CN1374114A - New prepn process of Lideri as one traditional Mongoliam medicine - Google Patents
New prepn process of Lideri as one traditional Mongoliam medicine Download PDFInfo
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- CN1374114A CN1374114A CN 02103956 CN02103956A CN1374114A CN 1374114 A CN1374114 A CN 1374114A CN 02103956 CN02103956 CN 02103956 CN 02103956 A CN02103956 A CN 02103956A CN 1374114 A CN1374114 A CN 1374114A
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- sophorae flavescentis
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Abstract
The preparation process of lideri-4 as one traditional Mongolian medicine includes washing, stoving, crushing and water soaking seven medicine materials including flavescent sophora root, elecampane, myrobalan fruit, cape jasmine, Sichuan chinaberry fruit, viola yedoensis and figwortflower picrorhiza rhizome; decocting the soaked medicine materials in water to obtain decoction; merging decoction and concentration to obtain liquid extract; mixing with stevioside to correct taste, pelletizing while steam or boiling drying and packing. The traditional Mongolian medicine Lideri-4 is easy to take and has high curative effect.
Description
Invention field
The present invention relates to the new preparation process of mongolian medicine Saorilao-7 granule.
Background technology
Saorilao-7 flavor granule has another name called seven flavor kuh-seng soups.This medicine is by the name of traditional prescription seven flavor diaphoresis soup, comes from " onlooker's happiness " book.By Radix Sophorae Flavescentis 50, Radix Inulae 50, the Fructus Chebulae 45, Fructus Toosendan 45, Fructus Gardeniae 45, Herba Violae 40, Rhizoma Picrorhizae 25, seven flavor medicine combines.This medicine function is: can make heat maturation, diaphoresis, rash, cure mainly: the conspicuous friendship according to blood of immature fever, plague fever, flu, measles, lung-heat won etc.The side separates: we are cool in nature, and based on the Radix Sophorae Flavescentis of heat clearing away diaphoresis, with flat qi and blood disorder, it is auxilliary making the sophisticated Radix Inulae of plague fever in the side; To impel the heat in blood maturation, disturb heat, expectorant heat with three sons, Herba Violae, Rhizoma Picrorhizae clearly.So make functions such as calentura maturation, diaphoresis heat clearing away.
Summary of the invention
This Fang Jing studies for many years, changes drawbacks such as taking inconvenience, makes granule granule or powder preparation to be taken after being infused in boiling water of the present invention, and it is satisfied to go through the several years clinical application effect.
Preparation method of the present invention comprises:
A, take by weighing seven flavor medicines such as Radix Sophorae Flavescentis, Radix Inulae and be ground into coarse powder (about 10 orders), add the water-wet of distilled water (or deionized water) doubling dose, placed about 60 minutes, allow the abundant imbibition of medical material, so that extract complete through selecting crude drugs with winnower or washing oven dry.
B, expansible medical material put add the distillation water boiling and extraction that is equivalent to 5 times of doses or 10 times in the extraction pot, generally extract 3 times, be respectively 1h, 0.5h, 0.5h at every turn, merging filtrate, medicinal residues discard.If this product water soluble ingredient is many, it is good all to adopt the water concentration to be condensed to.It is suitable that concentrated volume can determine whether according to the concentration of fluid extract.General requirement (1: 1) concentration is good.
C, the fluid extract that obtains can be used for craft or machine system soft material, after the good amount of calculating, add dextrin (beta-schardinger dextrin-), as the rich stevioside flavoring that adds, and after soft material is even, last granulation machine granulation, wet granular is in 60-80 ℃ of drying of circulation steam.But also airpillow-dry, dried granule be again by the granulation machine granulate, at last the single-size agent, can pack.
Wherein each amounts of components proportioning is: Radix Sophorae Flavescentis 25-75, Radix Inulae 25-75, Fructus Chebulae 30-70, Fructus Toosendan 30-70, Fructus Gardeniae 30-70, Herba Violae 20-60, Rhizoma Picrorhizae 15-40 is preferably Radix Sophorae Flavescentis 50, Radix Inulae 50, the Fructus Chebulae 45, Fructus Toosendan 45, Fructus Gardeniae 45, Herba Violae 40, Rhizoma Picrorhizae 25.
Technological process of the present invention as shown in Figure 1.
The medicinal application of prepared of the present invention is compared with conventional dosage forms in clinical, finds that effective percentage improves about 8-10%.
Embodiment
Take by weighing seven flavor medicines such as Radix Sophorae Flavescentis, Radix Inulae and be ground into coarse powder about 10 orders, add the water-wet of distilled water doubling dose, placed about 60 minutes, allow the abundant imbibition of medical material, so that extract complete through selecting crude drugs with winnower or washing oven dry.
Expansible medical material put add the distillation water boiling and extraction that is equivalent to 5 times of doses in the extraction pot, extract 3 times, be respectively 1h, 0.5h, 0.5h at every turn.Merging filtrate, medicinal residues discard.Be concentrated into (1: 1).
The fluid extract system soft material that obtains after the good amount of calculating, adds dextrin (beta-schardinger dextrin-), adds the stevioside flavoring, and after soft material was even, last granulation machine was granulated, and wet granular is in 70 ℃ of dryings of circulation steam.Dried granule gets the single-size agent at last again by the granulation machine granulate, can pack.
This granule is based on the monarch drug Radix Sophorae Flavescentis, so quality standard is as the criterion with Radix Sophorae Flavescentis.Inspection method: the assay of Radix Sophorae Flavescentis.
This mensuration is educated 1981 16 volumes of medium Acta Pharmaceutica Sinica, 4 phase 282-288 methods with reference to chapter and is carried out.
Colorimetric method for determining
Precision takes by weighing 1 part of 5g crude drug, puts in the 100ml ground triangular flask, adds soaked overnight after the close plug jolting of chloroform 200ml (including strong aqua ammonia 2ml), filters with Cotton Gossypii then.
Accurate filtrate 15ml (the being equivalent to crude drug 0.375g) evaporate to dryness of drawing, with anhydrous alcohol solution and transfer in the 5ml volumetric flask, redilution is to scale.
Draw Thin-layer separation and the colorimetric estimation method operation that diluent 20 microlitres are pressed Radix Sophorae Flavescentis in the injection with capillary tube, measurement result is as follows:
The advantage of this method is the matrine in Radix Sophorae Flavescentis and preparation thereof, and oxymatrine etc. form ion pair with bromothymol blue in the pH7.6 buffer after the silica gel G Thin-layer separation, behind chloroform extraction, can carry out colorimetric determination.Total alkaloids gets final product colorimetric determination through Thin-layer separation.Measurement result is accurate, favorable reproducibility.So can be used on the quality control of this granule.
Claims (4)
1, the new preparation process of mongolian medicine Saorilao-7 granule comprises:
A, take by weighing Radix Sophorae Flavescentis, Radix Inulae, Fructus Chebulae, Fructus Toosendan, Fructus Gardeniae, Herba Violae, Rhizoma Picrorhizae seven flavor medicine and be ground into coarse powder, add the doubling dose water-wet, place, allow the abundant imbibition of medical material, so that extract fully through selecting crude drugs with winnower or washing oven dry;
B, expansible medical material put to add in the extraction pot be equivalent to dose 5-10 water boiling and extraction doubly, merging filtrate, medicinal residues discard, and reconcentration becomes fluid extract;
C, the fluid extract system soft material that obtains after the good amount of calculating, add carrier, optional adding stevioside flavoring; after soft material was even, last granulation machine was granulated, and wet granular is at circulation 60-80 ℃ of drying of steam or airpillow-dry; dried granule gets the single-size agent at last again by the granulation machine granulate, can pack.
2, according to the technology of claim 1, wherein the proportioning by weight of each component is: Radix Sophorae Flavescentis 25-75, Radix Inulae 25-75, Fructus Chebulae 30-70, Fructus Toosendan 30-70, Fructus Gardeniae 30-70, Herba Violae 20-60, Rhizoma Picrorhizae 15-40.
3, according to the technology of claim 1, wherein the proportioning by weight of each component is: Radix Sophorae Flavescentis 50, and Radix Inulae 50, the Fructus Chebulae 45, Fructus Toosendan 45, Fructus Gardeniae 45, Herba Violae 40, Rhizoma Picrorhizae 25.
4, the product that obtains according to the preparation technology of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021039569A CN1165328C (en) | 2002-02-27 | 2002-02-27 | New prepn process of Lideri as one traditional Mongoliam medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021039569A CN1165328C (en) | 2002-02-27 | 2002-02-27 | New prepn process of Lideri as one traditional Mongoliam medicine |
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| Publication Number | Publication Date |
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| CN1374114A true CN1374114A (en) | 2002-10-16 |
| CN1165328C CN1165328C (en) | 2004-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021039569A Expired - Fee Related CN1165328C (en) | 2002-02-27 | 2002-02-27 | New prepn process of Lideri as one traditional Mongoliam medicine |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302596A (en) * | 2011-09-08 | 2012-01-04 | 内蒙古民族大学 | Mongolian medicament for treating skin inflammations and gynecological inflammations |
| CN106728455A (en) * | 2017-02-20 | 2017-05-31 | 陶乌日娜 | A kind of externally used Mongolian medicine composition for treating dermatitis, eczema and preparation method thereof |
| CN106949714A (en) * | 2016-12-06 | 2017-07-14 | 内蒙古库伦蒙药有限公司 | A kind of anaesthetic water-bindered pill automatic control humiture furnace drying method and drying system |
| CN109432165A (en) * | 2018-12-22 | 2019-03-08 | 内蒙古民族大学附属医院 | A kind of anaesthetic and preparation method thereof for treating asthma |
-
2002
- 2002-02-27 CN CNB021039569A patent/CN1165328C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302596A (en) * | 2011-09-08 | 2012-01-04 | 内蒙古民族大学 | Mongolian medicament for treating skin inflammations and gynecological inflammations |
| CN102302596B (en) * | 2011-09-08 | 2013-05-08 | 内蒙古民族大学 | Mongolian medicament for treating skin inflammations and gynecological inflammations |
| CN106949714A (en) * | 2016-12-06 | 2017-07-14 | 内蒙古库伦蒙药有限公司 | A kind of anaesthetic water-bindered pill automatic control humiture furnace drying method and drying system |
| CN106728455A (en) * | 2017-02-20 | 2017-05-31 | 陶乌日娜 | A kind of externally used Mongolian medicine composition for treating dermatitis, eczema and preparation method thereof |
| CN109432165A (en) * | 2018-12-22 | 2019-03-08 | 内蒙古民族大学附属医院 | A kind of anaesthetic and preparation method thereof for treating asthma |
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| Publication number | Publication date |
|---|---|
| CN1165328C (en) | 2004-09-08 |
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Granted publication date: 20040908 Termination date: 20130227 |