CN102430076A - Umbilici-applied weight-reducing powder - Google Patents

Abstract

The invention relates to weight-reducing pharmaceutical powder and a preparation thereof. Specifically, the weight-reducing pharmaceutical powder is prepared by grinding tuber pinellia, alisma, senna, hawthorn, medicated leaven, astragalus mongholicus, malt, betel palm, atractylis ovata, Citrus aurantium, rhizoma atractylodis and cassia twig according to a certain ratio. When the weight-reducing pharmaceutical powder is used, 3-10 g (increased or decreased according to the state of illness) of the pharmaceutical powder is weighed and mixed with 38-50 degrees of distilled spirit to obtain paste, the paste is prepared into pills, the pills are placed in gauze and applied on the Shenque point (umbilici), a gas-permeable adhesive tape is applied outside for fixing, the application is carried out for 8-12 hours every evening, one course of treatment is one month, and the pharmaceutical powder is forbidden to be used for the women in a menstrual period, the pregnant women and the persons suffering from insufficiency-cold in the spleen and stomach. Through external application, the weight-reducing pharmaceutical powder provided by the invention has a significant curative effect to overweight and obesity caused by phlegm, dampness, deficiency of qi and the like, and has the advantages of convenience for application, definite curative effect, no recurrence, no toxic or side effect, low cost and convenience for wide popularization and application.

Description

A kind of deposited navel applying slimming looses

Technical field

The present invention relates to a kind of drug regimen, specifically is raw material with Chinese medicine, and the fat-reducing of executing the theory preparation of controlling in conjunction with the traditional Chinese medical science acupuncture point Chinese herbs paste that looses belongs to the field of Chinese medicines.

Background technology

Obesity is meant that obvious overweight and fat deposit to a certain degree is blocked up, is body fat, and especially triglyceride gathers a kind of state that too much causes.Owing to food intake too much or the change of organism metabolism cause body fat to gather too much causing excess weight to increase and cause human pathology, physiological change or hide.Along with growth in the living standard; Overweight, problem of obesity becomes the healthy another key factor of harm humans; According to the research report of World Health Organization (WHO), obesity significantly increases the risk of OA in type ii diabetes, gallbladder disease, dyslipidemia, insulin resistant, asthma and the sleep; Make the risk relative risk degree of coronary heart disease, hypertension, osteoarthritis, hyperuricemia and gout, fatty liver increase 2～3 times; Make breast carcinoma after women's menopause, carcinoma of endometrium; Prostate cancer; The colorectal carcinoma meeting, reproductive hormone is unusual, polycystic ovarian syndrome, reproductive function are impaired, the ill risk of back of the body bottom pain and complication of anesthesia increases 1～2 times.And show according to national physique monitoring result in 2010: the overweight obesity rates of being grown up is respectively 32.1%, 9.9%; Adult in 2000 is overweight, obesity rates is respectively 29.12% and 7.27%; Growth in 2005 is 29.25 and 8.04%; The variation of the overweight rate of old people in 60-69 year then is respectively 2000 34.59%, 2005 year 35.63%, 2010 year 39.8%; Obesity rates 2000 10.85%, 2005 year 11.30%, 2010 year 13.0%, has the people of nearly half to be in overweight or fat weight range among China 60-69 year old people.2.98 percentage points of the overweight rate growths of China adult, obesity rates increase by 2.63 percentage points in the period of 10; The old people then increases by 5.21 and 2.15 percentage points respectively.Control in time is overweight, obesity becomes the key issue that guarantees health.

Motherland's medical science sporadically appears in the successive dynasties works to the understanding of obesity." element is asked the logical deficiency and excess opinion of commenting " cloud: " fertile high official, then the disease of fat meat and fine grain also." " element is asked strange sick opinion " meaning: " this person must count the sweet and refreshing and many fertilizer of food also, overeating greasy food bringing about internal heat, over-eating the food with sweet flavor bringing about abdominal distension." explain that the fat cause of disease is a greasy and surfeit flavour.It is too many that fat and heat are taken in, and surpasses to consume, and, endocrine alteration unusual with substance metabolism, living and diet custom and inherited genetic factors etc. are relevant.

At present, common method of weight-reducing has weight reduction with drugs, weight-reducing by dieting, keeps fit through sport, lipposuction, Instrument defatting and Chinese medicine meridian fat-reducing etc.Current about weight reduction with drugs, hormones and multiple catharsis class medicine that Western medicine is is mainly digested and assimilated with amphetamine, increase energy expenditure medicine, the inhibition intestinal of appetite-suppressing.These medicines need be taken mostly for a long time, cost an arm and a leg and have certain toxic and side effects, very easily cause the human body gastrointestinal function disorderly, and bounce-back is more obvious after the drug withdrawal.Diet, motion, Instrument defatting then need patient's willpower and adhering to for a long time firmly, time and effort consuming, and relatively more painful, effect is not remarkable; Though lipposuction can be received effect very soon, wound is big, risk is high; The Chinese medicine meridian fat-reducing mainly is through modes such as acupuncture, massages, need adhere to for a long time that it is not obvious to produce effects.Therefore, seek safe, easy, economy, outstanding effect fat-reducing approach becomes key issue.

And Chinese medicine fat-reducing is because it safe, and side effect is little, and the universality of raw material just increasingly receives pursuing of the patient that loses weight at present.Retrieval is in recent years about fat-reducing type patent of invention; The invention disclosed patent is nearly 700; Wherein Chinese medicine fat-reducing patent is closely half the; For example Chinese patent Granted publication CN1184989C is in the fat-reducing Chinese medicine that acts on degree of Granted publication on January 19th, 2005, is primary raw material with the Radix Astragali, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Poria, Rhizoma Atractylodis, Spina Gleditsiae, Borneolum Syntheticum, Rhizoma Chuanxiong, Rhizoma Alismatis, triangular, Rhizoma Curcumae, Radix Stephaniae Tetrandrae, Herba Asari, Cortex Phellodendri, Fructus Crataegi, Cortex Magnoliae Officinalis, Fructus Aurantii, Folium Sennae; Chinese patent Granted publication CN 1244343C is made up of Folium Ginseng, Flos Rosae Rugosae, Flos Carthami, Fructus Chaenomelis, Rhizoma Chuanxiong, Flos Chrysanthemi, Sargassum, Folium Nelumbinis, Herba Schizonepetae in the Chinese medicine fat-reducing liniment and the method for preparing of Granted publication on March 8th, 2006; One Chinese patent application publication number CN1739657A pastes in the pure Chinese medicine umbilicus of disclosed relieving constipation lowering blood-fat and reducing weight on March 1st, 2006, is that crude drug and accessory drugs are processed by Poria 2-10, Cortex Magnoliae Officinalis 1.5-8, Fructus Aurantii Immaturus 1.5-10, Fructus Cannabis 1.5-9, Radix Et Rhizoma Rhei 1.5-8, Folium Nelumbinis 1.5-8, Fructus Crataegi 1.2-8, Semen Cassiae 1.5-11; Chinese patent Granted publication CN 100387265C is made up of Radix Bupleuri 4-30 part, Pericarpium Citri Reticulatae Viride 6-20 part, Radix Notoginseng 2-10 part, Herba Patriniae 5-20 part, Semen Sojae Preparatum 10-20 part, Rhizoma Atractylodis 5-20 part, Alumen 0.5-1 part and Fructus Ligustri Lucidi 4-20 part in a kind of Chinese medicine preparation of Weight-reducing and lipid-lowering of Granted publication on the 15th May in 2008; One Chinese patent application publication number CN102166292A is that crude drug and accessory drugs fermentation are processed in disclosed a kind of fat-reducing Chinese medicine for outer use and preparation method thereof on August 31st, 2011 by Radix Et Rhizoma Rhei 45-50, Stigma Croci 8-10, Folium Nelumbinis 8-10, Radix Glycyrrhizae 25-30, Borneolum Syntheticum 8-10, Exocarpium Benincasae 8-10, Semen Cassiae 8-10, Aloe 10-15, Radix Aucklandiae 5-6, windproof 8-10, Mel 50-80, tablet vinegar 20-40.

The disclosed various slimming medicines of above patent are different fully with composition and component that deposited navel applying slimming of the present invention looses, and its effect is also different.

Summary of the invention

The inventor sums up prescription handed down from one's ancestors and clinical position experience;, very easily bounce-back not obvious to various fat-reducing effects; The awkward situation of clinical medicine, theoretical in conjunction with Chinese medical theory and modern pharmacy, invented a kind of deposited navel applying slimming and loose; The present invention is made up of the Rhizoma Pinelliae, Rhizoma Alismatis, Folium Sennae, Fructus Crataegi, Massa Medicata Fermentata, the Radix Astragali, Fructus Hordei Germinatus, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Atractylodis and Ramulus Cinnamomi, and its each component consumption is 1: 1.

Method for preparing of the present invention is:

(1) take by weighing the equivalent Rhizoma Pinelliae, Rhizoma Alismatis, Folium Sennae, Fructus Crataegi, Massa Medicata Fermentata, the Radix Astragali, Fructus Hordei Germinatus, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Atractylodis and Ramulus Cinnamomi, with the radioactive element illumination-based disinfection, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;

(2) mixed medicamental pulverata being crossed the bottling of 100～120 mesh sieves seals subsequent use;

Get 3～10g (according to state of an illness increase and decrease) when (3) treating, get 38～50 degree Chinese liquor mediation medicamental pulverata and become pasty state, make piller; Place in the middle of the gauze, stick, the external immobilization with adhesive tape of breathing freely in SHENQUE acupoint (umbilicus); Sticked every night 8～12 hours, be a course of treatment January, menstrual period, anemia of pregnant woman and Deficiency and coldness of spleen and stomach person forbidding.

Specify advantage of the present invention below in conjunction with the property of medicine:

The Rhizoma Pinelliae among the present invention is warm in nature, acrid in the mouth, poisonous; The function that drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass are arranged; Be used for that abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant are dizzy, syncope due to accumulation of phlegm headache, vomiting regurgitation, vexed, the globus hystericus disease of breast gastral cavity painful abdominal mass, antitussive arranged, suppress glandular secretion, the Tuhe, town is emetic, antifertility, to tryptic inhibition and effect such as anticancer; Rhizoma Alismatis sweet in the mouth, light, cold in nature, return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen is arranged, function treating stranguria, blood fat reducing expels the heat-evil.Cure mainly dysuria, the puckery pain of pyretic stranguria, edema distension, have loose bowels, dizziness due to fluid-retention, seminal emission.The Folium Sennae nature and flavor are sweet, bitter, and are cold, slightly poisonous, return large intestine channel.Cure mainly the row that purges heat and stagnate relieving constipation, diuretic.It is stagnant to be used for accumulation of heat, constipation stomachache, edema distension.Fructus Crataegi sour in the mouth, sweet, slightly warm in nature is returned spleen, stomach, Liver Channel.Have effects such as removing food stagnancyization stagnates, convergence dysentery relieving, activating blood circulation to dissipate blood stasis, cure mainly be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, the stasis of blood resistance stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.The Massa Medicata Fermentata bitter in the mouth is warm in nature, returns spleen, stomach warp.The effect of strengthening the spleen to promote digestion, regulating QI to expel dampness are arranged, inducing sweat.Cure mainly the feeling of stuffiness in chest of getting ill from overeating, stomachache is vomited and diarrhoea, dysentery, and headache due to common cold, children's hinders hungry the mistake and satisfies.Radix Astragali sweet in the mouth, slightly warm in nature is returned lung, spleen, liver, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.Fructus Hordei Germinatus sweet in the mouth property is flat, returns spleen, stomach warp.Can promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back newborn relieving distension.Be used for that food stagnation does not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulder, distending pain of the breast, warming the middle warmer and descending qi, change dyspepsia, remove distension, contrary, the expectorant painful abdominal mass of emesis.Semen Arecae bitter in the mouth, suffering, warm in nature, return stomach, large intestine channel.Effect anthelmintic, removing food stagnancy, the therapeutic method to keep the adverse QI flowing downwards, Hang Shui, preventing the attack (or recurrence) of malaria cure mainly weight behind malnutrition due to parasitic infestation, dyspepsia, abdominal distention, the dysentery, beriberi, edema, malaria.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.The function invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for that insufficiency of the spleen lack of appetite, abdominal distention are had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Fructus Aurantii nature and flavor are bitter; Acid; Cold nature is returned lung, spleen, liver, stomach, large intestine channel.Dispelling the stagnated QI, row expectorant, removing food stagnancy function are arranged, cure mainly weight behind septum pectorale feeling of fullness, distending pain over the hypochondrium, accumulation of food in the stomach and intes tine due to indigestion, distension and fullness in the abdomen, the dysentery, proctoptosis, uterine prolapse.Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel.Function is drying damp and strengthening spleen, and expelling wind and cold makes eye bright.Be used to cure mainly distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Ramulus Cinnamomi acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel.The function that diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins are arranged.Cure mainly anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

The traditional Chinese medical science thinks, fat with expectorant, wet, the deficiency of vital energy etc. is relevant, the present invention carries out compatibility with above-mentioned Chinese medicine; Make each medicine produce synergism, set about, utilize the advantage of Chinese medicine from QI invigorating, spleen invigorating, reduce phlegm etc.; Through the method that benefit disappears and rushes down, each organ of adjustment human body recovers original function, and the fat that human body is unnecessary changes into; Recover human energy metabolism, thereby reach the purpose of health slimming, conditioning blood fat.Be in harmonious proportion with Chinese liquor, the SHENQUE acupoint dispenser of the inline twelve regular channels, the vital organs of the human body, extremity bones of the body collectively, five palaces, skin and flesh muscle is chosen in the ventilation of performance Chinese liquor, cold expelling, Shujin, stopping leak, relieve the pain pain, diuresis and anthelmintic effect, is convenient to effective ingredient and absorbs.The present invention sticks through external, operating aspect, and determined curative effect does not rebound, and has no side effect.

The present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation, like pill, powder, capsule etc.

The specific embodiment

Further specify preparation of the present invention below in conjunction with embodiment.

Embodiment one

(1) take by weighing each 3g of the Rhizoma Pinelliae, Rhizoma Alismatis, Folium Sennae, Fructus Crataegi, Massa Medicata Fermentata, the Radix Astragali, Fructus Hordei Germinatus, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Atractylodis and Ramulus Cinnamomi, with the radioactive element illumination-based disinfection, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;

(2) mixed medicamental pulverata being crossed the bottling of 100～120 mesh sieves seals subsequent use;

Get 3g medicamental pulverata (according to state of an illness increase and decrease) when (3) treating, get 38 degree Chinese liquor mediation medicamental pulverata and become pasty state, make piller; Place in the middle of the gauze, stick, the external immobilization with adhesive tape of breathing freely in SHENQUE acupoint; Sticked every night 8～12 hours, be a course of treatment January, menstrual period, anemia of pregnant woman and Deficiency and coldness of spleen and stomach person forbidding.

Embodiment two

(1) take by weighing each 6g of the Rhizoma Pinelliae, Rhizoma Alismatis, Folium Sennae, Fructus Crataegi, Massa Medicata Fermentata, the Radix Astragali, Fructus Hordei Germinatus, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Atractylodis and Ramulus Cinnamomi, with the radioactive element illumination-based disinfection, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;

(2) mixed medicamental pulverata being crossed the bottling of 100～120 mesh sieves seals subsequent use;

Get 10g medicamental pulverata (according to state of an illness increase and decrease) when (3) treating, get 50 degree Chinese liquor mediation medicamental pulverata and become pasty state, make piller; Place in the middle of the gauze, stick, the external immobilization with adhesive tape of breathing freely in SHENQUE acupoint; Sticked every night 8～12 hours, be a course of treatment January, menstrual period, anemia of pregnant woman and Deficiency and coldness of spleen and stomach person forbidding.

Test Example 1 the present invention diffusing acute toxicity test of losing weight

Acute toxicity test: choose each 10 of normal skin and artificial damaged skin SD rats, stick 5 times of (15g/kg body weight) infant quick-acting defervescents respectively and loose, repeatedly stick, skin allergy and toxicity all do not occur.

Test Example 2

One, physical data

1, patient source: case 180 examples are observed in this test altogether, wherein concurrent hyperlipidemia 40 examples, and concurrent fatty liver 20 examples, concurrent hypertension, 30 examples, concurrent diabetes 10 examples are divided into test group and matched group.

Test group sticks the present invention and loses weight diffusingly, sticks every night 8～12 hours, and be a course of treatment January, 3 courses of treatment of continuous use; The refined orlistat capsule of moulding that observation group selects for use Chongqing Watson Pharmaceutical Co., Ltd to produce.

Two, include the case standard in

Body Mass Index (BMI) >=24.

Three, test method

Matched group, the refined of the oral Chongqing Watson Pharmaceutical Co., Ltd of 1h production after the meal moulded the orlistat capsule 120mg/ time, once-a-day, takes 3 months; Test group sticks the present invention and loses weight diffusingly, sticks every night 8～12 hours, and be a course of treatment January, 3 courses of treatment of continuous use.Do not change situation such as original diet, motion before and after the medication.Observe two groups of variation and untoward reaction such as body weight, waistline, chest measurement, hip circumference and blood fat after the medication respectively.

Four, evaluation criterion:

Weight loss＞5kg is that effect is remarkable, and weight loss＞3kg is that effectively decline＜3kg is invalid.

Five, result

1. two groups of comprehensive therapeutic effects, weight loss significantly accounts for 46.7% (42 example), effective 38.9% (35 example), invalid 14.4% (13 example), total effective rate 85.6% after the matched group medication; Weight loss significantly accounts for 56.7% (51 example), effective 41.1% (37 example), invalid 2.2% (2 example), total effective rate 97.8% after the test group medication; 2 centimetres of matched group waistline decreased average, 1.8 centimetres of chest measurements, 2.3 centimetres of hip circumferences, 3.2 centimetres of test group waistline decreased average, 2.2 centimetres of chest measurements, 2.5 centimetres of hip circumferences.Main variation is as shown in table 1 before and after blood fat, the blood glucose treatment.

Main variation

before and after table 1 blood fat, the blood glucose treatment

Detect index	Before the treatment (mmol/l)	After the treatment of control group (mmol/l)	Test group treatment back (mmol/l)
				T-CHOL	8.51±1.32	5.41±1.06	5.16±1.13
Triglyceride	4.61±0.41	2.01±0.30	1.95±0.36
				High density lipoprotein	1.03±0.31	1.15±0.38	1.19±0.35
Low density lipoprotein, LDL	3.95±0.61	3.35±0.47	3.05±0.43
				Fasting glucose	8.46±0.31	6.36±0.46	6.01±0.33

After table 1 shows the diffusing treatment of fat-reducing of the present invention; Overweight people's T-CHOL, triglyceride, high density lipoprotein, low density lipoprotein, LDL, fasting glucose etc. all have obvious decline, and be respond well, and be superior to the refined orlistat capsule of moulding; Cheap, be convenient to extensive popularization, application.

Six, conclusion

180 routine clinical test results show, loose overweight, obesity that treatment expectorant, wet, the deficiency of vital energy etc. are caused of this kind fat-reducing has significant curative effect, and its symptomes complice curative effect total effective rate is respectively 97.8%.Comprehensive this Chinese powder medicine determined curative effect of contrast, application is convenient, and in application process, does not find obvious adverse reaction and toxic and side effects.

Claims (4)

1. a deposited navel applying slimming looses, and it is characterized in that it is to be developed by the Rhizoma Pinelliae, Rhizoma Alismatis, Folium Sennae, Fructus Crataegi, Massa Medicata Fermentata, the Radix Astragali, Fructus Hordei Germinatus, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Atractylodis and the Ramulus Cinnamomi crude drug that wait weight portion.

2. the said fat-reducing of claim 1 method for preparing of loosing, it comprises the following steps:

A) take by weighing the equivalent Rhizoma Pinelliae, Rhizoma Alismatis, Folium Sennae, Fructus Crataegi, Massa Medicata Fermentata, the Radix Astragali, Fructus Hordei Germinatus, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Atractylodis and Ramulus Cinnamomi, with the sterilization of radioactive element cobalt irradiation, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;

B) mixed medicamental pulverata being crossed the bottling sealing of 100～120 mesh sieves, subsequent use promptly get the described fat-reducing of claim 1 diffusing;

3. loose according to fat-reducing described in the claim 1 and 2, get 3～10g (according to state of an illness increase and decrease) during treatment, get 38～50 degree Chinese liquor mediation medicamental pulverata and become pasty state; Make piller, place in the middle of the gauze, stick in SHENQUE acupoint (umbilicus); The external immobilization with adhesive tape of breathing freely; Sticked every night 8～12 hours, be a course of treatment January, menstrual period, anemia of pregnant woman and Deficiency and coldness of spleen and stomach person forbidding.

4. according to claim 1 or 3 described medicines, process increases adjuvant, can process to stick, and is widely used.