit
Dispirited, loss of appetite, n and V, diarrhoea etc..
4th, criterion of therapeutical effect：
Criterion of therapeutical effect：《Selected with prescription according to disease of tcm diagnosis and treatment standard》Formulate.
(1) cure：Symptom disappears, mood is normal, diet is normal, life can take care of oneself；
(2) it is effective：Symptom disappears, mood is normal, and life can take care of oneself substantially；
(3) effectively：Symptom mitigation, mood is basicly stable, and life can take care of oneself substantially, often need medicine to maintain；
(4) it is invalid：Through treating without any change.
5th, therapeutic effect：In the clinical observation case, the 2-3 course for the treatment of of taking medicine, healing 35, effective 47, effective 11,
Invalid 7, total effective rate is 93%, and toxic and side effect does not occur during treatment.It can thus be appreciated that the obtained Chinese medicine preparation energy of the present invention
It is enough safely and effectively to treat pesticide poisoning sequela.
6th, model case
Case 1：Zeng, female 24 years old, takes organophosphorus pesticide certainly, in emergency department through rescuing, is transferred to after stable disease interior
Section's ward continual cure, leaves hospital after one week, occurs weak, insomnia and dreamful sleep afterwards, has difficulty in breathing and have no peace of mind, after be hospitalized for treatment nothing
Any change, after taking two courses for the treatment of of Chinese medicine preparation described in the embodiment of the present invention 1, weak, insomnia and dreamful sleep, expiratory dyspnea, the heart
God's symptom such as not peaceful substantially mitigates, and continues to be fully recovered after taking a course for the treatment of, and livelihood restoration is normal, and follow-up is not recurred after 1 year.
Case 2：
Liu, man, 40 years old, due to long-time exposed to pesticides, occurs in that forgetful tinnitus, lassitude, loss of appetite, evil
The clinical symptoms such as the heart, vomiting, fail to respond to any medical treatment through many places, after taking two courses for the treatment of of Chinese medicine preparation described in the embodiment of the present invention 1, disease
Shape substantially mitigates, and continues to be fully recovered after taking a course for the treatment of.
Claims (6)
1. a kind of Chinese medicine preparation for treating pesticide poisoning sequela, it is characterised in that be made up of the bulk drug of following weight portion：It is sweet
Careless 15-20 parts, chrysanthemum 20-25 parts, dried orange peel 8-15 parts, Ligusticum wallichii 8-12 parts, Ramulus Taxilli 10-15 parts, Chinese yam 6-12 parts, bighead atractylodes rhizome 8-12
Part, Radix Angelicae Sinensis 12-16 part, Semen Lablab Album 6-10 parts, smilax 20-30 parts, lalang grass rhizome 4-8 parts, Huang 5-10 parts of the rose of Sharon, caulis bambusae in taenian 12-18 parts, horse
Blue head 4-8 parts, Radix Astragali 5-10 parts, pseudo-ginseng 8-15 parts, dateplum persimmon 6-10 parts, bark of eucommia 8-15 parts.
2. the Chinese medicine preparation of pesticide poisoning sequela is treated according to claim 1, it is characterised in that by following weight portion
Bulk drug is made：18 parts of Radix Glycyrrhizae, 22 parts of chrysanthemum, 12 parts of dried orange peel, 10 parts of Ligusticum wallichii, 12 parts of Ramulus Taxilli, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome,
14 parts of Radix Angelicae Sinensis, 8 parts of Semen Lablab Album, 25 parts of smilax, 6 parts of lalang grass rhizome, yellow 8 parts of the rose of Sharon, 15 parts of caulis bambusae in taenian, 6 parts of Herba Kalimeridis, 7 parts of the Radix Astragali, pseudo-ginseng
12 parts, 7 parts of dateplum persimmon, 12 parts of the bark of eucommia.
3. the preparation method of the Chinese medicine preparation of the treatment pesticide poisoning sequela according to claim any one of 1-2, it is special
Levy and be, comprise the following steps：
(1) dry, crush and weigh：Crushed after each bulk drug is dried into 3-5h at 55-65 DEG C respectively, crossed 40-80 mesh
Sieve, weighs the crushed material of each bulk drug in proportion；
(2) extraction and treatment of volatile oil：Add its gross mass 8-12 after the crushed material of chrysanthemum, dried orange peel, the bighead atractylodes rhizome and Radix Angelicae Sinensis is mixed
Again after amount saturated sodium-chloride water solution immersion 1-2h, using extraction by steam distillation volatile oil, just distillate is collected, to first distillate
Secondary steam distillation is carried out, rectifying liquid is obtained, is extracted with ether, anhydrous sodium sulfate drying, be concentrated under reduced pressure, obtain volatile oil, the dregs of a decoction
Retain standby with fried liquid, then by volatile oil beta-cyclodextrin inclusion compound, be made inclusion particle；
(3) extract：By Radix Glycyrrhizae, Ligusticum wallichii, Ramulus Taxilli, Chinese yam, Semen Lablab Album, smilax, lalang grass rhizome, the yellow rose of Sharon, caulis bambusae in taenian, Herba Kalimeridis, the Radix Astragali,
The water immersion 20-40min for adding 9-11 times of its gross mass to measure after pseudo-ginseng, dateplum persimmon, the crushed material mixing of the bark of eucommia, adds step (2)
In the dregs of a decoction and fried liquid, with ultrasonic extractor extract 2-3 time, each 30-45min is filtered afterwards, aqueous extract through depressurize
Concentration, dry water extract；
(4) preparation：Step (2) gained inclusion particle and step (3) gained water extract are well mixed, auxiliary material, granulation is added
It is tabletted, it is coated, obtain final product.
4. it is according to claim 3 treatment pesticide poisoning sequela Chinese medicine preparation preparation method, it is characterised in that institute
The mesh number for stating sieving in step (1) is 60 mesh.
5. it is according to claim 3 treatment pesticide poisoning sequela Chinese medicine preparation preparation method, it is characterised in that institute
State and use anhydrous sodium sulfate drying 6-8h in step (2).
6. it is according to claim 3 treatment pesticide poisoning sequela Chinese medicine preparation preparation method, it is characterised in that institute
It is freeze-drying or spray drying to state the drying mode in step (3).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114470113A (en) * | 2022-01-22 | 2022-05-13 | 扬州大学附属医院 | Traditional Chinese medicine composition for relieving glyphosate herbicide poisoning and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547170A (en) * | 2014-12-25 | 2015-04-29 | 王从政 | Traditional Chinese medicine preparation for treating sequelae of pesticide intoxication |
| CN104922433A (en) * | 2015-05-25 | 2015-09-23 | 肖方华 | Traditional Chinese medicine composition for removing pesticide toxicity and quitting drug addiction |
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2016
- 2016-11-14 CN CN201611000055.8A patent/CN106729198A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547170A (en) * | 2014-12-25 | 2015-04-29 | 王从政 | Traditional Chinese medicine preparation for treating sequelae of pesticide intoxication |
| CN104922433A (en) * | 2015-05-25 | 2015-09-23 | 肖方华 | Traditional Chinese medicine composition for removing pesticide toxicity and quitting drug addiction |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114470113A (en) * | 2022-01-22 | 2022-05-13 | 扬州大学附属医院 | Traditional Chinese medicine composition for relieving glyphosate herbicide poisoning and preparation method thereof |
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