TW202019455A - Composition for tonifying kidney and strengthening Yang and preparation method and use thereof - Google Patents

Abstract

The invention relates to a composition for tonifying kidney and strengthening Yang. The composition is prepared from ginseng, radix astragali, coconut albumen and cistanche. Preferably, the weight ratio of the radix astragali to coconut albumen is 1: (0.1 to 10). The selected raw materials are safe to the human body and are environmentally friendly. Through combination of components, a synergistic effect is produced, the immunity is improved and effects of tonifying kidney and strengthening Yang, looseing bowel to relieve constipation and delaying aging are obtained.

Description

Composition for invigorating kidney and strengthening yang, preparation method and application thereof

The present invention relates to the field of functional foods, and in particular to a kidney and aphrodisiac composition.

With the improvement of people's material and cultural living standards, more and more people begin to pay attention to health, health care and beauty, etc., and they have recognized the serious side effects of chemical drugs and began to return to traditional Chinese medicine, especially the health level of men year by year There is a downward trend, and there are kidney deficiency, deficiency of qi and blood, decreased resistance, etc., which leads to many diseases, such as hair loss, dizziness, back pain, insomnia, and fever, as well as impotence, premature ejaculation, and prostate disease. Equal sex function declines. Western medicine circles often use glucocorticoids to treat kidney diseases, which relieves the patients' pain to a certain extent and improves the short-term efficacy. However, the uncontrolled use of hormones has caused patients to experience various irreversible serious symptoms.

With the change of people's diet structure and the influence of mental, psychological and social factors, the incidence of constipation tends to increase. The prevalence of constipation in the population is as high as 27%, which can affect people of all ages. Because constipation is a more common symptom, the symptoms vary, and most people often do not pay special attention to it, thinking that constipation is not a disease and does not need treatment, but in fact constipation is very harmful. Constipation plays an important role in the occurrence of certain diseases such as colon cancer, hepatic encephalopathy, breast disease, and Alzheimer's disease. There are many research reports in this regard; constipation can cause life accidents in patients with acute myocardial infarction and cerebrovascular accidents, and there are many pains Cases alert us; some constipation is closely related to anorectal diseases such as hemorrhoids and anal fissures.

The skin of young people should be fair and delicate, with rosy luster and full of elasticity. With age, the skin begins to age naturally. Together with the effects of spirit, nutrition, endocrine, drugs and ultraviolet radiation, it can accelerate the aging of the skin. It fades, the skin shrinks, the appearance of wrinkles and hyperpigmentation. There are many reasons for skin aging, but the main reason is that it is closely related to free radical damage to the skin. The aforementioned skin aging factors can generate a large amount of free radicals in the body, and through peroxidation, finally cause damage to cell tissue function and cell morphology and structure, manifested as skin degeneration, atrophy, roughness and dullness, and wrinkles and so on.

At present, there is an urgent need to develop a functional food that comprehensively and effectively improves immunity, nourishes the kidneys, relaxes the bowels, delays aging, and is safe.

The purpose of the present invention is to overcome the shortcomings of the conventional technology, and to provide a composition with a kidney and aphrodisiac effect. The composition provided by the invention combines and uses the components of ginseng, astragalus, coconut flesh, and cistanche, and can achieve the synergistic effect, and can effectively improve the immunity, aphrodisiac, kidney, laxative and laxative.

Specifically, the kidney and aphrodisiac composition provided by the present invention is prepared using raw materials including the following components: ginseng, astragalus, coconut flesh and cistanche.

The ginseng used in the present invention is the dried root of the ginseng of Araliaceae. The main component of ginseng is ginsenoside, which has the functions of eliminating free radicals in the body, anti-aging, anti-fatigue, enhancing memory, improving immunity, protecting the nervous system, protecting the myocardial system, anti-tumor cell proliferation and metastasis, and accelerating the growth of tumor cells. Decline and other effects.

The astragalus used in the present invention is the root of the leguminous plant Mongolian astragalus. Astragalus has the effects of invigorating qi and solidifying the surface, supporting poison and purging, diuresis, and muscular growth. It is used for qi deficiency and fatigue, prolapsed anal prolapse, spontaneous sweating, edema, prolapse of the child's official body, proteinuria in chronic nephritis, diabetes, and sores.

The coconut crumb used in the present invention is the endosperm of the palm family coconut. Coconut flesh has the effect of killing tapeworms. Drinking its juice and eating its flesh can repel insects.

The Cistanche deserticola used in the present invention is Cistanche deserticola, Cistanche deserticola, Cistanche deserticola and other fleshy stems. Cistanche has the effects of nourishing the kidney, improving essence, moisturizing, and smoothing the intestines. It can treat impotence in men, infertility in women, bring down, blood collapse, cold pain in the waist and knees, and constipation in blood dryness.

The raw materials selected in the present invention are all safe to the human body and friendly to the environment; the present invention progressively finds that the combined use of these ingredients can achieve a synergistic effect, which can effectively improve immunity, aphrodisiac and kidney , Laxative and laxative, delay aging. More importantly, although ginseng, astragalus, and cistanche are the classic matching methods in traditional Chinese medicine prescriptions, their shortcomings are easy to cause irritation, and for those with weak constitutions, the overdose formula will appear The situation of "compensating" cannot lead to good curative effect. The present invention has unexpectedly found that the introduction of the component of coconut flesh can improve the above defects. On the one hand, coconuts were born on the coast of the long tropical area, and they are the things in the sun, and take the meaning of seeking yin in the yin; on the other hand, the coconuts are stuffed into the lungs and spleen channels to take the effect of nourishing qi and strengthening the spleen, reconciling the greasiness in the formula. The tonicity of the tonic, alleviates the symptoms of tonic formation in the tonic, and improves the deficiency of tonic and not tonic. The overall formula regulates the overall function of the body from various angles such as laxative and laxative, and enhances immunity, and then achieves the effect of kidney and aphrodisiac. The present invention has found through a lot of practice that when the weight ratio of astragalus and coconut flakes is in the range of 1:0.1~1:10, each component can play the best synergistic effect.

As a preferred solution of the present invention, the composition is prepared by using raw materials including the following components in parts by weight: 1~10 servings of ginseng; 2-30 copies of astragalus; Coconut flakes 0.5~30 servings; and 1-15 Cistanche deserticola; Among them, the weight ratio of astragalus and coconut flesh is in the range of 1:0.1~1:10.

The composition provided by the present invention can be prepared by using only ginseng, astragalus, coconut flesh and cistanche as raw materials; at this time, in order to improve the synergy between the four components, the present invention is more preferably that of astragalus and coconut flesh The weight ratio is in the range of 1:5~1:10.

The composition provided by the present invention can also use other raw materials to assist ginseng, astragalus, coconut flesh and cistanche to exert the effect, and further achieve synergy, thereby adjusting the overall function of the body from multiple angles, and then achieving the effect of kidney and aphrodisiac. The other raw materials may be one or more of yam, wolfberry, poria, cinnamon, and licorice. After adding the above other raw materials, in order to improve the synergy between the components, the present invention further preferably has a weight ratio of astragalus and coconut flakes in the range of 1:0.1~1:1, more preferably 1:0.1 ~1: Within the range of 0.5.

The yam used in the present invention is the dried rhizome of the Dioscorea plant. Sweet and flat. Returning to the spleen, lung and kidney channels, it can regulate immunity, anti-oxidation, anti-aging, anti-tumor, and has a significant effect of lowering blood sugar. The preferred amount of yam in the composition of the present invention is 2-10 parts.

The wolfberry used in the present invention is the dried and ripe fruit of the nightshade plant Ningxia wolfberry. Wolfberry has the effects of enhancing immunity, anti-oxidation, lowering blood fat, lowering blood sugar, protecting the liver and delaying aging. Preferably, the amount of wolfberry in the composition of the present invention is 2-10 parts.

The Poria cocos used in the present invention is the dried sclerotia of Poria coccinea fungus Poria cocos, sweet, light, and calm, to the heart, lungs, spleen, and kidney meridian, which is beneficial to water infiltration, strengthening the spleen, and calming the heart. Poria has the functions of strengthening immunity, anti-tumor, anti-aging, lowering blood fat, protecting liver, diuretic, anti-inflammatory, and sleep aid. The preferred amount of Poria in the composition of the present invention is 1-10 parts.

The cinnamon used in the present invention is the dried bark of Cinnamomum camphora, which has a spicy, sweet, and hot sex, and belongs to the kidney, spleen, heart, and liver meridian. Cinnamon is clinically analgesic and antispasmodic, with antipyretic, hypoglycemic and blood pressure, antibacterial, antitumor, antiulcer and aphrodisiac effects. The preferred amount of cinnamon in the composition of the present invention is 0.5-5 parts.

The licorice used in the present invention is the dried roots and rhizomes of legume licorice, licorice bulge or licorice glabra, which has a sweet taste and a calm nature, and has heart, lung, spleen and stomach meridian. Licorice has anti-aging, anti-inflammatory, anti-viral, antihypertensive, enhancing body immunity, improving physiological functions, and inhibiting the growth of cancer cells. The preferred amount of licorice in the composition of the present invention is 1-10 parts.

In the present invention, the above five kinds of raw materials are preferably used together with ginseng, astragalus, coconut flesh and cistanche.

As a preferred solution of the present invention, the composition is prepared by using raw materials including the following components in parts by weight: 2~7 servings of ginseng; 6~12 servings of astragalus; Coconut flakes 1~9 servings; 4 to 11 servings of Cistanche deserticola; 2~10 servings of yam; 2-10 goji berries; Poria 1~10 servings; 0.5 to 5 servings of cinnamon; and 1~10 servings of licorice; Among them, the weight ratio of astragalus and coconut flesh is in the range of 1:0.1~1:10, preferably in the range of 1:0.1~1:1.

As a preferred solution of the present invention, the composition is prepared by using raw materials including the following parts by weight: 2~3 servings of ginseng; 9 to 11 servings of astragalus; Coconut flakes 1-2 servings; 9 to 11 servings of Cistanche; 5~7 servings of yam; 5~7 servings of wolfberry; Poria cocos 5~7 servings; 0.5 to 1.5 servings of cinnamon; and 2~4 servings of licorice; Wherein, the weight ratio of astragalus to coconut flesh is in the range of 1:0.1~1:0.5.

The composition provided by the present invention can be prepared according to conventional methods in the art. In order to further improve the kidney and aphrodisiac effect of the above composition, and to facilitate the preparation of products by mixing as an active ingredient and auxiliary materials, the composition of the present invention is preferably prepared by the following method: take each raw material, mix it with water, soak it thoroughly, and then cook it with a fire. , Ultrasonic extraction, the supernatant is separated, concentrated and dried, that is. The present invention has found through a lot of practice that the raw materials are decocted and ultrasonically extracted, and the resulting extract can enrich the effective ingredients in each raw material to the greatest extent, thereby ensuring that the effective ingredients can play a synergistic role.

The invention also protects the application of the composition in the preparation of foods or health products for kidney and aphrodisiac.

Specifically, the food or health care product for kidney and aphrodisiac provided by the present invention is prepared by using the composition as an effective ingredient and adding conventional auxiliary materials of food or health care products according to a conventional method in the art.

The invention also protects the application of the composition in the preparation of a medicine for preventing or treating constipation.

As a specific application mode, the medicine for preventing or treating constipation uses the composition as an active ingredient, and is added with conventional auxiliary materials of the medicine, and is prepared according to a conventional method in the art. The medicine is preferably an oral dosage form, such as common tablets, capsules, oral liquid, and the like. In order to facilitate the patient to take, and to play the role of laxative in the best pharmacokinetics, the present invention preferably said tablets are tablets.

Specifically, the present invention provides a tablet for kidney and aphrodisiac, and on the basis of the composition provided by the present invention, further includes a binder, a disintegrant, a lubricant, a flavoring agent, and a filler.

among them:

The binder may be selected from one or more of starch slurry, gelatin solution, sodium hydroxymethyl cellulose, and hydroxypropyl cellulose. In the raw material of the tablet, the amount of the binder is preferably 0.01 to 8 parts, more preferably 0.1 to 0.5 parts.

The disintegrant may be selected from one or more of dry starch, sodium hydroxymethyl starch, low-substituted hydroxypropyl cellulose sodium, and cross-linked hydroxymethyl cellulose sodium. In the raw material of the tablet, the amount of the disintegrant is preferably 0.01 to 3 parts, more preferably 0.5 to 1 part.

The lubricant may be selected from one or more of magnesium stearate, talc powder, micropowder silicone rubber, hydrogenated vegetable oil, and the like. In the raw material of the tablet, the amount of the lubricant is preferably 0.01 to 1.5 parts, more preferably 0.01 to 0.09 parts.

The flavoring agent may be selected from one or more of sodium saccharin, sucralose, cyclamate, stevioside, aspartame or stevioside. In the raw material of the tablet, the amount of the flavoring agent is preferably 0.01 to 1.5 parts, more preferably 0.1 to 0.5 parts.

The filler may be selected from one or more of starch, dextrin, mannitol, erythritol, and microcrystalline cellulose. In the raw material of the tablet, the amount of the filler is preferably 0.5 to 10 parts, more preferably 0.5 to 1 part.

As a specific embodiment of the present invention, the medicine uses the composition as an active ingredient, and further includes the following parts by weight of auxiliary materials: 0.01-8 parts of hydroxymethyl cellulose sodium; 0.01~3 servings of dry starch; 0.01~1.5 servings of magnesium stearate; 0.01 to 1.5 servings of saccharin sodium; and 0.5 to 10 servings of microcrystalline cellulose.

As a specific embodiment of the present invention, the medicine uses the composition as an active ingredient, and further includes the following parts by weight of auxiliary materials: 0.1~0.5 parts of sodium hydroxymethyl cellulose; 0.5~1 serving of dry starch; 0.01~0.09 parts of magnesium stearate; 0.1 to 0.5 servings of saccharin sodium; and 0.5 to 1 serving of microcrystalline cellulose.

The present invention also provides a method for preparing the above-mentioned medicine, which specifically includes the steps of: mixing the composition with a filler, a disintegrant, and a flavoring agent uniformly, then adding a binder to mix uniformly, drying, and granulating, and then adding a lubricant Mix well and press to make tablets.

The composition provided by the present invention uses traditional Chinese medicines such as ginseng, astragalus, coconut flesh, and cistanche as the raw materials. The above raw materials are safe for the human body and environmentally friendly; combining and using these components together can achieve a synergistic effect. Can effectively improve immunity, aphrodisiac, kidney, laxative, and delay aging.

The following examples are used to illustrate the present invention, but are not used to limit the scope of the present invention.

Example 1

This example provides a kidney and aphrodisiac composition prepared from the following raw materials: ginseng 10kg, astragalus 2kg, coconut flesh 18kg, and Cistanche deserticola 15kg.

The composition is prepared by the following method: each raw material is taken, mixed, fully immersed in water, simmered in water, and then subjected to ultrasonic extraction for 30 minutes, the supernatant is separated, concentrated, and spray-dried.

Example 2

This example provides a kidney and aphrodisiac composition. Compared with Example 1, the only difference is that the amount of each raw material is: 8kg of ginseng, 6kg of astragalus, 30kg of coconut flesh, and 1kg of Cistanche deserticola.

Example 3

This example provides a kidney and aphrodisiac composition. Compared with Example 1, the only difference is that the amount of each raw material is: 1kg of ginseng, 30kg of astragalus, 0.5kg of coconut flesh, and 13kg of Cistanche deserticola.

Example 4

This example provides a kidney and aphrodisiac composition. Compared with Example 1, the only difference is that it is prepared using the following raw materials: ginseng 7kg, astragalus 6kg, coconut flesh 3kg, cistanche 4kg, yam 10kg, wolfberry 2kg, Poria cocos 1kg, cinnamon 2kg, licorice 10kg.

Example 5

This example provides a kidney and aphrodisiac composition. Compared with Example 1, the only difference is that it is prepared from the following raw materials: ginseng 3kg, astragalus 12kg, coconut flesh 9kg, cistanche 11kg, yam 3kg, wolfberry 3kg, Poria 2kg, cinnamon 0.5kg, licorice 2kg.

Example 6

This example provides a kidney and aphrodisiac composition. Compared with Example 1, the only difference is that it is prepared from the following raw materials: ginseng 3kg, astragalus 7kg, coconut flesh 2kg, cistanche 5kg, yam 2kg, wolfberry 10kg, Poria cocos 10kg, cinnamon 5kg, licorice 1kg.

Example 7

This example provides a kidney and aphrodisiac composition. Compared with Example 1, the only difference is that it is prepared using the following raw materials: ginseng 2kg, astragalus 10kg, coconut flesh 1kg, cistanche 10kg, yam 6kg, wolfberry 6kg, Poria cocos 6kg, cinnamon 1kg, licorice 3kg.

Example 8

This example provides a tablet for invigorating the kidney and aphrodisiac, which uses the composition provided in Example 1 as an active ingredient, and further adds the following excipients: sodium hydroxymethyl cellulose 0.25 kg, dry starch 0.75 kg, and magnesium stearate 0.05 kg, saccharin sodium 0.25kg, microcrystalline cellulose 0.5kg.

The tablet is prepared by the following method: mixing the composition with dry starch, sodium saccharin and microcrystalline cellulose, and then adding sodium hydroxymethylcellulose, mixing evenly, after the wet granules are dried, the whole granules, Add magnesium stearate, mix well, and press to make tablets.

Example 9

This example provides a tablet for invigorating the kidney and aphrodisiac. Compared with Example 8, the only difference is that the composition provided in Example 2 is used as an active ingredient.

Example 10

This example provides a tablet for kidney and aphrodisiac. Compared with Example 8, the only difference is that the composition provided in Example 3 is used as an active ingredient.

Example 11

This example provides a tablet for kidney and aphrodisiac. Compared with Example 8, the only difference is that the composition provided in Example 4 is used as an active ingredient.

Example 12

This example provides a tablet for invigorating the kidney and aphrodisiac. Compared with Example 8, the only difference is that the composition provided in Example 5 is used as an active ingredient.

Example 13

This example provides a tablet for invigorating the kidney and aphrodisiac. Compared with Example 8, the only difference is that the composition provided in Example 6 is used as an active ingredient.

Example 14

This example provides a tablet for invigorating the kidney and aphrodisiac. Compared with Example 8, the only difference is that the composition provided in Example 7 is used as an active ingredient.

Comparative Example 1

This comparative example provides a tablet for invigorating the kidney and aphrodisiac. Compared with Example 8, the only difference is that no coconut flakes are used in the composition as an active ingredient.

Comparative Example 2

The present comparative example provides a tablet for invigorating the kidney and aphrodisiac. Compared with Example 8, the only difference is that in the composition as an active ingredient, coix seed is used instead of the coconut flesh.

Experimental Example 1

In this experimental example, the therapeutic effect of the tablets provided in the examples and comparative examples on constipation was tested.

Select 40 patients in each group who were diagnosed with constipation. The test subjects met the following criteria: ① The course of constipation was greater than 6 months, with symptom onset in the last 3 months; ② Those older than 16 years old and less than 80 years old; ③ The patients signed an informed consent and voluntarily participated in the study.

Each patient takes the medicine once a day, 0.033g/kg each time.

Constipation clinical score: ① voluntary defecation: yes (0 points), defecation with the aid of drugs, hand-assisted or enema (3 points); ② sense of constipation: yes (0 points), no (1 point); ③ self-defecation frequency: 1~ One bowel movement on the 2nd (0 points), one bowel movement on the 3rd to 4th days (1 point), one bowel movement on the 5th to 6th days (2 points), and one bowel movement on the 6th or more days (3 points), you cannot defecate yourself (4 points); ④ Defecation effort level: natural defecation, no defecation effort (0 points), defecation effort (1 point), hard work to defecation (2 points); ⑤ time for each bowel movement: 1~10 min (0 points), 11~ 20 min (1 point), 21~30 min (2 points), more than 30 min (3 points); ⑥ Feces: hard blocks scattered (3 points), hard blocks into strips (2 points), showing cracks (1 point) ), into a strip of light and soft (0 points); ⑦ abdominal distension, abdominal pain, endless bowel sensation, anal bloating, anal obstruction, poor exhaust feeling 6 symptoms are none (0 points), mild (1 point) ), obviously (2 points), unbearable (3 points) 4 grades.

Efficacy evaluation standard "Guiding Principles of Clinical Research on New Drugs of Traditional Chinese Medicine", combined with the clinical, self-made the following evaluation criteria for the efficacy of the main symptoms: ① clinical recovery: the main symptoms disappear, normal bowel movements, and the clinical symptom score of constipation is 0; ② marked effect: the clinical symptoms have improved significantly , Clinical symptom score decreased by ≥2/3 compared with before treatment; ③ Effective: Clinical symptoms improved, but clinical symptom score decreased by 1/2~2/3; ④ Improved: Clinical symptoms improved, but clinical symptom score decreased than before treatment ≤ 1/2; ⑤ Ineffective: No improvement or aggravation of clinical symptoms, and no decrease or increase of clinical symptom scores.

The treatment results are shown in Table 1.

註：總有效率=（臨床痊癒+顯效+有效+好轉）/每組總例數×100%Table 1: Treatment effect of constipation

Note: total effective rate = (clinical recovery + marked effect + effective + improvement) / total number of cases per group × 100%

Experimental Example 2

This experimental example verified the effect of the tablets provided in Examples 9, 13, and 14 on kidney and aphrodisiac.

Eighty Kunming male rats weighing 18-22g, each group of 10 rats, were randomly divided into 6 groups: normal control group, model control group, positive control group, comparative example 1, comparative example 2, example 9, example 13 、实施例14。 Example 14.

Except for the normal control group, each group was intraperitoneally injected with hydrocortisone 25mg·kg ^-1 to prepare a kidney-yang deficiency model. The positive control group was injected subcutaneously with a testosterone propionate solution 2 mg·kg ^-1 , and the rest was dosed. Continuous administration for 7 days, daily administration of 33 mg kg ^-1 , 1 hour after the last administration, the stimulation electrode of the physiological pharmacological electronic stimulator was applied to the penis of the mouse, the current intensity was 0.2 mA, and the voltage was 150 mV, recording from the start of stimulation to the penis The erection time (erection incubation period), the results are shown in Table 2.

Table 2: Effect of composition on the penile erection latency of mice

The mice were sacrificed 24 hours after the last administration, the prostate + seminal vesicles, testes, and foreskin were removed, and the connective tissues such as surrounding fat were separated. Weigh the prostate + seminal vesicles, testes and prepuce glands immediately. The results are shown in Table 3.

Table 3: Effect of composition on mouse sex organs (mg/kg.bw)

Experimental Example 3

This experimental example verifies the immunity-enhancing effect of the tablet provided in Example 14.

180 Kunming mice were selected, weighing 18-22g, and randomly divided into 3 groups, with each group consisting of 4 groups and 10 mice in each group: normal control group, comparative example 1 (33mg ▪ kg ^-1 ), comparative example 2 (33mg▪kg ^-1), Example 14 provides a low-dose tablet (specifically dose 33mg▪kg ^-1), medium dose group (provided that the specific dose tablet of Example 14 embodiment 66mg▪kg ^{- 1} ). In the high-dose group of tablets provided in Example 14 (the specific dose is 165 mg·kg ^-1 ), mice are gavaged, and the control group is gavaged with an equal volume of distilled water, once a day, measured after 30 days of continuous administration The following indicators. The results of ConA-induced splenic lymphocyte transformation in mice are shown in Table 4, the results of delayed-type hyperactivity in mice are shown in Table 5, and the measurement results of NK cell activity are shown in Table 6.

註：與空白組對比^* P＜0.05Table 4: ConA-induced mouse spleen lymphocyte transformation experiment

Note: Compared with the blank group ^* P＜0.05

註：與空白組對比^△ P＜0.05Table 5: Late-onset reaction in mice

Note: Compared with the blank group ^△ P＜0.05

註：與空白組對比^★ P＜0.05Table 6: Determination of NK cell activity (x(1)±s)

Note: Compared with the blank group ^★ P＜0.05

It can be seen from Table 4, Table 5 and Table 6 that compared with the blank group, the three groups of low, medium and high doses can significantly improve the lymphocyte proliferation ability, foot and plantar swelling and NK cell activity of normal mice. This shows that the composition has the effects of improving the immunity of the body and the disease resistance of the body.

Experimental Example 5

This experimental example verified the anti-aging effect of the tablet provided in Example 14.

70 Kunming mice, weighing 18-22g, were randomly divided into 5 groups of 10 mice each: normal control group, comparative example 1 (33mg ▪ kg ^-1 ), comparative example 2 (33mg ▪ kg ^-1 ) , Low-dose group (specific dose is 33mg kg ^-1 ), medium-dose group (specific dose 66mg ▪ kg ^-1 ), high-dose group (specific dose 165mg ▪ kg ^-1 ). Except for the blank control group, the other groups were injected with 0.5 mL of 5% D-galactose solution under the neck every day. The control group was given an equal volume of normal saline once a day. After 30 days of continuous administration of the test substance to mice, serum, liver, and brain were measured. The results of tissue malondialdehyde (MDA) content and superoxide dismutase (SOD) activity are shown in Table 7 and Table 8.

Table 7: Effect on MDA content in mice

Table 8: Effect on SOD activity in mice

From the above results, it can be seen that the composition of the present invention can reduce the content of MDA in serum, liver, and brain tissue, can increase the SOD activity in serum, liver, and brain tissue, and achieve the effect of delaying aging.

Although the present invention has been described in detail with general descriptions, specific embodiments and experiments, but on the basis of the present invention, some modifications or improvements can be made to it, which is for those with ordinary knowledge in the field It is obvious. Therefore, these modifications or improvements made on the basis of not deviating from the spirit of the present invention are within the scope of the claimed invention.

no.

no.

no.

Claims (10)

A kidney and aphrodisiac composition is prepared from raw materials including the following components: ginseng, astragalus, coconut flesh and cistanche. The composition as described in item 1 of the patent application scope is prepared by using raw materials including the following components in parts by weight: 1~10 servings of ginseng; 2-30 copies of astragalus; Coconut flakes 0.5~30 servings; and 1-15 Cistanche deserticola; Among them, the weight ratio of astragalus and coconut flesh is in the range of 1:0.1~1:10. The composition according to any one of items 1 to 2 of the patent application range, wherein the raw material further includes one or more of yam, wolfberry, poria, cinnamon, and licorice. The composition as described in item 3 of the patent application scope is further prepared by using raw materials including the following components in parts by weight: 2~7 servings of ginseng; 6~12 servings of astragalus; Coconut flakes 1~9 servings; 4 to 11 servings of Cistanche deserticola; 2~10 servings of yam; 2-10 goji berries; Poria 1~10 servings; 0.5 to 5 servings of cinnamon; and 1~10 servings of licorice; Among them, the weight ratio of astragalus and coconut flesh is in the range of 1:0.1~1:10. The composition as described in item 3 of the patent application scope is further prepared by using raw materials including the following components in parts by weight: 2~3 servings of ginseng; 9 to 11 servings of astragalus; Coconut flakes 1-2 servings; 9 to 11 servings of Cistanche; 5~7 servings of yam; 5~7 servings of wolfberry; Poria cocos 5~7 servings; 0.5 to 1.5 servings of cinnamon; and 2~4 servings of licorice; Among them, the weight ratio of astragalus and coconut flesh is in the range of 1:0.1~1:0.5. A method for preparing a composition as described in any one of claims 1 to 5 includes the following steps: taking each raw material, mixing it, soaking it in water, simmering, sonicating and separating The supernatant, concentrated and dried, is available. An application of the composition as described in any one of patent application items 1 to 5 in the preparation of foods, health products or medicines for kidney and aphrodisiac. A medicine for preventing and treating constipation, which is prepared by using the composition as described in any one of patent application items 1 to 5 as an active ingredient, and then adding auxiliary materials; The auxiliary materials include binders, disintegrants, lubricants, flavoring agents and fillers; among them: The binder is selected from one or more of starch slurry, gelatin solution, sodium hydroxymethyl cellulose and hydroxypropyl cellulose; The disintegrant is selected from one or more of dry starch, sodium hydroxymethyl starch, low-substituted hydroxypropyl cellulose sodium, and cross-linked hydroxymethyl cellulose sodium; The lubricant is selected from one or more of magnesium stearate, talc powder, micropowder silicone rubber, hydrogenated vegetable oil; The flavoring agent is selected from one or more of saccharin sodium, sucralose, cyclamate, stevioside, aspartame or stevioside; The filler is selected from one or more of starch, dextrin, mannitol, erythritol, and microcrystalline cellulose. The medicament as described in item 8 of the patent application, which uses the composition as described in any one of patent application items 1 to 5 as an active ingredient, further includes the following parts by weight of auxiliary materials: 0.01~8 copies of adhesive; 0.01~3 parts of disintegrant; 0.01~1.5 parts of lubricant; 0.01 to 1.5 servings of flavoring agent; and Filler 0.5~10 parts. A method for preparing a medicine as described in item 8 or 9 of the patent application, which includes the steps of: mixing the composition with the filler, the disintegrant, and the flavoring agent uniformly, and then adding the adhesive The agent is mixed evenly, after drying, the whole grain is added, and then the lubricant is added to mix evenly and tabletted.