CN108721551A - A kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and product - Google Patents
A kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and product Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The present invention relates to health product technology field, more particularly to a kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and product.In parts by weight, which is made of the following raw material：10~100 parts of ginseng, 10~100 parts of Radix Paeoniae Alba, 10~100 parts of moutan bark, 10~100 parts of fructus alpiniae oxyphyllae, 10~100 parts of prepared fleece flower root.Present invention discover that the composition has nourishing liver and kidney, adjusting negative and positive, benefiting qi and nourishing blood, harmonizing emotions effect; have the function of protecting autonomic nervous function, can improve pressure leads to the states such as anxiety-depression, absent minded, listless, dispirited, ability of learning and memory decline.Clear efficacy of the present invention has specific aim, and significant effect, using pure natural medical and edible dual purpose plant as raw material, combination is simple, safety and stability, is suitble to take for a long time.
Description
This application claims being submitted on April 14th, 2017, Patent Office of the People's Republic of China, application No. is 201710244073.9, invention names
Referred to as the Chinese patent application of " a kind of the Chinese medicine composition with harmonizing emotions and preparation method thereof and product " is preferential
Power, entire contents are hereby incorporated by reference in the application.
Technical field
The present invention relates to health product technology field, more particularly to it is a kind of have effects that the Chinese medicine composition of harmonizing emotions and its
Preparation method and product.
Background technology
With the development of the social economy, work and life stress gradually increase, the mental healths such as anxiety, depression, insomnia are asked
It inscribes outstanding day by day.Far away from《Interior warp》Period, people just recognize that environmental factor, bad direct stimulation can lead to spirit and body disease
Disease.The feelings will activity of people or daily life against normal manner can directly injure internal organs negative and positive of qi and blood more than human body itself adjustable range and
Morbidity.Disease mainly has the factors such as seven feelings, feeding desorder and work and rest immoderation to cause from interior and give birth to.Chinese medicine thinks that emotional discomfort is strongly fragrant
The main performance of card and the cause of disease of melancholia.《Plain Questions this disease piece》It says：" people's sorrow is pondered over, i.e., sad ".It speaks out《Three because of pole one
It discusses disease side》In point out：" perseverance of seven sweet hearts, that moves is then first from the strongly fragrant hair of internal organs ", he points out initially that seven feelings are the normal essences of people
Refreshing physiological activity, but seven feelings excessively then cause internal organs pent-up, qi-blood-body fluid collection and defeated cloth are abnormal, and induce Emotional disorder.
Liver controlling conveyance and dispersion, harmonizing the functional activities of vital QI, emotion regulation influence if prolonged and repeated direct stimulation is more than body ability to bear
Liver catharsis function, liver lose item up to then stagnation of liver qi.Qi depression transforming into fire, refining Tianjin above disturb clear key, hyperpraxia occur at phlegm, essence
Refreshing depression, memory loss etc..Liver depression forming fire upsets heart arteries and veins, vexed, difficulty falling asleep etc. occurs.Liver depression resolving sputum, convulsive seizure due to phlegm-fire disturb courage, courage
Main " resolution ", therefore slow movement is shown as, the symptoms such as decision-making capability decline.Heart governing blood and vessels and main gods, it is qi and blood that The spleen has the function to transport and transform nutrients
The source of vital function.If psychological pressure is excessive, the impairment of the spleen of worrying beyond measure, The spleen has the function to transport and transform nutrients, the weary source of qi and blood, and body mistake is foster then indigestion and loss of appetite, becomes thin, four
Limb is weak, and dark to consume painstaking effort then deficiency of heart-blood, The heart controls mental activities, and god, which becomes homeless to support, causes palpitation and amnesia, insomnia and dreamful sleep.Kidney yin is whole body yin-fluid
It is basic, yin-fluid has moist quiet effect to human body, can moisten the heart-yin, presses down liver-yang, supplements the substance of organ material base and brain
Strength.If qi depression transforming into fire just injures yin-fluid, must not sun processed, then the moon declines for the overabundance of yang, and the deficiency of Yin Sheng Neire palpitaition occurs to upset the mind
Etc. symptoms.The brain being the reservoir of the marrow, if with the passing of time depressive state is not cured, member god, which loses, to be supported, and marrow metaplasia is insufficient, then " vertigo and tinnitus, shin acid are dizzy
It emits, mesh institute is without seeing, reposal of slacking off "
So far, absent minded for anxiety-depression caused by work and life stress, it is listless, it is dispirited
It is depressed, ability of learning and memory declines etc., doctor trained in Western medicine there is no active drug.Only after above-mentioned symptom is developed to morbid state, there are portions
Divide tranquilizing soporific, antianxiety, antidepressant drug, and is easy to cause the side effects such as after effect, withdrawal reaction, dependence and addiction.
Invention content
In view of this, the present invention provides a kind of Chinese medicine compositions with harmonizing emotions and preparation method thereof and production
Product.The Chinese medicine composition is using pure natural medical and edible dual purpose plant as raw material, safety and stability, has significant harmonizing emotions effect.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
Having effects that the Chinese medicine composition of harmonizing emotions the present invention provides a kind of, in parts by weight, by the following raw material system
At：
10~100 parts of ginseng, 10~100 parts of Radix Paeoniae Alba, 10~100 parts of moutan bark, 10~100 parts of fructus alpiniae oxyphyllae, prepared fleece flower root
10~100 parts.
The composition material of the present invention is medical and edible dual purpose plant.Ginseng is sweet in flavor, slight bitter, warm-natured, flat.Returns spleen, lung, the heart
Through.Have effects that tonifying Qi, prevent prolapse, promotes the production of body fluid, calms the nerves, intelligence development.《This warp》Record ginseng " main tonifying five zang organs, soothe the nerves, stop palpitate with fear,
Remove pathogenic factor, improving eyesight, happy intelligence development.",《Book on Chinese herbal medicine covers bamboo fish trap》：" relieving asthma and cough, unobstructed blood vessels rush down yin fire, nourish Yuanyang.".
Radix Paeoniae Alba is the peeling dry root of ranunculaceae plant Radix Paeoniae Alba, cold nature, bitter, acid, Return liver, the spleen channel.Tool smooth liver and relieve pain,
The effect of nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, blood deficiency chlorosis etc..
Moutan bark be ranunculaceae peony dry root skin, bitter, the cold in nature, thoughts of returning home, liver and kidney channel, have clearing heat and cooling blood,
Effect promoting blood circulation and removing blood stasis is mainly used for febrile virulent maculae, haematemesis, night fever abating at dawn, lossless hectic fever due to yin, dysmenorrhoea Amenorrhea, carbuncle sore tumefacting virus, falls and flutter
Pain of injury etc..It sees earliest《Sheng Nong's herbal classic》" nourishing yin and lessening fire, solution spot poison, throat, diuresis stasis.Descendant is specially with amur cork tree
Mutually fire is controlled, does not know that the work(of the root bark of tree peony more wins.Red colored person's profit, white flower person mend, and people also seldom realizes, and preferably distinguishes it.".
The effect of fructus alpiniae oxyphyllae is the ripening fruits of Zingiber herbaceous plant intelligence development, has and invigorates the kidney and stops nocturnal emission, invigorating brain and relieving mental uneasiness.Modern medicine
Reason is studies have shown that intelligence development has neuroprotection, tranquilizing soporific, improves the obvious biologic activities such as memory function.
Prepared fleece flower root is that the dried root Processing methods of polygonum multiflorum thunb form.Gas is micro-, taste micro-sweet and it is bitter.Return
Liver, the heart, kidney channel.Have effects that filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles.For blood deficiency chlorosis, dizziness and tinnitus, beard and hair is early
In vain, soreness and weakness of waist and knees etc..Modern study finds that prepared fleece flower root has certain curative effect to depression, syndrome of blood deficiency, and can improve dull-witted big
The ability of learning and memory of mouse.
The present invention is based on traditional chinese medicine concepts, and by famous old docter of TCM according to many decades clinical experience, selected medicine-food two-purpose is former
Material compatibility forms.It is verified using modern pharmacology research method repeated screening, it is found that the composition has nourishing liver and kidney, adjusting the moon
Sun, benefiting qi and nourishing blood, harmonizing emotions effect, can improve pressure leads to anxiety-depression, absent minded, listless, dispirited
It is depressed, ability of learning and memory declines etc..There is clear efficacy of the present invention specific aim, significant effect, effect to be better than each single dose, have
Synergistic function, and using pure natural medical and edible dual purpose plant as raw material, combination is simple, safety and stability, is suitble to take for a long time.
Preferably, in parts by weight, which is made of the following raw material：
20~80 parts of ginseng, 20~80 parts of Radix Paeoniae Alba, 20~80 parts of moutan bark, 20~80 parts of fructus alpiniae oxyphyllae, prepared fleece flower root 20~
80 parts.
Preferably, in parts by weight, which is made of the following raw material：
30~70 parts of ginseng, 30~70 parts of Radix Paeoniae Alba, 30~70 parts of moutan bark, 30~70 parts of fructus alpiniae oxyphyllae, prepared fleece flower root 30~
70 parts.
Preferably, in parts by weight, which is made of the following raw material：
40~60 parts of ginseng, 40~60 parts of Radix Paeoniae Alba, 40~60 parts of moutan bark, 40~60 parts of fructus alpiniae oxyphyllae, prepared fleece flower root 40~
60 parts.
In a specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：People
60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 45 parts of fructus alpiniae oxyphyllae, 45 parts of prepared fleece flower root.
In another specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：
80 parts of ginseng, 80 parts of Radix Paeoniae Alba, 80 parts of moutan bark, 20 parts of fructus alpiniae oxyphyllae, 20 parts of prepared fleece flower root.
In another specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：
50 parts of ginseng, 50 parts of Radix Paeoniae Alba, 50 parts of moutan bark, 50 parts of fructus alpiniae oxyphyllae, 50 parts of prepared fleece flower root.
In another specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：
40 parts of ginseng, 40 parts of Radix Paeoniae Alba, 40 parts of moutan bark, 60 parts of fructus alpiniae oxyphyllae, 60 parts of prepared fleece flower root.
In another specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：
60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 40 parts of fructus alpiniae oxyphyllae, 60 parts of prepared fleece flower root.
In another specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：
20 parts of ginseng, 80 parts of Radix Paeoniae Alba, 20 parts of moutan bark, 80 parts of fructus alpiniae oxyphyllae, 30 parts of prepared fleece flower root.
In another specific embodiment provided by the invention, in parts by weight, which is made of the following raw material：
40 parts of ginseng, 60 parts of Radix Paeoniae Alba, 40 parts of moutan bark, 60 parts of fructus alpiniae oxyphyllae, 40 parts of prepared fleece flower root.
The present invention also provides the preparation methods of the Chinese medicine composition, including：By ginseng, Radix Paeoniae Alba, moutan bark, fructus alpiniae oxyphyllae and
Prepared fleece flower root mixes, and water carries, and obtains Chinese medicine composition.
Preferably, water carry for：The water for being equivalent to 10~20 times of raw material weight is added, 2~3h is kept after boiling, what water carried
Number is 2~3 times.
In a specific embodiment provided by the invention, water carry for：The water for being equivalent to 10 times of raw material weight is added, after boiling
It is 2 times to keep 2h, the number that water carries.
Preferably, water carries and obtains to further include the steps that concentration between Chinese medicine composition.
The present invention also provides a kind of health foods, including Chinese medicine composition provided by the invention.
In the present invention, by Chinese medicine composition of the present invention, routinely technique and auxiliary material are prepared into a variety of doses to the health food
Type, such as tablet, capsule (soft capsule and hard capsule), granule, tablet, pulvis, oral solution, medicinal tea.
The present invention also provides a kind of drugs, including Chinese medicine composition provided by the invention.
In the present invention, by Chinese medicine composition of the present invention, routinely technique and auxiliary material are prepared into a variety of dosage forms to the drug, such as
Tablet, capsule (soft capsule and hard capsule), granule, tablet, pulvis, oral solution, medicinal tea etc..
The present invention also provides Chinese medicine compositions as described above to prepare the use in having effects that the drug of harmonizing emotions
On the way.
The present invention provides a kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and products.With weight
Part meter, the Chinese medicine composition are made of the following raw material：10~100 parts of ginseng, 10~100 parts of Radix Paeoniae Alba, 10~100 parts of moutan bark,
10~100 parts of fructus alpiniae oxyphyllae, 10~100 parts of prepared fleece flower root.The device have the advantages that being：
The present invention is based on traditional chinese medicine concepts, and by famous old docter of TCM according to many decades clinical experience, selected medicine-food two-purpose is former
Material compatibility forms.It is verified using modern pharmacology research method repeated screening, it is found that the composition has nourishing liver and kidney, adjusting the moon
Sun, benefiting qi and nourishing blood, harmonizing emotions effect have the function of adjusting neurotransmitter regulator, protection autonomic nervous function, can improve
Pressure leads to anxiety-depression, absent minded, listless, dispirited, ability of learning and memory decline etc..Effect of the present invention
Clearly there is specific aim, significant effect, significant effect to be better than each single dose, there is synergistic function；
Chinese medicine composition of the present invention is using pure natural medical and edible dual purpose plant as raw material, and combination is simple, safety and stability, is suitble to long-term
It takes.
Specific implementation mode
The invention discloses a kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and product, this fields
Technical staff can use for reference present disclosure, be suitably modified technological parameter realization.In particular, it should be pointed out that all similar replacements
Apparent to those skilled in the art with changing, they are considered as being included in the present invention.The method of the present invention
And application is described by preferred embodiment, related personnel can obviously not depart from the content of present invention, spirit and model
Enclose it is interior to method described herein and application be modified or suitably change and combine, to realize and apply the technology of the present invention.
It is raw materials used in Chinese medicine composition with harmonizing emotions provided by the invention and preparation method thereof and product
Or auxiliary material is available on the market.
Bulk pharmaceutical chemicals ginseng, Radix Paeoniae Alba, moutan bark, fructus alpiniae oxyphyllae, the prepared fleece flower root used in above example meets《The Chinese people
Republic's pharmacopeia》(version in 2015) quality standard.
With reference to embodiment, the present invention is further explained：
Embodiment 1
Herbal composite provided in this embodiment for harmonizing emotions is main former by the medicinal material of following weight proportion
Material is prepared：60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 45 parts of fructus alpiniae oxyphyllae, 45 parts of prepared fleece flower root.
Preparation method is：Ginseng 60g, Radix Paeoniae Alba 60g, moutan bark 60g, fructus alpiniae oxyphyllae 45g, prepared fleece flower root 45g are taken, is added 10 times
The water of amount, protects boiling 2h after boiling, extraction twice, merges filtrate twice, is concentrated into 300mL.
1 pharmacodynamic study evidence of test example
In order to verify the embodiment of the present invention 1 proposition herbal composite the effect of, applicant use press above-described embodiment 1
The raw material proportioning provided prepares water extract by common process, has carried out efficacy validation experiment, as a result as follows：
1. test objective
Study the effect of Chinese herbal medicine extract is to alleviating Anxiety And Depression Symptoms, protection autonomic nervous function.
2. test material
2.1 test specimen
According to above-described embodiment 1 provide raw material proportioning, take ginseng 60g, Radix Paeoniae Alba 60g, moutan bark 60g, fructus alpiniae oxyphyllae 45g,
The water of 10 times of amounts is added in prepared fleece flower root 45g, and boiling 2h is protected after boiling, and extraction twice, merges filtrate twice, is concentrated into 300mL.
The extract of each raw material of ginseng, Radix Paeoniae Alba, moutan bark, fructus alpiniae oxyphyllae, prepared fleece flower root, combination that the preparation method is the same as that of Example 1
The preparation method of object.
2.2 modelings and administration
Rat single cage is raised, and free diet drinking-water, raising is controlled in light and temperature in room, 21 ± 2 DEG C of temperature, illumination
From 8:00 to 20:00, all zoopery operations promulgate that Laboratory Animal Welfare and guideline on probation carry out according to NIH.Rat
It adapts to enter an experiment in after transporting to, adapts to the 1h of drinking-water containing sugar, carry out syrup preference experiment, according to syrup preference base-line data point
Be 9 groups, every group 10~12, i.e., control group, stress group, stress+Prozac group, stress+1 group of embodiment, stress+ginseng extraction
Object, stress+radix paeoniae alba extraction, stress+Cortex Moutan extract, stress+Fructus Alpinae Oxyphyllae extract, stress+Radix Polygoni Multiflori Preparata extract.It answers
Swash and continues 5 weeks, it is daily to be stimulated comprising two to five kinds of different stressors.Stressor include deprive diet drinking-water, tilt mouse cage,
Continuous light, make dirty mouse cage, stroboscopic light stimulation, limitation feed stimulation, folder anal spine swash.Control group does not give any stimulation；It answers
Giving for sharp group stress supply and control group same dose ordinary water simultaneously；Stress+Prozac group give stress and Fluoxetine capsule；It answers
Swash+1 group of embodiment give stress and embodiment 1；Stress+mono- medicament extract give stress and single medicament extract.
2.3 syrup preferences are tested
Unrestricted choice between two bottles of water in offer rat 1 hour, one bottle contains 0.8% aqueous sucrose solution, and one bottle is then pure
Water.To avoid rat hobby drink side water, two vial position half an hour from switching once.Rat Fast prohibits water 23h before experiment, from
Water and syrup consumption are measured by measuring bottle quality, and the calculation basis consumption syrup of syrup preference coefficient accounts for entire liquid and disappears
It consumes percentage to indicate, formula is as follows：
2.4 neurotransmitters detect
Put to death rat broken end, trunk blood is collected into the collecting pipe of standard heparin coating, be put into 4 DEG C of centrifuges with
3000rpm centrifuges 15min, and -20 DEG C of refrigerations of supernatant, ELISA method detection corticoliberim (CRH) is taken to promote
Cortex hormone of aadrenaline (ACTH) and cortisol (CORT) content.
3. test result
3.1 syrup preference experimental results
Syrup preference coefficient (being shown in Table 1) is found after comparing each group Animal stress, compared with stress group, Prozac and reality
Syrup preference coefficient can significantly be increased by applying example 1, illustrate that embodiment 1 has the work for the anhedonia symptom for improving chronic stress rat
With, and effect is better than the effect of each single medicinal material extract.
Influence of 1 embodiment 1 of table to chronic stress rat syrup preference coefficient
| Group | Number of animals (only) | Syrup preference coefficient |
| Control group | 11 | 0.7694±0.0295 |
| Stress group | 10 | 0.6054±0.0633* |
| Stress+Prozac group | 12 | 0.7431±0.0565# |
| Stress+1 group of embodiment | 12 | 0.7384±0.0702# |
| Stress+ginseng extract | 12 | 0.6534±0.0740# |
| Stress+radix paeoniae alba extraction | 12 | 0.6101±0.0423 |
| Stress+Cortex Moutan extract | 12 | 0.6043±0.0735 |
| Stress+Fructus Alpinae Oxyphyllae extract | 12 | 0.6632±0.0242# |
| Stress+Radix Polygoni Multiflori Preparata extract | 12 | 0.6078±0.0345 |
3.2 neurotransmitter testing results
Neurotransmitter testing result (being shown in Table 2) shows that chronic stress can make CRH horizontal significantly raising, ACTH in rat body
It is significantly reduced with CORT levels, CRH, ACTH and CORT level caused by Prozac and embodiment 1 can improve chronic stress are different
Often, illustrate that embodiment 1 has certain neuroprotection, and effect is better than the effect of each single medicinal material extract.
Influence of 2 embodiment 1 of table to chronic stress rat nerve mediator
| Group | Number of animals/only | CRH(ng/ml) | ACTH(pg/ml) | CORT(ng/ml) |
| Control group | 10 | 5.01±0.38 | 34.15±4.27 | 53.73±5.54 |
| Stress group | 10 | 5.97±0.36* | 25.45±2.68* | 42.34±4.94* |
| Stress+Prozac group | 10 | 5.13±0.25# | 33.83±2.26# | 52.09±5.95# |
| Stress+1 group of embodiment | 10 | 5.16±0.29# | 33.28±3.75# | 54.08±1.84# |
| Stress+ginseng extract | 12 | 5.82±0.33 | 26.34±3.45 | 50.01±3.34# |
| Stress+radix paeoniae alba extraction | 12 | 5.69±0.58 | 28.23±1.89 | 43.22±5.34 |
| Stress+Cortex Moutan extract | 12 | 5.76±0.66 | 27.67±2.31 | 45.15±5.01 |
| Stress+Fructus Alpinae Oxyphyllae extract | 12 | 5.61±0.40 | 30.03±2.53# | 51.23±3.32# |
| Stress+Radix Polygoni Multiflori Preparata extract | 12 | 5.65±0.31 | 29.34±5.43# | 46.04±2.35 |
Note：* it indicates compared with the control group, p < 0.05；# expressions are compared with model group, p < 0.05.
4. drug effect is summarized
The above experiment shows that embodiment 1 can improve the anhedonia and nerve mediator water of chronic stress rat model
It is flat abnormal, the effect of having and significantly adjust mood, protect nervous function.Meanwhile test result shows ginseng, Radix Paeoniae Alba, male
This traditional Chinese medicine of the five flavours of the root bark of tree peony, fructus alpiniae oxyphyllae, prepared fleece flower root, which is used cooperatively, has certain synergistic function.
Embodiment 2
Provided by the present invention for harmonizing emotions herbal composite by following weight proportion medicinal material be primary raw material
It is prepared：80 parts of ginseng, 80 parts of Radix Paeoniae Alba, 80 parts of moutan bark, 20 parts of fructus alpiniae oxyphyllae, 20 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Embodiment 3
Provided by the present invention for harmonizing emotions herbal composite by following weight proportion medicinal material be primary raw material
It is prepared：50 parts of ginseng, 50 parts of Radix Paeoniae Alba, 50 parts of moutan bark, 50 parts of fructus alpiniae oxyphyllae, 50 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Embodiment 4
Provided by the present invention for harmonizing emotions herbal composite by following weight proportion medicinal material be primary raw material
It is prepared：40 parts of ginseng, 40 parts of Radix Paeoniae Alba, 40 parts of moutan bark, 60 parts of fructus alpiniae oxyphyllae, 60 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Embodiment 5
Provided by the present invention for harmonizing emotions herbal composite by following weight proportion medicinal material be primary raw material
It is prepared：60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 40 parts of fructus alpiniae oxyphyllae, 60 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Embodiment 6
Provided by the present invention for harmonizing emotions herbal composite by following weight proportion medicinal material be primary raw material
It is prepared：20 parts of ginseng, 80 parts of Radix Paeoniae Alba, 20 parts of moutan bark, 80 parts of fructus alpiniae oxyphyllae, 20 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Embodiment 7
Provided by the present invention for harmonizing emotions herbal composite by following weight proportion medicinal material be primary raw material
It is prepared：40 parts of ginseng, 60 parts of Radix Paeoniae Alba, 40 parts of moutan bark, 60 parts of fructus alpiniae oxyphyllae, 40 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
2 pharmacodynamic study evidence of test example
The effect of in order to verify herbal composite that 2-7 of the embodiment of the present invention is proposed, applicant, which uses, presses above-mentioned implementation
The raw material proportioning that example 2-7 is provided, prepares water extract by common process, has carried out efficacy validation experiment, as a result as follows：
1. test objective
Study the effect of Chinese herbal medicine extract is to alleviating Anxiety And Depression Symptoms, protection autonomic nervous function.
2. test material
2.1 test specimen
Embodiment 2-7 extracts.
2.2 modelings and administration
Rat single cage is raised, and free diet drinking-water, raising is controlled in light and temperature in room, 21 ± 2 DEG C of temperature, illumination
From 8:00 to 20:00, all zoopery operations promulgate that Laboratory Animal Welfare and guideline on probation carry out according to NIH.Rat
It adapts to enter an experiment in after transporting to, adapts to the 1h of drinking-water containing sugar, carry out syrup preference experiment, be divided into 9 according to syrup preference data
Group, every group 10~12, i.e., control group, stress group, stress+Prozac group, stress+2 groups of embodiment, stress+3 groups of embodiment,
Stress+4 groups of embodiment, stress+5 groups of embodiment, stress+6 groups of embodiment, stress+7 groups of embodiment.It stress continue 5 weeks, daily
Including two to five kinds of different stressors are stimulated.Stressor includes depriving diet drinking-water, tilting mouse cage, continuous light, make dirty
Mouse cage, stroboscopic light stimulation, limitation feed stimulation, folder anal spine swash.Control group does not give any stimulation；Stress group is given stress be same
When supply and control group same dose ordinary water；Stress+Prozac group give stress and Fluoxetine capsule；Stress+embodiment 2-7 groups
Give stress and corresponding embodiment 2-7.
2.3 syrup preferences are tested
Unrestricted choice between two bottles of water in offer rat 1 hour, one bottle contains 0.8% aqueous sucrose solution, and one bottle is then pure
Water.To avoid rat hobby drink side water, two vial position half an hour from switching once.Rat Fast prohibits water 23h before experiment, from
Water and syrup consumption are measured by measuring bottle quality, and the calculation basis consumption syrup of syrup preference coefficient accounts for entire liquid and disappears
It consumes percentage to indicate, formula is as follows：
2.4 neurotransmitters detect
Put to death rat broken end, trunk blood is collected into the collecting pipe of standard heparin coating, be put into 4 DEG C of centrifuges with
3000rpm centrifuges 15min, and -20 DEG C of refrigerations of supernatant, ELISA method detection corticoliberim (CRH) is taken to promote
Cortex hormone of aadrenaline (ACTH) and cortisol (CORT) content.
3. test result
3.1 syrup preference experimental results
Syrup preference coefficient (being shown in Table 3) is found after comparing each group Animal stress, compared with stress group, Prozac and reality
Syrup preference coefficient can be increased in various degree by applying a 2-7, illustrate that embodiment 2-7 has the anhedonia for improving chronic stress rat
The effect of symptom.
Influences of the 3 embodiment 2-7 of table to chronic stress rat syrup preference coefficient
| Group | Number of animals (only) | Syrup preference coefficient |
| Control group | 11 | 0.7694±0.0295 |
| Stress group | 10 | 0.6054±0.0633* |
| Stress+Prozac group | 12 | 0.7431±0.0565# |
| Stress+2 groups of embodiment | 12 | 0.6462±0.0624 |
| Stress+3 groups of embodiment | 12 | 0.6962±0.0534# |
| Stress+4 groups of embodiment | 12 | 0.6845±0.0712# |
| Stress+5 groups of embodiment | 12 | 0.7001±0.0213# |
| Stress+6 groups of embodiment | 12 | 0.6221±0.0431 |
| Stress+7 groups of embodiment | 12 | 0.7003±0.0421# |
3.2 neurotransmitter testing results
Neurotransmitter testing result (being shown in Table 4) shows that chronic stress can make CRH horizontal significantly raising, ACTH in rat body
It is significantly reduced with CORT levels, CRH, ACTH and CORT are horizontal caused by Prozac and embodiment 2-7 can improve chronic stress
It is abnormal, illustrate that embodiment 2-7 has certain neuroprotection.
Influences of the 4 embodiment 2-7 of table to chronic stress rat nerve mediator
Note：* it indicates compared with the control group, p < 0.05；# expressions are compared with model group, p < 0.05.
4. drug effect is summarized
The above experiment shows that embodiment 2-7 can improve the anhedonia and neurotransmitter water of chronic stress rat model
It is flat abnormal, the effect of having and adjust mood, protect nervous function.Meanwhile test result show ginseng, Radix Paeoniae Alba, moutan bark,
This traditional Chinese medicine of the five flavours of fructus alpiniae oxyphyllae, prepared fleece flower root, which is used cooperatively, has certain synergistic function.
Comparative example 1
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：10 parts of ginseng, 120 parts of Radix Paeoniae Alba, 10 parts of moutan bark, 120 parts of fructus alpiniae oxyphyllae, 10 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Comparative example 2
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：120 parts of ginseng, 10 parts of Radix Paeoniae Alba, 120 parts of moutan bark, 10 parts of fructus alpiniae oxyphyllae, 120 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Comparative example 3
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 45 parts of fructus alpiniae oxyphyllae, 45 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Comparative example 4
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：60 parts of ginseng, 60 parts of moutan bark, 45 parts of fructus alpiniae oxyphyllae, 45 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Comparative example 5
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 45 parts of fructus alpiniae oxyphyllae, 45 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Comparative example 6
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 45 parts of prepared fleece flower root.
The preparation method is the same as that of Example 1.
Comparative example 7
The herbal composite for harmonizing emotions that this comparative example provides is main former by the medicinal material of following weight proportion
Material is prepared：60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 45 parts of fructus alpiniae oxyphyllae.
The preparation method is the same as that of Example 1.
1 pharmacodynamic study evidence of comparative experimental example
The effect of in order to verify herbal composite that comparative example 1-7 of the present invention is proposed, applicant, which uses, presses above-mentioned comparison
The raw material proportioning that example 1-7 is provided, prepares water extract by common process, has carried out efficacy validation experiment, as a result as follows：
1. test objective
Study the effect of Chinese herbal medicine extract is to alleviating Anxiety And Depression Symptoms, protection autonomic nervous function.
2. test material
2.1 test specimen
Comparative example 1-7 extracts.
2.2 modelings and administration
Rat single cage is raised, and free diet drinking-water, raising is controlled in light and temperature in room, 21 ± 2 DEG C of temperature, illumination
From 8:00 to 20:00, all zoopery operations promulgate that Laboratory Animal Welfare and guideline on probation carry out according to NIH.Rat
It adapts to enter an experiment in after transporting to, adapts to the 1h of drinking-water containing sugar, carry out syrup preference experiment, according to syrup preference base-line data point
Be 10 groups, every group 10~12, i.e., control group, stress group, stress+Prozac group, stress+1 group of comparative example, stress+comparative example 2
Group, stress+3 groups of comparative example, stress+4 groups of comparative example, stress+5 groups of comparative example, stress+6 groups of comparative example, stress+comparative example 7
Group.It stress continue 5 weeks, it is daily to be stimulated comprising two to five kinds of different stressors.Stressor includes depriving diet drinking-water, tilting
Mouse cage, continuous light, make dirty mouse cage, stroboscopic light stimulation, limitation feed stimulation, folder anal spine swash.Control group does not give any thorn
Swash；Stress group is given stress supply and control group same dose ordinary water simultaneously；Stress+Prozac group give stress and Prozac glue
Capsule；Stress+comparative example 1-7 groups give stress and corresponding comparative example 1-7.
2.3 syrup preferences are tested
Unrestricted choice between two bottles of water in offer rat 1 hour, one bottle contains 0.8% aqueous sucrose solution, and one bottle is then pure
Water.To avoid rat hobby drink side water, two vial position half an hour from switching once.Rat Fast prohibits water 23h before experiment, from
Water and syrup consumption are measured by measuring bottle quality, and the calculation basis consumption syrup of syrup preference coefficient accounts for entire liquid and disappears
It consumes percentage to indicate, formula is as follows：
2.4 neurotransmitters detect
Put to death rat broken end, trunk blood is collected into the collecting pipe of standard heparin coating, be put into 4 DEG C of centrifuges with
3000rpm centrifuges 15min, and -20 DEG C of refrigerations of supernatant, ELISA method detection corticoliberim (CRH) is taken to promote
Cortex hormone of aadrenaline (ACTH) and cortisol (CORT) content.
3. test result
3.1 syrup preference experimental results
Syrup preference coefficient (being shown in Table 5) finds that it is inclined that Prozac can significantly increase syrup after comparing each group Animal stress
Good coefficient improves anhedonia symptom, but compared with stress group, comparative example 1-7 syrup preference coefficients do not have significant changes.
Influences of the 5 comparative example 1-7 of table to chronic stress rat syrup preference coefficient
| Group | Number of animals (only) | Syrup preference coefficient |
| Control group | 11 | 0.8204±0.0195 |
| Stress group | 10 | 0.5901±0.0433* |
| Stress+Prozac group | 12 | 0.7502±0.0471# |
| Stress+1 group of comparative example | 12 | 0.6134±0.0453 |
| Stress+2 groups of comparative example | 12 | 0.6212±0.0212 |
| Stress+3 groups of comparative example | 12 | 0.5801±0.0534 |
| Stress+4 groups of comparative example | 12 | 0.6121±0.0321 |
| Stress+5 groups of comparative example | 12 | 0.6019±0.0521 |
| Stress+6 groups of comparative example | 12 | 0.6047±0.0529 |
| Stress+7 groups of comparative example | 12 | 0.6081±0.0487 |
3.2 neurotransmitter testing results
Neurotransmitter testing result (being shown in Table 6) shows that chronic stress can make CRH horizontal significantly raising, ACTH in rat body
It significantly reduces, CRH, ACTH and CORT horizontal abnormality caused by Prozac can improve chronic stress, but compares with CORT levels
Example 1-7 cannot improve neurotransmitter levels abnormality.
Influences of the 6 comparative example 1-7 of table to chronic stress rat nerve mediator
Note：* it indicates compared with the control group, p < 0.05；# expressions are compared with model group, p < 0.05.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (11)
1. a kind of having effects that the Chinese medicine composition of harmonizing emotions, which is characterized in that in parts by weight, be made of the following raw material：
10~100 parts of ginseng, 10~100 parts of Radix Paeoniae Alba, 10~100 parts of moutan bark, 10~100 parts of fructus alpiniae oxyphyllae, prepared fleece flower root 10~
100 parts.
2. Chinese medicine composition according to claim 1, which is characterized in that in parts by weight, be made of the following raw material：
20~80 parts of ginseng, 20~80 parts of Radix Paeoniae Alba, 20~80 parts of moutan bark, 20~80 parts of fructus alpiniae oxyphyllae, 20~80 parts of prepared fleece flower root.
3. Chinese medicine composition according to claim 1 or 2, which is characterized in that in parts by weight, be made of the following raw material：
40-60 parts of ginseng, 40-60 parts of Radix Paeoniae Alba, 40-60 parts of moutan bark, 40-60 parts of fructus alpiniae oxyphyllae, 40-60 parts of prepared fleece flower root.
4. Chinese medicine composition according to claim 3, which is characterized in that in parts by weight, be made of the following raw material：
60 parts of ginseng, 60 parts of Radix Paeoniae Alba, 60 parts of moutan bark, 45 parts of fructus alpiniae oxyphyllae, 45 parts of prepared fleece flower root.
5. the preparation method of Chinese medicine composition as described in any one of claims 1 to 4, which is characterized in that including：By ginseng,
Radix Paeoniae Alba, moutan bark, fructus alpiniae oxyphyllae and prepared fleece flower root mixing, water carry, and obtain the Chinese medicine composition.
6. preparation method according to claim 5, which is characterized in that the water carry for：Addition is equivalent to raw material weight 10
~20 times of water, it is 2~3 times that 2~3h, the number that water carries are kept after boiling.
7. preparation method according to claim 5 or 6, which is characterized in that the water carry for：Addition is equivalent to raw material weight
10 times of water, it is 2 times that 2h, the number that water carries are kept after boiling.
8. preparation method according to claim 5 or 6, which is characterized in that the water is carried obtains Chinese medicine composition with described
Between further include the steps that concentration.
9. a kind of health food, which is characterized in that including the Chinese medicine composition as described in any one of claims 1 to 4.
10. a kind of drug, which is characterized in that including the Chinese medicine composition as described in any one of claims 1 to 4.
11. the Chinese medicine composition described in any one of claim 1-4 is preparing the use in having effects that the drug of harmonizing emotions
On the way.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110448630A (en) * | 2018-05-08 | 2019-11-15 | 无限极（中国）有限公司 | Chinese medicine composition that a kind of alleviation stress, adjust mood and preparation method thereof and purposes |
| CN115957284A (en) * | 2021-10-11 | 2023-04-14 | 苏中药业集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of depression or anxiety drug |
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| CN103861005A (en) * | 2014-03-26 | 2014-06-18 | 胡向仟 | Traditional Chinese medicine composition with anti-anxiety effect |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110448630A (en) * | 2018-05-08 | 2019-11-15 | 无限极（中国）有限公司 | Chinese medicine composition that a kind of alleviation stress, adjust mood and preparation method thereof and purposes |
| CN115957284A (en) * | 2021-10-11 | 2023-04-14 | 苏中药业集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of depression or anxiety drug |
| CN115957284B (en) * | 2021-10-11 | 2024-02-23 | 苏中药业集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for treating or preventing anxiety and/or depression |
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