CN104800487B - It is a kind of to be used to treat traditional Chinese medicinal ointment of chronic constipation and preparation method thereof - Google Patents
It is a kind of to be used to treat traditional Chinese medicinal ointment of chronic constipation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of traditional Chinese medicinal ointment and preparation method thereof for being used to treat chronic constipation, solves the problems, such as that the Chinese medicine for treating chronic constipation has that toxic side effect is big, easy formation pharmacological dependence.The present invention includes：18~22 parts of saline cistanche, 18~22 parts of the bighead atractylodes rhizome, 25~30 parts of the Radix Astragali, 25~30 parts of Radix cynanchi wilfordii, 12~15 parts of radix scrophulariae, 18~22 parts of radish seed, 8~12 parts of Chinese yam, 12~15 parts of the membrane of a chicken's gizzard, 12~15 parts of black sesame powder, 8~12 parts of radix cyathulae, 12~15 parts of Divine Comedy, 8~12 parts of donkey-hide gelatin, 45~50 parts of refined honey.All medicines share of the present invention, medication is exquisite, compatibility is proper, tonification and purgation in combination, the effect of improving treatment chronic constipation Chinese medicine well, and any toxic side effect is both not present in it, also be not in pharmacological dependence, therefore, the present invention has very high application value, suitable for popularization and application.
Description
Technical field
The present invention relates to a kind of traditional Chinese medicinal ointment, and in particular to be a kind of to be used to treat traditional Chinese medicinal ointment and its preparation of chronic constipation
Method.
Background technology
It is more to treat the Chinese medicine preparation species of chronic constipation on the market at present, there is pill (such as Maren wan, hemp intestine-moistening
Ball), capsule (such as toxin-discharging nourishing capsule, aloe capsule), oral liquid (such as Qirong Runchang Oral Liquid) and Chinese medicine preparation, etc.
Deng.
Patent No. ZL97106911.5, entitled " a kind of intestines for being used to treat chronic constipation lead to peaceful Chinese medicine " disclose
A kind of Chinese medicine that can treat constipation, its Chinese medicine preparation is mainly by 13 taste medicines such as saline cistanche, the raw bighead atractylodes rhizome, radix rehmanniae recen, Bin youth, radix scrophulariaes
Composition, has the advantages that kidney-nourishing ease constipation, tonifying Qi enriching yin, nourshing blood and promoting blood circulation, is adapted to treatment chronic constipation.And the patent No.
ZL201210198626.9, denomination of invention " a kind of traditional Chinese medicine lotion preparation method for treating constipation type trichomonas vaginitis " then provide
A kind of traditional Chinese medicine lotion, it is mainly soaked through water by the taste medicine of patience dock root, folium sennae, cape jasmine, the Fructus Sophorae, garden burnet etc. 27, is cooked by slow fire
System, filtration step are made, and have the advantages of short treating period, cure rate are high, can avoid producing adverse reaction using Western medicine.
Above two medicine, due to containing rhubarb in the former, folium sennae is contained in the latter, and both components are to contain
There is the medicine of the chemical compositions such as anthraquinone derivative, sennoside, aloe-emodin, thus above two Chinese medicine mainly passes through stimulation
Large intestine, promote intestinal peristalsis and defecation, so as to realize its defaecation purpose.If however, long-term use of such medicine, to enteron aisle meeting
There are significantly damages, slight, Melanosis coli can be caused；It is serious, it may appear that the constipation of purgatives dependence, colon paralysed disease,
The consequences such as atony of colon.Therefore, the toxic side effect of above two medicine is all more obvious, unsuitable long-term use of.
In summary, how existing treatment constipation, the particularly Chinese medicine preparation of chronic constipation are improved, become for
The subject matter of those skilled in the art's urgent need to resolve.
The content of the invention
It is an object of the invention to provide a kind of traditional Chinese medicinal ointment for being used to treat chronic constipation and preparation method thereof, mainly solve
The problem of toxic side effect greatly, easily forms pharmacological dependence be present in the Chinese medicine of existing treatment chronic constipation.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of traditional Chinese medicinal ointment for being used to treat chronic constipation, including the material that number is following：18~22 parts of saline cistanche, the bighead atractylodes rhizome 18
~22 parts, 25~30 parts of the Radix Astragali, 25~30 parts of Radix cynanchi wilfordii, 12~15 parts of radix scrophulariae, 18~22 parts of radish seed, 8~12 parts of Chinese yam, chicken
Interior golden 12~15 parts, 12~15 parts of black sesame powder, 8~12 parts of radix cyathulae, 12~15 parts of Divine Comedy, 8~12 parts of donkey-hide gelatin, refined honey 45~
50 parts.
Further, present invention additionally comprises the following material of number：18~22 parts of rhizoma alismatis, 8~12 parts of peach kernel, rattletop 8~
12 parts, 8~12 parts of Fructus Aurantii, 8~12 parts of Radix Angelicae Sinensis.
On the basis of mentioned component, present invention also offers the preparation side that this is used to treat the traditional Chinese medicinal ointment of chronic constipation
Method, comprise the following steps：
(1) raw material is prepared：18~22 parts of saline cistanche, 18~22 parts of the bighead atractylodes rhizome, 25~30 parts of the Radix Astragali, 25~30 parts of Radix cynanchi wilfordii,
12~15 parts of radix scrophulariae, 18~22 parts of radish seed, 8~12 parts of Chinese yam, 12~15 parts of the membrane of a chicken's gizzard, 12~15 parts of black sesame powder, river ox
8~12 parts of knee, 12~15 parts of Divine Comedy, 8~12 parts of donkey-hide gelatin, 45~50 parts of refined honey；
(2) it is saline cistanche, the bighead atractylodes rhizome, the Radix Astragali, Radix cynanchi wilfordii, radix scrophulariae, radish seed, Chinese yam, the membrane of a chicken's gizzard, radix cyathulae, Divine Comedy is each
Self-watering continuously decocts three times, and the number of the water added every time is identical with the number of material, and the time decocted for the first time is extremely
It is 3h less, second of the time decocted with third time is at least 1.5h；
(3) after decocting, all decocting liquids in step (2) are mixed, and filtered, obtain filtrate；
(4) clear cream shape is concentrated the filtrate to, and adds donkey-hide gelatin and black sesame powder mixing, obtains secondary mixture；
(5) it is 1.25~1.30g/cm secondary mixture to be concentrated into density3Clear cream；
(6) add and refined honey and mix in clear cream, obtain traditional Chinese medicinal ointment, the portion rate of the clear cream and refined honey is 2: 1.
Further, in the step (1), the raw material of preparation also includes：18~22 parts of rhizoma alismatis, 8~12 parts of peach kernel, rattletop
8~12 parts, 8~12 parts of Fructus Aurantii, 8~12 parts of Radix Angelicae Sinensis.
Compared with prior art, the invention has the advantages that：
(1) present invention is based on saline cistanche, the bighead atractylodes rhizome, the Radix Astragali and radix scrophulariae, and combines other components, then by reasonably matching somebody with somebody
Square ratio and preparation technology are prepared to obtain.Card type of the present invention is clear and definite, it is determined that the card type for triggering chronic constipation is syndrome of yang deficiency of spleen and kidney, or
Based on syndrome of yang deficiency of spleen and kidney, the reinforcing method of asthenic symptoms can not be anxious, it is necessary to and mended to be slow, any purgatives need not be added in inventive formulation, its
It is a small amount of repeatedly to take for a long time after paste is made, body equilibrium between yin and yang just can be gradually adjusted, promotes rehabilitation, recovers patient
Normal defecation physiology function.
(2) in inventive formulation, the sweet saltiness temperature of saline cistanche, function warm kidney strengthening the essence, relax bowel, in side containing glycine betaine,
A variety of chemical compositions such as ergosterol, daucosterol, mannitol, have and suppress big intestinal absorption moisture content, improve small intestine push degree, contracting
Short defecation time, the increase effect such as spleen and thymic factor D injection, are monarch drug in a prescription；Bighead atractylodes rhizome sweetness and bitterness is warm-natured, function air making-up and spleen enlivening eliminating dampness, together
When, also there is strong work containing chemical compositions such as atractylol, atractyloxide, atractyloide, fructose and several amino acids in side
With the effect such as bidirectional modulation intestinal tube activity, promotion cellular immune function；The sweet tepor of the Radix Astragali, function tonifying spleen lung qi, rising Yang are lifted
Fall into, enrich blood, invigorate blood circulation, meanwhile, also have containing chemical compositions such as glycoside, polysaccharide, flavone compounds in side and promote body generation
Thank, it is antifatigue, increase in body intestines tensity, promote hematopoiesis function, act on cell growth and regeneration etc..The Radix Astragali, the bighead atractylodes rhizome share,
Complement each other, add invigoration spleen qi, tonifying Qi and blood, the work(of spreading body fluid, while also improve the work(of saline cistanche warm kidney strengthening the essence
Effect, body fluid is unimpeded, and internal organs must moisten, then defecation is unobstructed.And radix scrophulariae bitter sweet saltiness is micro- salty, function clearing heat and cooling blood, nourishing Yin and falling fire, purging intense heat
Removing toxic substances, meanwhile, the chemical compositions such as harpagide, harpagide member, aucubin, alkaloid, phytosterol, oleic acid are contained in side,
With antibacterial, anti-inflammatory, calmness, anticonvulsion etc. act on, with said medicine with use, tonification and purgation in combination, can reach righting with sharp eliminating evil,
Attack evil without hindering positive effect.
(3) spleen-and-stomach-invigorating composition (Chinese yam, Divine Comedy, the membrane of a chicken's gizzard, Radix cynanchi wilfordii), Multiple components phase are also contained in inventive formulation
Interaction, the function of taste can be strengthened.And because taste are middle Jiao, it is the terminal of drug absorption, after oral drugs, if not
Absorption can be digested well, then medicine is difficult to play corresponding effect, and therefore, the present invention is during preparation, by more
The mutual cooperation of kind medicine, react to each other, the active ingredient in obtained traditional Chinese medicinal ointment is lifted taste well to medicine
Digestion and absorbability, and then the effect of ensure that whole traditional Chinese medicinal ointment.
(4) radix cyathulae in inventive formulation has invigorate blood circulation, filling liver kidney, strengthening the bones and muscles, promoting diuresis for stranguria, ignited under (blood)
OK, be important guiding drug thing, by inventive formulation the property of medicine introduce kidney channel, can be apt to its power it is descending, beneficial to defaecation.And because
Blood is one of basic substance for forming human body and maintaining human life activity, and any position of human body lacks the keeping of blood, can
Its normal physiological activity is influenceed, so the present invention has also coordinated donkey-hide gelatin to be enriched blood, stopped blooding, grown while using radix cyathulae
It is cloudy；Again because gas is the power of blood generation and operation, and inventive formulation is to mend the prescription to rush down, substantial amounts of tonic
Thing enters body through opening middle Jiao, enters kidney channel by guiding drug, and therefore, in order to ensure curative effect of medication gives full play to, the present invention adds
Radish seed is entered, has been acted on and promoted using the powerful promoting the circulation of qi of radish seed, realize the promoting the circulation of qi that helps digestion, the purpose of lowering the adverse-rising QI to resolve phlegm.
(5) the various drug ingedients of the present invention complement each other, combined closely, and all medicines share, medication is exquisite, compatibility is proper, attacks
Mend it is simultaneous apply, improve well Chinese medicine to treatment chronic constipation in terms of the effect of.The present invention is not only quick, has no toxic side effect,
And any pharmacological dependence will not be produced, curative effect is all good, is to treat the good recipe of constipation.The present invention is especially suitable for slow
Property intractable constipation, the constipation of purgatives dependence, constipation in children, elderly constipation, puerperal constipation and constipation postoperative rehabilitation, thus its
With very extensive application prospect.
Embodiment
With reference to embodiment, the invention will be further described, and embodiments of the present invention include but is not limited to following reality
Apply example.
Embodiment
Constipation is as caused by many reasons, and clinic point card is complicated, wherein based on asthenic symptoms, and asthenic symptoms are with spleen, kidney yang
Void, the deficiency of vital energy, it is cold solidifying based on, be often mingled with the deficiency of blood, the deficiency of Yin, the stagnation of the circulation of vital energy, thermojunction.The liquid of kidney master five, take charge of folding, the spleen transporting the nutritious substance in the stomach
Person.Kidney deficiency folding mistake department, foul smell do not drop, and temper is weak, constraint body fluid must not four cloth, enteron aisle lose profit, constipation, stasis is in intestines
Internal organs, the stagnation of the circulation of vital energy, thermojunction, the deficiency of Yin, the deficiency of blood can be caused；Control and work as warm kidney strengthening the essence, tonifying Qi and blood, relax bowel.
Based on above-mentioned factor, the invention provides the traditional Chinese medicinal ointment after a kind of improvement, its have warm kidney strengthening the essence, tonifying Qi and blood,
The effect of relaxing bowel, it can be used for treating constipation, particularly chronic constipation disease.The formula components of the present invention include meat desert
Rong, the bighead atractylodes rhizome, the Radix Astragali, Radix cynanchi wilfordii, radix scrophulariae, radish seed, Chinese yam, the membrane of a chicken's gizzard, black sesame powder, radix cyathulae, Divine Comedy, donkey-hide gelatin, refined honey, pool
Rush down, peach kernel, rattletop, Fructus Aurantii, Radix Angelicae Sinensis, the mixing number of various composition is followed successively by：18~22 parts, 18~22 parts, 25~30 parts, 25
~30 parts, 12~15 parts, 18~22 parts, 8~12 parts, 12~15 parts, 12~15 parts, 8~12 parts, 12~15 parts, 8~12 parts,
45~50 parts, 18~22 parts, 8~12 parts, 8~12 parts, 8~12 parts, 8~12 parts.
Using said components, the preparation flow of traditional Chinese medicinal ointment of the present invention is described below, step is as follows：
(1) each self-watering of said components is continuously decocted three times, the number of the water added every time and the number phase of material
Together, the time and decocted for the first time is at least 3h, and second of the time decocted with third time is at least 1.5h；
(2) after decocting, all decocting liquids are mixed, and filtered, obtain filtrate；
(3) clear cream shape is concentrated the filtrate to, and adds donkey-hide gelatin and black sesame powder mixing, obtains secondary mixture；
(4) it is 1.25~1.30g/cm secondary mixture to be concentrated into density3Clear cream；
(5) add and refined honey and mix in clear cream, obtain traditional Chinese medicinal ointment, the portion rate of the clear cream and refined honey for 2: 1 (such as
100 parts of clear creams add 50 parts of refined honeys).
The present invention is oral drugs, a 10~20g, three times a day, is adapted to that yang deficiency of spleen and stomache constipation, constipation be postoperative, anus
The patients such as enteropathy is postoperative, elderly constipation, child's constipation take.
The effect of in order to embody the present invention, illustrated below with several treatment cases.
Case 1
River, female are 3 years old, medical on November 3rd, 2013.Patient engenders constipation after 1 years old, is 2~7 days defecations 1
Secondary, stool matter is stiff, cry and scream during defecation it is uneasy, exert and earn laborious, each feces volume is few, and feed poor, pale white complexion, body weight etc. is developed
Index children more of the same age are poor.Enema was given to receive anus once, the drug port such as probiotics, polyethylene glycol dissipate, lactulose oral solution
The treatment such as clothes, increase amount of drinking water, vegetables intake, has no obvious curative effects, examines and see pale white complexion, white and moist fur, weak pulse.It is dialectical to be：
The insufficiency of both the spleen and the kindey, suitable warm kidney strengthening the essence is controlled, is relaxed bowel.Using the present invention as healing potion, take day 3 times, each 10g, coordinate simultaneously
Enema receives anus.After treatment, daily defecation is unobstructed, and body weight substantially increases, and enema dosage gradually decreases after first quarter moon, after January not
With enema can voluntarily defecation, medication fully recover after 3 months, and being not required to just can voluntarily defecation by medicine.
Case 2
Xiong, female, 80 years old, retired cadre was medical on March 9th, 2014.Patient occurred just before 20 years without obvious inducement
It is secret, it is 2~3 days defecations 1 time, soft after stool is first stiff, defecation is laborious, voluntarily gives Maren wan oral medication, defecation leads to after medication
Freely.But occur repeatedly after being discontinued, the state of an illness gradually aggravates, normal 5~7 days defecations 1 time, and uncomfortable with abdominal distension, rectal tenesmus, feed subtracts
Few, mood agitation anxiety, sleep is poor, and defecation is more laborious, or even can not discharge, and need to have a strong impact on patient by enema treatment
Quality of life, examine and see pale white complexion, white and moist fur, weak pulse.It is dialectical to be：The insufficiency of both the spleen and the kindey, suitable warm kidney strengthening the essence is controlled, is relaxed bowel.With this
Invention is used as healing potion, takes day 3 times, each 20g, and non-defecation gives enema treatment within more than 3 days, basic 2 after taking medicine 1 month~
3 days defecations 1 time, 1~2 day defecation 1 time after medication 3 months, unobstructed, relative companion symptom disappears, and returns to normal life.
Case 3
Poplar, man, 45 years old, engineer was medical on November 10th, 2014.There is constipation before 10 years in patient, was examined in locality
Given extract oral treats (containing rheum officinale), and defecation is unobstructed after medication, occurs repeatedly after drug withdrawal.Voluntarily take afterwards and " moisten logical, Aloe Vera Gel
The purgatives such as capsule, Maren wan, cape jasmine golden flower balls " are treated, and are gradually formed purgatives dependence, aggravation before 3 years, are not arranged within most long 15 days
Just, oral purgatives positive effect weakens, and need to increase dose and coordinate bowel lavage to can be only achieved curative effect.(colon time is complete for underwent operative treatment
Resection and anastomosis art) after still have that defecation is laborious, the just symptom such as sense, rectal tenesmus discomfort not to the utmost, examine and see pale white complexion, white and moist fur, arteries and veins
It is weak.It is dialectical to be：The insufficiency of both the spleen and the kindey, suitable warm kidney strengthening the essence is controlled, is relaxed bowel.Using the present invention as healing potion, 3 times are taken day, every time
10g, above symptom disappears after taking medicine 1 month, returns to normal life.
Case 4
Zhang, female, 28 years old, guide was medical on December 5th, 2014.Patient was fat reducing clothes before 5 years with " slim tea, intestines are clear
The products such as tea ", suffered from diarrhoea after medication, engender constipation, to lack awareness of defecation, abdominal distension is uncomfortable, it is necessary to which oral diet products lead to
Just.Purgatives oral medications such as " rheum officinale are soaked, folium sennae, aloe capsule " is voluntarily given afterwards, is gradually formed purgatives dependence, is had a strong impact on
Patients ' life quality, examine and see pale white complexion, white and moist fur, weak pulse.It is dialectical to be：The insufficiency of both the spleen and the kindey, suitable warm kidney strengthening the essence is controlled, is relaxed bowel.
Using the present invention as healing potion, take day 3 times, each 20g, awareness of defecation, 2~3 days defecations 1 time, medication 3 occurs in medication after 1 month
1~2 day defecation 1 time, unobstructed after individual month, returns to normal life.
The present invention also has treatment yang deficiency of spleen and stomache constipation patient totally 678, as shown in the table：
The range of age of one, 678 yang deficiency of spleen and stomache constipation patient of table：
| Age (year) | 0-18 | 18-25 | 26-35 | 36-45 | 46-60 | More than 60 |
| Number of cases | 109 | 12 | 78 | 136 | 178 | 165 |
| Percentage | 16.1% | 1.8% | 11.5% | 20.0% | 26.3% | 24.3% |
The effect of two, 678 yang deficiency of spleen and stomache constipation patients of table table：
| Curative effect | Cure | Take a turn for the better | It is invalid |
| Number of cases | 668 | 10 | 0 |
| Percentage | 98.5% | 1.5% | Nothing |
The course for the treatment of table of three, 678 yang deficiency of spleen and stomache constipation patients of table：
| Treat number of days | January | The 1-2 months | The 2-3 months | It is more than March |
| Number of cases | 113 | 215 | 327 | 23 |
| Percentage | 16.7% | 31.7% | 48.2% | 3.4% |
Because substantial amounts of clinical empirical summary shows, the card type of most of chronic constipation is based on the insufficiency of both the spleen and the kindey, and gas
Anemia void is relatively conventional in constipation patient, therefore, present invention is generally directed to yang deficiency of spleen and stomache constipation, if it is simultaneous accompany the deficiency of vital energy,
Deficiency of blood person, then therapeutic effect is more preferably.
The present invention is improved to the Chinese medicine preparation for treating chronic constipation, and it achieves non-during practical application
The effect of often good.Using the present invention treat patients with chronic constipation, do not occur the toxic side effects such as Melanosis coli, pharmacological dependence and
Adverse reaction.Therefore, for compared to existing Chinese medicine preparation, present invention progress is fairly obvious, and it has prominent substance special
Point and significant progress.
Above-described embodiment is only the preferred embodiments of the present invention, is not construed as limiting the scope of the present invention, as long as adopting
With the design principle of the present invention, and the change for carrying out non-creativeness work on this basis and making, the present invention all should be belonged to
Protection domain within.
Claims (2)
1. a kind of traditional Chinese medicinal ointment for being used to treat chronic constipation, it is characterised in that by the following material composition of number：Saline cistanche 18~
22 parts, 18~22 parts of the bighead atractylodes rhizome, 25~30 parts of the Radix Astragali, 25~30 parts of Radix cynanchi wilfordii, 12~15 parts of radix scrophulariae, 18~22 parts of radish seed, mountain
8~12 parts of medicine, 12~15 parts of the membrane of a chicken's gizzard, 12~15 parts of black sesame powder, 8~12 parts of radix cyathulae, 12~15 parts of Divine Comedy, donkey-hide gelatin 8~
12 parts, 45~50 parts of refined honey, 18~22 parts of rhizoma alismatis, 8~12 parts of peach kernel, 8~12 parts of rattletop, 8~12 parts of Fructus Aurantii, Radix Angelicae Sinensis 8~12
Part, wherein, using saline cistanche as monarch drug in a prescription.
2. a kind of preparation method for being used to treat the traditional Chinese medicinal ointment of chronic constipation, it is characterised in that comprise the following steps：
(1) raw material is prepared：18~22 parts of saline cistanche, 18~22 parts of the bighead atractylodes rhizome, 25~30 parts of the Radix Astragali, 25~30 parts of Radix cynanchi wilfordii, radix scrophulariae
12~15 parts, 18~22 parts of radish seed, 8~12 parts of Chinese yam, 12~15 parts of the membrane of a chicken's gizzard, 12~15 parts of black sesame powder, radix cyathulae 8~
12 parts, 12~15 parts of Divine Comedy, 8~12 parts of donkey-hide gelatin, 45~50 parts of refined honey, 18~22 parts of rhizoma alismatis, 8~12 parts of peach kernel, rattletop 8~12
Part, 8~12 parts of Fructus Aurantii, 8~12 parts of Radix Angelicae Sinensis,
(2) saline cistanche, the bighead atractylodes rhizome, the Radix Astragali, Radix cynanchi wilfordii, radix scrophulariae, radish seed, Chinese yam, the membrane of a chicken's gizzard, radix cyathulae, Divine Comedy are each added
Water continuously decocts three times, and the number of the water added every time is identical with the number of material, and the time decocted for the first time is at least
3h, second of the time decocted with third time are at least 1.5h；
(3) after decocting, all decocting liquids in step (2) are mixed, and filtered, obtain filtrate；
(4) clear cream shape is concentrated the filtrate to, and adds donkey-hide gelatin and black sesame powder mixing, obtains secondary mixture；
(5) it is 1.25~1.30g/cm secondary mixture to be concentrated into density3Clear cream；
(6) add and refined honey and mix in clear cream, obtain traditional Chinese medicinal ointment, the portion rate of the clear cream and refined honey is 2: 1.
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