CN104189335A - Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof - Google Patents
Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof Download PDFInfo
- Publication number
- CN104189335A CN104189335A CN201410443306.4A CN201410443306A CN104189335A CN 104189335 A CN104189335 A CN 104189335A CN 201410443306 A CN201410443306 A CN 201410443306A CN 104189335 A CN104189335 A CN 104189335A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- flos
- lacrimal passage
- dacryocystisis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses lacrimal passage flushing fluid for caring infantile dacryocystitis and a preparation method thereof. The lacrimal passage flushing fluid for caring infantile dacryocystitis is prepared from the following medicinal materials in proportion: ramose scouring rush herb, Chinese pearleaf crabapple leaf, senecio scandens, lysimachia christinae hance, phyllanthus ruinaria, felwort, pipewort, dragon's blood, rheum officinale, gallnuts, honeysuckle, wild chrysanthemum flower, butterflybush flower, dandelion, safflower, rosemary and lavender, and pure medicine liquid is prepared from active ingredients extracted from all the medicinal materials. The lacrimal passage flushing fluid for caring infantile dacryocystitis disclosed by the invention can promote emptying of secretions out of lacrimal sacs, thoroughly remove purulent or mucinous secretions and enhance curative effect of medicine; in addition, the flushing fluid also solves a problem of existing lacrimal passage flushing fluid which is irritant to eyes; the flushing fluid disclosed by the invention is safe and non-irritant and is capable of assisting treatment of dacryocystitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of children's's dacryocystisis nursing irrigation of lacrimal passage liquid and preparation method thereof.
Background technology
Neonatal dacryocystitis is because the residual film of embryo of nasolacrimal duct lower end is not degenerated, and blocks nasolacrimal duct lower end, and tear and antibacterial retention, in lachrymal sac, cause due to secondary infection.Neonatal dacryocystitis is more common oculopathy, and the eyes that show as baby can be often tearful.In baby's eyes, have many dense sexual secretions to flow out, age of onset can be early can evening, have plenty of birth after first day just have symptom, what have can be after general one week or an appearance later in month.
The long-term dacryocystisis of neonate, to the safety of eye is-serious threat.Carrying out property corneal ulcer or eye penetrating wound, intraocular surgery etc. all can cause panophthalmitis.Corneal infection severe patient can cause perforation of cornea, blind.
The basic principle of modern treatment is to remove lachrymal sac focus of infection, sets up Endonasal drainage passage.While adopting Drug therapy, drip the emptying lachrymal sac endocrine of the front extruding of medicine, medicinal liquid just can be inhaled into lachrymal sac; So must irrigation of lacrimal passage, so just can thoroughly remove purulence or mucus secretions, strengthen curative effect of medication.
Prior art is all to adopt normal saline flushing lachrymal sac mostly, but normal saline has certain stimulation to children's's eye, and in addition, normal saline is the effect without other auxiliary treatment to dacryocystisis.So be badly in need of developing the irrigation of lacrimal passage liquid that a kind of safety does not stimulate and can auxiliary treatment dacryocystisis.
Summary of the invention
For the problem of above-mentioned proposition, the invention provides that a kind of safety does not stimulate and children's's dacryocystisis that can auxiliary treatment dacryocystisis irrigation of lacrimal passage liquid and preparation method thereof for nursing.
Technical scheme of the present invention is: a kind of children's's dacryocystisis nursing irrigation of lacrimal passage liquid, is prepared from by the medical material of following weight proportion: Herba equiseti ramosissimi 15-25 part, Folium Mali Asiaticae 15-45 part, Herba Hieracii Umbellati 50-75 part, Herba Lysimachiae 70-120 part, Cacumen Securinegae Suffruticosae 40-70 part, Radix Gentianae 35-60 part, Flos Eriocauli 75-100 part, Sanguis Draxonis 5-15 part, Radix Et Rhizoma Rhei 15-45 part, Galla Chinensis 20-40 part, Flos Lonicerae 16-26 part, Flos Chrysanthemi Indici 20-38 part, Flos Buddlejae 18-34 part, Herba Taraxaci 16-40 part, Flos Carthami 5-15 part, Herba Rosmarini Officinalis 8-12 part, lavandula angustifolia 6-14 part.
Further, a children's's dacryocystisis nursing irrigation of lacrimal passage liquid, is prepared from by the medical material of following weight proportion: Herba equiseti ramosissimi 18-22 part, Folium Mali Asiaticae 20-40 part, Herba Hieracii Umbellati 55-70 part, Herba Lysimachiae 80-110 part, Cacumen Securinegae Suffruticosae 45-65 part, Radix Gentianae 40-55 part, Flos Eriocauli 85-90 part, Sanguis Draxonis 7-13 part, Radix Et Rhizoma Rhei 25-35 part, Galla Chinensis 25-35 part, Flos Lonicerae 20-22 part, Flos Chrysanthemi Indici 23-35 part, Flos Buddlejae 20-32 part, Herba Taraxaci 20-36 part, Flos Carthami 8-12 part, Herba Rosmarini Officinalis 9-11 part, lavandula angustifolia 8-12 part.
Further, a children's's dacryocystisis nursing irrigation of lacrimal passage liquid, is prepared from by the medical material of following weight proportion: 20 parts of Herba equiseti ramosissimis, 30 parts of Folium Mali Asiaticaes, 62.5 parts of Herba Hieracii Umbellati, 95 parts of Herba Lysimachiaes, 55 parts of Cacumen Securinegae Suffruticosaes, 47.5 parts of Radix Gentianaes, 67.5 parts of Flos Eriocaulis, 10 parts of Sanguis Draxonis, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Galla Chinensiss, 21 parts of Flos Loniceraes, 29 parts of Flos Chrysanthemi Indicis, 26 parts of Flos Buddlejaes, 28 parts of Herba Taraxacis, 10 parts, Flos Carthami, 10 parts of Herba Rosmarini Officinaliss, 10 parts of lavandula angustifoliaes.
A preparation method for irrigation of lacrimal passage liquid for the nursing of children's's dacryocystisis, comprises the following steps:
(1) by described proportioning, take Herba equiseti ramosissimi, Folium Mali Asiaticae, Herba Hieracii Umbellati, Herba Lysimachiae, Cacumen Securinegae Suffruticosae, Radix Gentianae, be placed in boiler, add the water soaking 8-16 hour doubly with respect to medical material gross mass 4-8, after big fire is boiled, use little fire instead and continue to decoct and extract 2-3 hour, filter, the medicinal residues after filtration add the water that 3-6 doubly measures and again decoct 1-2 hour, merge the extracting solution of twice, standby;
(2) by described proportioning, take Flos Eriocauli, Sanguis Draxonis, Radix Et Rhizoma Rhei, Galla Chinensis, high-temperature baking 20-30 minute, takes out, after room temperature is cooling, grind into powder, add the 65-80% soak with ethanol 4-12 hour of 3-5 times of weight, twice of reflux, extract,, each 1-3 hour, merge extractive liquid,, standby;
(3) by described proportioning take Flos Lonicerae, Flos Chrysanthemi Indici, Flos Buddlejae, Herba Taraxaci, Flos Carthami, Herba Rosmarini Officinalis, lavandula angustifolia, vacuum microwave is processed, by solid-to-liquid ratio 1:(10-20) add distilled water dynamic countercurrent extraction, extraction temperature is 80-85 ℃, extract altogether 3 times, each extraction time is 20-35 minute, merge extractive liquid,, adding distil water disperses, and stirs and makes it abundant dissolving, the aqueous dispersions that formation concentration is 0.05-0.15g/mL, aqueous dispersions passes through nonpolar macroporous adsorption resin, absorption, remove impurity, obtains extracting solution standby;
(4) extracting solution step (1) to step (3) being made mixes, adopt the decolouring of wood powder shaped activated carbon to process, 100-150 order filters, centrifugal with centrifuge 3000-5000 rev/min, after standing, get supernatant, through the ultrafiltration of ultrafiltration post, gained ultrafiltrate is children's's dacryocystisis nursing irrigation of lacrimal passage liquid of the present invention.
Further, in described step (2), baking temperature is 180-210 degree Celsius.Easy grinding more after baking, is also beneficial to the extraction of follow-up effective ingredient.
Further, in described step (3), the vacuum microwave processing time is 2-5 minute, and Microwave Power Density is 15W/g.Vacuum microwave is processed can destroy plant cell, and while making subsequent extracted, more easily stripping from cell of solute, improves extraction ratio greatly,
Further, the absorption flow velocity adsorbing by nonpolar macroporous adsorption resin in described step (3) is 1.5-4.5BV/h, and resin column blade diameter length ratio is 1: 2-8.
Further, in described step (3), remove impurity is to wash 2-5 times of resin volume with water to carry out remove impurity, and the flow velocity of water remove impurity is 1.5-4.5BV/h.Adsorption-edulcoration can make gained medicament purer.
Further, in described step (4), the molecular weight that dams of ultrafiltration post ultrafiltration is 3000-6000.Because this medicament is ophthalmic administration, so the ultrafiltration of ultrafiltration post can be demonstrate,proved the purity of medicinal liquid.
Introduce the pharmacology character of each medical material below:
Herba equiseti ramosissimi: [source] is the herb of Equisetaceae plant Herba Clinopodii Polycephali.[nature and flavor] sweetness and bitterness, flat.[function cures mainly] expelling wind and clearing away heat, dehumidifying diuresis.Control conjunctival congestion and swelling pain, pterygium, stranguria with turbid discharge, epistaxis, has blood in stool, hematuria, toothache.5. < < Traditional Chinese Medicine in Sichuan will > >: " clearing away heart-fire, removes hectic fever, scattered clouds nebula.Control epidemic hemorrhagic conjunctivitis, puckery pain, overflow tear and conjunctival congestion and swelling pain, and treat nose bleeding."
Folium Mali Asiaticae: [source] is the leaf of rosaceous plant Fructus Mali Asiaticae.[nature and flavor] are pungent; Tepor.[function cures mainly] purging pathogenic fire and improving eyesight, parasite killing removing toxic substances.Dominant eye bluish eyes is blind, pterygium, children's's scabies.
Herba Hieracii Umbellati: [source] medical material Ji Yuan: be the herb of feverfew Herba Blumeae clarkei.[nature and flavor] bitter in the mouth; Micro-pungent; Cool in nature.[function cures mainly] clearing away heat to improve acuity of vision; Dispelling wind for relieving itching; Removing toxic substances and promoting subsidence of swelling.Main conjunctival congestion and swelling pain; Pterygium; Rubella; Scabies; Skin pruritus; Carbuncle furuncle; Traumatic injury is red and swollen.
Herba Lysimachiae: meridian distribution of property and flavor; Sweet in the mouth, micro-hardship, cool in nature.Effect; Relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.
Cacumen Securinegae Suffruticosae: the micro-hardship of leaf is sweet, cool in nature, nontoxic.Enter liver spleen channel.Heat clearing away suppressing the hyperactive liver for oral administration, liver heat removing and eyesight improving, treating dysentery and diarrhoea, diuresis.External removing toxic substances and promoting subsidence of swelling.Cure mainly dysentery, summer-heat diarrhoea, enteritis, diarrhea, urinary tract infection, oedema due to nephritis, nyctalopia, acute conjunctivitis, aphtha, head sore, wind-fire acute conjunctivitis, simple indigestion, infantile malnutrition.External treatment venom, finger Serpentis skin ulcer, skin fly Serpentis ovum, children's's summer boil etc.
Flos Eriocauli: [meridian distribution of property and flavor] Xin Gan is cool.[effect] wind and heat eliminating, improving acuity of vision and removing nebula.[curing mainly] controls corneal nebula, night blindness, headache, toothache, sore throat, epistaxis.[compatibility of drugs] < < book on Chinese herbal medicine is stated > >: avoid ferrum.Join Flos Buddlejae, improving acuity of vision and removing nebula; Join Radix Saposhnikoviae, dispelling wind improving eyesight is antipruritic; Join Radix Gentianae, dispelling wind and removing heat nebula removing; Join Concha Haliotidis, the liver heat removing and eyesight improving nebula of dispelling.
Radix Gentianae: bitter in the mouth, cold in nature.Return liver, gallbladder meridian.Effect heat clearing and damp drying; Eliminating pathogen in the liver arresting convulsion.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; Hypochondriac pain bitter taste; Calentura convulsion with spasms.
Sanguis Draxonis: sweet salty, flat.[effect] takes promoting blood circulation to remove blood stasis, analgesic therapy, external hemostasia and promoting granulation, sore orally.Control traumatic injury and lose, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.2. lump in the abdomen mass in the abdomen, breast ventral spine pain.3. traumatic injury, congestion swells and ache.4. traumatic hemorrhage, ulcer being unable to heal.
Radix Et Rhizoma Rhei: nature and flavor: hardship, cold.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
Galla Chinensis: sour in the mouth is puckery, cold in nature.Effect: astringe the lung; Hidroschesis; Astringing intestine to stop diarrhea; Controlling nocturnal emission with astringent drugs; Hemostasis; Removing toxic substances.Cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; Carbuncle furuncle.< < Kaibao Bencao > >: treat tooth a surname infantile malnutrition NI, lungs pathogenic wind toxic slime flux skin style eczema, pruritus pus, hemorrhoid hematochezia is more than, children's's face nasal eczema.< < book on Chinese herbal medicine covers bamboo fish trap > >: decoct soup and wash eyes, the Akamu that disappears relieves the pain, specially the agent of convergence.< < detailed outline > >: the pathogenic fire reducing of astringing the lung, the drink that reduces phlegm, cough-relieving is coughed, quench one's thirst, night sweat, vomiting, lose blood, chronic dysentery, jaundice, cardiac and abdominal pain, the nocturnal fretfulness in infants, controls eye red wet rotten, detumescence poison, sore throat, hold back routed skin ulcer, incised wound, receive under proctoptosis, sub-intestinal pendant.
Flos Lonicerae: cold in nature, sweet in the mouth.The effect with heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Flos Chrysanthemi Indici: warm in nature; Pungent, bitter.Effect classification: antipyretic; Diaphoretic medicine; Heat and toxic materials clearing away medicine.Cure mainly: furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Laryngopharynx swelling and pain.For carbuncle, treat the swollen disease of suppurating.Removing toxic substances dispelling wind.Control order disease dizzy.Promoting pus discharge and removing toxic substances, reducing swelling and alleviating pain.Control carbuncle and treat poison, day bleb eczema.Control all conjunctival congestions, toxic swelling.Antibacterial, antivirus action, all have inhibitory action in various degree to staphylococcus aureus, escherichia coli, diphtheria corynebacterium, dysentery bacterium, bacillus pyocyaneus, Bacillus proteus.There is heat clearing away, anti-inflammatory properties
Flos Buddlejae: sweet light, be slightly cold.Have dispel the wind, the effect of removing heat from blood, profit liver, improving eyesight.Can control conjunctival congestion and swelling pain, many tear photophobia, optic atrohic blindness cataracta, the rotten eye of wind string.Clearing away heat-fire, nebula removing, liver heat removing and eyesight improving, the raw nebula film of order, hepatasthenia dim eyesight, blurring of vision, relieving cough and asthma, looks improving and the skin nourishing.< < Kaibao Bencao > >: " main optic atrohic blindness skin nebula, red puckery many eye secretion and tears, blood vessel in the order that disappears, children's's bran bean and infantile malnutrition gas are attacked eye.
Herba Taraxaci: nature and flavor: bitter sweet, cold.Function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: apply all pyogenic infections from tumour or sore, mange tinea skin ulcer; Dispel the wind, all sores that disappears, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder.< < commonly uses Chinese herbal medicine handbook > >: heat-clearing and toxic substances removing, removing pathogenic heat from blood and inducing diuresis, lactogenic.Control furuncle, skin ulcer, ophthalmic swells and ache, dyspepsia, constipation, snake bite and insect sting, urinary tract infection.
Flos Carthami: nature and flavor: pungent, temperature.Function cures mainly: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.The positive > > of < < book on Chinese herbal medicine: reach variola heat in blood difficulty and go out, the stasis of speckle rash does not disappear.
Herba Rosmarini Officinalis: Herba Rosmarini Officinalis is a kind of famous and precious natural perfume plant, and the season of growth can be distributed a kind of faint scent, the effect that having clears away heart-fire refreshes oneself.Also improve the obstacle of language, vision, audition aspect, strengthen attention, treatment rheumatalgia, strengthening liver function, reduces blood glucose, contributes to arteriosclerotic treatment, helps the extremity of the paralysis ability that reactivates.
Lavandula angustifolia: have anti-bacteria, Bergamot Mint Extract, consoles the effect of skin.
Beneficial effect of the present invention is embodied in: children's's dacryocystisis of the present invention nursing is selected the useful herbaceous plant of dacryocystisis to be prepared into pure medicinal liquid with irrigation of lacrimal passage liquid, as dacryocystisis irrigation of lacrimal passage liquid, not only can promote emptying lachrymal sac endocrine, thoroughly remove purulence or mucus secretions, strengthen curative effect of medication, also having solved the stimulation problem of existing irrigation of lacrimal passage liquid to eye, is the irrigation of lacrimal passage liquid that a kind of safety does not stimulate and can auxiliary treatment dacryocystisis.
The specific embodiment
The concrete implementation detail of various aspects of the present invention will be able to detailed description in chapters and sections below.
Embodiment 1:
A children's's dacryocystisis nursing irrigation of lacrimal passage liquid, is prepared from by the medical material of following weight proportion: 15 parts of Herba equiseti ramosissimis, 15 parts of Folium Mali Asiaticaes, 50 parts of Herba Hieracii Umbellati, 70 parts of Herba Lysimachiaes, 40 parts of Cacumen Securinegae Suffruticosaes, 35 parts of Radix Gentianaes, 75 parts of Flos Eriocaulis, 5 parts of Sanguis Draxonis, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Galla Chinensiss, 16 parts of Flos Loniceraes, 20 parts of Flos Chrysanthemi Indicis, 18 parts of Flos Buddlejaes, 16 parts of Herba Taraxacis, 5 parts, Flos Carthami, 8 parts of Herba Rosmarini Officinaliss, 6 parts of lavandula angustifoliaes.
Its preparation method is:
(1) by described proportioning, take Herba equiseti ramosissimi, Folium Mali Asiaticae, Herba Hieracii Umbellati, Herba Lysimachiae, Cacumen Securinegae Suffruticosae, Radix Gentianae, be placed in boiler, add with respect to the water soaking of 4 times of medical material gross masses 8 hours, after big fire is boiled, use little fire instead and continue to decoct extraction 2 hours, filter, the water that the medicinal residues after filtration add 3 times of amounts decocts 1 hour again, merge the extracting solution of twice, standby;
(2) by described proportioning, take Flos Eriocauli, Sanguis Draxonis, Radix Et Rhizoma Rhei, Galla Chinensis, high-temperature baking 20 minutes, baking temperature is 180 degrees Celsius, takes out, after room temperature is cooling, grind into powder, add 65% soak with ethanol 4 hours of 3 times of weight, twice of reflux, extract,, each 1 hour, merge extractive liquid,, standby; Easy grinding more after baking, is also beneficial to the extraction of follow-up effective ingredient;
(3) by described proportioning take Flos Lonicerae, Flos Chrysanthemi Indici, Flos Buddlejae, Herba Taraxaci, Flos Carthami, Herba Rosmarini Officinalis, lavandula angustifolia, vacuum microwave is processed, the vacuum microwave processing time is 2 minutes, Microwave Power Density is 15W/g, vacuum microwave is processed can destroy plant cell, while making subsequent extracted, more easily stripping from cell of solute, improves extraction ratio greatly; By solid-to-liquid ratio 1:10, add distilled water dynamic countercurrent extraction, extracting temperature is 80 ℃, extract altogether 3 times, each extraction time is 20 minutes, merge extractive liquid,, adding distil water disperses, stir and make it abundant dissolving, the aqueous dispersions that formation concentration is 0.05g/mL, aqueous dispersions passes through nonpolar macroporous adsorption resin, absorption flow velocity is 1.5BV/h, and resin column blade diameter length ratio is 1: 2; Wash 2 times of resin volumes with water and carry out remove impurity, the flow velocity of water remove impurity is 1.5BV/h, and adsorption-edulcoration can make gained medicament purer, obtains extracting solution standby;
(4) extracting solution step (1) to step (3) being made mixes, adopt the decolouring of wood powder shaped activated carbon to process, 100 orders filter, centrifugal with 3000 revs/min, centrifuge, standing after, get supernatant, through the ultrafiltration of ultrafiltration post, the molecular weight that dams of ultrafiltration post ultrafiltration is 3000, because this medicament is ophthalmic administration, so the ultrafiltration of ultrafiltration post can be demonstrate,proved the purity of medicinal liquid, gained ultrafiltrate is children's's dacryocystisis nursing irrigation of lacrimal passage liquid of the present invention.
Embodiment 2:
A children's's dacryocystisis nursing irrigation of lacrimal passage liquid, is prepared from by the medical material of following weight proportion: 20 parts of Herba equiseti ramosissimis, 30 parts of Folium Mali Asiaticaes, 62.5 parts of Herba Hieracii Umbellati, 95 parts of Herba Lysimachiaes, 55 parts of Cacumen Securinegae Suffruticosaes, 47.5 parts of Radix Gentianaes, 67.5 parts of Flos Eriocaulis, 10 parts of Sanguis Draxonis, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Galla Chinensiss, 21 parts of Flos Loniceraes, 29 parts of Flos Chrysanthemi Indicis, 26 parts of Flos Buddlejaes, 28 parts of Herba Taraxacis, 10 parts, Flos Carthami, 10 parts of Herba Rosmarini Officinaliss, 10 parts of lavandula angustifoliaes.
Its preparation method is:
(1) by described proportioning, take Herba equiseti ramosissimi, Folium Mali Asiaticae, Herba Hieracii Umbellati, Herba Lysimachiae, Cacumen Securinegae Suffruticosae, Radix Gentianae, be placed in boiler, add with respect to the water soaking of 6 times of medical material gross masses 12 hours, after big fire is boiled, use little fire instead and continue to decoct extraction 2.5 hours, filter, the water that the medicinal residues after filtration add 4.5 times of amounts decocts 1.5 hours again, merge the extracting solution of twice, standby;
(2) by described proportioning, take Flos Eriocauli, Sanguis Draxonis, Radix Et Rhizoma Rhei, Galla Chinensis, high-temperature baking 25 minutes, baking temperature is 195 degrees Celsius, takes out, after room temperature is cooling, grind into powder, add 72.5% soak with ethanol 8 hours of 4 times of weight, twice of reflux, extract,, each 2 hours, merge extractive liquid,, standby; Easy grinding more after baking, is also beneficial to the extraction of follow-up effective ingredient;
(3) by described proportioning take Flos Lonicerae, Flos Chrysanthemi Indici, Flos Buddlejae, Herba Taraxaci, Flos Carthami, Herba Rosmarini Officinalis, lavandula angustifolia, vacuum microwave is processed, the vacuum microwave processing time is 3.5 minutes, Microwave Power Density is 15W/g, vacuum microwave is processed can destroy plant cell, while making subsequent extracted, more easily stripping from cell of solute, improves extraction ratio greatly; By solid-to-liquid ratio 1:15, add distilled water dynamic countercurrent extraction, extracting temperature is 82.5 ℃, extract altogether 3 times, each extraction time is 27.5 minutes, merge extractive liquid,, adding distil water disperses, stir and make it abundant dissolving, the aqueous dispersions that formation concentration is 0.10g/mL, aqueous dispersions passes through nonpolar macroporous adsorption resin, absorption flow velocity is 3.0 BV/h, and resin column blade diameter length ratio is 1: 5; Wash 3.5 times of resin volumes with water and carry out remove impurity, the flow velocity of water remove impurity is 3.0 BV/h, and adsorption-edulcoration can make gained medicament purer, obtains extracting solution standby;
(4) extracting solution step (1) to step (3) being made mixes, adopt the decolouring of wood powder shaped activated carbon to process, 125 orders filter, centrifugal with 4000 revs/min, centrifuge, standing after, get supernatant, through the ultrafiltration of ultrafiltration post, the molecular weight that dams of ultrafiltration post ultrafiltration is 4500, because this medicament is ophthalmic administration, so the ultrafiltration of ultrafiltration post can be demonstrate,proved the purity of medicinal liquid, gained ultrafiltrate is children's's dacryocystisis nursing irrigation of lacrimal passage liquid of the present invention.
Embodiment 3:
A children's's dacryocystisis nursing irrigation of lacrimal passage liquid, is prepared from by the medical material of following weight proportion: 25 parts of Herba equiseti ramosissimis, 45 parts of Folium Mali Asiaticaes, 75 parts of Herba Hieracii Umbellati, 120 parts of Herba Lysimachiaes, 70 parts of Cacumen Securinegae Suffruticosaes, 60 parts of Radix Gentianaes, 100 parts of Flos Eriocaulis, 15 parts of Sanguis Draxonis, 45 parts of Radix Et Rhizoma Rhei, 40 parts of Galla Chinensiss, 26 parts of Flos Loniceraes, 38 parts of Flos Chrysanthemi Indicis, 34 parts of Flos Buddlejaes, 40 parts of Herba Taraxacis, 15 parts, Flos Carthami, 12 parts of Herba Rosmarini Officinaliss, 14 parts of lavandula angustifoliaes.
Its preparation method is:
(1) by described proportioning, take Herba equiseti ramosissimi, Folium Mali Asiaticae, Herba Hieracii Umbellati, Herba Lysimachiae, Cacumen Securinegae Suffruticosae, Radix Gentianae, be placed in boiler, add with respect to the water soaking of 8 times of medical material gross masses 16 hours, after big fire is boiled, use little fire instead and continue to decoct extraction 3 hours, filter, the water that the medicinal residues after filtration add 6 times of amounts decocts 2 hours again, merge the extracting solution of twice, standby;
(2) by described proportioning, take Flos Eriocauli, Sanguis Draxonis, Radix Et Rhizoma Rhei, Galla Chinensis, high-temperature baking 30 minutes, baking temperature is 210 degrees Celsius, takes out, after room temperature is cooling, grind into powder, add 80% soak with ethanol 12 hours of 5 times of weight, twice of reflux, extract,, each 3 hours, merge extractive liquid,, standby; Easy grinding more after baking, is also beneficial to the extraction of follow-up effective ingredient;
(3) by described proportioning take Flos Lonicerae, Flos Chrysanthemi Indici, Flos Buddlejae, Herba Taraxaci, Flos Carthami, Herba Rosmarini Officinalis, lavandula angustifolia, vacuum microwave is processed, the vacuum microwave processing time is 5 minutes, Microwave Power Density is 15W/g, vacuum microwave is processed can destroy plant cell, while making subsequent extracted, more easily stripping from cell of solute, improves extraction ratio greatly; By solid-to-liquid ratio 1:20, add distilled water dynamic countercurrent extraction, extracting temperature is 85 ℃, extract altogether 3 times, each extraction time is 35 minutes, merge extractive liquid,, adding distil water disperses, stir and make it abundant dissolving, the aqueous dispersions that formation concentration is 0.15g/mL, aqueous dispersions passes through nonpolar macroporous adsorption resin, absorption flow velocity is 4.5BV/h, and resin column blade diameter length ratio is 1: 8; Wash 5 times of resin volumes with water and carry out remove impurity, the flow velocity of water remove impurity is 4.5BV/h, and adsorption-edulcoration can make gained medicament purer, obtains extracting solution standby;
(4) extracting solution step (1) to step (3) being made mixes, adopt the decolouring of wood powder shaped activated carbon to process, 150 orders filter, centrifugal with 5000 revs/min, centrifuge, standing after, get supernatant, through the ultrafiltration of ultrafiltration post, the molecular weight that dams of ultrafiltration post ultrafiltration is 6000, because this medicament is ophthalmic administration, so the ultrafiltration of ultrafiltration post can be demonstrate,proved the purity of medicinal liquid, gained ultrafiltrate is children's's dacryocystisis nursing irrigation of lacrimal passage liquid of the present invention.
Compliance test result:
Each irrigation of lacrimal passage liquid of below being prepared by above-described embodiment 1-3 carries out clinical effectiveness experiment.
1. test grouping:
120 examples suffer from the patient of dacryocystisis, are divided at random 4 groups, and every group of 30 people are respectively one group for the treatment of, two groups of treatments, treatment three groups, matched group.
2. test method:
Treating one group of all patient uses children's's dacryocystisis nursing of the embodiment of the present invention 1 preparation to carry out eye flushing with irrigation of lacrimal passage liquid;
Treating two groups of all patients uses children's's dacryocystisis nursing of the embodiment of the present invention 2 preparations to carry out eye flushing with irrigation of lacrimal passage liquid;
Treating three groups of all patients uses children's's dacryocystisis nursing of the embodiment of the present invention 3 preparations to carry out eye flushing with irrigation of lacrimal passage liquid;
The all patients of matched group use conventional clinically normal saline: 0.85% sodium chloride aseptic aqueous solution carries out eye flushing.
3. the method for inspection:
(1) lachrymal sac endocrine is emptying: each organize all patients respectively according to above-mentioned arrangement and use separately flushing liquor eye is rinsed, check in lachrymal sac whether purulence or mucus secretions clean up.
(2) cure rate: according to clinical normal therapeutic method, all patients are carried out to completely same treatment, unique different be that the irrigation of lacrimal passage liquid that uses is different, finally add up Cure.
4. result statistics is as shown in Table 1:
Table one: experimental result statistics
5. result of the test: from the data of above-mentioned table one statistics, use children's's dacryocystisis nursing prepared by the present invention treat eye flushing in earlier stage with irrigation of lacrimal passage liquid, with respect to normal saline, the first, eye portion secretion Emptying Rate is high, emptying effective; The second, from Cure, the cure rate of a course for the treatment of and the cure rate of two courses for the treatment of are all higher.As can be seen here, children's's dacryocystisis nursing of the present invention possesses good developing result with irrigation of lacrimal passage liquid, and dacryocystisis is had to certain auxiliary therapeutic action.
Finally it should be noted that: above embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record previous embodiment is modified, or part technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (9)
1. an irrigation of lacrimal passage liquid is used in the nursing of children's's dacryocystisis, it is characterized in that being prepared from by the medical material of following weight proportion: Herba equiseti ramosissimi 15-25 part, Folium Mali Asiaticae 15-45 part, Herba Hieracii Umbellati 50-75 part, Herba Lysimachiae 70-120 part, Cacumen Securinegae Suffruticosae 40-70 part, Radix Gentianae 35-60 part, Flos Eriocauli 75-100 part, Sanguis Draxonis 5-15 part, Radix Et Rhizoma Rhei 15-45 part, Galla Chinensis 20-40 part, Flos Lonicerae 16-26 part, Flos Chrysanthemi Indici 20-38 part, Flos Buddlejae 18-34 part, Herba Taraxaci 16-40 part, Flos Carthami 5-15 part, Herba Rosmarini Officinalis 8-12 part, lavandula angustifolia 6-14 part.
2. irrigation of lacrimal passage liquid is used in a kind of children's's dacryocystisis nursing as claimed in claim 1, it is characterized in that being prepared from by the medical material of following weight proportion: Herba equiseti ramosissimi 18-22 part, Folium Mali Asiaticae 20-40 part, Herba Hieracii Umbellati 55-70 part, Herba Lysimachiae 80-110 part, Cacumen Securinegae Suffruticosae 45-65 part, Radix Gentianae 40-55 part, Flos Eriocauli 85-90 part, Sanguis Draxonis 7-13 part, Radix Et Rhizoma Rhei 25-35 part, Galla Chinensis 25-35 part, Flos Lonicerae 20-22 part, Flos Chrysanthemi Indici 23-35 part, Flos Buddlejae 20-32 part, Herba Taraxaci 20-36 part, Flos Carthami 8-12 part, Herba Rosmarini Officinalis 9-11 part, lavandula angustifolia 8-12 part.
3. irrigation of lacrimal passage liquid is used in a kind of children's's dacryocystisis nursing as claimed in claim 1, it is characterized in that being prepared from by the medical material of following weight proportion: 20 parts of Herba equiseti ramosissimis, 30 parts of Folium Mali Asiaticaes, 62.5 parts of Herba Hieracii Umbellati, 95 parts of Herba Lysimachiaes, 55 parts of Cacumen Securinegae Suffruticosaes, 47.5 parts of Radix Gentianaes, 67.5 parts of Flos Eriocaulis, 10 parts of Sanguis Draxonis, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Galla Chinensiss, 21 parts of Flos Loniceraes, 29 parts of Flos Chrysanthemi Indicis, 26 parts of Flos Buddlejaes, 28 parts of Herba Taraxacis, 10 parts, Flos Carthami, 10 parts of Herba Rosmarini Officinaliss, 10 parts of lavandula angustifoliaes.
4. the children's's dacryocystisis as described in claim 1-3 any one is nursed the preparation method with irrigation of lacrimal passage liquid, it is characterized in that comprising the following steps:
(1) by described proportioning, take Herba equiseti ramosissimi, Folium Mali Asiaticae, Herba Hieracii Umbellati, Herba Lysimachiae, Cacumen Securinegae Suffruticosae, Radix Gentianae, add the water soaking 8-16 hour doubly with respect to medical material gross mass 4-8, after big fire is boiled, use little fire instead and continue to decoct 2-3 hour, filter, medicinal residues add the water that 3-6 doubly measures and again decoct 1-2 hour, merge the extracting solution of twice, standby;
(2) by described proportioning, take Flos Eriocauli, Sanguis Draxonis, Radix Et Rhizoma Rhei, Galla Chinensis, high-temperature baking 20-30 minute, grinds into powder after cooling, adds 65-80% soak with ethanol 4-12 hour, extracts twice, each 1-3 hour, and merge extractive liquid,, standby;
(3) by described proportioning take Flos Lonicerae, Flos Chrysanthemi Indici, Flos Buddlejae, Herba Taraxaci, Flos Carthami, Herba Rosmarini Officinalis, lavandula angustifolia, vacuum microwave is processed, by solid-to-liquid ratio 1:(10-20) add distilled water dynamic countercurrent extraction, extraction temperature is 80-85 ℃, extract altogether each 20-35 minute, merge extractive liquid, 3 times, adding aqueous dispersion dissolves, form aqueous dispersions, aqueous dispersions, by nonpolar macroporous adsorption resin, adsorbs, remove impurity, obtains extracting solution standby;
(4) extracting solution step (1) to step (3) being made mixes, through activated carbon decolorizing, process, 100-150 order filters, centrifugal through 3000-5000 rev/min, get the supernatant after centrifugal, through the ultrafiltration of ultrafiltration post, gained ultrafiltrate is children's's dacryocystisis nursing irrigation of lacrimal passage liquid of the present invention.
5. the preparation method of irrigation of lacrimal passage liquid for a kind of children's's dacryocystisis nursing as claimed in claim 4, is characterized in that in described step (2), baking temperature is 180-210 degree Celsius.
6. the preparation method of irrigation of lacrimal passage liquid for a kind of children's's dacryocystisis nursing as claimed in claim 4, is characterized in that in described step (3) that the vacuum microwave processing time is 2-5 minute, and Microwave Power Density is 15W/g.
7. a kind of children's's dacryocystisis as claimed in claim 4 is nursed the preparation method with irrigation of lacrimal passage liquid, it is characterized in that the absorption flow velocity adsorbing by nonpolar macroporous adsorption resin in described step (3) is 1.5-4.5BV/h, resin column blade diameter length ratio is 1: 2-8.
8. the preparation method of irrigation of lacrimal passage liquid for a kind of children's's dacryocystisis nursing as claimed in claim 4, is characterized in that in described step (3), remove impurity is to wash 2-5 times of resin volume with water to carry out remove impurity, and the flow velocity of water remove impurity is 1.5-4.5BV/h.
9. the preparation method of irrigation of lacrimal passage liquid for a kind of children's's dacryocystisis nursing as claimed in claim 4, is characterized in that the molecular weight that dams of ultrafiltration post ultrafiltration in described step (4) is 3000-6000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410443306.4A CN104189335A (en) | 2014-09-02 | 2014-09-02 | Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410443306.4A CN104189335A (en) | 2014-09-02 | 2014-09-02 | Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104189335A true CN104189335A (en) | 2014-12-10 |
Family
ID=52074807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410443306.4A Pending CN104189335A (en) | 2014-09-02 | 2014-09-02 | Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104189335A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362533A (en) * | 2015-12-23 | 2016-03-02 | 许立华 | Nursing lacrimal passage flushing fluid for infantile dacryocystitis and preparation method of flushing fluid |
| CN106074846A (en) * | 2016-06-19 | 2016-11-09 | 刘斌 | A kind of wiping agent treating neonatal dacryocystitis and preparation method thereof |
| CN106267151A (en) * | 2016-08-22 | 2017-01-04 | 高伟荣 | Irrigation of lacrimal passage liquid is used in a kind of children's's dacryocystisis nursing |
| CN112402324A (en) * | 2020-12-10 | 2021-02-26 | 广州市柏菲化妆品有限公司 | Lavender hand cleaning solution and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152354A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating acute dacryocystitis |
| CN101152343A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating chronic dacryocystitis |
| CN101797332A (en) * | 2010-04-15 | 2010-08-11 | 滕淑玲 | Traditional Chinese medicine for treating chronic dacryocystitis and preparation method thereof |
| CN101890054A (en) * | 2009-05-21 | 2010-11-24 | 上海凯宝药业股份有限公司 | Method for preparing Chinese medicinal injection |
-
2014
- 2014-09-02 CN CN201410443306.4A patent/CN104189335A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152354A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating acute dacryocystitis |
| CN101152343A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating chronic dacryocystitis |
| CN101890054A (en) * | 2009-05-21 | 2010-11-24 | 上海凯宝药业股份有限公司 | Method for preparing Chinese medicinal injection |
| CN101797332A (en) * | 2010-04-15 | 2010-08-11 | 滕淑玲 | Traditional Chinese medicine for treating chronic dacryocystitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄庆山: "中药冲洗泪道治疗慢性泪囊炎110例疗效观察"", 《中药冲洗泪道治疗慢性泪囊炎110例疗效观察》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362533A (en) * | 2015-12-23 | 2016-03-02 | 许立华 | Nursing lacrimal passage flushing fluid for infantile dacryocystitis and preparation method of flushing fluid |
| CN106074846A (en) * | 2016-06-19 | 2016-11-09 | 刘斌 | A kind of wiping agent treating neonatal dacryocystitis and preparation method thereof |
| CN106267151A (en) * | 2016-08-22 | 2017-01-04 | 高伟荣 | Irrigation of lacrimal passage liquid is used in a kind of children's's dacryocystisis nursing |
| CN112402324A (en) * | 2020-12-10 | 2021-02-26 | 广州市柏菲化妆品有限公司 | Lavender hand cleaning solution and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102205026B (en) | Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof | |
| CN103877429B (en) | A kind of Chinese medicine preparation and preparation method for the treatment of sinusitis | |
| CN104189335A (en) | Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof | |
| CN101601782A (en) | A kind of compound spirit for the treatment of tinea pedis | |
| CN103495072B (en) | Traditional Chinese medicine composition treating bronchiectasia disease and preparation method thereof | |
| CN105125630A (en) | Eye drops and preparation method thereof | |
| CN104958581A (en) | Chinese herbal preparation for treating epifolliculitis and preparing method of Chinese herbal preparation for treating epifolliculitis | |
| CN104587043A (en) | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof | |
| CN105395587A (en) | Traditional Chinese medicine reagent used for treating nose problems and preparation method thereof | |
| CN104189489A (en) | Medicament with effect of treating chronic eczema and preparation method thereof | |
| CN102357160B (en) | Chinese medicine for treating malaria | |
| CN103417782A (en) | Traditional Chinese medicine for treating scald | |
| CN104547653B (en) | A kind of Chinese prescription for treating chronic nasosinusitis | |
| CN105250571A (en) | Spray preparation for treating liver and gall fire exuberance type acute suppurative otitis media | |
| CN104997949A (en) | Traditional Chinese medicine for treating rhinitis and preparation method thereof | |
| CN104523850A (en) | Medicine composition for treating rhinitis and nasosinusitis | |
| CN105395765A (en) | External application traditional Chinese medicine preparation for treating chronic nasosinusitis | |
| CN105030936A (en) | Chinese medicine for treating keratoconjunctivitis | |
| CN104189154B (en) | A kind of Chinese medicine preparation for the treatment of viral conjunctivitis | |
| CN104971158A (en) | Traditional Chinese medicine for treating dry eyes | |
| CN104524068A (en) | Traditional Chinese medicine eye drops for treating pinkeye and preparation method | |
| CN104740200A (en) | Traditional Chinese medicine spray for treating nasal obstruction caused by chronic nasosinusitis and preparation method of traditional Chinese medicine spray | |
| CN103721061A (en) | External traditional Chinese medicine preparation for treating chronic nasosinusitis and preparation method thereof | |
| CN103690636A (en) | Traditional Chinese medicinal prescription for treating rhinitis | |
| CN103908557A (en) | Traditional Chinese medicine for treating cholesteatoma otitis media |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141210 |