CN106215019A - A kind of processing technology of refined even stomatitis spray - Google Patents

A kind of processing technology of refined even stomatitis spray Download PDF

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Publication number
CN106215019A
CN106215019A CN201610795045.1A CN201610795045A CN106215019A CN 106215019 A CN106215019 A CN 106215019A CN 201610795045 A CN201610795045 A CN 201610795045A CN 106215019 A CN106215019 A CN 106215019A
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parts
ethanol
weight
heated
refined
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严光玉
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HONGYA WAWUSHAN PHARMACEUTICAL Co Ltd
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HONGYA WAWUSHAN PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
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Abstract

The invention discloses the processing technology of a kind of refined even stomatitis spray, weigh by following part by weight: 35 parts of refined company, 12 parts of Folium Bambusae, Caulis Akebiae 12 parts, Radix Rehmanniae 1.5 3 parts, 0.5 1 parts of Radix Glycyrrhizae, Radix Scutellariae 12 parts, Herba Menthae 12 parts, by 75% soak with ethanol more than 24 hours of 5 times of weight after merging, being then heated to seethe with excitement 30 60 minutes, filter, filtering residue is heated to boiling with 75% ethanol of 3 times of weight again and extracts 23 times, merging filtrate, filtrate distillation being removed ethanol, adds boric acid after cooling, the addition of boric acid is 3 4g/L.Refined even stomatitis spray prepared by the method using the present invention, raw material through scientific compatibility, synergism, has heat-clearing and toxic substances removing, relieving spasm to stop pain, the stomatitis that particularly causes high sugar have the curative effect of uniqueness.

Description

A kind of processing technology of refined even stomatitis spray
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to the processing technology of a kind of refined even stomatitis spray.
Background technology
Diabetes are one group of lifelong participation metabolic diseases being characterized with chronic hyperglycemia caused by multi-pathogenesis.Long-term blood Sugar increases, and big blood vessel, blood capillary are impaired and jeopardize the heart, brain, kidney, peripheral nerve, eyes, foot etc., adds up according to World Health Organization (WHO), Diabetic complication is up to kind more than 100, is to be currently known a kind of disease that complication is most.Diabetes Death person has more than half Being caused by cardiovascular and cerebrovascular vessel, 10% is caused by nephropathy.Because the patient of diabetes amputation is ND 10～20 times.Clinical number According to display, after onset diabetes about 10 years, there is a kind of complication, and complication to I haven't seen you for ages by there being the patient of 30%～40% Once producing, Drug therapy is difficult to reverse, and therefore emphasizes to prevent diabetic complication as early as possible.
Diabetes easily cause conscience heated, consume impairment of YIN blood group, and Symptoms is: being irritable and getting angry easily, distending pain over the hypochondrium or dull pain, Bitter taste is thirsty, Facial flush, palpitation and insomnia, aphtha of the mouth and tongue, Hiccough and deaf, blurring of vision, measures many through row or measures few, red tongue with yellow fur Or lack tongue, wiry and frequent pulse or stringy and thready pulse number.
The aphtha of the mouth and tongue caused for diabetes, the existing medicine for common aphtha of the mouth and tongue is difficult to work, and this is After destroying due to diabetes patient local mucosa, due to high sugar, the most resistance to healing.
Summary of the invention
The present invention seeks to the processing technology of a kind of refined even stomatitis spray, solve what diabetes patient's stomatitis was difficult to cure Problem.
The technical scheme is that the processing technology of a kind of refined even stomatitis spray, weigh by following part by weight: refined Even 3-5 part, Folium Bambusae 1-2 part, Caulis Akebiae 1-2 part, Radix Rehmanniae 1.5-3 part, Radix Glycyrrhizae 0.5-1 part, Radix Scutellariae 1-2 part, Herba Menthae 1-2 part, close By 75% soak with ethanol more than 24 hours of 5 times of weight after and, being then heated to boiling 30-60 minute, filtration, filtering residue is again with 3 75% ethanol of times weight is heated to boiling and extracts 2-3 time, merging filtrate, and filtrate distillation is removed ethanol, addition boron after cooling Acid, the addition of boric acid is 3-4g/L.
Further, weigh by following part by weight: 4 parts of refined company, 1.5 parts of Folium Bambusae, Caulis Akebiae 1.5 parts, Radix Rehmanniae 2 parts, sweet Grass 0.8 part, Radix Scutellariae 1.5 parts, Herba Menthae 1.5 parts.
Further, by 75% soak with ethanol more than 24 hours of 5 times of weight after merging, it is then heated to seethe with excitement 45 points Clock, filters, and filtering residue is heated to boiling with 75% ethanol of 3 times of weight again and extracts 3 times, merging filtrate.
The primary medicinal component berberine of refined company can promote that insulin releasing increases, and suppresses gluconeogenesis, promotes glycolysis, Having the regeneration function promoting beta Cell of islet, its mechanism of action is not direct blood sugar lowering simultaneously, but fundamentally solves human body pancreas The problem that island element lacks.
Folium Bambusae is the leaf of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, effect: clearing heat and relieving fidgetness, diuresis of promoting the production of body fluid.Cure mainly: control calentura excessive thirst, children's Infantile convulsion, cough with dyspnea tells nosebleed, flushed complexion, oliguria with reddish urine, erosion of the oral mucosa tongue boil.
Caulis Akebiae, Chinese medicine name.For plants of Lardizabalaceae Caulis Akebiae Akebia quinata (Thunb.) Decne., threeleaf akebia Akebia tri foliata (Thunb.) Koidz. or Caulis Akebiae Akebia tri oliata (Thunb.) The dry rattan of Koidz.ar.australis (Diels) Rehd..Function: have inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness, stimulating milk secretion of stimulating the menstrual flow Effect.Cure mainly: for stranguria, edema, vexed dark coloured urine, aphtha of the mouth and tongue, amenorrhea breast is few, damp and hot arthralgia pain.
Radix Rehmanniae, effect: clearing away heat and promoting production of body fluid YIN nourishing, nourishes blood.Cure mainly: control fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, the moon Through uncomfortable, frequent fetal movement, the moon hinders constipation.
Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.It is usually used in taste Weakness, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Scutellariae, bitter in the mouth, cold in nature, there are heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly epidemic febrile disease, upper breathing The diseases such as road infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Herba Menthae, dispelling wind and heat pathogens, the clear profit head, sore-throat relieving rash, soothing the liver circulation of qi promoting.Cure mainly: affection due to external wind and heat, headache, laryngopharynx swelling and pain, Dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease is from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
Boric acid is external antibacterial, disinfectant, astringent and preservative.Various bacteria, mycete all there is inhibitory action.Make It is that it can be combined with the amino in bacterioprotein and plays a role by principle.Can be used for skin, mucosa, wound, oral cavity, the moon The irrigation and disinfection such as road, bladder it can also be used to otitis, burn, scald, eczema etc..
The present invention compared with prior art has the advantage that
Refined even stomatitis spray prepared by the method using the present invention, raw material, through scientific compatibility, synergism, has heat clearing away Removing toxic substances, relieving spasm to stop pain, the stomatitis that particularly causes high sugar have the curative effect of uniqueness.
Detailed description of the invention
Embodiment 1
The processing technology of a kind of refined even stomatitis spray, is weighed by following part by weight: 3 parts of refined company, 1 part of Folium Bambusae, Caulis Akebiae 1 Part, Radix Rehmanniae 1.5 parts, 0.5 part of Radix Glycyrrhizae, Radix Scutellariae 1 part, Herba Menthae 1 part, by 75% soak with ethanol 24 hours of 5 times of weight after merging Above, being then heated to seethe with excitement 30 minutes, filter, filtering residue is heated to boiling with 75% ethanol of 3 times of weight again and extracts 3 times, closes And filtrate, ethanol to be removed in filtrate distillation, after cooling, adds boric acid, the addition of boric acid is 3g/L.
Embodiment 2
The processing technology of a kind of refined even stomatitis spray, is weighed by following part by weight: 5 parts of refined company, 2 parts of Folium Bambusae, Caulis Akebiae 2 Part, Radix Rehmanniae 3 parts, 1 part of Radix Glycyrrhizae, Radix Scutellariae 2 parts, Herba Menthae 2 parts, by 75% soak with ethanol more than 24 hours of 5 times of weight after merging, Being then heated to seethe with excitement 60 minutes, filter, filtering residue is heated to boiling with 75% ethanol of 3 times of weight again and extracts 2 times, merges filter Liquid, removes ethanol by filtrate distillation, adds boric acid after cooling, and the addition of boric acid is 4g/L.
Embodiment 3
The processing technology of a kind of refined even stomatitis spray, is weighed by following part by weight: 4 parts of refined company, 1.5 parts of Folium Bambusae, wood Logical 1.5 parts, Radix Rehmanniae 2 parts, 0.8 part of Radix Glycyrrhizae, Radix Scutellariae 1.5 parts, Herba Menthae 1.5 parts.By 75% soak with ethanol of 5 times of weight after merging More than 24 hours, being then heated to seethe with excitement 45 minutes, filter, filtering residue is heated to, with 75% ethanol of 3 times of weight, extraction 3 of seething with excitement again Secondary, merging filtrate.Filtrate distillation being removed ethanol, adds boric acid after cooling, the addition of boric acid is 3.5g/L.
Embodiment described above only have expressed the detailed description of the invention of the application, and it describes more concrete and detailed, but also Therefore the restriction to the application protection domain can not be interpreted as.It should be pointed out that, for those of ordinary skill in the art For, on the premise of conceiving without departing from technical scheme, it is also possible to make some deformation and improvement, these broadly fall into this The protection domain of application.

Claims (3)

1. the processing technology of a refined even stomatitis spray, it is characterised in that weigh by following part by weight: refined even 3-5 part, bamboo Leaf 1-2 part, Caulis Akebiae 1-2 part, Radix Rehmanniae 1.5-3 part, Radix Glycyrrhizae 0.5-1 part, Radix Scutellariae 1-2 part, Herba Menthae 1-2 part, with 5 times of weights after merging 75% soak with ethanol of amount more than 24 hours, is then heated to boiling 30-60 minute, filters, and filtering residue is again by the 75% of 3 times of weight Ethanol is heated to boiling and extracts 2-3 time, merging filtrate, and filtrate distillation is removed ethanol, adds boric acid, the addition of boric acid after cooling Amount is 3-4g/L.
The processing technology of a kind of refined even stomatitis spray the most according to claim 1, it is characterised in that by following weight ratio Example weighs: 4 parts of refined company, 1.5 parts of Folium Bambusae, Caulis Akebiae 1.5 parts, Radix Rehmanniae 2 parts, 0.8 part of Radix Glycyrrhizae, Radix Scutellariae 1.5 parts, Herba Menthae 1.5 parts.
The processing technology of a kind of refined even stomatitis spray the most according to claim 1, it is characterised in that with 5 times after merging 75% soak with ethanol of weight more than 24 hours, is then heated to seethe with excitement 45 minutes, filters, and filtering residue is again by the 75% of 3 times of weight Ethanol is heated to boiling and extracts 3 times, merging filtrate.
CN201610795045.1A 2016-08-31 2016-08-31 A kind of processing technology of refined even stomatitis spray Pending CN106215019A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258569A (en) * 2011-07-06 2011-11-30 张海 Chinese medicinal composition for treating stomatitis and sphagitis and preparation method thereof
CN103495048A (en) * 2013-09-09 2014-01-08 徐如阳 Traditional Chinese medicine composition for treating children's aphthous stomatitis
CN103816319A (en) * 2014-03-12 2014-05-28 齐鲁工业大学 Traditional Chinese medicine composition for treating stomatitis
CN104069376A (en) * 2014-06-21 2014-10-01 钟小强 Formula for treating ulcerative stomatitis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258569A (en) * 2011-07-06 2011-11-30 张海 Chinese medicinal composition for treating stomatitis and sphagitis and preparation method thereof
CN103495048A (en) * 2013-09-09 2014-01-08 徐如阳 Traditional Chinese medicine composition for treating children's aphthous stomatitis
CN103816319A (en) * 2014-03-12 2014-05-28 齐鲁工业大学 Traditional Chinese medicine composition for treating stomatitis
CN104069376A (en) * 2014-06-21 2014-10-01 钟小强 Formula for treating ulcerative stomatitis

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