CN101804148A - Medicinal composition with function of improving sleeping and preparation method thereof - Google Patents
Medicinal composition with function of improving sleeping and preparation method thereof Download PDFInfo
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- CN101804148A CN101804148A CN200910078094A CN200910078094A CN101804148A CN 101804148 A CN101804148 A CN 101804148A CN 200910078094 A CN200910078094 A CN 200910078094A CN 200910078094 A CN200910078094 A CN 200910078094A CN 101804148 A CN101804148 A CN 101804148A
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- rhizoma
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- bulbus lilii
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Abstract
The invention discloses a medicinal composition with the function of improving sleeping and a preparation method thereof. The medicinal composition is prepared from valerian, spina date seed, lily and lotus seeds in a certain weight proportion. The medicinal composition has the function of improving sleeping.
Description
Technical field
The present invention relates to a kind of have improve sleep function pharmaceutical composition and preparation method thereof, be the health food of feedstock production specifically with the Chinese herbal medicine.
Background technology
The people has time of 1/3rd to spend in sleep, and sleep is the important step of body recovery, integration and consolidation memory, can make one day brain and health tired to obtain repairing and having a rest, so sleep is very important.Yet, along with the quickening of social life rhythm, the increase of life stress, increasing people joins the main forces of insomnia.There is data to show, the puzzlement person who find to be subjected to difficulty falling asleep in the people investigation surplus several big cities ten thousand such as Shanghai, Beijing, Guangzhou, easily wake up, dreaminess, early awakening, the back of waking up is difficult for insomnia problem such as sleeping is up to 42.5%, and mostly is the white collar personage who is engaged in strong mental work such as IT, management greatly.NIH has been announced a statistical data, and about 7,000 ten thousand Americans are perplexed by sleeping problems.Sleeping pill commonly used clinically at present has Benzodiazepines, barbiturates and other non-barbiturates, the effect of its Cure for insomnia is apparent in view, but it is bigger for liver, kidney influence, the user is easy to generate the dependency to medicine, usually dosage need be continued to increase and effect could be kept, therefore, be not the suitable medicine of taking for a long time.
Summary of the invention
The invention provides a kind of new pharmaceutical composition, said composition has the function of improving sleep.
Another object of the present invention provides the preparation method of aforementioned pharmaceutical compositions.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material: Rhizoma et radix valerianae 3-50 part, Semen Ziziphi Spinosae 1-20 part, Bulbus Lilii 1-20 part, Semen Nelumbinis 1-10 part.
The preferred weight portion proportioning of described pharmaceutical composition is: 15 parts of Rhizoma et radix valerianaes, 10 parts of Semen Ziziphi Spinosaes, 9 parts of Bulbus Liliies, 6 parts in Semen Nelumbinis.
The present invention also provides the preparation method of described Chinese medicine composition, it is characterized in that, adds alcohol reflux in compositions, and extracting solution reclaims ethanol, concentrated, drying under reduced pressure.
The present invention also further provides the purposes of described pharmaceutical composition, and this drug regimen is used for improving sleep.
Preparation of drug combination method of the present invention is as follows:
Get Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Bulbus Lilii, Semen Nelumbinis in proportion, add 6-8 times of 60-75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, reclaim ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract, add appropriate amount of auxiliary materials, be prepared into pharmaceutically acceptable oral formulations, for example capsule, tablet, pill, granule, drop pill etc.Preferred particulates agent, soft capsule dosage form.
The preparation method of the preferred granule of Chinese medicine composition of the present invention is as follows:
Get Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Bulbus Lilii, Semen Nelumbinis in proportion, add 6-8 times of 60-75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract; Extract is ground into fine powder, uses 95% alcohol granulation, be drying to obtain granule.
The preparation method of the preferred soft capsule of Chinese medicine composition of the present invention is as follows:
Get Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Bulbus Lilii, Semen Nelumbinis in proportion, add 6-8 times of 60-75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract, it is standby to cross 100 eye mesh screens; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, after preventing being chilled to room temperature, adding extract powder, appropriate vitamin E grind well with colloid mill, get medicinal liquid; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
In pharmaceutical composition of the present invention, the mechanism of action of each medicine is as follows:
Rhizoma et radix valerianae: be the dry foundation rhizome of Valerianaceae plant Rhizoma et radix valerianae.Tranquilizing mind, wind-damp dispelling, qi and blood circulation promotion, analgesic effect are arranged, and pharmacological research proof Rhizoma et radix valerianae has sedation, can strengthen corticocerebral process of inhibition, lowers reflex excitability, removes smooth muscle spasm.Can and help for sleep as slight tranquilizer.Rhizoma et radix valerianae is the folks of china medical herbs, is widely used in treating neurasthenia, insomnia, hystero epilepsy, lumbago and skelalgia, stomach abdominal distention and pain and traumatic injury, and curative effect is preferably arranged.
Semen Ziziphi Spinosae: be the seed of Rhamnaceae plant Ziziphi Spinosae.Nature and flavor are sweet, flat, go into the heart, spleen, liver, gallbladder meridian.Nourishing heart arranged, calm the nerves, the effect of arresting sweating, be used for neurasthenia, insomnia, dreaminess, night sweat.This product contains volume fatty oil, protein, Jujuboside and vitamin C, and pharmacological testing proof Semen Ziziphi Spinosae has calmness, hypnosis, analgesia, anticonvulsant action.
Bulbus Lilii: be the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Bulbus lilii concoloris Bulbus Lilii.Sweet in the mouth, cold nature, GUIXIN, lung meridian.But nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization is used for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.
Semen Nelumbinis: be the dry mature seed of nymphaeaceae plant lotus.Nature and flavor are sweet, puckery, and are flat.Return spleen, kidney, heart channel.But spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.Be used for insufficiency of the spleen chronic diarrhea, seminal emission leukorrhagia, palpitation and insomnia.
Below, foregoing of the present invention is described in further detail by the specific embodiment:
Concrete embodiment
Embodiment 1:
Get Rhizoma et radix valerianae 1.5kg, Semen Ziziphi Spinosae 1.0kg, Bulbus Lilii 0.9kg, Semen Nelumbinis 0.6kg, add 6 times of amount 75% alcohol reflux 2 times, each 1 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract; Extract is ground into fine powder, uses 95% alcohol granulation, be drying to obtain.
Embodiment 2:
Get Rhizoma et radix valerianae 7.5kg, Semen Ziziphi Spinosae 5kg, Bulbus Lilii 4.5kg, Semen Nelumbinis 3kg, add 6 times of 75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract, it is standby to cross 100 eye mesh screens; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, after preventing being chilled to room temperature, add extract powder, appropriate vitamin E, grind well, get medicinal liquid (Cera Flava: soybean oil: extract: vitamin E=2: 72: 25: 1) with colloid mill; Other get gelatin, glycerol, water, methyl hydroxybenzoate (1: 0.45: 1: 0.001) put in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
Embodiment 3:
Get Rhizoma et radix valerianae 1.2kg, Semen Ziziphi Spinosae 1.0kg, Bulbus Lilii 1.0kg, Semen Nelumbinis 0.9kg, add 6 times of amount 60% alcohol reflux 2 times, each 1 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract; Extract is ground into fine powder, uses 95% alcohol granulation, be drying to obtain.
Embodiment 4:
Get Rhizoma et radix valerianae 6kg, Semen Ziziphi Spinosae 5kg, Bulbus Lilii 5kg, Semen Nelumbinis 4.5kg, add 8 times of 60 alcohol reflux 2 times, each 1 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), extract, it is standby to cross 80 eye mesh screens; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, after preventing being chilled to room temperature, add extract powder, appropriate vitamin E, grind well, get medicinal liquid (Cera Flava: soybean oil: extract: vitamin E=2: 72: 25: 1) with colloid mill; Other get gelatin, glycerol, water, methyl hydroxybenzoate (1: 0.45: 1: 0.001) put in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
Claims (6)
- One kind have improve sleep function pharmaceutical composition and preparation method thereof, it is characterized in that this pharmaceutical composition is to be made by following bulk drugs:Rhizoma et radix valerianae 3-50 part, Semen Ziziphi Spinosae 1-20 part, Bulbus Lilii 1-20 part, Semen Nelumbinis 1-10 part.
- 2. pharmaceutical composition according to claim 1 is characterized in that, the best proportioning of said composition is:15 parts of Rhizoma et radix valerianaes, 10 parts of Semen Ziziphi Spinosaes, 9 parts of Bulbus Liliies, 6 parts in Semen Nelumbinis.
- 3. claim 1 or 2 described preparation of drug combination methods is characterized in that this method is:Get Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Bulbus Lilii, Semen Nelumbinis in proportion, add 6-8 times of 60-75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, reclaim ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract, add appropriate amount of auxiliary materials, be prepared into pharmaceutically acceptable oral formulations, for example capsule, tablet, pill, granule, drop pill etc.Preferred particulates agent, soft capsule dosage form.
- 4. according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:Get Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Bulbus Lilii, Semen Nelumbinis in proportion, add 6-8 times of 60-75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract; Extract is ground into fine powder, uses 95% alcohol granulation, be drying to obtain.
- 5. according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:Get Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Bulbus Lilii, Semen Nelumbinis in proportion, add 6-8 times of 60-75% alcohol reflux 2 times, each 1-1.5 hour, filtrate merged, and reclaimed ethanol, concentrate, drying under reduced pressure (60 ℃ ,-0.08Mpa), get extract, it is standby to cross 100 eye mesh screens; Get an amount of Cera Flava and put in the soybean oil, be heated to fusion, after preventing being chilled to room temperature, add extract powder, appropriate vitamin E, grind well, get medicinal liquid with colloid mill; Other gets gelatin, glycerol, water, antiseptic and puts in right amount and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, rubber solution, 60 ℃ of insulations are standby; Get above-mentioned medicinal liquid and rubber solution, be pressed into ball, be drying to obtain with the soft capsule production equipment.
- 6. claim 1 or 2 described pharmaceutical compositions have the effect that improves sleep.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910078094A CN101804148A (en) | 2009-02-16 | 2009-02-16 | Medicinal composition with function of improving sleeping and preparation method thereof |
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| CN200910078094A CN101804148A (en) | 2009-02-16 | 2009-02-16 | Medicinal composition with function of improving sleeping and preparation method thereof |
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| CN101804148A true CN101804148A (en) | 2010-08-18 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056083A (en) * | 2013-03-22 | 2014-09-24 | 张�诚 | Traditional Chinese medicine composition for relieving stress and promoting sleep |
| CN104664371A (en) * | 2015-01-28 | 2015-06-03 | 刘高胜 | Chewable tablets for improving sleeping quality |
| CN106361964A (en) * | 2016-11-11 | 2017-02-01 | 南方医科大学 | Traditional Chinese medicinal composition for improving sleep quality as well as preparation method and application of traditional Chinese medicinal composition |
| CN108720016A (en) * | 2018-06-07 | 2018-11-02 | 中泰宜佳健康科技（北京）有限责任公司 | A kind of mental composition and its preparation method and application that takes good care of one's sight |
| CN108771238A (en) * | 2018-06-28 | 2018-11-09 | 重庆市中药研究院 | Nutritional drugs pair and its application in preparing tranquilizing and allaying excitement product |
| CN111195333A (en) * | 2020-01-07 | 2020-05-26 | 广州市白云区天芳化妆品厂 | Composition and sleep cream for improving sleep, and preparation method and use method thereof |
-
2009
- 2009-02-16 CN CN200910078094A patent/CN101804148A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056083A (en) * | 2013-03-22 | 2014-09-24 | 张�诚 | Traditional Chinese medicine composition for relieving stress and promoting sleep |
| CN104664371A (en) * | 2015-01-28 | 2015-06-03 | 刘高胜 | Chewable tablets for improving sleeping quality |
| CN106361964A (en) * | 2016-11-11 | 2017-02-01 | 南方医科大学 | Traditional Chinese medicinal composition for improving sleep quality as well as preparation method and application of traditional Chinese medicinal composition |
| CN106361964B (en) * | 2016-11-11 | 2020-08-14 | 南方医科大学 | Traditional Chinese medicine composition for improving sleep quality and preparation method and application thereof |
| CN108720016A (en) * | 2018-06-07 | 2018-11-02 | 中泰宜佳健康科技（北京）有限责任公司 | A kind of mental composition and its preparation method and application that takes good care of one's sight |
| CN108771238A (en) * | 2018-06-28 | 2018-11-09 | 重庆市中药研究院 | Nutritional drugs pair and its application in preparing tranquilizing and allaying excitement product |
| CN111195333A (en) * | 2020-01-07 | 2020-05-26 | 广州市白云区天芳化妆品厂 | Composition and sleep cream for improving sleep, and preparation method and use method thereof |
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Application publication date: 20100818 |