CN100358493C - Chinese medica preparation for curing hyperplasia of mammary glands and preparation method - Google Patents
Chinese medica preparation for curing hyperplasia of mammary glands and preparation method Download PDFInfo
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- CN100358493C CN100358493C CNB2004100220718A CN200410022071A CN100358493C CN 100358493 C CN100358493 C CN 100358493C CN B2004100220718 A CNB2004100220718 A CN B2004100220718A CN 200410022071 A CN200410022071 A CN 200410022071A CN 100358493 C CN100358493 C CN 100358493C
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Abstract
The present invention relates to a traditional Chinese medicinal preparation for treating cyclomastopathy and a preparation method thereof. The traditional Chinese medicinal preparation for treating cyclomastopathy is prepared from stir-fried bupleurum root, stir-baked radix paeoniae alba, prepared rhizoma cyperi, figwort root, laminaria, snakegourd fruit, common selfheal fruit-spike, oyster shell, etc. The traditional Chinese medicinal preparation for treating cyclomastopathy has specific curative effect on cyclomastopathy; the tablet adopted by the present invention has accurate dosage, little content difference and stable quality, some medicines which are easy to oxidize and deliquesced can be coated for protection, and light, air, water, etc. have little influence on the tablet; the granule adopted by the present invention has little irritation to the gstrointestinal tract, large dosage, good mouth feel and easy acceptance; the oral liquid adopted by the present invention has rapid absorption, high bioavailability and wide range of users; the injection adopted by the present invention has high bioavailability, obvious effect, no first pass effect and suitability for patients without the capability of oral administration.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of cyclomastopathy and preparation method thereof, belong to the field of traditional Chinese medicine technology.
Technical background: cyclomastopathy and periodically disorder of hormone secretion or mammary gland tissue sensitivity increase relevant, are commonly encountered diseases, frequently-occurring disease.The applicant had once submitted " a kind of pharmaceutical composition for the treatment of cyclomastopathy and preparation method thereof " with employee comrade's Zhang Huifang name to Patent Office of the People's Republic of China, and application number is 02153458 patent application.In this part patent application document, pharmaceutical dosage form only is a capsule, and its content uniformity easily transfinites, and causes taking dose inaccurate; The stimulating gastrointestinal road; Moisture-sensitive, deliquescing, caking, even go mouldy, light, air, moisture etc. are bigger to its influence; Be difficult for swallowing, be difficult for accept, patient that can not oral drugs can't use, and application surface is little; Although so the medicine that this part application provides can be treated the disease of being narrated, the result of use of finding them in actual use is not special ideal.
Summary of the invention: Chinese medicine preparation of the treatment cyclomastopathy that the object of the invention is to provide a kind of evident in efficacy, taking convenience, have no side effect and preparation method thereof.
Technical solution of the present invention is achieved in that according to components by weight percent and calculates, to process 42～126 parts of Radix Bupleuri, 42～126 parts of Radix Paeoniae Alba (parched)s, 32～96 parts of prepared RHIZOMA CYPERIs, 42～126 parts of Radix Scrophulariaes, 53～158 parts of Thallus Laminariae (Thallus Eckloniae)s, 32～96 parts of Fructus Trichosanthis, 53～158 parts of Spica Prunellaes, 42～126 parts of Concha Ostreaes, 32～96 parts of Radix Angelicae Sinensis, 42～126 parts of Radix Ranunculi Ternatis, 32～96 parts of Radix Scutellariaes, 42～126 parts of Radix Salviae Miltiorrhizaes, 21～63 parts of Rhizoma Bolbostematiss, 11～32 parts of Pseudobulbus Cremastrae Seu Pleioness, 11～32 parts of Scorpios, Cortex Moutan is prepared into tablet for 42～126 parts, granule, soft capsule, oral liquid, drop pill, pill, medicated wine, tincture, extractum, ejection preparation, comprise: common injection, injectable powder, lyophilized injectable powder, infusion solution, other special preparations; Comprise sustained-release preparation, membranous patch, gel etc.Say accurately: its dosage form be tablet, granule, soft capsule, oral liquid,
Pill.Preparation method of the present invention is: gets Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, is ground into fine powder, and standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40～80% alcohol refluxs or heating extraction 2～3 times, each 1～3 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, and cold preservation 12～48 hours filters, filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, be blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, the reuse diverse ways is made different preparations.Its method for preparing tablet thereof is: gets Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, is ground into fine powder, and standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40～60% alcohol refluxs or heating extraction 2～3 times, each 1～2 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 1～2 hour for the first time 2～3 times, 0.5～1 hour for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, cold preservation 12～24 hours filters, and filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, and drying under reduced pressure, dried cream powder is broken, be blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, adding concentration is 3% carboxymethylcellulose sodium solution, granulates, tabletting, promptly.The method for making of its granule is to get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, is ground into fine powder, and is standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 60～80% alcohol refluxs or heating extraction 2～3 times, each 2～3 hours, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decoct with water 2～3 times, 2～3 hours for the first time, 1～2 hour for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 24～48 hours, filter, filtrate decompression concentrates, and adds above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, adding concentration is 3% carboxymethylcellulose sodium solution, granulates, promptly.The method for making of its pill be get Rhizoma Cyperi, Scorpio,
Cortex Moutan three flavors are ground into fine powder, and are standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40～80% alcohol refluxs or heating extraction 2～3 times, each 1～3 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 2～3 times, and 1～3 hour for the first time, 0.5～2 hour for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, and cold preservation 12～48 hours filters, filtrate decompression concentrates, and adds above-mentioned clear paste, and continues to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, add refined honey (relative density 1.37), pill, promptly
Among the present invention: Radix Bupleuri, the Radix Paeoniae Alba two medicines are monarch, the merit of long memorial liver resolving depression, yin fluid astringing and battalion, nourishing blood to suppress the hyperactive liver; With the circulation of qi promoting of Rhizoma Cyperi resolving depression, with Radix Scrophulariae, Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae removing heat-phlegm, hard masses softening and resolving, two groups of medicines are ministerial drug altogether, heighten the effect of a treatment with auxilliary monarch drug; Join Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Scorpio, Cortex Moutan blood circulation promoting and blood stasis dispelling, activating collaterals and eliminating stagnation, 5 Radix Ranunculi Ternati hard masses softening and resolving, the Radix Scutellariae liver heat removing is purged heat, and is adjuvant drug altogether, cooperates with the monarch drug Radix Paeoniae Alba and both can prevent just sending an expedition against wound, can go the temperature of Radix Ranunculi Ternati again, main to the greatest extent its usefulness.Add Rhizoma Bolbostematis, Pseudobulbus Cremastrae Seu Pleiones, the special medicine of Concha Ostreae hard masses softening and resolving, with being messenger drug.All medicines share, and play altogether and attack its disease, its enclosed mass that looses, and dredging the meridian is changed the merit of its expectorant stasis of blood, and proper combination of syndromes machine is so clinical efficacy is remarkable.Tablet, granule, soft capsule, oral liquid, drop pill, pill etc. are selected in invention for use; Tablet dose is accurate, and the content content difference is little, steady quality, and some easy oxidation deterioration and deliquescent medicine can be protected by coating, and light, air, moisture etc. are less to its influence; Granule, GI irritation is little; Drug loading is big, and mouthfeel is good, is beneficial to acceptance; Oral liquid absorbs fast, the bioavailability height, and the use crowd is wide; Injection bioavailability height, onset speed is fast, no first pass effect, be applicable to can not be oral the patient; Sustained-release preparation is easy to use, provides balance persistent effective blood drug concentration, needing to be particularly useful for the patient of long-term prescription.The present invention has more definite therapeutic effect for cyclomastopathy.
Effectively controlled in order to confirm method provided by the invention, the preparation good effect, the applicant carries out a series of experiments:
Experimental example 1: the prevention administration is to the effect of cyclomastopathy
Get 50 of female rats, be divided into 5 groups at random, be respectively blank group, capsule matched group, test granule group, test oral liquid group and positive control drug group by body weight.Animal is surgical removal bilateral ovaries behind etherization in advance.Postoperative rose on the 4th day, and lumbar injection estrogen continuous 25 days, gave progestogen subsequently again and caused hyperplasia of mammary gland model every day.Make film simultaneously, what give oral various dose is subjected to reagent thing or control drug.Observe outgrowth incidence rate of animal's mammary gland and pathologic finding situation.The result, the preventative animal that gives medicine of the present invention in female, the progestogen of injection, the cyclomastopathy incidence rate all significantly reduces, the nipple redness of pathologic finding gross examination of skeletal muscle, mammary gland increases and the hypertrophy of microexamination lobule, acinus and conduit, also obviously alleviate, similar to the matched group effect, show that pharmaceutical composition of the present invention has the effect of treatment cyclomastopathy.
Experimental example 2: to the therapeutical effect of blood stasis model due to the rabbit dextran
Healthy female rabbit, auricular vein are injected 10% dextran 5ml/kg, every day 2 times, and continuous 2 days, cause the blood stasis model, measure last and inject back 15 minutes animal blood viscosities.Same animal begins oral administration gavage granule of the present invention or oral liquid after 1 week, continuous 5 days, dextran was injected in administration in the 4th and 5 day again after 30 minutes, and method is the same, measures back 15 minutes animal blood viscosities of injection.The result shows, pharmaceutical composition of the present invention has whole blood viscosity and the plasma viscosity effect of animal due to the remarkable reduction high molecular dextran.This results suggest preparation of the present invention has certain blood circulation-promoting functions.
Experimental example 3: the screening of adjuvant
Selecting suitable adjuvant in the present patent application for use is one of key technology of the various different dosage forms of preparation; Because adjuvant has bigger influence to various different dosage forms; Select the improper preparation and the end product quality that can influence product.
With 50 of different auxiliary material compactings, check the sheet number that goes wrong in the tabletting process
| Tablet | Adjuvant | ||||||||
| Gelatine size | Polyethylene Glycol | Sodium carboxymethyl cellulose | |||||||
| Concentration pine sheet sticking sliver | 1％ 4 3 4 | 3％ 6 5 7 | 5％ 6 5 8 | 1％ 4 8 6 | 5％ 7 5 6 | 10％ 8 6 7 | 1％ 3 11 3 | 3％ 1 1 2 | 5％ 4 3 5 |
Determination of water: get test sample 5g, be tiled in the flat type weighing bottle that is dried to constant weight, the accurate title, decide, open bottle cap 105 ℃ of dryings 5 hours, bottle cap is built, in the dislocation exsiccator, cooled off 30 minutes, accurate claim decide weight, dry 1 hour of said temperature, cool off again, weigh, extremely double difference of weighing is no more than till the 5mg, according to the weight that subtracts mistake, calculates the moisture percentage that contains.
Granularity is checked: get 5 bags of granules, claim decide weight, put in the medicine sieve and sieve, when sieving, will sieve and keep level, about come and go and sieved gently 3 minutes, can not be by a sieve and can pass through the granule and the powder summation of sieving for No. four.
| Granule | Adjuvant | ||||||||
| Gelatine size | Polyethylene Glycol | Sodium carboxymethyl cellulose | |||||||
| Concentration % moisture % granularity % | 1 8 9 | 3 7 7 | 5 6 6 | 1 9 8 | 5 9 7 | 10 7 8 | 1 4 8 | 3 3 5 | 5 6 9 |
By experiment, adopt the selected adjuvant prepared preparation steady quality of the present invention, good effect.
Concrete embodiment:
Embodiments of the invention 1:
Get and process 42 parts of Radix Bupleuri, 42 parts of Radix Paeoniae Alba (parched)s, 32 parts of prepared RHIZOMA CYPERIs, 42 parts of Radix Scrophulariaes, 53 parts of Thallus Laminariae (Thallus Eckloniae)s, 32 parts of Fructus Trichosanthis, 53 parts of Spica Prunellaes, 42 parts of Concha Ostreaes, 32 parts of Radix Angelicae Sinensis, 42 parts of Radix Ranunculi Ternatis, 32 parts of Radix Scutellariaes, 42 parts of Radix Salviae Miltiorrhizaes, 21 parts of Rhizoma Bolbostematiss, 11 parts of Pseudobulbus Cremastrae Seu Pleioness, 11 parts of Scorpios, 42 parts of Cortex Moutans, get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40% alcohol reflux 2～3 times, each 1 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 1 hour for the first time 2～3 times, 0.5 hour for the second time, filter, filtrate merges, concentrating under reduced pressure, gained clear paste add ethanol to be made and contains alcohol amount and reach 50%, cold preservation 12 hours, filter, filtrate decompression concentrates, and adds above-mentioned clear paste, and continues to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, adding concentration is 3% carboxymethylcellulose sodium solution, granulate, tabletting promptly gets tablet, oral, every day 3 times, each 3.
Embodiments of the invention 2:
Get and process 126 parts of Radix Bupleuri, 126 parts of Radix Paeoniae Alba (parched)s, 96 parts of prepared RHIZOMA CYPERIs, 126 parts of Radix Scrophulariaes, 158 parts of Thallus Laminariae (Thallus Eckloniae)s, 96 parts of Fructus Trichosanthis, 158 parts of Spica Prunellaes, 126 parts of Concha Ostreaes, 96 parts of Radix Angelicae Sinensis, 126 parts of Radix Ranunculi Ternatis, 96 parts of Radix Scutellariaes, 126 parts of Radix Salviae Miltiorrhizaes, 63 parts of Rhizoma Bolbostematiss, 32 parts of Pseudobulbus Cremastrae Seu Pleioness, 32 parts of Scorpios, 126 parts of Cortex Moutans, get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 80% alcohol reflux 2～3 times, each 3 hours, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decoct with water 2～3 times, 3 hours for the first time, 2 hours for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 48 hours, filter, filtrate decompression concentrates, and adds above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, adding concentration is 3% carboxymethylcellulose sodium solution, granulates, and promptly gets granule.
Embodiments of the invention 3: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans, get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40% ethanol heating extraction 2～3 times, each 1 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 2～3 times, and 1 hour for the first time, 0.5 hour for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, and cold preservation 12 hours filters, filtrate decompression concentrates, and adds above-mentioned clear paste, and continues to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, add vegetable oil 500g, pill, promptly
Embodiments of the invention 4: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans, get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 80% ethanol heating extraction 3 times, each 3 hours, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 2～3 times, and 3 hours for the first time, 2 hours for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, and cold preservation 48 hours filters, filtrate decompression concentrates, and adds above-mentioned clear paste, and continues to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, add refined honey, pill, promptly.
Claims (2)
1, a kind of Chinese medicine preparation for the treatment of cyclomastopathy is characterized in that it makes by the following method: get and process 42～126 parts of Radix Bupleuri, 42～126 parts of Radix Paeoniae Alba (parched)s, 32～96 parts of prepared RHIZOMA CYPERIs, 42～126 parts of Radix Scrophulariaes, 53～158 parts of Thallus Laminariae (Thallus Eckloniae)s, 32～96 parts of Fructus Trichosanthis, 53～158 parts of Spica Prunellaes, 42～126 parts of Concha Ostreaes, 32～96 parts of Radix Angelicae Sinensis, 42～126 parts of Radix Ranunculi Ternatis, 32～96 parts of Radix Scutellariaes, 42～126 parts of Radix Salviae Miltiorrhizaes, 21～63 parts of Rhizoma Bolbostematiss, 11～32 parts of Pseudobulbus Cremastrae Seu Pleioness, 11～32 parts of Scorpios, 42～126 parts of Cortex Moutans; Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors are ground into fine powder, and are standby; Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes add 40～80% alcohol refluxs or heating extraction 2～3 times, and each 1～3 hour, filter, filtrate decompression concentrates, and clear paste is standby; Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 12～48 hours, filter, filtrate decompression concentrates, and adds above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, adding concentration is 3% carboxymethylcellulose sodium solution, granulates, and promptly gets granule; Or tabletting, promptly get tablet.
2, the preparation method of the Chinese medicine preparation of treatment cyclomastopathy as claimed in claim 1 is characterized in that: get and process 42～126 parts of Radix Bupleuri, 42～126 parts of Radix Paeoniae Alba (parched)s, 32～96 parts of prepared RHIZOMA CYPERIs, 42～126 parts of Radix Scrophulariaes, 53～158 parts of Thallus Laminariae (Thallus Eckloniae)s, 32～96 parts of Fructus Trichosanthis, 53～158 parts of Spica Prunellaes, 42～126 parts of Concha Ostreaes, 32～96 parts of Radix Angelicae Sinensis, 42～126 parts of Radix Ranunculi Ternatis, 32～96 parts of Radix Scutellariaes, 42～126 parts of Radix Salviae Miltiorrhizaes, 21～63 parts of Rhizoma Bolbostematiss, 11～32 parts of Pseudobulbus Cremastrae Seu Pleioness, 11～32 parts of Scorpios, 42～126 parts of Cortex Moutans; Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors are ground into fine powder, and are standby; Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes add 40～80% alcohol refluxs or heating extraction 2～3 times, and each 1～3 hour, filter, filtrate decompression concentrates, and clear paste is standby; Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decoct with water 2～3 times, 1～3 hour for the first time, 0.5～2 hour for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 12～48 hours, filter, filtrate decompression concentrates, and adds above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, adding concentration is 3% carboxymethylcellulose sodium solution, granulates, and promptly gets granule; Or tabletting, promptly get tablet.
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| CN100352483C (en) * | 2005-04-28 | 2007-12-05 | 李建柱 | Externally applied medicine for treating mammary glands hyperplasia and preventing mammary cancer |
| CN100391480C (en) * | 2006-05-31 | 2008-06-04 | 武汉市海格尔科技有限公司 | Hydrophilic gel pleximetric paste and its preparation |
| CN101244177B (en) * | 2008-03-21 | 2010-06-23 | 朱霞 | Rupisan medicine and preparation thereof |
| CN101342357B (en) * | 2008-09-08 | 2010-12-29 | 杜彦秋 | Chinese medicinal composition for treating gland hyperplasia and preventing and controlling mammary cancer |
| CN102319360B (en) * | 2011-09-23 | 2013-07-17 | 陕西步长高新制药有限公司 | Traditional Chinese medicine composition used for treating mammary gland hyperplasia, and preparation method thereof |
| CN102319361B (en) * | 2011-09-23 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN102319362B (en) * | 2011-09-23 | 2013-04-10 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN103142852A (en) * | 2011-11-01 | 2013-06-12 | 邓永峰 | Pharmaceutical composition for treating breast hyperplasia and method for preparing same |
| CN102716296A (en) * | 2012-06-24 | 2012-10-10 | 李延玲 | Breast nodule pill |
| CN105381122A (en) * | 2015-11-30 | 2016-03-09 | 潘素荣 | Hard lump-resolving preparation for treating hyperplasia of mammary glands and preparation method for hard lump-resolving preparation |
| CN105288503A (en) * | 2015-12-03 | 2016-02-03 | 苏州枫灵医药科技有限公司 | Pharmaceutic preparation for treating nodules of breasts |
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| CN1418683A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine composition for treating mammary gland proliferation, and its prepn. method |
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