CN103191166A - Method for increasing yield of saussurea obvallata, extract of saussurea obvallata and application of extract - Google Patents
Method for increasing yield of saussurea obvallata, extract of saussurea obvallata and application of extract Download PDFInfo
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- CN103191166A CN103191166A CN201310113712XA CN201310113712A CN103191166A CN 103191166 A CN103191166 A CN 103191166A CN 201310113712X A CN201310113712X A CN 201310113712XA CN 201310113712 A CN201310113712 A CN 201310113712A CN 103191166 A CN103191166 A CN 103191166A
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Abstract
The invention belongs to a traditional Chinese medicine active component part, an extraction method of the traditional Chinese medicine active component part and application of the traditional Chinese medicine active component part in pharmaceutical preparations which can treat diseases. The extraction method comprises the steps of pretreatment, steam explosion treatment, refluxing extraction, and concentration and drying of an extract for obtaining a saussurea obvallata extract. According to the invention, 20-50wt% of the saussurea obvallata extract is added to a saussurea obvallata pharmaceutical preparation which can treat diseases. The extraction method has the beneficial effects that a steam explosion technology is used so that active components in the saussurea obvallata are fully extracted, and the extract yield can reach 20-50 percent, thus utilizing the rare saussurea obvallata resources to the maximum; in a drying method, adjuvant materials are added when the extract is dried, and after the adjuvant materials and the extract are mixed, the bonding action of the extract can be reduced, and the volume of the extract is also increased so that water can be rapidly diffused, thus completely drying the extract and shortening the drying time, so that the obtained extract hardly absorbs moisture and can be preserved easily.
Description
Technical field
Pharmaceutically active ingredient position and extracting method in the invention belongs to, and should in the pharmaceutically active ingredient position application in can sanatory pharmaceutical preparation in this of pharmaceutically active ingredient position.
Background technology
At present, conventional method is adopted in the extraction of Saus-surea obvallata (DC.) Edgew, as: the Saus-surea obvallata (DC.) Edgew after the drying and crushing is added 50% alcoholic solution heating extraction several times, and last merge extractive liquid, concentrates and obtains extractum, and spray drying gets extract.Extract Saus-surea obvallata (DC.) Edgew in this way, its yield low (only 1-20%), waste is big, and the dry difficulty of extract is big, and the time is long, the cost height, the moisture absorption be cannot say for sure to deposit easily.
Summary of the invention
The problem to be solved in the present invention is exactly to provide a kind of method that improves the effective component extracts yield of Saus-surea obvallata (DC.) Edgew at above deficiency, and the Saus-surea obvallata (DC.) Edgew extract that in this way obtains, also have the application of this extract in Saus-surea obvallata (DC.) Edgew can sanatory pharmaceutical preparation.Its technical scheme is as follows:
Extracting method may further comprise the steps:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar, after steam explosion 4-6 under the pressure 1.8-2PM minute, be decompressed to immediately under the normal pressure and emit;
3) backflow lixiviate: the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added extraction solvent lixiviate 2-3 time that volume ratio 8-12 doubly measures, extracted 2-3 hour at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa under temperature 55-65 ℃, to concentrate extract to density be the extractum of 1.01-1.1, and the adjuvant that adds extractum weight 50% again mixed 50-70 ℃ of back dry 12-48 hour, got the Saus-surea obvallata (DC.) Edgew extract.
Described Saus-surea obvallata (DC.) Edgew extract may further comprise the steps and makes:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar, after steam explosion 4-6 under the pressure 1.8-2PM minute, be decompressed to immediately under the normal pressure and emit;
3) backflow lixiviate: the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added extraction solvent lixiviate 2-3 time that volume ratio 8-12 doubly measures, extracted 2-3 hour at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa under temperature 55-65 ℃, to concentrate extract to density be the extractum of 1.01-1.1, and the adjuvant that adds extractum weight 50% again mixed 50-70 ℃ of back dry 12-48 hour, got the Saus-surea obvallata (DC.) Edgew extract.
The present invention also provides above-mentioned Saus-surea obvallata (DC.) Edgew extract can treat application in the disease medicine at the preparation Saus-surea obvallata (DC.) Edgew.By the weight ratio of described Saus-surea obvallata (DC.) Edgew extract 20%-50% make an addition to Saus-surea obvallata (DC.) Edgew can sanatory pharmaceutical preparation in.
Because the Saus-surea obvallata (DC.) Edgew nature and flavor are sweet, bitter, warm, go into liver,spleen,kidney three warps, kidney invigorating and YANG supporting arranged, regulating menstruation, hemostasis, removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation to restore menstrual flow network, the effect of blood stasis dispelling.The extract of gained can be used for the kidney invigorating, menstruction regulating and pain relieving, and anti-inflammation is on treatment rheumatism, the disease such as restore menstrual flow and invigorate blood circulation.The Saus-surea obvallata (DC.) Edgew extract feeds intake by national standard prescription consumption, after carrying out single or being equipped with corresponding other medical material compound recipes and cooperating, be prepared into various preparations such as pill, tablet, granule, capsule, drop pill, syrup etc. and be used for above-mentioned treatment of conditions.
Compared with prior art, the beneficial effect that has of the present invention is:
1, adopt the steam explosion technology to impel that effective ingredient fully leaches in the Saus-surea obvallata (DC.) Edgew, the extract yield can reach 20-50%, is much higher than conventional extract yield 1-20%, and the Saus-surea obvallata (DC.) Edgew of resource scarcity is maximized the use;
2, on drying means, in the extract drying, add adjuvant, adjuvant and the adhesive effect that can reduce extract after extract mixes, and increase volume moisture is distributed fast, make extract thoroughly dry, shorten drying time, the extract that obtains is difficult for the moisture absorption, easily preserves.
Below be that prior art is extracted Saus-surea obvallata (DC.) Edgew and the inventive method to the contrast test of the effective ingredient yield of Saus-surea obvallata (DC.) Edgew lixiviate:
Method:
Prior art is extracted: Saus-surea obvallata (DC.) Edgew 500 grams after the drying and crushing are added 5000 milliliters of 50% alcoholic solution, and heating extraction 2-3 hour, extract continuously 3 times, last merge extractive liquid, concentrates and obtains extractum, spray drying.Test three times
The inventive method is extracted: with Saus-surea obvallata (DC.) Edgew 500 grams after the drying chopping, put into the steam explosion jar, under the pressure 2PM, after 5 minutes persistent period, be decompressed to immediately under the normal pressure and emit, use each 5000 milliliters of 40%, 50%, 60% alcoholic solution then respectively, heating extraction 2-3 hour, extract 3 times continuously, last merge extractive liquid, concentrates, and adds the adjuvant drying that concentrates back extracting solution weight 50%.Test three times.
Result of the test is as follows:
Prior art is extracted yield
The inventive method is extracted yield
Conclusion: extract Saus-surea obvallata (DC.) Edgew with the inventive method, extract the extract yield 1-20% that yield is higher than prior art far away.
The specific embodiment:
Embodiment one:
Present embodiment improves the method for Saus-surea obvallata (DC.) Edgew yield, may further comprise the steps:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping, and length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar,, be decompressed to immediately under the normal pressure and emit after 6 minutes at steam explosion under the pressure 1.8PM;
3) backflow lixiviate: the water that the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added 8 times of amounts of volume ratio heats lixiviate, and continuous 3 times, extracted 2 hours at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.07MPa under 55 ℃ of temperature, to concentrate extract to density be 1.01 extractum, and the beta-schardinger dextrin-that adds extractum weight 50% again mixed back 70 ℃ of dryings 12 hours, got the Saus-surea obvallata (DC.) Edgew extract.
Embodiment two:
Present embodiment improves the method for Saus-surea obvallata (DC.) Edgew yield, may further comprise the steps:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping, and length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar,, be decompressed to immediately under the normal pressure and emit after 4 minutes at steam explosion under the pressure 2PM;
3) backflow lixiviate: the ethanol that the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added 12 times of amounts of volume ratio heats lixiviate, and continuous 2 times, extracted 3 hours at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06MPa under 65 ℃ of temperature, to concentrate extract to density be 1.1 extractum, and the microcrystalline Cellulose that adds extractum weight 50% again mixed back 50 ℃ of dryings 48 hours, got the Saus-surea obvallata (DC.) Edgew extract.
Embodiment three:
Present embodiment improves the method for Saus-surea obvallata (DC.) Edgew yield, may further comprise the steps:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping, and length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar,, be decompressed to immediately under the normal pressure and emit after 5 minutes at steam explosion under the pressure 1.9PM;
3) backflow lixiviate: the petroleum ether that the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added 10 times of amounts of volume ratio heats lixiviate, and continuous 3 times, extracted 2 hours at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06MPa under 60 ℃ of temperature, to concentrate extract to density be 1.05 extractum, and the starch that adds extractum weight 50% again mixed back 60 ℃ of dryings 30 hours, got the Saus-surea obvallata (DC.) Edgew extract.
Embodiment four:
Present embodiment Saus-surea obvallata (DC.) Edgew extract may further comprise the steps and makes:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping, and length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar,, be decompressed to immediately under the normal pressure and emit after 6 minutes at steam explosion under the pressure 1.8PM;
3) backflow lixiviate: the water that the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added 8 times of amounts of volume ratio heats lixiviate, and continuous 3 times, extracted 2 hours at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.07MPa under 55 ℃ of temperature, to concentrate extract to density be 1.01 extractum, and the beta-schardinger dextrin-that adds extractum weight 50% again mixed back 70 ℃ of dryings 12 hours, got the Saus-surea obvallata (DC.) Edgew extract.
Embodiment five:
Present embodiment Saus-surea obvallata (DC.) Edgew extract may further comprise the steps and makes:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping, and length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar,, be decompressed to immediately under the normal pressure and emit after 4 minutes at steam explosion under the pressure 2PM;
3) backflow lixiviate: the ethanol that the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added 12 times of amounts of volume ratio heats lixiviate, and continuous 2 times, extracted 3 hours at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06MPa under 65 ℃ of temperature, to concentrate extract to density be 1.1 extractum, and the microcrystalline Cellulose that adds extractum weight 50% again mixed back 50 ℃ of dryings 48 hours, got the Saus-surea obvallata (DC.) Edgew extract.
Embodiment six:
Present embodiment Saus-surea obvallata (DC.) Edgew extract may further comprise the steps and makes:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping, and length is at 1-1.5 centimetre, and width is at 0.3-0.6 centimetre;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar,, be decompressed to immediately under the normal pressure and emit after 5 minutes at steam explosion under the pressure 1.9PM;
3) backflow lixiviate: the petroleum ether that the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added 10 times of amounts of volume ratio heats lixiviate, and continuous 3 times, extracted 2 hours at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06MPa under 60 ℃ of temperature, to concentrate extract to density be 1.05 extractum, and the starch that adds extractum weight 50% again mixed back 60 ℃ of dryings 30 hours, got the Saus-surea obvallata (DC.) Edgew extract.
Embodiment seven:
Above-mentioned Saus-surea obvallata (DC.) Edgew extract can be treated application in the disease medicine at the preparation Saus-surea obvallata (DC.) Edgew.By the weight ratio of described Saus-surea obvallata (DC.) Edgew extract 20%-50% make an addition to Saus-surea obvallata (DC.) Edgew can sanatory pharmaceutical preparation in.
Claims (5)
1. method that improves the Saus-surea obvallata (DC.) Edgew yield is characterized in that may further comprise the steps:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar, after steam explosion 4-6 under the pressure 1.8-2PM minute, be decompressed to immediately under the normal pressure and emit;
3) backflow lixiviate: the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added extraction solvent lixiviate 2-3 time that volume ratio 8-12 doubly measures, extracted 2-3 hour at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa under temperature 55-65 ℃, to concentrate extract to density be the extractum of 1.01-1.1, and the adjuvant that adds extractum weight 50% again mixed 50-70 ℃ of back dry 12-48 hour, got the Saus-surea obvallata (DC.) Edgew extract.
2. according to the method for the described raising Saus-surea obvallata (DC.) Edgew of claim 1 yield, it is characterized in that adjuvant is one or more mixing of beta-schardinger dextrin-, microcrystalline Cellulose, starch.
3. according to the method for the described raising Saus-surea obvallata (DC.) Edgew of claim 1 yield, it is characterized in that extraction solvent is water, alcohol, n-butyl alcohol, the combination of a kind of solvent of petroleum ether or two kinds of solvents.
4. Saus-surea obvallata (DC.) Edgew extract is characterized in that may further comprise the steps and makes:
1) pretreatment: it is air-dry to get Saus-surea obvallata (DC.) Edgew, chopping;
2) steam explosion is handled: the Saus-surea obvallata (DC.) Edgew of chopping is put into the steam explosion jar, after steam explosion 4-6 under the pressure 1.8-2PM minute, be decompressed to immediately under the normal pressure and emit;
3) backflow lixiviate: the Saus-surea obvallata (DC.) Edgew behind the steam explosion is added extraction solvent lixiviate 2-3 time that volume ratio 8-12 doubly measures, extracted 2-3 hour at every turn, merge extractive liquid, gets extract;
4) concentrate drying extract: being decompressed to 0.06-0.07MPa under temperature 55-65 ℃, to concentrate extract to density be the extractum of 1.01-1.1, and the adjuvant that adds extractum weight 50% again mixed 50-70 ℃ of back dry 12-48 hour, got the Saus-surea obvallata (DC.) Edgew extract.
5. according to the described Saus-surea obvallata (DC.) Edgew extract of claim 4, it is characterized in that the Saus-surea obvallata (DC.) Edgew extract can treat application in the disease medicine at the preparation Saus-surea obvallata (DC.) Edgew.
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| CN201310113712.XA CN103191166B (en) | 2013-03-25 | 2013-04-02 | Improve the method for Saus-surea obvallata (DC.) Edgew yield and the application of extract and this extract |
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| CN201310097407.6 | 2013-03-25 | ||
| CN2013100974076 | 2013-03-25 | ||
| CN201310097407 | 2013-03-25 | ||
| CN201310113712.XA CN103191166B (en) | 2013-03-25 | 2013-04-02 | Improve the method for Saus-surea obvallata (DC.) Edgew yield and the application of extract and this extract |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550275A (en) * | 2013-11-01 | 2014-02-05 | 王颖 | Method for extracting saussurea involucrate essences |
| CN106236809A (en) * | 2016-08-30 | 2016-12-21 | 青海民族大学 | Saus-surea obvallata (DC.) Edgew effective site and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102351826A (en) * | 2011-09-26 | 2012-02-15 | 重庆大学 | Extraction method of ginkgo leaf flavonoids based on steam explosion |
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2013
- 2013-04-02 CN CN201310113712.XA patent/CN103191166B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102351826A (en) * | 2011-09-26 | 2012-02-15 | 重庆大学 | Extraction method of ginkgo leaf flavonoids based on steam explosion |
Non-Patent Citations (1)
| Title |
|---|
| 郭娜: "苞叶雪莲水提物对辐射损伤小鼠防护作用的研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》, 15 October 2011 (2011-10-15) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550275A (en) * | 2013-11-01 | 2014-02-05 | 王颖 | Method for extracting saussurea involucrate essences |
| CN103550275B (en) * | 2013-11-01 | 2016-01-20 | 王颖 | A kind of extracting method of Herba Saussureae Involueratae essence substance |
| CN106236809A (en) * | 2016-08-30 | 2016-12-21 | 青海民族大学 | Saus-surea obvallata (DC.) Edgew effective site and its preparation method and application |
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