CN103735682B - A kind of medicine that is used for the treatment of allergic dermatitis and preparation method thereof - Google Patents
A kind of medicine that is used for the treatment of allergic dermatitis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to field of medicaments, relate in particular to a kind of medicine that is used for the treatment of allergic dermatitis and preparation method thereof. Ingredients by following parts by weight: 3 parts of dittany barks; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; 5 parts, Radix Glycyrrhizae; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; 3 parts of frutus cnidiis; 2 parts of the roots of large-flowered skullcap; Medicine as above is pulverized as powdery according to following any one mode processing: A., added vaseline or lanolin to be made as paste; B. above medicine pulverize adds water after 100 parts after 60 degrees Celsius of water temperatures make medicine concentrated after lower 2 hours and smears liquid as liquid; The above medicine of C filters after within lower 1 hour, adding alcohol precipitation by 100 degrees Celsius of the water temperatures of adding water after 100 parts, heating volatilization alcohol, and remaining liquid medicine is made emulsifiable paste by emulsion process. Adopt as above the present invention of technical scheme, have following beneficial effect with respect to prior art: this product pure Chinese medicinal preparation, not containing any hormone, treatment allergic dermatitis has good effect.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicine that is used for the treatment of allergic dermatitis and preparation method thereof.
Background technology
Allergic dermatitis is the skin disease being caused by anaphylactogen, mainly refers to that human body touches some anaphylactogen and causes skinSkin redness, itch, the skin disorder such as wheal, decortication. Concrete anaphylactogen can be divided into contact allergy former, suck anaphylactogen, foodEnter anaphylactogen and be injected into anaphylactogen four classes. Every class anaphylactogen can cause corresponding allergic reaction, and main performance is manyPlant various dermatitis, eczema, nettle rash.
The medicine of present allergic dermatitis has side effect more, and is mainly Western medicine, and motherland's medical science traditional Chinese medical science also can in factTreat this disease and do not introduce hormone.
Summary of the invention
The object of invention: for the medicine and the preparation side thereof that are used for the treatment of allergic dermatitis that a kind of result for the treatment of is good is providedMethod.
In order to reach as above object, the present invention takes following technical scheme:
Scheme 1:
A medicine that is used for the treatment of allergic dermatitis, is characterized in that, the ingredients by following parts by weight: dittany3 parts of skins; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; 5 parts, Radix Glycyrrhizae; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; Cnidium monnieri3 parts of sons; 2 parts of the roots of large-flowered skullcap.
Scheme 2:
A preparation method who is used for the treatment of the medicine of allergic dermatitis, is characterized in that,
Ingredients by following parts by weight: 3 parts of dittany barks; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; Sweet5 parts of grass; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; 3 parts of frutus cnidiis; 2 parts of the roots of large-flowered skullcap;
Medicine as above is pulverized as powdery according to following any one mode processing: A., added vaseline or sheepHair fat is made as paste; B. add water after 100 parts 60 degrees Celsius of water temperatures of above medicine pulverize make medicine concentrated after lower 2 hoursSmear liquid as liquid afterwards; The above medicine of C adds mistake after alcohol precipitation for lower 1 hour by 100 degrees Celsius of the water temperatures of adding water after 100 partsFilter, heating volatilization alcohol, remaining liquid medicine, through by after 150 mesh sieve, is used oil-in-water type matrix (hydrophily creme) systemBecome emulsifiable paste, proportioning is, Chinese medicine composition: 50g, and stearic acid: 150g, lanolin: 20g, liquid paraffin: 220g, triethanolamine:40g, glycerine: 50g, distilled water: 475g.
Adopt as above the present invention of technical scheme, have following beneficial effect with respect to prior art: the pure Chinese medicine system of this productAgent, not containing any hormone, treatment allergic dermatitis has good effect.
Detailed description of the invention
Below in conjunction with embodiments of the invention are described, embodiment is not construed as limiting the invention:
Embodiment 1:
Ingredients by following parts by weight: 3 parts of dittany barks; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; Sweet5 parts of grass; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; 3 parts of frutus cnidiis; 2 parts of the roots of large-flowered skullcap;
Medicine as above is processed in the following manner: A. pulverizes as powdery, added vaseline or lanolin and makeFor paste.
Using method: spread upon affected part, external application three times on the one.
Embodiment 2:
A preparation method who is used for the treatment of the medicine of allergic dermatitis, is characterized in that,
Ingredients by following parts by weight: 3 parts of dittany barks; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; Sweet5 parts of grass; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; 3 parts of frutus cnidiis; 2 parts of the roots of large-flowered skullcap;
Medicine as above is processed in the following manner: the above medicine pulverize of the B. water temperature 60 after 100 parts that adds waterAfter degree Celsius making medicine concentrated after lower 2 hours, smear liquid as liquid.
Using method: shake up and spread upon affected part, external application three times on the one.
Embodiment 3:
A preparation method who is used for the treatment of the medicine of allergic dermatitis, is characterized in that,
Ingredients by following parts by weight: 3 parts of dittany barks; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; Sweet5 parts of grass; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; 3 parts of frutus cnidiis; 2 parts of the roots of large-flowered skullcap;
Medicine as above is processed in the following manner: the above medicine of C is by adding water after 100 parts 100 degrees Celsius of water temperaturesAfter within lower 1 hour, adding alcohol precipitation, filter, heating volatilization alcohol, remaining liquid medicine is made emulsifiable paste by emulsion process.
Using method: spread upon affected part, external application three times on the one.
Above medicine all has anti-allergic effects to also have hormone-like effect, and minority is improved immune surface anesthetic effect.
Dark plum: nature and flavor: taste acid, puckery, property are flat, return liver, spleen, lung, large intestine channel, has and astringes the lung, puckery intestines, promotes the production of body fluid, pacifies fennel, hemostasisEffect, modern medicine study, contains the acid of Chinese holly wood-rimmed, malic acid, butanedioic acid, semen armeniacae amarae infantile malnutrition due to digestive disturbances or intestinalparasites etc.
Pharmacological action:
1, there is antihistamine: this will have antihistamine effect to guinea-pig isolated trachea, it works in fast, strong and lasting 5 minutesAnti-intensity exceedes 100%
2, desensitization: having desensitization, may be non-specifically to stimulate mouse produce in more free antibodies and invadeDue to anaphylactogen in body.
Other pharmacology the unknowns of important combination.
Cicada slough: taste is sweet cold in nature, returns lung, Liver Channel, has dispelling wind and heat from the body, and promoting eruption is antipruritic, depraved customs spasmolysis, removing nebula for improving eyesight effect.
Main component: chitin, the water extracts such as red butterfly cry of certain animals, keratin, amino acid are aobvious acids reaction still.
Pharmacology: calm anticonvulsion, antipyretic, antiviral, anti-allergic effects
Fourstamen Stephania Root (Stephania tetrandra): bitter, pungent, cold in nature, return lung, spleen, urinary bladder channel, contain multiple alkaloid, total amount approximately 1.5%～2.3%, mainly contain hanfangchin A 1%, hanfangchin B approximately 0.5%, hanfangchin C, cissamine and water-soluble alkaloidβ 6. The quaternary ammonium salt of being prepared by Fourstamen Stephania Root alkaloid have iodate dimethyl hanfangchin A (tetrandrine dimethiodide), bromine first element, Han Songmin andStephania tetrandra alkaloid β 5, still containing glycosides displayed, phenols, organic acid, volatilization wet goods, therefore have antipyretic, analgesia, anti-inflammatory, antiallergy, fallPress, expand hat, anti-miocardial infarction, arrhythmia, the effectiveness such as antibacterial, anticancer.
The effects such as central nervous system
Hanfangchin A in this medicine has the anti-allergic effects of steel vanadium, and test shows to suppress models of passive skin irritability of ratsReaction is shunk with the anaphylaxis of sensitized guinea pig Ileum From A White. Can resist the effect of Anaphylactic mediator, as inhibition histamine, acetylcholine drawThe Experimental Asthma In Guinea-pigs rising and the contraction of isolated guinea pig ileum and the rat skin vasopermeability that serotonin causes increase. Can alsoSuppress the release of Anaphylactic mediator, the Anaphylactic mediator that sensitized guinea pig lung causes by antigen as suppressed or anaphylaxis slow reacting substance (SRS)Release and dextran bring out the release of rat peritoneal mast cells. Think that this product is not only the anticaking agent of Anaphylactic mediator, alsoBe the sustained-release agent of Anaphylactic mediator, first element also has the effect of antiallergy shock.
Earthworm: taste is salty, cold in nature, returns liver, spleen, urinary bladder channel. Main component 6-hydroxyxanthine, amino acids, arachidonicAcid, butanedioic acid, the derivative element of nucleic acid, the plain lumbrofebrin of earthworm etc., LUMBRICUS arsenic content reaches 200ppm, after washing, can reduce content1/2-2/3, reaches safe handling scope.
It has calmness, anticonvulsion, antipyretic, hypotensive, the effect such as relieving asthma, and LUMBRICUS 90% alcohol-extracted extract can obviously increase greatlyWhite mouse has the bronchial effect of diastole, the bronchoconstriction that earthworm medicinal extract can cause antihistaminicum and pilocarpinum, anti-groupKnit amine and experiment showed, that butanedioic acid is one of earthworm active ingredient of relievining asthma. Earthworm water decoction and carrying from earthworm water soluble ingredientThe several amino acids going out all has certain antiasthmatic effect, the hypoxanthine containing in earthworm to guinea pig tissues amine spraying experimental asthmaThere is antihistaminic effect.
Rhizoma atractylodis: taste is pungent, bitter, warm in nature, your spleen, stomach warp, have dry temperature invigorating spleen and dispelling wind-evil dehumidifying, and modern study has the about 5%-of volatile oil9%, main containing atractylol, atractylone, sagittol in oil, hinesol etc., still containing carrotene, vitamin A, vitamin B1Deng. The effects such as this product has antiallergy, antirheumatic, volatile oil affects nervous centralis, is paralysis effect, has the effect of pain relieving, calmness.
The Radix Astragali: taste is sweet, cold nature, returns spleen, lung channel, supplements and rises sun, invigorating qi for consolidating superficies, promoting pus discharge and tissue regeneration, inducing diuresis for removing edema.
Main component: dihydroxy-5,6-dimethyl isoflavones, saponin, choline, betaine, amino acid, cumarin, HuangAstragalus polysaccharides, Glucoamino acid, micro-folic acid, linoleic acid, leukotrienes, also have alkaloid, nicotinic acid, niacinamide, shallow lake phenolase, traceElemental selenium etc.
Pharmacological action: have adjusting immunologic function, strengthen metabolism, improve vitality and the resistance of cell, the Radix Astragali is sexual to swashThe effect of element sample, can promote men and women's sexual gland technical ability, can be promoting blood circulation and removing blood stasis, promote skin blood circulation, and improve nutrition condition, and can reduce hairThe permeability of thin blood vessel circulation. Astragalus saponin 1 has antiinflammatory action, energy stabilizing cell membrane, and antihistamine and reduction vasopermeability,Its similar cortex hormone of aadrenaline sample of anti-allergic effects effect, the Radix Astragali can strengthen the anti-ability that stress be plain of big white mouse, worksRealize by strengthening adrenal cortex function.
Radix Glycyrrhizae: taste is sweet, property is flat, the thoughts of returning home, lung, spleen, stomach warp, containing glycyrrhizin, the ammonium of glycyrrhizic acid, potassium, calcium, salt are Radix GlycyrrhizaesSweet ingredient, sweet taste is sucrose 50 times, glycyrrhizin is a kind of triterpenoid saponin, the aqueous solution has foaming characteristic, after glycyrrhizic acid hydrolysisThe enoxolone and the dimolecular glucuronic acid that produce a part also have multiple flavone compound as glycyrrhizin, different Radix GlycyrrhizaeElement, hay glucoside etc.
Pharmacology: the effect of cortex hormone of aadrenaline sample, because of the chemical constitution of enoxolone similar to cortin sample, therefore can be straightThe effect of glucocorticoid sample is waved in sending and receiving, and anti-inflammatory, the reflection of resistance state, antiallergy are mainly to have affected biological oxidation process in cell,Reduced cell to the reaction stimulating, can suppress capillary permeability, anti-allergic effects dosage great master effect is also large. Radix Glycyrrhizae30g has similar hormone-like effect above.
The root of large-flowered skullcap: bitter, cold in nature, return lung, courage, stomach, large intestine channel, there are heat-clearing and damp-drying drug, purging intense heat and detonicating, contain baicalein, HuangA kind of reed mentioned in ancient books glucoside, wogonin, benzoic acid, this medicine heating energy destroys the active ingredient of baicalinase with the protection root of large-flowered skullcap.
There are relexation in astragalin, astragalin unit to guinea-pig isolated trachea, can alleviate the contraction of bronchus anaphylaxis and entiretyAnimal allergic asthma, astragalin unit can also reduce the permeability of capillary, to cause passive systemic anaphylaxis, quilt because of histamineMoving allergic and dermoreaction all has inhibitory action, and this pathology state reagentia may be to have injured mast cell enzyme to activate systemSystem, suppresses due to the release of anaphylaxis medium.
Dittany bark: bitter, cold in nature, return spleen, stomach warp, there is clearing heat and detoxicating, the dehumidifying wind action of dispelling
Containing alkaloids such as dictaminine, skimmianine, still there are Limettin, obakunone, saponin sitosterol, volatilization wet goods composition,Volatile oil is light green color, has the strong sheep gas of having a strong smell. Dittany bark water logging agent has inhibitory action to fungi, has anti-allergic effects, thereforeThere are antiallergy, anti-infective, the purulence of dispelling, the effect such as antipruritic.
Kuh-seng: bitter, cold in nature, the thoughts of returning home, liver, stomach, large intestine, urinary bladder channel, heat-clearing, eliminating dampness, dispel the wind, desinsection, clear away heart-fire, multiple arteries and veinsDeng.
Pharmacological action: multiple alkaloid, as matrine, the matrine of growing flower, caulophylline, anagyrine, kuh-seng card product alkali,According to file report radix sophorae, containing Xanthohumol, different anhydroicartin, has antibacterial, antiinflammatory action.
Frutus cnidii: taste is pungent, bitter, warm in nature, warm stomach sun, loose cold dispeling the wind, external application removing dampness and destroying parasites
Containing multiple coumarin derivative as A Naibaizhinei junket, columbianetin, lupulin etc., also have volatile oil,,Left-handed firpene, isovaleric acid, borneol acetate etc., methoxyl group Europe mustard phenol, edultin, party regulation acid fat etc., this medicine modern study has classLike gonadotropic Effect, there is anti-allergy action, next has anti-trichomonal, antibacterial, the effect of local anaesthesia and hypnosis.
Below enclose operation report
2010.5-2012.5 eczema is being changed 100 routine clinical observations, and various outpatient service eczema is clinical by external application Chinese medicine pasteObserve, male 47 examples, female's 53 examples, age 18-68 year, the oral antithistamine of severe patient is added to external application Chinese medicine paste, slightly suffer fromPerson's external application Chinese medicine paste, 3 hours antipruritic onset times, cure time 5.78 days, recovery from illness 85 examples, effective 9 examples, 4 examples that take a turn for the better are invalid2 examples, total effective rate 98%.
More than show and described general principle of the present invention, principal character and advantage of the present invention. The technology of this areaPersonnel should understand the present invention and not be restricted to the described embodiments, and that in above-described embodiment and description, describes just illustrates thisBright principle, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, these variationsAll fall in claimed scope with improving.
Claims (2)
1. a medicine that is used for the treatment of allergic dermatitis, is characterized in that, the ingredients by following parts by weight: dittany bark3 parts; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; 5 parts, Radix Glycyrrhizae; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; Frutus cnidii 3Part; 2 parts of the roots of large-flowered skullcap.
2. a preparation method who is used for the treatment of the medicine of allergic dermatitis, is characterized in that,
Ingredients by following parts by weight: 3 parts of dittany barks; 5 parts of dark plums; 3 parts of cicada sloughs; 3 parts of kuh-sengs; 3 parts of earthworms; Radix Glycyrrhizae 5Part; 2 parts of Fourstamen Stephania Roots; 3 parts of rhizoma atractylodis; 5 parts of the Radixs Astragali; 3 parts of frutus cnidiis; 2 parts of the roots of large-flowered skullcap;
Medicine as above is pulverized as powdery according to following any one mode processing: A., added vaseline or lanolinBe made as paste; B. above medicine pulverize adds water after 100 parts after 60 degrees Celsius of water temperatures make medicine concentrated after lower 2 hours and doesFor liquid is smeared liquid; The above medicine of C filters after within lower 1 hour, adding alcohol precipitation by 100 degrees Celsius of the water temperatures of adding water after 100 parts,Heating volatilization alcohol, remaining liquid medicine is through by after 150 mesh sieve, makes emulsifiable paste by oil-in-water type matrix, and proportioning is, inDrug composition: 50g, stearic acid: 150g, lanolin: 20g, liquid paraffin: 220g, triethanolamine: 40g, glycerine: 50g, distillationWater: 475g.
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| CN115386643A (en) * | 2022-08-18 | 2022-11-25 | 宁波赛缪斯生物科技有限公司 | Method for customizing skin care product based on anti-inflammatory gene and skin care product |
| CN115887265A (en) * | 2022-11-03 | 2023-04-04 | 青蛙王子（福建）婴童护理用品有限公司 | JAK1 signal channel inhibitor and application thereof in anti-inflammatory and soothing cosmetics |
Citations (3)
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| CN1843435A (en) * | 2006-02-20 | 2006-10-11 | 重庆希尔安药业有限公司 | Itch-stopping cicada formulation and its preparation method |
| CN1977916A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin disease |
| CN102895558A (en) * | 2012-10-25 | 2013-01-30 | 辛晓林 | Chinese medicine for treating allergic dermatitis |
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843435A (en) * | 2006-02-20 | 2006-10-11 | 重庆希尔安药业有限公司 | Itch-stopping cicada formulation and its preparation method |
| CN1977916A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin disease |
| CN102895558A (en) * | 2012-10-25 | 2013-01-30 | 辛晓林 | Chinese medicine for treating allergic dermatitis |
Non-Patent Citations (3)
| Title |
|---|
| 中医药治疗遗传过敏性皮炎近况(综述);张晓红;<<北京中医药大学学报>>;20010731;第24卷(第4期);72-74 * |
| 中药冷喷治疗面部化妆品接触性皮炎;宁晓洪等;<<内蒙古民族大学学报>>;20080331;第14卷(第2期);120,137 * |
| 治疗接触性皮炎的中药筛选及其治疗机制探索;黄礴等;<<现代中西医结合杂志>>;20070131;第16卷(第1期);132-134 * |
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