CN100342848C - Effervescence tablet for reducing fever comprising tropaeolum and process for preparing the same - Google Patents
Effervescence tablet for reducing fever comprising tropaeolum and process for preparing the same Download PDFInfo
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- CN100342848C CN100342848C CNB200510098725XA CN200510098725A CN100342848C CN 100342848 C CN100342848 C CN 100342848C CN B200510098725X A CNB200510098725X A CN B200510098725XA CN 200510098725 A CN200510098725 A CN 200510098725A CN 100342848 C CN100342848 C CN 100342848C
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Abstract
The present invention relates to a tropaeolum fever reduction effervescence tablet and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The effervescence tablet is composed of a tropaeolum fever reduction powdered extract, an acid agent, an alkaline agent, a sweetening agent, a filling agent and a lubricant agent. The present invention has the advantages of rational matching of the kinds and the dosage of auxiliary materials and basic remedies, simple preparation process, stable quality of the effervescence tablet, and favorable effect of effervescence. The present invention relates to a tropaeolum fever reduction effervescence tablet and a preparation method thereof having the characteristics of high bioavailability, fast effect taking, convenient taking, stable quality, good mouth feel and convenient transportation and carrying.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, more specifically relate to a kind of effervescence tablet for reducing fever comprising tropaeolum and preparation method thereof.
Background technology
Mouthfeel was bad when JINLIAN QINGRE KELI was taken, and carried also inconvenient.And after agent changes effervescence tablet for reducing fever comprising tropaeolum into, volume is little, and directly take after the dissolving of hot water effervescent, delicious taste, compare with granule, promptly inherited the advantage of oral good absorbing behind the water dissolution, improved the relatively poor characteristic of mouthfeel behind the big and water dissolution of particle volume again, storage and transportation are also more convenient, meet the modern requirement of Chinese medicine preparation.The oral administration effervescing sheet is to be the novel quick-release tablet of disintegrating agent with the effervescent, both having, but effervescent is dissolved in hot water, but effervescent is dissolved in the advantage of directly taking behind the cold water again, onset is rapid, bioavailability is high, and mouthfeel is good, be suitable for child especially, the old man takes, and has vast market prospect.Chinese medicine effervescent tablet Chinese medicine extractum proportion is very big, difficult point is the selection of drug extract powder and pharmaceutic adjuvant kind and ratio, selected proper supplementary material and appropriate ratio, can reduce supplementary product consumption, preparation technology is simple, easy-formation, be difficult for moisture absorption, effervescent speed is fast, and effervescent is effective, medicinal liquid clarity is good behind the effervescent, no granule.
Summary of the invention
For solving not easy-formation of Chinese medicine effervescent tablet, disintegrate is slow, and clarity is bad, and problems such as poor stability the invention provides a kind of principal agent, supplementary product kind reasonable mixture ratio, forming, good stability, effervescence tablet for reducing fever comprising tropaeolum that clarity is good after the disintegrate and preparation method thereof.
The present invention is implemented by the following technical programs.
A kind of effervescence tablet for reducing fever comprising tropaeolum of the present invention, it is made up of reducing fever comprising tropaeolum extract powder, tartaric acid, sodium bicarbonate, sweeting agent, filler, lubricant, and each component umber is:
Reducing fever comprising tropaeolum extract powder, tartaric acid, sodium bicarbonate be 92-96 part altogether, lubricant 0.5-1 part, and sweeting agent 0.5-2 part,
Filler 3-5 part, wherein reducing fever comprising tropaeolum extract powder: tartaric acid: sodium bicarbonate is 9: 8: 8.
Wherein said reducing fever comprising tropaeolum extract powder is made by following raw materials in parts by weight.
Flos Trollii 2 Folium Isatidiss, 2 Gypsum Fibrosum (life) 1.5 Rhizoma Anemarrhenaes 1 Radix Rehmanniae 1
Radix Scrophulariae 1 Semen Armeniacae Amarum (stir-fry) 1.5.
Sweeting agent is selected from a kind of in stevioside, betanin, the Aspartane, is preferably Aspartane; Filler is selected from a kind of in lactose, mannitol, the xylitol, is preferably mannitol, xylitol; Lubricant is selected from a kind of in PEG6000, PEG4000, the magnesium stearate.
Its preparation method can be mainly to comprise following process steps:
(1) seven flavor Chinese medicines such as Flos Trollii decoct with water secondary, add 7～8 times of water gagings for the first time, decoct 2 hours; For the second time add 5～6 times of water gagings, decocted 1 hour, collecting decoction filters, and it is 1.05～1.40 clear paste that filtrate decompression is concentrated into 50 ℃ of heat surveys of relative density, and vacuum drying is ground into fine powder, promptly gets the reducing fever comprising tropaeolum extract powder.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With reducing fever comprising tropaeolum extractum fine powder and tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, to granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.Umber by above-mentioned each component of effervescent tablet carries out proportion optimization, to determine optimum formula.Filler is used for adjustment sheet heavily, and sweeting agent is used for improving mouthfeel, and lubricant plays fluidizer and lubrication when tabletting.
Below be effervescence tablet for reducing fever comprising tropaeolum prescription screening experiment:
One, the selection of sour agent and alkaline agent
In the selection of effervescent, sodium bicarbonate is as alkali source, and consumption is few, and gas production is big, and the present invention adopts sodium bicarbonate as alkali source.Because the easy moisture absorption of Chinese medical concrete powder, viscosity is big, so the selection of acid source is very important.Take by weighing a certain amount of medicated powder and mix evenly, granulate, carry out different preparations shaping prescriptions and screen, the results are shown in Table 1 with dehydrated alcohol with acid, alkali.
The screening of the different preparations shaping soda acid of table 1 prescription
| The prescription number | Medicated powder (g) | Acid kind (g) | Alkali kind (g) | The result |
| 1 2 3 4 5 6 | 14 14 14 14 14 14 | Tartaric acid 12 adipic acids 12 succinic acid 12 malic acids 12 fumaric acid 12 citric acids 12 | Sodium bicarbonate 12 sodium bicarbonate 12 sodium bicarbonate 12 sodium bicarbonate 12 sodium bicarbonate 12 sodium bicarbonate 12 | The all good effervescent of granulation, tabletting, effervescent is too slow, the bad moisture absorption of effect, the moisture absorption of can't granulating, can't granulate better, effervescent lumps slowly, can't granulate |
The result shows: the effect of prescription 1 is better, and promptly effervescent selects tartaric acid as acid source, and sodium bicarbonate is as alkali source.
Two, medicated powder, the screening of effervescent proportioning
To effervescent tablet quality influence maximum in the Chinese medicine effervescent tablet is soda acid ratio in effervescent and drug ratios and the effervescent, be screening formula, based on above-mentioned prescription 1, be factor in soda acid ratio in the ratio of shared weight of effervescent and the effervescent, do 4 horizontal comprehensive tests.
Test method: get the not commensurability medicated powder and the soda acid of different proportionings (the prescription total amount is 25g) respectively, evenly mixed, granulate with dehydrated alcohol, drying, tabletting the results are shown in Table 2.
Table 2 medicated powder, effervescent proportioning screening table
| Sequence number | Medicated powder accounts for sheet anharmonic ratio example | Effervescent accounts for sheet anharmonic ratio example | Acid accounts for the effervescent ratio | The effervescent effect | Disintegration time |
| 1 2 3 4 5 6 7 8 9 10 11 12 | 9/25 9/25 9/25 9/25 1/2 1/2 1/2 1/2 2/3 2/3 2/3 2/3 | 16/25 16/25 16/25 16/25 1/2 1/2 1/2 1/2 1/3 1/3 1/3 1/3 | 40％ 45％ 50％ 55％ 40％ 45％ 50％ 55％ 40％ 45％ 50％ 55％ | +++ +++ ++++ ++++ +++ +++ ++ ++ + + + + | 1 minute 13 seconds 1 minute 17 seconds 1 minute 22 seconds 1 minute 48 seconds 4 minutes 33 seconds 4 minutes 38 seconds 4 minutes 50 seconds 4 minutes 52 seconds 55 minutes 61 minutes 64 minutes 68 minutes |
It is comprehensive that relatively the effervescent effect is better with 3,4,5,6,7,8 also can, 3,4 is moderate, 5,6 a little less than, 1,2 gas releases are too big, further grope so choosing is filled a prescription to 3,4.
Three, effervescent consumption screening
Know according to above-mentioned result of the test, effervescent tablet of the present invention is promptly plastic without filler, different batches Chinese crude drug paste-forming rate is variant in considering to produce, need there be 3-5% filler space to regulate total amount, simultaneously for improving mouthfeel, the sweeting agent that can add 0.5-2%, particulate flowability when increasing tabletting can add the lubricant of 0.5-1%.
Test method: every group of test all feeds intake by 100, take by weighing prescription dried cream powder 135g, add not commensurability tartaric acid, sodium bicarbonate and an amount of filler, sweeting agent mixing, with dehydrated alcohol granulation, drying, add lubricant, mixing, tabletting, every heavy 4.0g/ sheet the results are shown in following table, the consumption during the consumption of table Chinese medicine powder, acid, alkali is every.
Table 3 effervescent consumption screening table
| Sequence number | Medicated powder (g) | Acid (g) | Alkali (g) | Disintegration time | Medicinal liquid evaluation behind the effervescent |
| 1234 | 1.35 1.35 1.35 1.35 | 1.14 1.20 1.26 1.32 | 1.26 1.20 1.14 1.08 | 2 minutes 1 minute 20 seconds 2 minutes 3 seconds 2 minutes 9 seconds | Medicinal liquid has a small amount of floccule, and mouthfeel is poor.The medicinal liquid clarification, mouthfeel is good.Medicinal liquid is muddy slightly, and mouthfeel is general.Some muddiness of medicinal liquid, mouthfeel is general. |
Table 3 result of the test shows that the optimal proportion of prescription Chinese medicine powder and tartaric acid, sodium bicarbonate is 9: 8: 8.
Four, preparation stabilization Journal of Sex Research
In order to investigate the stability of moulding process, we place 40 ℃, relative humidity with the effervescent tablet of two aluminum laminated films packings is 75% climatic chamber, places 1 month, takes out, and appearance character, effervescent time of measuring its test front and back the results are shown in Table 4.
Comparing result before and after table 4 accelerated test
| Sample | Appearance character | The effervescent time |
| After testing before the test | The drabon color chips agent of drabon color chips agent | 1 minute 15 seconds 1 minute 22 seconds |
The result shows: this medicine has no significant change at aspects such as appearance color, physical behavior, effervescent times before and after the accelerated test, illustrates that this medicine is basicly stable, and moulding process is reasonable.
It is reasonable that effervescence tablet for reducing fever comprising tropaeolum principal agent of the present invention, adjuvant are formed with the proportioning selection, and effervescent is effective, and medicinal liquid clarity is good behind the effervescent.The effervescence tablet for reducing fever comprising tropaeolum preparation technology who makes by the present invention is simple, steady quality.
The specific embodiment
The present invention is described further by embodiment
Embodiment 1
Take off and state raw material for standby:
Flos Trollii 1500g Folium Isatidis 1500g Gypsum Fibrosum (life) 1125g Rhizoma Anemarrhenae 750g Radix Rehmanniae 750g
Radix Scrophulariae 750g Semen Armeniacae Amarum (stir-fry) 1125g
The effervescence tablet for reducing fever comprising tropaeolum preparation method comprises following process steps:
(1) seven flavor Chinese medicines such as Flos Trollii decoct with water secondary, add 7～8 times of water gagings for the first time, decoct 2 hours; For the second time add 5～6 times of water gagings, decocted 1 hour, collecting decoction filters, and it is 1.05～1.40 clear paste that filtrate decompression is concentrated into 50 ℃ of heat surveys of relative density, and vacuum drying is ground into fine powder, promptly gets reducing fever comprising tropaeolum extract powder 1325.25g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity reducing fever comprising tropaeolum extractum fine powder 1325.25g and tartaric acid 1178g, sodium bicarbonate 1178g, A Sibapatan 80g, xylitol 200g mixing, with dehydrated alcohol granulate, drying, add PEG4000 39.75g mixing, be pressed into 1000, promptly.
Embodiment 2
Take off and state raw material for standby:
Flos Trollii 1500g Folium Isatidis 1500g Gypsum Fibrosum (life) 1125g Rhizoma Anemarrhenae 750g Radix Rehmanniae 750g
Radix Scrophulariae 750g Semen Armeniacae Amarum (stir-fry) 1125g
The effervescence tablet for reducing fever comprising tropaeolum preparation method comprises following process steps:
(1) seven flavor Chinese medicines such as Flos Trollii decoct with water secondary, add 7～8 times of water gagings for the first time, decoct 2 hours; For the second time add 5～6 times of water gagings, decocted 1 hour, collecting decoction filters, and it is 1.05～1.40 clear paste that filtrate decompression is concentrated into 50 ℃ of heat surveys of relative density, and vacuum drying is ground into fine powder, promptly gets reducing fever comprising tropaeolum extract powder 1382.4g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity reducing fever comprising tropaeolum extractum fine powder 1382.4g and tartaric acid 1228.8g, sodium bicarbonate 1228.8g, betanin 20g, lactose 120g mixing, with dehydrated alcohol granulate, drying, add PEG6000 20g mixing, be pressed into 1000, promptly.
Embodiment 3
Take off and state raw material for standby:
Flos Trollii 1500g Folium Isatidis 1500g Gypsum Fibrosum (life) 1125g Rhizoma Anemarrhenae 750g Radix Rehmanniae 750g
Radix Scrophulariae 750g Semen Armeniacae Amarum (stir-fry) 1125g
The effervescence tablet for reducing fever comprising tropaeolum preparation method comprises following process steps:
(1) seven flavor Chinese medicines such as Flos Trollii decoct with water secondary, add 7～8 times of water gagings for the first time, decoct 2 hours; For the second time add 5～6 times of water gagings, decocted 1 hour, collecting decoction filters, and it is 1.05～1.40 clear paste that filtrate decompression is concentrated into 50 ℃ of heat surveys of relative density, and vacuum drying is ground into fine powder, promptly gets reducing fever comprising tropaeolum extract powder 1350g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity reducing fever comprising tropaeolum extractum fine powder 1350g and tartaric acid 1200g, sodium bicarbonate 1200g, stevioside 60g, mannitol 150g mixing, with dehydrated alcohol granulate, drying, add magnesium stearate 40g mixing, be pressed into 1000, promptly.
Embodiment 4
Take off and state raw material for standby:
Flos Trollii 1500g Folium Isatidis 1500g Gypsum Fibrosum (life) 1125g Rhizoma Anemarrhenae 750g Radix Rehmanniae 750g
Radix Scrophulariae 750g Semen Armeniacae Amarum (stir-fry) 1125g
The effervescence tablet for reducing fever comprising tropaeolum preparation method comprises following process steps:
(1) seven flavor Chinese medicines such as Flos Trollii decoct with water secondary, add 7～8 times of water gagings for the first time, decoct 2 hours; For the second time add 5～6 times of water gagings, decocted 1 hour, collecting decoction filters, and it is 1.05～1.40 clear paste that filtrate decompression is concentrated into 50 ℃ of heat surveys of relative density, and vacuum drying is ground into fine powder, promptly gets reducing fever comprising tropaeolum extract powder 1368g.
(2) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With recipe quantity reducing fever comprising tropaeolum extractum fine powder 1368g and tartaric acid 1216g, sodium bicarbonate 12168, stevioside 33g, mannitol 1428 mixings, with dehydrated alcohol granulate, drying, add PEG4000 25g mixing, be pressed into 1000, promptly.
Claims (3)
1, a kind of effervescence tablet for reducing fever comprising tropaeolum is characterized in that this effervescent tablet is made up of following components by part by weight:
Reducing fever comprising tropaeolum extract powder, tartaric acid, sodium bicarbonate be 92-96 part altogether, lubricant 0.5-1 part, sweeting agent 0.5-2 part, filler 3-5 part, reducing fever comprising tropaeolum extract powder wherein: tartaric acid: sodium bicarbonate is 9: 8: 8, and wherein said reducing fever comprising tropaeolum extract powder is made by following method:
Flos Trollii 2 Folium Isatidiss 2 Gypsum Fibrosum 1.5 Rhizoma Anemarrhenaes 1 Radix Rehmanniae 1 Radix Scrophulariae 1 Semen Armeniacae Amarum (parched) 1.5;
Seven flavor Chinese medicines such as Flos Trollii decoct with water secondary, add 7～8 times of water gagings for the first time, decoct 2 hours; For the second time add 5～6 times of water gagings, decocted 1 hour, collecting decoction filters, and it is 1.05～1.40 clear paste that filtrate decompression is concentrated into 50 ℃ of heat surveys of relative density, and vacuum drying is ground into fine powder, promptly gets the reducing fever comprising tropaeolum extract powder.
2, effervescence tablet for reducing fever comprising tropaeolum according to claim 1, sweeting agent is selected from a kind of in stevioside, betanin, the Aspartane, filler is selected from a kind of in lactose, mannitol, the xylitol, and lubricant is selected from a kind of in PEG6000, PEG4000, the magnesium stearate.
3, according to the preparation method of the effervescence tablet for reducing fever comprising tropaeolum of claim 1 or 2, it is characterized in that comprising following process steps:
The equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With reducing fever comprising tropaeolum extractum fine powder and tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, to granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
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| CN106387915B (en) * | 2016-11-23 | 2021-12-28 | 宁夏五行科技有限公司 | Qi and coffee vigor-benefiting effervescent tablet and preparation process and application thereof |
| CN106420656B (en) * | 2016-11-25 | 2018-10-02 | 广东大鹏医药科技有限公司 | A kind of trollflower effervescent tablet and preparation method thereof |
| CN109588605A (en) * | 2018-11-26 | 2019-04-09 | 安徽迎春草生物科技有限公司 | A kind of heat-clearing is welcomed spring careless effervescent tablet and preparation method thereof |
| CN109464582A (en) * | 2018-12-11 | 2019-03-15 | 李天� | A kind of lily feet flower health care wine and preparation method thereof |
| CN109337780A (en) * | 2018-12-11 | 2019-02-15 | 李天� | A kind of lily feet flower health care wine and its brewing method |
| CN111467423B (en) * | 2020-05-15 | 2021-11-30 | 贵州益佰制药股份有限公司 | Honeysuckle flower and lotus root heat-clearing spray and preparation method thereof |
| CN111544512A (en) * | 2020-05-15 | 2020-08-18 | 贵州益佰制药股份有限公司 | Heat-clearing anus suppository containing flos Trollii and preparation method thereof |
| CN113750173A (en) * | 2020-06-05 | 2021-12-07 | 贵州益佰制药股份有限公司 | Application of flos Trollii heat clearing preparation in treating infectious mononucleosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1460513A (en) * | 2003-06-11 | 2003-12-10 | 宁夏启元药业有限公司 | Jinlian Qingre capsule and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1460513A (en) * | 2003-06-11 | 2003-12-10 | 宁夏启元药业有限公司 | Jinlian Qingre capsule and its preparation method |
Non-Patent Citations (1)
| Title |
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| 中华人民共和国药典委员会 中华人民人和国卫生部药口标准中药成方制剂，第12期 1996 * |
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Denomination of invention: Effervescence tablet for reducing fever comprising tropaeolum and process for preparing the same Effective date of registration: 20140821 Granted publication date: 20071017 Pledgee: Bank of Shanghai Limited by Share Ltd Tianjin branch Pledgor: TIANJIN HORUS C&K PHARMACEUTICAL CO., LTD. Registration number: 2014120000046 |
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| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20151215 Granted publication date: 20071017 Pledgee: Bank of Shanghai Limited by Share Ltd Tianjin branch Pledgor: TIANJIN HORUS C&K PHARMACEUTICAL CO., LTD. Registration number: 2014120000046 |
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| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model |