CN105395988A - Antitumor oral liquid and preparation method thereof - Google Patents

Antitumor oral liquid and preparation method thereof Download PDF

Info

Publication number
CN105395988A
CN105395988A CN201510885682.3A CN201510885682A CN105395988A CN 105395988 A CN105395988 A CN 105395988A CN 201510885682 A CN201510885682 A CN 201510885682A CN 105395988 A CN105395988 A CN 105395988A
Authority
CN
China
Prior art keywords
parts
oral liquid
preparation
herba
raw material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510885682.3A
Other languages
Chinese (zh)
Inventor
刘红梅
刘恺
李军
李晓幸
霍莉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hebei University
Original Assignee
Hebei University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hebei University filed Critical Hebei University
Priority to CN201510885682.3A priority Critical patent/CN105395988A/en
Publication of CN105395988A publication Critical patent/CN105395988A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Physiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses antitumor oral liquid and a preparation method thereof. The antitumor oral liquid is mainly prepared from the following raw materials in parts by weight: 50-200 parts of ixeris chinensis nakai, 8-12 parts of rhizoma smilacis glabrae, 2-5 parts of pseudobulbus cremastrae seu pleiones, 5-8 parts of semen oroxyli bark, 10-15 parts of honeysuckle, 10-15 parts of dandelion, 8-10 parts of houttuynia cordata,5-8 parts of rhodiola rosea, 2-4 parts of frankincense, 2-4 parts of myrrh, 2-4 parts of fructus leonuri, 8-12 parts of rhizoma drynariae, 2-4 parts of kelp, 2-4 parts of seaweed, 8-12 parts of concha arcae, 4-6 parts of fried semen lepidii, 18-22 parts of radix astragali fried with honey, 8-12 parts of radix pseudostellariae, 8-12 parts of white hyacinth bean, 8-12 parts of trogopterus dung, 1-3 parts of cordyceps sinensis and 5-8 parts of fructus psoraleae. The preparation method comprises the following steps: drying and grinding the raw materials, so that raw material powder is obtained; mixing and extracting the raw material powder with ethanol with volume being 10-40 times the total volume of the raw material powder and with concentration being 60-80%, so that an extracting solution is obtained; and concentrating the extracting solution, so that a thick paste is obtained, diluting the thick paste in 1-10 times of water, sub-packaging and sealing, so that the antitumor oral liquid is obtained.

Description

Antineoplastic oral liquid and preparation method thereof
Technical field
The present invention relates to tcm field, particularly relate to a kind of antineoplastic oral liquid and preparation method thereof.
Background technology
Tumor refers to that body is under the effect of the various tumorigenesis factor, the neoplasm that local organization hyperplasia is formed.According to neoplastic cell characteristics and the hazardness degree to body, again tumor is divided into benign tumor and the large class of malignant tumor two, and cancer is the general name of malignant tumor.
At present, as the Therapeutic Method of malignant tumor, generally take chemotherapy, actinotherapy and shell therapy, actinotherapy side effect is large, normal cell and cancerous cell are damaged simultaneously, chemotherapy generally adopts antibiotic, metabolism, hormone medicine etc., is also have very large side effect.Therefore, the antitumour treatments that safety is high, side effect is little is expected.
The traditional Chinese medical science is thought, tumor is all enraged because being worried, depressed stasis, strongly fragrant fire-transformation of a specified duration, and fire-toxin gathers, and expectorant coagulates dampness, causes Rong Wei not enough, and QI and blood condensation intercepts meridians, forms lump gradually.Chinese traditional treatment tumor is nursed one's health from entirety, and side effect is little, but the deficiencies such as in the method for existing treatment by Chinese herbs tumor, ubiquity takes effect slowly, DeGrain.
On the other hand, Herba Sonchi Oleracei is that a kind of Compositae Herba Lactucae versicoloris of medicine-food two-purpose belongs to herbaceos perennial, and extensive growth is in all parts of the country, and herb contains multiple nutritional components, and containing effectively to antineoplastic various plants albumen, huge potential value being had to the treatment of tumor.
Summary of the invention
The object of this invention is to provide a kind of antineoplastic oral liquid and preparation method thereof, can antitumor, and have no side effect.
Other objects with some for achieving the above object, the present invention adopts following technical scheme:
A kind of antineoplastic oral liquid, the raw material primarily of following weight portion is prepared from:
Herba Sonchi Oleracei 50-200, Rhizoma Smilacis Glabrae 8-12, Pseudobulbus Cremastrae Seu Pleiones 2-5, Cortex Oroxyli 5-8, Flos Lonicerae 10-15, Herba Taraxaci 10-15, Herba Houttuyniae 8-10, Radix Rhodiolae 5-8, Olibanum 2-4, Myrrha 2-4, Fructus Leonuri 2-4, Rhizoma Drynariae 8-12, Thallus Laminariae (Thallus Eckloniae) 2-4, Sargassum 2-4, Concha Arcae 8-12, Semen Lepidii (Semen Descurainiae) fry 4-6, Radix Astragali processed with honey 18-22, Radix Pseudostellariae 8-12, Semen Lablab Album 8-12, Oletum Trogopterori 8-12, Cordyceps 1-3 and Fructus Psoraleae 5-8.
Preferably, in described antineoplastic oral liquid, the raw material primarily of following weight portion is prepared from:
Herba Sonchi Oleracei 150, Rhizoma Smilacis Glabrae 10, Pseudobulbus Cremastrae Seu Pleiones 3, Cortex Oroxyli 6, Flos Lonicerae 12, Herba Taraxaci 12, Herba Houttuyniae 9, Radix Rhodiolae 6, Olibanum 3, Myrrha 3, Fructus Leonuri 3, Rhizoma Drynariae 10, Thallus Laminariae (Thallus Eckloniae) 3, Sargassum 3, Concha Arcae 10, Semen Lepidii (Semen Descurainiae) stir-fry 5, Radix Astragali processed with honey 20, Radix Pseudostellariae 10, Semen Lablab Album 10, Oletum Trogopterori 10, Cordyceps 2 and Fructus Psoraleae 6.
A preparation method for antineoplastic oral liquid, comprises the following steps:
Step one, raw material drying, pulverizing, obtain material powder;
Step 2, by the 60-80% ethanol hybrid extraction of material powder and 10-40 times of volume, be extracted liquid;
Step 3, extract are concentrated, obtain thick paste, and by thick paste thin up 1-10 doubly, sealed packaging, obtains described Herba Sonchi Oleracei oral liquid.
Preferably, in the preparation method of described antineoplastic oral liquid, in step 2, concrete extracting process is: the mixture of material powder and alcoholic solution is heated to slight boiling condition and keeps 1-10 minute, carry out ultrasonic vibration 20-40 minute after being cooled to room temperature and make cell breakage, dissolution of cellular content, centrifugalize obtains supernatant, obtains extract.
Preferably, in the preparation method of described antineoplastic oral liquid, adopt and revolve the method concentrated extract of steaming in step 3, revolving and steaming temperature is 50-70 DEG C, revolves to steam to evaporate completely to ethanol to obtain thick paste.
Preferably, in the preparation method of described antineoplastic oral liquid, by the water mixing standardize solution of thick paste with 5 times of volumes, and ultrasonic vibration 10-40 minute makes thick paste disperse, and obtains oral liquid.
Preferably, in the preparation method of described antineoplastic oral liquid, in step 3, in gained Herba Sonchi Oleracei oral liquid, add the borage honey of 1-8%.
Preferably, in the preparation method of described antineoplastic oral liquid, adopt fresh Herba Sonchi Oleracei to be raw material in step one, and adopt vacuum freeze-drying method to carry out drying to Herba Sonchi Oleracei, concrete grammar is:
First quick-freezing 30-90 minute, then evacuation under subzero 23-25 DEG C condition by Herba Sonchi Oleracei and borage, carry out 110-60 DEG C of gradient cooling lyophilization, vacuum is 30-40Pa, and first stage baking temperature is 100-110 DEG C, keeps 2-3 hour; Be cooled to 75-80 DEG C, keep 1-2 hour; Be cooled to 60-70 DEG C, keep 1-2 hour.
The present invention at least comprises following beneficial effect: first, the present invention is by adopting Herba Sonchi Oleracei to be primary raw material, utilize Herba Sonchi Oleracei can effectively to antineoplastic feature, in conjunction with theory of Chinese medical science, with other plurality of Chinese compatibilities, with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expectorant, hard masses softening and resolving, the body resistance strengthening and constitution consolidating are Therapeutic Principle, reach and effectively resist and treat the effect of tumor.
In addition, by the plurality of raw materials comprising Herba Sonchi Oleracei is carried out alcohol extraction, and carry out ultrasonic vibration after the extraction, make membranolysis, cellular content fully discharges, can ensure that the extracts active ingredients of Herba Sonchi Oleracei and other raw materials is more abundant, improve described Herba Sonchi Oleracei oral liquid to the therapeutic effect of tumor.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below the present invention is elaborated, can implement according to this after consulting this description to make those of ordinary skill in the art.
A kind of antineoplastic oral liquid, the raw material primarily of following weight portion is prepared from: Herba Sonchi Oleracei 50-200, Rhizoma Smilacis Glabrae 8-12, Pseudobulbus Cremastrae Seu Pleiones 2-5, Cortex Oroxyli 5-8, Flos Lonicerae 10-15, Herba Taraxaci 10-15, Herba Houttuyniae 8-10, Radix Rhodiolae 5-8, Olibanum 2-4, Myrrha 2-4, Fructus Leonuri 2-4, Rhizoma Drynariae 8-12, Thallus Laminariae (Thallus Eckloniae) 2-4, Sargassum 2-4, Concha Arcae 8-12, Semen Lepidii (Semen Descurainiae) fry 4-6, Radix Astragali processed with honey 18-22, Radix Pseudostellariae 8-12, Semen Lablab Album 8-12, Oletum Trogopterori 8-12, Cordyceps 1-3 and Fructus Psoraleae 5-8.
The present invention is by adopting Herba Sonchi Oleracei to be primary raw material, utilize Herba Sonchi Oleracei can effectively to antineoplastic feature, take Herba Sonchi Oleracei as primary raw material, in conjunction with theory of Chinese medical science, by Herba Sonchi Oleracei and other plurality of Chinese compatibilities, with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expectorant, hard masses softening and resolving, the body resistance strengthening and constitution consolidating are Therapeutic Principle, reach and effectively resist and treat the effect of tumor.
In raw material used, Rhizoma Smilacis Glabrae, dampness removing is dispelled heat, can enter network, searches to pick and damp and hot accumulates poison; Pseudobulbus Cremastrae Seu Pleiones, sweet in the mouth, micro-pungent, cool in nature, there is effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation; Cortex Oroxyli, micro-hardship, sweet, cool, clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating; Flos Lonicerae, heat-clearing and toxic substances removing, enhancing immunity, hepatoprotective, antitumor, antiinflammatory; Herba Taraxaci, heat-transformation poison, the swollen tuberculosis of the evil that disappears, loose stagnant gas; Herba Houttuyniae, heat-clearing and toxic substances removing, antibacterial, antitumor, raising immunity; Radix Rhodiolae, QI invigorating lung heat clearing, dissipating blood stasis for subsidence of swelling, antitumor; Olibanum Myrrha, promoting blood circulation to remove blood stasis, alleviating pain and detumescence; Fructus Leonuri, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing; Rhizoma Drynariae, invigorates blood circulation, the kidney invigorating; Thallus Laminariae (Thallus Eckloniae) Sargassum, nature and flavor are salty-cold, have hard masses softening and resolving, expectorant; Concha Arcae, expectorant blood stasis dispelling, hard masses softening and resolving; Semen Lepidii (Semen Descurainiae) is fried, inducing diuresis to remove edema; Radix Astragali processed with honey, enhancing immunity, correction gas; Radix Pseudostellariae, replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung; Semen Lablab Album, invigorating the spleen for eliminating dampness, inducing diuresis to remove edema; Five Ganodermas, invigorating primordial QI, antitumor; Cordyceps, enhancing immunity, nourishing lung and kidney, has obvious inhibitory action to tumor; Fructus Psoraleae, spleen reinforcing stomach invigorating, kidney-replenishing.
In described antineoplastic oral liquid, the raw material primarily of following weight portion is prepared from: Herba Sonchi Oleracei 150, Rhizoma Smilacis Glabrae 10, Pseudobulbus Cremastrae Seu Pleiones 3, Cortex Oroxyli 6, Flos Lonicerae 12, Herba Taraxaci 12, Herba Houttuyniae 9, Radix Rhodiolae 6, Olibanum 3, Myrrha 3, Fructus Leonuri 3, Rhizoma Drynariae 10, Thallus Laminariae (Thallus Eckloniae) 3, Sargassum 3, Concha Arcae 10, Semen Lepidii (Semen Descurainiae) stir-fry 5, Radix Astragali processed with honey 20, Radix Pseudostellariae 10, Semen Lablab Album 10, Oletum Trogopterori 10, Cordyceps 2 and Fructus Psoraleae 6.
A preparation method for antineoplastic oral liquid, comprises the following steps: step one, raw material drying, pulverizing, obtain material powder; Step 2, by the 60-80% ethanol hybrid extraction of material powder and 10-40 times of volume, be extracted liquid; Step 3, extract are concentrated, obtain thick paste, and by thick paste thin up 1-10 doubly, sealed packaging, obtains described Herba Sonchi Oleracei oral liquid.
In the preparation method of described antineoplastic oral liquid, in step 2, concrete extracting process is: the mixture of material powder and alcoholic solution is heated to slight boiling condition and keeps 1-10 minute, carry out ultrasonic vibration 20-40 minute after being cooled to room temperature and make cell breakage, dissolution of cellular content, centrifugalize obtains supernatant, obtains extract.
In the preparation method of described antineoplastic oral liquid, adopt and revolve the method concentrated extract of steaming in step 3, revolving and steaming temperature is 50-70 DEG C, revolves to steam to evaporate completely to ethanol to obtain thick paste.
In the preparation method of described antineoplastic oral liquid, by the water mixing standardize solution of thick paste with 5 times of volumes, and ultrasonic vibration 10-40 minute makes thick paste disperse, and obtains oral liquid.Test proves, during dilution 5 times of volumes, antitumous effect is best.
In the preparation method of described antineoplastic oral liquid, in step 3, in gained Herba Sonchi Oleracei oral liquid, add the borage honey of 1-8%.Borage honey can improve immunity, and has analgesia, antitumaous effect.
In the preparation method of described antineoplastic oral liquid, adopt fresh Herba Sonchi Oleracei to be raw material in step one, and adopt vacuum freeze-drying method to carry out drying to Herba Sonchi Oleracei, concrete grammar is:
First quick-freezing 30-90 minute, then evacuation under subzero 23-25 DEG C condition by Herba Sonchi Oleracei and borage, carry out 110-60 DEG C of gradient cooling lyophilization, vacuum is 30-40Pa, and first stage baking temperature is 100-110 DEG C, keeps 2-3 hour; Be cooled to 75-80 DEG C, keep 1-2 hour; Be cooled to 60-70 DEG C, keep 1-2 hour.
Embodiment 1
1, take Herba Sonchi Oleracei 160 grams, Rhizoma Smilacis Glabrae 8 grams, Pseudobulbus Cremastrae Seu Pleiones 2 grams, Cortex Oroxyli 5 grams, Flos Lonicerae 10 grams, Herba Taraxaci 10 grams, Herba Houttuyniae 8 grams, Radix Rhodiolae 5 grams, Olibanum 2 grams, Myrrha 2 grams, Fructus Leonuri 2 grams, Rhizoma Drynariae 8 grams, Thallus Laminariae (Thallus Eckloniae) 2 grams, Sargassum 2 grams, Concha Arcae 8 grams, Semen Lepidii (Semen Descurainiae) fries 4 grams, Radix Astragali processed with honey 18 grams, Radix Pseudostellariae 8 grams, Semen Lablab Album 8 grams, Oletum Trogopterori 8 grams, Cordyceps 1 gram and Fructus Psoraleae 5 grams, material powder 240 grams is obtained after drying and crushing, material powder is mixed with 5000mL70% alcoholic solution, and be heated to micro-boiling 3 minutes, raw cell is fully broken, thus make the abundant stripping of the effective ingredient in raw material.
2, after being cooled to room temperature, centrifugalize goes out supernatant, then ultrasound assisted extraction 30min, then supernatant is revolved steaming with Rotary Evaporators 70 DEG C time, is all evaporated away by ethanol, remain about 180mL thick paste;
3, mixed with 820 ml distilled waters by thick paste, ultrasonic vibration 20 minutes, mixes well, and obtains extracting solution 1000 milliliters.
Embodiment 2
1, take Herba Sonchi Oleracei 180 grams, Rhizoma Smilacis Glabrae 10 grams, Pseudobulbus Cremastrae Seu Pleiones 3 grams, Cortex Oroxyli 6 grams, Flos Lonicerae 12 grams, Herba Taraxaci 12 grams, Herba Houttuyniae 9 grams, Radix Rhodiolae 6 grams, Olibanum 3 grams, Myrrha 3 grams, Fructus Leonuri 3 grams, Rhizoma Drynariae 9 grams, Thallus Laminariae (Thallus Eckloniae) 3 grams, Sargassum 3 grams, Concha Arcae 9 grams, Semen Lepidii (Semen Descurainiae) fries 5 grams, Radix Astragali processed with honey 20 grams, Radix Pseudostellariae 10 grams, Semen Lablab Album 10 grams, Oletum Trogopterori 10 grams, Cordyceps 2 grams and Fructus Psoraleae 6 grams, material powder 280 grams is obtained after drying and crushing, material powder is mixed with 4000mL75% alcoholic solution, and be heated to micro-boiling 5 minutes, raw cell is fully broken, thus make the abundant stripping of the effective ingredient in raw material.
2, after being cooled to room temperature, centrifugalize goes out supernatant, then ultrasound assisted extraction 25min, then supernatant is revolved steaming with Rotary Evaporators 60 DEG C time, is all evaporated away by ethanol, remain about 200mL thick paste;
3, mixed with 500 ml distilled waters by thick paste, ultrasonic vibration 20 minutes, mixes well, and obtains extracting solution 700 milliliters, adds 20 grams of borage honey, mixes well.
The foregoing is only embodiment of the present invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or the conversion of equivalent flow process, or indirectly or be directly used in other correlative technology fields, include in scope of patent protection of the present invention.

Claims (8)

1. an antineoplastic oral liquid, is characterized in that, the raw material primarily of following weight portion is prepared from:
Herba Sonchi Oleracei 50-200, Rhizoma Smilacis Glabrae 8-12, Pseudobulbus Cremastrae Seu Pleiones 2-5, Cortex Oroxyli 5-8, Flos Lonicerae 10-15, Herba Taraxaci 10-15, Herba Houttuyniae 8-10, Radix Rhodiolae 5-8, Olibanum 2-4, Myrrha 2-4, Fructus Leonuri 2-4, Rhizoma Drynariae 8-12, Thallus Laminariae (Thallus Eckloniae) 2-4, Sargassum 2-4, Concha Arcae 8-12, Semen Lepidii (Semen Descurainiae) fry 4-6, Radix Astragali processed with honey 18-22, Radix Pseudostellariae 8-12, Semen Lablab Album 8-12, Oletum Trogopterori 8-12, Cordyceps 1-3 and Fructus Psoraleae 5-8.
2. antineoplastic oral liquid as claimed in claim 1, it is characterized in that, the raw material primarily of following weight portion is prepared from:
Herba Sonchi Oleracei 150, Rhizoma Smilacis Glabrae 10, Pseudobulbus Cremastrae Seu Pleiones 3, Cortex Oroxyli 6, Flos Lonicerae 12, Herba Taraxaci 12, Herba Houttuyniae 9, Radix Rhodiolae 6, Olibanum 3, Myrrha 3, Fructus Leonuri 3, Rhizoma Drynariae 10, Thallus Laminariae (Thallus Eckloniae) 3, Sargassum 3, Concha Arcae 10, Semen Lepidii (Semen Descurainiae) stir-fry 5, Radix Astragali processed with honey 20, Radix Pseudostellariae 10, Semen Lablab Album 10, Oletum Trogopterori 10, Cordyceps 2 and Fructus Psoraleae 6.
3. a preparation method for antineoplastic oral liquid as claimed in claim 1, is characterized in that, comprises the following steps:
Step one, raw material drying, pulverizing, obtain material powder;
Step 2, by the 60-80% ethanol hybrid extraction of material powder and 10-40 times of volume, be extracted liquid;
Step 3, extract are concentrated, obtain thick paste, and by thick paste thin up 1-10 doubly, sealed packaging, obtains described Herba Sonchi Oleracei oral liquid.
4. the preparation method of antineoplastic oral liquid as claimed in claim 3, it is characterized in that, in step 2, concrete extracting process is: the mixture of material powder and alcoholic solution is heated to slight boiling condition and keeps 1-10 minute, carry out ultrasonic vibration 20-40 minute after being cooled to room temperature and make cell breakage, dissolution of cellular content, centrifugalize obtains supernatant, obtains extract.
5. the preparation method of antineoplastic oral liquid as claimed in claim 3, is characterized in that, adopts the method concentrated extract revolving steaming in step 3, and revolving and steaming temperature is 50-70 DEG C, revolves to steam to evaporate completely to ethanol to obtain thick paste.
6. the preparation method of antineoplastic oral liquid as claimed in claim 5, it is characterized in that, by the water mixing standardize solution of thick paste with 5 times of volumes, and ultrasonic vibration 10-40 minute makes thick paste disperse, and obtains oral liquid.
7. the preparation method of antineoplastic oral liquid as claimed in claim 3, is characterized in that, in step 3, adds the borage honey of 1-8% in gained Herba Sonchi Oleracei oral liquid.
8. the preparation method of antineoplastic oral liquid as claimed in claim 3, it is characterized in that, adopt fresh Herba Sonchi Oleracei to be raw material in step one, and adopt vacuum freeze-drying method to carry out drying to Herba Sonchi Oleracei, concrete grammar is:
First quick-freezing 30-90 minute, then evacuation under subzero 23-25 DEG C condition by Herba Sonchi Oleracei and borage, carry out 110-60 DEG C of gradient cooling lyophilization, vacuum is 30-40Pa, and first stage baking temperature is 100-110 DEG C, keeps 2-3 hour; Be cooled to 75-80 DEG C, keep 1-2 hour; Be cooled to 60-70 DEG C, keep 1-2 hour.
CN201510885682.3A 2015-12-03 2015-12-03 Antitumor oral liquid and preparation method thereof Pending CN105395988A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510885682.3A CN105395988A (en) 2015-12-03 2015-12-03 Antitumor oral liquid and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510885682.3A CN105395988A (en) 2015-12-03 2015-12-03 Antitumor oral liquid and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105395988A true CN105395988A (en) 2016-03-16

Family

ID=55461975

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510885682.3A Pending CN105395988A (en) 2015-12-03 2015-12-03 Antitumor oral liquid and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105395988A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105853504A (en) * 2016-04-01 2016-08-17 叶善中 Anticancer drink
CN105878936A (en) * 2016-05-27 2016-08-24 廖鲜芳 Anti-tumor traditional Chinese medicine composition
CN105878935A (en) * 2016-05-27 2016-08-24 廖鲜芳 Anti-tumor traditional Chinese medicine instant tea and making method thereof
CN105920530A (en) * 2016-05-27 2016-09-07 廖鲜芳 Anti-tumour traditional Chinese medicinal pills and preparation method thereof
CN105999056A (en) * 2016-05-27 2016-10-12 廖鲜芳 Preparation method of antineoplastic oral liquid
CN105999055A (en) * 2016-05-27 2016-10-12 廖鲜芳 Antineoplastic medicinal liquor and preparation method thereof
CN106036385A (en) * 2016-05-27 2016-10-26 廖鲜芳 Anti-tumor instant powder and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
朱宏吉等: "《制药设备与工程设计》", 31 July 2004, 化学工业出版社 *
王沛: "《中医肿瘤手册》", 28 February 2006, 福建科学技术出版社 *
谭兴贵等: "《中国食物药用大典》", 31 July 2013, 西安交通大学出版社 *
黄亚东等: "《生物工程设备及操作技术》", 30 September 2014, 中国轻工业出版社 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105853504A (en) * 2016-04-01 2016-08-17 叶善中 Anticancer drink
CN105853504B (en) * 2016-04-01 2020-01-21 叶善中 Anti-tumor beverage
CN105878936A (en) * 2016-05-27 2016-08-24 廖鲜芳 Anti-tumor traditional Chinese medicine composition
CN105878935A (en) * 2016-05-27 2016-08-24 廖鲜芳 Anti-tumor traditional Chinese medicine instant tea and making method thereof
CN105920530A (en) * 2016-05-27 2016-09-07 廖鲜芳 Anti-tumour traditional Chinese medicinal pills and preparation method thereof
CN105999056A (en) * 2016-05-27 2016-10-12 廖鲜芳 Preparation method of antineoplastic oral liquid
CN105999055A (en) * 2016-05-27 2016-10-12 廖鲜芳 Antineoplastic medicinal liquor and preparation method thereof
CN106036385A (en) * 2016-05-27 2016-10-26 廖鲜芳 Anti-tumor instant powder and preparation method thereof

Similar Documents

Publication Publication Date Title
CN105395988A (en) Antitumor oral liquid and preparation method thereof
CN103463516B (en) Traditional Chinese medicine ointment for treating dermatophytoses and preparation method thereof
CN104840695A (en) Medicine combination for treating white scour of piglet and preparation method thereof
CN104189495A (en) Traditional Chinese medicine preparation for treating breast cancer and preparation method thereof
CN105560987A (en) Traditional Chinese medicine composition for treating chilblain and preparation method thereof
CN105396017A (en) Traditional Chinese medicine preparation used for treating fatty liver, and preparation method thereof
CN104288451A (en) Traditional Chinese medicine preparation for treating cellulitis
CN103816413A (en) Traditional Chinese medicinal preparation for treating postoperative pneumonia
CN109821002A (en) A kind of Chinese herbs paste suitable for cancer pain
CN102327440A (en) Chinese herbal medicine for treating deep multiple abscess
CN106334140A (en) Traditional Chinese medicine composition and preparation method thereof
CN104257804A (en) Yao medicine preparation for treating acquired immune deficiency syndrome and preparation method of Yao medicine preparation
CN104998019A (en) Traditional Chinese medicine composition for promoting blood circulation for removing blood stasis and reliving bleeding and pain
CN105012642A (en) Preparation method of traditional Chinese medicine composition capable of promoting blood circulation to remove blood stasis, and stopping bleeding and relieving pain
CN105412673A (en) Drug for treating Hashimoto disease and preparing method thereof
CN105535865A (en) Method for preparing granule medicine for treating hyperplasia of mammary glands
CN105012789A (en) Composition for treating cervical cancer and preparation method thereof
CN105999056A (en) Preparation method of antineoplastic oral liquid
CN103989875A (en) Traditional Chinese medicine for treating chronic pancreatitis and preparation method thereof
CN104491628A (en) Traditional Chinese preparation used for treating breast tuberculosis and preparation method
CN104888148A (en) Medicament for chronic hepatitis B
CN108186952A (en) It is a kind of to be used to prevent Chinese herbal lotion of rabbit eczema and preparation method thereof
CN104107253B (en) A kind of Chinese medicine treating pityriasis rubra pilaris
CN105878935A (en) Anti-tumor traditional Chinese medicine instant tea and making method thereof
CN103432279A (en) Method for preparing soaking agent for preventing and treating gout with decoction dregs and product

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160316

RJ01 Rejection of invention patent application after publication