CN101816771B - Chinese medicinal composition for treating epilepsy disease and preparation method thereof - Google Patents
Chinese medicinal composition for treating epilepsy disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating epilepsy disease and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: cinnabar, magnetite, dragon bone, amber, oyster shell, spina date seed, platycladi seed, silktree albizzia bark, sea-ear shell, nacre, red ochre, tribulus terrestris, cornu saigae tatariace powder, tall gastrodia tuber, radix pseudo-ginseng, gambir plant, white muscardine silkworm, scorpion, grassleaf sweelflag rhizome, fritillaria, benzoin, radix rehmanniae preparata, mongolian snakegourd root, lightyellow sophora root, Chinese eaglewood and the like. The Chinese medicinal composition can be prepared into any one common orally-taken preparation by a conventional Chinese medicinal preparation method. The Chinese medicinal composition can remarkably improve the symptoms: deprementia, silence and dementia, allophemy, sudden faint, unconsciousness, foam at the mouth, tic of limbs caused by epilepsy disease and the like, and has the advantages of extract clinical treatment effect, remarkable treatment effect and quick response. The Chinese medicinal composition also has the advantages of low cost, basically no toxic or side effect and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of epileptics.Relating in particular to a kind of is the Chinese medicine composition and preparation method thereof of the treatment epileptics of crude drug with the Chinese herbal medicine.
Background technology
Epilepsy is a kind of disease and syndrome, is feature with the intermittent central nervous system function imbalance due to the unexpected repeatedly over-discharge of brain neuroblastoma unit.Be a kind of brain that originates from, and sensation of movement, autonomic nerve, consciousness and the mental status obstacle in various degree that shows effect repeatedly.Epilepsy has complexity, and its basic feature is a repeatability and ictal.Doctor trained in Western medicine is divided into idiopathy and Secondary cases (symptomatic) epilepsy two big classes according to epileptics because of difference.The former and inherited genetic factors have than confidential relation, the latter is because of decreasing and dysbolismus in multiple brain is sick, as congenital diseases, antenatal period and perinatal disease (maternal infuries be the infancy stage epilepsy commonly encountered diseases because of), something lost, wound, infection, poisoning, intracranial tumor, cerebrovascular disease, Nutrition and Metabolism disease etc. after the hyperpyrexia convulsion.The traditional Chinese medical science thinks that epilepsy belongs to phlegm syndrome, and dispirited key closes and is its pathologic basis.Cause epilepsy syndrome, or because of congenital factors, or because of turbid interior the giving birth to of expectorant, or because of incoordination of seven emotions.
The traditional Chinese medical science is called epilepsy syndrome or epilepsy disease to epilepsy traditionally, and epilepsy is a call afterwards.On the early stage medical book, cure tame many insane, mad, epilepsy are mixed and claim, do not mark a clearly demarcated boundary.People recognized gradually afterwards, and insane, mad, epilepsy all belongs to the disease of spirit, mind aspect, and the three respectively has its notable attribute again.Insane and madly mainly show as mental disorder,, affective disorder not normal to move, hallucination illusion, consciousness disorder are basic feature.In the ancient books many divide with the negative and positive difference insane and mad, spirit depressing, the dementia of mourning in silence, the speaking incoherently person belongs to the moon, is epilepsy; Spirit is excited, manic fiery and forthright, curses and beats saboteur and belongs to sun, is mad disease.Epilepsy then mainly shows as Mental Subnormality in various degree, and severe patient one outbreak will suddenly be fainted, and is unconscious, slobbering, and tic of the limbs, outbreak is as good as with the normal person again later.
Epilepsy is a kind of common nervous system disease, the incidence rate of each type of showing effect is different with the age, and just sent out the age 60%～80% before 20 years old, if can not get effective treatment, the epileptic of considerable part can not work or work, some patients also will work the mischief to society because of epilepsy causes dystropy.According to investigations, existing at present 9,000,000 epileptics of China.In recent years, because the influence of multiple complexity factor, the clinical onset rate is also on the rise.
Modern medicine is at clinical a certain symptom treatment, often fall flat, can not find suitable Therapeutic Method, in order to overcome above-mentioned defective, the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment epilepsy, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical accent, emergency is taken in concurrently, filter out the natural plant of the eliminating phlegm of having one's ideas straightened out, suppressing the hyperactive liver to relieve the wind syndrome, heat-clearing and toxic substances removing,, be prepared from according to certain weight proportion according to the theory of Chinese medical science prescription.A kind of Chinese medicine composition of evident in efficacy, with low cost, treatment epilepsy that toxic and side effects is minimum is provided.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be: pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention is assorted to overcome above-described shortcoming, and a kind of Chinese medicine composition of treatment epileptics of evident in efficacy, with low cost, almost non-toxic side effect is provided.
The technical problem of the desired solution of the present invention realizes by following technological approaches.
A kind of Chinese medicine composition for the treatment of epileptics of the present invention, the component of main following weight portion is formed:
1～50 part in Cinnabaris, 1～50 part of Magnetitum, 1～100 part of Os Draconis, 1～50 part of succinum, 1～100 part of Concha Ostreae, 1～100 part of Semen Ziziphi Spinosae, 1～100 part of Semen Platycladi, 1～100 part of Cortex Albiziae, 1～120 part of Concha Haliotidis, 1～100 part of Concha Margaritifera, 1～50 part of Haematitum, 1～50 part of Fructus Tribuli, 1～50 part of cornu saigae tatariace powder, 1～100 part in Rhizoma Gastrodiae, 1～120 part of Radix Notoginseng, 1～100 part of Ramulus Uncariae Cum Uncis, 1～50 part of Pheretima, 1～50 part of Bombyx Batryticatus, 1～50 part of Scorpio, 1～150 part of Rhizoma Acori Graminei, 1～120 part of Styrax, 1～50 part of Bulbus Fritillariae Uninbracteatae, 1～100 part of Semen Trichosanthis, 1～120 part of Radix Rehmanniae Preparata, 1～120 part of Radix Trichosanthis, 1～120 part of Radix Angelicae Sinensis, 1～120 part of the Radix Paeoniae Alba, 1～100 part of Fructus Ligustri Lucidi, 1～100 part of Fructus Lycii, 1～30 part of Herba Menthae, 1～50 part of Bulbus Lilii, 1～120 part of Radix Adenophorae (Radix Glehniae), 1～50 part of Herba Dendrobii, 1～50 part of Rhizoma Polygonati Odorati, 1～120 part of Rhizoma Imperatae, 1～100 part of Radix Scrophulariae, 1～150 part of Pericarpium Citri Reticulatae, 1～150 part of Fructus Aurantii Immaturus, 1～150 part of Fructus Toosendan, 1～100 part of Radix Curcumae, 1～100 part of Rhizoma Chuanxiong, 1～100 part of Lignum Aquilariae Resinatum, 1～50 part of Rhizoma Atractylodis, 1～100 part of Fructus Amomi.
Be preferably:
15 parts in Cinnabaris, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis.
The weight portion consumption of each component of Chinese medicine composition of the present invention can also be:
1～50 part of Camphora, 1～50 part of Borneolum Syntheticum, 1～120 part of Benzoinum, 1～120 part of Herba Lysimachiae foenum-graeci, 1～100 part of Radix Rehmanniae, 1～120 part of Radix Polygoni Multiflori, 1～150 part in Poria, 1～100 part in Talcum, 1～100 part of Flos Lonicerae, 1～100 part of Herba Taraxaci, 1～120 part of Cortex Moutan, 1～100 part of Radix Sophorae Flavescentis, 1～120 part of the Radix Linderae, 1～100 part of Radix Arnebiae (Radix Lithospermi), 1～100 part of Herba Violae, 1～50 part of Cornu Bubali, 1～50 part of Rhizoma Picrorhizae, 1～50 part of Radix Stellariae, 1～120 part of Radix Saposhnikoviae, 1～50 part of Herba Schizonepetae, 1～100 part of Rhizoma Et Radix Notopterygii, 1～100 part of Radix Bupleuri.
Be preferably:
10 parts of Camphoras, 10 parts of Borneolum Syntheticums, 30 parts of Benzoinumes, 30 parts of Herba Lysimachiae foenum-graeci, 20 parts of Radix Rehmanniae, 30 parts of Radix Polygoni Multiflori, 30 parts in Poria, 30 parts in Talcum, 20 parts of Flos Loniceraes, 30 parts of Herba Taraxacis, 30 parts of Cortex Moutans, 20 parts of Radix Sophorae Flavescentiss, 30 parts of the Radixs Linderae, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Violaes, 15 parts of Cornu Bubalis, 25 parts of Rhizoma Picrorhizae, 20 parts of Radix Stellariaes, 30 parts of Radix Saposhnikoviaes, 15 parts of Herba Schizonepetae, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Bupleuri.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
Chinese medicine composition of the present invention is opened one's minds based on traditional Chinese medical science the five internal organs differentiation of syndromes of YIN and YANG guiding principle, in conjunction with safe one and Pu innovation theory system " ten thousand diseases ascent theory ", " the five internal organs differentiation of syndromes of YIN and YANG guiding principle ", " three-dimensional conservation regulation and control rule " and clinical treatment " pairing principle " are as instructing, take place in conjunction with disease, development and the rule that changes, classify according to the original new drug system, formation is monarch with " the five internal organs basic function is adjusted; equilibrium between yin and yang coordination side ", " the main pathogenesis of the five internal organs adjustment side " is minister, " therapy of serious disease side " is assistant, " clinical fundamental symptoms symptomatic treatment side " Chinese medicine patent medicine " original new drug system " for making.
The used herbal raw material medicine of the present invention all can be buied from the Chinese medicine shop, and its specification meets national medical standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.As guidance: for oral administration: 1) capsule: obey 2～5 every day three times at every turn, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.
The treatment that the present invention is directed to the epileptic is very effective, various crude drug are coordinated mutually can play together and are at utmost brought into play drug effect, can effectively improve the self-coordination ability of patient's body, significantly improve function and clinical subjective symptoms, have advantage such as have no side effect, expense is lower in addition.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never are limited to the present invention.
The preparation of [embodiment 1] capsule
Take by weighing each raw material by following weight portion: 15 parts in Cinnabaris, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis.
Grind into after each component mixing with above-mentioned weight and incapsulate promptly after fine powder is crossed 1500 mesh sieves.
The preparation of [embodiment 2] granule
Take by weighing each raw material by following weight portion: 15 parts in Cinnabaris, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis.
Each raw material of above-mentioned weight fraction is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule.
The preparation of [embodiment 3] tablet
Take by weighing each raw material by following weight portion: 15 parts in Cinnabaris, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis.
Each raw material of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800～1200 order dusting covers, make tablet promptly.
The preparation of [embodiment 4] pill
Take by weighing each raw material by following weight portion: 15 parts in Cinnabaris, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis.
Each raw material of above-mentioned weight is mixed, grind into cross 600～1000 mesh sieves behind the fine powder after, make pill promptly.
The preparation of [embodiment 5] oral liquid
Take by weighing each raw material by following weight portion: 15 parts in Cinnabaris, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis.
Each raw material of above-mentioned weight is mixed, after three decoctions, three filtrates are mixed, filter, be concentrated into
Normal concentration, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is made oral liquid promptly.
[experimental example] traditional Chinese medicine composition for treating epileptic's of the present invention clinical observation on the therapeutic effect experiment
One, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 27 routine patients altogether, wherein male 18 examples, women 9 examples; The oldest person 76 years old, the age reckling has only 11 years old.
Two, Therapeutic Method:
Usage and dosage: adopt the prepared medicament of the embodiment of the invention, its usage and consumption are as follows: 1) capsule: obey 2～5 every day three times at every turn, and every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.
The course of treatment: one month is a course of treatment, treats the course of treatment altogether.
Three, therapeutic evaluation standard
Cure: sign and symptom are improved fully, and life is normal, and is in high spirits.
Produce effects: sign and symptom are significantly improved, and it is normal substantially to live, and spirit is fine.
Effectively: sign and symptom change, and random thoughts have discomfort slightly, but can accept.
Invalid: sign does not have change, symptom such as preceding.
Four, model case:
1, Zhu, man, 19 years old.
The patient goes to a doctor because of " discontinuity convulsive seizure 4 years ".Do not have obvious inducement in the time of 15 years old and convulsive seizure first occurs, show as partial seizures and expand to generalized seizures, lift on the right hand during outbreak, head is rotation to the right, eyes are hung oneself subsequently, watch the place ahead attentively, orthocolosis clonic spasm, gnathospasma, continue to alleviate after several minutes, go to a doctor, be diagnosed as " epilepsy " in local hospital, and it is not good enough to begin to take multiple antiepileptic effect, and seizure frequency is about 15 days for 1 time.Mode of onset changed to some extent afterwards, and the omens such as waiting the gastrointestinal upset sense of feeling sick is arranged before the outbreak, occurred subsequently lifting on the right hand, head is rotation to the right, and of short duration loss of consciousness recovers normal after the lasting several seconds, outbreak is frequent, and outbreak is 1 time about 5 days, no longer expands to the complete tetanus grand mal.The headache sense of discomfort is arranged after the outbreak, can not recall situation at that time, do not have vision, psychological sense of discomfort are arranged, do not have hallucination, do not have the surrounding Jamais Vu, not terrified sense.Past medical histroy: infectious diseases such as have no alternative but to type hepatitis, no history of operation is denied allergies.Its mother did not have strong pregnancy reaction.Personal history: the difficult labour history is arranged during birth, after giving birth to the of short duration history of suffocating is arranged, after rescuing, breathe and recover.The carbon monoxide poisoning history was arranged in the time of 1 year old.Emotional intelligence is grown normal substantially when child and teenager.
Took Chinese medicine composition of the present invention 1 month, sb.'s illness took a favorable turn, and period in a medicine shows effect 4 times altogether, outbreak back no headache sense of discomfort.Continue and obeyed Chinese medicine composition of the present invention 1 month, period in a medicine, patient's petit mal 2 times, and symptom is lighter.Continue and obeyed Chinese medicine composition of the present invention 1 month, patient's epilepsy is not reaccessed.Continue and obeyed Chinese medicine composition of the present invention 2 months, decrement is to drug withdrawal gradually.Drug withdrawal was paid a return visit after 3 years, and patient's epilepsy is not seen outbreak.
2, Lee, woman, 28 years old.
When the patient was educated in the university, tic of the limbs without reason turned on two, spits out white foams, and lasts about 2-3 minute, in the spontaneous remission, outbreak in later every 3-5 days 1 time or 1 day for several times.Be diagnosed as epilepsy grand mal (complete tetanus Myoclonic seizures epilepsy).Successively take multiple antiepileptics such as " stupid appropriate English sodium ", " carbamazepine ", " valpramide ", " clonazepam ", outbreak fails to control fully, and an outbreak in month 3-4 time continues 30 minutes at every turn, and symptom is the same.
Took Chinese medicine composition of the present invention 1 month, patient's mental status takes a turn for the better, and takes medicine one month in, and by outbreak in original month 4 times each lasting 30 minutes, reducing to month 1 persistent period of outbreak was 15 minutes, and sb.'s illness took a favorable turn.Continue and obeyed Chinese medicine composition of the present invention 1 month, period in a medicine, patient's petit mal once tic of the limbs do not occur.The clothes Chinese medicine composition of the present invention 1 month that continues, period in a medicine, the patient occurs epilepsy grand mal suddenly once, but the persistent period only is 5 minutes during outbreak.Continue and obeyed Chinese medicine composition of the present invention 1 month, abnormal conditions do not appear in patient again.Continue and obeyed Chinese medicine composition of the present invention 1 month, decrement is to drug withdrawal gradually.Drug withdrawal is paid a return visit after half a year, and epilepsy does not have recurrence, pays a return visit again after 2 years, and conditions of patients is stable not to be seen and send out.
3, cattle, woman, 16 years old.
The patient because of occurring paroxysmal right side numb limbs and tense tendons after the viral encephalitis, twitched before 3 years.Discontinuity paroxysm right side numb limbs and tense tendons over 3 years is twitched cyanotic lips, purplish tongue.Be diagnosed as localized epilepsy.The commentaries on classics of not getting better of integrative therapy once, the state of an illness, and dull expression appears, insomnia, nervous.
Took Chinese medicine composition of the present invention 1 month, patient right side numb limbs and tense tendons alleviates, and twitches frequency and reduces, and does not have and has palpitation, sleeps and recover normal.Continue and obeyed Chinese medicine composition of the present invention 1 month, patient right side numb limbs and tense tendons disappears, and is flexibly movable, twitches the number of times minimizing, has rosy cheeks, with an easy grace.Continue and obeyed Chinese medicine composition of the present invention 2 months, the patient recovers normally, and limbs do not have numb the twitch, so drug withdrawal.Follow up a case by regular visits to the stable nothing recurrence of conditions of patients in 2 years.
4, Fang, man, 37 years old.
Patient's epilepsy medical history 13 years, grand mal.Psychomotor attack is the complexity epilepsy, and the outbreak cycle is the longest 14 months, and the shortest one month several times.Very the person treated unsatisfactory curative effect through big infirmary is many-sided in one day several times.Take phenytoin sodium, clonazepam for a long time, disease still fails to control.Because patient's course of disease is longer, state of an illness complexity is taken Western medicine in a large number and has been caused very big side effect to patient's body, cures so desire Chinese medicine.
Took Chinese medicine composition of the present invention 1 month, irritated insomnia disappears, and sleeps, and diet is good, and only at a month centre petit mal once, and the persistent period is shorter.Continue and obeyed Chinese medicine composition of the present invention 2 months, patient's mental status takes a turn for the better, and the period in a medicine epilepsy does not have recurrence.Continue treatment 2 months, conditions of patients is steady, drug withdrawal.Pay a return visit after 2 years, patient's epilepsy does not recur.
5, fourth so-and-so, man, 13 years old.
The patient suddenly when walking, stood transfixed to the ground in the time of 5 years old, turned on the eyeball, but only more than ten second time recovers normal again, do not take notice of very much at that time yet, afterwards again continuously several times and also each duration of seizure different prolongations is all arranged, also can urinate wet trousers when showing effect sometimes, at examination in hospital, be diagnosed as epilepsy (petit mal), took the commentaries on classics of slightly getting better of multiple Chinese medicine, Western medicine, but changeable, so far show effect for several times every day, but outbreak is ofer short duration.Inducements such as hyperpyrexia wound did not appear during the patient children.The patient has the epileptics family history.
Took Chinese medicine composition of the present invention 1 month, patient's epilepsy number of times reduces, and the persistent period shortens, and symptom obviously alleviates during epilepsy.Continue and obeyed Chinese medicine composition of the present invention 1 month, epilepsy is only shown effect 7 times between January, and symptom is lighter.Continue and obeyed Chinese medicine composition of the present invention 1 month, epilepsy is only shown effect 3 times between January.Continue and obeyed Chinese medicine composition of the present invention 3 months, according to the drug withdrawal gradually of the epilepsy state of an illness.Pay a return visit after 1 year, epilepsy was never reaccessed, and the state of an illness is more stable.
6, a surname certain, woman, 16 years old.
The patient occurs stopping original action suddenly because of being interrupted, and stares for two, and language interrupted 2 years, increased the weight of surplus prescription on individual diagnosis in 1 month.The patient is frequent of short duration obnubilation to occur, and activity and language interrupt, exhale should, anorexia loose stool at ordinary times, fatigue and weak, lusterless complexion.When the patient examines, have rosy cheeks, nutritious, spirit is not good enough, and it is dull that expression shows, and the family numbers of patients narration is before one day, and the patient just showed effect, and continued nearly 2 minutes.Be diagnosed as petit mal disease.
Took Chinese medicine composition of the present invention 1 month, conditions of patients takes a turn for the better, and attack times reduces, and the persistent period shortens during outbreak.Continue and obeyed Chinese medicine composition of the present invention 2 months, the patient is outbreak once more, and is evident in efficacy.Continue and obeyed Chinese medicine composition of the present invention 1 month, reduce dose, drug withdrawal at the end of month middle of the month gradually.Follow up a case by regular visits to after 1 year, the patient does not see recurrence, and intelligence is also recovered gradually.
7, Liu, man, 46 years old.
The patient twitches surplus prescription on individual diagnosis in 8 years because of paroxysmal left limb numbness.Patient's dim complexion, dull expression, left limb is dumb, self-induction numbness, insomnia, cardiopalmus.Successively take multiple Drug therapy, the state of an illness commentariess on classics of not getting better, and dull expression, insomnia, have palpitation, increase the weight of in recent years.Examine and be stagnation of QI abundant expectoration type epilepsy.
Took Chinese medicine composition of the present invention 1 month, patient's left limb numbness alleviates to some extent, twitches and reduces, insomnia, nervous sx.Continue and obeyed Chinese medicine composition of the present invention 1 month, patient's left limb is numb to disappear, flexibly movable, nothing insomnia, nervous, with an easy grace.Continue and obeyed Chinese medicine composition of the present invention 1 month, the patient recovers normally to have rosy cheeks, and limbs do not have numb the twitch, so drug withdrawal.Follow up a case by regular visits to the stable nothing recurrence of conditions of patients in 2 years.
8, Pan, man, 23 years old.
The patient is interrupted outbreak because of " scream suddenly, twitch " and went to a doctor in 5 years.The patient is the Spring Festival before going to a doctor 5 years, does not have obvious inducement and screams suddenly, falls in a swoon.This kind phenomenon takes place after 3 months once more, and orthocolosis clonicity is simultaneously twitched, and attaches most importance to the right side.Autumn, above-mentioned phenomenon took place again, had occurred gnathospasma again, and cyanotic lips turns on the eyeball, topple over to the left, coolness of extremities, breathe irregular.The no certain rules of showing effect over 5 years, but the length of one's sleep is few, overworks, and generally all can have an attack of one's old illness under the situations such as flu, anger.Hospital diagnosis is " epilepsy ", and it is not good enough once to take multiple antiepileptic effect, and increases the weight of gradually, have an attack of one's old illness frequent gradually over 5 years and increase the weight of, and hypomnesis, it is blunt that reaction has slightly.
Took Chinese medicine composition of the present invention 1 month, all reactions of conditions of patients are good, and epilepsy is not shown effect.Continue and obeyed Chinese medicine composition of the present invention 2 months, period in a medicine is fallen ill once because of disagreeing with the colleague, but symptom is lighter.Continue and obeyed Chinese medicine composition of the present invention 2 months, though work is tired, do not bring out epilepsy, memory, reagency are clearly better before the treatment.Continue and obeyed Chinese medicine composition of the present invention 1 month, reduce dose, drug withdrawal at the end of month middle of the month gradually.No matter pay a return visit after 1 year, do not have an attack of one's old illness over one year once, be not have a rest whole night, still does continuously and also do not bring out than heavy physical labour.
Five, therapeutic outcome:
In the 27 routine cases of being accepted for medical treatment,, wherein cure 9 examples through treatment in 6 months, produce effects 11 examples, effective 4 examples, invalid 3 examples, total effective rate reaches 88%.The result shows that Chinese medicine composition of the present invention has extremely significant curative effect to the treatment epileptic.
Claims (10)
1. Chinese medicinal capsule agent for the treatment of epileptics, it is characterized in that: take by weighing each raw material: 15 parts in Cinnabaris by following weight portion, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis grind into after each component of above-mentioned weight mixed and incapsulate promptly after fine powder is crossed 1500 mesh sieves.
2. Chinese medicine granules for the treatment of epileptics, it is characterized in that: take by weighing each raw material: 15 parts in Cinnabaris by following weight portion, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis, each raw material of above-mentioned weight fraction is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule.
3. Chinese medicinal tablet for the treatment of epileptics, it is characterized in that: take by weighing each raw material: 15 parts in Cinnabaris by following weight portion, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis, each raw material of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800～1200 order dusting covers, make tablet promptly.
4. medicine pill for the treatment of epileptics, it is characterized in that: take by weighing each raw material: 15 parts in Cinnabaris by following weight portion, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis, each raw material of above-mentioned weight is mixed, grind into cross 600～1000 mesh sieves behind the fine powder after, make pill promptly.
5. Chinese medicine oral liquid for the treatment of epileptics, it is characterized in that: take by weighing each raw material: 15 parts in Cinnabaris by following weight portion, 15 parts of Magnetitums, 15 parts of Os Draconis, 15 parts of succinums, 15 parts of Concha Ostreaes, 20 parts of Semen Ziziphi Spinosaes, 20 parts of Semen Platycladi, 30 parts of Cortex Albiziaes, 30 parts of Concha Haliotidis, 10 parts of Concha Margaritiferas, 15 parts of Haematitums, 15 parts of Fructus Tribulis, 10 parts of cornu saigae tatariace powders, 30 parts in Rhizoma Gastrodiae, 30 parts of Radix Notoginseng, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Pheretimas, 15 parts of Bombyx Batryticatus, 15 parts of Scorpios, 50 parts of Rhizoma Acori Graminei, 30 parts of Styrax, 15 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Semen Trichosanthis, 20 parts of Radix Rehmanniae Preparata, 30 parts of Radix Trichosanthis, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lycii, 10 parts of Herba Menthaes, 15 parts of Bulbus Liliies, 30 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Herba Dendrobiis, 15 parts of Rhizoma Polygonati Odorati, 30 parts of Rhizoma Imperataes, 120 parts of Radix Scrophulariaes, 100 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Aurantii Immaturuss, 50 parts of Fructus Toosendans, 30 parts of Radix Curcumaes, 20 parts of Rhizoma Chuanxiongs, 20 parts of Lignum Aquilariae Resinatum, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Amomis, each raw material of above-mentioned weight is mixed, after three decoctions, three filtrates are mixed, filter, be concentrated into normal concentration, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is made oral liquid promptly.
6. the application of the described Chinese medicinal capsule agent of claim 1 in preparation treatment epilepsy medicament.
7. the application of the described Chinese medicine granules of claim 2 in preparation treatment epilepsy medicament.
8. the application of the described Chinese medicinal tablet of claim 3 in preparation treatment epilepsy medicament.
9. the application of the described medicine pill of claim 4 in preparation treatment epilepsy medicament.
10. the application of the described Chinese medicine oral liquid of claim 5 in preparation treatment epilepsy medicament.
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| CN102755592B (en) * | 2012-07-03 | 2013-12-11 | 王伏兰 | Traditional Chinese medicine preparation for treating schizophrenia |
| CN103099858B (en) * | 2013-02-08 | 2014-03-12 | 浙江省中医院 | Traditional Chinese medicine combination and application thereof |
| CN103784920A (en) * | 2014-01-16 | 2014-05-14 | 王秋兰 | Traditional Chinese medicinal composition for rapid treatment of epilepsy |
| CN104001057B (en) * | 2014-06-12 | 2016-07-13 | 青岛大学附属医院 | For treating the heart schizoid medicine of kidney disorder type and preparation method thereof |
| CN106177418A (en) * | 2016-08-28 | 2016-12-07 | 徐锋 | A kind of Chinese medicine formula treating epileptics |
| CN109381488A (en) * | 2018-12-22 | 2019-02-26 | 包桂荣 | The topical agent and preparation method of epileptics |
| CN113288958B (en) * | 2021-05-19 | 2022-08-19 | 成都中医药大学附属医院 | Pharmaceutical composition for treating epilepsy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1094619A (en) * | 1993-04-21 | 1994-11-09 | 苗德君 | The Chinese medicine of treatment epileptics |
| CN1112836A (en) * | 1994-06-30 | 1995-12-06 | 许新升 | Meicinal prepn. "Kexianling" for curing epilepsy |
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| CN1094619A (en) * | 1993-04-21 | 1994-11-09 | 苗德君 | The Chinese medicine of treatment epileptics |
| CN1112836A (en) * | 1994-06-30 | 1995-12-06 | 许新升 | Meicinal prepn. "Kexianling" for curing epilepsy |
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