CN1315514C - Heat-clearing and detoxicating effervescence tablet and its preparing process - Google Patents
Heat-clearing and detoxicating effervescence tablet and its preparing process Download PDFInfo
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- CN1315514C CN1315514C CNB2005100987226A CN200510098722A CN1315514C CN 1315514 C CN1315514 C CN 1315514C CN B2005100987226 A CNB2005100987226 A CN B2005100987226A CN 200510098722 A CN200510098722 A CN 200510098722A CN 1315514 C CN1315514 C CN 1315514C
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Abstract
The present invention relates to a heat-clearing and detoxication effervescence tablet and a preparation method thereof, which belongs to the field of traditional Chinese medicine. The effervescence tablet is composed of heat-clearing and detoxication powdered extract, tartrate, sodium bicarbonate, a sweetening agent, a filling agent and a lubricant agent. The present invention has the advantages of rational matching of the kinds and the dosage of auxiliary materials and basic remedies, simple preparation process, stable quality of the effervescence tablet and good effervescence effect; the present invention is a heat-clearing and detoxication effervescence tablet and a preparation method thereof and the heat-clearing and detoxication effervescence tablet has the characteristics of high bioavailability, rapid effect taking, convenient taking, stable quality, good mouth feelings and convenient transportation and carrying.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, more specifically relate to a kind of heat-clearing and detoxicating effervescence tablet and preparation method thereof.
Background technology
Heat-clearing and detoxicating effervescence tablet is former dosage form QINGRE JIEDU KOUFUYE (one one of Chinese Pharmacopoeia records, and sees Appendix 1) to be changed through agent form, and former QINGRE JIEDU KOUFUYE is used for the flushed complexion of generating heat due to the hyperactivity of toxic heat, and is irritated thirsty, diseases such as laryngopharynx swelling and pain; Influenza, upper respiratory tract infection are seen above-mentioned patient.Its curative effect is fine, is subjected to very much the welcome of extensive patients, and the market sales volume is bigger.But oral liquid is in that the aspect such as to transport, carry all inconvenient, and mouthfeel is also bad; And liquid preparation less stable often, also might microbiological contamination produce sour aerogenesis and problem such as set off an explosion has limited the use to it.
The oral administration effervescing sheet is to be the novel quick-release tablet of disintegrating agent with the effervescent, effervescent is dissolved in hot water but both have, but effervescent is dissolved in the advantage of directly taking behind the cold water again, and onset is rapid, bioavailability is high, and mouthfeel is good, is suitable for child especially, the old man takes.With SHUANGHUANGLIAN KOUFUYE make into effervescent tablet both can keep former dosage form be easy to oral, absorb characteristics rapidly, simultaneously again because it is a solid preparation, transportation, easy to carry, steady quality, overcome the shortcoming that former preparation is preserved, carried inconvenience, meet the modern requirement of Chinese medicine preparation, have vast market prospect.
Chinese medicine effervescent tablet Chinese medicine extractum proportion is very big, difficult point is the selection of drug extract powder and pharmaceutic adjuvant kind and ratio, proper supplementary material and appropriate ratio have been selected, can reduce supplementary product consumption, preparation technology is simple, easy-formation, be difficult for moisture absorption, effervescent speed is fast, and effervescent is effective, is homogeneous solution behind the effervescent.
Summary of the invention
For solving not easy-formation of Chinese medicine effervescent tablet, disintegrate is slow, and clarity is bad, and problems such as poor stability the invention provides a kind of principal agent, supplementary product kind reasonable mixture ratio, forming, heat-clearing and detoxicating effervescence tablet of good stability and preparation method thereof.
The present invention is implemented by the following technical programs.
A kind of heat-clearing and detoxicating effervescence tablet of the present invention, it is made up of following components by part by weight:
Heat-clearing and toxic substances removing extract powder, tartaric acid, sodium bicarbonate are 92-99 part altogether, heat-clearing and toxic substances removing extract powder: tartaric acid: sodium bicarbonate is 1: 1: 1, filler 0-5 part, lubricant 0.5-1 part, sweeting agent 0.5-2 part.
Wherein said heat-clearing and toxic substances removing extract powder is made by weight by following raw material:
Gypsum Fibrosum 10 Flos Loniceraes 2 Radix Scrophulariaes 1.6 Radix Rehmanniae 1.2 Fructus Forsythiaes 1 Fructus Gardeniae 1
0.8 Radix Ophiopogonis 0.8 of Herba Gueldenstaedtiae 1 Radix Scutellariae 1 Radix Gentianae 1 Radix Isatidis 1 Rhizoma Anemarrhenae
Sweeting agent is selected from a kind of of stevioside, betanin, Aspartane, is preferably Aspartane; Filler is selected from a kind of in lactose, mannitol, the xylitol, is preferably mannitol, xylitol; Lubricant is selected from a kind of in polyethylene glycol 6000, Macrogol 4000, the magnesium stearate.
Its preparation method can be mainly to comprise following process steps:
(1) ten two flavor medical material, except that Flos Lonicerae, Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 8-12 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, add ethanol, make to contain the alcohol amount and reach 65%～70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, and drying under reduced pressure is ground into fine powder.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; Heat-clearing and toxic substances removing extractum fine powder and tartaric acid, sodium bicarbonate, sweeting agent, filler are carried out proportion optimization by the umber of above-mentioned each component of effervescent tablet, to determine optimum formula.Filler is used for regulating total amount, and sweeting agent is used for improving mouthfeel, and lubricant plays fluidizer and lubrication when tabletting.
Below be heat-clearing and detoxicating effervescence tablet prescription screening experiment:
One, the selection of sour agent and alkaline agent
In the selection of effervescent, sodium bicarbonate is as carbon source, and consumption is few, and gas production is big, and the present invention adopts sodium bicarbonate as carbon source.Because the easy moisture absorption of Chinese medical concrete powder, viscosity is big, so the selection of acid source is very important.Take by weighing a certain amount of medicated powder and mix evenly, granulate, carry out different preparations shaping prescriptions and screen, the results are shown in Table 1 with dehydrated alcohol with acid, alkali.
The screening of the different preparations shaping soda acid of table 1 prescription
| The prescription number | Medicated powder (g) | Acid kind (g) | Alkali kind (g) | The result |
| 1 2 3 4 5 6 | 14 14 14 14 14 14 | Tartaric acid 14 adipic acids 14 succinic acid 14 malic acids 14 fumaric acid 14 citric acids 14 | Sodium bicarbonate 14 sodium bicarbonate 14 sodium bicarbonate 14 sodium bicarbonate 14 sodium bicarbonate 14 sodium bicarbonate 14 | The all good effervescent of granulation, tabletting, effervescent is too slow, the bad moisture absorption of effect, the moisture absorption of can't granulating, can't granulate better, effervescent lumps slowly, can't granulate |
The result shows: the effect of prescription 1 is better, and promptly the preferred tartaric acid of effervescent is as acid source, and sodium bicarbonate is as carbon source.
Two, medicated powder, the screening of effervescent proportioning
To effervescent tablet quality influence maximum in the Chinese medicine effervescent tablet is soda acid ratio in effervescent and drug ratios and the effervescent, be screening formula, based on above-mentioned prescription 1, be factor in soda acid ratio in the ratio of shared weight of effervescent and the effervescent, do 4 horizontal comprehensive tests.
Test method: get the not commensurability medicated powder and the soda acid of different proportionings (the prescription total amount is 45g) respectively, evenly mixed, granulate with dehydrated alcohol, drying, tabletting the results are shown in Table 2.
Table 2 medicated powder, effervescent proportioning screening table
| Sequence number | Medicated powder accounts for sheet anharmonic ratio example | Effervescent accounts for sheet anharmonic ratio example | Acid accounts for the effervescent ratio | The effervescent effect | Disintegration time (branch) |
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 | 1/3 1/3 1/3 1/3 2/5 2/5 2/5 2/5 1/2 1/2 1/2 1/2 3/5 3/5 3/5 3/5 | 2/3 2/3 2/3 2/3 3/5 3/5 3/5 3/5 1/2 1/2 1/2 1/2 2/5 2/5 2/5 2/5 | 40％ 45％ 50％ 55％ 40％ 45％ 50％ 55％ 40％ 45％ 50％ 55％ 40％ 45％ 50％ 55％ | +++ ++++ ++++ +++ +++ +++ +++ +++ ++ ++ ++ ++ + + + + | Exceeded in 1 minute 1.1 1.2 2.1 4.4 4.4 4.6 4.7 to exceed in limited time to exceed in limited time to exceed in limited time to exceed in limited time to exceed in limited time to exceed in limited time and exceed in limited time in limited time |
Comprehensive relatively, effervescent effect 2,3,4,5,6,7,8 all can, 1 gas release is too big, 5,6,7,8 a little less than, 2,3 prescription gas releases are moderate, disintegrate is very fast, is that the soda acid proportioning is further groped on the basis with 2,3 prescriptions.
Three, effervescent consumption screening
Know according to above-mentioned result of the test, effervescent tablet of the present invention is promptly plastic without filler, consider that different batches Chinese crude drug paste-forming rate is variant in the production, need there be 0-5% filler space to regulate total amount, simultaneously for improving mouthfeel, the sweeting agent that can add 0.5-2%, particulate flowability when increasing tabletting can add the lubricant of 0.5-1%.
Test method: every group of test all feeds intake by 100, take by weighing prescription dried cream powder 145g, add not commensurability tartaric acid, sodium bicarbonate and an amount of filler, sweeting agent mixing, with dehydrated alcohol granulation, drying, add lubricant, mixing, tabletting, every heavy 4.5g/ sheet the results are shown in following table, the consumption during the consumption of table Chinese medicine powder, acid, alkali is every.
Table 3 effervescent consumption screening table
| Sequence number | Medicated powder (g) | Acid (g) | Alkali (g) | Disintegration time | Medicinal liquid evaluation behind the effervescent |
| 12 | 1.45 1.45 | 1.31 1.38 | 1.59 1.52 | 1 minute 40 seconds 1 minute 42 seconds | Medicinal liquid has a small amount of floccule, and mouthfeel is general.Medicinal liquid has a small amount of floccule, and mouthfeel is general. |
| 3 | 1.45 | 1.45 | 1.45 | 1 minute 50 seconds | The medicinal liquid clarification, mouthfeel is good. |
| 4 | 1.45 | 1.51 | 1.39 | 1 minute 12 seconds | Medicinal liquid is muddy slightly, and mouthfeel is general. |
Table 3 result of the test shows, effervescent tablet of the present invention with medicated powder, tartaric acid, sodium bicarbonate be 1: 1: 1 be best proportion.
Four, moulding process study on the stability
In order to investigate the stability of moulding process, we place 40 ℃, relative humidity with the effervescent tablet of two aluminum laminated films packings is 75% climatic chamber, places 1 month, takes out, and measures appearance character, the variation of effervescent time before and after its test, the results are shown in Table 7.
Comparing result before and after table 4 accelerated test
| Sample | Appearance character | The effervescent time |
| After testing before the test | Sepia tablet sepia tablet | 1 minute 55 seconds 1 minute 48 seconds |
The result shows: this medicine has no significant change at aspects such as appearance color, physical behavior, effervescent times before and after the accelerated test, illustrates that this medicine is basicly stable, and moulding process is reasonable.
It is reasonable that heat-clearing and detoxicating effervescence tablet principal agent of the present invention, adjuvant are formed with the proportioning selection, and effervescent is effective, is homogeneous solution behind the effervescent.The heat-clearing and detoxicating effervescence tablet preparation technology who makes by the present invention is simple, steady quality.
The specific embodiment
The present invention is described further by embodiment.
Embodiment 1
According to the shared umber of each raw material in the heat-clearing and detoxicating effervescence tablet, it is standby to get following recipe quantity raw material (by the gram number):
Gypsum Fibrosum 6700g Flos Lonicerae 1340g Radix Scrophulariae 1070g Radix Rehmanniae 800g Fructus Forsythiae 670g Fructus Gardeniae 670g
Herba Gueldenstaedtiae 670g Radix Scutellariae 670g Radix Gentianae 670g Radix Isatidis 670g Rhizoma Anemarrhenae 540g 540g Radix Ophiopogonis
The heat-clearing and detoxicating effervescence tablet preparation method comprises following process steps:
(1) ten two flavor medical material removes Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%～700%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, get heat-clearing and toxic substances removing extract powder 1380g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity heat-clearing and toxic substances removing extractum fine powder 1380g and tartaric acid 1380g, sodium bicarbonate 1380g, A Sibapatan 90g, lactose 225g mixing, with dehydrated alcohol granulate, drying, add PEG4000 45g mixing, be pressed into 1000, promptly.
Embodiment 2
According to the shared umber of each raw material in the heat-clearing and detoxicating effervescence tablet, it is standby to get following recipe quantity raw material (by the gram number):
Gypsum Fibrosum 6700g Flos Lonicerae 1340g Radix Scrophulariae 1070g Radix Rehmanniae 800g Fructus Forsythiae 670g Fructus Gardeniae 670g
Herba Gueldenstaedtiae 670g Radix Scutellariae 670g Radix Gentianae 670g Radix Isatidis 670g Rhizoma Anemarrhenae 540g 540g Radix Ophiopogonis
The heat-clearing and detoxicating effervescence tablet preparation method comprises following process steps:
(1) ten two flavor medical material removes Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%～70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, get heat-clearing and toxic substances removing extract powder 1485g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity heat-clearing and toxic substances removing extractum fine powder 1485g and tartaric acid 1485g, sodium bicarbonate 1485g, betanin 22.5g mixing, with dehydrated alcohol granulate, drying, add PEG6000 22.5g mixing, be pressed into 1000, promptly.
Embodiment 3
According to the shared umber of each raw material in the heat-clearing and detoxicating effervescence tablet, it is standby to get following recipe quantity raw material (by the gram number):
Gypsum Fibrosum 6700g Flos Lonicerae 1340g Radix Scrophulariae 1070g Radix Rehmanniae 800g Fructus Forsythiae 670g Fructus Gardeniae 670g
Herba Gueldenstaedtiae 670g Radix Scutellariae 670g Radix Gentianae 670g Radix Isatidis 670g Rhizoma Anemarrhenae 540g 540g Radix Ophiopogonis
The heat-clearing and detoxicating effervescence tablet preparation method comprises following process steps:
(1) ten two flavor medical material removes Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%～70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, get heat-clearing and toxic substances removing extract powder 1433g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity heat-clearing and toxic substances removing extractum fine powder 1433g and tartaric acid 1433g, sodium bicarbonate 1433g, stevioside 45g, xylitol 112.5g mixing, with dehydrated alcohol granulate, drying, add magnesium stearate 43.5g mixing, be pressed into 1000, promptly.
Embodiment 4
According to the shared umber of each raw material in the heat-clearing and detoxicating effervescence tablet, it is standby to get following recipe quantity raw material (by the gram number):
Gypsum Fibrosum 6700g Flos Lonicerae 1340g Radix Scrophulariae 1070g Radix Rehmanniae 800g Fructus Forsythiae 670g Fructus Gardeniae 670g
Herba Gueldenstaedtiae 670g Radix Scutellariae 670g Radix Gentianae 670g Radix Isatidis 670g Rhizoma Anemarrhenae 540g 540g Radix Ophiopogonis
The heat-clearing and detoxicating effervescence tablet preparation method comprises following process steps:
(1) ten two flavor medical material removes Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%～70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, get heat-clearing and toxic substances removing extract powder 1410g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity heat-clearing and toxic substances removing extractum fine powder 1410g and tartaric acid 1410g, sodium bicarbonate 1410g, A Sibapatan 34g, mannitol 198g mixing, with dehydrated alcohol granulate, drying, add PEG4000 38g mixing, be pressed into 1000, promptly.
Embodiment 5
According to the shared umber of each raw material in the heat-clearing and detoxicating effervescence tablet, it is standby to get following recipe quantity raw material (by the gram number):
Gypsum Fibrosum 6700g Flos Lonicerae 1340g Radix Scrophulariae 1070g Radix Rehmanniae 800g Fructus Forsythiae 670g Fructus Gardeniae 670g
Herba Gueldenstaedtiae 670g Radix Scutellariae 670g Radix Gentianae 670g Radix Isatidis 670g Rhizoma Anemarrhenae 540g 540g Radix Ophiopogonis
The heat-clearing and detoxicating effervescence tablet preparation method comprises following process steps:
(1) ten two flavor medical material removes Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%～70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, get heat-clearing and toxic substances removing extract powder 1395g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity heat-clearing and toxic substances removing extractum fine powder 1395g and tartaric acid 1395g, sodium bicarbonate 1395g, A Sibapatan 56.25g, lactose 218.25g mixing, with dehydrated alcohol granulate, drying, add magnesium stearate 40.5g mixing, be pressed into 1000, promptly.
Embodiment 6
According to the shared umber of each raw material in the heat-clearing and detoxicating effervescence tablet, it is standby to get following recipe quantity raw material (by the gram number):
Gypsum Fibrosum 6700g Flos Lonicerae 1340g Radix Scrophulariae 1070g Radix Rehmanniae 800g Fructus Forsythiae 670g Fructus Gardeniae 670g
Herba Gueldenstaedtiae 670g Radix Scutellariae 670g Radix Gentianae 670g Radix Isatidis 670g Rhizoma Anemarrhenae 540g 540g Radix Ophiopogonis
The heat-clearing and detoxicating effervescence tablet preparation method comprises following process steps:
(1) ten two flavor medical material removes Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%～70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into and is determined as 1.25～1.30 thick paste under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, get heat-clearing and toxic substances removing extract powder 1455g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity heat-clearing and toxic substances removing extractum fine powder 1455g and tartaric acid 1455g, sodium bicarbonate 1455g, stevioside 67.5g, xylitol 36g mixing, with dehydrated alcohol granulate, drying, add PEG6000 31.5g mixing, be pressed into 1000, promptly.
Claims (3)
1, a kind of heat-clearing and detoxicating effervescence tablet is characterized in that this effervescent tablet is made up of following components in part by weight:
Heat-clearing and toxic substances removing extract powder, tartaric acid, sodium bicarbonate are 92-99 part altogether, heat-clearing and toxic substances removing extract powder: tartaric acid: sodium bicarbonate is 1: 1: 1, filler 0-5 part, lubricant 0.5-1 part, sweeting agent 0.5-2 part, the heat-clearing and toxic substances removing extract powder is made by the raw material of following weight parts:
Gypsum Fibrosum 10 Flos Loniceraes 2 Radix Scrophulariaes 1.6 Radix Rehmanniae 1.2 Fructus Forsythiaes 1 Fructus Gardeniae 1
0.8 Radix Ophiopogonis 0.8 of Herba Gueldenstaedtiae 1 Radix Scutellariae 1 Radix Gentianae 1 Radix Isatidis 1 Rhizoma Anemarrhenae
Preparation method is: above 12 flavor medical materials, remove Flos Lonicerae, outside the Radix Scutellariae, ten flavors such as all the other Gypsum Fibrosum add 10 times of water gaging warm macerating 1 hour earlier, decoct secondary, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, it is 1.17 that filtrate is concentrated into 60 ℃ of surveys of relative density, adds ethanol, makes to contain the alcohol amount and reach 65%-70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, filtrate is concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure, be ground into fine powder, promptly get the heat-clearing and toxic substances removing extract powder.
2, heat-clearing and detoxicating effervescence tablet according to claim 1, it is characterized in that sweeting agent is selected from a kind of of stevioside, betanin, Aspartane, filler is selected from a kind of in lactose, mannitol, the xylitol, and lubricant is selected from a kind of in polyethylene glycol 6000, Macrogol 4000, the magnesium stearate.
3, the preparation method of heat-clearing and detoxicating effervescence tablet according to claim 1 and 2 is characterized in that comprising following process steps:
The equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With heat-clearing and toxic substances removing extractum fine powder and tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, to granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
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| CNB2005100987226A CN1315514C (en) | 2005-09-07 | 2005-09-07 | Heat-clearing and detoxicating effervescence tablet and its preparing process |
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| CN102078584B (en) * | 2010-09-15 | 2011-11-30 | 姜光红 | Traditional Chinese medicine preparation for treating hot cold |
| CN104096204B (en) * | 2014-07-23 | 2017-10-13 | 重庆大学 | Lungs of Children coughs effervescent tablet and preparation method thereof |
| CN106072565A (en) * | 2016-07-03 | 2016-11-09 | 陈毅忠 | A kind of preparation method of lung moistening removing toxic substances effervescent tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1562314A (en) * | 2004-04-12 | 2005-01-12 | 张正生 | Effervesce tablet of reducing fever and detoxicating and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562314A (en) * | 2004-04-12 | 2005-01-12 | 张正生 | Effervesce tablet of reducing fever and detoxicating and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国药典2000年版第一部 国家药典委员会，592，化学工业出版社 2000 * |
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