CN107875255B - Composition for relaxing bowel and losing weight - Google Patents
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- CN107875255B CN107875255B CN201711165828.2A CN201711165828A CN107875255B CN 107875255 B CN107875255 B CN 107875255B CN 201711165828 A CN201711165828 A CN 201711165828A CN 107875255 B CN107875255 B CN 107875255B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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Abstract
The invention discloses a composition for relaxing bowel and losing weight, which comprises Plantago ovata seed husk, fructus cannabis and/or konjaku flour, sesame and/or semen cassiae, sweet almond and optional astragalus. The composition is prepared by scientifically mixing various medicinal and edible food materials safe to human bodies or medicinal materials capable of being used as health-care products based on the basic theory of traditional Chinese medicines. The health-care food is fragrant in taste and rich in nutrition, has the effects of relaxing bowel and losing weight, has obvious curative effects on chronic constipation and obesity, and is suitable for various people to take.
Description
Technical Field
The invention relates to a functional food or health-care product, in particular to a functional food or health-care product with functions of relaxing bowel and losing weight.
Background
Along with the prolonging of the service life of people, the change of dietary habits and the influence of social pressure factors, the incidence rate of constipation tends to increase, and according to incomplete statistics, the prevalence rate of constipation in the population is as high as 27%, and constipation is often expressed as: less defecation and less defecation times; difficult and laborious defecation; the defecation is not smooth; dry stool, hard stool and unclean defecation; constipation is accompanied by abdominal pain or abdominal discomfort; at present, a plurality of health care products for treating constipation have the defects of different degrees: if the body is damaged by the strong excretion, for example, the intestinal mucosa is damaged by anthraquinone drugs such as rhubarb, and the large intestine is blackened by enteroscopy. The medicament has large side effect, is easy to cause liver injury, is easy to form dependence and aggravate constipation after stopping the medicament, has higher price and the like.
Meanwhile, the incidence of obesity has increased year by year due to overnutrition, lack of exercise, irregular life, etc., and has become an epidemic disease that rapidly increases in the global scope. With the rapid development of economy and the rapid improvement of the living standard of people, the prevalence rate of overweight and obesity in China is increased by times, and particularly the rise of the juvenile population is more obvious. According to estimation, at least 2 to 3 hundred million overweight people and at least 3 to 4 million obese people currently own China.
Obesity is closely related to health, and the probability of various diseases of obese people is far higher than that of weight standard people. These diseases include, but are not limited to, hypertension, dyslipidemia, coronary heart disease, ischemic stroke, diabetes, breast cancer, rectal cancer, prostate cancer, sleep apnea syndrome, gout, edema of the lower extremities, pain in the joints of the waist and legs, osteoporosis, etc., which severely affect quality of life. The annoyance and threat of obesity to people are increasingly being valued. Weight loss fever also becomes a new wave around the world. The weight loss of the medicine or the health-care product is realized by reducing the absorption of the human body to fat, increasing metabolism and the like, is relatively easy, but has serious interference to the normal function of the human body, has certain side effect, and still lacks safe and effective means for treating the obesity.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a safe and reliable composition which has no side effect and is used for relaxing bowel and losing weight.
The technical scheme adopted by the invention is as follows:
a composition for relaxing bowel and losing weight comprises the following effective raw materials in parts by weight:
30-70 parts of plantain seed husk, 10-40 parts of fructus cannabis and/or konjac flour, 10-30 parts of sesame and/or semen cassiae and 10-30 parts of sweet almond; or
30-60 parts of plantain seed husk, 10-40 parts of fructus cannabis and/or konjac flour, 10-30 parts of sesame and/or semen cassiae, 10-30 parts of sweet almond and 10-40 parts of astragalus membranaceus.
As a further improvement of the composition, the composition is as follows: 45-70 parts of plantain seed husk, 10-15 parts of fructus cannabis and/or konjac flour, 10-15 parts of sesame and/or semen cassiae and 10-15 parts of sweet almond; or
40-60 parts of plantain seed husk, 10-15 parts of fructus cannabis and/or konjac flour, 10-15 parts of sesame and/or semen cassiae, 10-15 parts of sweet almond and 10-15 parts of astragalus membranaceus.
As a further improvement of the above composition, the composition further comprises acceptable auxiliary materials.
As a further improvement of the composition, the composition is an oral preparation.
As a further improvement of the composition, the oral preparation is selected from solid beverage, solid powder, granule, tablet, capsule and oral emulsion.
A preparation method of a composition for relaxing bowel and losing weight comprises the following steps: weighing the raw materials according to the proportion of the composition, drying, crushing, and uniformly mixing to obtain the composition, wherein the composition is as described above.
As a further improvement of the above method, the raw materials are aged, dried and pulverized.
As a further improvement of the method, the cooking method is steaming or frying.
The invention has the beneficial effects that:
the composition is prepared by scientifically mixing various medicinal and edible food materials safe to human bodies or medicinal materials capable of being used as health-care products based on the basic theory of traditional Chinese medicines. The health-care food is fragrant in taste and rich in nutrition, has the effects of relaxing bowel and losing weight, has obvious curative effects on chronic constipation and obesity, and is suitable for various people to take.
Detailed Description
A composition for relaxing bowel and losing weight comprises the following effective raw materials in parts by weight:
30-70 parts of plantain seed husk, 10-40 parts of fructus cannabis and/or konjac flour, 10-30 parts of sesame and/or semen cassiae and 10-30 parts of sweet almond; or
30-60 parts of plantain seed husk, 10-40 parts of fructus cannabis and/or konjac flour, 10-30 parts of sesame and/or semen cassiae, 10-30 parts of sweet almond and 10-40 parts of astragalus membranaceus.
As a further improvement of the composition, the composition is as follows: 45-70 parts of plantain seed husk, 10-15 parts of fructus cannabis and/or konjac flour, 10-15 parts of sesame and/or semen cassiae and 10-15 parts of sweet almond; or
40-60 parts of plantain seed husk, 10-15 parts of fructus cannabis and/or konjac flour, 10-15 parts of sesame and/or semen cassiae, 10-15 parts of sweet almond and 10-15 parts of astragalus membranaceus.
The fructus Cannabis and rhizoma Amorphophalli powder can be used alone or in combination. The sesame and the cassia seed can be used independently or in a mixed way. For convenience of formulation, it is preferably used alone.
Plantago ovata seed husk, fructus Cannabis and/or rhizoma Amorphophalli powder, semen Sesami and/or semen Cassiae mainly act on large intestine, and have effects of loosening bowel to relieve constipation; sweet almond with the functions of ventilating lung and descending qi is added according to the exterior-interior theory of lung and large intestine in the traditional Chinese medicine, so that the effect of enhancing defecation is achieved; and then, the astragalus is added to further supplement qi and promote defecation. The effect of the composition can be further improved.
As a further improvement of the above composition, the composition further comprises acceptable auxiliary materials. Such excipients include, but are not limited to, flavoring agents, thickening agents, anti-caking agents, and the like.
As a further improvement of the composition, the composition is an oral preparation.
As a further improvement of the composition, the oral preparation is selected from solid beverage, solid powder, granule, tablet, capsule and oral emulsion. In particular, the oral preparation is solid beverage, and can be made into beverage by adding water and then taken orally.
A preparation method of a composition for relaxing bowel and losing weight comprises the following steps: weighing the raw materials according to the proportion of the composition, drying, crushing, and uniformly mixing to obtain the composition, wherein the composition is as described above.
As a further improvement of the above preparation method, the raw materials are aged, dried and pulverized. For raw materials which do not need to be cured, the raw materials can be directly mixed to prepare powder; or making into powder and mixing.
As a further improvement of the above preparation method, the cooking method is steaming or parching.
The technical scheme of the invention is further explained by combining the embodiment.
In the following examples, unless otherwise specified, the compositions were all steamed, dried, pulverized, mixed well, sterilized and bagged to obtain the products; the parts are all parts by mass unless otherwise specified.
Example 1:
a composition for relaxing bowel and losing weight comprises the following components: 50 parts of plantain seed husk, 15 parts of fructus cannabis, 15 parts of sesame and 10 parts of sweet almond.
Example 2:
a composition for relaxing bowel and losing weight comprises the following components: 70 parts of plantain seed husk, 10 parts of fructus cannabis, 30 parts of sesame, 10 parts of semen cassiae and 20 parts of sweet almond.
Example 3:
a composition for relaxing bowel and losing weight comprises the following components: 30 parts of plantain seed husk, 20 parts of fructus cannabis, 20 parts of konjac flour, 5 parts of sesame, 15 parts of semen cassiae and 20 parts of sweet almond.
Example 4:
a composition for relaxing bowel and losing weight comprises the following components: 45 parts of plantain seed husk, 10 parts of konjac flour, 15 parts of sesame and 10 parts of sweet almond.
Example 5:
a composition for relaxing bowel and losing weight comprises the following components: 60 parts of plantain seed husk, 13 parts of fructus cannabis, 10 parts of sesame and 15 parts of sweet almond.
Example 6:
a composition for relaxing bowel and losing weight comprises the following components: 30 parts of plantain seed husk, 20 parts of fructus cannabis, 10 parts of konjac flour, 20 parts of sesame, 20 parts of sweet almond and 20 parts of astragalus membranaceus.
Example 7:
a composition for relaxing bowel and losing weight comprises the following components: 60 parts of plantain seed husk, 15 parts of fructus cannabis, 25 parts of konjac flour, 5 parts of sesame, 10 parts of semen cassiae, 30 parts of sweet almond and 40 parts of astragalus membranaceus.
Example 8:
a composition for relaxing bowel and losing weight comprises the following components: 40 parts of plantain seed husk, 15 parts of konjac flour, 10 parts of sesame, 10 parts of sweet almond and 15 parts of astragalus membranaceus.
Example 9:
a composition for relaxing bowel and losing weight comprises the following components: 50 parts of Plantago ovata forsk husk, 10 parts of fructus cannabis, 15 parts of semen cassiae, 15 parts of sweet almond and 10 parts of astragalus membranaceus.
Example 10:
a composition for relaxing bowel and losing weight comprises the following components: 45 parts of plantain seed husk, 15 parts of fructus cannabis, 12 parts of sesame, 12 parts of sweet almond and 13 parts of astragalus membranaceus.
Example 11:
a composition for relaxing bowel and losing weight comprises the following components: 50 parts of plantain seed husk, 10 parts of fructus cannabis, 10 parts of sesame, 10 parts of sweet almond and 10 parts of astragalus membranaceus.
Example 12:
a composition for relaxing bowel and losing weight comprises the following components: 50 parts of plantain seed husk, 10 parts of fructus cannabis, 10 parts of sesame and 10 parts of sweet almond.
The technical scheme of the invention is further explained by combining experiments.
Effect of the compositions of the present invention on Chronic Constipation and obesity
After informed consent was obtained, 50 adults with chronic constipation were observed using the bowel relaxing, weight loss composition of the present invention.
The method comprises the following steps: the composition for relaxing bowel and losing weight of example 1 is taken once a day in the morning and at night, 9 g each time (comprising 5 g of Plantago ovata forsk seed husk, 1.5 g of fructus cannabis, 1.5 g of sesame and 1 g of sweet almond, mixed with boiled water to 400-500 mL, and taken after cooling) for 30 days continuously.
The stool frequency of 50 constipation patients is less than 3 times per week before taking the product, and the product meets the diagnosis standard of constipation. After the product is taken for 1 to 10 days, the excrement is 1 time per day or 1 time per two days; it is observed that 47 cases (94%) of the traditional Chinese medicine composition take 30 days, the excrement is 1-2 times every day, 3 cases (6%) of the traditional Chinese medicine composition take 1 time every two days, the disease condition is greatly relieved, and good clinical curative effect is achieved. No adverse reaction related to the product is observed during the administration of the product.
The concrete cases are as follows:
unless otherwise specified, the laxative diet food used in the following cases was the composition of example 1, and the method of use was: the medicine is taken once a day in the morning and at night, 9 g each time (including 5 g of Plantago ovata forsk husk, 1.5 g of fructus Cannabis, 1.5 g of sesame and 1 g of sweet almond, which are mixed with boiled water to 400-500 mL, and then the medicine is taken after being cooled).
Case 1: middle-aged women have long-term constipation and have 4-5 days of defecation, and need to take cathartics for a long time. After the food for relaxing bowel and losing weight is taken, the bowel is cleared up once every 8 days and once every 16 days after the food is taken, and the spirit is smooth.
Case 2: old men suffer from diabetes, hypertension and osteoporosis with constipation for 6 years, dry stool, and take laxatives for a long time in 3-4 days. After the food for relaxing bowel and losing weight is taken for 5 days, the shape of excrement is normal and smooth, and the time is 1-2 times per day.
Case 3: young women with height of 158cm and weight of 70kg dry stool for 2-3 days need to take cathartic for a long time. The health product for relaxing bowel and losing weight (the composition in the embodiment 11, which contains 5 g of Plantago ovata forsk seed husk, 1 g of fructus cannabis, 1 g of sesame, 1 g of sweet almond and 1 g of radix astragali, is taken after being mixed with boiled water to 400-500 mL and cooled). Starting on day 4, the shape of excrement is normal and smooth, 1-2 times a day, and the weight is 65kg on day 50 after the health-care product for relaxing bowel and losing weight is taken.
Effect of the compositions of the present invention on defecation in mice
The experimental scheme is as follows:
40 Kunming mice, male and female mice, the weight (20 +/-2 g) and 50 mice are randomly selected for constipation molding, after molding is successful, 30 mice are randomly selected and divided into model groups, administration groups without astragalus roots and administration groups with astragalus roots, 10 mice in each group and 10 mice without molding are used as blank control groups.
The molding medicine is compound diphenoxylate, and the dosage is 10 mg/kg;
the composition administered without astragalus was: 10 g of plantain seed husk, 3 g of fructus cannabis, 3 g of sesame and 2g of sweet almond;
the composition containing astragalus root is: plantago ovata seed husk 10 g, fructus cannabis 2g, sesame 2g, sweet almond 2g, astragalus root 2g (composition of example 11).
The treatment method comprises the following steps: the dose given to each mouse is 1.8g/kg, water is added to prepare 2ml per time of intragastric administration, and equal volume of physiological saline is respectively administered to the blank control group and the model group by intragastric administration.
The time to first bowel movement, number of bowel movement particles within 6h and stool shape were recorded after dosing. The results of the experiment are shown in table 1.
Table 1 effect of composition on constipation in mouse model defecation (n ═ 10)
Note: compared to the model group,: p<0.05. Compared with the group without radix astragali，#：P<0.05。
Compared with the group containing radix astragali#：P<0.01。
Effect of the composition of the invention on Constipation mouse intestinal motility
The experimental scheme is as follows:
kunming mice, male and female half, body weight (20 +/-2 g) and 30 mice are randomly divided into blank control groups, administration groups without astragalus and administration groups with astragalus, and 10 mice in each group.
The molding medicine is compound diphenoxylate, and the dosage is 10 mg/kg;
the composition administered without astragalus was: 10 g of plantain seed husk, 3 g of fructus cannabis, 3 g of sesame and 2g of sweet almond;
the composition containing astragalus root is: plantago ovata seed husk 10 g, fructus cannabis 2g, sesame 2g, sweet almond 2g, astragalus root 2g (composition of example 11).
The treatment method comprises the following steps: the dose given to each mouse is 1.8g/kg, water is added to prepare 2ml per time of intragastric administration, and the blank control group is administered with the same volume of physiological saline for intragastric administration. On the influence of constipation on the small intestine propulsion rate of mice, ink is given according to the gavage, animals are killed by cervical dislocation, the abdomen is opened, mesentery is separated, intestinal canals are cut, and the ink propulsion rate is calculated according to the classical ink propulsion test. The test results are shown in table 2.
Table 2 effect of composition on intestinal motility in mice (n ═ 10)
Note: compared to the blank control group,: p<0.05. Compared with the group without the astragalus root,#：P<0.05。
compared with the group containing radix astragali#：P<0.01。
The research on the dry feces number, the dilute feces number and the non-defecation animals of the compound diphenoxylate constipation model mouse shows that the model group has obvious difference compared with the dry feces numbers of all groups; the difference between the radix astragali-containing group and the radix astragali-free group of the product has statistical significance. The addition of radix astragali has better effect of improving constipation.
Compared with a blank control group, the product has significant difference in the aspect of the small intestine pushing rate of the mouse. Compared with the group without the radix astragali, the group with the radix astragali of the product has the advantages that the intestinal pushing rate of the mice is obviously improved, and the difference has statistical significance.
Claims (8)
1. A composition for relaxing bowel and losing weight comprises the following effective raw materials in parts by weight:
30-70 parts of plantain seed husk, 10-40 parts of fructus cannabis, 10-30 parts of sesame and 10-30 parts of sweet almond; or
30-60 parts of plantain seed husk, 10-40 parts of fructus cannabis, 10-30 parts of sesame, 10-30 parts of sweet almond and 10-40 parts of astragalus membranaceus.
2. The composition of claim 1, wherein: the raw materials comprise the following components in parts by weight:
45-70 parts of plantain seed husk, 10-15 parts of fructus cannabis, 10-15 parts of sesame and 10-15 parts of sweet almond; or
40-60 parts of plantain seed husk, 10-15 parts of fructus cannabis, 10-15 parts of sesame, 10-15 parts of sweet almond and 10-15 parts of astragalus membranaceus.
3. The composition of claim 1, wherein: also comprises acceptable auxiliary materials.
4. The composition according to any one of claims 1 to 3, characterized in that: the composition is an oral preparation.
5. The composition of claim 4, wherein: the oral preparation is selected from solid beverage, solid powder, granule, tablet, capsule, and oral emulsion.
6. A preparation method of a composition for relaxing bowel and losing weight comprises the following steps: weighing the raw materials according to the proportion of the composition, drying, crushing, and uniformly mixing to obtain the composition, wherein the composition is as defined in any one of claims 1 to 3.
7. The method of claim 6, wherein: aging the raw materials, drying, and pulverizing.
8. The method of claim 7, wherein: the cooking method is steaming or parching.
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| CN109619487A (en) * | 2018-10-26 | 2019-04-16 | 华中农业大学 | Composition and preparation method thereof with function of relaxing bowel |
| CN110214948A (en) * | 2019-07-07 | 2019-09-10 | 广州正广生物科技有限公司 | A kind of composition and preparation method thereof with function of relaxing bowel |
| CN110916184A (en) * | 2019-12-09 | 2020-03-27 | 雷允上药业集团有限公司 | Health product with function of relaxing bowels and preparation method thereof |
| CN113439807A (en) * | 2020-03-25 | 2021-09-28 | 广州万康保健品有限公司 | Beverage for losing weight and preparation method thereof |
| CN111298021A (en) * | 2020-04-07 | 2020-06-19 | 湖南中医药大学第一附属医院((中医临床研究所)) | Traditional Chinese medicine composition for treating functional constipation |
| CN116138454B (en) * | 2021-11-19 | 2024-04-16 | 宁夏枸杞创新中心(有限公司) | Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof |
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| CN104258045B (en) * | 2014-09-25 | 2017-08-22 | 苏州市天灵中药饮片有限公司 | A kind of Chinese medicine relaxed bowel and preparation method thereof |
| CN105211687A (en) * | 2015-10-20 | 2016-01-06 | 汤臣倍健股份有限公司 | A kind of composition and method of making the same and purposes |
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