CN103191166B - Improve the method for Saus-surea obvallata (DC.) Edgew yield and the application of extract and this extract - Google Patents
Improve the method for Saus-surea obvallata (DC.) Edgew yield and the application of extract and this extract Download PDFInfo
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- CN103191166B CN103191166B CN201310113712.XA CN201310113712A CN103191166B CN 103191166 B CN103191166 B CN 103191166B CN 201310113712 A CN201310113712 A CN 201310113712A CN 103191166 B CN103191166 B CN 103191166B
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Abstract
The invention belongs to Effective Component of Chinese Medicine position and extracting method, and this Effective Component of Chinese Medicine position is can application in sanatory pharmaceutical preparation.Extracting method step comprises pretreatment; Steam explosion treatment; Backflow lixiviate; Concentrate drying extract, obtains Saus-surea obvallata (DC.) Edgew extract.The present invention also comprise make an addition to Saus-surea obvallata (DC.) Edgew by the weight ratio of described Saus-surea obvallata (DC.) Edgew extract 20%-50% can in sanatory pharmaceutical preparation.The beneficial effect that the present invention has is: adopt steam explosion technology to impel effective ingredient in Saus-surea obvallata (DC.) Edgew fully to leach, extract yield can reach 20-50%, and the Saus-surea obvallata (DC.) Edgew of resource scarcity is maximized the use; On drying means, while extract drying, add adjuvant, the adhesive effect of extract after adjuvant mixes with extract, can be reduced, and increase volume and make moisture Quick diffusing, make extract thoroughly dry, shorten drying time, the extract obtained the not easily moisture absorption, easily preserves.
Description
Technical field
The invention belongs to Effective Component of Chinese Medicine position and extracting method, and this Effective Component of Chinese Medicine position at this Effective Component of Chinese Medicine position can application in sanatory pharmaceutical preparation.
Background technology
At present, conventional method is adopted to the extraction of Saus-surea obvallata (DC.) Edgew, as: the Saus-surea obvallata (DC.) Edgew after drying and crushing is added the alcoholic solution heating extraction of 50% several times, last merge extractive liquid, is concentrated obtains extractum, spraying dry, obtains extract.Extract Saus-surea obvallata (DC.) Edgew in this way, its yield low (only 1-20%), waste is large, and the dry difficulty of extract is large, and the time is long, and cost is high, and the easy moisture absorption, is difficult to ensure and deposits.
Summary of the invention
The problem to be solved in the present invention is exactly provide a kind of method improving the effective component extracts yield of Saus-surea obvallata (DC.) Edgew for above deficiency, and the Saus-surea obvallata (DC.) Edgew extract in this way obtained, also have this extract can application in sanatory pharmaceutical preparation at Saus-surea obvallata (DC.) Edgew.Its technical scheme is as follows:
Extracting method comprises the following steps:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.8-2MPa after steam explosion 4-6 minute, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the extraction solvent lixiviate 2-3 time Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 8-12 times amount, each extraction 2-3 hour, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa at temperature 55-65 DEG C, to concentrate extract to density be the extractum of 1.01-1.1, then 50-70 DEG C of dry 12-48 hour after the adjuvant mixing adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Described Saus-surea obvallata (DC.) Edgew extract, comprises the following steps obtained:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.8-2MPa after steam explosion 4-6 minute, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the extraction solvent lixiviate 2-3 time Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 8-12 times amount, each extraction 2-3 hour, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa at temperature 55-65 DEG C, to concentrate extract to density be the extractum of 1.01-1.1, then 50-70 DEG C of dry 12-48 hour after the adjuvant mixing adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
The present invention also provides above-mentioned Saus-surea obvallata (DC.) Edgew extract can treat application in disorder agent preparing Saus-surea obvallata (DC.) Edgew.Making an addition to Saus-surea obvallata (DC.) Edgew by the weight ratio of described Saus-surea obvallata (DC.) Edgew extract 20%-50% can in sanatory pharmaceutical preparation.
Because Saus-surea obvallata (DC.) Edgew nature and flavor are sweet, bitter, warm, enter liver,spleen,kidney three warp, have kidney invigorating and YANG supporting, regulating menstruation, hemostasis, removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation to restore menstrual flow network, effect of blood stasis dispelling.The extract of gained can be used for the kidney invigorating, menstruction regulating and pain relieving, anti-inflammation, in treatment rheumatism, the disease such as to restore menstrual flow and invigorate blood circulation.Saus-surea obvallata (DC.) Edgew extract feeds intake by national standard prescription consumption, carry out single or be equipped with after other medical material compound recipes corresponding coordinate, being prepared into various preparation if pill, tablet, granule, capsule, drop pill, syrup etc. are for the treatment of above-mentioned disease.
Compared with prior art, the beneficial effect that the present invention has is:
1, adopt steam explosion technology to impel effective ingredient in Saus-surea obvallata (DC.) Edgew fully to leach, extract yield can reach 20-50%, is much higher than traditional extraction yield 1-20%, and the Saus-surea obvallata (DC.) Edgew of resource scarcity is maximized the use;
2, on drying means, while extract drying, add adjuvant, the adhesive effect of extract after adjuvant mixes with extract, can be reduced, and increase volume and make moisture Quick diffusing, make extract thoroughly dry, shorten drying time, the extract obtained the not easily moisture absorption, easily preserves.
Below that prior art extracts Saus-surea obvallata (DC.) Edgew and the inventive method to the contrast test of the effective ingredient yield of Saus-surea obvallata (DC.) Edgew lixiviate:
Method:
Prior art is extracted: the Saus-surea obvallata (DC.) Edgew after drying and crushing 500 grams is added the alcoholic solution 5000 milliliters of 50%, heating extraction 2-3 hour, extracts 3 times continuously, and last merge extractive liquid, is concentrated obtains extractum, spraying dry.Test three times
The inventive method is extracted: the Saus-surea obvallata (DC.) Edgew 500 grams after drying being shredded, put into steam explosion tank, under pressure 2MPa, after 5 minutes persistent period, release under being decompressed to normal pressure immediately, then use each 5000 milliliters of the alcoholic solution of 40%, 50%, 60% respectively, heating extraction 2-3 hour, continuous extraction 3 times, last merge extractive liquid, concentrates, and the adjuvant adding concentrated rear extracting solution weight 50% is dry.Test three times.
Result of the test is as follows:
Prior art extracts yield
The inventive method extracts yield
Conclusion: extract Saus-surea obvallata (DC.) Edgew by the inventive method, extracts yield far away higher than the extract yield 1-20% of prior art.
Detailed description of the invention:
Embodiment one:
The present embodiment improves the method for Saus-surea obvallata (DC.) Edgew yield, comprises the following steps:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping, length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.8MPa, steam explosion is after 6 minutes, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the water heating lixiviate Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 8 times amount, continuous 3 times, each extraction 2 hours, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.07MPa at temperature 55 DEG C, to concentrate extract to density be the extractum of 1.01, the rear 70 DEG C of dryings of beta-schardinger dextrin-mixing 12 hours adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Embodiment two:
The present embodiment improves the method for Saus-surea obvallata (DC.) Edgew yield, comprises the following steps:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping, length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 2MPa, steam explosion is after 4 minutes, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the ethanol heating lixiviate Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 12 times amount, continuous 2 times, each extraction 3 hours, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.06MPa at temperature 65 DEG C, to concentrate extract to density be the extractum of 1.1, the rear 50 DEG C of dryings of microcrystalline Cellulose mixing 48 hours adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Embodiment three:
The present embodiment improves the method for Saus-surea obvallata (DC.) Edgew yield, comprises the following steps:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping, length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.9MPa, steam explosion is after 5 minutes, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the petroleum ether heating lixiviate Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 10 times amount, continuous 3 times, each extraction 2 hours, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.06MPa under temperature 60 C, to concentrate extract to density be the extractum of 1.05, the rear 60 DEG C of dryings of starch mixing 30 hours adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Embodiment four:
The present embodiment Saus-surea obvallata (DC.) Edgew extract, comprises the following steps obtained:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping, length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.8MPa, steam explosion is after 6 minutes, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the water heating lixiviate Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 8 times amount, continuous 3 times, each extraction 2 hours, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.07MPa at temperature 55 DEG C, to concentrate extract to density be the extractum of 1.01, the rear 70 DEG C of dryings of beta-schardinger dextrin-mixing 12 hours adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Embodiment five:
The present embodiment Saus-surea obvallata (DC.) Edgew extract, comprises the following steps obtained:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping, length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 2MPa, steam explosion is after 4 minutes, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the ethanol heating lixiviate Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 12 times amount, continuous 2 times, each extraction 3 hours, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.06MPa at temperature 65 DEG C, to concentrate extract to density be the extractum of 1.1, the rear 50 DEG C of dryings of microcrystalline Cellulose mixing 48 hours adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Embodiment six:
The present embodiment Saus-surea obvallata (DC.) Edgew extract, comprises the following steps obtained:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping, length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.9MPa, steam explosion is after 5 minutes, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the petroleum ether heating lixiviate Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 10 times amount, continuous 3 times, each extraction 2 hours, and merge extractive liquid, obtains extract;
4) concentrate drying extract: being decompressed to 0.06MPa under temperature 60 C, to concentrate extract to density be the extractum of 1.05, the rear 60 DEG C of dryings of starch mixing 30 hours adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract.
Embodiment seven:
Above-mentioned Saus-surea obvallata (DC.) Edgew extract can treat application in disorder agent preparing Saus-surea obvallata (DC.) Edgew.Making an addition to Saus-surea obvallata (DC.) Edgew by the weight ratio of described Saus-surea obvallata (DC.) Edgew extract 20%-50% can in sanatory pharmaceutical preparation.
Claims (3)
1. improve a method for Saus-surea obvallata (DC.) Edgew yield, it is characterized in that comprising the following steps:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.8-2MPa after steam explosion 4-6 minute, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the extraction solvent lixiviate 2-3 time Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 8-12 times amount, each extraction 2-3 hour, and merge extractive liquid, obtains extract; Extraction solvent is water, alcohol, a kind of solvent in petroleum ether or the combination of two kinds of solvents;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa at temperature 55-65 DEG C, to concentrate extract to density be the extractum of 1.01-1.1, then 50-70 DEG C of dry 12-48 hour after the adjuvant mixing adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract; Adjuvant is one or more mixing of beta-schardinger dextrin-, microcrystalline Cellulose, starch.
2. a Saus-surea obvallata (DC.) Edgew extract, is characterized in that comprising the following steps obtained:
1) pretreatment: get Saus-surea obvallata (DC.) Edgew air-dry, chopping;
2) Steam explosion treatment: the Saus-surea obvallata (DC.) Edgew of chopping is put into steam explosion tank, under pressure 1.8-2MPa after steam explosion 4-6 minute, releases under being decompressed to normal pressure immediately;
3) reflux lixiviate: the extraction solvent lixiviate 2-3 time Saus-surea obvallata (DC.) Edgew after steam explosion being added volume ratio 8-12 times amount, each extraction 2-3 hour, and merge extractive liquid, obtains extract; Extraction solvent is water, alcohol, a kind of solvent in petroleum ether or the combination of two kinds of solvents;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa at temperature 55-65 DEG C, to concentrate extract to density be the extractum of 1.01-1.1, then 50-70 DEG C of dry 12-48 hour after the adjuvant mixing adding extractum weight 50%, obtain Saus-surea obvallata (DC.) Edgew extract; Adjuvant is one or more mixing of beta-schardinger dextrin-, microcrystalline Cellulose, starch.
3. Saus-surea obvallata (DC.) Edgew extract as claimed in claim 2 is preparing the application in medicine, it is characterized in that getting Saus-surea obvallata (DC.) Edgew extract makes an addition in the pharmaceutical preparation of menstruction regulating and pain relieving, anti-inflammation, treatment rheumatism with the weight ratio of 20%-50%.
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| CN106236809A (en) * | 2016-08-30 | 2016-12-21 | 青海民族大学 | Saus-surea obvallata (DC.) Edgew effective site and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102351826A (en) * | 2011-09-26 | 2012-02-15 | 重庆大学 | Extraction method of ginkgo leaf flavonoids based on steam explosion |
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| CN102351826A (en) * | 2011-09-26 | 2012-02-15 | 重庆大学 | Extraction method of ginkgo leaf flavonoids based on steam explosion |
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| 苞叶雪莲水提物对辐射损伤小鼠防护作用的研究;郭娜;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20111015;6-9页 * |
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