CN102847075B - Medicine composition for treating insomnia - Google Patents
Medicine composition for treating insomnia Download PDFInfo
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- CN102847075B CN102847075B CN201210368795.2A CN201210368795A CN102847075B CN 102847075 B CN102847075 B CN 102847075B CN 201210368795 A CN201210368795 A CN 201210368795A CN 102847075 B CN102847075 B CN 102847075B
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Abstract
The invention relates to medicine composition for treating insomnia, which consists of following ingredients in parts by weight: 15 to 35 parts of Chinese angelica, 10 to 30 parts of roots of red-rooted salvia, 15 to 30 parts of radix curcumae, 10 to 25 parts of polygala tenuifolia, 5 to 23 parts of liquorice, 10 to 28 parts of poria with hostwood, 15 to 33 parts of fried spina date seeds, 1 to 15 parts of fructus alpiniae oxyphyllae, 5 to 23 parts of pericarpium citri reticulatae, 4 to 22 parts of platycladi seeds, 6 to 24 parts of calamus, 5 to 23 parts of dragon bone, 15 to 33 parts of rheum officinale, 1 to 15 parts of ligusticum wallichii, 2 to 18 parts of schisandra chinensis, 5 to 23 parts of radix paeoniae alba, 2 to 18 parts of Cape jasmine, 10 to 28 parts of cortex albiziae, 0.4 to 0.7 part of propranolol hydrochloride, 0.4 to 0.7 part of oryzanol and 0.2 to 0.3 part of diazepam tablets. The medicine composition has a function for treating nervous insomnia caused by various reasons, refractory insomnia and insomnia with unknown reasons; and moreover, the medicine composition is remarkable in curative effect, short in treatment process, fast in effectiveness and free from side effect.
Description
Technical field
The present invention relates to a kind of Pharmaceutical composition of Cure for insomnia.
Background technology
Insomnia is larger to the harm of health, and its Symptoms is difficulty falling asleep or awake frequent, dreaminess, and without sleep sense, sleep not dark and early awakening, do not recover from fatigue after waking up etc.From traditional Chinese medical science angle, the reason of insomnia mainly contains in stagnation of QI due to depression of the liver, expectorant heat and disturbs, hyperactivity of fire caused by deficiency of YIN, deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy.At present, in Cure for insomnia, Western medicine is of a great variety, but there are the following problems: 1, western medicine instant effect, but Chang Fanfu, and very strong to drug dependence after life-time service, cure the symptoms, not the disease; 2, the curative effect of the relative Western medicine of Chinese medicine is slower, and mostly existing prescription be for one or more treatments in above-mentioned insomnia reason, insomniac before determining insomnia reason, medication easily, otherwise incur loss through delay, even increase the weight of the state of an illness.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Pharmaceutical composition of Cure for insomnia, the nerve insomnia that a variety of causes is caused, intractable insomnia and unknown cause insomnia all have therapeutical effect, and evident in efficacy, short treating period, instant effect, is free from side effects.
Technical scheme of the present invention is:
A Pharmaceutical composition for Cure for insomnia, its special character is to consist of in parts by weight:
Radix Angelicae Sinensis 15-35 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Curcumae 15-30 part, Radix Polygalae 10-25 part, Radix Glycyrrhizae 5-23 part, Poria cum Radix Pini 10-28 part, Semen Ziziphi Spinosae (parched) 15-33 part, Fructus Alpiniae Oxyphyllae 1-15 part, Pericarpium Citri Reticulatae 5-23 part, Semen Platycladi 4-22 part, Shi Mao Pu 6-24 part, Os Draconis 5-23 part, Radix Et Rhizoma Rhei 15-33 part, Rhizoma Chuanxiong 1-15 part, Fructus Schisandrae Chinensis 2-18 part, Radix Paeoniae Alba 5-23 part, Fructus Gardeniae 2-18 part, Cortex Albiziae 10-28 part, propranolol hydrochloride 0.4-0.7 part, paddy gourmet powder 0.4-0.7 part, Western sheet 0.2-0.3 part.
The Pharmaceutical composition of above-mentioned Cure for insomnia, dosage form is honeyed pill.
In this Pharmaceutical composition, the effect of each component is as follows:
Radix Angelicae Sinensis: acrid-sweet flavor, warm in nature, the effect that having enriches blood invigorates blood circulation;
Radix Salviae Miltiorrhizae: bitter in the mouth, warm in nature cold, removing heat from blood detumescence, the relieving restlessness that clears away heart-fire, can control carbuncle sore tumefacting virus, rheumatism pyretic arthralgia and dysphoria and insomnia;
Radix Curcumae: dispersing the stagnated live-QI to relieve the stagnation of QI, the removing heat from blood that clears away heart-fire, turbid for hygropyrexia expectorant, hoodwink the obnubilation of key clearly, the crazy grade of epilepsy disease;
Radix Polygalae: be good at treating the diseases such as heart beating uneasiness, insomnia, play the effect of the relieving palpitation of calming the nerves, and control forgetfully, can strengthen man memory power;
Radix Glycyrrhizae: coordinating the actions of various ingredients in a prescription, process warming middle-JIAO, raw pathogenic fire purging, this component is processed with the kind warming and invigorating the spleen and stomach of function, QI invigorating invigorating middle warmer, the gas that can nourish heart, spasmolytic is throbbed with fear and lung moistening;
Poria cum Radix Pini, Semen Ziziphi Spinosae (parched), Semen Platycladi, Fructus Alpiniae Oxyphyllae: there is tranquilizing mind, the kidney invigorating gas, the blood of the liver of nourishing heart and except fidgets due to deficiency, thus there is the clearing away liver-fire of calming the nerves, the kind heart beating uneasiness of controlling, insomnia and insobriety, except malaise, the effect of anger vexation;
Pericarpium Citri Reticulatae: have regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm, is used for middle gas discord and the diseases such as the abdominal distention uncomfortable in chest that occurs, vomiting, dim gas, inappetence, abundant expectoration cough;
Shi Mao Pu: the dry temperature of pungent loose hardship is logical, has the effect wet, happy key of eliminating the phlegm, the kind phlegm-damp of controlling is hoodwinked the mind narco of thinking, uncomfortable in chestly the disease such as is not eaten;
Os Draconis: can suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion is also controlled because of infantile convulsion, hyperactivity of YANG due to deficiency of YIN, fidgety irritability that wind heat causes, is had a dizzy spell and mind is uneasy, palpitation with fear insomnia;
Radix Et Rhizoma Rhei: can remove intestinal sthenia gastropyrexia, have and attack effect stagnant, expectorant water flowing;
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, pungent energy is loose, and Wen Nengtong, so it has the effect of blood-activating and qi-promoting, wind-expelling pain-stopping;
Fructus Schisandrae Chinensis: have nourishing kidney tonifying the lung, the effect of promoting the production of body fluid to quench thirst;
Radix Paeoniae Alba: have convergence and the effect of replenishing YIN and blood, this component has that liver-yin, suppressing liver-YANG are held back in acid, the effect of the easing the affected liver of enriching blood;
Fructus Gardeniae: be good at the heat of pathogenic fire purging clearly, the relieving restlessness that clears away heart-fire, can remove hot and suffocating in the heart vexed uneasiness, and energy cooling blood for hemostasis, can also control stomach burning pain;
Cortex Albiziae: the diseases such as the anger causing for damaged by excess of seven emotions, melancholy, dysphoria, forgetful insomnia.
Propranolol hydrochloride (existing commodity propranolol by name): coordinate clinically anxiety, down treatment to show as anxiety neurosis, the phobia that heart is nervous, upset, worry, fear in terror, have a sleepless night, lack of proper care with autonomic nervous function.
Paddy gourmet powder: mainly improve autonomic nervous dysfunction, improve incretion balance obstacle and spiritual nervous disorder, therefore neurasthenia patient is had to certain regulating action; While energy stabilizing the emotions, anxiety reduction and tense situation, and improve sleep.
The Western sheet in ground: there is anxiety, sedative-hypnotic effect.
After drug storage compatibility, three taste western medicine component (propranolol hydrochlorides wherein, paddy gourmet powder, the Western sheet in ground) mainly in treatment, play the effect of quickening drug effect early stage, 18 taste Chinese medicinal components are fundamentally removed source of disease, thereby reach regulating menstruation along arteries and veins, the QI invigorating of calming the nerves, kind relieving convulsionly throb with fear, hemopoietic reinforcing the heart, QI and blood regulating, settling five organs, resolving depression soothing liver-QI and blood-enriching tranquillizing, to dimly forgetful, timidness due to deficiency of the heart, psychasthenia, fidgety dreaminess and a variety of causes insomnia have therapeutical effect, not only take stopgap measures but also effect a permanent cure, evident in efficacy, instant effect, after 7 days, be clearly better, within 1 month～bis-months, can cure, the state of an illness is not repeatedly, and be free from side effects.
The specific embodiment
Embodiment 1
A Pharmaceutical composition for Cure for insomnia, consists of: 35 grams of Radix Angelicae Sinensis, 12 grams of Radix Salviae Miltiorrhizaes, 30 grams of Radix Curcumaes, 12 grams of Radix Polygalaes, 23 grams, Radix Glycyrrhizae, 12 grams of Poria cum Radix Pinis, 33 grams of Semen Ziziphi Spinosae (parched)s, 2 grams of Fructus Alpiniae Oxyphyllae, 23 grams of Pericarpium Citri Reticulataes, 24 grams of 6 grams of ， Shi Mao Pus of Semen Platycladi, 7 grams of Os Draconis, 33 grams of Radix Et Rhizoma Rhei, 2 grams of Rhizoma Chuanxiongs, 18 grams of Fructus Schisandrae Chinensis, 7 grams of Radix Paeoniae Alba, 18 grams of Fructus Gardeniaes, 12 grams of Cortex Albiziaes, 700 milligrams of propranolol hydrochlorides, 700 milligrams of paddy gourmet powders, 300 milligrams of the West, ground sheets.Wherein, propranolol hydrochloride adopts 70 of the dosage of commercially available 10 milligrams of a slices, and paddy gourmet powder adopts 70 of the dosage of commercially available 10 milligrams of a slices, and the West, ground sheet adopts 120 of the dosage of commercially available 2.5 milligrams of a slices.
Be made into the method for pill: 1,, by above-mentioned each component pulverize, mix and stir; 2, the Mel of (guarantee the quality time long) of heating being anhydrated is poured medicated powder after stirring into and is become dough shape, and the weight of Mel is 291 grams; 3, dough is cut into the fritter honeyed pill of 6 grams of left and right, makes altogether 100 balls, packing.
Method of administration: one, next sky of normal condition, within when the state of an illness is heavier first 3 days-7 days, be increased to two of every days, before sleeping, take half an hour.
Embodiment 2
A Pharmaceutical composition for Cure for insomnia, consists of: 18 grams of Radix Angelicae Sinensis, 30 grams of Radix Salviae Miltiorrhizaes, 17 grams of Radix Curcumaes, 25 grams of Radix Polygalaes, 7 grams, Radix Glycyrrhizae, 28 grams of Poria cum Radix Pinis, 17 grams of Semen Ziziphi Spinosae (parched)s, 15 grams of Fructus Alpiniae Oxyphyllae, 7 grams of Pericarpium Citri Reticulataes, 8 grams of 22 grams of ， Shi Mao Pus of Semen Platycladi, 23 grams of Os Draconis, 17 grams of Radix Et Rhizoma Rhei, 15 grams of Rhizoma Chuanxiongs, 4 grams of Fructus Schisandrae Chinensis, 23 grams of Radix Paeoniae Alba, 4 grams of Fructus Gardeniaes, 28 grams of Cortex Albiziaes, 400 milligrams of propranolol hydrochlorides, 400 milligrams of paddy gourmet powders, 200 milligrams of the West, ground sheets.Wherein, propranolol hydrochloride adopts 40 of the dosage of commercially available 10 milligrams of a slices, and paddy gourmet powder adopts 40 of the dosage of commercially available 10 milligrams of a slices, and the West, ground sheet adopts 80 of the dosage of commercially available 2.5 milligrams of a slices.
Be made into the method for pill: 1,, by above-mentioned each component pulverize, mix and stir; 2, the Mel of (guarantee the quality time long) of heating being anhydrated is poured medicated powder after stirring into and is become dough shape, and Mel addition is 292 grams; 3, dough is cut into the fritter honeyed pill of 6 grams of left and right, makes altogether 100 balls, packing.
Instructions of taking is with embodiment 1.
Embodiment 3
A Pharmaceutical composition for Cure for insomnia, consists of: 25 grams of Radix Angelicae Sinensis, 20 grams of Radix Salviae Miltiorrhizaes, 25 grams of Radix Curcumaes, 20 grams of Radix Polygalaes, 15 grams, Radix Glycyrrhizae, 20 grams of Poria cum Radix Pinis, 25 grams of Semen Ziziphi Spinosae (parched)s, 10 grams of Fructus Alpiniae Oxyphyllae, 15 grams of Pericarpium Citri Reticulataes, 16 grams of 14 grams of ， Shi Mao Pus of Semen Platycladi, 15 grams of Os Draconis, 25 grams of Radix Et Rhizoma Rhei, 8 grams of Rhizoma Chuanxiongs, 10 grams of Fructus Schisandrae Chinensis, 15 grams of Radix Paeoniae Alba, 10 grams of Fructus Gardeniaes, 20 grams of Cortex Albiziaes, 500 milligrams of propranolol hydrochlorides, 500 milligrams of paddy gourmet powders, 250 milligrams of the West, ground sheets.Wherein, propranolol hydrochloride adopts 50 of the dosage of commercially available 10 milligrams of a slices, and paddy gourmet powder adopts 50 of the dosage of commercially available 10 milligrams of a slices, and the West, ground sheet adopts 100 of the dosage of commercially available 2.5 milligrams of a slices.
Be made into the method for pill: 1,, by above-mentioned each component pulverize, mix and stir; 2, the Mel of (guarantee the quality time long) of heating being anhydrated is poured medicated powder after stirring into and is become dough shape, and the weight of Mel is 292 grams; 3, dough is cut into the fritter honeyed pill of 6 grams of left and right, makes altogether 100 balls, packing.
Method of administration: one day one (be in a bad way patient first 3 days～7 days one day two), before sleeping, half an hour～mono-hour takes, and taking medicine one month is a course for the treatment of.
This Pharmaceutical composition is through 200 routine clinical treatments.Wherein there are 60 routine nerve insomnias, 100 routine intractable insomnia, 40 routine unknown cause insomnias.
Nerve insomnia concrete manifestation: psychentonia.Even if responsive falling asleep easily waken up with a start especially, cannot fall asleep.
Intractable insomnia concrete manifestation: difficulty falling asleep, dreaminess, shallow sleep, vexed, irritability, disease are changeable.
Unknown cause insomnia concrete manifestation: fidgets due to deficiency, insomnia, palpitation with fear, dreaminess, body void, hyperhidrosis, even lie awake all night.
After taking medicine 7 days, symptom takes an evident turn for the better, and takes medicine after the course for the treatment of, and can reach more than 5 hours the length of one's sleep the whole night, and sleep quality is all deep sleep, corresponding disease, number of cases and after the course for the treatment of effective percentage see the following form:
| ? | Columns | Recovery from illness | Effectively | Invalid | Total effective rate % |
| Nerve insomnia | 60 | 20 | 36 | 4 | 93.3% |
| Intractable insomnia | 100 | 38 | 56 | 6 | 94% |
| Unknown cause insomnia | 40 | 16 | 22 | 2 | 95% |
Now providing for example representational three cases is illustrated:
1, nerve insomnia: Liaoyang Shou Shan, Han Hong, female, 53 years old, teacher.Ill 10 years, be repeatedly admitted to hospital, be diagnosed as neurasthenia, with anxiety, have a guilty conscience, anxious, insomnia and dreamful sleep, sleep is the whole night no more than 3 hours at most, with a haggard face, without appetite.It is taken before this medicine, adheres to taking oryzanol every day, mix in chlorine nitre west, attempts transfusion, acupuncture, oral drugs between hospitalized period, does not all feel any better.From in January, 2012, start to take this medicine.In view of it is in a bad way, before sleeping every night, take two pills half an hour, and after three days, the state of an illness is alleviated, and sleep improves, and sleep reaches 4-5 hour, and has realized deep sleep.Then, according to its state of an illness, change one day 1 pill into, before sleeping every night, after half an hour, take.Within 7 days, sleep and obtained good improvement afterwards, substantially reach ortho sleep 6-7 hour every night.Take after the course for the treatment of, ortho sleep is 7-8 hour every night, now drug withdrawal 6 months, and the state of an illness has no repeatedly.
2, unknown cause insomnia: Benxi, Hu Miaoli, female, 63 years old, suffer from insomnia more than 2 years, be once admitted to hospital twice, before sleeping evening, take 2 of Western medicine oryzanol, chlorine nitre west is mixed 4 and just can be fallen asleep about 3 hours, the symptoms such as occurring dizziness, headache, myasthenia of limbs of waking up morning.Introduce in March, 2012 through other patients, takes this medicine, first 3 days doses of medication be before sleeping evening half an hour take two pills, then change into sleep before half an hour take medicine, 7 days afterwards sleep be greatly improved, natural sleep, naturally awake.And head is bitterly not dizzy, no longer weak yet.A whole night, deep sleep reached 5-7 hour.Take after the course for the treatment of, sleep is normal, now drug withdrawal, and nothing is repeatedly.
3, intractable insomnia: Benxi, Huang Guoshi, man, 79 years old, the retired cadre of mineral bureau, insomniac more than 30 years, to be repeatedly admitted to hospital, many places are sought doctor's inquiring and are had no curative effect, and the length of one's sleep is at 2-3 hour, shallow sleep, dreaminess, go toilet just to urinate 5-10 time an evening, suffers untold misery.Through other patients, introduce, on June 20th, 2012 starts to take this medicine, and the first 7 days dosages of taking medicine are to sleep evening to take two pills in first 1 hour, reach 2-4 hour the length of one's sleep, just urinate 2-3 time every night, and after going to toilet, still can continue to sleep soundly.Take medicine after 7 days, sleep every night and take a pill in first 1 hour, take after the course for the treatment of, sleep state has obtained significantly improving, and the 5-6 hour that can sleep every night, just urinates number of times and be reduced to 1-2 time.Consolidate after the course for the treatment of, existing with drug withdrawal, the state of an illness is without repeatedly.
Claims (2)
1. a Pharmaceutical composition for Cure for insomnia, is characterized in that, in parts by weight, consists of:
Radix Angelicae Sinensis 15-35 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Curcumae 15-30 part, Radix Polygalae 10-25 part, Radix Glycyrrhizae 5-23 part, Poria cum Radix Pini 10-28 part, Semen Ziziphi Spinosae (parched) 15-33 part, Fructus Alpiniae Oxyphyllae 1-15 part, Pericarpium Citri Reticulatae 5-23 part, Semen Platycladi 4-22 part, Rhizoma Acori Graminei 6-24 part, Os Draconis 5-23 part, Radix Et Rhizoma Rhei 15-33 part, Rhizoma Chuanxiong 1-15 part, Fructus Schisandrae Chinensis 2-18 part, Radix Paeoniae Alba 5-23 part, Fructus Gardeniae 2-18 part, Cortex Albiziae 10-28 part, propranolol hydrochloride 0.4-0.7 part, oryzanol 0.4-0.7 part, Western sheet 0.2-0.3 part.
2. the Pharmaceutical composition of Cure for insomnia according to claim 1, is characterized in that dosage form is honeyed pill.
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| CN201210368795.2A CN102847075B (en) | 2012-09-27 | 2012-09-27 | Medicine composition for treating insomnia |
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| CN201210368795.2A CN102847075B (en) | 2012-09-27 | 2012-09-27 | Medicine composition for treating insomnia |
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| CN103877199A (en) * | 2013-12-10 | 2014-06-25 | 济南新起点医药科技有限公司 | Traditional Chinese medicine composition for treating insomnia caused by fire excess from yin deficiency |
| CN103977342A (en) * | 2014-03-24 | 2014-08-13 | 济南伟传信息技术有限公司 | Tranquilizing medicine for color Doppler ultrasound |
| CN104001067A (en) * | 2014-06-10 | 2014-08-27 | 滕秀君 | Traditional Chinese medicine composition for curing intractable insomnia |
| CN106511518A (en) * | 2016-11-30 | 2017-03-22 | 上海市浦东新区肺科医院 | Traditional Chinese medicine composition with effects of soothing nerves and aiding sleep |
| CN112755074B (en) * | 2021-01-21 | 2022-02-11 | 上海普康药业有限公司 | Pharmaceutical composition containing oryzanol and preparation method and application thereof |
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| CN1059110C (en) * | 1997-05-27 | 2000-12-06 | 岳云春 | Compound oral liquid medicine for treating psychosis and nerve system disease |
| CN1294004A (en) * | 1999-10-29 | 2001-05-09 | 武常流 | Chinese patent medicine for taking care of brain health |
| CN100356976C (en) * | 2004-09-27 | 2007-12-26 | 程银胜 | Formula group for treating stomach and intestine neurosis and gastritis |
| CN1736449A (en) * | 2005-08-08 | 2006-02-22 | 黄开启 | Powder for climacteric syndrome and its preparing process |
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