CN105288516A

CN105288516A - Traditional Chinese medicine composition for treating chronic cholecystitis

Info

Publication number: CN105288516A
Application number: CN201510907795.9A
Authority: CN
Inventors: 陆仲新
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-09
Filing date: 2015-12-09
Publication date: 2016-02-03

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic cholecystitis. The composition is prepared from the following medicinal raw materials in parts by weight: 20-30 parts of lophatherum gracile, 20-25 parts of tetrapanax papyriferus, 10-15 parts of rhizoma smilacis glabrae, 10-15 parts of Japanese clover, 8-10 parts of herba hyperici japonici, 10-20 parts of herba pteridis multifidae, 8-15 parts of radix isatidis, 20-30 parts of felwort, 10-20 parts of radix paeoniae alba, 8-20 parts of rhizoma cyperi, 10-30 parts of rhizoma atractylodis macrocephalae, 10-30 parts of mulberry leaves, 5-15 parts of selfheal, 8-15 parts of chrysanthemum, 5-10 parts of radix curcuma, 8-10 parts of dalbergia odorifera, 10-20 parts of rose flower, 20-25 parts of bamboo shavings, 10-20 parts of dandelion, 10-20 parts of radix isatidis, 10-20 parts of perilla frutescens, 3-8 parts of coptis chinensis and 1-3 parts of sedum verticallatum. The traditional Chinese medicine composition has remarkable effects of relieving inflammation, relieving pain and promoting bile flow.

Description

A kind of Chinese medicine composition for the treatment of chronic cholecystitis

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of chronic cholecystitis.

Background technology

Chronic cholecystitis (chroniccholecystitis) means gallbladder chronic inflammation pathological changes, be mostly chronic venous insufficiency, account for 85% ~ 95%, minority is non-calcareous cholecystitis, as typhoid carrier, primary disease can be delayed by acute cholecystitis recurrent exerbation, also can chronic onset, and clinical manifestation is without specificity, commonly right upper quadrant of the abdomen or precordial region dull pain, glutted discomfort after food, belch, can have nauseating after feed greasy food, occasionally there is vomiting, old people, can, without clinical symptoms, claim silent gallbladder scorching.The Chinese patent medicine curative effect of the treatment capsule inflammation of having gone on the market at present is slow, poor effect.

Summary of the invention

For above-mentioned prior art, the invention provides the Chinese medicine composition of the treatment chronic cholecystitis that a kind of curative effect is fast, therapeutic effect is good.

The present invention is achieved by the following technical solutions:

A kind of Chinese medicine composition for the treatment of chronic cholecystitis, it is characterized in that, it is be made up of the crude drug of following weight portion: Herba Lophatheri 20-30 part, Medulla Tetrapanacis 20-25 part, Rhizoma Smilacis Glabrae 10-15 part, Herba Kummerowiae Striatae 10-15 part, Herba Hyperici Japonici 8-10 part, Herba Pteridis Multifidae 10-20 part, Radix Isatidis 8-15 part, Radix Gentianae 20-30 part, Radix Paeoniae Alba 10-20 part, Rhizoma Cyperi 8-20 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Folium Mori 10-30 part, Spica Prunellae 5-15 part, Flos Chrysanthemi 8-15 part, Rhizoma Curcumae Longae 5-10 part, Lignum Dalbergiae Odoriferae 8-10 part, Flos Rosae Rugosae 10-20 part, Caulis Bambusae In Taenia 20-25 part, Herba Taraxaci 10-20 part, Radix Isatidis 10-20 part, Folium Perillae 10-20 part, Rhizoma Coptidis 3-8 part, Herba Sedi 1-3 part.

Preferably: be made up of the crude drug of following weight portion: Herba Lophatheri 20 parts, Medulla Tetrapanacis 25 parts, Rhizoma Smilacis Glabrae 10 parts, Herba Kummerowiae Striatae 10 parts, Herba Hyperici Japonici 8 parts, Herba Pteridis Multifidae 20 parts, Radix Isatidis 15 parts, Radix Gentianae 20 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Cyperi 8 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 30 parts, Folium Mori, Spica Prunellae 5 parts, Flos Chrysanthemi 8 parts, 10 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 10 parts, Flos Rosae Rugosae 20 parts, Caulis Bambusae In Taenia 20 parts, Herba Taraxaci 10 parts, Radix Isatidis 20 parts, Folium Perillae 10 parts, Rhizoma Coptidis 8 parts, Herba Sedi 3 parts.

Preferably: be made up of the crude drug of following weight portion: Herba Lophatheri 30 parts, Medulla Tetrapanacis 20 parts, Rhizoma Smilacis Glabrae 15 parts, Herba Kummerowiae Striatae 15 parts, Herba Hyperici Japonici 10 parts, Herba Pteridis Multifidae 10 parts, Radix Isatidis 8 parts, Radix Gentianae 30 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Cyperi 20 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, 10 parts, Folium Mori, Spica Prunellae 15 parts, Flos Chrysanthemi 15 parts, 5 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 8 parts, Flos Rosae Rugosae 10 parts, Caulis Bambusae In Taenia 25 parts, Herba Taraxaci 20 parts, Radix Isatidis 10 parts, Folium Perillae 20 parts, Rhizoma Coptidis 3 parts, Herba Sedi 1 part.

Preferably: be made up of the crude drug of following weight portion: Herba Lophatheri 25 parts, Medulla Tetrapanacis 20 parts, Rhizoma Smilacis Glabrae 10 parts, Herba Kummerowiae Striatae 10 parts, Herba Hyperici Japonici 8 parts, Herba Pteridis Multifidae 15 parts, Radix Isatidis 8 parts, Radix Gentianae 25 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi 10 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 20 parts, Folium Mori, Spica Prunellae 10 parts, Flos Chrysanthemi 10 parts, 5 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 8 parts, Flos Rosae Rugosae 15 parts, Caulis Bambusae In Taenia 20 parts, Herba Taraxaci 15 parts, Radix Isatidis 15 parts, Folium Perillae 15 parts, Rhizoma Coptidis 5 parts, Herba Sedi 2 parts.

The present invention also provides the method for the Chinese medicine composition preparing above-mentioned treatment chronic cholecystitis, comprises the following steps:

First with cold water by herbal medicine immersion 30 minutes, then decoct 25-30 minute, the water yield exceeded 2-3 centimetre after there be not medicine; Stand-by after first pass medical filtration; Added water by the medicinal residues of first pass medicinal liquid, the water yield exceeded 2-3 centimetre after there be not medicine, decocted 25-30 minute, mixed after filtering with first pass medicinal liquid.

In prescription of the present invention, effective ingredient contained by medicine and main component physicochemical property are summarized as follows:

Herba Lophatheri clearing heat and relieving fidgetness, diuresis.Stem, leaf are containing triterpenoid: arundoin, Cylindrin, taraxerol and freidelin.Another meaning aerial parts is containing phenolic constituent, aminoacid, organic acid, saccharide.

Medulla Tetrapanacis clearing away heat and promoting diuresis.Containing ash 5.95% in pith, fat 1.07%, protein 1.11%, crude fibre 48.73%, pentosan 5% and alduronic acid 28.04%, the sodium hydroxide extraction thing of its polysaccharide obtains α-galactose (galactose) through hydrolysis, glucose (glucose) and xylose (xylose), then obtains galacturonic acid after the extract extracted hydrolysis with ammonium oxalate; Also containing 18 kinds of trace element such as 13 seed amino acids and calcium, barium, magnesium, ferrum such as aspartic acid, threonine, companion's propylhomoserin, phenylalanine; Woody part is containing lignin.Leaf containing rice-paper plant Saponin L-II a, L-II b, L-II c, L-II d (papyriosideL-II a, L-II b, L-II c, L-II d), wherein L-II a is the rear production thing of L-II c, and L-II b also may be the rear production thing of L-II d, also containing papyriogenin A-J (paryriogeninA-J), and former papyriogenin A1, A2 (propapyriogeninA1, A2) and quercitrin (quercitrin).

Rhizoma Smilacis Glabrae heat-clearing and toxic substances removing, eliminating dampness and dredging channels.Rhizome is containing Saponin, tannin, resin etc.The root of congener Smilaxpseudo mono-china is containing alkaloid, volatile oil, hexose, tannin, plant sterol and linoleic acid, oleic acid etc.Rhizome is containing smilax saponin class (smilaxsaponins), and wherein one is known as diosgenin (diosgenin) and forms with 1 molecule glucose, 2 molecule rhamnose; Ruscogenin still has tigogenin.Another containing Astilbin, Isoengelitin, succinic acid, daucosterol, Palmic acid, cupreol, and alkaloid, volatile oil, sugar, tannin, resin, sterol, starch etc.

Herba Kummerowiae Striatae clearing away heat-damp and promoting diuresis, spleen invigorating, lung heat clearing diuresis.Herba Hyperici Japonici clearing away heat-damp and promoting diuresis; Removing toxic substances; Dissipating blood stasis for subsidence of swelling.Chemical composition of Chinese materia medica Herba Hyperici Japonici Herba Hyperici Japonici herb is containing embelin (embelin), Herba Ardisiae Japonicae quinone (rapainone), triacontanol (triacontanol) and 2, 5-dihydroxy 3-alkylbenzene quinones (3-alkylderiva-tivesof2, 5-dihyroxybenzoquinone) derivant, also containing trifolin (tri-forlin), hyperin (hyperin), isorhamnetin-3-galactoside (isorhamnetin-3-galactoside), globulariacitrin (rutin), Quercetin-3-rhamanopyranosyl (1 → 2) galactoside (quercetin-3-rhamnosyl (1 → 2) galactoside], isorhamnetin-3-stings sophoriobioside (isorhamnetin-3-robinobioside), Mauritius's Herba lysimachiae capillipedis element (mauritianin) and two kinds of neoflavone alcohol glycosides, i.e. Quercetin-3-(2, 6-bis-rhamnopyranosyl pyrans feeds galactoside) [quercetin-3-(2, 6-dirhamnopyranosylgalactopyranoside)] and isorhamnetin-3-(2, 6-bis-rhamnopyranosyl galactopyranosyl glucoside [isorhamnetin-3-(2, 6-dirhamnopyranosylgalactopyranoside)].Containing quercitrin (quercitrin), Isoquercitrin (isoquercitrin), Quercetin-7-rhamnoside (quercetin-7-rhamnoside), 3, 5, 7, 3 ＇, 4 ＇-pentahydroxyflavone-7-rhamnoside (3, 5, 7, 3 ＇, 4 ＇-pentahydroxyflavone-7-rhamnoside), Herba Hyperici Japonici spirit element (sarothralin) Herba Hyperici Japonici rib element (sarothralen) A, B, uliginosin B (uliginosinB), Filixic Acids BBB (filixicacidBBB, i.e. Filixic Acids), two dehydrogenation GB1a (bisdehydroGB1a), Herba Hyperici Japonici pannol (saroaspiden) A, B, C, albaspidin iBiB (albaspidiniBiB), the plain G of Herba Hyperici Japonici spirit, Herba Hyperici Japonici element (japonicine) A, B, C, D.

Herba Pteridis Multifidae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Radix Gentianae heat clearing and damp drying, pathogenic fire purging is calmed the frightened.

Radix Isatidis heat-clearing and toxic substances removing, Isatis indigotica Fort. root is containing indigo (indigotin, indigo), indirubin (indirubin), Anthraquinones, cupreol (β-sitosterol), clionasterol (γ-sitosterol) and several amino acids: arginine (arginine), glutamic acid (glutamicacid), tyrosine (tyrosine), proline (proline), valine (valine), γ-aminobutyric acid (γ-aminobu-tyricacid).Also containing potassium myronate (sinigrin), indigo glycoside (indoxyl-β-hlucoside), couroupitine A (trptanthrin), 1-Hydrogen thiocyanate-2-hydroxyl fourth-3-alkene (l-thiocyano-2-hydroxy-3-butene), Yichun (epigoitrin) accused by table, gland glycoside (adenosine), Palmic acid (palmiticacid), sucrose (sucrose) and containing 12% amino acid whose proteoglycan.Also contain antibacterial substance and the kinetin of resisting gram-positive and negative bacteria.

Radix Gentianae heat clearing and damp drying; Eliminating pathogen in the liver is calmed the frightened.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear swells; Hypochondriac pain bitter taste; Calentura convulsion with spasms.Containing gentiopicrin (Gentiopicrin), swertiamarin (Swertiamarin), sweroside (Sweroside), trilobatin (Trifloroside), amarogentin (Amarogentin), gentiopicroside tetraacetate (Gentiopicrosidetetraacetate), amaroswerin (Amaroswerin); Gentioflavine (Gentioflavine), erythricine (Gentianine), gentianidine (Gentianidine), gentianol (Gentianol), gentianose (Gentianose), cupreol (β-Sitosterol) etc.

The Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving.Paeoniflorin, paeonol, paeoniflorin, still containing benzoic acid, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes etc.

Rhizoma Cyperi is regulated the flow of vital energy resolving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia.Containing glucose, fructose, starch, volatile oil.Rhizoma Cyperi alkene (Cyperene) is mainly in volatile oil, cyperol (Cy-perol), isocyperol (Isocyperol), and containing nopinene (β-Pi-nene), camphene (Camphene), 1, 8-cineole (1, 8-Cineo-le), limonene (Limonene), selinatriene (Selinatriene), β-selinene (β-Selinene), α-cyperone (α-Cyperone), β-cyperone (β-Cyperone), cyperolone (Cyperolone), rotundone (Rotundone), epoxyguaine azulene ketone (Epoxyguaine), kobusone (Kobusone) and isokobusone (Isokobusone). also containing triterpenes, flavonoid and alkaloid etc.

Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.Rhizome is containing volatile oil, inside there are α-and β-Humuleno (humu-lene), β-elemol (β-elemol), α curcumene (α-curcumene), atractylone (α-tractlone), 3 β-acetoxyl group atractylone (3 β-acetoxyatractylone), celery dienone [selina-4 (14), 7 (11)-diene-8-one], eudesmol (eudesmol), Palmic acid (palmiticacid), hinesol (hinesol), β-selinene (β-selinene) etc.Also containing sesquiterpene lactones compound: atractyloide (atractylenolide)-I ,-II ,-III and 8 β-ethyoxyl atractyloide-II (8 β-ethoxyatractylenolide-II).Again containing polyacetylene compound: 14-acetyl group-12-Herba Senecionis Scandentis acyl group-8-cis reefing triol (14-acetyl-12-senecioyl-2E, 8Z, 10E-atracetylentriol), the trans Rhizoma Atractylodis Macrocephalae triol of each inner smooth acyl group-8-of 14-acetyl group (14-acetyl-12-senecioyl-2E, 8E, 10E-atractylentriol), 12-Herba Senecionis Scandentis light acyl group-8-cis Rhizoma Atractylodis Macrocephalae triol (12-senecioyl-2E, 8Z, 10E-atracetylentriol), the trans Rhizoma Atractylodis Macrocephalae triol of 12-Herba Senecionis Scandentis acyl group-8-(12-senecioyl-2E, 8E, 10E-atractylentriol), 12 Alpha-Methyl bytyry-14-acetyl group-8-cis Rhizoma Atractylodis Macrocephalae triol (12 α-methylbutyryl-14-acetyl-2E, 8Z, 10E-atractylentriol), the trans Rhizoma Atractylodis Macrocephalae triol of 12 Alpha-Methyl bytyry-14-acetyl group-8-(12 α-methylbutyryl-14-acetyl-2E, 8E, 10E-atractylentriol), 14 Alpha-Methyl bytyry-8-cis Rhizoma Atractylodis Macrocephalae triol (14 α-methylbutyryl-2E, 8Z, 10E-atractylentriol), the trans Rhizoma Atractylodis Macrocephalae triol of 14 Alpha-Methyl bytyry-8-(14 α-methylbutyryl-2E, 8E, 10E-atractylentriol).Another containing scopoletin (scopoletin), fructose (fructose), inulin (inulin), the immunocompetent mannan AM-3 of tool, and aspartic acid (asparticacid), serine (serine), glutamic acid (glutamicacid), alanine (alanine), glycine (glycine), valine (valine), isoleucine (isoleucine), leucine (leucine), tyrosine (tyro-sine), phenylalanine (phenylalanine), lysine (lysine), histidine (histi-sine), arginine (arginine), the aminoacid such as proline (proline).

Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.Main component: in Folium Mori, flavone compound accounts for 1% ~ 3% of Folium Mori dry weight is the class plant that in plant kingdom, stem and leaf content is higher.Korea S and Japanese scholars isolate 9 kinds of flavonoid from Folium Mori, mainly the compound such as rutin (rutin), Quercetin, isoquercitrin, Quercetin-3-three glucoside.Alkaloid is the main active of Folium Mori, Japanese scholars Asano etc. (1994) isolate multiple polyhydroxylated alkaloid from Folium Mori, comprise DNJ (1-DNJ), N-methyl isophthalic acid-DNJ (N-Me-DNJ), 2-oxygen-α-D synthesis-1-DNJ, fagomine, 1,4-dideoxy-1,4-imido grpup-D-R alcohol, 1,4-dideoxy-1,4-imido grpup-(2-oxygen-β-D-pyranglucoside)-D-R alcohol and 1 α, 2 β, 7 kinds of alkaloids such as 3 α, 4 β-tetrahydroxy-nor-gelsemium henbane alkane (nor-Daturine).Wherein DNJ (1-DNJ) is in plant kingdom, and only Folium Mori are exclusive.In Folium Mori, content of phytosterol is higher than general plant 3 ~ 4 times.Mainly cupreol (β-sitosterol), stigmasterol (Stigmasterol), campesterol (Camposterol), cupreol β-D-Glucose glycosides (β-sitolsterol β-D-glucoside), Lupeol (lupeol, Lupeol), meso inositol (Myoinositol), molting hormone, inokosterone (Inokosterone), ecdysterone (Ecdysterone) etc.γ-aminobutyric acid (average content is 226mg/100g) abundant in Folium Mori is noticeable, and γ-aminobutyric acid is transformed by glutamic acid, and gamma-glutamic acid content the highest (2323mg/100g) in Folium Mori.Polysaccharides of Folium Mori is rich in, the effect (Chen Fujun etc., 1996) that there is significant blood sugar lowering and suppress blood fat to raise in Folium Mori.

Spica Prunellae clearing away liver-fire, Disperse hepatic depression.The triterpene saponin that it is aglycon that Spica Prunellae and butterfly Spica Prunellae herb contain with oleanolic acid (Oleanolicacid). still containing rutin (Rutin), the glycoside materials such as hyperin (Hyperoside). also containing ursolic acid (Ursolicacid), the organic acid such as caffeic acid (Caffeicacid) and free oleanolic acid. still containing vitamin B1. vitamin C, vitamin K, carotene, resin, amaroid, tannin, volatile oil, the inorganic salt such as alkaloid and potassium chloride. contain the anthocyanin of delphinidin (Delphinidin) and cyanidin (Cyanidin) in spica, d-Camphora (d-Camphor), d-fenchone (d-Fenchone), ursolic acid. fruit ear is containing ursolic acid (ursolicacid) [1, 2], oleanolic acid (oleanolicacid), ursolic acid and oleanolic acid are the Saponin of main glycoside unit, daucosterol (daucosterol), β-Amyrin (β-mayrin) and its lignoceric acid (tetra-cosanicacid), 20 produce alkanoic acid (hexacosanicacid), the ester [2] of octocosoic acid (octa-cosanicacid) and melissic acid (triacontanicacid).Herb is containing acidity many grain Polysaccharides from Prunella vulgaris L (prunellin) [3] of tool anti human immune deficiency virus (HIV), also containing oleanolic acid, ursolic acid, oleanolic acid is the Saponin [4] of glycoside unit, globulariacitrin (rutin), hyperin (hyperoside), caffeic acid (caffeicacid) [5], vitamin (vitamins) C, D, D carotene (carotene), tannin (tan-nin), with thing sense (alkaloids) [6] and volatile oil, wherein containing levo-camphor (camphor), dextrorotation fenchone (fenchone) [7].Aerial parts is containing Coumarins compound (coumarins): umbelliferone (um-bellifrone), east rhinoceros grass element (luteolin), aesculetin (esculetin) [8], flavone compound: luteolin (luteolin), matched moulds orientin (homoorientin) is also known as isorientin (isoorientin), luteolin-7-O-glycoside (cinaro-side) [9], globulariacitrin, gold ratio Fructus Persicae glycoside, Isoquercitrin (isoquercitrin) [10].Inflorescence contains the glucoside [5] of delphinidin (delphinidin) and cyanidin (cynidin), primulagenin-3,5-diglucoside (hirsutidin-, 5-diglucoside), Quercetin (quercitin), nimbecetin (kaempferol) [11] and volatile oil, wherein revolve fenchone [7] containing gum camphor and stone.Leaf is containing multiple fatty acid: oleic acid (oleicacid), linolenic acid (linolenicacid), myristic acid (myristicacid), Palmic acid (palmiticacid), stearic acid (steraricacid) and the moon hang acid (lauricacid) [12].

Flos Chrysanthemi, flower is containing volatile oil, and composition is mainly Borneolum Syntheticum (Borneol), Camphora (Camphor), chrysanthenone (Chrysanthenone).Also containing luteolin-7 glycoside (Luteolin-7-glucoside), cosmosiin (Cosmosiin) is i.e. apigenin-7-O-glycoside (Apigenin-7-O-glucoside), acaciin (Acacetin-7-Orhamnoglucoside), apigenin (Apigenin), apigenin-7-O-Fructus rhamni (Rhamnus davurica Pall.) glycoside (Apigenin-7-O-rhamnoglucoside), acacetin-7-O-glycoside (Acacetin-7-O-glucoside) Quercetin-3-O-galactoside (Isorhamnetin-3-O-galactoside), luteolin-7-O-Fructus rhamni (Rhamnus davurica Pall.) glycoside (Luteolin-7-O-galactoside), luteolin-7-O-Fructus rhamni (Rhamnus davurica Pall.) glycoside (Luteolin-7-O-rhamnogside), luteolin (Luteolin), beta-elemene (β-Elemene), thymol (Thymol), heneicosane (Heneicosane), tricosane (Tricosa-ne), hexacosane (Hexacosane), saccharide and aminoacid.

The pain relieving of Rhizoma Curcumae Longae blood-activating and qi-promoting, wind-damp dispelling profit numbness.Rhizome is containing curcumin chemical compounds: curcumin (curcumin), right, p-dihydroxy two cinnamyl methane (p, p-dihydroxydicinnamoylmethane), i.e. bisdemethoxycurcumin (bisdemethoxycurcumin), p-hydroxyl cinnamyl Resina Ferulae sulfonyl methane (p-hydroxycinnamoylferuloylmethane), i.e. demethoxycurcumin (demethoxycurcumin), dihydro curcumin (dihydrocurcumin), sesquiterpenoids: the new ketone of Rhizoma Curcumae Longae (curlone), Rhizoma Curcumae Longae keto-alcohol (turmeronol) A, B, Germacrone-13 aldehyde (germacrone-13-al), 4-hydroxyl Bisabolol-2, 10-diene-9-ketone (4-hydroxybisabola-2, 10-diene-9-one), 4-methoxyl group-5-hydroxyl Bisabolol-2, 10-diene-9-ketone (4-methoxy-5-hydroxybisabola-2, 10-diene-9-one), 2, 5-dihydroxy-Bisabolol-3, 10-diene (2, 5-dihydroxybisabola-3, 10-diene), former curcumadiol (procurcumadiol), cowherb states dicyclo ketenes (curcumenone), dehydrogenation cowherb states diketone (drhydrocurdione), (4S, 5S)-Germacrone-4, 5-epoxide [(4S, 5S)-germacron-4, 5-epoxide], α-turmerone (α-turmerone), Bisabolol curcumol (bisacurone), cowherb states enol (curcumenol), different former cowherb states enol (isoprocurcumenol), cowherb states ketone glycol (zedoaronediol) difficult to understand, former cowherb states enol (procurcumenol), show former cowherb and state enol (eiprocurcumenol), 4, 5-dihydroxy-Bisabolol-2, 10-diene (4, 5-dihydroxybisabola-2, 10-diene), acidic polysaccharose: Rhizoma Curcumae Longae polysaccharide (utonan) A, B, C, D.Volatile oil (4.2%), its main component has turmerone, fragrance-turmerone (arturmerone), curcumene (curcumene), Germacrone (germacrone), virtue-fragrant curcumene (ar-curcumene), cineole (cineole), terpinene (terpinene), curcumenol (curcumol), cowherb states furan ketenes (curzerenone), cowherb states diketone (curdione), australene (α-pinene), nopinene (β-pinene), limonene (limonene), linalool (linalool), Flos Caryophylli alkene (caryophyllene), Borneolum Syntheticum (borneol) etc.Also containing campesterol (campesterol), stigmasterol (stigmasterol), cupreol (β-sitosterol), cholesterol (cholesterol), fatty acid and Metal Elements K, sodium, magnesium, calcium, manganese, ferrum, copper, zinc etc., zinc/copper=3.7.

The pain relieving of Lignum Dalbergiae Odoriferae blood-activating and qi-promoting.Root heartwood, containing multiple flavones ingredient, belongs to having of isoflavone: formoononetin, Lignum Dalbergiae Odoriferae-medicinal (formononetin), Bao Di xyloquinone (bowdichione), 3'-methoxyl group Dai (3'-methoxydaidzein), belong to having of flavanone: liquiritigenin (liquiritigenin), belong to having of chalcone derivative: Isoliquiritigenin (isoliquiritigenin), 2'-O-methyl Isoliquiritigenin (2'-O-methylisoliquiritigenin), belong to having of isoflavan: (3R)-donkey food grass phenol [(3R)-vestitol] (3R)-ring crack bean quinone [(3R)-claussequinone], 5'-methoxyl group donkey food grass phenol [(3R)-5'-ethoxyvestitol], 3', 8-dihydroxy donkey food grass phenol [(3R)-3, 8-dihydroxyvestitol], dimpling sword-like leave Sha phenol (mucronulatol) of racemization, sword-like leave Sha of dextrorotation belongs to isoflavan (duartin), different sword-like leave Sha of racemization belongs to isoflavan (isoduartin), the different yellow alkene of Lignum Dalbergiae Odoriferae (odoriflavene (, belong to having of isoflavanone: (3R)-2', 3'-7-trihydroxy-4'-methoxyl group isoflavanone [(3R)-2', 3' ,-7-trihydroxy-4'-methoxylsoflavanone).

Flos Rosae Rugosae blood circulation promoting and blood stasis dispelling.Caulis Bambusae In Taenia, clearing away heat to stop vomiting, clearing away phlegm dissipating depression of QI.The Caulis Bambusae In Taenia of phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle contains the inhibiting composition of cAMP phosphodiesterase: 2,5-dimethoxy-p-hydroxybenzaldehyde, syringic aldehyde, coniferyl aldehyde.Another containing p-phthalic acid 2'-hydroxyethyl methyl ester.

Herba Taraxaci, containing taraxasterol (Taraxasterol), choline (Choline), inulin (Inulin), pectin (Pectin); Taraxol (Taraxol), stigmasterol (Stigmasterol), β-Amyrin (β-Amyrin), cupreol (β-Sitosterol), taraxerol (taraxerol), taraxacin (Taraxacerin), taraxacin (Taraxacin) and vitamin A, B, C etc.

Folium Perillae, loose exterior cold, diaphoresis power is stronger.Folium Perillae at Chinese conventional Chinese medicine, and Japanese be used for cooking, be especially absolutely necessary when eating raw fish accompaniment, in Chinese minority area also useful it do vegetable or enter tea.Folium Perillae is also Folium Perillae, has the function of the cold expelling that induces sweat, relieving QI stagnancy in the stomach, cures mainly anemofrigid cold, cough, distension and fullness of the chest and abdomen, the diseases such as nausea and vomiting.Seed also claims Fructus Perillae, the function of have antitussive and antiasthmatic, eliminating the phlegm.

Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.Rhizoma Coptidis rhizome is containing multiple alkaloid, mainly berberine, 5% ~ 8% is about also known as berberine (Berberine), secondly be coptisine (Coptisine), 13-methyl-.psi.-coptisine. (Worenine), palmatine (palmatine, Palmatine), jateorhizine (Jatrorrhizine), Columbamine (Columbamine). still containing obacunone (Obakunone), obakulactone (Obakulactone), magnoflorine (Magnoflorine), ferulic acid (Ferulicacid) etc. leaf is containing berberine 1.4% ~ 2.8%. in addition, in Rhizoma Coptidis also containing various trace elements. isolation identification coptisine from Coptis deltoidea C.Y.Cheng et Hsiao, berberine, palmatine and jateorhizine.

Herba Sedi heat-clearing and toxic substances removing, subduing inflammation.In recent years, alone this product treatment infectious hepatitis (comprises acute icterohepatitisshock clinically, acute without icterohepatitis, and chronic persistent hepatitis, the active stage of chronic hepatitis), reduction serum is turned to ammonia Enzyme and has certain effect, and the bitter taste of patient can be made, have no appetite, the damp and hot symptom such as yellowish or reddish urine alleviates or eliminates.

Chinese medicine composition of the present invention has obvious antiinflammatory action, analgesic activity and choleretic effect.

Detailed description of the invention

Embodiment 1

Chinese medicine composition is made up of the crude drug of following weight portion: Herba Lophatheri 20 parts, Medulla Tetrapanacis 25 parts, Rhizoma Smilacis Glabrae 10 parts, Herba Kummerowiae Striatae 10 parts, Herba Hyperici Japonici 8 parts, Herba Pteridis Multifidae 20 parts, Radix Isatidis 15 parts, Radix Gentianae 20 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Cyperi 8 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 30 parts, Folium Mori, Spica Prunellae 5 parts, Flos Chrysanthemi 8 parts, 10 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 10 parts, Flos Rosae Rugosae 20 parts, Caulis Bambusae In Taenia 20 parts, Herba Taraxaci 10 parts, Radix Isatidis 20 parts, Folium Perillae 10 parts, Rhizoma Coptidis 8 parts, Herba Sedi 3 parts.

First with cold water by herbal medicine immersion 30 minutes, then decoct 30 minutes, the water yield exceeded 2-3 centimetre after there be not medicine; Stand-by after first pass medical filtration; Added water by the medicinal residues of first pass medicinal liquid, the water yield exceeded 2-3 centimetre after there be not medicine, decocted 30 minutes, mixed after filtering with first pass medicinal liquid.

Embodiment 2

Chinese medicine composition is made up of the crude drug of following weight portion: Herba Lophatheri 30 parts, Medulla Tetrapanacis 20 parts, Rhizoma Smilacis Glabrae 15 parts, Herba Kummerowiae Striatae 15 parts, Herba Hyperici Japonici 10 parts, Herba Pteridis Multifidae 10 parts, Radix Isatidis 8 parts, Radix Gentianae 30 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Cyperi 20 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, 10 parts, Folium Mori, Spica Prunellae 15 parts, Flos Chrysanthemi 15 parts, 5 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 8 parts, Flos Rosae Rugosae 10 parts, Caulis Bambusae In Taenia 25 parts, Herba Taraxaci 20 parts, Radix Isatidis 10 parts, Folium Perillae 20 parts, Rhizoma Coptidis 3 parts, Herba Sedi 1 part.

Embodiment 3

Chinese medicine composition is made up of the crude drug of following weight portion: Herba Lophatheri 25 parts, Medulla Tetrapanacis 20 parts, Rhizoma Smilacis Glabrae 10 parts, Herba Kummerowiae Striatae 10 parts, Herba Hyperici Japonici 8 parts, Herba Pteridis Multifidae 15 parts, Radix Isatidis 8 parts, Radix Gentianae 25 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi 10 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 20 parts, Folium Mori, Spica Prunellae 10 parts, Flos Chrysanthemi 10 parts, 5 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 8 parts, Flos Rosae Rugosae 15 parts, Caulis Bambusae In Taenia 20 parts, Herba Taraxaci 15 parts, Radix Isatidis 15 parts, Folium Perillae 15 parts, Rhizoma Coptidis 5 parts, Herba Sedi 2 parts.

First with cold water by herbal medicine immersion 30 minutes, then decoct 25 minutes, the water yield exceeded 2-3 centimetre after there be not medicine; Stand-by after first pass medical filtration; Added water by the medicinal residues of first pass medicinal liquid, the water yield exceeded 2-3 centimetre after there be not medicine, decocted 25 minutes, mixed after filtering with first pass medicinal liquid.

Clinical practice:

1. clinical data

Choose 100 outpatient services and inpatient clinically, the age is selected from 35-65 year, and stochastic averagina is divided into two groups, and one group is matched group, and one group is experimental group.

The matched group commercially available on the market XIAOYAN LIDAN PIAN medicine as contrast, 3 times on the one, one time 6; Medicine prepared by experimental group the present embodiment 1 is treated, every day one pair, sooner or later takes at twice, 14 days 1 courses for the treatment of.

2. efficacy assessment standard

Take a turn for the better: sings and symptoms all alleviates, and ultrasound diagnosis result has clear improvement;

Invalid: symptom, sign, ultrasound diagnosis are all not improved.

3. therapeutic outcome

Matched group XIAOYAN LIDAN PIAN is as the medicine for the treatment of cholecystitis, and its improvement rate is 92%; The medicine prepared with the present embodiment 1 of experimental group is as the medicine for the treatment of cholecystitis, and its improvement rate reaches 96%, has the effect of significant treatment cholecystitis.Pure Chinese crude drug of the present invention boils, non-evident effect, can long-term taking, can as the active drug for the treatment of cholecystitis.

Model case:

Patient female, 52 years old, be admitted to hospital January because the right epigastric discomfort companion of discontinuity is off one's feed, B ultrasonic showed cholecystitis, gallbladder Calculus.Common bile duct is without broadening, and patient shows without jaundice, and liver function chemical examination bilirubin is normal, and transaminase's compared with normal is slightly high.Use Drug therapy prepared by the present embodiment 1, every day one pair, sooner or later take at twice, 14 days 1 courses for the treatment of, after 1 course for the treatment of, the state of an illness take a favorable turn, and fully recovers after 2 courses for the treatment of.

Patient female, 62 years old, stomachache, Nausea and vomiting 3 days, increased the weight of to go to a doctor for one day.Do not enter diet.Stool is normal, and urine is not separated.Have a medical check-up: mind is clear, spirit is poor, anemia looks, and two pulmonary respiration sound is slightly thick, and do not hear and dry, moist rale, expiratory duration extends, heart rate 102 times, and rule is neat.Full abdomen is put down soft, epigastrium tenderness, rebound tenderness (especially with obvious under xiphoid-process), and murphy sign is positive, hepatic region is slight percussion pain, shifting dullness feminine gender.All the other no abnormality seens of having a medical check-up.Use Drug therapy prepared by the present embodiment 2, every day one pair, sooner or later take at twice, 14 days 1 courses for the treatment of, after 1 course for the treatment of, the state of an illness take a favorable turn, and fully recovers after 3 courses for the treatment of.

Claims

1. treat the Chinese medicine composition of chronic cholecystitis for one kind, it is characterized in that, it is be made up of the crude drug of following weight portion: Herba Lophatheri 20-30 part, Medulla Tetrapanacis 20-25 part, Rhizoma Smilacis Glabrae 10-15 part, Herba Kummerowiae Striatae 10-15 part, Herba Hyperici Japonici 8-10 part, Herba Pteridis Multifidae 10-20 part, Radix Isatidis 8-15 part, Radix Gentianae 20-30 part, Radix Paeoniae Alba 10-20 part, Rhizoma Cyperi 8-20 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Folium Mori 10-30 part, Spica Prunellae 5-15 part, Flos Chrysanthemi 8-15 part, Rhizoma Curcumae Longae 5-10 part, Lignum Dalbergiae Odoriferae 8-10 part, Flos Rosae Rugosae 10-20 part, Caulis Bambusae In Taenia 20-25 part, Herba Taraxaci 10-20 part, Radix Isatidis 10-20 part, Folium Perillae 10-20 part, Rhizoma Coptidis 3-8 part, Herba Sedi 1-3 part.

2. kind according to claim 1 treats the Chinese medicine composition of chronic cholecystitis, it is characterized in that: be made up of the crude drug of following weight portion: Herba Lophatheri 20 parts, Medulla Tetrapanacis 25 parts, Rhizoma Smilacis Glabrae 10 parts, Herba Kummerowiae Striatae 10 parts, Herba Hyperici Japonici 8 parts, Herba Pteridis Multifidae 20 parts, Radix Isatidis 15 parts, Radix Gentianae 20 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Cyperi 8 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 30 parts, Folium Mori, Spica Prunellae 5 parts, Flos Chrysanthemi 8 parts, 10 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 10 parts, Flos Rosae Rugosae 20 parts, Caulis Bambusae In Taenia 20 parts, Herba Taraxaci 10 parts, Radix Isatidis 20 parts, Folium Perillae 10 parts, Rhizoma Coptidis 8 parts, Herba Sedi 3 parts.

3. kind according to claim 1 treats the Chinese medicine composition of chronic cholecystitis, it is characterized in that: be made up of the crude drug of following weight portion: Herba Lophatheri 30 parts, Medulla Tetrapanacis 20 parts, Rhizoma Smilacis Glabrae 15 parts, Herba Kummerowiae Striatae 15 parts, Herba Hyperici Japonici 10 parts, Herba Pteridis Multifidae 10 parts, Radix Isatidis 8 parts, Radix Gentianae 30 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Cyperi 20 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, 10 parts, Folium Mori, Spica Prunellae 15 parts, Flos Chrysanthemi 15 parts, 5 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 8 parts, Flos Rosae Rugosae 10 parts, Caulis Bambusae In Taenia 25 parts, Herba Taraxaci 20 parts, Radix Isatidis 10 parts, Folium Perillae 20 parts, Rhizoma Coptidis 3 parts, Herba Sedi 1 part.

4. kind according to claim 1 treats the Chinese medicine composition of chronic cholecystitis, it is characterized in that: be made up of the crude drug of following weight portion: Herba Lophatheri 25 parts, Medulla Tetrapanacis 20 parts, Rhizoma Smilacis Glabrae 10 parts, Herba Kummerowiae Striatae 10 parts, Herba Hyperici Japonici 8 parts, Herba Pteridis Multifidae 15 parts, Radix Isatidis 8 parts, Radix Gentianae 25 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi 10 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 20 parts, Folium Mori, Spica Prunellae 10 parts, Flos Chrysanthemi 10 parts, 5 parts, Rhizoma Curcumae Longae, Lignum Dalbergiae Odoriferae 8 parts, Flos Rosae Rugosae 15 parts, Caulis Bambusae In Taenia 20 parts, Herba Taraxaci 15 parts, Radix Isatidis 15 parts, Folium Perillae 15 parts, Rhizoma Coptidis 5 parts, Herba Sedi 2 parts.

5. preparation is as claimed in claim 1 plants the method for the treatment of the Chinese medicine composition of chronic cholecystitis, it is characterized in that, comprises the following steps: