CN102429183B - Fruit-vegetable composition with functions of enhancing immunity and relaxing bowels and preparation method thereof - Google Patents
Fruit-vegetable composition with functions of enhancing immunity and relaxing bowels and preparation method thereof Download PDFInfo
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- CN102429183B CN102429183B CN2011103578166A CN201110357816A CN102429183B CN 102429183 B CN102429183 B CN 102429183B CN 2011103578166 A CN2011103578166 A CN 2011103578166A CN 201110357816 A CN201110357816 A CN 201110357816A CN 102429183 B CN102429183 B CN 102429183B
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Abstract
The invention discloses a fruit-vegetable composition with functions of enhancing immunity and relaxing bowels, which comprises the following components in percentage by weight: 0.1 percent-40 percent of fructooligosaccharide, 0.1 percent-40 percent of psyllium husk, 0.1 percent-40 percent of tremella, 0.1 percent-40 percent of tremella, 0.1 percent-40 percent of carrot, 0.1 percent-40 percent of asparagus, 0.1 percent-40 percent of lentinus edodes, 0.1 percent-40 percent of spiral seaweed, 0.1 percent-40 percent of alfalfa, and 0 percent to 50 percent of auxiliary materials. The main materials adopted by the fruit-vegetable composition are natural, mostly are vegetal, and have high safety; and the functions are clear and complementary to each other, and the immune action of a body is enhanced on the basis of improving a bowel function.
Description
Technical field
The present invention relates to the fruits and vegetables field, more specifically to a kind of fruits and vegetables composition and method of making the same with enhance immunity power and bowel relaxing functions.
Background technology
The health of hypoimmunity is easy to infected or cancer stricken; It is exactly liable to illness that hypoimmunity the most directly shows; Generally have a delicate constitution, performance such as malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, sleep-disorder, sick, have an injection and take medicine the normal potluck that just gets married.Each sickly all will could recover for a long time, and usually outbreak repeatedly.If things go on like this can cause health and intelligence development bad; Also be prone to bring out major disease; When the immune function of human body imbalance; When perhaps immune system was unsound, following point will show effect repeatedly: show effect repeatedly repeatedly, asthma is shown effect repeatedly, bronchitis is shown effect repeatedly, pneumonia is shown effect repeatedly by outbreak, tonsillitis for flu, the outbreak repeatedly of suffering from diarrhoea ....The most effectively means that change hypoimmunity are exactly balanced nutritious and strengthen motion.Constipation is that defecation frequency obviously reduces, and per 2～3 days or longer time, irregular, excrement matter is stiff, normal pathological phenomenon with the difficult defecation sense.Constipation is one of impaired symptom of function of intestinal canal, is the most common clinical symptoms of a kind of digestive system.Prolonged constipation can cause sizable harm to body, can aggravate a large amount of propagation of harmful bacterium and the increase of toxic metabolite product in the enteron aisle, makes intestinal microecology environment disequilibrium, forms vicious circle.Discover the relation that having of constipation and colorectal cancer is direct or indirect, the state of an illness of cardiovascular patients such as coronary heart disease, angina pectoris, apoplexy can also brought out or increase the weight of to constipation, causes its sudden death.
Therefore,, lack the situation of plant nutrients such as dietary fiber, develop one type of additional plant edible fiber, and increase defecation frequency through additional FOS, dietary fiber to less edible fruits of modern and vegetables.Though the kind of listing is more at present, the mechanism of action is also had any different, and still can not satisfy all kinds of crowds' daily life needs.
Summary of the invention:
The objective of the invention is on the basis of trophism theory; Satisfy more people's demand and washability; Filter out the effectively fruits and vegetables combination of enhance immunity power and bowel relaxing functions; The science of carrying out compatibility is brought into play it and is acted synergistically each other, thereby obtains a kind of fruits and vegetables composition with enhance immunity power and bowel relaxing functions.
Another object of the present invention is to provide a kind of fruits and vegetables preparation of compositions method.
Fruits and vegetables composition of the present invention, count by weight percentage and comprise following component:
FOS 0.1%～40%, isapgol husk 0.1%～40%, white fungus 0.1%～40%, konjaku 0.1%～40%; Carrot 0.1%～40%, asparagus 0.1%～40%, mushroom 0.1%～40%; Spirulina 0.1%～40%, clover 0.1%～40%, auxiliary material 0%～50%.
Above-mentioned fruits and vegetables composition; Described auxiliary material is counted by weight percentage and is comprised Fruit powder 0.0%～50%, flavoring essence 0.0%～50%, sweetener 0.0%～50%, acid 0.0%～50%, filler 0.0%～50%, lubricant 0.0%～50%, anticorrisive agent 0.0%～50%, suspending agent 0.0%～50%, food coloring 0.0%～50%, diluent 0.0%～50%%, plasticizer 0.0%～50%, processes peroral dosage form.
Said Fruit powder is by one or more mixing that are selected from orange powder, lemon powder, cherry powder, apple powder and the coconut palm powder; Said flavoring essence is by one or more mixing that are selected from orange essence, lemon extract, cherry essence, flavoring apple essence and the cocoanut flavour; Said sweetener is by being selected from one or more mixing in sweet of Sucralose, AK sugar, Aspartame, mogroside and knob; Said acid is by one or more mixing that are selected from citric acid, malic acid, lactic acid and the citric acid; Described filler is by one or more mixing that are selected from fructose, sugar alcohol, sucrose, starch and the dextrin; Said lubricant is by one or more mixing that are selected from talcum powder, dolomol, silica and the stearic acid; Said anticorrisive agent is by one or more mixing that are selected from Sodium Benzoate, Potassium Benzoate, sorbic acid methyl esters, ethyl-para-hydroxybenzoate and the P-hydroxybenzoic acid phenyl ester; Said suspending agent is by one or more mixing that are selected from sodium carboxymethylcellulose, sodium alginate and the beeswax; Described food coloring is by one or more mixing that are selected from burnt sugar coloring, Gardenia Yellow, curcumin and the chlorophyll; Said diluent is by one or more mixing that are selected from vegetable oil, propane diols and the polyethylene glycol; Said plasticizer is by one or more mixing that are selected from glycerine, sodium carboxymethylcellulose, sorbierite and the oleamide sodium sulfonate.
Above-mentioned fruits and vegetables composition, said peroral dosage form comprises pulvis, granule, tablet, hard capsule, soft capsule and oral liquid.
Above-mentioned fruits and vegetables preparation of compositions method, choosing white fungus, konjaku, carrot, asparagus, mushroom, spirulina, clover can be poach, is condensed into medicinal extract, makes extract powder, mixes getting final product again with FOS, isapgol husk and each auxiliary material.
Above-mentioned fruits and vegetables preparation of compositions method also can directly be allocated with the extract of each component.
Above-mentioned fruits and vegetables composition can be processed various peroral dosage forms by acceptable composition on bromatology, like pulvis, granule, tablet, hard capsule, soft capsule, oral liquid.
Above-mentioned fruits and vegetables composition can acceptable auxiliary be processed various peroral dosage forms on bromatology, like pulvis, granule, tablet, hard capsule, soft capsule and oral liquid.
Advantage of the present invention is: primary raw material is drawn materials natural, and majority is vegetable raw material, and is safe; Definite functions and complementing each other is being improved on the basis of function of intestinal canal, regulates human body immune function.Total dietary fiber that wherein is rich in and FOS all have good defecating feces excretion.FOS can produce a large amount of immunity substances through the proliferation function to Bifidobacterium in addition, stimulates the intestine immunity cell, increases the antibody cell quantity, the activity of activating macrophage, thereby body immune system.Raw material white fungus powder, konjaku powder, carrot meal, asparagus powder, mushroom powder, spirulina, extractive of alfalfa also can be from enhancing body immunity in varying degrees;
FOS can promote beneficial bacterium breedings such as Bifidobacterium, lactobacillus, significantly suppresses the existence of harmful bacterium simultaneously, realizes human microorganism's bidirectional modulation.FOS has the effect of obvious raising antibody forming cell number, NK cytoactive and raise immunity; Plantain seed kind skin contains the polysaccharide that can't be digested and assimilated, can relax bowel through absorbing moisture, and its effect is similar to bulk cathartic, in intestines, is not absorbed, and makes that osmotic pressure raises in the intestines, and large quantity of moisture remaines in enteric cavity and arrives and rush down; Tremella polysaccharides is the main active ingredient of white fungus, and multiple structure is arranged, and the overwhelming majority is water-soluble, belongs to water-soluble dietary fiber.Tremella polysaccharides has effects such as increasing immunity of organisms, antitumor, antiulcer disease; Konjaku glucomannan and goods thereof have good effect to prevention and treatment constipation, can absorb moisture, and softening ight soil increases faecal volume and reduces pH value in the enteron aisle; Beta carotene in the carrot can both improve immune response, immunity in the ability enhancing body, protection intestinal microecology.Carrot is rich in dietary fiber simultaneously, and the humoral secretion of ability obvious stimulation, enhance gastrointestinal wriggling, promotion defecation are used to treat constipation; The rutin that contains in the asparagus and multiple steroid saponin material and various trace elements have the adjusting organism metabolism, the effect of enhancing body immunity; Lentinan ability activating macrophage strengthens the macrophage phagocytic effect, and increases the infiltration of neutrocyte to the tumour joint; Spirulina has obvious effects to regulating the human immunologic function.The physiologically active ingredient scalable function of human body of enriching in the spirulina promotes cell metabolism, improves autoimmunity, anti-ageing, anti-oxidant, radioresistance; Alfalfa saponin can reducing blood lipid, promote cholesterol to drain, alleviate artery sclerosis, reduce low-density lipoprotein content, improve serum high-density LP content, analgesia, anti-inflammatory and antitumaous effect, thereby it has immunoregulatory effect.
The effect of each raw material of the present invention is complemented each other, and makes this product have the good enhance immunity power and the health care of defaecation.
Description of drawings
Fig. 1 is the oral liquid preparation technology flow chart of fruits and vegetables composition according to the invention;
Fig. 2 is the granule preparation technology flow chart of fruits and vegetables composition according to the invention;
Fig. 3 is the hard capsule preparation technology flow chart of fruits and vegetables composition according to the invention;
Fig. 4 is the tablet producing technology flow chart of fruits and vegetables composition according to the invention;
Fig. 5 is the pulvis preparation technology flow chart of fruits and vegetables composition according to the invention;
Fig. 6 is the soft capsule preparation process chart of fruits and vegetables composition according to the invention.
The specific embodiment
Embodiment one: the preparation method of oral liquid of the present invention, and as shown in Figure 1.
Take by weighing each component according to following percentage by weight:
With all raw material medicine materical crude slice after the assay was approved; Clean, subsequent use, white fungus, konjaku, carrot, asparagus, mushroom, clover, spirulina are carried out extracting in water, concentrate; Filtration makes concentrate; Add isapgol husk, FOS, antierythrite, lemon extract, malic acid, Sodium Benzoate, vitamin C, Aspartame, the purified water pulverized and mix, go up the bottle placer can behind the instantaneous sterilizing, get final product after the sterilization.
Embodiment two: the preparation of the granule of fruits and vegetables composition according to the invention, and as shown in Figure 2.
Take by weighing each component according to following percentage by weight:
With all raw material medicine materical crude slice after the assay was approved; Subsequent use, white fungus, konjaku, carrot, asparagus, mushroom, clover, spirulina are carried out extracting in water, concentrate, filter; Make concentrate; Drying obtains extract powder, adds FOS, isapgol husk, dextrin, antierythrite, apple powder, Aspartame, apple powder after pulverizing deliver to grain mechanism grain after mixing, and gets final product behind the whole grain.
Embodiment three: the preparation of the hard capsule of fruits and vegetables composition according to the invention, and as shown in Figure 3.
Take by weighing each component according to following percentage by weight:
With all raw material medicine materical crude slice after the assay was approved, subsequent use, white fungus, konjaku, carrot, asparagus, mushroom, clover, spirulina are carried out extracting in water, concentrate, filter; Make concentrate, drying obtains extract powder, isapgol husk, dolomol after adding FOS, the pulverizing; Mix, granulate drying; Whole grain sieves, and can gets final product.
Embodiment four: the preparation of the tablet of fruits and vegetables composition according to the invention, and as shown in Figure 4.
Take by weighing each component according to following percentage by weight:
With all raw material medicine materical crude slice after the assay was approved, subsequent use, white fungus, konjaku, carrot, asparagus, mushroom, clover, spirulina are carried out extracting in water, concentrate; Filter, make concentrate, drying obtains extract powder; Adding FOS, isapgol husk, dextrin, isomalt, orange powder, cherry essence, mogroside, dolomol, silica mix, and last granulator is granulated, drying; Whole grain is gone up the tablet press machine compressing tablet then, gets final product.
Embodiment five: the preparation of the pulvis of fruits and vegetables composition according to the invention, and as shown in Figure 5.
Take by weighing each component according to following percentage by weight:
With all raw material medicine materical crude slice after the assay was approved; Subsequent use, white fungus, konjaku, carrot, asparagus, mushroom, clover, spirulina are carried out extracting in water, concentrate, filter; Make concentrate; Drying obtains extract powder, adds FOS, isapgol husk, malt extract, lemon extract, silica, Aspartame, gets final product after mixing.
Embodiment six: the preparation of soft capsule of fruits and vegetables composition according to the invention, and as shown in Figure 6.
Take by weighing each component according to following percentage by weight:
Glue: gelatin 46%, glycerine 16%,
Purified water 37%, burnt sugar coloring 0.8%
Ethyl-para-hydroxybenzoate 0.2%
With all raw material medicine materical crude slice after the assay was approved; Subsequent use, white fungus, konjaku, carrot, asparagus, mushroom, clover, spirulina are carried out extracting in water, concentrate, filter; Make concentrate; Add the dextrin spray-drying and obtain the cream powder, adding FOS, isapgol husk, the soybean oil that takes by weighing capacity, beeswax are processed suspended matter after mixing, with processing rubber behind gelatin, glycerine, water, burnt sugar coloring, the ethyl-para-hydroxybenzoate mixing; The can of content suspended matter is pressed into soft capsule, gets final product after washing ball, drying.
Get the pulvis in the embodiment of the invention five, according to " health food check with assessment technique standard " (2003 editions), health food security toxicological evaluation program and method of inspection standard: the second portion toxicology method of inspection (one, acute toxicity test; Two, Salmonella reversion test; Three, bone marrow cell micronucleus test; Five, mouse sperm deformity test; 12,30 days feeding trials), carry out the test of security toxicological evaluation:
Result of the test shows, the per os acute toxicity test: female, male mouse: MTD＞17.98g/kg.BW, and classification belongs to nontoxic level according to the acute toxicity median lethal dose; The test of micronuclei in mice, mouse mouse sperm deformity: Salmonella reversion test is all negative.Feeding trial was not all seen harmful effect to each item indexs such as routine blood test, blood biochemistry index, organ coefficient and body weight, weightening finish, food-intake, food utilizations in 30 days.Histopathology is observed, and liver,spleen,kidney, stomach, duodenum, testis, ovary are not all seen significant pathological change.
Get the pulvis in the embodiment of the invention five; According to " health food check with assessment technique standard " (2003 editions), health food security toxicological evaluation program and method of inspection standard: second portion function assessment evaluation test method (26, the bowel relaxing functions method of inspection), carry out animal functional evaluation test (bowel relaxing functions):
Result of the test shows, per os gives this product 7 days of mouse various dose continuously, and each dose groups is not seen diarrhea of mouse, irritates stomach and gives compound diphenoxylate and cause mouse constipation model.Compare with model control group; Low dose group mouse small intestine prepared Chinese ink advance distance; Small intestine prepared Chinese ink propelling rate; Arrange melena time, 6 hours row's melena grain number first, 6 hours row's melena weight is significant difference (P＜0.05), 6 hours row's melena grain numbers, 6 hours row's melena weight there was no significant differences (P＞0.05); High dose group mouse small intestine prepared Chinese ink advance distance, prepared Chinese ink propelling rate obviously increase (P＜0.01), and row's melena weight increased (P＜0.05) in 6 hours, and row's melena weight increased (P＜0.05) in 6 hours, and row's melena grain was counted there was no significant difference (P＞0.05) in 6 hours; Compare the high, medium and low three dose groups body weight of blank group there are no significant difference (P＞0.05) with model control group.According to the criterion in " health food function assessment assessment process and method of inspection standard ", think that this product has the function of defaecation.
Get the pulvis in the embodiment of the invention five; Estimate assessment process and method of inspection standard according to " health food check with assessment technique standard " (2003 editions), health food function assessment: second portion function assessment evaluation test method (26, the bowel relaxing functions method of inspection), carry out the bowel relaxing functions human feeding trial:
Result of the test shows; 120 examples are met receive the accurate trial volunteer of test-object to be divided into test-meal group and control group at random by constipation symptom (defecation frequency, defecation condition, ight soil proterties); Have 5 examples to break away from the test-meal group process of the test, the disengaging rate is 8.3%, and 55 examples are tested in complete participation; There are 5 examples to break away from the control group process of the test, disengaging rate 8.3%, 55 examples are tested in complete participation.The test-meal group take this product after 7 days the result show: after the test-meal group experimenter test-meal with test-meal before relatively, defecation frequency obviously increases, defecation condition and ight soil proterties are obviously improved (P＜0.01); Test-meal group and control group compare after the test-meal, and defecation frequency obviously increases, and defecation condition and ight soil proterties are obviously improved difference has conspicuousness (P＜0.01).This product of decidable has the effect of bowel relaxing functions.Before and after this product of test-meal, the equal no abnormality seen of each item safety indexs such as routine blood test, blood biochemistry changes.Do not observe nauseating, flatulence, diarrhoea, allergy and other bad reactions during the test-meal.
Get the pulvis in the embodiment of the invention five; According to " health food check with assessment technique standard " (2003 editions), health food security toxicological evaluation program and method of inspection standard: second portion function assessment evaluation test method (, the function of enhancing immunity method of inspection), carry out animal functional evaluation test (function of enhancing immunity):
Result of the test shows; Per os gives the perfect board fruits and vegetables powder 30 days of mouse various dose; Can improve HD50 value, the mouse antibodies cellulation number of mouse; Promptly increase the humoral immunity ability: can strengthen the delayed allergy of mouse, promptly increase cellular immune function: the clear ability in carbon corridor that can improve mouse monokaryon-macrophage; The mouse spleen lymphocyte conversion capability that body weight gain, internal organs/body weight ratio, the ConA of mouse induced, ability, the NK cytoactive that Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell do not have influence.Judge that thus perfect board fruits and vegetables powder has the function of enhancing immunity effect.
According to " health food check and assessment technique standard " (2003 editions) regulation, function of enhancing immunity only need be carried out animal functional evaluation test, need not carry out human feeding trial.
Claims (6)
1. fruits and vegetables composition with enhance immunity power and bowel relaxing functions, count by weight percentage and comprise following component:
FOS 0.1%～40%, isapgol husk 0.1%～40%, white fungus 0.1%～40%, konjaku 0.1%～40%, carrot 0.1%～40%, asparagus 0.1%～40%, mushroom 0.1%～40%, spirulina 0.1%～40%, clover 0.1%～40%, auxiliary material 0%～50%.
2. fruits and vegetables composition according to claim 1 is characterized in that: described auxiliary material comprises following component by weight percentage:
3. fruits and vegetables composition according to claim 2 is characterized in that: said Fruit powder is by one or more mixing that are selected from orange powder, lemon powder, cherry powder, apple powder and the coconut palm powder; Said flavoring essence is by one or more mixing that are selected from orange essence, lemon extract, cherry essence, flavoring apple essence and the cocoanut flavour; Said sweetener is by being selected from one or more mixing in sweet of Sucralose, AK sugar, Aspartame, mogroside and knob; Said acid is by one or more mixing that are selected from citric acid, malic acid, lactic acid and the citric acid; Described filler is by one or more mixing that are selected from fructose, sugar alcohol, sucrose, starch and the dextrin; Said lubricant is by one or more mixing that are selected from talcum powder, dolomol, the silica; Said anticorrisive agent is by one or more mixing that are selected from Sodium Benzoate, Potassium Benzoate, sorbic acid methyl esters, the ethyl-para-hydroxybenzoate; Said suspending agent is by one or more mixing that are selected from sodium carboxymethylcellulose, sodium alginate and the beeswax; Described food coloring is by one or more mixing that are selected from burnt sugar coloring, Gardenia Yellow, curcumin and the chlorophyll; Said diluent is by one or more mixing that are selected from vegetable oil, propane diols and the polyethylene glycol; Said plasticizer is by one or more mixing that are selected from glycerine, sodium carboxymethylcellulose, sorbierite and the oleamide sodium sulfonate.
4. fruits and vegetables composition according to claim 1 is characterized in that: described fruits and vegetables composition is prepared to peroral dosage form.
5. fruits and vegetables composition according to claim 4 is characterized in that: said peroral dosage form comprises pulvis, granule, tablet, hard capsule, soft capsule and oral liquid.
6. fruits and vegetables preparation of compositions method according to claim 1; It is characterized in that: choose white fungus, konjaku, carrot, asparagus, spirulina, mushroom and clover through poach; Be condensed into medicinal extract then, make extract powder, mix getting final product again with FOS, isapgol husk and auxiliary material.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102813117A (en) * | 2012-09-07 | 2012-12-12 | 廖衍庆 | Health-care food |
| CN103251824A (en) * | 2013-04-19 | 2013-08-21 | 重庆安碧捷科技股份有限公司 | Chinese medicine composition for treating constipation and application of Chinese medicine composition |
| CN103598589B (en) * | 2013-11-16 | 2015-04-15 | 成都创盛生物医学材料有限公司 | Composition with therapy or health care effect |
| CN104172304B (en) * | 2014-07-11 | 2016-11-02 | 河北鲜元堂生物科技有限公司 | A kind of lyophilizing Spiroalgae block and preparation method thereof |
| CN106605909A (en) * | 2016-08-01 | 2017-05-03 | 西安源森生物科技有限公司 | Composition capable of relaxing the bowels, expelling toxin and preventing constipation, as well as preparation method thereof |
| CN108066384A (en) * | 2016-11-08 | 2018-05-25 | 郑州桂仁医药科技有限公司 | A kind of Chinese medicine preparation with strengthen immunity and preparation method thereof |
| CN107348298A (en) * | 2017-07-31 | 2017-11-17 | 无锡布莱尼斯生物科技有限公司 | A kind of gamma aminobutyric acid prebiotics solid beverage and preparation method thereof |
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|---|---|---|---|---|
| CN1079880A (en) * | 1993-04-07 | 1993-12-29 | 沈玉水 | Natural health-care tea for prolonging life and preventing cancer |
| CN101313748A (en) * | 2007-05-31 | 2008-12-03 | 威海紫光科技园有限公司 | Fig soft capsule and production process |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079880A (en) * | 1993-04-07 | 1993-12-29 | 沈玉水 | Natural health-care tea for prolonging life and preventing cancer |
| CN101313748A (en) * | 2007-05-31 | 2008-12-03 | 威海紫光科技园有限公司 | Fig soft capsule and production process |
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Effective date of registration: 20170227 Address after: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee after: Perfect (China) Co., Ltd. Patentee after: Perfect (Guangdong) Commodity Co., Ltd. Address before: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee before: Perfect (China) Co., Ltd. |