CN110214948A - A kind of composition and preparation method thereof with function of relaxing bowel - Google Patents
A kind of composition and preparation method thereof with function of relaxing bowel Download PDFInfo
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- CN110214948A CN110214948A CN201910607378.0A CN201910607378A CN110214948A CN 110214948 A CN110214948 A CN 110214948A CN 201910607378 A CN201910607378 A CN 201910607378A CN 110214948 A CN110214948 A CN 110214948A
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 230000002040 relaxant effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims description 10
- 239000000843 powder Substances 0.000 claims abstract description 38
- 229920001202 Inulin Polymers 0.000 claims abstract description 21
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 21
- 229940029339 inulin Drugs 0.000 claims abstract description 21
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- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims abstract description 10
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- 241001672694 Citrus reticulata Species 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
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- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
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- 229940079593 drug Drugs 0.000 description 4
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- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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- 241000186000 Bifidobacterium Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
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- 230000000378 dietary effect Effects 0.000 description 1
- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
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- 239000004310 lactic acid Substances 0.000 description 1
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- 239000008141 laxative Substances 0.000 description 1
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- 230000001050 lubricating effect Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of compositions with function of relaxing bowel, including component below: circle bud 80-100 parts of Cillium, 1-10 parts of hawthorn freeze-dried powder, 1-5 parts of brush-cherry seed, 1-5 parts of fructus cannabis, 5-10 parts of radish seed, 1-5 parts of almond, 30-60 parts of galactooligosaccharide, 20-40 parts of lactitol, 30-50 parts of Oligomeric manna sugar, 10-20 parts of inulin, 1-15 parts of Arabic gum, 5-10 parts of Semen Tritici aestivi fiber, 5-10 parts of citrus fruit fibres, 1-5 parts of black sesame powder.The composition can significantly enhance the effect of relax bowel and defecation, promote the wriggling of stomach and intestine, promote defecation, shorten the time of defecation, reduce the dead time of excrement, softer stool promotes the movement of enteron aisle, adjusts the distribution of intestinal flora.
Description
Technical field
The present invention relates to healthy food fields, and in particular to a kind of with the composition of function of relaxing bowel and its preparation side
Method.
Background technique
It is a kind of common stubborn disease in Chinese constipation, often understands obstinate, constipation and the living habit of human body have
Much relations, for example diet is irregular, bowl evacuation habit is bad, enteron aisle lesion etc..The drug for the treatment of constipation at present has purgatives, actuates
Power class drug, succagoga etc., such as glycerol, magnesium sulfate, paraffin, however the use of these drugs frequently can lead to enteric nervous
The change of irritability will lead to form dependence to drug on long terms, or even enteron aisle can be made to lose normal digestion defecation etc.
Function.
Other than Western medicine, relatively common at present also Chinese medicine therapy and biofeedback therapy, however gradually appear at present
Out the drawbacks of, is also obvious, such as body electrolyte imbalance, inflammatory reaction, Dysbiosis etc..
The mode for the improvement constipation relatively approved at present is the dietary food product that supplement has function of relaxing bowel, such as
CN201710171404, which discloses the relax bowel and defecation that a kind of therapeutic effect, the course for the treatment of is shorter, has no toxic side effect, improves constipation food, including
The luxuriant Cillium of inulin, circle, oligofructose, xylo-oligosaccharide, steviol glycoside and resistant dextrin, have good improvement constipation effect
Fruit promotes the digestion of stomach.
CN201610200045 discloses a kind of relax bowel and defecation, improves human body intestinal canal flora distribution, adjusts intestinal health
Composition, including circle luxuriant Cillium, inulin, branches and certain mines such as hydroxy or carboxy of institute's band in circle bud Cillium
The combination of substance will affect the balance in human body intestinal canal, and inulin can promote the absorption of minerals, and the two complementation is bringd into play ease constipation
The effect of defaecation.
Summary of the invention
The purpose of the present invention is to provide a kind of composition with enhancing effect of relaxing bowel, the purposes packets of the composition
When including the stagnation of improvement intestinal flora distributed architecture, the growth of promotion probiotics, adjusting intestinal health, improvement excrement in enteron aisle
Between and softer stool etc., technical scheme is as follows.
A kind of composition with function of relaxing bowel, including Chinese herbaceous peony platymiscium, dietary fiber and oligosaccharide, the vehicle
Preceding platymiscium refers to the luxuriant Cillium of circle.
Cillium luxuriant for circle, dietary fiber and oligosaccharide, respective effect is well known in the art, circle bud
Cillium can adequately absorb moisture, increase the agglomerate that volume can extremely drain, increase the wriggling of enteron aisle.Dietary fiber can
To increase the moisture holding capacity of excrement, promotes intestines peristalsis, increase the effect of relax bowel and defecation.Oligosaccharide is that the beneficial bacterium in enteron aisle is double
The nutriment of discrimination bacillus growth, Bifidobacterium can generate the metabolites such as lactic acid, acetic acid using oligosaccharide, can inhibit to produce
The growth and breeding of the harmful bacterias such as gas bacillus capsulatus and coliform promotes the compacted of enteron aisle to inhibit the generation of ammonia, indoles substance
It is dynamic.
For the present invention, the selection of above-mentioned substance is the basic work of the present invention, and the present invention further studies
It discusses and improves relax bowel and defecation effect, such as improve the effect of lubrication excrement, enhancing intestinal motility.
Further, composition of the invention further includes one of brush-cherry seed, fructus cannabis, radish seed, almond or a variety of,
And/or composition further includes one of inulin, hawthorn freeze-dried powder and black sesame powder or a variety of.
As mentioned in background technique, the compatibility of inulin and the luxuriant Cillium of circle can promote to mutually promote, and play very well
Relax bowel and defecation effect, dietary fiber and oligosaccharide can promote the wriggling of enteron aisle.However find under study for action, the inulin and
Two kinds of combinations of circle bud Cillium and the luxuriant Cillium of circle, dietary fiber, oligosaccharide there is also certain disadvantage,
Including lubrication excrement, softer stool and shorten dead time of the excrement in enteron aisle.
Therefore as one of important innovations point of the invention, the present invention selects the addition of hawthorn freeze-dried powder, black sesame powder, to change
The above-mentioned function of kind circle bud Cillium, inulin, oligosaccharide and dietary fiber.
A kind of composition with function of relaxing bowel, including the luxuriant Cillium of circle, inulin, oligosaccharide, dietary fiber,
Hawthorn freeze-dried powder, black sesame powder.Compared to above-mentioned basic formula, which can significantly promote defecation and softening and lubrication
Excrement.
The dosage form of composition of the present invention is tablet, mouth containing agent, pulvis, electuary, capsule, powder, pill.
Preferably, composition of the invention further includes one of brush-cherry seed, fructus cannabis, radish seed, almond or a variety of, spy
Composition not of the invention further includes brush-cherry seed, fructus cannabis, radish seed, almond.
Residence time is more long in vivo for excrement, more unfavorable to health, it is however generally that, it, can if 3 days do not defecate
Cause big enteral to pile with the remnants of 4-6, makes one uncomfortable.Under normal circumstances, wriggling 2-3 is returned large intestine per minute, if bradystalsis
It is excessive to will lead to moisture absorption, so that stool is hardened and constipation occurs, moves equally too fast, then will lead to moisture and have little time to inhale
It receives and diarrhea just occurs.
It is even in the case where taking the diet for long periods of time for the composition of function of relaxing bowel based on above-mentioned research
There is the case where diarrhea-like feces, and then obviously also will affect the health degree of body in case of diarrhea, and then human body can be reduced
Immunity.
Therefore, too fast based on not will lead to intestinal peristalsis, it ensures and normal stool is adjusted to by constipation, the present invention adds institute
Brush-cherry seed, fructus cannabis, radish seed, the almond stated are particularly significant.
Brush-cherry seed has the function of relax bowel and defecation, plays Li Shui down, and fructus cannabis has effects that beneficial spleen qi-restoratives, moisturizing dryness and lubricating intestine,
Radish seed has effects that sending down abnormally ascending defaecation, slit phlegm are allayed excitement；Almond also has the function of relax bowel and defecation.Other than above-mentioned effect,
For example almond has effects that promote the production of body fluid to quench thirst, fructus cannabis has effects that nourish qi-restoratives.State in the choice constituent adjustment enteron aisle,
While relax bowel and defecation, additionally it is possible to immunity, the resistance of further adjustment human body, it is ensured that the composition can be in reality
While existing relax bowel and defecation, the generation of diarrhea is also avoided.
Therefore, as optimal scheme, the present invention relates to a kind of composition with function of relaxing bowel, including it is below
Component: circle bud 80-100 parts of Cillium, 1-10 parts of hawthorn freeze-dried powder, 1-5 parts of brush-cherry seed, 1-5 parts of fructus cannabis, radish seed 5-
10 parts, 1-5 parts of almond, 15-60 parts of galactooligosaccharide, 20-40 parts of lactitol, 15-50 parts of Oligomeric manna sugar, 10-20 parts of inulin,
1-15 parts of Arabic gum, 5-10 parts of Semen Tritici aestivi fiber, 5-10 parts of citrus fruit fibres, 1-5 parts of black sesame powder.
Further, the composition of the function of relaxing bowel is made of the following components: circle bud Cillium 85-95
Part, 3-6 parts of hawthorn freeze-dried powder, 1-3 parts of brush-cherry seed, 1-3 parts of fructus cannabis, 5-8 parts of radish seed, 2-5 parts of almond, galactooligosaccharide
40-50 parts, 20-35 parts of lactitol, 35-45 parts of Oligomeric manna sugar, 10-15 parts of inulin, 1-5 parts of Arabic gum, Semen Tritici aestivi fiber 5-8
Part, 5-8 parts of citrus fruit fibres, 1-3 parts of black sesame powder.
Further, the composition further includes the one or more of following conventional auxiliary material: sweetener, essence, tax
Type agent, lubricant, adhesive, disintegrating agent.
Further, the composition can be processed as the dosage form of this field routine, including but not limited to tablet, mouth containing
Agent, pulvis, electuary, capsule, powder, pill.
The invention further relates to the preparation method of the composition with function of relaxing bowel, in comprising the following steps that
(1) weigh each raw material of the formula ratio in addition to Arabic gum, it is dry, crush, cross 80-100 mesh, weigh formula ratio Ah
Primary glue is drawn, it is spare；
(2) above-mentioned part material is grouped premixing, respectively hawthorn freeze-dried powder, black sesame powder and inulin is uniformly mixed, Yu Li
Benevolence, fructus cannabis, radish seed, almond are uniformly mixed, and galactooligosaccharide, lactitol and Oligomeric manna sugar are uniformly mixed, Semen Tritici aestivi fiber
It is uniformly mixed with citrus fruit fibres；
(3) raw material and other raw materials being pre-mixed step (2) using three-dimensional mixer are uniformly mixed, and incorporation time control exists
25-40min obtains powder mixture.
Further, the composition can further be processed as the dosage form of this field routine, including but not limited to
Tablet, mouth containing agent, pulvis, electuary, capsule, powder, pill.
Purposes of the composition of the present invention in the composition that preparation has enhancing function of relaxing bowel, the group
The function of closing object includes improving intestinal flora distributed architecture, the growth for promoting probiotics, adjusting intestinal health, improve excrement in intestines
Dead time and softer stool in road.
The invention has the benefit that the present invention can significantly enhance the effect of relax bowel and defecation, promote the wriggling of stomach and intestine,
Promote defecation, shorten the time of defecation, reduce the dead time of excrement, softer stool promotes the movement of enteron aisle, adjusts enterobacteriaceae
The distribution of group promotes the growth of probiotics, adjusts body immunity and resistance, increases the comfort of stomach, avoid taking and lead
The occurrence of diarrhea of cause, will not result in the dependence of product, realize the effect of long-term intestinal health.
Specific embodiment
Embodiment 1
A kind of composition with function of relaxing bowel, including luxuriant 90 parts of the Cillium of circle, 12 parts of dietary fiber and oligosaccharide
40 parts.
Embodiment 2
A kind of composition with function of relaxing bowel, including luxuriant 90 parts of the Cillium of circle, 10 parts of inulin, 40 parts of oligosaccharide,
12 parts of dietary fiber, 4 parts of hawthorn freeze-dried powder, 1 part of black sesame powder.
Embodiment 3
A kind of composition with function of relaxing bowel, including component below: 100 parts of Cillium of circle bud, hawthorn freeze-drying
It is 1.5 parts of powder, 1 part of brush-cherry seed, 1.5 parts of fructus cannabis, 5 parts of radish seed, 1 part of almond, 15 parts of galactooligosaccharide, 20 parts of lactitol, low
15 parts of poly- mannose, 10 parts of inulin, 2 parts of Arabic gum, 6 parts of Semen Tritici aestivi fiber, 5 parts of citrus fruit fibres, 1.5 parts of black sesame powder.
Embodiment 4
A kind of composition with function of relaxing bowel, including component below: circle bud 95 parts of Cillium, hawthorn freeze-dried powder
2 parts, 2 parts of brush-cherry seed, 2 parts of fructus cannabis, 5 parts of radish seed, 1 part of almond, 20 parts of galactooligosaccharide, 22 parts of lactitol, oligomeric sweet dew
Sugared 18 parts, 11 parts of inulin, 1 part of Arabic gum, 6 parts of Semen Tritici aestivi fiber, 6 parts of citrus fruit fibres, 1.8 parts of black sesame powder.
Embodiment 5
The preparation method of composition of relax bowel and defecation, (1) weigh each raw material of the formula ratio in addition to Arabic gum, which can be with
It is the component proportion dosage of embodiment 3 or embodiment 4, dry, crushing crosses 80-100 mesh, weighs the Arabic gum of formula ratio,
It is spare；
(2) above-mentioned part material is grouped premixing, respectively hawthorn freeze-dried powder, black sesame powder and inulin is uniformly mixed, Yu Li
Benevolence, fructus cannabis, radish seed, almond are uniformly mixed, and galactooligosaccharide, lactitol and Oligomeric manna sugar are uniformly mixed, Semen Tritici aestivi fiber
It is uniformly mixed with citrus fruit fibres；
(3) raw material and other raw materials being pre-mixed step (2) using three-dimensional mixer are uniformly mixed, and incorporation time control exists
25-40min obtains powder mixture.
Innovation according to the present invention is respectively provided with following comparative test.
Comparative example 1
The composition of relax bowel and defecation, including circle luxuriant 35 parts of Cillium, 16 parts of haw thorn extract, 10 parts of xylo-oligosaccharide.
Comparative example 2
The composition of relax bowel and defecation, circle bud Cillium 680g, inulin 100g, white granulated sugar 200g, Arabic gum 20g.
Comparative example 3
Composition with function of relaxing bowel, including component below: circle bud 100 parts of Cillium, galactooligosaccharide 15
Part, 20 parts of lactitol, 15 parts of Oligomeric manna sugar, 10 parts of inulin, 2 parts of Arabic gum, 6 parts of Semen Tritici aestivi fiber, 5 parts of citrus fruit fibres.
Test measurement examines the effect with the measurement relax bowel and defecation of assessment technique specification according to health food.
Experiment one, mouse small intestine movement effects
Principle: modeling medicaments compound diphenoxylate is given in oral stomach-filling, establishes mouse small intestine wriggling and inhibits model, calculates a timing
The ink progradation of interior small intestine, judgment models Mouse Stomach Intestinal motility.
Subjects select SPF grades of male mices, weight 20 ± 2g, and every group 18；
The preparation of prepared Chinese ink accurately weighs Arabic gum 100g, adds water 800ml, boils transparent to solution, weighs active carbon 50g and adds
To boiling 3 times in above-mentioned solution, after solution is cool plus water constant volume arrives 1000ml, saves for 4 DEG C in refrigerator, with before shaking up.
The preparation of compound diphenoxylate suspension, concentration 0.025% take R-1132 25mg, are ground with mortar
In adding water to 100ml, prepared before use after powder.
Dosage grouping and given the test agent give the time.With 10 times of human body recommended amounts for dosage group, setting blank control group,
Model group and experimental group, given the test agent give the time be 10 days.
Model foundation: to after given the test agent 5 days or 7 days, each group mouse is deprived of food but not water 16 hours.Multimodel experiment group
Compound diphenoxylate (5mg/kg BW) is given in stomach-filling, and blank control group gives distilled water.
The method of index determining
After 0.5h after compound diphenoxylate, experimental group gives the prepared Chinese ink containing corresponding given the test agent respectively.
Cervical dislocation puts to death animal immediately after 25 minutes, opens abdominal cavity and separates mesenterium, clip upper end is extremely returned from pylorus, lower end
The intestinal tube in blind portion, is placed on pallet, and small intestine is lightly pulled into straight line, and measurement Length of intestine is total small intestinal length, from pylorus to
Prepared Chinese ink forward position is that prepared Chinese ink promotes length, calculates ink progradation according to following formula.
Ink progradation (%)=prepared Chinese ink promotes length (cm)/total small intestinal length (cm) * 100%
Following table is to give the influence to mouse small intestine movement in given the test agent 5 days
Following table is to give the influence to mouse small intestine movement in given the test agent 7 days
It is of the invention it can be seen from Tables 1 and 2 that there is significant impact, especially embodiment 3 for improving intestinal motility
Group, effect become apparent.
Experiment two, defecation time for the first time, experimental method are examined referring to health food and are carried out with value disciplines.Weight of the present invention
Point has studied first grain row's melena time of embodiment 1-3, the results showed that (the experimental group of 7d of defecation time for the first time of embodiment 1-3
In), first grain row's melena time of embodiment 1-3 is 30.1 ± 8.1min, 21.2 ± 7.9min and 15.3 ± 6.7min.As a result table
After being added to hawthorn freeze-dried powder and black sesame powder in the bright present invention, and represent the embodiment of the present invention 3 with good effect,
Reflecting composition of the invention on the whole has good relax bowel and defecation effect.
Experiment three, separately sets experimental group, model foundation with above-mentioned experiment one, study embodiment 3 and comparative example 3 7d,
There is the case where diarrhea in 15d, 30d.
The experimental results showed that embodiment 3 is happened in 7-30d without diarrhea, and comparative example 3 has 2 diarrhea situations in 15d
Occur, has the case where 6 diarrhea in 30d.It can thus be seen that composition of the invention is improving the same of relax bowel and defecation
When, the case where capable of further improving aperient effects to normal situation, can be avoided diarrhea generation.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (9)
1. a kind of composition with function of relaxing bowel, it is characterised in that including Chinese herbaceous peony platymiscium, dietary fiber and oligosaccharide.
2. as described in claim 1 with the composition of function of relaxing bowel, it is characterised in that the Chinese herbaceous peony platymiscium is
Refer to the luxuriant Cillium of circle.
3. the composition according to claim 1 or 2 with function of relaxing bowel, it is characterised in that the composition
Dosage form is tablet, mouth containing agent, pulvis, electuary, capsule, powder, pill.
4. the composition according to claim 2 with function of relaxing bowel, it is characterised in that the composition also wraps
Include one of brush-cherry seed, fructus cannabis, radish seed, almond or a variety of.
5. the composition according to claim 1 with function of relaxing bowel, it is characterised in that the composition also wraps
Include one of inulin, hawthorn freeze-dried powder and black sesame powder or a variety of.
6. a kind of composition with function of relaxing bowel, it is characterised in that including component below: circle bud Cillium 80-
100 parts, 1-10 parts of hawthorn freeze-dried powder, 1-5 parts of brush-cherry seed, 1-5 parts of fructus cannabis, 5-10 parts of radish seed, 1-5 parts of almond, oligomeric half
30-60 parts of lactose, 20-40 parts of lactitol, 30-50 parts of Oligomeric manna sugar, 10-20 parts of inulin, 1-15 parts of Arabic gum, wheat are fine
Tie up 5-10 parts, 5-10 parts of citrus fruit fibres, 1-5 parts of sesame oil powder.
7. the composition according to claim 6 with function of relaxing bowel, it is characterised in that the composition also wraps
Include the one or more of the auxiliary material of following routine: sweetener, essence, excipients, lubricant, adhesive, disintegrating agent.
8. the preparation method of composition as claimed in claim 6 with function of relaxing bowel, it is characterised in that including following step
It is rapid: (1) to weigh each raw material of the formula ratio in addition to Arabic gum, dry, crushing crosses 80-100 mesh, weighs the Ah of formula ratio
Primary glue is drawn, it is spare；
(2) above-mentioned each raw material being grouped premixing, respectively hawthorn freeze-dried powder, black sesame powder and inulin is uniformly mixed, brush-cherry seed,
Fructus cannabis, radish seed, almond are uniformly mixed, and galactooligosaccharide, lactitol and Oligomeric manna sugar are uniformly mixed, Semen Tritici aestivi fiber and mandarin orange
Tangerine fiber is uniformly mixed；
(3) raw material and other raw materials being pre-mixed step (2) using three-dimensional mixer are uniformly mixed, and incorporation time control exists
25-40min obtains powder mixture.
9. purposes of the composition as claimed in claim 6 in the composition that preparation has enhancing function of relaxing bowel, described
The function of composition include improve intestinal flora distributed architecture, promote probiotics growth, adjust intestinal health, improve excrement exist
Dead time and softer stool in enteron aisle.
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| CN112617204A (en) * | 2020-12-15 | 2021-04-09 | 山东欣瑞文生物科技有限公司 | Arabic gum composition with bowel relaxing and constipation relieving effects |
| CN112641098A (en) * | 2020-12-15 | 2021-04-13 | 山东欣瑞文生物科技有限公司 | Arabic gum composition with function of conditioning gastrointestinal diarrhea |
| WO2022016774A1 (en) * | 2020-07-23 | 2022-01-27 | 江西人之初乳品营养有限公司 | Composition beneficial for regulating intestinal tract, promoting digestion and improving constipation, and preparation method therefor |
| CN114246334A (en) * | 2021-12-29 | 2022-03-29 | 新乡绿健园药食同源研究院有限公司 | Meal replacement powder with bowel relaxing effect and preparation method thereof |
| CN114947031A (en) * | 2022-05-16 | 2022-08-30 | 四川藏启元健康管理有限公司 | Plant compound solid beverage capable of relaxing bowels and preparation method thereof |
| CN115553365A (en) * | 2022-10-17 | 2023-01-03 | 霸符(杭州)科技有限公司 | Functional soft candy capable of improving constipation and preparation method thereof |
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