CN103861005A - Traditional Chinese medicine composition with anti-anxiety effect - Google Patents
Traditional Chinese medicine composition with anti-anxiety effect Download PDFInfo
- Publication number
- CN103861005A CN103861005A CN201410116083.0A CN201410116083A CN103861005A CN 103861005 A CN103861005 A CN 103861005A CN 201410116083 A CN201410116083 A CN 201410116083A CN 103861005 A CN103861005 A CN 103861005A
- Authority
- CN
- China
- Prior art keywords
- anxiety
- chinese medicine
- medicine composition
- traditional chinese
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition with an anti-anxiety effect. The traditional Chinese medicine composition is prepared from the following crude medicaments in parts by weight: 10-18 parts of moutan bark, 10-18 parts of radix paeoniae alba, 6-12 parts of frankincense, 7-10 parts of fructus alpiniae oxyphyllae and 7-10 parts of inula flowers. The traditional Chinese medicine composition is mainly used for treating gas and phlegm obstruction and illness at ease of a sufferer with an anxiety disorder, can be used as an anti-anxiety medicament combination, also can be applied to a maintenance period or prevention of recurrence, and is applied to anxious emotion of a secondary body disease. The traditional Chinese medicine composition is applicable to medicament combination for the sufferer with various anxiety disorders of changeful symptoms and illness procrastination, or a medicament for the maintenance period, or a medicament for prevention of recurrence, is especially applicable to emotion regulation of body disease comorbidities such as anxiety, tumors, strokes, coronary heart diseases and the like. Therefore, the traditional Chinese medicine composition is broad in clinical medication prospect.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition with angst resistance effect.
Background technology
Anxiety is a kind of common emotion, and when its order of severity and objective fact are not inconsistent, or the persistent period is excessively of a specified duration, becomes anxiety disorder (anxiety disororder) to claim again anxiety neurosis.Comprise extensive anxiety, panic attack, Social Anxiety and stress disorders etc.Of common occurrence in daily life, these patient's excessive vigilances, nervous, timidity is feared, sensitivity, or sensation of asphyxia, sense is squeezed in chest contracting, myalgia, insomnia, frequent micturition etc.Entertain imaginary or groundless fears all day, likely all live unhappyly a lifetime.
Chinese scholars report: WHO has carried out the world mental health investigation (WMHS) and cross-culture study to 28 countries including China, from complete 14 epidemiological studies of western countries such as the U.S., New Zealand, Canada, Norway, Germany, Australia of the research, find, in crowd, the lifelong prevalence of anxiety disorder is 13.6%～18.6%, and a year prevalence is 5.6%～19.3%.In the Beijing-Shanghai sample of WHO/WMHS, Shen fishing Estate, Zhang Mingyuan etc. find that to census of population between 5210 18-70 one full year of life anxiety disorder year prevalence is 2.7%.Early, 80～90% morbidities before 35 years old, 10-25 years old are the onset peak age to anxiety disorder age of onset.Anxiety disorder has the chronic course of disease, and relapse rate is high, and altogether sick rate is high, and social function is the feature such as damaged obviously.(drawing certainly: Wu Wenyuan chief editor: " guideline of prevention and treatment of anxiety disorder ", artificial satellite publishing house, the first edition in 2010).
Anxiety disorder, because having chronic or chronic ictal process, therefore needs full course of disease control, in the different phase of the course of disease, needs different measures.This causes the very big difficulty of clinical treatment.At present, Western medicine antianxiety drugs has following three classes:
1) Benzodiazepines: as alprazolam, diazepam, estazolam, clonazepam, chlordiazepoxide etc.
2) the grand class of atropic piperazine: as buspirone, tandospirone.
3) other antidepressants, psychosis, as paroxetine, fluoxetine, escitalopram, deanxit etc. are also used as anxiety.
Although simple western medicine treatment has rapid-action advantage to some patients were, not lasting.And anxiety patient's maintenance phase is very long medicine time, especially prevention of recurrence often need be taken medicine 1-2 years, even longer.Take so for a long time antianxiety drugs, easily cause drug dependence, patient extremely worries, and even someone looks as " drugs ".This worry increases the weight of anxiety on the contrary, or yields treatment.Difficulty in the withdrawal reaction difficulty that doctor faces especially.Therefore, seeking plant amedica antianxity or Chinese medicine preparation has been Chinese scholars common recognition.At present, domestic treatment by Chinese herbs anxiety disorder is still controlled with clinical syndrome differentiation opinion, and decoct is main.There is dialectical disunity, the situation that medication is numerous and diverse.Commercially available Chinese medicine special preparation is few, and new varieties only have " nine taste relieving palpitation granules " a kind of (its component is: Radix Ginseng, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Poria, Radix Polygalae, Rhizoma Corydalis, Radix Asparagi, Radix Rehmanniae Preparata, Cortex Cinnamomi), and its effect is tranquilizing by nourishing the heart, and sphere of action is limited.The Chinese patent medicine of other dispersing the stagnated live-QI to relieve the stagnation of QI, as ease pill, Chaihushugan Pill, Herba Hyperici Monogyni (panacea writing brush grass), capsule for reliving liver and reliving upset, Radix Morindae Officinalis oligosaccharide capsules etc. are also for anxiety.
Not single because of single fruit based on anxiety disorder, due to also non-certain single specific neurotransmitter levels changes.Therefore, the medicine of any single target, is difficult to bring into play the drug effect that regulates anxiety.
Summary of the invention
The present invention is intended to overcome the deficiencies in the prior art, and a kind of Chinese medicine composition with angst resistance effect is provided.
For achieving the above object, technical scheme provided by the invention is:
The described Chinese medicine composition with angst resistance effect is made up of the crude drug of following weight portion:
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion:
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion:
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion:
The dosage form of Chinese medicine composition of the present invention is Chinese herbs decoction.
Below in conjunction with tcm prescription principle, the invention will be further described:
This compositions principle is explained as follows:
Anxiety disorder patient's clinical manifestation can divide spirituality anxiety (expection property anxiety, emotion uneasiness) and somatic anxiety (motion is uneasy), the former take anxiety, anxiety, worry, fear, in terror, as core, the latter is with sympathetic hyperfunction, be on tenterhooks, sensation of asphyxia, myalgia, the somatizations such as frequent micturition are core.The palpitation with fear of this and the traditional Chinese medical science, alarmed and panicky, be insomnia, the emotional disorder such as Bulbus Lilii syndrome, hysteria, globus hystericus has many similar.As described in ancient books and records " make us fearing so and move and uneasy, looking lost, probably as people will catch ".The relevant etiology and pathogenesis traditional Chinese medical science is discussed very auspicious." Plain Questions lift pain opinion " carries: " think the heart and deposit to some extent, god returns to some extent, and healthy energy is stayed and not all right, therefore depressed." Zhang Jingyue says: " and husband's all diseases being caused by disorder of QI, just take gas as use, penetrate everywhere, one have uncomfortable, not sick without institute, therefore it outer has invading of six gas, have nine gas disorderly interior, and disease is that void is for real, for heat is for cold, very its metamorphosis, cannot be described, want to ask it, a positive gas word is enough to use up it, lid gas has uncomfortable part, and sick this whereabouts also ".The treasured visible, gas is the person, circumfluence the whole body, ordinary person's vital organs of the human body, muscles and bones skin and flesh blood vessels, in a moment continuously.Note in worried things if the mind is stayed, gas also condenses not all right thereupon staying note, and it is exactly depressed that the mechanism of qi that hence one can see that " think of " changes.And seven emotions overaction of the five emotions is the utmost point that gas is crossed, gas is crossed heat-dissipating.Zhu Danxi calls " excessive QI becoming fire ", again " expectorant be thing, fall with gas lift, nowhere less than ".The clear ancestor of Tang says in sea: " expectorant be water also, water gas instituteization also, none disease is not in relation to gas, therefore none disease is not in relation to expectorant ".As can be seen here, seven emotions overaction of the five emotions, internal injury is in melancholy anger, gas superinverse, QI rising in reverse order the six channels is obstructed, fluid transformed into phlegm by fire, cause normal spleen to rise stomach and fall, the easypro lung of liver falls, the mechanism of qi multilateds such as heart kidney traffic, but, the source of gas, send out in kidney, for lung, unite in spleen, row, in inner, protects in table.Mechanism of qi is disorderly is not the unbalance of a dirty internal organs.In conjunction with the clinical findings of anxiety disorder, inventor thinks that pathogenesis relates to gas, blood, expectorant.Key is " gas with too ", disorder of movement of QI, and cause depressed stagnation of phlegm, but not refer to more than gas few, so treatment benefit can not, what rush down is unhelpful.Therefore propose: the Therapeutic Principle of " depressed should leading to, expectorant knot should fall ".
Cortex Moutan in the present invention is as monarch drug, and Cortex Moutan has another name called Radix Ardisiae Crispae, Cortex Moutan, wooden Radix Paeoniae etc.For the root of Paeoniaceae plant Cortex Moutan.Main containing paeonol, paeonoside, peoniflorin etc.The property of medicine is arduous, is slightly cold.Enter liver, the heart, kidney channel.Merit is arrogated to oneself cool the blood dissipate blood stasis, and promoting the circulation of QI stimulates the menstrual flow, removing the relative excess heat, flat fire mutually.The gas in the poly-world of Paeonia suffruticosa, the king who spends for group.Its anger is hidden in root, and on root, raw Seedling, therefore claim male (male, staminiferous plant also), is used as medicine for root bark.Carry " Sheng Nong's herbal classic ": " abnormal smells from the patient is pungent cold nontoxic.Main cold and heat, infantile convulsion pathogen ... settling five organs " etc.Clear Zou Shu meaning: " acrid in the mouth can lead to, and gas is cold can fall, and is to think obstruction-removing prescription.Extremely, extremely here gas must be in the institute of all blood, and blood does not declare gas also to stop up ... blood a surname gas is capable, merit first of this Cortex Moutan." Ni Zhumo says: " system can be controlled it for Cortex Moutan, the disease of all vim and vigour." unit's clean quoth: " training the mind will deficiency ".Clear Chen Xiuyuan is said: " Cortex Moutan gas is cold, reports aqueous vapor and enters kidney, obtain golden taste and enter lung, the lung covering and protecting the other ZANG-organs, lung pacify and the five internal organs all pacify ".Ye Tianshi says: " Cortex Moutan is pungent cold, lung benefiting suppressing the hyperactive liver, and irritability does not rise and lung qi falls, and all diseases are flat." be subject to the inspiration of above-mentioned classics, know from experience in conjunction with clinical application, in we, get Cortex Moutan property and flavor of peppery and cold, a surname's venting QI-blood, the flat fire mutually of holding concurrently, beneficial mind.In order to control the moon fire second of the three ten-day periods of the hot season, heat clearing away and restlessness relieving, removing heat from blood promoting the circulation of QI, can tie with general solution.In side, for anxiety disorder patient seven emotions overaction of the five emotions, " gas with too " and cause depressed basic pathogenesis and establish, makes not heat-transformation of gas, and blood does not hinder gas, and blood a surname gas is capable and bring into play the merit of " obstruction-removing prescription ".Therefore be monarch drug.
Cortex Moutan modern pharmacological research is as follows:
1. Cortex Moutan water decoction has antiinflammatory, antiallergic, blood pressure lowering, the effect resisting myocardial ischemia.
2. Cortex Moutan total glycosides Wheat Protein.
Cortex Moutan phenol have antipyretic, antalgic and sedative, antitumor, study of anti-atherogenic effect.
The application of Cortex Moutan in eight first ancient prescriptions is in table 1
Table 1
Yet there are no the research report of single Cortex Moutan anxiety obstacle.
The Radix Paeoniae Alba in the present invention and Olibanum are ministerial drug.
The Radix Paeoniae Alba has another name called Radix Paeoniae Alba, Radix Paeoniae.
For the root of Paeoniaceae plant peony and Peony.Main containing peoniflorin, oxypaeoniflorin, Radix Paeoniae aglycon ketone, peony lactone etc.The acid of property of medicine bitter in the mouth, is slightly cold.Enter liver, spleen channel.Merit is arrogated to oneself and is nourished blood and battalion, relieving spasm to stop pain, adjusts the gas in blood.Radix Paeoniae germinates October, and bloom March, and broken YIN-cold is coagulated freeze and gone out, and takes advantage of yang-energy flourishing and flourish, is the phase in spending.The color that Radix Paeoniae is bright, the gas of strong fragrance, suitable with the gas phase in blood.Can be broken cloudy solidifying, Bu Yang and, can complementary energy rush down, specially promoting the circulation of blood sea, woman's regulating menstruation is multiplex.Clear yellow palace is embroidered and is said: " enter Liver Channel blood system astringing QI.Edge QI belonging to YANG, blood pertaining to YIN, blood is contained in gas, and blood clotting is not all right, it is arrogant that in blood, blood is dry and beneficial withered, the Sheng person of the blood, Bi Laixin is loose for it, the Sheng person of the gas, must rely acid to receive for it, thus the Radix Paeoniae Alba number for holding back the liquid of liver, the gas of receipts liver, and make the not absurd row of gas also." in side, Radix Paeoniae Alba enters blood astringing QI, principal drug assistance Cortex Moutan a surname venting QI-blood, analgesia, therefore be ministerial drug.
Olibanum has another name called nipple perfume (or spice), the perfume (or spice) that collapses, and it pool is fragrant etc.
The resin oozing out for the skin zone of olive subject plant Boswellia carterii.Main resinous, gummy, volatile oil, composition has free α, β-boswellic acid, olibanoresene, and piperitone, pinocamphone etc.The property of medicine tepor of working hard, enters the heart, liver, spleen channel.Merit is arrogated to oneself blood-activating and qi-promoting, inducing menstruation to relieve menalgia, and reinforcing the heart is allayed excitement.The pungent perfume (or spice) of this product, enters heart circulation of qi promoting, can rise and can fall, pain of fixed all warps.Cloud is embroidered in yellow palace: " Olibanum perfume (or spice) is scurried into the heart, can make the logical and muscle of blood a surname from stretching, and reactivation enters kidney temperature compensation, makes gas and blood logical living mutually, does not make blood hinder in order to do gas, and blood is not also hindered by gas, therefore cloud function hemopoietic is studied carefully all product ears of promoting flow of QI and blood." (" book on Chinese herbal medicine is looked for the truth ") Chen Yan of Southern Song Dynasty cloud: " and Olibanum is controlled mental derangement, the sliding nocturnal emission person of essence, and lid is got its soft gluing, and can help his medicine, to restrain mind also." (" Baoqing book on Chinese herbal medicine compromise "), in we, close monarch drug Cortex Moutan and enter blood gas, helps again pain of ministerial drug Radix Paeoniae Alba emergency, favourable mitigation anxiety disorder patient's malaise and all diseases of myalgia, therefore be ministerial drug.
At present commercially available Chinese medicine preparation antianxity has no the Radix Paeoniae Alba, Olibanum and is all the formula of ministerial drug.
Fructus Alpiniae Oxyphyllae in the present invention and Flos Inulae are adjuvant drug.
Fructus Alpiniae Oxyphyllae has another name called the sub-， Zhai of Fructus Alpiniae Oxyphyllae Ding.For the mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.Main containing cyperone, cineole, zingiberene, zingiberol, aminoacid etc.Medicine property and flavor of peppery and warm, enters spleen, kidney channel.Merit is arrogated to oneself warming spleen and stopping diarrha, holds back spleen kidney qi contrary, improving inspiration by invigorating kidney-QI Gui Yuan.The pungent temperature of this product, the gas of the YIN-cold of faling apart, helps spleen and rises stomach and fall, and makes QI movement being in harmonious way and emesis rushes down, and stomachache disappears.Cloud is embroidered in yellow palace: " Fructus Alpiniae Oxyphyllae, abnormal smells from the patient is hot, the special dry spleen stomach warming of merit, and hold back taste QI rising in reverse order, and Zang Na Gui Yuan, the agent of life is mended in number reinforcing the heart again." " Kaibao Bencao " cloud: " peace three warmers, adjust all gas for benefiting vital QI for tranquillizing, tonifying for the deficiency." Liu Yuansu says: " exploitation pent-up, make gas a surname logical ", in we, receive with this take the photograph, warming the spleen, secret essence, make spleen rise stomach and fall, and improving inspiration by invigorating kidney-QI Gui Yuan, prevent taste impaired, collaborative ministerial drug is nursed one's health all gas.Therefore be adjuvant drug.
Flos Inulae has another name called volt flower, FLOSINULAE.For the head inflorescence of feverfew Flos Inulae.Main containing flavonoid glycoside, inusterol B, C, inulin etc.Property of medicine hardship, pungent, salty, tepor, nontoxic.Enter lung, liver, stomach warp.Merit is arrogated to oneself sending down the abnormal ascending QI expectorant, softening the hard mass diuretic, promoting blood circulation.This product temperature can be passed through, and salty energy softening the hard mass, controls QI rising in reverse order, and palpitation with fear is very tested.Li Shizhen (1518-1593 A.D.) is said: " all diseases of controlling, its merit water of being only expert at, the therapeutic method to keep the adverse QI flowing downwards, promoting blood circulation you." clear Zou Shu " herbal classic the is dredged card " cloud of writing: " and two side of body persons, the road of negative and positive, lifting want pivot, water is not returned soil and is tied stagnant air flue, for shying for throbbing with fear, (Flos Inulae) main stagnation of QI and fullness in the hypochondrium, palpitate with fear, i.e. the therapeutic method to keep the adverse QI flowing downwards, the merit dewatering also." get its specially power of main lower and tonneau in we, the effect of performance lifting hinge, collaborative ministerial drug is adjusted pleasant machine, and favourable diuresis and phlem dispersing, therefore be adjuvant drug.
Inventor is subject to the inspiration of ancient Chinese medicine mechanism of qi theory, in conjunction with more than 40 years clinical practice experiences, thinks that the pathogenesis that anxiety disorder relates to is mainly seven emotions overaction of the five emotions.Key is " gas with too " and causes depressed.Zhu Danxi meaning: " excessive QI becoming fire ", fire can fluid transformed into phlegm by fire, and causes gas, blood, expectorant for suffering from, stagnation of Qi and phelgm, and delay is difficult.The pathological changes of this non-dirty internal organs.The Therapeutic Principle of " depressed should leading to, expectorant knot should fall " therefore, is proposed.Medication must first removing heat from blood a surname be led to, and makes not heat-transformation of gas, and blood does not hinder gas, just can reach the object with general solution knot.Newly cognitive according to above-mentioned pathogenesis, Chinese medicine composition of the present invention selects to have that removing heat from blood a surname is logical, and the Cortex Moutan of ruling vim and vigour is monarch drug, is intended to utilize its acrid in the mouth can lead to, and gas is trembled with fear and can be fallen, and the easypro lung of liver is fallen, and mutually fiery Gui Yuan gives full play to the merit of " obstruction-removing prescription ".Minister is with blood system astringing QI, the Radix Paeoniae Alba of relieving spasm to stop pain; Enter heart circulation of qi promoting, the Olibanum of convergence mind, the monarch and his subjects' three medicines are with entering blood system, from removing heat from blood, nourish blood, circulation of qi promoting, the different angles of invigorating blood circulation, the capable power of synthetic blood a surname's gas, assistant is with the kidney warming improving inspiration by invigorating kidney-QI, the Fructus Alpiniae Oxyphyllae of allaying excitement; Sending down the abnormal ascending QI expectorant, the Flos Inulae of promoting blood circulation, adjusts pleasant machine from falling, receive the auxiliary monarch-minister drug in two aspects, stabilizes " too ", the object of gathering altogether with general solution knot.Present composition flavour of a drug are concise, and medical material used is pharmacopeia and records kind, wide material sources, and not containing toxicity medical material.Every day, crude drug amount was moderate, was applicable to making tablet or capsule, favourable exploitation and large-scale production.Be applicable to the each hypotype of anxiety disorder, and the anxiety state of physical disease secondary.Popularizing application prospect is wide.
In short, compared with prior art, beneficial effect of the present invention is:
1, the present invention, according to the new cognition of anxiety disorder pathogenesis, proposes the Therapeutic Principle of " depressed should leading to, expectorant knot should fall ".Give full play to the compound drug effect advantage of the kind regulating QI machine of Chinese medicine.
2, prescription theory is according to abundance, and flavour of a drug are concise, and crude drug source is extensive, and avirulence medical material does not relate to the problem such as environmental protection and animal and plant protection yet.
3, this compositions crude drug every day amount moderate (40～68g), is applicable to making tablet or capsule and large-scale production.Cost is low, is conducive to apply.
4, this compositions is applied widely, both can be used as the drug combination of the each hypotype of anxiety disorder, also can be used for maintenance phase or prevention of recurrence.Or be total to sick treatment for anxiety and physical disease.
In a word, the present invention is from anxiety disorder seven emotions overaction of the five emotions, and the basic pathogenesis of " gas with too " is started with, and with row, hold back, fall, receive and select medicine, all recurrence due to taking drug close, and have removing heat from blood a surname logical, promoting the circulation of QI expectorant, effect of mind tranquilizing.The present invention is on the basis of the relevant Pathogenesis Theory of the cognitive traditional Chinese medical science again, according to the Chinese medicine compound monarch principles of formulating prescriptions, gives full play to the compound drug action of compositions.Existing calmness and the effect of relaxing, non-sleeping peacefully again, more can not cause the dyskinesia.Long-term taking is without addiction, and safety is good.Cure mainly anxiety disorder patient's depressed stagnation of phlegm, malaise.Both can be used as drug combination antianxity, also can be used for maintenance phase, or prevention of recurrence medication.And for being secondary to the anxiety of physical disease.Be applicable to symptom changeable, various types of anxiety disorder patient drug combinations of course of disease delay, or maintenance phase medication, or prevention of recurrence.Be particularly suitable for the physical diseases such as anxiety and tumor, apoplexy, the coronary heart disease use of sick mood regulation altogether.Its clinical application has a extensive future.
The specific embodiment
Embodiment 1(model case one)
Qiu × ×, women, 45 years old, main suit's anxiety and tense, frightened worried, the June such as palpitation and restlessness
Nineteen ninety marries, infertile for many years after marriage, seeks medical advice everywhere.Do diagnosis dilatation and curettage in January, 1997, in art, without significant discomfort, but postoperatively occurs colporrhagia.Patient is more panic, listens colleague to say the possibility of cancer, and more nervous, sense is nervous, tachypnea.After 2 weeks, treated stopped bleeding, but patient still fear suffer from incurable disease, be again afraid of can not fertility meeting be abandoned by husband.Tell insomnia, agitation, but still can adhere to work and manage household affairs.After 3 months, symptom increases the weight of, and there is ictal extreme agitation, feel restless, rapid breathing, uncomfortable in chest, cardiopalmus, perspiration, xerostomia, numbness of hands and feet.Conscious meeting goes mad, become stupid, has dying sense, and each outbreak does not continue half an hour to 1 hour not etc., almost all has outbreak every day.The outbreak intermission still has agitation, worries to send out again, but still can draw oneself up.After 5 months, symptom is more serious, without obvious intermission, all day among greatly alarmed.Be reluctant that mental hospital sees a doctor, lover have to ask doctor to family, and patient catches doctor not put, repeatedly the slight illness of narration oneself.Often look for without reason lover noisy, the discomfort of oneself is attributed to lover and is indifferent to, does not understand.Lie awake all night, also do not allow husband sleep peacefully, very harsh to husband, require him docile, otherwise just make a scene.Fearness listens to the radio, is afraid of to see TV, and frightening bothering, but around nobody feels again very lonely.The women who sees divorce or the death of one's spouse recalls the past memories, and occurs in the heart " a burst of angor ".Pinched look, chatters all day, shout " terribly ".When serious, tear hair, two handss do not stay in abdominal part and rub, and cause epigastrium skin rubefaction, swelling.So far the ability that, has completely lost work and managed household affairs.
Previously body is strong: premorbid personality irritability, irritability, eager to do well in everything stubbornness, attack well, intolerant, suspicious worry too much, do things irresolute.Deny spiritedness illness and hereditary history in family.
Physical examination: no abnormality seen.Thready and stringy pulse, red tongue, yellow fur.
Interview: consciousness is clear, and instrument is whole, contact cooperation, without hallucination vain hope, anxiety, attention cannot be concentrated, and can not keep quite, and action is many, rubs hands and stamps foot, walks up and down.
Lab testing: blood, routine urinalysis, T3T4, hepatic and renal function is all normal; Electrocardioscopy is normal; Rabat is normal;
Psychometry before treatment:
1, the factorial analysis of SCL-90: somatization 2.8, force 1.8, interpersonal sensitivity 2.1, depressed 2.3, and anxiety 4.0 is hostile 2.1, and other are 3.1 years old.Total score: 18.2, suggest severe anxiety.
2, Analysisof Self-rating Anxiety Scale (SAS): standard is divided 75 points, prompting anxiety.
3, Ganzangxiang of TMC emotion rating scale (ERSG): the Liver Channel factor 8.9, anxiety neurosis 18.9, the depressed factor 15.6, prompting has obvious anxiety.
(note: ERSG, by establishments such as Hu Suiyu, Wang Zhe, Cai Taisheng, is shown in Zhang Zuoji chief editor " behavioral medicine scale handbook " Chinese medical electronics audio & video publisher.2005 1 edition 239 pages-243 pages)
Diagnosis: extensively anxiety.Differential diagnosis in tcm: depressed stagnation of phlegm.
Administration: the oral agents of the Chinese medicine composition of angst resistance effect: Cortex Moutan 12g Radix Paeoniae Alba 18g Olibanum 6g Fructus Alpiniae Oxyphyllae 7g Flos Inulae 7g (totally 42 doses of confessions are gone to a doctor for 4 times).
After taking medicine, sleep recovers normal, has and feels nervous though even, easily loosens, and can normally manage household affairs, and gets along as usual with household.
Psychometry: SCL-90 after treatment: somatization 1.2, force 1.1, interpersonal sensitivity 1.0, depressed 1.0, anxiety 1.2 is hostile 0.9, other 1.3, point rate that subtracts is 57.69%.
SAS:36, point rate that subtracts is 52.0%.
ERSG: the Liver Channel factor 4.1, anxiety neurosis 8.7, the depressed factor 8.5, point rate that subtracts is 50.0%.
Observe 42 days clinical effectively.
Embodiment 2(model case two)
Old × ×, male, 32 years old, engineer.Cause without reason anxiety is feared, causes health not good, cannot normally work medical.It is nervous that patient usually feels over the past half year, and gratuitous striking fear into and anxiety are worried.What think at heart is nearly all the thing of worry, as feared, working is late, worries unemployedly, is afraid of to process bad etc. with Peer Relationships.To such an extent as to be difficult to fall asleep, cannot normally work.Feel that own stress is large, colleague has also always said the own anxiety of working too, but oneself does not think that this is problem, and work strain should be energetic performance.Also once attempting listens to the music allows and oneself loosens, and can still cannot focus one's attention on, and is also difficult to eliminate more and more significantly worried.Health is not good, usually feels uncomfortable in chest, and what whole body migration was indefinite aches, and muscular tone is sorely distressed.Go examination in hospital but not find any organic disease.
Previously body is strong: premorbid personality irritability, doing work, it is perfect to require.Deny spiritedness illness and hereditary history in family.
Physical examination: no abnormality seen, stringy pulse, red tongue, yellow fur.
Interview: mental awareness is clear, instrument is rectified, contact cooperation, it is concentrated that attention is owed, and requires urgent.
Lab testing: blood, routine urinalysis, T3T4, hepatic and renal function is all normal; Electrocardioscopy is normal; Rabat is normal.
Psychometry before treatment: 1, SCL-90 test: somatization 1.8, force 1.9, interpersonal sensitivity 2.5, depressed 1.6, anxiety 3.9 is hostile 2.0, other 3.3, total score 17.
2, SAS: standard divides 74, suggest severe anxiety.
3, ERSG: the depressed factor 15.1 of the Liver Channel factor 10.4 anxiety neurosis 16.6 is pointed out obvious anxiety.
Diagnosis: extensively anxiety.Dialectical: depressed stagnation of phlegm.
Administration: the oral agents of the Chinese medicine composition of angst resistance effect: Cortex Moutan 15g Radix Paeoniae Alba 15g Olibanum 12g Fructus Alpiniae Oxyphyllae 9g Flos Inulae 10g (totally 42 doses of confessions are gone to a doctor for 4 times).
Symptom after taking medicine obviously improves, and it is normal that sleep recovers, and systemic pain disappears substantially, has nervously though even, can control, and recovery is normally worked.
Psychometry after treatment: 1, SCL-90 test: somatization 0.7, force 0.9, interpersonal sensitivity 1.5, depressed 1.0, anxiety 1.7 is hostile 1.0, other 1.2, total score 8.0.Subtracting point rate is 52.94%.
2, SAS: standard divides 36, point rate that subtracts is 51.35%.
3, ERSG: the Liver Channel factor 7.0, the depressed factor 6.2 of anxiety neurosis 7.6, point rate that subtracts is 50.6%, observe 42 days clinical effectively.
Embodiment 3(model case three)
Willow × ×, female, 34 years old, accounting.Main suit: psychentonia, sleep poor, inferior belly gas pain, frequent micturition, worries enuresis half a year.Patient is because of first love failure, and psychentonia appears suddenly in normal sense, is afraid of the talk with people, sleeps poor, repeatedly occurs inferior belly gas pain, and frequent micturition is usually worried the wet trousers of urine, and while going out, outstanding sense is worried.But never there is the enuresis.Once medical urinary system training repeatedly, every inspection is all normal, and doctor's advice is loosened, is loosened, oneself also attempt to make great efforts to do, but It dones't help the situation.Have a hunch health worse and worse, and nervous outbreak is frequent.Colleague is also refused to introducing object, thinks and will wait until that the healthy ability of physical recovery is in love.
Previously body is strong, works careful and responsible, and accounting event is familiar with, and Meeting People is always blushed.Disease and hereditary medical history are a cup too low in family.
Physical examination: no abnormality seen, thready pulse, red tongue, yellow fur.
Interview: mental awareness is clear, clothing is neat, the anxiety of answering a question, blushes; Can not loosen, seek medical advice anxious
Lab testing: blood, routine urinalysis, T3T4, hepatic and renal function is all normal; Electrocardioscopy is normal; Rabat is normal, Abdominal B type ultrasonography no abnormality seen.
Psychometry before treatment: 1, SCL-90 Cause of body 1.9, force 1.9, interpersonal sensitivity 2.9, depressed 1.5, anxiety 4.1 is hostile 2.5, other 3.1, total score 17.6, points out obvious anxiety
2, SAS standard is divided: 69
3, the ERSG Liver Channel factor 11.7, the depressed factor 14.1 of anxiety neurosis 17.5
Diagnosis: extensively anxiety.Dialectical: depressed stagnation of phlegm.
Administration: the oral agents of the Chinese medicine composition of angst resistance effect: Cortex Moutan 10g Radix Paeoniae Alba 18g Olibanum 6g Fructus Alpiniae Oxyphyllae 10g Flos Inulae 7g (totally 42 doses of confessions are gone to a doctor for 4 times).
Frequent micturition basic controlling after taking medicine, no longer refuses other people and introduces object.
Psychometry after treatment: 1, SCL-90: Cause of body 1.8, force 1.0, interpersonal sensitivity 1.4, depressed 0.9, anxiety 0.8 is hostile 0.7, other 1.1, total score 17.6, point rate that subtracts is 52.3%.
2, SAS standard is divided: 35, and point rate that subtracts is 49.28%
3, the ERSG Liver Channel factor 6.3, the depressed factor 5.5 of anxiety neurosis 7.6, point rate that subtracts is 55.2%, observe 42 days clinical effectively.
Embodiment 4(zoopery one)
This compositions decoct (sample medicinal liquid) acute toxicity test:
Sample medicinal liquid and dosage: Cortex Moutan 18g Radix Paeoniae Alba 18g Olibanum 12g Fructus Alpiniae Oxyphyllae 10g Flos Inulae 10g
Sample medicinal liquid is given mouse stomach with Cmax (crude drug) 308%, gavage volume is 0.4ml/10g body weight, 1 administration, this is mice dosage 132.2g/kg crude drug, quite 126.9 times of 70kg adult's clinical application amount (68 grams), Continuous Observation 10 days, animal diet followed, activity, hair color feces are all normal, without animal dead.Body weight and the contrast of blank group after experiment, no significant difference (P>0.05).Dissect animal, the internal organs such as perusal mouse core, liver, lung, kidney are showed no extremely, show that sample medicinal liquid maximum tolerated dose is 132.2g/kg crude drug, without acute toxic reaction.
Embodiment 5(zoopery two)
Sample medicinal liquid gavages, the impact on normal spontaneous activity in mice:
Sample medicinal liquid I and dosage: Cortex Moutan 10g Radix Paeoniae Alba 10g Olibanum 6g Fructus Alpiniae Oxyphyllae 7g Flos Inulae 7g
Sample medicinal liquid II and dosage: Cortex Moutan 18g Radix Paeoniae Alba 18g Olibanum 12g Fructus Alpiniae Oxyphyllae 10g Flos Inulae 10g
Select 18-22g Kunming mouse, male and female are regardless of, and are divided at random blank group, gavage normal saline; Buspirone matched group (converting for 30mg/ days by adult); Sample medicinal liquid I group (40g/ days. adult's clinical equivalent amount), sample medicinal liquid II group (68g/ days. adult's clinical equivalent amount), every group 10, after gastric infusion 60 minutes, adopt naked eyes direct observational method, measure mice walk about the time in 2 minutes (S), two forelimbs are upwards praised number of times (observing altogether 3 times), in table 1.Result show sample medicinal liquid and buspirone all have inhibitory action to spontaneous activity in mice, and part is proved this compositions and had the sedation of relaxing.
The impact (n=10, X ± S) of table 1 sample medicinal liquid on each group of spontaneous activity in mice
Δ and blank group compare: before P<0.01* and administration, compare: P<0.01
Embodiment 6(zoopery three)
Anti-stress test: sample medicinal liquid gavages the impact on mice normal pressure resistant anoxia:
Sample medicinal liquid I, II and dosage lead to zoopery two.
Select 18-22g Kunming clock mice, male and female are certificate not, is divided at random blank group, buspirone matched group (converting for 30mg/ days by adult); Sample medicinal liquid I group (40g/ days. adult's clinical equivalent amount), sample medicinal liquid II group (68g/ days. adult's clinical equivalent amount), 8 every group.After gastric infusion 30 minutes, only put into 200ml ground wide mouthed bottle by single mice, cover tightly sealing, timing immediately, take respiratory arrest as index, observes mice because of the dead time (dividing) of anoxia.Result show sample medicinal liquid is compared compared with blank group, buspirone group, is improved the effect of mice normal pressure resistant anoxia, points out this compositions to have certain anti-stress effect.
The impact (divide X ± S) of table 2 sample medicinal liquid on mice normal pressure resistant anoxia
Δ and blank group compare: P<0.01* and buspirone group comparison: P<0.01.
Claims (5)
1. a Chinese medicine composition with angst resistance effect, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
2. Chinese medicine composition as claimed in claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
3. Chinese medicine composition as claimed in claim 2, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
4. Chinese medicine composition as claimed in claim 3, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
5. the Chinese medicine composition as described in claim 1 to 4 any one, is characterized in that, the dosage form of described Chinese medicine composition is Chinese herbs decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410116083.0A CN103861005B (en) | 2014-03-26 | 2014-03-26 | A kind of Chinese medicine composition with angst resistance effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410116083.0A CN103861005B (en) | 2014-03-26 | 2014-03-26 | A kind of Chinese medicine composition with angst resistance effect |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103861005A true CN103861005A (en) | 2014-06-18 |
| CN103861005B CN103861005B (en) | 2016-03-30 |
Family
ID=50900392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410116083.0A Active CN103861005B (en) | 2014-03-26 | 2014-03-26 | A kind of Chinese medicine composition with angst resistance effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103861005B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721551A (en) * | 2017-04-14 | 2018-11-02 | 无限极（中国）有限公司 | A kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and product |
| CN112426454A (en) * | 2020-12-07 | 2021-03-02 | 琛蓝(美国)营养制品股份有限公司 | Traditional Chinese medicine compound composition with anti-anxiety effect and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310740A (en) * | 2007-05-24 | 2008-11-26 | 上海欣生源药业有限公司 | Anti-anxiety compound traditional Chinese medicine and preparation method thereof |
| CN101708281A (en) * | 2009-12-10 | 2010-05-19 | 袁尚礼 | Chinese medicinal preparation for nourishing heart and tranquilizing mind and preparation method thereof |
| CN102949513A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medical health protection product for alleviating anxiety neurosis and preparation method thereof |
| CN103599471A (en) * | 2013-10-21 | 2014-02-26 | 张霞 | Traditional Chinese medicine composition for young female depression |
-
2014
- 2014-03-26 CN CN201410116083.0A patent/CN103861005B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310740A (en) * | 2007-05-24 | 2008-11-26 | 上海欣生源药业有限公司 | Anti-anxiety compound traditional Chinese medicine and preparation method thereof |
| CN101708281A (en) * | 2009-12-10 | 2010-05-19 | 袁尚礼 | Chinese medicinal preparation for nourishing heart and tranquilizing mind and preparation method thereof |
| CN102949513A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medical health protection product for alleviating anxiety neurosis and preparation method thereof |
| CN103599471A (en) * | 2013-10-21 | 2014-02-26 | 张霞 | Traditional Chinese medicine composition for young female depression |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721551A (en) * | 2017-04-14 | 2018-11-02 | 无限极（中国）有限公司 | A kind of Chinese medicine composition with harmonizing emotions and preparation method thereof and product |
| CN112426454A (en) * | 2020-12-07 | 2021-03-02 | 琛蓝(美国)营养制品股份有限公司 | Traditional Chinese medicine compound composition with anti-anxiety effect and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103861005B (en) | 2016-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101856482B (en) | Pure Chinese medicinal preparation for treating mental illness and preparation method thereof | |
| CN102198241A (en) | Medicine for alleviating nervousness and taking care of sub-health | |
| CN103520640B (en) | Traditional Chinese medicine for treating depression | |
| CN103585478B (en) | Chinese medicinal composition for treating hypertension | |
| CN103721075B (en) | A kind of Chinese medicine for post gynecologic operation and preparation method thereof | |
| CN103599474B (en) | A kind of Chinese medicine composition being used for the treatment of poor sleeping quality | |
| CN103861005B (en) | A kind of Chinese medicine composition with angst resistance effect | |
| CN103550549B (en) | A kind of Chinese medicine composition for the treatment of deficiency of heart-yin | |
| CN103223123B (en) | Perimenopausal syndrome treatment drug composition, preparation method and uses thereof | |
| CN105456818A (en) | Traditional Chinese medicine composition containing folium artemisiae argyi and being capable of treating insomnia and preparation method of traditional Chinese medicine composition | |
| CN104888152A (en) | Traditional Chinese medicine preparation for treating postpartum depression and preparation method therefor | |
| CN105796789A (en) | Traditional Chinese medicine preparation for treating coronary heart disease | |
| CN103920058A (en) | Traditional Chinese medicine preparation for treating headache and preparation method thereof | |
| CN105233078A (en) | Traditional Chinese medicine composition for treating viral hepatitis | |
| CN104958677A (en) | Traditional Chinese medicine preparation for treating membranous nephropathy and preparation method of traditional Chinese medicine preparation | |
| CN104873919A (en) | Traditional Chinese medicine composition for treating intestinal tract disease | |
| CN103599279B (en) | Traditional Chinese medicinal preparation for treating diabetes | |
| CN107898990A (en) | A kind of Chinese medicine preparation for treating neurosis and preparation method thereof | |
| CN108295126B (en) | Traditional Chinese medicine composition for treating irritable bowel syndrome and preparation method and application thereof | |
| CN105920409A (en) | Medicinal preparation for treating Alzheimer disease and application of medicinal preparation | |
| CN105831751A (en) | Health-care traditional Chinese medicine composition with effects of tonifying qi and strengthening brain and preparation method and using method thereof | |
| CN105770563A (en) | Traditional Chinese medicine preparation for treating anxiety disorder and preparation method for traditional Chinese medicine preparation | |
| CN105148206A (en) | Traditional Chinese medicine for treating coronary heart disease | |
| CN104352648A (en) | Traditional Chinese medicine preparation for treating headache due to deficiency of blood | |
| CN103638187B (en) | A kind of Chinese medicine and manufacture method for the treatment of LUPUS NEPHRITIS IN CHILDREN |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |