CN105250571A - Spray preparation for treating liver and gall fire exuberance type acute suppurative otitis media - Google Patents
Spray preparation for treating liver and gall fire exuberance type acute suppurative otitis media Download PDFInfo
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Abstract
The invention discloses a spray preparation for treating liver and gall fire exuberance type acute suppurative otitis media. The spray preparation is prepared from burdock, radix bupleuri, scutellaria baicalensis, dandelion, rhizoma acori graminei, Japanese xylosma roots, selfheal, chrysanthemum, water chestnuts, mung beans, akebiaquinata, periostracum cicada, daphne genkwa and herba orostachyos. The spray preparation has the advantages that the purposes of clearing liver fire and removing toxicity for detumescence serve as the main treatment principle, and the effects of promoting blood circulation to remove the blood stasis, eliminating stagnation, expelling carbuncle, cleaning heat, expelling wind, purging fire, excreting water and promoting blood circulation are simultaneously achieved; the spray preparation mainly treats the liver and gall fire exuberance type acute suppurative otitis media, is a novel drug which is simple in preparation technology, few in toxic and side effects, convenient to administrate, easy to prepare and low in cost and can directly act on a lesion, the curing time is short, and the liver and gall fire exuberance type acute suppurative otitis media is not prone to relapsing after being cured.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of spray for the treatment of the anxious glue ear of liver and gall fire Sheng type.
Background technology
Anxious glue ear refers to that onset is comparatively anxious, and ear's pain, tympanic member perforation, purulent ear is the disease of main manifestations.Be equivalent to the acute suppurative otitis media of doctor trained in Western medicine.Anxious glue ear is commonly encountered diseases, frequently-occurring disease, is especially mainly in children's.Primary disease can be sent out any season, and being summer many.
At the anxious glue ear initial stage, before the perforation of ear drum, General Symptoms is obvious, and otalgia is violent, and in ear deep sharp pain, pulsation jumping pain, pain can be radiated to homonymy head.Whole body can with fever with aversion to cold, high heat can be there is, twitch, cry and scream in children's, refusing to eat, vomiting, diarrhoea etc.After the perforation of ear drum, pus outflows, and febrile lysis, otalgia alleviate, and General Symptoms fades mistake.
Check: before the perforation of ear drum, tympanum is that diffusivity is congested, very then outside bulge, and audition obviously goes down, in transmission deafness.After the perforation of ear drum, pus outflows, and external auditory meatus is shown in purulence or septic secretions, wipes dope off, visible tympanum has the reflective bright spot of a pollex, and pus flows out from this pulsation.
Anxious glue ear should be differentiated mutually with furuncle of external auditory meatus, inflammation of external auditory meatus.Furuncle of external auditory meatus, inflammation of external auditory meatus person, auditory meatus can have pus, but tympanum is without perforation, can provide discriminating.
Current anxious glue ear is divided into wind heat damp type and two kinds, liver and gall fire Sheng type, and wherein: the invasion and attack of wind heat damp are the main exopathogenic factors of anxious glue ear, and patient's ferritic liver and gall have heat to be the common endogenous cause of ill of anxious glue ear.Because baby nursing method is improper, cold nasal obstruction or to exert oneself blowing the nose when suffering from cacorhinia, pleasant or tympanum wound of sewage etc., and cause outside wind heat damp and attack ear key, accumulate burning hot in priming, inside and outside pathogenic heat knot and falling ill.Pathogenic heat tired knot ear key, steams the tympanum that burns, qi depression to blood stasis, disorder of QI movement, therefore in ear pain, pathogenic heat Sheng person, sharp ache.Burning hot evil poison steams and burns, and putrefaction of blood and muscle, then purulent ear Huang is thick.Total Therapeutic Method is that purging liver and gallbladder is damp and hot.
In the prior art, the anxious glue ear of western medical treatment, the course for the treatment of is longer, widely applies antibiotic for a long time, easily produces drug resistance, and especially to child patient, clinical efficacy is not satisfactory, and the easy recurrent exerbation of the state of an illness, has a strong impact on the quality of life etc. of patient.
But the anxious glue ear of Chinese medicine, possesses unique advantage and feature: utilize Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to the treatment of different disease Mutiple Targets, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and not easily produces that drug resistance, cost price are lower, convenient drug administration, patient is easy to accept, can cure rate be significantly improved, reduce complication, reduce relapse rate, significantly improve the quality of life etc. of patient.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of spray for the treatment of the anxious glue ear of liver and gall fire Sheng type, and the processing technology of tool of the present invention is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost, focus of going directly, healing time is short, not easily recurs after healing.
In order to realize foregoing invention object, the invention provides a kind of spray for the treatment of the anxious glue ear of liver and gall fire Sheng type, wherein, following raw medicinal material is comprised: Fructus Arctii, Radix Bupleuri, Radix Scutellariae, Herba Taraxaci, Rhizoma Acori Graminei, Radix Xylosmae japonici, Spica Prunellae, Flos Chrysanthemi, Corm Eleocharitis, Semen phaseoli radiati, Caulis Akebiae, Periostracum Cicadae, Flos Genkwa, Herba Orostachyos.
In described spray, the ratio of weight and number of each raw medicinal material is: Fructus Arctii 10-30 part, Radix Bupleuri 15-35 part, Radix Scutellariae 8-26 part, Herba Taraxaci 12-40 part, Rhizoma Acori Graminei 5-32 part, Radix Xylosmae japonici 10-30 part, Spica Prunellae 15-40 part, Flos Chrysanthemi 10-35 part, Corm Eleocharitis 5-30 part, Semen phaseoli radiati 5-20 part, Caulis Akebiae 20-40 part, Periostracum Cicadae 12-30 part, Flos Genkwa 8-26 part, Herba Orostachyos 10-30 part.
Further, in described spray, the ratio of weight and number of each raw medicinal material is: Fructus Arctii 15-25 part, Radix Bupleuri 18-30 part, Radix Scutellariae 10-22 part, Herba Taraxaci 15-30 part, Rhizoma Acori Graminei 10-25 part, Radix Xylosmae japonici 15-25 part, Spica Prunellae 20-30 part, Flos Chrysanthemi 15-30 part, Corm Eleocharitis 10-20 part, Semen phaseoli radiati 10-18 part, Caulis Akebiae 25-35 part, Periostracum Cicadae 15-25 part, Flos Genkwa 10-20 part, Herba Orostachyos 15-25 part.
Further, in described spray, the ratio of weight and number of each raw medicinal material is: Fructus Arctii 20 parts, Radix Bupleuri 20 parts, Radix Scutellariae 15 parts, Herba Taraxaci 20 parts, Rhizoma Acori Graminei 15 parts, Radix Xylosmae japonici 20 parts, Spica Prunellae 25 parts, Flos Chrysanthemi 20 parts, Corm Eleocharitis 15 parts, 15 parts, Semen phaseoli radiati, Caulis Akebiae 30 parts, Periostracum Cicadae 20 parts, Flos Genkwa 15 parts, Herba Orostachyos 20 parts.
The dosage form of described medicine is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture weight 1.5-2 obtained water soaking 6-15 hour doubly, after intense fire boils, use slow fire instead and decoct 25 minutes slowly, repeat decoction after truce again 2 times, merge three decoction liquor, filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 2 hours, extract twice, each extraction 2.5 hours, merge extractive liquid, 200 orders filter, get 5000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 8000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 75 DEG C 1.20;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
The anxious glue ear for the treatment of liver and gall fire Sheng type, with clearing away liver-fire, removing toxic substances and promoting subsidence of swelling for primary treatment principle, should hold concurrently with promoting blood circulation to remove blood stasis, eliminating stagnation eliminating carbuncle, cleaning heat and expelling wind, pathogenic fire purging row water, promoting blood circulation; Based on this, the pharmacology of above-mentioned raw materials medical material is as follows:
Fructus Arctii: nature and flavor bitter, acrid, cold.Heat-clearing and toxic substances removing, dispelling wind sore-throat relieving.For anemopyretic cold, cough, laryngopharynx swelling and pain, furuncle swells and ache, tinea pedis, eczema.
Radix Bupleuri: nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Radix Scutellariae: nature and flavor are bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Herba Taraxaci: nature and flavor are bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
Radix Xylosmae japonici: nature and flavor are bitter; Property is put down.Return liver; Spleen channel.Removing toxic substances; Dampness removing; Dissipating blood stasis; Hasten parturition.Main jaundice; Dysentery; Edema; Lung core is spat blood; Scrofula; Treating swelling and pain by traumatic injury; Difficult labour; Retention of dead fetus.
Spica Prunellae: nature and flavor are bitter; Pungent; Cold in nature.Return liver; Gallbladder meridian.Liver heat removing and eyesight improving; Powder detoxifcation.Argument is photophobia also; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute hepatitis, chronic hepatitis; Hypertension.
Flos Chrysanthemi: nature and flavor sweetness and bitterness is cool.Be included into lung, Liver Channel.Dispelling wind, heat clearing away, improving eyesight, removing toxic substances.Control headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.
Corm Eleocharitis: nature and flavor are sweet, flat.Relieve heat and thirst, dampness removing reduces phlegm, blood pressure lowering.For consumption of body fluid caused by febrile disease excessive thirst, laryngopharynx swelling and pain, stomatitis, jaundice due to damp-heat, hypertension, dysuria, measles, cough due to lung-heat, silicosis, bleeding hemorrhoids.
Semen phaseoli radiati: nature and flavor are sweet, cold.Be included into the heart, stomach warp.Heat-clearing and toxic substances removing, relieves summer heat.For summer-heat excessive thirst, the diseases such as sore carbuncle.Radix Aconiti Lateralis Preparata, Fructus Crotonis poison can be separated.
Caulis Akebiae: nature and flavor are bitter, cool.Be included into the heart, small intestinal, urinary bladder channel.Pathogenic fire purging row water, promoting blood circulation.Control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.
Periostracum Cicadae: property sweet-salty is cool.Be included into lung, Liver Channel.Loose wind heat, lung qi dispersing, determines convulsion.Control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, rubella pruritus, pediatric epilepsy scared, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.
Flos Genkwa: nature and flavor are pungent; Bitter; Warm in nature; Poisonous.Return lung; Spleen; Kidney; Urinary bladder channel.Removing fluid-retention by purgation; Expelling phlegm for arresting cough; Removing toxic substances parasite killing.Main edema; Expand; Phlegm retention breast water; Breath with cough; Carbuncle furuncle tinea.
Herba Orostachyos: nature and flavor are bitter is cool, poisonous.Be included into liver, lung two warp.Heat-clearing and toxic substances removing, hemostasis, dampness removing, detumescence.Control haematemesis, epistaxis, dysentery, hepatitis, malaria, pyretic stranguria, hemorrhoid, eczema, carbuncle poison, furuncle, soup fire is burnt.
The beneficial effect that technical scheme provided by the invention is brought is: the present invention has clearing away liver-fire, removing toxic substances and promoting subsidence of swelling is primary treatment principle, holds concurrently with promoting blood circulation to remove blood stasis, eliminating stagnation eliminating carbuncle, cleaning heat and expelling wind, pathogenic fire purging row water, promoting blood circulation, cures mainly the anxious glue ear of liver and gall fire Sheng type; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, and new drug with low cost, focus of going directly, healing time is short, not easily recurs after healing.
Detailed description of the invention
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
A kind of spray for the treatment of the anxious glue ear of liver and gall fire Sheng type provided by the invention, comprises following raw medicinal material: Fructus Arctii, Radix Bupleuri, Radix Scutellariae, Herba Taraxaci, Rhizoma Acori Graminei, Radix Xylosmae japonici, Spica Prunellae, Flos Chrysanthemi, Corm Eleocharitis, Semen phaseoli radiati, Caulis Akebiae, Periostracum Cicadae, Flos Genkwa, Herba Orostachyos.
Its concrete ingredient and preparation process are as described in the following Examples.
Embodiment one:
Each medical material weight ratio of spray of the present invention is: Fructus Arctii 10 parts, Radix Bupleuri 15 parts, Radix Scutellariae 8 parts, Herba Taraxaci 12 parts, Rhizoma Acori Graminei 5 parts, Radix Xylosmae japonici 10 parts, Spica Prunellae 15 parts, Flos Chrysanthemi 10 parts, Corm Eleocharitis 5 parts, 5 parts, Semen phaseoli radiati, Caulis Akebiae 20 parts, Periostracum Cicadae 12 parts, Flos Genkwa 8 parts, Herba Orostachyos 10 parts.
Its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture weight 1.5-2 obtained water soaking 6-15 hour doubly, after intense fire boils, use slow fire instead and decoct 25 minutes slowly, repeat decoction after truce again 2 times, merge three decoction liquor, filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 2 hours, extract twice, each extraction 2.5 hours, merge extractive liquid, 200 orders filter, get 5000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 8000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 75 DEG C 1.20;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
Embodiment two:
Each medical material weight ratio of spray of the present invention is: Fructus Arctii 30 parts, Radix Bupleuri 35 parts, Radix Scutellariae 26 parts, Herba Taraxaci 40 parts, Rhizoma Acori Graminei 32 parts, Radix Xylosmae japonici 30 parts, Spica Prunellae 40 parts, Flos Chrysanthemi 35 parts, Corm Eleocharitis 30 parts, 20 parts, Semen phaseoli radiati, Caulis Akebiae 40 parts, Periostracum Cicadae 30 parts, Flos Genkwa 26 parts, Herba Orostachyos 30 parts.
Its preparation process is with embodiment one.
Embodiment three:
Each medical material weight ratio of spray of the present invention is: Fructus Arctii 15 parts, Radix Bupleuri 18 parts, Radix Scutellariae 10 parts, Herba Taraxaci 15 parts, Rhizoma Acori Graminei 10 parts, Radix Xylosmae japonici 15 parts, Spica Prunellae 20 parts, Flos Chrysanthemi 15 parts, Corm Eleocharitis 10 parts, 10 parts, Semen phaseoli radiati, Caulis Akebiae 25 parts, Periostracum Cicadae 15 parts, Flos Genkwa 10 parts, Herba Orostachyos 15 parts.
Its preparation process is with embodiment one.
Embodiment four:
Each medical material weight ratio of spray of the present invention is: Fructus Arctii 25 parts, Radix Bupleuri 30 parts, Radix Scutellariae 22 parts, Herba Taraxaci 30 parts, Rhizoma Acori Graminei 25 parts, Radix Xylosmae japonici 25 parts, Spica Prunellae 30 parts, Flos Chrysanthemi 30 parts, Corm Eleocharitis 20 parts, 18 parts, Semen phaseoli radiati, Caulis Akebiae 35 parts, Periostracum Cicadae 25 parts, Flos Genkwa 20 parts, Herba Orostachyos 25 parts.
Its preparation process is with embodiment one.
Embodiment five:
Each medical material weight ratio of spray of the present invention is:: Fructus Arctii 20 parts, Radix Bupleuri 20 parts, Radix Scutellariae 15 parts, Herba Taraxaci 20 parts, Rhizoma Acori Graminei 15 parts, Radix Xylosmae japonici 20 parts, Spica Prunellae 25 parts, Flos Chrysanthemi 20 parts, Corm Eleocharitis 15 parts, 15 parts, Semen phaseoli radiati, Caulis Akebiae 30 parts, Periostracum Cicadae 20 parts, Flos Genkwa 15 parts, Herba Orostachyos 20 parts.
Its preparation process is with embodiment one.
In use, every day uses 4-8 time spray of the present invention, at every turn to affected part spray 3-10 time, i.e. and 10-15ml.
Clinical data:
Patient normal certain, female, 3 years old, in October, 2012 went to a doctor.Time ill, ear's pain is strong, and whole body has low grade fever symptom, and occurs deaf situation, and ear flows out with pus, is diagnosed as the anxious glue ear of liver and gall fire Sheng type after perforation of ear drum inspection.Use the spray of invention formulation, every day 4 times, spray 3s at every turn, amount to about 12ml, after 2 days, ear's pain symptom obviously alleviates, basic disappearance after a week.Continue use recovery from illness after a week, follow up a case by regular visits to so far without recurrence.
The advantage be proven, spray provided by the invention has that effective percentage is high, determined curative effect, safety are high, having no side effect; Clinical treatment 86 example so far from 2008, result is fully recovered 82 examples (accounting for 95%), 4 examples that take a turn for the better (accounting for 5%), invalid 0 example.Total effective rate is 100%.The course for the treatment of, most elder was 22 days, and the shortest person is 2 days, generally at about 10 days.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. treat the spray of the anxious glue ear of liver and gall fire Sheng type for one kind, it is characterized in that, at least include but not limited to following raw medicinal material: Fructus Arctii, Radix Bupleuri, Radix Scutellariae, Herba Taraxaci, Rhizoma Acori Graminei, Radix Xylosmae japonici, Spica Prunellae, Flos Chrysanthemi, Corm Eleocharitis, Semen phaseoli radiati, Caulis Akebiae, Periostracum Cicadae, Flos Genkwa, Herba Orostachyos.
2. spray according to claim 1, it is characterized in that, the ratio of weight and number of described each raw medicinal material is: Fructus Arctii 10-30 part, Radix Bupleuri 15-35 part, Radix Scutellariae 8-26 part, Herba Taraxaci 12-40 part, Rhizoma Acori Graminei 5-32 part, Radix Xylosmae japonici 10-30 part, Spica Prunellae 15-40 part, Flos Chrysanthemi 10-35 part, Corm Eleocharitis 5-30 part, Semen phaseoli radiati 5-20 part, Caulis Akebiae 20-40 part, Periostracum Cicadae 12-30 part, Flos Genkwa 8-26 part, Herba Orostachyos 10-30 part.
3. spray according to claim 1 and 2, it is characterized in that, the ratio of weight and number of described each raw medicinal material is: Fructus Arctii 15-25 part, Radix Bupleuri 18-30 part, Radix Scutellariae 10-22 part, Herba Taraxaci 15-30 part, Rhizoma Acori Graminei 10-25 part, Radix Xylosmae japonici 15-25 part, Spica Prunellae 20-30 part, Flos Chrysanthemi 15-30 part, Corm Eleocharitis 10-20 part, Semen phaseoli radiati 10-18 part, Caulis Akebiae 25-35 part, Periostracum Cicadae 15-25 part, Flos Genkwa 10-20 part, Herba Orostachyos 15-25 part.
4. according to the arbitrary described spray of claim 1-3, it is characterized in that, the ratio of weight and number of described each raw medicinal material is: Fructus Arctii 20 parts, Radix Bupleuri 20 parts, Radix Scutellariae 15 parts, Herba Taraxaci 20 parts, Rhizoma Acori Graminei 15 parts, Radix Xylosmae japonici 20 parts, Spica Prunellae 25 parts, Flos Chrysanthemi 20 parts, Corm Eleocharitis 15 parts, 15 parts, Semen phaseoli radiati, Caulis Akebiae 30 parts, Periostracum Cicadae 20 parts, Flos Genkwa 15 parts, Herba Orostachyos 20 parts.
5., according to the arbitrary described spray of claim 1-4, it is characterized in that, the dosage form of described medicine is spray, and its preparation process comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture weight 1.5-2 obtained water soaking 6-15 hour doubly, after intense fire boils, use slow fire instead and decoct 25 minutes slowly, repeat decoction after truce again 2 times, merge three decoction liquor, filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 2 hours, extract twice, each extraction 2.5 hours, merge extractive liquid, 200 orders filter, get 5000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 8000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 75 DEG C 1.20;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
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| CN112294865A (en) * | 2020-11-30 | 2021-02-02 | 黑龙江中医药大学 | Traditional Chinese medicine preparation for treating suppurative otitis media and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104873778A (en) * | 2015-06-02 | 2015-09-02 | 岳兵兵 | Otitis media treatment drops and preparation method |
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| CN104873778A (en) * | 2015-06-02 | 2015-09-02 | 岳兵兵 | Otitis media treatment drops and preparation method |
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| 张卫红 等: "《临床危重病学》", 31 July 2008 * |
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| CN112294865A (en) * | 2020-11-30 | 2021-02-02 | 黑龙江中医药大学 | Traditional Chinese medicine preparation for treating suppurative otitis media and preparation method thereof |
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Application publication date: 20160120 |